ASS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.69322635
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.69322635
3L-phenylalanine metabolic process (GO:0006558)7.43630108
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.43630108
5aromatic amino acid family catabolic process (GO:0009074)6.99085269
6tryptophan catabolic process (GO:0006569)6.34264284
7indole-containing compound catabolic process (GO:0042436)6.34264284
8indolalkylamine catabolic process (GO:0046218)6.34264284
9epoxygenase P450 pathway (GO:0019373)6.32413638
10glyoxylate metabolic process (GO:0046487)6.16276124
11kynurenine metabolic process (GO:0070189)6.06555398
12tryptophan metabolic process (GO:0006568)5.96748795
13cysteine metabolic process (GO:0006534)5.88330561
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.77045400
15bile acid biosynthetic process (GO:0006699)5.77007977
16serine family amino acid catabolic process (GO:0009071)5.51892549
17sulfur amino acid catabolic process (GO:0000098)5.51706992
18homocysteine metabolic process (GO:0050667)5.36300807
19* urea metabolic process (GO:0019627)5.35736123
20* urea cycle (GO:0000050)5.35736123
21lysine metabolic process (GO:0006553)5.28150632
22lysine catabolic process (GO:0006554)5.28150632
23negative regulation of fibrinolysis (GO:0051918)5.27147630
24alpha-linolenic acid metabolic process (GO:0036109)5.26750874
25omega-hydroxylase P450 pathway (GO:0097267)5.16150061
26aromatic amino acid family metabolic process (GO:0009072)5.11784944
27high-density lipoprotein particle remodeling (GO:0034375)5.09673930
28protein carboxylation (GO:0018214)5.05496927
29peptidyl-glutamic acid carboxylation (GO:0017187)5.05496927
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.05024818
31regulation of fibrinolysis (GO:0051917)4.99798250
32complement activation, alternative pathway (GO:0006957)4.95906014
33regulation of protein activation cascade (GO:2000257)4.94594266
34amino-acid betaine metabolic process (GO:0006577)4.92642783
35* nitrogen cycle metabolic process (GO:0071941)4.90370061
36alpha-amino acid catabolic process (GO:1901606)4.85316805
37bile acid metabolic process (GO:0008206)4.85208776
38tyrosine metabolic process (GO:0006570)4.82644335
39NADH metabolic process (GO:0006734)4.76063481
40serine family amino acid metabolic process (GO:0009069)4.64112434
41glycine metabolic process (GO:0006544)4.63936378
42regulation of complement activation (GO:0030449)4.62146753
43ethanol metabolic process (GO:0006067)4.52570649
44drug catabolic process (GO:0042737)4.50666377
45cellular amino acid catabolic process (GO:0009063)4.49627362
46regulation of triglyceride catabolic process (GO:0010896)4.49263198
47regulation of cholesterol esterification (GO:0010872)4.48202973
48indolalkylamine metabolic process (GO:0006586)4.46897214
49serine family amino acid biosynthetic process (GO:0009070)4.46611505
50reverse cholesterol transport (GO:0043691)4.42243622
51glutamate metabolic process (GO:0006536)4.42023139
52plasma lipoprotein particle remodeling (GO:0034369)4.40490239
53protein-lipid complex remodeling (GO:0034368)4.40490239
54macromolecular complex remodeling (GO:0034367)4.40490239
55negative regulation of cholesterol transport (GO:0032375)4.39560410
56negative regulation of sterol transport (GO:0032372)4.39560410
57cellular modified amino acid catabolic process (GO:0042219)4.39414510
58amine catabolic process (GO:0009310)4.34769470
59cellular biogenic amine catabolic process (GO:0042402)4.34769470
60cellular ketone body metabolic process (GO:0046950)4.33674626
61aldehyde catabolic process (GO:0046185)4.33120643
62urate metabolic process (GO:0046415)4.29641121
63coenzyme catabolic process (GO:0009109)4.27329605
64triglyceride homeostasis (GO:0070328)4.26343703
65acylglycerol homeostasis (GO:0055090)4.26343703
66complement activation, classical pathway (GO:0006958)4.25630478
67imidazole-containing compound metabolic process (GO:0052803)4.25356332
68cellular glucuronidation (GO:0052695)4.20650512
69benzene-containing compound metabolic process (GO:0042537)4.19008500
70dicarboxylic acid biosynthetic process (GO:0043650)4.18924352
71plasma lipoprotein particle clearance (GO:0034381)4.16473285
72phospholipid efflux (GO:0033700)4.14071970
73drug transmembrane transport (GO:0006855)4.12419549
74exogenous drug catabolic process (GO:0042738)4.09667851
75bile acid and bile salt transport (GO:0015721)4.09639101
76ethanol oxidation (GO:0006069)4.04417181
77carboxylic acid catabolic process (GO:0046395)3.89235413
78organic acid catabolic process (GO:0016054)3.89235413
79acetyl-CoA metabolic process (GO:0006084)3.88614220
80short-chain fatty acid metabolic process (GO:0046459)3.85995649
81aspartate family amino acid catabolic process (GO:0009068)3.85105025
82complement activation (GO:0006956)3.83502716
83glucuronate metabolic process (GO:0019585)3.83285724
84uronic acid metabolic process (GO:0006063)3.83285724
85fibrinolysis (GO:0042730)3.82107895
86cholesterol efflux (GO:0033344)3.81096464
87cofactor catabolic process (GO:0051187)3.76968918
88oxaloacetate metabolic process (GO:0006107)3.75088363
892-oxoglutarate metabolic process (GO:0006103)3.74822898
90negative regulation of protein activation cascade (GO:2000258)3.73848822
91ketone body metabolic process (GO:1902224)3.73848434
92phenylpropanoid metabolic process (GO:0009698)3.71208488
93low-density lipoprotein particle remodeling (GO:0034374)3.70403798
94regulation of cholesterol homeostasis (GO:2000188)3.70392683
95* arginine metabolic process (GO:0006525)3.69772017
96proline metabolic process (GO:0006560)3.67395335
97NAD biosynthetic process (GO:0009435)3.66139591
98plasma lipoprotein particle assembly (GO:0034377)3.65733179
99primary alcohol catabolic process (GO:0034310)3.65172250
100pyridine nucleotide biosynthetic process (GO:0019363)3.64887167
101nicotinamide nucleotide biosynthetic process (GO:0019359)3.64887167
102protein activation cascade (GO:0072376)3.62617952
103phospholipid homeostasis (GO:0055091)3.62157074
104cholesterol homeostasis (GO:0042632)3.58621181
105regulation of bile acid biosynthetic process (GO:0070857)3.57822790
106carnitine metabolic process (GO:0009437)3.56607074
107intestinal absorption (GO:0050892)3.56596835
108sterol homeostasis (GO:0055092)3.54907566
109flavonoid metabolic process (GO:0009812)3.54638508
110desmosome organization (GO:0002934)3.54436787
111regulation of plasminogen activation (GO:0010755)3.53097801
112positive regulation of lipoprotein lipase activity (GO:0051006)3.51779787
113positive regulation of triglyceride lipase activity (GO:0061365)3.51779787
114blood coagulation, intrinsic pathway (GO:0007597)3.51128830
115drug metabolic process (GO:0017144)3.51076158
116drug transport (GO:0015893)3.50383432
117hormone catabolic process (GO:0042447)3.47808407
118negative regulation of complement activation (GO:0045916)3.47400636
119very-low-density lipoprotein particle assembly (GO:0034379)3.39094401
120* midgut development (GO:0007494)3.37414910
121negative regulation of lipase activity (GO:0060192)3.36984739
122citrulline biosynthetic process (GO:0019240)3.28707350
123proline biosynthetic process (GO:0006561)3.28188239
124polyketide metabolic process (GO:0030638)3.26002784
125doxorubicin metabolic process (GO:0044598)3.26002784
126daunorubicin metabolic process (GO:0044597)3.26002784
127Golgi transport vesicle coating (GO:0048200)3.24867826
128COPI coating of Golgi vesicle (GO:0048205)3.24867826
129L-serine metabolic process (GO:0006563)3.20967274
130positive regulation of lipid catabolic process (GO:0050996)3.19324739
131oxidative demethylation (GO:0070989)3.15605040
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11358358
133fat-soluble vitamin biosynthetic process (GO:0042362)3.10701372
134negative regulation of hemostasis (GO:1900047)3.09356450
135negative regulation of blood coagulation (GO:0030195)3.09356450
136regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.02560904
137triglyceride catabolic process (GO:0019433)3.01335799
138aminoglycoside antibiotic metabolic process (GO:0030647)3.00378398
139response to mercury ion (GO:0046689)3.00290337
140fructose metabolic process (GO:0006000)3.00067149
141primary alcohol metabolic process (GO:0034308)2.99861439
142folic acid metabolic process (GO:0046655)2.97917700
143regulation of cholesterol metabolic process (GO:0090181)2.95619612
144* glutamine family amino acid biosynthetic process (GO:0009084)2.93195341
145biotin metabolic process (GO:0006768)2.91716881
146negative regulation of fatty acid biosynthetic process (GO:0045717)2.91030810
147negative regulation of coagulation (GO:0050819)2.89971228
148acylglycerol catabolic process (GO:0046464)2.88415434

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25122959
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.12004268
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.69435340
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.28134891
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.11171909
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03546351
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90615863
8TP63_17297297_ChIP-ChIP_HaCaT_Human4.47481868
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05318393
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.82316668
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.70815908
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21932354
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17379614
14* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08997794
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7122617
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75370653
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74703828
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69951669
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.63717566
20CLOCK_20551151_ChIP-Seq_293T_Human1.62440071
21KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60029068
22E2F7_22180533_ChIP-Seq_HELA_Human1.59123310
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57872382
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57295461
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55547622
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49928615
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.46828982
28* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45045438
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.44831982
30* HNF4A_19822575_ChIP-Seq_HepG2_Human1.43032028
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.42994538
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39855520
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38054271
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36425993
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36314144
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.32582755
37ATF3_27146783_Chip-Seq_COLON_Human1.30760353
38SMC4_20622854_ChIP-Seq_HELA_Human1.26880575
39RUNX1_27514584_Chip-Seq_MCF-7_Human1.26756562
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26750491
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25984955
42GATA1_22025678_ChIP-Seq_K562_Human1.25319397
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25210865
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25161386
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22698500
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22617890
47HTT_18923047_ChIP-ChIP_STHdh_Human1.21456968
48SOX2_20726797_ChIP-Seq_SW620_Human1.21076408
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19968489
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19085573
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18739407
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18197051
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17765932
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16693299
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15468762
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14601167
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12216780
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.11859780
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10282197
60* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09732197
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09535308
62CREB1_26743006_Chip-Seq_LNCaP_Human1.09172523
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05040902
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.03929446
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01494674
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01419145
67* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00941106
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00742217
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98157608
70SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97186949
71P68_20966046_ChIP-Seq_HELA_Human0.96638074
72* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95903066
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95025275
74ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94557591
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94286741
76SA1_27219007_Chip-Seq_ERYTHROID_Human0.93196459
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93026452
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91213501
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91213501
80CTCF_27219007_Chip-Seq_Bcells_Human0.91074929
81* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90511074
82GATA4_25053715_ChIP-Seq_YYC3_Human0.90270525
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89555179
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87986124
85UBF1/2_26484160_Chip-Seq_HMECs_Human0.87556045
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87469187
87MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86734656
88ZNF263_19887448_ChIP-Seq_K562_Human0.86386354
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86211087
90* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83904215
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81150014
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79536877
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79274580
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.78893677
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78025772
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.74444212
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74046329
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71684087
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.69536757
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69466977
101* LXR_22292898_ChIP-Seq_THP-1_Human0.68994667
102RARB_24833708_ChIP-Seq_LIVER_Mouse0.68433754
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66885452
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66479670
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.63148425
106EGR1_19032775_ChIP-ChIP_M12_Human0.62240177
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60860244
108CEBPB_22108803_ChIP-Seq_LS180_Human0.59887917
109* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59718628
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59100657
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59049000
112GATA6_25053715_ChIP-Seq_YYC3_Human0.54654553
113AR_20517297_ChIP-Seq_VCAP_Human0.52404704
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.51712642
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.51357882
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.51357882
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50850107
118MYC_19915707_ChIP-ChIP_AK7_Human0.50765814
119RACK7_27058665_Chip-Seq_MCF-7_Human0.47392562
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47037381
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.46892585
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46862228
123SOX2_18692474_ChIP-Seq_MEFs_Mouse0.46315315
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46311819
125TAF2_19829295_ChIP-Seq_ESCs_Human0.46139563
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46033304
127AR_21909140_ChIP-Seq_LNCAP_Human0.45917709
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.45830735
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.45320528
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45058012
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44568281
132* ESET_19884257_ChIP-Seq_ESCs_Mouse0.43945497
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.43629987
134BCOR_27268052_Chip-Seq_Bcells_Human0.43201461
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.43025349
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.42637059
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42414147
138* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.41703873
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.41483449
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.41411887
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.41073973
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.40926059
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40878235
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.40283552
145P53_21459846_ChIP-Seq_SAOS-2_Human0.40243819
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.39230290
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.39013842
148STAT1_17558387_ChIP-Seq_HELA_Human0.38725583
149TCF3_18692474_ChIP-Seq_MEFs_Mouse0.38618567
150* TET1_21451524_ChIP-Seq_MESCs_Mouse0.38432163
151CBP_21632823_ChIP-Seq_H3396_Human0.38264155
152NANOG_16518401_ChIP-PET_MESCs_Mouse0.38238394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.91560732
2MP0005360_urolithiasis7.80643364
3MP0005085_abnormal_gallbladder_physiolo6.08689283
4MP0005365_abnormal_bile_salt5.85248134
5MP0008875_abnormal_xenobiotic_pharmacok4.94324338
6MP0003806_abnormal_nucleotide_metabolis4.38016372
7MP0003252_abnormal_bile_duct3.81141200
8MP0010234_abnormal_vibrissa_follicle3.31106265
9MP0010329_abnormal_lipoprotein_level3.29513382
10MP0009840_abnormal_foam_cell3.21546472
11* MP0005332_abnormal_amino_acid3.12437395
12MP0003195_calcinosis3.11355632
13MP0005083_abnormal_biliary_tract2.81101752
14MP0004019_abnormal_vitamin_homeostasis2.60921458
15MP0001666_abnormal_nutrient_absorption2.40351252
16MP0002138_abnormal_hepatobiliary_system2.33987221
17MP0008438_abnormal_cutaneous_collagen2.32194013
18MP0003191_abnormal_cellular_cholesterol2.27246569
19MP0000609_abnormal_liver_physiology2.10369775
20MP0002118_abnormal_lipid_homeostasis1.97854679
21MP0005319_abnormal_enzyme/_coenzyme1.91967196
22MP0001764_abnormal_homeostasis1.74859937
23MP0010352_gastrointestinal_tract_polyps1.68395884
24MP0003868_abnormal_feces_composition1.67251786
25MP0009643_abnormal_urine_homeostasis1.65653882
26MP0004858_abnormal_nervous_system1.60613311
27MP0004272_abnormal_basement_membrane1.57870326
28* MP0005584_abnormal_enzyme/coenzyme_acti1.57104981
29MP0004185_abnormal_adipocyte_glucose1.48737218
30MP0005501_abnormal_skin_physiology1.48150868
31MP0005451_abnormal_body_composition1.47932485
32* MP0003186_abnormal_redox_activity1.43632450
33MP0000579_abnormal_nail_morphology1.42879866
34MP0003941_abnormal_skin_development1.38418285
35MP0003705_abnormal_hypodermis_morpholog1.33740021
36MP0009697_abnormal_copulation1.28218117
37MP0009379_abnormal_foot_pigmentation1.26452183
38MP0010030_abnormal_orbit_morphology1.25348990
39MP0005375_adipose_tissue_phenotype1.25223381
40MP0005409_darkened_coat_color1.24793589
41MP0000598_abnormal_liver_morphology1.23229930
42MP0002060_abnormal_skin_morphology1.23144222
43MP0003011_delayed_dark_adaptation1.22066962
44MP0003566_abnormal_cell_adhesion1.21969376
45MP0000003_abnormal_adipose_tissue1.21949000
46MP0002098_abnormal_vibrissa_morphology1.19926924
47MP0005636_abnormal_mineral_homeostasis1.19569898
48MP0005076_abnormal_cell_differentiation1.18565646
49MP0009764_decreased_sensitivity_to1.17629585
50MP0000467_abnormal_esophagus_morphology1.12948167
51MP0000537_abnormal_urethra_morphology1.12494782
52MP0003656_abnormal_erythrocyte_physiolo1.12041687
53MP0001849_ear_inflammation1.11688261
54MP0005275_abnormal_skin_tensile1.08228068
55MP0000604_amyloidosis1.03108748
56MP0009763_increased_sensitivity_to1.02077115
57MP0000566_synostosis1.01895186
58MP0008469_abnormal_protein_level1.00421252
59MP0003879_abnormal_hair_cell0.97727339
60MP0002249_abnormal_larynx_morphology0.96930716
61MP0005647_abnormal_sex_gland0.96125562
62MP0001756_abnormal_urination0.95237475
63MP0004233_abnormal_muscle_weight0.94852610
64MP0005257_abnormal_intraocular_pressure0.94802251
65MP0000462_abnormal_digestive_system0.92293335
66MP0005670_abnormal_white_adipose0.91832265
67MP0002254_reproductive_system_inflammat0.91292886
68MP0006036_abnormal_mitochondrial_physio0.90765874
69MP0000477_abnormal_intestine_morphology0.90734654
70MP0000490_abnormal_crypts_of0.89224092
71* MP0009642_abnormal_blood_homeostasis0.88721555
72MP0005408_hypopigmentation0.88384480
73MP0000678_abnormal_parathyroid_gland0.88190636
74MP0000762_abnormal_tongue_morphology0.83867112
75MP0002136_abnormal_kidney_physiology0.83488237
76MP0005376_homeostasis/metabolism_phenot0.82744572
77MP0005084_abnormal_gallbladder_morpholo0.82733360
78MP0005503_abnormal_tendon_morphology0.80710186
79MP0009780_abnormal_chondrocyte_physiolo0.80639519
80MP0002896_abnormal_bone_mineralization0.79096846
81MP0000013_abnormal_adipose_tissue0.78959278
82MP0009765_abnormal_xenobiotic_induced0.77688617
83MP0006138_congestive_heart_failure0.77490156
84MP0003183_abnormal_peptide_metabolism0.77079245
85MP0004043_abnormal_pH_regulation0.75600557
86MP0002876_abnormal_thyroid_physiology0.75127888
87MP0002078_abnormal_glucose_homeostasis0.71663181
88MP0002877_abnormal_melanocyte_morpholog0.70597567
89MP0005266_abnormal_metabolism0.69157437
90MP0005220_abnormal_exocrine_pancreas0.69042784
91MP0001664_abnormal_digestion0.67766187
92MP0001661_extended_life_span0.67611631
93MP0005535_abnormal_body_temperature0.67550277
94MP0000538_abnormal_urinary_bladder0.66757226
95* MP0001216_abnormal_epidermal_layer0.66731873
96MP0003959_abnormal_lean_body0.66693612
97MP0010368_abnormal_lymphatic_system0.66610627
98MP0003693_abnormal_embryo_hatching0.65648717
99MP0005058_abnormal_lysosome_morphology0.65369746
100MP0003436_decreased_susceptibility_to0.65019196
101MP0005623_abnormal_meninges_morphology0.64799948
102MP0010771_integument_phenotype0.63874793
103MP0004957_abnormal_blastocyst_morpholog0.63618728
104MP0009053_abnormal_anal_canal0.63468557
105MP0000627_abnormal_mammary_gland0.62220225
106MP0002971_abnormal_brown_adipose0.62184440
107MP0005334_abnormal_fat_pad0.59933961
108MP0005197_abnormal_uvea_morphology0.59792983
109MP0005395_other_phenotype0.59773657
110MP0006035_abnormal_mitochondrial_morpho0.59632315
111MP0003329_amyloid_beta_deposits0.59459755
112MP0005464_abnormal_platelet_physiology0.56440800
113MP0004130_abnormal_muscle_cell0.55128790
114MP0003690_abnormal_glial_cell0.54462653
115MP0003724_increased_susceptibility_to0.53976091
116MP0003718_maternal_effect0.53012759
117MP0001765_abnormal_ion_homeostasis0.51967052
118MP0003638_abnormal_response/metabolism_0.51702825
119MP0002928_abnormal_bile_duct0.50714072
120MP0008873_increased_physiological_sensi0.49149337
121MP0002168_other_aberrant_phenotype0.48553985
122MP0006082_CNS_inflammation0.48275186
123MP0003075_altered_response_to0.47978780
124MP0001853_heart_inflammation0.47619529
125MP0001845_abnormal_inflammatory_respons0.43980831
126MP0005166_decreased_susceptibility_to0.43697067
127MP0000639_abnormal_adrenal_gland0.43576778
128MP0005448_abnormal_energy_balance0.42892129
129MP0005666_abnormal_adipose_tissue0.42015403
130MP0004782_abnormal_surfactant_physiolog0.41915464
131MP0008874_decreased_physiological_sensi0.40961888
132MP0002796_impaired_skin_barrier0.39102386
133MP0002135_abnormal_kidney_morphology0.37648342
134MP0003953_abnormal_hormone_level0.36697514
135MP0009672_abnormal_birth_weight0.36305455
136MP0008872_abnormal_physiological_respon0.35754487
137MP0000230_abnormal_systemic_arterial0.34446447
138MP0001243_abnormal_dermal_layer0.33157393
139MP0009115_abnormal_fat_cell0.32716210
140MP0000249_abnormal_blood_vessel0.32557607
141MP0005023_abnormal_wound_healing0.31422949
142MP0002970_abnormal_white_adipose0.30749295
143MP0004264_abnormal_extraembryonic_tissu0.29965724
144MP0009785_altered_susceptibility_to0.29532722
145MP0004883_abnormal_blood_vessel0.29123012
146MP0001881_abnormal_mammary_gland0.28959521
147MP0003453_abnormal_keratinocyte_physiol0.26789184
148MP0005164_abnormal_response_to0.26636341
149MP0004947_skin_inflammation0.26375982

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33853809
2Intrahepatic cholestasis (HP:0001406)6.84832542
3Deep venous thrombosis (HP:0002625)6.69939840
4* Abnormality of monocarboxylic acid metabolism (HP:0010996)6.29909635
5Xanthomatosis (HP:0000991)6.10207581
6Hypobetalipoproteinemia (HP:0003563)5.85912685
7Prolonged partial thromboplastin time (HP:0003645)5.83494707
8Hyperlipoproteinemia (HP:0010980)5.10340829
9Complement deficiency (HP:0004431)4.75615476
10* Hyperammonemia (HP:0001987)4.57539935
11Abnormality of sulfur amino acid metabolism (HP:0004339)4.52273947
12Hyperglycinemia (HP:0002154)4.51228614
13Abnormality of aspartate family amino acid metabolism (HP:0010899)4.49325582
14Hyperglycinuria (HP:0003108)4.48819956
15Joint hemorrhage (HP:0005261)4.48187723
16* Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40531044
17Hypolipoproteinemia (HP:0010981)4.39984101
18Ketosis (HP:0001946)4.36517944
19Abnormality of methionine metabolism (HP:0010901)4.30897015
20Abnormality of serine family amino acid metabolism (HP:0010894)4.28502360
21Abnormality of glycine metabolism (HP:0010895)4.28502360
22Epidermoid cyst (HP:0200040)4.19563597
23Abnormality of the common coagulation pathway (HP:0010990)4.05647567
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00998741
25Hypoalphalipoproteinemia (HP:0003233)3.85840133
26Fat malabsorption (HP:0002630)3.85174845
27Hypoglycemic coma (HP:0001325)3.73866571
28Abnormality of fatty-acid metabolism (HP:0004359)3.55396928
29Abnormality of complement system (HP:0005339)3.52167023
30Gout (HP:0001997)3.43469556
31* Abnormality of pyrimidine metabolism (HP:0004353)3.41711701
32Abnormality of the intrinsic pathway (HP:0010989)3.36382805
33Conjugated hyperbilirubinemia (HP:0002908)3.32515468
34Hypercholesterolemia (HP:0003124)3.30528300
35* Abnormality of nucleobase metabolism (HP:0010932)3.29069508
36Delayed CNS myelination (HP:0002188)3.25628856
37Abnormality of purine metabolism (HP:0004352)3.23323057
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21898416
39Protrusio acetabuli (HP:0003179)3.21489419
40Ketoacidosis (HP:0001993)3.20953549
41Hyperbilirubinemia (HP:0002904)3.16606302
42Premature rupture of membranes (HP:0001788)3.14352742
43Hepatocellular carcinoma (HP:0001402)3.00099966
44Metabolic acidosis (HP:0001942)2.90178563
45Steatorrhea (HP:0002570)2.89486125
46* Abnormality of serum amino acid levels (HP:0003112)2.89347548
47Myocardial infarction (HP:0001658)2.86348562
48Vascular calcification (HP:0004934)2.85746042
49Spastic diplegia (HP:0001264)2.77171720
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76803314
51Dicarboxylic aciduria (HP:0003215)2.76803314
52Systemic lupus erythematosus (HP:0002725)2.71879698
53* Lethargy (HP:0001254)2.70606993
54Spontaneous abortion (HP:0005268)2.68000288
55Nephritis (HP:0000123)2.67462190
56Generalized aminoaciduria (HP:0002909)2.63515322
57Proximal tubulopathy (HP:0000114)2.61812083
58Skin nodule (HP:0200036)2.61191601
59Vertebral compression fractures (HP:0002953)2.59294150
60Abnormality of the Achilles tendon (HP:0005109)2.58982199
61Cardiovascular calcification (HP:0011915)2.55175793
62Hypochromic microcytic anemia (HP:0004840)2.49929214
63Asymmetry of the thorax (HP:0001555)2.49234955
64Back pain (HP:0003418)2.45798872
65Malnutrition (HP:0004395)2.44662476
66* Irritability (HP:0000737)2.40727707
67Right ventricular cardiomyopathy (HP:0011663)2.40021743
68Recurrent gram-negative bacterial infections (HP:0005420)2.38035818
69Hyperuricemia (HP:0002149)2.36974273
70Increased purine levels (HP:0004368)2.36974273
71Abnormality of proline metabolism (HP:0010907)2.36048212
72Hydroxyprolinuria (HP:0003080)2.36048212
73Mitral stenosis (HP:0001718)2.33748596
74Abnormality of glycolysis (HP:0004366)2.28794559
75Glomerulonephritis (HP:0000099)2.26098582
76Esophageal varix (HP:0002040)2.24961112
77Abdominal distention (HP:0003270)2.24043556
78Hypoglycemic seizures (HP:0002173)2.22684085
79Pancreatitis (HP:0001733)2.22614623
80Rickets (HP:0002748)2.21546741
81* Vomiting (HP:0002013)2.20936686
82Sensorimotor neuropathy (HP:0007141)2.20297213
83Abnormal gallbladder morphology (HP:0012437)2.17403922
84Enlarged kidneys (HP:0000105)2.16374500
85Acanthocytosis (HP:0001927)2.16261654
86Abnormal enzyme/coenzyme activity (HP:0012379)2.15977843
87Pterygium (HP:0001059)2.15750331
88* Cerebral edema (HP:0002181)2.14940130
89Abnormal hair laboratory examination (HP:0003328)2.14560626
90Thin bony cortex (HP:0002753)2.14272874
91Cholelithiasis (HP:0001081)2.13872106
92Late onset (HP:0003584)2.13562600
93* Alkalosis (HP:0001948)2.13176232
94Increased serum pyruvate (HP:0003542)2.12242267
95Glycosuria (HP:0003076)2.11177787
96Abnormality of urine glucose concentration (HP:0011016)2.11177787
97Pili torti (HP:0003777)2.10797470
98* Neonatal onset (HP:0003623)2.10647202
99Abnormality of carpal bone ossification (HP:0006257)2.08967026
100Cholecystitis (HP:0001082)2.08926892
101Abnormal gallbladder physiology (HP:0012438)2.08926892
102Amyloidosis (HP:0011034)2.08650802
103Achilles tendon contracture (HP:0001771)2.08590145
104Thrombophlebitis (HP:0004418)2.08584921
105Opisthotonus (HP:0002179)2.05990498
106Abnormal cartilage morphology (HP:0002763)2.04486458
107Gingival bleeding (HP:0000225)2.03115011
108Reduced antithrombin III activity (HP:0001976)2.00419780
109Flat acetabular roof (HP:0003180)1.99022071
110Nausea (HP:0002018)1.98327640
111Menorrhagia (HP:0000132)1.98023772
112Abnormal delivery (HP:0001787)1.96361590
113Hyperactive renin-angiotensin system (HP:0000841)1.96241335
114Abnormality of transition element cation homeostasis (HP:0011030)1.94521076
115Brushfield spots (HP:0001088)1.93927440
116Abnormality of iron homeostasis (HP:0011031)1.92283010
117Hemorrhage of the eye (HP:0011885)1.91884871
118Abnormality of alkaline phosphatase activity (HP:0004379)1.91836052
119Fragile skin (HP:0001030)1.90762532
120Focal segmental glomerulosclerosis (HP:0000097)1.89618402
121Hypophosphatemic rickets (HP:0004912)1.86836684
122Elevated alkaline phosphatase (HP:0003155)1.86458771
123Ulnar bowing (HP:0003031)1.86224738
124Mildly elevated creatine phosphokinase (HP:0008180)1.84749011
125Abnormal tarsal ossification (HP:0008369)1.83461080
126Abnormality of the gallbladder (HP:0005264)1.81934026
127Atrophic scars (HP:0001075)1.81282434
128Blue sclerae (HP:0000592)1.80436910
129Renal tubular acidosis (HP:0001947)1.79749442
130Popliteal pterygium (HP:0009756)1.78666094
131Abnormality of vitamin metabolism (HP:0100508)1.75811528
132Hypophosphatemia (HP:0002148)1.75649324
133Glomerulosclerosis (HP:0000096)1.74816902
134Acanthosis nigricans (HP:0000956)1.73543173
135Nephrolithiasis (HP:0000787)1.73187380
136Ileus (HP:0002595)1.71944580
137Wide cranial sutures (HP:0010537)1.71766933
138Abnormality of the gastric mucosa (HP:0004295)1.71619584
139Abnormality of the distal phalanges of the toes (HP:0010182)1.70806300
140Ankle contracture (HP:0006466)1.69216674
141Biconcave vertebral bodies (HP:0004586)1.68933282
142Hyperparathyroidism (HP:0000843)1.68925734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.19392815
2FGFR44.50840524
3ERN14.34218186
4SIK13.84793249
5ERBB42.75567320
6SMG12.51612528
7EEF2K2.50566192
8TAOK32.33686510
9ICK2.16690623
10PKN22.15346981
11MST1R2.11298245
12INSRR2.06038555
13FLT31.94792226
14TYK21.91896661
15MAPK111.83789789
16TRIB31.83573081
17ABL21.79252981
18MAP2K41.70411071
19WNK41.64528958
20RPS6KB21.63718642
21PAK41.61729682
22PRPF4B1.61134380
23MUSK1.60051218
24WNK31.57936969
25TBK11.49747172
26STK38L1.49297792
27MAP2K21.48953217
28PIK3CG1.48234079
29NEK91.47420951
30SCYL21.46874305
31PDGFRA1.42780462
32LATS11.35147810
33PTK61.34733000
34MAP3K141.31479238
35TESK11.31284932
36GRK61.30555400
37KDR1.30467238
38NEK11.30413516
39LMTK21.27773048
40MAPKAPK31.24904614
41MAP2K31.21537967
42EPHB21.15077086
43MAP3K111.14100209
44JAK21.14031193
45MYLK1.11741124
46TTK1.11539746
47MAP3K31.09336892
48PRKG21.07907930
49NTRK11.05108710
50PINK11.03611535
51IRAK31.03411280
52PIK3CA1.01988633
53OXSR11.00841269
54EPHA21.00784563
55JAK11.00380124
56CDK120.99999750
57MAP3K20.96333127
58PBK0.95149294
59NEK60.94833615
60PIM20.93976195
61EPHB10.92740617
62MET0.92471947
63DAPK20.91019134
64MAP3K70.90806473
65MAP3K100.89514923
66NME10.87118439
67ERBB20.86561982
68FRK0.86150013
69MAP3K120.85347575
70DDR20.84264906
71PRKAA20.83896730
72CDK60.83498619
73MAPK40.80080183
74CDK70.79394914
75ARAF0.79329951
76PDK40.77766309
77PDK30.77766309
78CSK0.77540930
79DYRK1B0.77433653
80PRKCZ0.76358209
81ILK0.75565716
82GSK3A0.75366800
83PTK20.72223026
84IKBKE0.69807929
85TAOK20.68625182
86STK390.67719632
87KSR20.66015753
88PRKACG0.65039769
89SGK30.62775714
90FGFR20.61960440
91MAP3K50.61683937
92NME20.61180604
93FER0.60498426
94ACVR1B0.59813858
95EPHA30.58661571
96MAP3K10.57809366
97CDK40.56562855
98CSF1R0.56392590
99MAPK120.54440871
100MAP3K80.54208035
101AKT20.53748797
102BLK0.53337084
103MAP2K60.53103796
104PRKAA10.52940467
105AURKB0.52848093
106TGFBR20.52719965
107MAP4K10.51052134
108BRAF0.50620435
109RIPK10.49854307
110MAP3K60.49265825
111BMX0.48334509
112CAMK2G0.47998455
113BRSK10.46304541
114PDPK10.46260984
115FGFR30.45400353
116MAP3K130.44553064
117LRRK20.44370124
118PAK20.42620124
119ZAP700.41673051
120PDK20.41469021
121IKBKB0.40450589
122MTOR0.40319598
123STK160.39669940
124PRKCI0.39589547
125SGK4940.38305756
126SGK2230.38305756
127EIF2AK10.37599302
128EGFR0.37545421
129MAP2K10.36747244
130RET0.36716416
131TIE10.36253224
132SGK20.36133711
133IGF1R0.35825802
134JAK30.35338577
135MELK0.34366966
136PRKCQ0.33697891
137AURKA0.33178395
138CHUK0.33101509
139RPS6KA20.33040588
140TTN0.31531104
141MAPK70.31511999
142TESK20.31498317
143KIT0.30836853
144PIM10.30598689
145CAMK2D0.30245526
146MAPK150.29979133
147CSNK1G10.27818935
148MAPKAPK50.27259690
149LATS20.27054064
150STK380.26825196
151CDK80.26692741
152CDC42BPA0.26353026
153DAPK30.26261580
154PDK10.25779919
155MAP3K90.25251022
156SRPK10.25035287
157CAMK2B0.24646683
158STK240.21984019
159RPS6KB10.20963109

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26313757
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.64148383
3Nitrogen metabolism_Homo sapiens_hsa009103.60872415
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45396841
5* Arginine biosynthesis_Homo sapiens_hsa002202.94907636
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75769057
7Tryptophan metabolism_Homo sapiens_hsa003802.69731375
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67816219
9Complement and coagulation cascades_Homo sapiens_hsa046102.51343707
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47932580
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46824814
12Fatty acid degradation_Homo sapiens_hsa000712.46228390
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.43176792
14Butanoate metabolism_Homo sapiens_hsa006502.21809830
15Peroxisome_Homo sapiens_hsa041462.14629074
16Propanoate metabolism_Homo sapiens_hsa006402.00970972
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00357843
18Histidine metabolism_Homo sapiens_hsa003401.87139611
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82348255
20Chemical carcinogenesis_Homo sapiens_hsa052041.82065498
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80260444
22PPAR signaling pathway_Homo sapiens_hsa033201.77779224
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.77309522
24beta-Alanine metabolism_Homo sapiens_hsa004101.76832158
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75398488
26Fatty acid metabolism_Homo sapiens_hsa012121.73874098
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65767559
28Selenocompound metabolism_Homo sapiens_hsa004501.65610228
29* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65549075
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63307165
31Caffeine metabolism_Homo sapiens_hsa002321.62422688
32Staphylococcus aureus infection_Homo sapiens_hsa051501.62360903
33Phenylalanine metabolism_Homo sapiens_hsa003601.60922368
34Retinol metabolism_Homo sapiens_hsa008301.54846549
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.47517690
36Pyruvate metabolism_Homo sapiens_hsa006201.46332529
37Bile secretion_Homo sapiens_hsa049761.44164770
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40077939
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.35495618
40Tyrosine metabolism_Homo sapiens_hsa003501.34568161
41Sulfur metabolism_Homo sapiens_hsa009201.30837631
42* Biosynthesis of amino acids_Homo sapiens_hsa012301.30605542
43Folate biosynthesis_Homo sapiens_hsa007901.30432562
44Carbon metabolism_Homo sapiens_hsa012001.29338271
45Starch and sucrose metabolism_Homo sapiens_hsa005001.26378505
46Fatty acid elongation_Homo sapiens_hsa000621.13423063
47Steroid biosynthesis_Homo sapiens_hsa001001.11155722
48Arginine and proline metabolism_Homo sapiens_hsa003301.09377753
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09188082
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05406671
51ABC transporters_Homo sapiens_hsa020101.03208325
52Vitamin digestion and absorption_Homo sapiens_hsa049770.98604037
53Fat digestion and absorption_Homo sapiens_hsa049750.98001833
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94298891
55One carbon pool by folate_Homo sapiens_hsa006700.93675263
56Sulfur relay system_Homo sapiens_hsa041220.93604773
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87704106
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.83741489
59Lysine degradation_Homo sapiens_hsa003100.83233812
60Glutathione metabolism_Homo sapiens_hsa004800.82109306
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81396989
62Vitamin B6 metabolism_Homo sapiens_hsa007500.78602495
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74122457
64Pentose phosphate pathway_Homo sapiens_hsa000300.72613146
65Glycerolipid metabolism_Homo sapiens_hsa005610.66819150
66Protein digestion and absorption_Homo sapiens_hsa049740.58293134
67* Metabolic pathways_Homo sapiens_hsa011000.47873461
68Fructose and mannose metabolism_Homo sapiens_hsa000510.41116030
69Fatty acid biosynthesis_Homo sapiens_hsa000610.36859667
70Thyroid cancer_Homo sapiens_hsa052160.35193501
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31603832
72Galactose metabolism_Homo sapiens_hsa000520.30706351
73N-Glycan biosynthesis_Homo sapiens_hsa005100.30375826
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29855315
75Prion diseases_Homo sapiens_hsa050200.27082607
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26312476
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21114531
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19332213
79Insulin resistance_Homo sapiens_hsa049310.19079750
80ECM-receptor interaction_Homo sapiens_hsa045120.17322384
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16662466
82Amoebiasis_Homo sapiens_hsa051460.15658612
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14453629
84Linoleic acid metabolism_Homo sapiens_hsa005910.09452650
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09063036
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08112116
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.06964132
88Tight junction_Homo sapiens_hsa045300.05297179
89Small cell lung cancer_Homo sapiens_hsa052220.03913370
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02896313
91Glucagon signaling pathway_Homo sapiens_hsa049220.01348892
92Ribosome_Homo sapiens_hsa030100.01228471
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2028330
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2013534
95Bladder cancer_Homo sapiens_hsa05219-0.1982126
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1867045
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1863865
98Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1853801
99Legionellosis_Homo sapiens_hsa05134-0.1833129
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1794807
101African trypanosomiasis_Homo sapiens_hsa05143-0.1759627
102Mineral absorption_Homo sapiens_hsa04978-0.1732217
103Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1653862
104Other glycan degradation_Homo sapiens_hsa00511-0.1601084
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1530347
106Hepatitis C_Homo sapiens_hsa05160-0.1450801
107Lysosome_Homo sapiens_hsa04142-0.1292950
108Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1268651
109Regulation of autophagy_Homo sapiens_hsa04140-0.0988529
110Renin-angiotensin system_Homo sapiens_hsa04614-0.0644411
111Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0598595
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0594012
113AMPK signaling pathway_Homo sapiens_hsa04152-0.0157729
114Sphingolipid metabolism_Homo sapiens_hsa00600-0.0068074

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