ASS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.18626725
2neutrophil activation involved in immune response (GO:0002283)5.66487276
3regulation of platelet aggregation (GO:0090330)5.15911244
4regulation of platelet activation (GO:0010543)5.01445137
5negative regulation of thymocyte apoptotic process (GO:0070244)5.01350959
6fusion of sperm to egg plasma membrane (GO:0007342)4.86989826
7protein neddylation (GO:0045116)4.54068190
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33246816
9positive regulation of granulocyte differentiation (GO:0030854)4.15826126
10positive regulation of B cell differentiation (GO:0045579)4.14980162
11purinergic nucleotide receptor signaling pathway (GO:0035590)4.12192541
12spermatid nucleus differentiation (GO:0007289)3.94991216
13megakaryocyte development (GO:0035855)3.86000920
14positive regulation of endothelial cell differentiation (GO:0045603)3.82895204
15positive regulation of mast cell activation (GO:0033005)3.77938420
16regulation of integrin activation (GO:0033623)3.75201680
17positive regulation of systemic arterial blood pressure (GO:0003084)3.73784414
18negative regulation of T cell apoptotic process (GO:0070233)3.70290168
19platelet aggregation (GO:0070527)3.69169587
20negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.68776047
21blood coagulation, intrinsic pathway (GO:0007597)3.61074482
22plasma membrane fusion (GO:0045026)3.59592220
23neutrophil activation (GO:0042119)3.57751155
24adenosine receptor signaling pathway (GO:0001973)3.57271541
25lipoxygenase pathway (GO:0019372)3.54605773
26microtubule depolymerization (GO:0007019)3.54178572
27sperm motility (GO:0030317)3.53807599
28regulation of female receptivity (GO:0045924)3.52247331
29negative regulation of heart rate (GO:0010459)3.48132073
30G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.45870469
31multicellular organism reproduction (GO:0032504)3.41969732
32purinergic receptor signaling pathway (GO:0035587)3.41774129
33positive regulation of gamma-delta T cell activation (GO:0046645)3.37919055
34mast cell activation (GO:0045576)3.30329135
35negative regulation of homotypic cell-cell adhesion (GO:0034111)3.28690192
36female mating behavior (GO:0060180)3.27993577
37regulation of Golgi to plasma membrane protein transport (GO:0042996)3.27690666
38B cell receptor signaling pathway (GO:0050853)3.25367429
39leukocyte migration involved in inflammatory response (GO:0002523)3.23665127
40single strand break repair (GO:0000012)3.23634850
41negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.23618490
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.22334759
43negative regulation of platelet activation (GO:0010544)3.21526745
44B cell mediated immunity (GO:0019724)3.20073323
45negative T cell selection (GO:0043383)3.18701800
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16887327
47negative regulation of T-helper cell differentiation (GO:0045623)3.16887327
48negative thymic T cell selection (GO:0045060)3.16141301
49mitochondrial calcium ion transport (GO:0006851)3.14615639
50regulation of memory T cell differentiation (GO:0043380)3.13634991
51mast cell activation involved in immune response (GO:0002279)3.12026196
52mast cell degranulation (GO:0043303)3.12026196
53leukocyte degranulation (GO:0043299)3.10036209
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05499292
55angiogenesis involved in wound healing (GO:0060055)3.03806033
56autophagic vacuole fusion (GO:0000046)3.03491578
57regulation of gamma-delta T cell differentiation (GO:0045586)3.01564640
58granulocyte activation (GO:0036230)2.96638418
59negative regulation of response to food (GO:0032096)2.94556149
60negative regulation of appetite (GO:0032099)2.94556149
61regulation of mast cell activation (GO:0033003)2.92771355
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91004641
63negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90146483
64negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.89122056
65regulation of mast cell degranulation (GO:0043304)2.88856061
66monoamine transport (GO:0015844)2.88819379
67positive regulation of mast cell degranulation (GO:0043306)2.88487698
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.88487698
69regulation of B cell receptor signaling pathway (GO:0050855)2.88358953
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88073235
71definitive hemopoiesis (GO:0060216)2.88051742
72cardiolipin metabolic process (GO:0032048)2.87344979
73regulation of thymocyte apoptotic process (GO:0070243)2.86933723
74low-density lipoprotein particle remodeling (GO:0034374)2.86855062
75positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.85830246
76regulation of B cell differentiation (GO:0045577)2.85555890
77cellular response to exogenous dsRNA (GO:0071360)2.83380896
78positive regulation of isotype switching (GO:0045830)2.83157962
79negative regulation of interleukin-17 production (GO:0032700)2.82382707
80positive thymic T cell selection (GO:0045059)2.80216357
81regulation of granulocyte differentiation (GO:0030852)2.79262255
82positive regulation of macrophage differentiation (GO:0045651)2.78819878
83regulation of homotypic cell-cell adhesion (GO:0034110)2.78639514
84pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77045248
85negative regulation of stress fiber assembly (GO:0051497)2.76983621
86positive regulation of DNA recombination (GO:0045911)2.74952808
87myeloid cell activation involved in immune response (GO:0002275)2.73110831
88regulation of mast cell activation involved in immune response (GO:0033006)2.72873624
89regulation of alpha-beta T cell proliferation (GO:0046640)2.72852012
90regulation of MHC class II biosynthetic process (GO:0045346)2.72580745
91organelle membrane fusion (GO:0090174)2.71858969
92immunoglobulin mediated immune response (GO:0016064)2.71050531
93regulation of endothelial cell differentiation (GO:0045601)2.70912597
94positive regulation of cAMP-mediated signaling (GO:0043950)2.69822693
95aggressive behavior (GO:0002118)2.68942412
96negative regulation of norepinephrine secretion (GO:0010700)2.66082853
97regulation of macrophage derived foam cell differentiation (GO:0010743)2.66082629
98hepatocyte apoptotic process (GO:0097284)2.65603557
99relaxation of smooth muscle (GO:0044557)2.65399694
100regulation of germinal center formation (GO:0002634)2.65293092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.14004865
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.80831038
3SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.74046805
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.70117396
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.35703176
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18976102
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.08616908
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05511225
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.98600350
10GATA1_22025678_ChIP-Seq_K562_Human2.84580231
11RUNX_20019798_ChIP-Seq_JUKART_Human2.72595062
12GATA1_19941826_ChIP-Seq_K562_Human2.70307122
13LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.64101659
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62787888
15GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.59674974
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43502307
17SPI1_23127762_ChIP-Seq_K562_Human2.22831633
18GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.19364214
19MYB_26560356_Chip-Seq_TH2_Human2.18406656
20GATA2_19941826_ChIP-Seq_K562_Human2.01820183
21GATA1_19941827_ChIP-Seq_MEL_Mouse2.01334400
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94728745
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83350446
24GATA3_27048872_Chip-Seq_THYMUS_Human1.83189310
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.82016439
26GATA3_26560356_Chip-Seq_TH2_Human1.81588047
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78411224
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.75410790
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75198386
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70933323
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65578840
32MYB_26560356_Chip-Seq_TH1_Human1.64997000
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.64608582
34UTX_26944678_Chip-Seq_JUKART_Human1.64107056
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64048391
36GATA1_22383799_ChIP-Seq_G1ME_Mouse1.59398061
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58228417
38SPI1_23547873_ChIP-Seq_NB4_Human1.57225311
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55540300
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53371588
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51219470
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50131157
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49805696
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.47949384
45EZH2_22144423_ChIP-Seq_EOC_Human1.47233179
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44492635
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43251576
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42563431
49SPI1_20517297_ChIP-Seq_HL60_Human1.38532532
50NANOG_20526341_ChIP-Seq_ESCs_Human1.37230199
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34475728
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32491954
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32169392
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32131011
55GATA1_19941827_ChIP-Seq_MEL86_Mouse1.26251785
56VDR_24763502_ChIP-Seq_THP-1_Human1.25364944
57BCL6_27268052_Chip-Seq_Bcells_Human1.25161322
58MAF_26560356_Chip-Seq_TH1_Human1.24061908
59P300_27268052_Chip-Seq_Bcells_Human1.20931357
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20414338
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.20164990
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16992231
63SMRT_27268052_Chip-Seq_Bcells_Human1.16631998
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16278452
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15242793
66HTT_18923047_ChIP-ChIP_STHdh_Human1.14240242
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13243117
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13218080
69ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12332369
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10981699
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.10802100
72IRF1_19129219_ChIP-ChIP_H3396_Human1.09577372
73STAT1_20625510_ChIP-Seq_HELA_Human1.09349669
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07711967
75VDR_22108803_ChIP-Seq_LS180_Human1.06883298
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06860552
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05973940
78CEBPB_22108803_ChIP-Seq_LS180_Human1.05052124
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03936445
80GATA3_26560356_Chip-Seq_TH1_Human1.03706738
81SALL4_22934838_ChIP-ChIP_CD34+_Human1.03397327
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01143167
83ERG_20517297_ChIP-Seq_VCAP_Human1.01133418
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00185903
85VDR_24787735_ChIP-Seq_THP-1_Human1.00163111
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99361494
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96413551
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.96266229
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94772585
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94197750
91ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93947108
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93900857
93SOX2_19829295_ChIP-Seq_ESCs_Human0.93096584
94NANOG_19829295_ChIP-Seq_ESCs_Human0.93096584
95YY1_22570637_ChIP-Seq_MALME-3M_Human0.92911364
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90977374
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89535058
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87944134
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86440856
100BCOR_27268052_Chip-Seq_Bcells_Human0.86081505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.12858858
2MP0005410_abnormal_fertilization3.68728417
3MP0001835_abnormal_antigen_presentation3.49227338
4MP0003724_increased_susceptibility_to2.98857471
5MP0000465_gastrointestinal_hemorrhage2.96411857
6MP0008004_abnormal_stomach_pH2.93875287
7MP0001545_abnormal_hematopoietic_system2.66339911
8MP0005397_hematopoietic_system_phenotyp2.66339911
9MP0009278_abnormal_bone_marrow2.38013845
10MP0005671_abnormal_response_to2.31791467
11MP0003303_peritoneal_inflammation2.29325903
12MP0005000_abnormal_immune_tolerance2.19328498
13MP0003763_abnormal_thymus_physiology2.18802063
14MP0001800_abnormal_humoral_immune2.12139410
15MP0002148_abnormal_hypersensitivity_rea2.12013282
16MP0002398_abnormal_bone_marrow2.11011437
17MP0002723_abnormal_immune_serum1.98240073
18MP0003436_decreased_susceptibility_to1.89111470
19MP0009333_abnormal_splenocyte_physiolog1.78197369
20MP0002420_abnormal_adaptive_immunity1.77956549
21MP0002452_abnormal_antigen_presenting1.76504087
22MP0001819_abnormal_immune_cell1.75551047
23MP0000685_abnormal_immune_system1.72039969
24MP0010155_abnormal_intestine_physiology1.72034499
25MP0002132_abnormal_respiratory_system1.70169014
26MP0000689_abnormal_spleen_morphology1.68501847
27MP0008872_abnormal_physiological_respon1.67706692
28MP0003638_abnormal_response/metabolism_1.66234578
29MP0001968_abnormal_touch/_nociception1.66010604
30MP0009697_abnormal_copulation1.65644238
31MP0001851_eye_inflammation1.58674824
32MP0000716_abnormal_immune_system1.58530414
33MP0005025_abnormal_response_to1.55913435
34MP0002722_abnormal_immune_system1.53285092
35MP0002429_abnormal_blood_cell1.52126056
36MP0000230_abnormal_systemic_arterial1.52122692
37MP0002419_abnormal_innate_immunity1.46054561
38MP0001790_abnormal_immune_system1.36990675
39MP0005387_immune_system_phenotype1.36990675
40MP0005084_abnormal_gallbladder_morpholo1.35207655
41MP0000343_altered_response_to1.35156510
42MP0005083_abnormal_biliary_tract1.32664089
43MP0004947_skin_inflammation1.32660250
44MP0002736_abnormal_nociception_after1.32408139
45MP0009764_decreased_sensitivity_to1.30781567
46MP0000703_abnormal_thymus_morphology1.28974020
47MP0008775_abnormal_heart_ventricle1.27820730
48MP0003718_maternal_effect1.27696510
49MP0005167_abnormal_blood-brain_barrier1.26584253
50MP0004130_abnormal_muscle_cell1.26036373
51MP0002405_respiratory_system_inflammati1.25915471
52MP0001845_abnormal_inflammatory_respons1.18611186
53MP0003656_abnormal_erythrocyte_physiolo1.17056426
54MP0005645_abnormal_hypothalamus_physiol1.16302524
55MP0001533_abnormal_skeleton_physiology1.15668450
56MP0003698_abnormal_male_reproductive1.15512581
57MP0000015_abnormal_ear_pigmentation1.14942339
58MP0001663_abnormal_digestive_system1.14772010
59MP0002396_abnormal_hematopoietic_system1.11871620
60MP0001929_abnormal_gametogenesis1.11321123
61MP0000249_abnormal_blood_vessel1.08888043
62MP0004084_abnormal_cardiac_muscle1.08455487
63MP0009763_increased_sensitivity_to1.08116076
64MP0004036_abnormal_muscle_relaxation1.06461400
65MP0003866_abnormal_defecation1.04592572
66MP0005646_abnormal_pituitary_gland1.04138466
67MP0005670_abnormal_white_adipose1.03088418
68MP0002733_abnormal_thermal_nociception1.02813693
69MP0005310_abnormal_salivary_gland0.99140724
70MP0002138_abnormal_hepatobiliary_system0.96759206
71MP0009785_altered_susceptibility_to0.96463697
72MP0004808_abnormal_hematopoietic_stem0.92929770
73MP0005174_abnormal_tail_pigmentation0.92741033
74MP0009765_abnormal_xenobiotic_induced0.92481994
75MP0004510_myositis0.90437330
76MP0001879_abnormal_lymphatic_vessel0.87612313
77MP0001765_abnormal_ion_homeostasis0.87403384
78MP0004142_abnormal_muscle_tone0.87038176
79MP0003011_delayed_dark_adaptation0.86744162
80MP0002019_abnormal_tumor_incidence0.84813252
81MP0008877_abnormal_DNA_methylation0.84207389
82MP0004381_abnormal_hair_follicle0.82152000
83MP0003828_pulmonary_edema0.78907204
84MP0002876_abnormal_thyroid_physiology0.76579675
85MP0009642_abnormal_blood_homeostasis0.74644649
86MP0001986_abnormal_taste_sensitivity0.74364370
87MP0008057_abnormal_DNA_replication0.72051483
88MP0002998_abnormal_bone_remodeling0.70907855
89MP0002653_abnormal_ependyma_morphology0.69231538
90MP0008469_abnormal_protein_level0.68556234
91MP0005058_abnormal_lysosome_morphology0.68213943
92MP0010329_abnormal_lipoprotein_level0.67443143
93MP0008874_decreased_physiological_sensi0.65731723
94MP0008058_abnormal_DNA_repair0.65720013
95MP0006036_abnormal_mitochondrial_physio0.65624786
96MP0000858_altered_metastatic_potential0.65497490
97MP0001664_abnormal_digestion0.65383320
98MP0008995_early_reproductive_senescence0.63382400
99MP0004484_altered_response_of0.62330118
100MP0005666_abnormal_adipose_tissue0.61411619

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.15673189
2Petechiae (HP:0000967)7.35088729
3Menorrhagia (HP:0000132)7.24784877
4Increased mean platelet volume (HP:0011877)6.92152500
5Abnormal platelet volume (HP:0011876)6.65592388
6Purpura (HP:0000979)6.02462095
7Epistaxis (HP:0000421)5.92982982
8Gingival bleeding (HP:0000225)4.80366766
9Stomatitis (HP:0010280)4.40310391
10Panhypogammaglobulinemia (HP:0003139)4.38788745
11Hyperlipoproteinemia (HP:0010980)4.34867684
12Agammaglobulinemia (HP:0004432)3.86332368
13Dyschromatopsia (HP:0007641)3.80371920
14Impaired platelet aggregation (HP:0003540)3.59492244
15Abnormal platelet function (HP:0011869)3.59492244
16Elevated erythrocyte sedimentation rate (HP:0003565)3.52795216
17Metaphyseal dysplasia (HP:0100255)3.25708680
18Encephalitis (HP:0002383)3.24224030
19Spontaneous hematomas (HP:0007420)3.15848817
20Abnormality of lateral ventricle (HP:0030047)3.11256524
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.07853403
223-Methylglutaconic aciduria (HP:0003535)3.04632545
23Autoimmune hemolytic anemia (HP:0001890)2.98585038
24Abnormal pupillary function (HP:0007686)2.95497425
25Abnormality of the prostate (HP:0008775)2.94458405
26Poikilocytosis (HP:0004447)2.93791319
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.93713321
28Increased IgM level (HP:0003496)2.88850249
29Decreased central vision (HP:0007663)2.88586705
30Acanthocytosis (HP:0001927)2.73415185
31Inflammation of the large intestine (HP:0002037)2.72689497
32Abnormality of T cell physiology (HP:0011840)2.71968151
33Paralysis (HP:0003470)2.64670945
34Conjunctival telangiectasia (HP:0000524)2.64017492
35Recurrent viral infections (HP:0004429)2.62911532
36IgG deficiency (HP:0004315)2.59507873
37Abnormality of T cells (HP:0002843)2.56954711
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.55018189
39Absent/shortened dynein arms (HP:0200106)2.55018189
40Colitis (HP:0002583)2.51221360
41Gastrointestinal inflammation (HP:0004386)2.49660514
42Abnormal spermatogenesis (HP:0008669)2.43745600
43Granulocytopenia (HP:0001913)2.42261892
44Infertility (HP:0000789)2.40771392
45Recurrent fungal infections (HP:0002841)2.38619193
46Generalized aminoaciduria (HP:0002909)2.38119116
47Bruising susceptibility (HP:0000978)2.34625256
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31465412
49Joint swelling (HP:0001386)2.30936926
50Myositis (HP:0100614)2.30492822
51Severe visual impairment (HP:0001141)2.27743924
52Meningitis (HP:0001287)2.27151887
53Attenuation of retinal blood vessels (HP:0007843)2.24764413
54Abnormality of T cell number (HP:0011839)2.22879700
55Severe combined immunodeficiency (HP:0004430)2.18995537
56Abnormal ciliary motility (HP:0012262)2.18653048
57T lymphocytopenia (HP:0005403)2.15577397
58Chronic mucocutaneous candidiasis (HP:0002728)2.14705578
59Recurrent cutaneous fungal infections (HP:0011370)2.14705578
60Fatigue (HP:0012378)2.13196715
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12222917
62Hepatosplenomegaly (HP:0001433)2.10281045
63Prostate neoplasm (HP:0100787)2.03383963
64Obstructive lung disease (HP:0006536)2.02118487
65Chronic obstructive pulmonary disease (HP:0006510)2.02118487
66Abnormal respiratory epithelium morphology (HP:0012253)2.00289325
67Abnormal respiratory motile cilium morphology (HP:0005938)2.00289325
68Eosinophilia (HP:0001880)2.00132493
69Abnormality of macrophages (HP:0004311)1.98153514
70Recurrent abscess formation (HP:0002722)1.95711514
71Abnormality of B cell number (HP:0010975)1.95187422
72Leukocytosis (HP:0001974)1.95076247
73Arterial thrombosis (HP:0004420)1.93472016
74Chronic otitis media (HP:0000389)1.90306478
75B lymphocytopenia (HP:0010976)1.89915040
76Thrombocytosis (HP:0001894)1.87383092
77Spontaneous abortion (HP:0005268)1.82922438
78IgM deficiency (HP:0002850)1.82030729
79Abnormality of eosinophils (HP:0001879)1.81506659
80Episodic fever (HP:0001954)1.78290147
81Autoimmune thrombocytopenia (HP:0001973)1.78200273
82Acute hepatic failure (HP:0006554)1.77248410
83Abnormality of dental color (HP:0011073)1.75948066
84Acute lymphatic leukemia (HP:0006721)1.75231449
85Nasal polyposis (HP:0100582)1.75119625
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75098741
87Abnormality of the common coagulation pathway (HP:0010990)1.74653049
88Abnormality of iron homeostasis (HP:0011031)1.72914369
89Thyroiditis (HP:0100646)1.72651473
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71662937
91Abnormal rod and cone electroretinograms (HP:0008323)1.71290500
92Azoospermia (HP:0000027)1.71259431
93Thyroid-stimulating hormone excess (HP:0002925)1.68433872
94Abnormality of transition element cation homeostasis (HP:0011030)1.67784129
95Chest pain (HP:0100749)1.66770382
96Viral hepatitis (HP:0006562)1.66655200
97Biliary tract neoplasm (HP:0100574)1.66206183
98Amelogenesis imperfecta (HP:0000705)1.65698343
99Male infertility (HP:0003251)1.65177135
100Recurrent bacterial skin infections (HP:0005406)1.63948025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.12600352
2TEC3.85313326
3RIPK43.85031439
4BTK3.28126166
5MST43.13075577
6MAP4K13.02884997
7GRK62.59114832
8CSF1R2.46982121
9SYK2.37931804
10ITK2.19794877
11TESK22.15956934
12MAP4K22.10353684
13PIK3CG2.06157030
14TXK1.98487768
15BMX1.94079294
16FES1.87094311
17GRK51.81829711
18BMPR1B1.80026622
19ZAP701.72514441
20PTK2B1.70958020
21MAPKAPK31.65289545
22HCK1.65115654
23MYLK1.63100428
24CDK81.61303805
25IKBKB1.59209695
26PLK41.55978457
27INSRR1.39792972
28BMPR21.38740144
29BLK1.34401008
30FRK1.33671513
31NUAK11.29860002
32MAP3K111.22867689
33ZAK1.22029835
34LYN1.21298866
35TNK21.20968540
36ADRBK21.16816334
37KIT1.12075630
38IKBKE1.09731728
39PDK11.04924989
40LCK1.04165184
41EIF2AK11.03179006
42VRK10.97872120
43TBK10.96052507
44TLK10.92291902
45CAMKK20.87103918
46MATK0.85428934
47PLK20.81958836
48ILK0.79980050
49STK30.79910412
50JAK30.78850405
51PIM10.78626757
52CDK90.78259896
53JAK10.69581870
54TRIM280.65611163
55PIM20.65116657
56PDPK10.63045494
57FLT30.61669768
58PRKCQ0.60182676
59PAK10.58608074
60MAPK110.58130546
61MAP3K130.57976969
62RPS6KA50.56096504
63MARK30.55069867
64DAPK30.53921866
65KDR0.53724608
66DAPK10.52940876
67MAPK130.50357725
68ADRBK10.49712360
69TGFBR10.49072219
70JAK20.47770164
71IGF1R0.45825103
72ACVR1B0.45701616
73FGR0.45617060
74TRPM70.44663483
75VRK20.44456492
76PIK3CA0.43317752
77STK40.43283157
78MAP2K30.41583959
79PKN10.39024891
80MAP3K10.38817714
81PRKD10.38355255
82GRK10.37976665
83MAPK120.37738635
84MAP3K140.37308575
85STK380.37198400
86MAP3K50.36739868
87FYN0.36528757
88ABL10.36068931
89CSK0.33887491
90RET0.33313608
91PRKG10.31663961
92TESK10.30299092
93MAPKAPK20.30201747
94GRK70.27116614
95DAPK20.26466270
96STK160.25179309
97PRKCD0.22908071
98MAPK30.22882726
99PRKCA0.22801093
100CAMK10.20037342

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046114.38163667
2Primary immunodeficiency_Homo sapiens_hsa053403.61450503
3Allograft rejection_Homo sapiens_hsa053302.61372090
4Hematopoietic cell lineage_Homo sapiens_hsa046402.58233300
5Autoimmune thyroid disease_Homo sapiens_hsa053202.43759436
6Graft-versus-host disease_Homo sapiens_hsa053322.38446416
7Nitrogen metabolism_Homo sapiens_hsa009102.36720888
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.35192557
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.29522795
10B cell receptor signaling pathway_Homo sapiens_hsa046622.10477923
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.07416590
12Arachidonic acid metabolism_Homo sapiens_hsa005901.90619182
13Olfactory transduction_Homo sapiens_hsa047401.90569545
14Asthma_Homo sapiens_hsa053101.81383773
15Type I diabetes mellitus_Homo sapiens_hsa049401.73028992
16T cell receptor signaling pathway_Homo sapiens_hsa046601.54843290
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53571366
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44705891
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41783972
20Antigen processing and presentation_Homo sapiens_hsa046121.38933348
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36718231
22Chemokine signaling pathway_Homo sapiens_hsa040621.35856650
23Mismatch repair_Homo sapiens_hsa034301.32556085
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.31845937
25Systemic lupus erythematosus_Homo sapiens_hsa053221.30147951
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.28961938
27Linoleic acid metabolism_Homo sapiens_hsa005911.24607172
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16897877
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13448163
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.12987173
31Staphylococcus aureus infection_Homo sapiens_hsa051501.11612279
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11193976
33Homologous recombination_Homo sapiens_hsa034401.08313805
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07167088
35Viral myocarditis_Homo sapiens_hsa054161.05284297
36Osteoclast differentiation_Homo sapiens_hsa043801.00107661
37Serotonergic synapse_Homo sapiens_hsa047260.99938485
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99785620
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.99095474
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98919352
41Leishmaniasis_Homo sapiens_hsa051400.95790520
42Phototransduction_Homo sapiens_hsa047440.93164582
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87568567
44Herpes simplex infection_Homo sapiens_hsa051680.85985820
45Fatty acid elongation_Homo sapiens_hsa000620.83106453
46Glycerolipid metabolism_Homo sapiens_hsa005610.81834474
47Calcium signaling pathway_Homo sapiens_hsa040200.80458146
48Non-small cell lung cancer_Homo sapiens_hsa052230.80051766
49Ether lipid metabolism_Homo sapiens_hsa005650.79246020
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77172591
51Measles_Homo sapiens_hsa051620.76860092
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76596259
53Fanconi anemia pathway_Homo sapiens_hsa034600.76524105
54Viral carcinogenesis_Homo sapiens_hsa052030.76270792
55Base excision repair_Homo sapiens_hsa034100.75982183
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74752354
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74370490
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73403302
59Acute myeloid leukemia_Homo sapiens_hsa052210.73395290
60Alcoholism_Homo sapiens_hsa050340.73208906
61Endocytosis_Homo sapiens_hsa041440.72993733
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72968146
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70277296
64Pancreatic secretion_Homo sapiens_hsa049720.68768898
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68613207
66Rheumatoid arthritis_Homo sapiens_hsa053230.67244623
67Malaria_Homo sapiens_hsa051440.66767134
68Purine metabolism_Homo sapiens_hsa002300.66300672
69Gap junction_Homo sapiens_hsa045400.65041861
70ECM-receptor interaction_Homo sapiens_hsa045120.60848516
71Toxoplasmosis_Homo sapiens_hsa051450.60694598
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60023821
73Inositol phosphate metabolism_Homo sapiens_hsa005620.59744590
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59036780
75Shigellosis_Homo sapiens_hsa051310.58005021
76Long-term depression_Homo sapiens_hsa047300.57356312
77Butanoate metabolism_Homo sapiens_hsa006500.56864789
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.55821766
79Influenza A_Homo sapiens_hsa051640.55423005
80Glutathione metabolism_Homo sapiens_hsa004800.51568801
81Tuberculosis_Homo sapiens_hsa051520.51555168
82Renin secretion_Homo sapiens_hsa049240.51280694
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.51234697
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.49250638
85Collecting duct acid secretion_Homo sapiens_hsa049660.48880290
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.47862820
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46146197
88Apoptosis_Homo sapiens_hsa042100.46016315
89Phagosome_Homo sapiens_hsa041450.46008497
90Chemical carcinogenesis_Homo sapiens_hsa052040.45868570
91Choline metabolism in cancer_Homo sapiens_hsa052310.44807259
92Circadian entrainment_Homo sapiens_hsa047130.43898012
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42214234
94VEGF signaling pathway_Homo sapiens_hsa043700.41840254
95Dorso-ventral axis formation_Homo sapiens_hsa043200.41022064
96TNF signaling pathway_Homo sapiens_hsa046680.39188393
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38238205
98Taste transduction_Homo sapiens_hsa047420.38159737
99Peroxisome_Homo sapiens_hsa041460.38144891
100Fatty acid biosynthesis_Homo sapiens_hsa000610.37250283

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