ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	9.80909812
2	regulation of female gonad development (GO:2000194)	8.89755186
3	retinal cone cell development (GO:0046549)	8.49222359
4	piRNA metabolic process (GO:0034587)	7.78261360
5	meiotic cell cycle (GO:0051321)	7.73765596
6	regulation of acrosome reaction (GO:0060046)	7.67767581
7	regulation of meiosis I (GO:0060631)	7.15497556
8	positive regulation of histone H3-K4 methylation (GO:0051571)	6.85192121
9	multicellular organism reproduction (GO:0032504)	6.39372948
10	DNA methylation involved in gamete generation (GO:0043046)	5.88730446
11	regulation of histone H3-K9 methylation (GO:0051570)	5.80653207
12	female gamete generation (GO:0007292)	5.48409141
13	regulation of steroid hormone secretion (GO:2000831)	5.46404572
14	positive regulation of mitotic sister chromatid separation (GO:1901970)	5.43639149
15	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	5.43639149
16	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	5.43639149
17	protein localization to kinetochore (GO:0034501)	5.43258267
18	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	5.40317552
19	oocyte development (GO:0048599)	5.31110921
20	negative regulation of reproductive process (GO:2000242)	5.27725649
21	protein localization to chromosome, centromeric region (GO:0071459)	5.21292542
22	mitotic metaphase plate congression (GO:0007080)	5.14934670
23	positive regulation of gastrulation (GO:2000543)	5.10678569
24	regulation of cell maturation (GO:1903429)	5.06212968
25	positive regulation of chromosome segregation (GO:0051984)	5.06047410
26	negative regulation of histone methylation (GO:0031061)	4.98527595
27	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.98098952
28	glycine transport (GO:0015816)	4.90903155
29	protein kinase C signaling (GO:0070528)	4.87220694
30	mitotic chromosome condensation (GO:0007076)	4.76821096
31	regulation of spindle organization (GO:0090224)	4.75157714
32	attachment of spindle microtubules to kinetochore (GO:0008608)	4.58303528
33	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.49149484
34	centriole replication (GO:0007099)	4.43794011
35	male meiosis I (GO:0007141)	4.39817315
36	reproduction (GO:0000003)	4.39399466
37	establishment of chromosome localization (GO:0051303)	4.34274761
38	metaphase plate congression (GO:0051310)	4.18150475
39	positive regulation of humoral immune response (GO:0002922)	4.16896004
40	primitive streak formation (GO:0090009)	4.15182523
41	gene silencing by RNA (GO:0031047)	4.03132567
42	protein localization to chromosome (GO:0034502)	4.01758029
43	positive regulation of histone methylation (GO:0031062)	3.89826195
44	regulation of steroid hormone biosynthetic process (GO:0090030)	3.86303333
45	meiosis I (GO:0007127)	3.85480098
46	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.82421149
47	somite rostral/caudal axis specification (GO:0032525)	3.80792035
48	binding of sperm to zona pellucida (GO:0007339)	3.80476704
49	regulation of meiosis (GO:0040020)	3.80164645
50	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.72031629
51	CENP-A containing nucleosome assembly (GO:0034080)	3.71635244
52	fertilization (GO:0009566)	3.61973046
53	negative regulation of execution phase of apoptosis (GO:1900118)	3.55006129
54	regulation of corticosteroid hormone secretion (GO:2000846)	3.52784652
55	regulation of histone H3-K4 methylation (GO:0051569)	3.50546235
56	synapsis (GO:0007129)	3.46951573
57	single fertilization (GO:0007338)	3.44851203
58	citrulline biosynthetic process (GO:0019240)	3.44731610
59	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.37917104
60	neuron fate determination (GO:0048664)	3.35407260
61	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.34208615
62	male meiosis (GO:0007140)	3.33641657
63	chromatin remodeling at centromere (GO:0031055)	3.31271367
64	positive regulation of reproductive process (GO:2000243)	3.29800701
65	negative regulation of hormone biosynthetic process (GO:0032353)	3.28532780
66	negative regulation of hormone metabolic process (GO:0032351)	3.27555371
67	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.26377026
68	DNA damage induced protein phosphorylation (GO:0006975)	3.26314524
69	regulation of meiotic cell cycle (GO:0051445)	3.19101488
70	regulation of spindle checkpoint (GO:0090231)	3.18706775
71	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.18200964
72	regulation of histone methylation (GO:0031060)	3.17591957
73	meiotic nuclear division (GO:0007126)	3.16506943
74	synaptonemal complex assembly (GO:0007130)	3.14091459
75	DNA methylation (GO:0006306)	3.13831591
76	DNA alkylation (GO:0006305)	3.13831591
77	meiotic cell cycle process (GO:1903046)	3.12020408
78	phosphorelay signal transduction system (GO:0000160)	3.09072834
79	regulation of reproductive process (GO:2000241)	3.07442374
80	oocyte maturation (GO:0001556)	3.04916345
81	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.00373352
82	labyrinthine layer development (GO:0060711)	2.99318775
83	sperm-egg recognition (GO:0035036)	2.96757098
84	chromosome organization involved in meiosis (GO:0070192)	2.96752388
85	regulation of chromatin silencing (GO:0031935)	2.96241731
86	histone exchange (GO:0043486)	2.94503115
87	positive regulation of hormone biosynthetic process (GO:0046886)	2.91031891
88	centriole assembly (GO:0098534)	2.89766139
89	DNA replication-dependent nucleosome assembly (GO:0006335)	2.89620480
90	DNA replication-dependent nucleosome organization (GO:0034723)	2.89620480
91	relaxation of smooth muscle (GO:0044557)	2.88314906
92	oogenesis (GO:0048477)	2.86898675
93	base-excision repair, AP site formation (GO:0006285)	2.85460029
94	synaptonemal complex organization (GO:0070193)	2.85379102
95	cellular response to pH (GO:0071467)	2.80463027
96	histone phosphorylation (GO:0016572)	2.80099033
97	regulation of mitotic spindle organization (GO:0060236)	2.79813926
98	negative regulation of circadian rhythm (GO:0042754)	2.77251321
99	gene silencing (GO:0016458)	2.75643033
100	DNA replication-independent nucleosome organization (GO:0034724)	2.75248510

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.49035577
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.07896945
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.71831944
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.23721140
5	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.10807701
6	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.10807701
7	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.10807701
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.02075618
9	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.00986169
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.88740924
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.87457010
12	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.62685889
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34113734
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.30057865
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.28870487
16	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.16882315
17	EZH2_22144423_ChIP-Seq_EOC_Human	13.1340376
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84202508
19	GBX2_23144817_ChIP-Seq_PC3_Human	1.78449808
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71113174
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.71006373
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70986862
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.68763826
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61854405
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.59545957
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56589076
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45838523
28	AR_21909140_ChIP-Seq_LNCAP_Human	1.42463826
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.38023264
30	ZNF274_21170338_ChIP-Seq_K562_Hela	1.33187761
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31640858
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29816694
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.29816694
34	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.24065130
35	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23127961
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.22973403
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.21619754
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19227653
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17784594
40	HTT_18923047_ChIP-ChIP_STHdh_Human	1.17325014
41	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.15181654
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13371652
43	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.12069192
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09457567
45	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.08838242
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06169397
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01862068
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00583285
49	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99236513
50	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98420095
51	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.97978611
52	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.97225554
53	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.97180823
54	CBP_21632823_ChIP-Seq_H3396_Human	0.96823366
55	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95841588
56	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.94378472
57	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93800501
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.92977195
59	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.92458650
60	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91597137
61	AR_25329375_ChIP-Seq_VCAP_Human	0.90578980
62	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.88744032
63	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88684578
64	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.87465095
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.85116275
66	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.83608563
67	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.82661715
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.82400624
69	TP53_22573176_ChIP-Seq_HFKS_Human	0.82058997
70	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.81368677
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.81015951
72	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80575677
73	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.80148522
74	MYC_18940864_ChIP-ChIP_HL60_Human	0.80043099
75	TCF4_23295773_ChIP-Seq_U87_Human	0.77857384
76	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.76298903
77	GF1_26923725_Chip-Seq_HPCs_Mouse	0.75562300
78	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.75045093
79	P300_19829295_ChIP-Seq_ESCs_Human	0.75014712
80	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.74215538
81	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.71308317
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.70627855
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.70599712
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.70083844
85	VDR_23849224_ChIP-Seq_CD4+_Human	0.69750077
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.69189290
87	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.68417250
88	NCOR_22424771_ChIP-Seq_293T_Human	0.67366163
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.66377830
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.65812962
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.65219889
92	EWS_26573619_Chip-Seq_HEK293_Human	0.64175095
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.62758180
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.62585579
95	AR_20517297_ChIP-Seq_VCAP_Human	0.60908351
96	VDR_22108803_ChIP-Seq_LS180_Human	0.60813535
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.59435846
98	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.58914840
99	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.58162495
100	TBL1_22424771_ChIP-Seq_293T_Human	0.58010656

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.91371470
2	MP0006292_abnormal_olfactory_placode	5.09787720
3	MP0008789_abnormal_olfactory_epithelium	4.33891559
4	MP0005394_taste/olfaction_phenotype	3.81581210
5	MP0005499_abnormal_olfactory_system	3.81581210
6	MP0008877_abnormal_DNA_methylation	3.73442440
7	MP0002139_abnormal_hepatobiliary_system	3.45277585
8	MP0005360_urolithiasis	3.33054025
9	MP0003693_abnormal_embryo_hatching	3.16835750
10	MP0010030_abnormal_orbit_morphology	3.13860088
11	MP0003890_abnormal_embryonic-extraembry	3.11357156
12	MP0002138_abnormal_hepatobiliary_system	3.06542190
13	MP0005395_other_phenotype	3.00405857
14	MP0003879_abnormal_hair_cell	2.40560220
15	MP0002234_abnormal_pharynx_morphology	2.25241847
16	MP0003183_abnormal_peptide_metabolism	2.15346274
17	MP0003699_abnormal_female_reproductive	2.09780994
18	MP0003077_abnormal_cell_cycle	1.98036946
19	MP0008058_abnormal_DNA_repair	1.95740683
20	MP0005410_abnormal_fertilization	1.93766561
21	MP0010234_abnormal_vibrissa_follicle	1.90952504
22	MP0009379_abnormal_foot_pigmentation	1.90935171
23	MP0001929_abnormal_gametogenesis	1.90924463
24	MP0002160_abnormal_reproductive_system	1.79333615
25	MP0003111_abnormal_nucleus_morphology	1.73275165
26	MP0002210_abnormal_sex_determination	1.72820400
27	MP0010094_abnormal_chromosome_stability	1.60963577
28	MP0001293_anophthalmia	1.56835457
29	MP0000566_synostosis	1.48854224
30	MP0005085_abnormal_gallbladder_physiolo	1.45773515
31	MP0001666_abnormal_nutrient_absorption	1.45544387
32	MP0001986_abnormal_taste_sensitivity	1.43203590
33	MP0008932_abnormal_embryonic_tissue	1.43002977
34	MP0000653_abnormal_sex_gland	1.42821825
35	MP0002161_abnormal_fertility/fecundity	1.42634098
36	MP0001730_embryonic_growth_arrest	1.27959781
37	MP0005503_abnormal_tendon_morphology	1.25432844
38	MP0000631_abnormal_neuroendocrine_gland	1.25308433
39	MP0004957_abnormal_blastocyst_morpholog	1.21933672
40	MP0005389_reproductive_system_phenotype	1.21674489
41	MP0009840_abnormal_foam_cell	1.21546763
42	MP0002233_abnormal_nose_morphology	1.20393882
43	MP0001145_abnormal_male_reproductive	1.10862306
44	MP0005646_abnormal_pituitary_gland	1.09485881
45	MP0000762_abnormal_tongue_morphology	1.07482239
46	MP0010307_abnormal_tumor_latency	1.05447561
47	MP0003950_abnormal_plasma_membrane	1.05377025
48	MP0008057_abnormal_DNA_replication	1.05299787
49	MP0001119_abnormal_female_reproductive	1.04551050
50	MP0003121_genomic_imprinting	1.02680167
51	MP0004142_abnormal_muscle_tone	1.02263061
52	MP0001664_abnormal_digestion	1.01444110
53	MP0003252_abnormal_bile_duct	1.00830028
54	MP0006276_abnormal_autonomic_nervous	0.96249086
55	MP0003698_abnormal_male_reproductive	0.94889264
56	MP0000427_abnormal_hair_cycle	0.91943141
57	MP0000049_abnormal_middle_ear	0.86840068
58	MP0002796_impaired_skin_barrier	0.83536959
59	MP0001984_abnormal_olfaction	0.82101108
60	MP0002638_abnormal_pupillary_reflex	0.79331445
61	MP0005551_abnormal_eye_electrophysiolog	0.79260388
62	MP0005647_abnormal_sex_gland	0.77708384
63	MP0005380_embryogenesis_phenotype	0.76953923
64	MP0001672_abnormal_embryogenesis/_devel	0.76953923
65	MP0002272_abnormal_nervous_system	0.76637711
66	MP0010368_abnormal_lymphatic_system	0.76325437
67	MP0000350_abnormal_cell_proliferation	0.75552918
68	MP0003195_calcinosis	0.70134675
69	MP0001324_abnormal_eye_pigmentation	0.68422491
70	MP0004019_abnormal_vitamin_homeostasis	0.67486715
71	MP0002102_abnormal_ear_morphology	0.66736489
72	MP0003136_yellow_coat_color	0.66514650
73	MP0000750_abnormal_muscle_regeneration	0.64633614
74	MP0003868_abnormal_feces_composition	0.62388743
75	MP0004270_analgesia	0.62233249
76	MP0005409_darkened_coat_color	0.61439529
77	MP0001502_abnormal_circadian_rhythm	0.60847174
78	MP0005075_abnormal_melanosome_morpholog	0.58284096
79	MP0005501_abnormal_skin_physiology	0.58038789
80	MP0003941_abnormal_skin_development	0.57575083
81	MP0001188_hyperpigmentation	0.57005444
82	MP0002734_abnormal_mechanical_nocicepti	0.54919821
83	MP0002089_abnormal_postnatal_growth/wei	0.53930536
84	MP0002127_abnormal_cardiovascular_syste	0.53296553
85	MP0002277_abnormal_respiratory_mucosa	0.52851633
86	MP0004043_abnormal_pH_regulation	0.52827871
87	MP0002084_abnormal_developmental_patter	0.52689111
88	MP0002928_abnormal_bile_duct	0.52063954
89	MP0000678_abnormal_parathyroid_gland	0.51582703
90	MP0008260_abnormal_autophagy	0.51499718
91	MP0003186_abnormal_redox_activity	0.51111983
92	MP0003119_abnormal_digestive_system	0.49790415
93	MP0001529_abnormal_vocalization	0.48004604
94	MP0002108_abnormal_muscle_morphology	0.47324631
95	MP0005319_abnormal_enzyme/_coenzyme	0.47243154
96	MP0002751_abnormal_autonomic_nervous	0.46933532
97	MP0005365_abnormal_bile_salt	0.46258184
98	MP0000015_abnormal_ear_pigmentation	0.46068508
99	MP0001286_abnormal_eye_development	0.45155608
100	MP0003755_abnormal_palate_morphology	0.44716533

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	5.41989776
2	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.31907543
3	Impulsivity (HP:0100710)	5.22916828
4	Abnormal gallbladder physiology (HP:0012438)	5.04662711
5	Cholecystitis (HP:0001082)	5.04662711
6	Septo-optic dysplasia (HP:0100842)	4.94429604
7	Abnormality of abdominal situs (HP:0011620)	4.68848649
8	Abdominal situs inversus (HP:0003363)	4.68848649
9	Male infertility (HP:0003251)	4.52590192
10	Hypophosphatemic rickets (HP:0004912)	4.15510642
11	Absent septum pellucidum (HP:0001331)	4.13923790
12	Anterior segment dysgenesis (HP:0007700)	4.01319661
13	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.98308937
14	Hypoplasia of the fovea (HP:0007750)	3.98308937
15	Osteomalacia (HP:0002749)	3.89351914
16	Lip pit (HP:0100267)	3.84777229
17	Facial hemangioma (HP:0000329)	3.79018400
18	Abnormality of the labia minora (HP:0012880)	3.77619456
19	Chromsome breakage (HP:0040012)	3.67511653
20	Oligodactyly (hands) (HP:0001180)	3.60125805
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.55355900
22	Median cleft lip (HP:0000161)	3.53380672
23	Abnormality of the septum pellucidum (HP:0007375)	3.52349398
24	Infertility (HP:0000789)	3.46074390
25	Abnormality of the fovea (HP:0000493)	3.38024492
26	Azoospermia (HP:0000027)	3.36011367
27	Short tibia (HP:0005736)	3.31787092
28	Malnutrition (HP:0004395)	3.25888498
29	Abnormality of the phalanges of the hallux (HP:0010057)	3.04157539
30	Papillary thyroid carcinoma (HP:0002895)	3.01707386
31	Hypokinesia (HP:0002375)	2.99867318
32	Posterior subcapsular cataract (HP:0007787)	2.96536883
33	Myokymia (HP:0002411)	2.95319793
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.89365514
35	Abnormal spermatogenesis (HP:0008669)	2.85957092
36	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.82291311
37	Oligodactyly (HP:0012165)	2.75284734
38	Premature ovarian failure (HP:0008209)	2.72118865
39	Congenital sensorineural hearing impairment (HP:0008527)	2.71497959
40	Diminished motivation (HP:0000745)	2.70354591
41	Aplasia of the musculature (HP:0100854)	2.67673453
42	Gonadotropin excess (HP:0000837)	2.64584513
43	Partial duplication of thumb phalanx (HP:0009944)	2.63701419
44	Apathy (HP:0000741)	2.63107500
45	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.61701644
46	Partial duplication of the phalanx of hand (HP:0009999)	2.50966975
47	Maternal diabetes (HP:0009800)	2.46697713
48	Enlarged penis (HP:0000040)	2.44567441
49	Wrist flexion contracture (HP:0001239)	2.42029219
50	Intrahepatic cholestasis (HP:0001406)	2.40531716
51	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.37645096
52	Microglossia (HP:0000171)	2.36351488
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.34053739
54	Generalized aminoaciduria (HP:0002909)	2.32535463
55	Capillary hemangiomas (HP:0005306)	2.32518730
56	Aplasia/Hypoplasia of the macula (HP:0008059)	2.31914147
57	Decreased circulating renin level (HP:0003351)	2.31674529
58	Metaphyseal irregularity (HP:0003025)	2.27529103
59	Abnormal lung lobation (HP:0002101)	2.23554022
60	Ankle contracture (HP:0006466)	2.17621912
61	Duplication of thumb phalanx (HP:0009942)	2.16586344
62	Stillbirth (HP:0003826)	2.16412666
63	Urethral obstruction (HP:0000796)	2.15619894
64	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.14278133
65	Proximal tubulopathy (HP:0000114)	2.14273160
66	Abnormal ciliary motility (HP:0012262)	2.13151621
67	Meckel diverticulum (HP:0002245)	2.08329767
68	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.06292524
69	Hypergonadotropic hypogonadism (HP:0000815)	2.04952949
70	Horseshoe kidney (HP:0000085)	2.04541094
71	Dysdiadochokinesis (HP:0002075)	2.03777564
72	Conjunctival telangiectasia (HP:0000524)	1.98978880
73	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.98021724
74	Abnormality of chromosome stability (HP:0003220)	1.96783538
75	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.94974137
76	Muscle stiffness (HP:0003552)	1.94544982
77	Subcapsular cataract (HP:0000523)	1.93850437
78	Abnormality of the ileum (HP:0001549)	1.93410425
79	Spinal cord compression (HP:0002176)	1.93369025
80	Optic nerve hypoplasia (HP:0000609)	1.92663309
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.92088817
82	Lower limb hyperreflexia (HP:0002395)	1.92012363
83	Skin pits (HP:0100276)	1.91680708
84	Sensory axonal neuropathy (HP:0003390)	1.87658278
85	Duodenal stenosis (HP:0100867)	1.85673848
86	Small intestinal stenosis (HP:0012848)	1.85673848
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84694368
88	Abnormality of chromosome segregation (HP:0002916)	1.83246245
89	Hypercortisolism (HP:0001578)	1.83174154
90	Abnormality of the preputium (HP:0100587)	1.82160290
91	Molar tooth sign on MRI (HP:0002419)	1.81886083
92	Abnormality of midbrain morphology (HP:0002418)	1.81886083
93	Abnormality of the labia (HP:0000058)	1.80990361
94	Hyperactive renin-angiotensin system (HP:0000841)	1.79983577
95	Hypoplasia of the uterus (HP:0000013)	1.76702084
96	Megaloblastic anemia (HP:0001889)	1.75924125
97	Absent thumb (HP:0009777)	1.75429913
98	Thyroid carcinoma (HP:0002890)	1.73303046
99	Tubulointerstitial nephritis (HP:0001970)	1.73268047
100	Bifid tongue (HP:0010297)	1.72725725

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	5.64729002
2	MAP3K9	5.09878604
3	MAP3K13	4.38807755
4	TTK	3.34301463
5	NEK6	3.30756675
6	STK24	2.60330258
7	CDK12	2.51916648
8	AURKA	2.50438335
9	TAOK3	2.46884136
10	BRAF	2.41286108
11	MET	2.35151934
12	CDK9	2.22283193
13	MST4	2.14626297
14	PRKCI	2.14186921
15	TRIM28	2.09248469
16	CDC7	2.06022988
17	BUB1	2.05058831
18	MOS	2.00132909
19	LMTK2	1.97112176
20	PLK1	1.74277721
21	RAF1	1.61626290
22	TNIK	1.60310547
23	PBK	1.54346566
24	CDK7	1.48919228
25	STK16	1.36831410
26	KSR2	1.34039319
27	MAP3K8	1.25611983
28	NTRK2	1.22814748
29	STK3	1.21118353
30	MELK	1.20074561
31	PLK3	1.18217593
32	BRSK1	1.17097271
33	NEK2	1.11164877
34	ZAK	1.04805209
35	AURKB	1.03408809
36	CDK19	0.97987588
37	EIF2AK3	0.95832395
38	CHEK1	0.93444860
39	WNK3	0.93120112
40	PTK2	0.90569160
41	PAK1	0.87477595
42	PIM1	0.82845608
43	PRKG1	0.82745201
44	FLT3	0.81373005
45	CSNK1G1	0.79454305
46	DMPK	0.79198954
47	CDK2	0.78187032
48	CHEK2	0.76314314
49	TESK2	0.76161818
50	MAPKAPK3	0.70197854
51	NUAK1	0.68612643
52	NLK	0.66914376
53	LATS2	0.66699096
54	SRPK1	0.65521193
55	ATM	0.64274908
56	MAP3K5	0.59154472
57	PRKCZ	0.58759597
58	KSR1	0.58686545
59	PDK2	0.58642566
60	CDK1	0.57430227
61	VRK1	0.56670730
62	EPHA4	0.56146453
63	CSNK1E	0.55440842
64	TGFBR1	0.54482088
65	TIE1	0.53697125
66	CSNK1G3	0.52100785
67	CSNK1D	0.51792566
68	NEK9	0.51567984
69	BCKDK	0.51470161
70	TESK1	0.49931602
71	MTOR	0.48662230
72	CAMK2A	0.48469335
73	ATR	0.46152777
74	MAPK13	0.45345011
75	CHUK	0.41220711
76	PRKACB	0.39572622
77	BRSK2	0.39136881
78	PRKACA	0.39024440
79	BMPR1B	0.37246210
80	MAP3K4	0.36776045
81	MARK3	0.35700503
82	STK39	0.35221118
83	GSK3B	0.33223062
84	ILK	0.30308867
85	CDK5	0.29623289
86	OXSR1	0.29601032
87	CSNK2A1	0.28887209
88	PRKG2	0.28035776
89	AKT2	0.27534045
90	CDK11A	0.27017121
91	CSNK2A2	0.26321631
92	STK10	0.25504104
93	PKN1	0.24755473
94	CSNK1A1L	0.24243419
95	ACVR1B	0.23233446
96	CDK8	0.22912901
97	LRRK2	0.22905203
98	PRKCA	0.22845157
99	CSNK1G2	0.22763375
100	MAPK1	0.22708795

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.79815916
2	Cell cycle_Homo sapiens_hsa04110	3.66933702
3	Caffeine metabolism_Homo sapiens_hsa00232	3.49944653
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.08327051
5	Base excision repair_Homo sapiens_hsa03410	2.89914424
6	Oocyte meiosis_Homo sapiens_hsa04114	2.87277262
7	Mismatch repair_Homo sapiens_hsa03430	2.81081179
8	RNA degradation_Homo sapiens_hsa03018	2.74498199
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.57316214
10	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.52321289
11	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.10537640
12	Homologous recombination_Homo sapiens_hsa03440	2.08652496
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98170884
14	Folate biosynthesis_Homo sapiens_hsa00790	1.97765979
15	DNA replication_Homo sapiens_hsa03030	1.88785144
16	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.86683681
17	RNA transport_Homo sapiens_hsa03013	1.86632674
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79487742
19	RNA polymerase_Homo sapiens_hsa03020	1.77621129
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.75733051
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.70921433
22	p53 signaling pathway_Homo sapiens_hsa04115	1.70618152
23	Circadian rhythm_Homo sapiens_hsa04710	1.63175552
24	Arginine biosynthesis_Homo sapiens_hsa00220	1.59870989
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.57683337
26	Phototransduction_Homo sapiens_hsa04744	1.52208587
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.43195373
28	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.36051007
29	Regulation of autophagy_Homo sapiens_hsa04140	1.28174051
30	Huntingtons disease_Homo sapiens_hsa05016	1.28054608
31	Olfactory transduction_Homo sapiens_hsa04740	1.26768340
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.22274458
33	Sulfur metabolism_Homo sapiens_hsa00920	1.19377190
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.18643786
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.16019667
36	Ribosome_Homo sapiens_hsa03010	1.14798261
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.14368360
38	Arginine and proline metabolism_Homo sapiens_hsa00330	1.12820588
39	Fatty acid elongation_Homo sapiens_hsa00062	1.09992542
40	Parkinsons disease_Homo sapiens_hsa05012	1.05894334
41	mRNA surveillance pathway_Homo sapiens_hsa03015	1.05151480
42	Glutathione metabolism_Homo sapiens_hsa00480	1.03950567
43	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.02336038
44	Gap junction_Homo sapiens_hsa04540	1.01230191
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.93691879
46	Bile secretion_Homo sapiens_hsa04976	0.91937792
47	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83967571
48	Purine metabolism_Homo sapiens_hsa00230	0.81555300
49	Nicotine addiction_Homo sapiens_hsa05033	0.78564687
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.77280854
51	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74390182
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72557485
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71912658
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.69463139
55	Protein digestion and absorption_Homo sapiens_hsa04974	0.66348037
56	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64515973
57	Taste transduction_Homo sapiens_hsa04742	0.64453878
58	Proteasome_Homo sapiens_hsa03050	0.63108721
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62173750
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60127574
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.58793388
62	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.53641464
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53287268
64	Thyroid cancer_Homo sapiens_hsa05216	0.52784715
65	Histidine metabolism_Homo sapiens_hsa00340	0.52638834
66	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.52510215
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52193195
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50544115
69	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.49768559
70	Spliceosome_Homo sapiens_hsa03040	0.48785075
71	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.47748961
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47625172
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45497967
74	GABAergic synapse_Homo sapiens_hsa04727	0.45299415
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44786413
76	Metabolic pathways_Homo sapiens_hsa01100	0.44230554
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43883184
78	ABC transporters_Homo sapiens_hsa02010	0.42965309
79	Retinol metabolism_Homo sapiens_hsa00830	0.41566432
80	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40009204
81	Adherens junction_Homo sapiens_hsa04520	0.36371527
82	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.36130656
83	Serotonergic synapse_Homo sapiens_hsa04726	0.35178942
84	Tight junction_Homo sapiens_hsa04530	0.33063669
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.32287735
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32191175
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.30680136
88	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28339595
89	Mineral absorption_Homo sapiens_hsa04978	0.27601179
90	Renin-angiotensin system_Homo sapiens_hsa04614	0.27226784
91	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.27197348
92	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26702875
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.25774684
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.24777150
95	Alzheimers disease_Homo sapiens_hsa05010	0.23847076
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.22360975
97	Morphine addiction_Homo sapiens_hsa05032	0.21465728
98	Propanoate metabolism_Homo sapiens_hsa00640	0.21430991
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.20666871
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.20460328

ASS1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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