ASS1P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)9.75865415
2negative regulation of necroptotic process (GO:0060546)8.78589811
3activated T cell proliferation (GO:0050798)8.63293761
4regulation of RIG-I signaling pathway (GO:0039535)8.17750574
5positive regulation of protein homooligomerization (GO:0032464)7.49241988
6regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)7.16812665
7negative regulation of necrotic cell death (GO:0060547)6.93187421
8necroptotic process (GO:0070266)6.71169571
9regulation of necroptotic process (GO:0060544)6.63964114
10regulation of T cell chemotaxis (GO:0010819)5.72707083
11positive regulation of T cell chemotaxis (GO:0010820)5.72707083
12nuclear pore complex assembly (GO:0051292)5.71103812
13cellular hyperosmotic response (GO:0071474)5.59385185
14positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.32674811
15programmed necrotic cell death (GO:0097300)5.16001448
16positive regulation of natural killer cell mediated immunity (GO:0002717)5.08137789
17negative thymic T cell selection (GO:0045060)4.87755667
18necrotic cell death (GO:0070265)4.77246212
19regulation of RNA export from nucleus (GO:0046831)4.59710938
20positive regulation of protein oligomerization (GO:0032461)4.59471000
21T cell mediated immunity (GO:0002456)4.51225968
22nuclear pore organization (GO:0006999)4.49743062
23T cell apoptotic process (GO:0070231)4.46979804
24negative T cell selection (GO:0043383)4.41431323
25pore complex assembly (GO:0046931)4.29084918
26regulation of necrotic cell death (GO:0010939)4.21023901
27negative regulation of interleukin-12 production (GO:0032695)4.20864187
28DNA ligation (GO:0006266)4.20841688
29establishment of integrated proviral latency (GO:0075713)4.19417348
30lymphocyte apoptotic process (GO:0070227)4.16967878
31lung lobe morphogenesis (GO:0060463)3.98487778
32regulation of natural killer cell mediated immunity (GO:0002715)3.97425332
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.97425332
34regulation of protein homooligomerization (GO:0032462)3.93863428
35hyperosmotic salinity response (GO:0042538)3.90574447
36regulation of nucleobase-containing compound transport (GO:0032239)3.83678610
37positive regulation of tolerance induction (GO:0002645)3.76454156
38thymic T cell selection (GO:0045061)3.73805279
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.69257932
40leukocyte mediated cytotoxicity (GO:0001909)3.61777396
41regulation of T cell tolerance induction (GO:0002664)3.60301284
42positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.59929654
43leukocyte apoptotic process (GO:0071887)3.57759388
44pathway-restricted SMAD protein phosphorylation (GO:0060389)3.57602708
45T cell proliferation (GO:0042098)3.56667436
46histone deubiquitination (GO:0016578)3.53146850
47pre-miRNA processing (GO:0031054)3.45245261
48positive regulation of NF-kappaB import into nucleus (GO:0042346)3.45144306
49regulation of lymphocyte chemotaxis (GO:1901623)3.44300718
50cellular response to lithium ion (GO:0071285)3.32947789
51negative regulation of reactive oxygen species metabolic process (GO:2000378)3.30983261
52spliceosomal tri-snRNP complex assembly (GO:0000244)3.28439195
53establishment of viral latency (GO:0019043)3.27346889
54V(D)J recombination (GO:0033151)3.24052653
55regulation of interferon-beta biosynthetic process (GO:0045357)3.21236065
56detection of biotic stimulus (GO:0009595)3.20855422
57myeloid dendritic cell differentiation (GO:0043011)3.18471414
58mitotic sister chromatid cohesion (GO:0007064)3.15562603
59positive regulation of interleukin-10 production (GO:0032733)3.09833387
60CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.09058354
61T cell selection (GO:0045058)3.02674587
62regulation of toll-like receptor signaling pathway (GO:0034121)2.97832753
63T cell homeostasis (GO:0043029)2.97523891
64positive regulation of response to biotic stimulus (GO:0002833)2.96465926
65protein export from nucleus (GO:0006611)2.93613462
66regulation of tolerance induction (GO:0002643)2.87481620
67actin nucleation (GO:0045010)2.86801724
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85660890
69production of molecular mediator of immune response (GO:0002440)2.85506877
70lymphocyte mediated immunity (GO:0002449)2.80688044
71myeloid dendritic cell activation (GO:0001773)2.77100997
72positive regulation of transcription factor import into nucleus (GO:0042993)2.76185978
73T cell lineage commitment (GO:0002360)2.74853174
74meiotic chromosome segregation (GO:0045132)2.72583191
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72217783
76response to host (GO:0075136)2.72217783
77response to host defenses (GO:0052200)2.72217783
78response to host immune response (GO:0052572)2.68630006
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.68630006
80mRNA modification (GO:0016556)2.67469653
81mitochondrial fusion (GO:0008053)2.66313251
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65643500
83positive regulation of cell killing (GO:0031343)2.64049887
84negative regulation of heart growth (GO:0061117)2.62710532
85negative regulation of cardiac muscle tissue growth (GO:0055022)2.62710532
86DNA unwinding involved in DNA replication (GO:0006268)2.62530650
87chromosome condensation (GO:0030261)2.60988506
88mitotic sister chromatid segregation (GO:0000070)2.59885510
89positive regulation of receptor recycling (GO:0001921)2.57858577
90Golgi transport vesicle coating (GO:0048200)2.54959818
91COPI coating of Golgi vesicle (GO:0048205)2.54959818
92protein retention in ER lumen (GO:0006621)2.54710185
93adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.51735352
94positive regulation of T cell migration (GO:2000406)2.50920685
95regulation of protein oligomerization (GO:0032459)2.49738855
96negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.49667402
97positive regulation of response to tumor cell (GO:0002836)11.0629888
98positive regulation of immune response to tumor cell (GO:0002839)11.0629888
99regulation of immune response to tumor cell (GO:0002837)11.0629888
100regulation of response to tumor cell (GO:0002834)11.0629888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.54688866
2E2F7_22180533_ChIP-Seq_HELA_Human4.48878049
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.09550487
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.49771159
5MYC_22102868_ChIP-Seq_BL_Human3.31994532
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17521967
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53185761
8VDR_21846776_ChIP-Seq_THP-1_Human2.27596482
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24145205
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22565722
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17545169
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17420418
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.13915233
14MAF_26560356_Chip-Seq_TH1_Human2.08106222
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.01389913
16CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.81679027
17YY1_21170310_ChIP-Seq_MESCs_Mouse1.77975850
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75216829
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72220635
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71968644
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71754672
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71034686
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.69500276
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69225637
25CIITA_25753668_ChIP-Seq_RAJI_Human1.67885611
26MAF_26560356_Chip-Seq_TH2_Human1.67577929
27XRN2_22483619_ChIP-Seq_HELA_Human1.65335009
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64113282
29TFEB_21752829_ChIP-Seq_HELA_Human1.59774700
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59627407
31TCF7_22412390_ChIP-Seq_EML_Mouse1.59205021
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57204876
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56179882
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55832387
35KDM5A_27292631_Chip-Seq_BREAST_Human1.48518870
36LXR_22292898_ChIP-Seq_THP-1_Human1.48472037
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46573614
38TP53_22127205_ChIP-Seq_IMR90_Human1.43833092
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41137636
40UTX_26944678_Chip-Seq_JUKART_Human1.41001648
41MYB_26560356_Chip-Seq_TH1_Human1.40741454
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39041743
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35960642
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35719721
45CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35493344
46SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34007011
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33614227
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33036965
49CHD1_26751641_Chip-Seq_LNCaP_Human1.31991464
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29951605
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29465025
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28064959
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28053105
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27355960
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25760246
56KDM2B_26808549_Chip-Seq_DND41_Human1.25031520
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22740429
58MYB_26560356_Chip-Seq_TH2_Human1.21738435
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21519972
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20978509
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20450228
62ATF3_27146783_Chip-Seq_COLON_Human1.20369829
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18834437
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18322529
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16369934
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15811391
67P68_20966046_ChIP-Seq_HELA_Human1.14728911
68RACK7_27058665_Chip-Seq_MCF-7_Human1.14506075
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13736756
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13182352
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12397630
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12391514
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12169109
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12148338
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.11989254
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11614774
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10847804
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10350754
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10329413
80CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10194756
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09493559
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08497119
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07242332
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.06948562
85SPI1_23547873_ChIP-Seq_NB4_Human1.06812590
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.05536432
87NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05383579
88FOXP3_21729870_ChIP-Seq_TREG_Human1.05171386
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05060961
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02702190
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01957607
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01920362
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01512679
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.00705422
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00694642
96VDR_24763502_ChIP-Seq_THP-1_Human1.00037284
97DCP1A_22483619_ChIP-Seq_HELA_Human0.99794316
98ETS1_21867929_ChIP-Seq_TH2_Mouse0.99414015
99GABP_19822575_ChIP-Seq_HepG2_Human0.99074549
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97254341

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland5.92218367
2MP0002163_abnormal_gland_morphology5.52917684
3MP0001346_abnormal_lacrimal_gland4.16938949
4MP0009333_abnormal_splenocyte_physiolog3.96355773
5MP0005379_endocrine/exocrine_gland_phen3.48916939
6MP0005451_abnormal_body_composition3.16134068
7MP0004185_abnormal_adipocyte_glucose3.02546832
8MP0000685_abnormal_immune_system2.88206808
9MP0002877_abnormal_melanocyte_morpholog2.78918578
10MP0010352_gastrointestinal_tract_polyps2.49746719
11MP0003763_abnormal_thymus_physiology2.45960241
12MP0005671_abnormal_response_to2.41695129
13MP0006082_CNS_inflammation2.39343750
14MP0008007_abnormal_cellular_replicative2.30624076
15MP0005310_abnormal_salivary_gland2.29948278
16MP0010234_abnormal_vibrissa_follicle2.10778747
17MP0003111_abnormal_nucleus_morphology2.02253911
18MP0002876_abnormal_thyroid_physiology1.98378653
19MP0005083_abnormal_biliary_tract1.93940825
20MP0004947_skin_inflammation1.78459703
21MP0001661_extended_life_span1.71415672
22MP0004957_abnormal_blastocyst_morpholog1.69190305
23MP0002396_abnormal_hematopoietic_system1.67988604
24MP0003303_peritoneal_inflammation1.67270235
25MP0002166_altered_tumor_susceptibility1.60459096
26MP0005076_abnormal_cell_differentiation1.58841758
27MP0005058_abnormal_lysosome_morphology1.54998486
28MP0003693_abnormal_embryo_hatching1.53342125
29MP0004233_abnormal_muscle_weight1.48463419
30MP0002723_abnormal_immune_serum1.45761656
31MP0002398_abnormal_bone_marrow1.45041459
32MP0005387_immune_system_phenotype1.42332013
33MP0001790_abnormal_immune_system1.42332013
34MP0010094_abnormal_chromosome_stability1.41026983
35MP0001800_abnormal_humoral_immune1.40415478
36MP0001835_abnormal_antigen_presentation1.37299857
37MP0002452_abnormal_antigen_presenting1.34420727
38MP0003077_abnormal_cell_cycle1.29796778
39MP0004808_abnormal_hematopoietic_stem1.28330680
40MP0010307_abnormal_tumor_latency1.26835533
41MP0001873_stomach_inflammation1.26738228
42MP0005666_abnormal_adipose_tissue1.22287502
43MP0002006_tumorigenesis1.18385442
44MP0002420_abnormal_adaptive_immunity1.18352219
45MP0003453_abnormal_keratinocyte_physiol1.17758129
46MP0001819_abnormal_immune_cell1.16911055
47MP0005000_abnormal_immune_tolerance1.14354173
48MP0008057_abnormal_DNA_replication1.14084301
49MP0000003_abnormal_adipose_tissue1.12632198
50MP0003705_abnormal_hypodermis_morpholog1.12174492
51MP0005375_adipose_tissue_phenotype1.09035271
52MP0000703_abnormal_thymus_morphology1.08425723
53MP0000689_abnormal_spleen_morphology1.06881945
54MP0002429_abnormal_blood_cell1.06224528
55MP0000716_abnormal_immune_system1.05253275
56MP0000681_abnormal_thyroid_gland1.04660481
57MP0003566_abnormal_cell_adhesion1.01618164
58MP0002405_respiratory_system_inflammati1.01472974
59MP0008961_abnormal_basal_metabolism1.00041109
60MP0002419_abnormal_innate_immunity0.97832651
61MP0001730_embryonic_growth_arrest0.96623824
62MP0000350_abnormal_cell_proliferation0.96358912
63MP0002722_abnormal_immune_system0.95927526
64MP0001915_intracranial_hemorrhage0.95200889
65MP0001216_abnormal_epidermal_layer0.94419095
66MP0003943_abnormal_hepatobiliary_system0.93590915
67MP0000313_abnormal_cell_death0.93232947
68MP0003984_embryonic_growth_retardation0.92837981
69MP0005621_abnormal_cell_physiology0.91102151
70MP0005410_abnormal_fertilization0.90060879
71MP0005380_embryogenesis_phenotype0.89854176
72MP0001672_abnormal_embryogenesis/_devel0.89854176
73MP0002019_abnormal_tumor_incidence0.88739857
74MP0002102_abnormal_ear_morphology0.86560394
75MP0002086_abnormal_extraembryonic_tissu0.85727600
76MP0002088_abnormal_embryonic_growth/wei0.85222856
77MP0002148_abnormal_hypersensitivity_rea0.84889871
78MP0001986_abnormal_taste_sensitivity0.84617478
79MP0003436_decreased_susceptibility_to0.82731872
80MP0005025_abnormal_response_to0.81827515
81MP0003091_abnormal_cell_migration0.81026944
82MP0000609_abnormal_liver_physiology0.79312764
83MP0003300_gastrointestinal_ulcer0.78713502
84MP0002080_prenatal_lethality0.78167325
85MP0001845_abnormal_inflammatory_respons0.77583437
86MP0002089_abnormal_postnatal_growth/wei0.75543032
87MP0001697_abnormal_embryo_size0.71587484
88MP0000490_abnormal_crypts_of0.68801945
89MP0002060_abnormal_skin_morphology0.65785342
90MP0003959_abnormal_lean_body0.62820130
91MP0005220_abnormal_exocrine_pancreas0.62662756
92MP0005384_cellular_phenotype0.62348217
93MP0002998_abnormal_bone_remodeling0.62187088
94MP0005464_abnormal_platelet_physiology0.60053650
95MP0002098_abnormal_vibrissa_morphology0.58918745
96MP0003806_abnormal_nucleotide_metabolis0.58872741
97MP0008932_abnormal_embryonic_tissue0.58712711
98MP0004084_abnormal_cardiac_muscle0.57249943
99MP0009115_abnormal_fat_cell0.56104934
100MP0002796_impaired_skin_barrier0.55525800

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.28392302
2Autoimmune hemolytic anemia (HP:0001890)6.62249015
3Abnormal delayed hypersensitivity skin test (HP:0002963)6.39368870
4Increased IgM level (HP:0003496)6.36982494
5Fatigue (HP:0012378)5.19163453
6Arterial tortuosity (HP:0005116)4.44877308
7Cerebral aneurysm (HP:0004944)4.25179696
8Mediastinal lymphadenopathy (HP:0100721)4.20614502
9Eosinophilia (HP:0001880)3.83243415
10Abnormality of T cell physiology (HP:0011840)3.75154862
11Vascular tortuosity (HP:0004948)3.73632131
12Hypochromic anemia (HP:0001931)3.69875314
13Granulocytopenia (HP:0001913)3.56277564
14Abnormality of the gastric mucosa (HP:0004295)3.33440095
15Abnormality of T cell number (HP:0011839)3.31005632
16Biliary tract neoplasm (HP:0100574)3.28475227
17Hereditary nonpolyposis colorectal carcinoma (HP:0006716)3.20126592
18Pulmonary infiltrates (HP:0002113)3.12380361
19Aortic aneurysm (HP:0004942)3.08999778
20Bicuspid aortic valve (HP:0001647)3.08914483
21Disproportionate tall stature (HP:0001519)2.84173306
22Degeneration of anterior horn cells (HP:0002398)2.82611661
23Abnormality of the anterior horn cell (HP:0006802)2.82611661
24Loss of speech (HP:0002371)2.73979010
25Gastrointestinal carcinoma (HP:0002672)2.71827704
26Malignant gastrointestinal tract tumors (HP:0006749)2.71827704
27Squamous cell carcinoma (HP:0002860)2.60507142
28Abnormality of eosinophils (HP:0001879)2.58350637
29Spinal cord lesions (HP:0100561)2.53243065
30Syringomyelia (HP:0003396)2.53243065
31Metaphyseal cupping (HP:0003021)2.48705235
32Abnormal foot bone ossification (HP:0010675)2.44347965
33Recurrent viral infections (HP:0004429)2.44188310
34Neoplasm of the rectum (HP:0100743)2.41089558
35Abnormality of chromosome segregation (HP:0002916)2.39674669
36Abnormality of T cells (HP:0002843)2.37921248
37Easy fatigability (HP:0003388)2.28631776
38Asymmetry of the thorax (HP:0001555)2.26024920
39Arnold-Chiari malformation (HP:0002308)2.21615495
40Broad face (HP:0000283)2.19306102
41Abnormality of cells of the lymphoid lineage (HP:0012140)2.18614902
42Hypergammaglobulinemia (HP:0010702)2.16908034
43Abnormality of the radial head (HP:0003995)2.15695727
44Large eyes (HP:0001090)2.15475769
45Nonimmune hydrops fetalis (HP:0001790)2.14710211
46Unilateral renal agenesis (HP:0000122)2.14685005
47Aortic dissection (HP:0002647)2.12725340
48Neoplasm of the small intestine (HP:0100833)2.12489517
49Mitral valve prolapse (HP:0001634)2.11910597
50Dilatation of the ascending aorta (HP:0005111)2.10334944
51Overlapping toe (HP:0001845)2.09661476
52Dysmetric saccades (HP:0000641)2.07320492
53Short 4th metacarpal (HP:0010044)2.04689300
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04689300
55Abnormal biliary tract morphology (HP:0012440)2.03852784
56Broad distal phalanx of finger (HP:0009836)2.01922602
57Hyperacusis (HP:0010780)2.01684273
58Short chin (HP:0000331)2.00308488
59Joint swelling (HP:0001386)1.99158140
60Facial hemangioma (HP:0000329)1.96821876
61Segmental peripheral demyelination/remyelination (HP:0003481)1.95859112
62Cutaneous melanoma (HP:0012056)1.93854524
63Dislocated radial head (HP:0003083)1.93171734
64Uterine neoplasm (HP:0010784)1.92092067
65Reticulocytosis (HP:0001923)1.91835545
66Subacute progressive viral hepatitis (HP:0006572)1.86908439
67Sandal gap (HP:0001852)1.85729347
68Skull defect (HP:0001362)1.84678429
693-Methylglutaconic aciduria (HP:0003535)1.84111709
70Deep palmar crease (HP:0006191)1.83992430
7111 pairs of ribs (HP:0000878)1.83560661
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78162269
73Spinal muscular atrophy (HP:0007269)1.76922627
74Urticaria (HP:0001025)1.72862598
75Pseudobulbar signs (HP:0002200)1.72322373
76Duplicated collecting system (HP:0000081)1.69445439
77Slow saccadic eye movements (HP:0000514)1.67251547
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65136065
79Myocardial infarction (HP:0001658)1.64118737
80Leukocytosis (HP:0001974)1.62691592
81Thin bony cortex (HP:0002753)1.61469202
82Verrucae (HP:0200043)1.59029491
83Papilloma (HP:0012740)1.59029491
84Basal cell carcinoma (HP:0002671)1.58483018
85Ulnar bowing (HP:0003031)1.57835228
86Chronic otitis media (HP:0000389)1.56285724
87Hypoplasia of the thymus (HP:0000778)1.55505407
88Vertebral compression fractures (HP:0002953)1.55362146
89Broad palm (HP:0001169)1.55268182
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.53812278
91Abnormality of the fingertips (HP:0001211)1.50565592
92Prominent nose (HP:0000448)1.50272430
93Long eyelashes (HP:0000527)1.50171782
94Striae distensae (HP:0001065)1.49865201
95Aneurysm (HP:0002617)1.47947461
96Long clavicles (HP:0000890)1.47944132
97Recurrent fungal infections (HP:0002841)1.47240194
98Hepatitis (HP:0012115)1.47197079
99Neoplasm of the adrenal cortex (HP:0100641)1.44628638
100Limb hypertonia (HP:0002509)1.44373287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR6.17922040
2TGFBR24.54909915
3SMG13.60905610
4EPHB13.48140666
5IRAK33.36381484
6KSR12.41709593
7MAP3K142.40830154
8TAOK22.31069431
9MAP3K102.21734109
10CDK122.17258230
11PRPF4B2.12706491
12FES2.12195893
13MAP4K12.03486731
14TRIB32.02377782
15MAP2K32.01336706
16EEF2K1.98980304
17TSSK61.98558363
18MARK31.89965902
19CLK11.72104986
20NME21.51571089
21CAMK1D1.51522807
22AKT31.49386800
23ICK1.44019569
24PAK41.35441802
25MAP3K31.33942445
26TAOK11.31670360
27FER1.26478807
28RPS6KB21.25609412
29MAP3K11.20913996
30TAF11.19226279
31CDK41.18960627
32MAP3K111.17572236
33BUB11.16702383
34STK31.15222903
35FGFR41.12365805
36KSR21.10717432
37BRAF1.08294062
38FGFR31.06333937
39MAP3K81.01074859
40CAMK1G0.94904773
41CHEK10.89686807
42PLK40.89298270
43STK40.85954042
44IRAK20.85596404
45EPHA30.85518562
46PIM10.84339452
47BRD40.80675156
48CDK70.74937086
49BTK0.74397149
50MAP3K130.73014728
51MAPKAPK20.72156123
52TTK0.71843511
53ERN10.67638270
54SIK30.67425661
55SRPK10.65686086
56MTOR0.64727537
57PASK0.64483016
58NEK20.64313318
59ATR0.57503200
60CDK60.56848748
61STK100.55041979
62SIK10.54468819
63HIPK20.54022549
64IRAK40.52829116
65MAPK110.51853928
66ZAP700.51786052
67MST1R0.50342724
68MELK0.48291766
69CSK0.47178309
70CDK90.47100459
71TBK10.46264887
72EIF2AK30.45207353
73VRK20.44221273
74PRKCI0.41858386
75JAK10.40622453
76TTN0.40066100
77RPS6KL10.39373488
78RPS6KC10.39373488
79IRAK10.39016469
80IKBKB0.36731531
81PTK60.35105810
82NEK60.34123059
83EPHA20.33885173
84BRSK10.33555925
85EIF2AK20.33285660
86RPS6KA60.32806851
87CDK20.32117995
88DDR20.31424051
89CHEK20.27672186
90TEC0.27296930
91LATS20.25218255
92LYN0.25175186
93JAK30.24380614
94PAK10.24141312
95STK110.24093258
96TESK20.23413995
97NEK10.22493281
98PDPK10.21124095
99CDC70.20977544
100WNK10.20593181

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.76961760
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.78961649
3Small cell lung cancer_Homo sapiens_hsa052222.21316853
4Thyroid cancer_Homo sapiens_hsa052162.15264627
5Chronic myeloid leukemia_Homo sapiens_hsa052202.15104291
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14412182
7Measles_Homo sapiens_hsa051622.07169280
8TNF signaling pathway_Homo sapiens_hsa046682.07035056
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05497278
10Apoptosis_Homo sapiens_hsa042102.04618982
11Pancreatic cancer_Homo sapiens_hsa052122.01475345
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90149467
13Hepatitis B_Homo sapiens_hsa051611.82545516
14N-Glycan biosynthesis_Homo sapiens_hsa005101.79858260
15Non-small cell lung cancer_Homo sapiens_hsa052231.79359202
16Acute myeloid leukemia_Homo sapiens_hsa052211.76029959
17Influenza A_Homo sapiens_hsa051641.74727233
18Herpes simplex infection_Homo sapiens_hsa051681.73416143
19Bladder cancer_Homo sapiens_hsa052191.62903148
20p53 signaling pathway_Homo sapiens_hsa041151.61232249
21Colorectal cancer_Homo sapiens_hsa052101.60114113
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50966337
23Toxoplasmosis_Homo sapiens_hsa051451.50773547
24mRNA surveillance pathway_Homo sapiens_hsa030151.50713864
25RNA transport_Homo sapiens_hsa030131.50502521
26DNA replication_Homo sapiens_hsa030301.44580891
27Mismatch repair_Homo sapiens_hsa034301.44026071
28Spliceosome_Homo sapiens_hsa030401.42120684
29B cell receptor signaling pathway_Homo sapiens_hsa046621.39257088
30Graft-versus-host disease_Homo sapiens_hsa053321.36872263
31Cell cycle_Homo sapiens_hsa041101.34624768
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33950797
33Allograft rejection_Homo sapiens_hsa053301.28501084
34African trypanosomiasis_Homo sapiens_hsa051431.25276262
35Autoimmune thyroid disease_Homo sapiens_hsa053201.23514583
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23495193
37mTOR signaling pathway_Homo sapiens_hsa041501.22386204
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22072262
39Selenocompound metabolism_Homo sapiens_hsa004501.18703028
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16177804
41T cell receptor signaling pathway_Homo sapiens_hsa046601.13590497
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12651184
43VEGF signaling pathway_Homo sapiens_hsa043701.09911300
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08272346
45Viral carcinogenesis_Homo sapiens_hsa052031.07692994
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.07166563
47Osteoclast differentiation_Homo sapiens_hsa043801.06679020
48Prostate cancer_Homo sapiens_hsa052151.05653309
49Endometrial cancer_Homo sapiens_hsa052131.04356133
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01968406
51Antigen processing and presentation_Homo sapiens_hsa046120.98557951
52Epstein-Barr virus infection_Homo sapiens_hsa051690.97441236
53MicroRNAs in cancer_Homo sapiens_hsa052060.95934972
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95910472
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94425580
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93198868
57HTLV-I infection_Homo sapiens_hsa051660.83004988
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.82521109
59Type I diabetes mellitus_Homo sapiens_hsa049400.82413718
60Focal adhesion_Homo sapiens_hsa045100.81351764
61Proteoglycans in cancer_Homo sapiens_hsa052050.77070226
62Pathways in cancer_Homo sapiens_hsa052000.75191668
63FoxO signaling pathway_Homo sapiens_hsa040680.74554943
64Notch signaling pathway_Homo sapiens_hsa043300.74034827
65Hepatitis C_Homo sapiens_hsa051600.71619106
66Glioma_Homo sapiens_hsa052140.71217136
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71177683
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.70780228
69Prolactin signaling pathway_Homo sapiens_hsa049170.69005102
70Shigellosis_Homo sapiens_hsa051310.67383055
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66332715
72Nucleotide excision repair_Homo sapiens_hsa034200.64037176
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62927871
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.62854969
75Primary immunodeficiency_Homo sapiens_hsa053400.61571516
76Adherens junction_Homo sapiens_hsa045200.59624423
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59309284
78Legionellosis_Homo sapiens_hsa051340.58357096
79MAPK signaling pathway_Homo sapiens_hsa040100.57147028
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.55721526
81Renal cell carcinoma_Homo sapiens_hsa052110.54240306
82Other glycan degradation_Homo sapiens_hsa005110.53781066
83Sulfur relay system_Homo sapiens_hsa041220.51672129
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48955027
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48012771
86Lysine degradation_Homo sapiens_hsa003100.47488381
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.46761311
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43879953
89Chemokine signaling pathway_Homo sapiens_hsa040620.42756899
90One carbon pool by folate_Homo sapiens_hsa006700.42632168
91ErbB signaling pathway_Homo sapiens_hsa040120.42399293
92Prion diseases_Homo sapiens_hsa050200.41463455
93Inositol phosphate metabolism_Homo sapiens_hsa005620.39823470
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37284056
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37109719
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36696905
97Hippo signaling pathway_Homo sapiens_hsa043900.33502633
98TGF-beta signaling pathway_Homo sapiens_hsa043500.33063643
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.31267213
100Insulin signaling pathway_Homo sapiens_hsa049100.30481307

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