Rank | Gene Set | Z-score |
---|---|---|
1 | NIK/NF-kappaB signaling (GO:0038061) | 9.75865415 |
2 | negative regulation of necroptotic process (GO:0060546) | 8.78589811 |
3 | activated T cell proliferation (GO:0050798) | 8.63293761 |
4 | regulation of RIG-I signaling pathway (GO:0039535) | 8.17750574 |
5 | positive regulation of protein homooligomerization (GO:0032464) | 7.49241988 |
6 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 7.16812665 |
7 | negative regulation of necrotic cell death (GO:0060547) | 6.93187421 |
8 | necroptotic process (GO:0070266) | 6.71169571 |
9 | regulation of necroptotic process (GO:0060544) | 6.63964114 |
10 | regulation of T cell chemotaxis (GO:0010819) | 5.72707083 |
11 | positive regulation of T cell chemotaxis (GO:0010820) | 5.72707083 |
12 | nuclear pore complex assembly (GO:0051292) | 5.71103812 |
13 | cellular hyperosmotic response (GO:0071474) | 5.59385185 |
14 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 5.32674811 |
15 | programmed necrotic cell death (GO:0097300) | 5.16001448 |
16 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 5.08137789 |
17 | negative thymic T cell selection (GO:0045060) | 4.87755667 |
18 | necrotic cell death (GO:0070265) | 4.77246212 |
19 | regulation of RNA export from nucleus (GO:0046831) | 4.59710938 |
20 | positive regulation of protein oligomerization (GO:0032461) | 4.59471000 |
21 | T cell mediated immunity (GO:0002456) | 4.51225968 |
22 | nuclear pore organization (GO:0006999) | 4.49743062 |
23 | T cell apoptotic process (GO:0070231) | 4.46979804 |
24 | negative T cell selection (GO:0043383) | 4.41431323 |
25 | pore complex assembly (GO:0046931) | 4.29084918 |
26 | regulation of necrotic cell death (GO:0010939) | 4.21023901 |
27 | negative regulation of interleukin-12 production (GO:0032695) | 4.20864187 |
28 | DNA ligation (GO:0006266) | 4.20841688 |
29 | establishment of integrated proviral latency (GO:0075713) | 4.19417348 |
30 | lymphocyte apoptotic process (GO:0070227) | 4.16967878 |
31 | lung lobe morphogenesis (GO:0060463) | 3.98487778 |
32 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.97425332 |
33 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.97425332 |
34 | regulation of protein homooligomerization (GO:0032462) | 3.93863428 |
35 | hyperosmotic salinity response (GO:0042538) | 3.90574447 |
36 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.83678610 |
37 | positive regulation of tolerance induction (GO:0002645) | 3.76454156 |
38 | thymic T cell selection (GO:0045061) | 3.73805279 |
39 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.69257932 |
40 | leukocyte mediated cytotoxicity (GO:0001909) | 3.61777396 |
41 | regulation of T cell tolerance induction (GO:0002664) | 3.60301284 |
42 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) | 3.59929654 |
43 | leukocyte apoptotic process (GO:0071887) | 3.57759388 |
44 | pathway-restricted SMAD protein phosphorylation (GO:0060389) | 3.57602708 |
45 | T cell proliferation (GO:0042098) | 3.56667436 |
46 | histone deubiquitination (GO:0016578) | 3.53146850 |
47 | pre-miRNA processing (GO:0031054) | 3.45245261 |
48 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.45144306 |
49 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.44300718 |
50 | cellular response to lithium ion (GO:0071285) | 3.32947789 |
51 | negative regulation of reactive oxygen species metabolic process (GO:2000378) | 3.30983261 |
52 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.28439195 |
53 | establishment of viral latency (GO:0019043) | 3.27346889 |
54 | V(D)J recombination (GO:0033151) | 3.24052653 |
55 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.21236065 |
56 | detection of biotic stimulus (GO:0009595) | 3.20855422 |
57 | myeloid dendritic cell differentiation (GO:0043011) | 3.18471414 |
58 | mitotic sister chromatid cohesion (GO:0007064) | 3.15562603 |
59 | positive regulation of interleukin-10 production (GO:0032733) | 3.09833387 |
60 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.09058354 |
61 | T cell selection (GO:0045058) | 3.02674587 |
62 | regulation of toll-like receptor signaling pathway (GO:0034121) | 2.97832753 |
63 | T cell homeostasis (GO:0043029) | 2.97523891 |
64 | positive regulation of response to biotic stimulus (GO:0002833) | 2.96465926 |
65 | protein export from nucleus (GO:0006611) | 2.93613462 |
66 | regulation of tolerance induction (GO:0002643) | 2.87481620 |
67 | actin nucleation (GO:0045010) | 2.86801724 |
68 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.85660890 |
69 | production of molecular mediator of immune response (GO:0002440) | 2.85506877 |
70 | lymphocyte mediated immunity (GO:0002449) | 2.80688044 |
71 | myeloid dendritic cell activation (GO:0001773) | 2.77100997 |
72 | positive regulation of transcription factor import into nucleus (GO:0042993) | 2.76185978 |
73 | T cell lineage commitment (GO:0002360) | 2.74853174 |
74 | meiotic chromosome segregation (GO:0045132) | 2.72583191 |
75 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.72217783 |
76 | response to host (GO:0075136) | 2.72217783 |
77 | response to host defenses (GO:0052200) | 2.72217783 |
78 | response to host immune response (GO:0052572) | 2.68630006 |
79 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.68630006 |
80 | mRNA modification (GO:0016556) | 2.67469653 |
81 | mitochondrial fusion (GO:0008053) | 2.66313251 |
82 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.65643500 |
83 | positive regulation of cell killing (GO:0031343) | 2.64049887 |
84 | negative regulation of heart growth (GO:0061117) | 2.62710532 |
85 | negative regulation of cardiac muscle tissue growth (GO:0055022) | 2.62710532 |
86 | DNA unwinding involved in DNA replication (GO:0006268) | 2.62530650 |
87 | chromosome condensation (GO:0030261) | 2.60988506 |
88 | mitotic sister chromatid segregation (GO:0000070) | 2.59885510 |
89 | positive regulation of receptor recycling (GO:0001921) | 2.57858577 |
90 | Golgi transport vesicle coating (GO:0048200) | 2.54959818 |
91 | COPI coating of Golgi vesicle (GO:0048205) | 2.54959818 |
92 | protein retention in ER lumen (GO:0006621) | 2.54710185 |
93 | adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli | 2.51735352 |
94 | positive regulation of T cell migration (GO:2000406) | 2.50920685 |
95 | regulation of protein oligomerization (GO:0032459) | 2.49738855 |
96 | negative regulation of epidermal growth factor-activated receptor activity (GO:0007175) | 2.49667402 |
97 | positive regulation of response to tumor cell (GO:0002836) | 11.0629888 |
98 | positive regulation of immune response to tumor cell (GO:0002839) | 11.0629888 |
99 | regulation of immune response to tumor cell (GO:0002837) | 11.0629888 |
100 | regulation of response to tumor cell (GO:0002834) | 11.0629888 |
Rank | Gene Set | Z-score |
---|---|---|
1 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.54688866 |
2 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.48878049 |
3 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 4.09550487 |
4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.49771159 |
5 | MYC_22102868_ChIP-Seq_BL_Human | 3.31994532 |
6 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.17521967 |
7 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.53185761 |
8 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.27596482 |
9 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.24145205 |
10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.22565722 |
11 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.17545169 |
12 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.17420418 |
13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.13915233 |
14 | MAF_26560356_Chip-Seq_TH1_Human | 2.08106222 |
15 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.01389913 |
16 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.81679027 |
17 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.77975850 |
18 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.75216829 |
19 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.72220635 |
20 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.71968644 |
21 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.71754672 |
22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.71034686 |
23 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.69500276 |
24 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.69225637 |
25 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.67885611 |
26 | MAF_26560356_Chip-Seq_TH2_Human | 1.67577929 |
27 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.65335009 |
28 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.64113282 |
29 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.59774700 |
30 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.59627407 |
31 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.59205021 |
32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.57204876 |
33 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.56179882 |
34 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.55832387 |
35 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.48518870 |
36 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.48472037 |
37 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.46573614 |
38 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.43833092 |
39 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.41137636 |
40 | UTX_26944678_Chip-Seq_JUKART_Human | 1.41001648 |
41 | MYB_26560356_Chip-Seq_TH1_Human | 1.40741454 |
42 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.39041743 |
43 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.35960642 |
44 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.35719721 |
45 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.35493344 |
46 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.34007011 |
47 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.33614227 |
48 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.33036965 |
49 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.31991464 |
50 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.29951605 |
51 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.29465025 |
52 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.28064959 |
53 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28053105 |
54 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.27355960 |
55 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.25760246 |
56 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.25031520 |
57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.22740429 |
58 | MYB_26560356_Chip-Seq_TH2_Human | 1.21738435 |
59 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.21519972 |
60 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.20978509 |
61 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.20450228 |
62 | ATF3_27146783_Chip-Seq_COLON_Human | 1.20369829 |
63 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.18834437 |
64 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.18322529 |
65 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.16369934 |
66 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.15811391 |
67 | P68_20966046_ChIP-Seq_HELA_Human | 1.14728911 |
68 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.14506075 |
69 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.13736756 |
70 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.13182352 |
71 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.12397630 |
72 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.12391514 |
73 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.12169109 |
74 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12148338 |
75 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.11989254 |
76 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11614774 |
77 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.10847804 |
78 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.10350754 |
79 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10329413 |
80 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.10194756 |
81 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.09493559 |
82 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.08497119 |
83 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.07242332 |
84 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.06948562 |
85 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.06812590 |
86 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.05536432 |
87 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.05383579 |
88 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.05171386 |
89 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05060961 |
90 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.02702190 |
91 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.01957607 |
92 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.01920362 |
93 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01512679 |
94 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.00705422 |
95 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.00694642 |
96 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.00037284 |
97 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.99794316 |
98 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 0.99414015 |
99 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.99074549 |
100 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.97254341 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001348_abnormal_lacrimal_gland | 5.92218367 |
2 | MP0002163_abnormal_gland_morphology | 5.52917684 |
3 | MP0001346_abnormal_lacrimal_gland | 4.16938949 |
4 | MP0009333_abnormal_splenocyte_physiolog | 3.96355773 |
5 | MP0005379_endocrine/exocrine_gland_phen | 3.48916939 |
6 | MP0005451_abnormal_body_composition | 3.16134068 |
7 | MP0004185_abnormal_adipocyte_glucose | 3.02546832 |
8 | MP0000685_abnormal_immune_system | 2.88206808 |
9 | MP0002877_abnormal_melanocyte_morpholog | 2.78918578 |
10 | MP0010352_gastrointestinal_tract_polyps | 2.49746719 |
11 | MP0003763_abnormal_thymus_physiology | 2.45960241 |
12 | MP0005671_abnormal_response_to | 2.41695129 |
13 | MP0006082_CNS_inflammation | 2.39343750 |
14 | MP0008007_abnormal_cellular_replicative | 2.30624076 |
15 | MP0005310_abnormal_salivary_gland | 2.29948278 |
16 | MP0010234_abnormal_vibrissa_follicle | 2.10778747 |
17 | MP0003111_abnormal_nucleus_morphology | 2.02253911 |
18 | MP0002876_abnormal_thyroid_physiology | 1.98378653 |
19 | MP0005083_abnormal_biliary_tract | 1.93940825 |
20 | MP0004947_skin_inflammation | 1.78459703 |
21 | MP0001661_extended_life_span | 1.71415672 |
22 | MP0004957_abnormal_blastocyst_morpholog | 1.69190305 |
23 | MP0002396_abnormal_hematopoietic_system | 1.67988604 |
24 | MP0003303_peritoneal_inflammation | 1.67270235 |
25 | MP0002166_altered_tumor_susceptibility | 1.60459096 |
26 | MP0005076_abnormal_cell_differentiation | 1.58841758 |
27 | MP0005058_abnormal_lysosome_morphology | 1.54998486 |
28 | MP0003693_abnormal_embryo_hatching | 1.53342125 |
29 | MP0004233_abnormal_muscle_weight | 1.48463419 |
30 | MP0002723_abnormal_immune_serum | 1.45761656 |
31 | MP0002398_abnormal_bone_marrow | 1.45041459 |
32 | MP0005387_immune_system_phenotype | 1.42332013 |
33 | MP0001790_abnormal_immune_system | 1.42332013 |
34 | MP0010094_abnormal_chromosome_stability | 1.41026983 |
35 | MP0001800_abnormal_humoral_immune | 1.40415478 |
36 | MP0001835_abnormal_antigen_presentation | 1.37299857 |
37 | MP0002452_abnormal_antigen_presenting | 1.34420727 |
38 | MP0003077_abnormal_cell_cycle | 1.29796778 |
39 | MP0004808_abnormal_hematopoietic_stem | 1.28330680 |
40 | MP0010307_abnormal_tumor_latency | 1.26835533 |
41 | MP0001873_stomach_inflammation | 1.26738228 |
42 | MP0005666_abnormal_adipose_tissue | 1.22287502 |
43 | MP0002006_tumorigenesis | 1.18385442 |
44 | MP0002420_abnormal_adaptive_immunity | 1.18352219 |
45 | MP0003453_abnormal_keratinocyte_physiol | 1.17758129 |
46 | MP0001819_abnormal_immune_cell | 1.16911055 |
47 | MP0005000_abnormal_immune_tolerance | 1.14354173 |
48 | MP0008057_abnormal_DNA_replication | 1.14084301 |
49 | MP0000003_abnormal_adipose_tissue | 1.12632198 |
50 | MP0003705_abnormal_hypodermis_morpholog | 1.12174492 |
51 | MP0005375_adipose_tissue_phenotype | 1.09035271 |
52 | MP0000703_abnormal_thymus_morphology | 1.08425723 |
53 | MP0000689_abnormal_spleen_morphology | 1.06881945 |
54 | MP0002429_abnormal_blood_cell | 1.06224528 |
55 | MP0000716_abnormal_immune_system | 1.05253275 |
56 | MP0000681_abnormal_thyroid_gland | 1.04660481 |
57 | MP0003566_abnormal_cell_adhesion | 1.01618164 |
58 | MP0002405_respiratory_system_inflammati | 1.01472974 |
59 | MP0008961_abnormal_basal_metabolism | 1.00041109 |
60 | MP0002419_abnormal_innate_immunity | 0.97832651 |
61 | MP0001730_embryonic_growth_arrest | 0.96623824 |
62 | MP0000350_abnormal_cell_proliferation | 0.96358912 |
63 | MP0002722_abnormal_immune_system | 0.95927526 |
64 | MP0001915_intracranial_hemorrhage | 0.95200889 |
65 | MP0001216_abnormal_epidermal_layer | 0.94419095 |
66 | MP0003943_abnormal_hepatobiliary_system | 0.93590915 |
67 | MP0000313_abnormal_cell_death | 0.93232947 |
68 | MP0003984_embryonic_growth_retardation | 0.92837981 |
69 | MP0005621_abnormal_cell_physiology | 0.91102151 |
70 | MP0005410_abnormal_fertilization | 0.90060879 |
71 | MP0005380_embryogenesis_phenotype | 0.89854176 |
72 | MP0001672_abnormal_embryogenesis/_devel | 0.89854176 |
73 | MP0002019_abnormal_tumor_incidence | 0.88739857 |
74 | MP0002102_abnormal_ear_morphology | 0.86560394 |
75 | MP0002086_abnormal_extraembryonic_tissu | 0.85727600 |
76 | MP0002088_abnormal_embryonic_growth/wei | 0.85222856 |
77 | MP0002148_abnormal_hypersensitivity_rea | 0.84889871 |
78 | MP0001986_abnormal_taste_sensitivity | 0.84617478 |
79 | MP0003436_decreased_susceptibility_to | 0.82731872 |
80 | MP0005025_abnormal_response_to | 0.81827515 |
81 | MP0003091_abnormal_cell_migration | 0.81026944 |
82 | MP0000609_abnormal_liver_physiology | 0.79312764 |
83 | MP0003300_gastrointestinal_ulcer | 0.78713502 |
84 | MP0002080_prenatal_lethality | 0.78167325 |
85 | MP0001845_abnormal_inflammatory_respons | 0.77583437 |
86 | MP0002089_abnormal_postnatal_growth/wei | 0.75543032 |
87 | MP0001697_abnormal_embryo_size | 0.71587484 |
88 | MP0000490_abnormal_crypts_of | 0.68801945 |
89 | MP0002060_abnormal_skin_morphology | 0.65785342 |
90 | MP0003959_abnormal_lean_body | 0.62820130 |
91 | MP0005220_abnormal_exocrine_pancreas | 0.62662756 |
92 | MP0005384_cellular_phenotype | 0.62348217 |
93 | MP0002998_abnormal_bone_remodeling | 0.62187088 |
94 | MP0005464_abnormal_platelet_physiology | 0.60053650 |
95 | MP0002098_abnormal_vibrissa_morphology | 0.58918745 |
96 | MP0003806_abnormal_nucleotide_metabolis | 0.58872741 |
97 | MP0008932_abnormal_embryonic_tissue | 0.58712711 |
98 | MP0004084_abnormal_cardiac_muscle | 0.57249943 |
99 | MP0009115_abnormal_fat_cell | 0.56104934 |
100 | MP0002796_impaired_skin_barrier | 0.55525800 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Autoimmune thrombocytopenia (HP:0001973) | 7.28392302 |
2 | Autoimmune hemolytic anemia (HP:0001890) | 6.62249015 |
3 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 6.39368870 |
4 | Increased IgM level (HP:0003496) | 6.36982494 |
5 | Fatigue (HP:0012378) | 5.19163453 |
6 | Arterial tortuosity (HP:0005116) | 4.44877308 |
7 | Cerebral aneurysm (HP:0004944) | 4.25179696 |
8 | Mediastinal lymphadenopathy (HP:0100721) | 4.20614502 |
9 | Eosinophilia (HP:0001880) | 3.83243415 |
10 | Abnormality of T cell physiology (HP:0011840) | 3.75154862 |
11 | Vascular tortuosity (HP:0004948) | 3.73632131 |
12 | Hypochromic anemia (HP:0001931) | 3.69875314 |
13 | Granulocytopenia (HP:0001913) | 3.56277564 |
14 | Abnormality of the gastric mucosa (HP:0004295) | 3.33440095 |
15 | Abnormality of T cell number (HP:0011839) | 3.31005632 |
16 | Biliary tract neoplasm (HP:0100574) | 3.28475227 |
17 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 3.20126592 |
18 | Pulmonary infiltrates (HP:0002113) | 3.12380361 |
19 | Aortic aneurysm (HP:0004942) | 3.08999778 |
20 | Bicuspid aortic valve (HP:0001647) | 3.08914483 |
21 | Disproportionate tall stature (HP:0001519) | 2.84173306 |
22 | Degeneration of anterior horn cells (HP:0002398) | 2.82611661 |
23 | Abnormality of the anterior horn cell (HP:0006802) | 2.82611661 |
24 | Loss of speech (HP:0002371) | 2.73979010 |
25 | Gastrointestinal carcinoma (HP:0002672) | 2.71827704 |
26 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.71827704 |
27 | Squamous cell carcinoma (HP:0002860) | 2.60507142 |
28 | Abnormality of eosinophils (HP:0001879) | 2.58350637 |
29 | Spinal cord lesions (HP:0100561) | 2.53243065 |
30 | Syringomyelia (HP:0003396) | 2.53243065 |
31 | Metaphyseal cupping (HP:0003021) | 2.48705235 |
32 | Abnormal foot bone ossification (HP:0010675) | 2.44347965 |
33 | Recurrent viral infections (HP:0004429) | 2.44188310 |
34 | Neoplasm of the rectum (HP:0100743) | 2.41089558 |
35 | Abnormality of chromosome segregation (HP:0002916) | 2.39674669 |
36 | Abnormality of T cells (HP:0002843) | 2.37921248 |
37 | Easy fatigability (HP:0003388) | 2.28631776 |
38 | Asymmetry of the thorax (HP:0001555) | 2.26024920 |
39 | Arnold-Chiari malformation (HP:0002308) | 2.21615495 |
40 | Broad face (HP:0000283) | 2.19306102 |
41 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.18614902 |
42 | Hypergammaglobulinemia (HP:0010702) | 2.16908034 |
43 | Abnormality of the radial head (HP:0003995) | 2.15695727 |
44 | Large eyes (HP:0001090) | 2.15475769 |
45 | Nonimmune hydrops fetalis (HP:0001790) | 2.14710211 |
46 | Unilateral renal agenesis (HP:0000122) | 2.14685005 |
47 | Aortic dissection (HP:0002647) | 2.12725340 |
48 | Neoplasm of the small intestine (HP:0100833) | 2.12489517 |
49 | Mitral valve prolapse (HP:0001634) | 2.11910597 |
50 | Dilatation of the ascending aorta (HP:0005111) | 2.10334944 |
51 | Overlapping toe (HP:0001845) | 2.09661476 |
52 | Dysmetric saccades (HP:0000641) | 2.07320492 |
53 | Short 4th metacarpal (HP:0010044) | 2.04689300 |
54 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.04689300 |
55 | Abnormal biliary tract morphology (HP:0012440) | 2.03852784 |
56 | Broad distal phalanx of finger (HP:0009836) | 2.01922602 |
57 | Hyperacusis (HP:0010780) | 2.01684273 |
58 | Short chin (HP:0000331) | 2.00308488 |
59 | Joint swelling (HP:0001386) | 1.99158140 |
60 | Facial hemangioma (HP:0000329) | 1.96821876 |
61 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.95859112 |
62 | Cutaneous melanoma (HP:0012056) | 1.93854524 |
63 | Dislocated radial head (HP:0003083) | 1.93171734 |
64 | Uterine neoplasm (HP:0010784) | 1.92092067 |
65 | Reticulocytosis (HP:0001923) | 1.91835545 |
66 | Subacute progressive viral hepatitis (HP:0006572) | 1.86908439 |
67 | Sandal gap (HP:0001852) | 1.85729347 |
68 | Skull defect (HP:0001362) | 1.84678429 |
69 | 3-Methylglutaconic aciduria (HP:0003535) | 1.84111709 |
70 | Deep palmar crease (HP:0006191) | 1.83992430 |
71 | 11 pairs of ribs (HP:0000878) | 1.83560661 |
72 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.78162269 |
73 | Spinal muscular atrophy (HP:0007269) | 1.76922627 |
74 | Urticaria (HP:0001025) | 1.72862598 |
75 | Pseudobulbar signs (HP:0002200) | 1.72322373 |
76 | Duplicated collecting system (HP:0000081) | 1.69445439 |
77 | Slow saccadic eye movements (HP:0000514) | 1.67251547 |
78 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.65136065 |
79 | Myocardial infarction (HP:0001658) | 1.64118737 |
80 | Leukocytosis (HP:0001974) | 1.62691592 |
81 | Thin bony cortex (HP:0002753) | 1.61469202 |
82 | Verrucae (HP:0200043) | 1.59029491 |
83 | Papilloma (HP:0012740) | 1.59029491 |
84 | Basal cell carcinoma (HP:0002671) | 1.58483018 |
85 | Ulnar bowing (HP:0003031) | 1.57835228 |
86 | Chronic otitis media (HP:0000389) | 1.56285724 |
87 | Hypoplasia of the thymus (HP:0000778) | 1.55505407 |
88 | Vertebral compression fractures (HP:0002953) | 1.55362146 |
89 | Broad palm (HP:0001169) | 1.55268182 |
90 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.53812278 |
91 | Abnormality of the fingertips (HP:0001211) | 1.50565592 |
92 | Prominent nose (HP:0000448) | 1.50272430 |
93 | Long eyelashes (HP:0000527) | 1.50171782 |
94 | Striae distensae (HP:0001065) | 1.49865201 |
95 | Aneurysm (HP:0002617) | 1.47947461 |
96 | Long clavicles (HP:0000890) | 1.47944132 |
97 | Recurrent fungal infections (HP:0002841) | 1.47240194 |
98 | Hepatitis (HP:0012115) | 1.47197079 |
99 | Neoplasm of the adrenal cortex (HP:0100641) | 1.44628638 |
100 | Limb hypertonia (HP:0002509) | 1.44373287 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCR | 6.17922040 |
2 | TGFBR2 | 4.54909915 |
3 | SMG1 | 3.60905610 |
4 | EPHB1 | 3.48140666 |
5 | IRAK3 | 3.36381484 |
6 | KSR1 | 2.41709593 |
7 | MAP3K14 | 2.40830154 |
8 | TAOK2 | 2.31069431 |
9 | MAP3K10 | 2.21734109 |
10 | CDK12 | 2.17258230 |
11 | PRPF4B | 2.12706491 |
12 | FES | 2.12195893 |
13 | MAP4K1 | 2.03486731 |
14 | TRIB3 | 2.02377782 |
15 | MAP2K3 | 2.01336706 |
16 | EEF2K | 1.98980304 |
17 | TSSK6 | 1.98558363 |
18 | MARK3 | 1.89965902 |
19 | CLK1 | 1.72104986 |
20 | NME2 | 1.51571089 |
21 | CAMK1D | 1.51522807 |
22 | AKT3 | 1.49386800 |
23 | ICK | 1.44019569 |
24 | PAK4 | 1.35441802 |
25 | MAP3K3 | 1.33942445 |
26 | TAOK1 | 1.31670360 |
27 | FER | 1.26478807 |
28 | RPS6KB2 | 1.25609412 |
29 | MAP3K1 | 1.20913996 |
30 | TAF1 | 1.19226279 |
31 | CDK4 | 1.18960627 |
32 | MAP3K11 | 1.17572236 |
33 | BUB1 | 1.16702383 |
34 | STK3 | 1.15222903 |
35 | FGFR4 | 1.12365805 |
36 | KSR2 | 1.10717432 |
37 | BRAF | 1.08294062 |
38 | FGFR3 | 1.06333937 |
39 | MAP3K8 | 1.01074859 |
40 | CAMK1G | 0.94904773 |
41 | CHEK1 | 0.89686807 |
42 | PLK4 | 0.89298270 |
43 | STK4 | 0.85954042 |
44 | IRAK2 | 0.85596404 |
45 | EPHA3 | 0.85518562 |
46 | PIM1 | 0.84339452 |
47 | BRD4 | 0.80675156 |
48 | CDK7 | 0.74937086 |
49 | BTK | 0.74397149 |
50 | MAP3K13 | 0.73014728 |
51 | MAPKAPK2 | 0.72156123 |
52 | TTK | 0.71843511 |
53 | ERN1 | 0.67638270 |
54 | SIK3 | 0.67425661 |
55 | SRPK1 | 0.65686086 |
56 | MTOR | 0.64727537 |
57 | PASK | 0.64483016 |
58 | NEK2 | 0.64313318 |
59 | ATR | 0.57503200 |
60 | CDK6 | 0.56848748 |
61 | STK10 | 0.55041979 |
62 | SIK1 | 0.54468819 |
63 | HIPK2 | 0.54022549 |
64 | IRAK4 | 0.52829116 |
65 | MAPK11 | 0.51853928 |
66 | ZAP70 | 0.51786052 |
67 | MST1R | 0.50342724 |
68 | MELK | 0.48291766 |
69 | CSK | 0.47178309 |
70 | CDK9 | 0.47100459 |
71 | TBK1 | 0.46264887 |
72 | EIF2AK3 | 0.45207353 |
73 | VRK2 | 0.44221273 |
74 | PRKCI | 0.41858386 |
75 | JAK1 | 0.40622453 |
76 | TTN | 0.40066100 |
77 | RPS6KL1 | 0.39373488 |
78 | RPS6KC1 | 0.39373488 |
79 | IRAK1 | 0.39016469 |
80 | IKBKB | 0.36731531 |
81 | PTK6 | 0.35105810 |
82 | NEK6 | 0.34123059 |
83 | EPHA2 | 0.33885173 |
84 | BRSK1 | 0.33555925 |
85 | EIF2AK2 | 0.33285660 |
86 | RPS6KA6 | 0.32806851 |
87 | CDK2 | 0.32117995 |
88 | DDR2 | 0.31424051 |
89 | CHEK2 | 0.27672186 |
90 | TEC | 0.27296930 |
91 | LATS2 | 0.25218255 |
92 | LYN | 0.25175186 |
93 | JAK3 | 0.24380614 |
94 | PAK1 | 0.24141312 |
95 | STK11 | 0.24093258 |
96 | TESK2 | 0.23413995 |
97 | NEK1 | 0.22493281 |
98 | PDPK1 | 0.21124095 |
99 | CDC7 | 0.20977544 |
100 | WNK1 | 0.20593181 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.76961760 |
2 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.78961649 |
3 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.21316853 |
4 | Thyroid cancer_Homo sapiens_hsa05216 | 2.15264627 |
5 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 2.15104291 |
6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.14412182 |
7 | Measles_Homo sapiens_hsa05162 | 2.07169280 |
8 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.07035056 |
9 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.05497278 |
10 | Apoptosis_Homo sapiens_hsa04210 | 2.04618982 |
11 | Pancreatic cancer_Homo sapiens_hsa05212 | 2.01475345 |
12 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.90149467 |
13 | Hepatitis B_Homo sapiens_hsa05161 | 1.82545516 |
14 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.79858260 |
15 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.79359202 |
16 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.76029959 |
17 | Influenza A_Homo sapiens_hsa05164 | 1.74727233 |
18 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.73416143 |
19 | Bladder cancer_Homo sapiens_hsa05219 | 1.62903148 |
20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.61232249 |
21 | Colorectal cancer_Homo sapiens_hsa05210 | 1.60114113 |
22 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.50966337 |
23 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.50773547 |
24 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.50713864 |
25 | RNA transport_Homo sapiens_hsa03013 | 1.50502521 |
26 | DNA replication_Homo sapiens_hsa03030 | 1.44580891 |
27 | Mismatch repair_Homo sapiens_hsa03430 | 1.44026071 |
28 | Spliceosome_Homo sapiens_hsa03040 | 1.42120684 |
29 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.39257088 |
30 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.36872263 |
31 | Cell cycle_Homo sapiens_hsa04110 | 1.34624768 |
32 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.33950797 |
33 | Allograft rejection_Homo sapiens_hsa05330 | 1.28501084 |
34 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.25276262 |
35 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.23514583 |
36 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.23495193 |
37 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.22386204 |
38 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.22072262 |
39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.18703028 |
40 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.16177804 |
41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.13590497 |
42 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.12651184 |
43 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.09911300 |
44 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.08272346 |
45 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.07692994 |
46 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.07166563 |
47 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.06679020 |
48 | Prostate cancer_Homo sapiens_hsa05215 | 1.05653309 |
49 | Endometrial cancer_Homo sapiens_hsa05213 | 1.04356133 |
50 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.01968406 |
51 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.98557951 |
52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.97441236 |
53 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.95934972 |
54 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.95910472 |
55 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.94425580 |
56 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.93198868 |
57 | HTLV-I infection_Homo sapiens_hsa05166 | 0.83004988 |
58 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.82521109 |
59 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.82413718 |
60 | Focal adhesion_Homo sapiens_hsa04510 | 0.81351764 |
61 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.77070226 |
62 | Pathways in cancer_Homo sapiens_hsa05200 | 0.75191668 |
63 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.74554943 |
64 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.74034827 |
65 | Hepatitis C_Homo sapiens_hsa05160 | 0.71619106 |
66 | Glioma_Homo sapiens_hsa05214 | 0.71217136 |
67 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.71177683 |
68 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.70780228 |
69 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.69005102 |
70 | Shigellosis_Homo sapiens_hsa05131 | 0.67383055 |
71 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.66332715 |
72 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.64037176 |
73 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.62927871 |
74 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.62854969 |
75 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.61571516 |
76 | Adherens junction_Homo sapiens_hsa04520 | 0.59624423 |
77 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.59309284 |
78 | Legionellosis_Homo sapiens_hsa05134 | 0.58357096 |
79 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.57147028 |
80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.55721526 |
81 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.54240306 |
82 | Other glycan degradation_Homo sapiens_hsa00511 | 0.53781066 |
83 | Sulfur relay system_Homo sapiens_hsa04122 | 0.51672129 |
84 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.48955027 |
85 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.48012771 |
86 | Lysine degradation_Homo sapiens_hsa00310 | 0.47488381 |
87 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.46761311 |
88 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.43879953 |
89 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.42756899 |
90 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.42632168 |
91 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.42399293 |
92 | Prion diseases_Homo sapiens_hsa05020 | 0.41463455 |
93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39823470 |
94 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37284056 |
95 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.37109719 |
96 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.36696905 |
97 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.33502633 |
98 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.33063643 |
99 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.31267213 |
100 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.30481307 |