ASS1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)7.94584981
2urinary tract smooth muscle contraction (GO:0014848)7.85478314
3positive regulation of action potential (GO:0045760)7.46531598
4positive regulation of vascular permeability (GO:0043117)7.28254002
5bone trabecula formation (GO:0060346)5.71342103
6positive regulation of uterine smooth muscle contraction (GO:0070474)5.69076104
7negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.66907227
8drinking behavior (GO:0042756)5.19191464
9positive regulation of synaptic transmission, GABAergic (GO:0032230)5.02485962
10glial cell proliferation (GO:0014009)4.82884673
11positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)4.81731815
12aggressive behavior (GO:0002118)4.70418644
13regulation of action potential (GO:0098900)4.65043883
14regulation of uterine smooth muscle contraction (GO:0070472)4.54728415
15polyol transport (GO:0015791)4.54199184
16positive regulation of digestive system process (GO:0060456)4.52601837
17microtubule nucleation (GO:0007020)4.45176338
18olfactory bulb development (GO:0021772)4.42803729
19positive regulation of DNA-templated transcription, initiation (GO:2000144)4.37789709
20neural tube formation (GO:0001841)4.21316603
21pyrimidine nucleobase catabolic process (GO:0006208)4.15589994
22negative regulation of axon guidance (GO:1902668)4.13836925
23central nervous system projection neuron axonogenesis (GO:0021952)4.04432808
24response to auditory stimulus (GO:0010996)3.96111426
25DNA damage response, detection of DNA damage (GO:0042769)3.93757117
26DNA topological change (GO:0006265)3.88456791
27regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.84012550
28translesion synthesis (GO:0019985)3.75114083
29cerebral cortex radially oriented cell migration (GO:0021799)3.64651973
30limb bud formation (GO:0060174)3.64397803
31diterpenoid biosynthetic process (GO:0016102)3.62890458
32positive regulation of male gonad development (GO:2000020)3.60085168
33negative regulation of axon extension involved in axon guidance (GO:0048843)3.58934352
34dendritic spine morphogenesis (GO:0060997)3.58285057
35establishment of spindle localization (GO:0051293)3.56643508
36regulation of DNA-templated transcription, initiation (GO:2000142)3.45164816
37retinal ganglion cell axon guidance (GO:0031290)3.44584036
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.43052378
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.43052378
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.43052378
41maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42684276
42establishment of mitochondrion localization (GO:0051654)3.40189196
43behavioral response to pain (GO:0048266)3.38981306
44regulation of collateral sprouting (GO:0048670)3.37430469
45isoprenoid biosynthetic process (GO:0008299)3.25148388
46positive regulation of protein kinase C signaling (GO:0090037)3.24217692
47eating behavior (GO:0042755)3.24008166
48terpenoid biosynthetic process (GO:0016114)3.23301591
49hematopoietic stem cell proliferation (GO:0071425)3.22644467
50response to parathyroid hormone (GO:0071107)3.21767239
51regulation of timing of cell differentiation (GO:0048505)3.21014871
52presynaptic membrane organization (GO:0097090)3.20154204
53histone H3-K9 methylation (GO:0051567)3.18810334
54axonal fasciculation (GO:0007413)3.18264465
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.17176249
56mitochondrion transport along microtubule (GO:0047497)3.17176249
57fibroblast migration (GO:0010761)3.15628660
58heterochromatin organization (GO:0070828)3.13244460
59regulation of pigment cell differentiation (GO:0050932)3.11437079
60DNA double-strand break processing (GO:0000729)3.11256045
61embryonic retina morphogenesis in camera-type eye (GO:0060059)3.10668405
62neuronal stem cell maintenance (GO:0097150)3.05402842
63histone H3-K9 demethylation (GO:0033169)3.04235313
64negative chemotaxis (GO:0050919)3.03970771
65endosome to melanosome transport (GO:0035646)3.03495479
66endosome to pigment granule transport (GO:0043485)3.03495479
67nucleobase catabolic process (GO:0046113)3.02945017
68positive regulation of amino acid transport (GO:0051957)3.02783289
69negative regulation of microtubule depolymerization (GO:0007026)3.02477508
70hindbrain development (GO:0030902)3.00873434
71ganglion development (GO:0061548)2.97889321
72central nervous system neuron axonogenesis (GO:0021955)2.95741190
73positive regulation of renal sodium excretion (GO:0035815)2.95561744
74cerebral cortex cell migration (GO:0021795)2.94179812
75negative regulation of dendrite development (GO:2000171)2.93724840
76DNA ligation (GO:0006266)2.92230089
77microtubule anchoring (GO:0034453)2.89913846
78positive regulation of developmental pigmentation (GO:0048087)2.88231931
79peptidyl-lysine dimethylation (GO:0018027)2.87695330
80neuron recognition (GO:0008038)2.85402817
81behavioral response to ethanol (GO:0048149)2.84558076
82DNA strand renaturation (GO:0000733)2.82495855
83histone deubiquitination (GO:0016578)2.82261188
84spinal cord development (GO:0021510)2.81718272
85positive regulation of hair follicle development (GO:0051798)2.81152395
86positive regulation of hair cycle (GO:0042635)2.81152395
87cholesterol biosynthetic process (GO:0006695)2.80943973
88regulation of development, heterochronic (GO:0040034)2.80450010
89dendritic spine organization (GO:0097061)2.80009224
90dendrite development (GO:0016358)2.77443463
91righting reflex (GO:0060013)2.74373806
92regulation of stem cell maintenance (GO:2000036)2.72101239
93regulation of microtubule depolymerization (GO:0031114)2.71706863
94positive regulation of cell cycle G2/M phase transition (GO:1902751)2.71203126
95positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.71203126
96regulation of sister chromatid cohesion (GO:0007063)2.70492130
97regulation of somitogenesis (GO:0014807)2.70208304
98presynaptic membrane assembly (GO:0097105)2.69506997
99sympathetic nervous system development (GO:0048485)2.68737754
100centriole replication (GO:0007099)2.65141043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse7.29546048
2EZH2_22144423_ChIP-Seq_EOC_Human5.09125100
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.45923358
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.44678824
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.13686078
6IGF1R_20145208_ChIP-Seq_DFB_Human3.06811591
7TAF15_26573619_Chip-Seq_HEK293_Human2.93311391
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.89557755
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.85598581
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56930399
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.51422917
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51000361
13ZNF274_21170338_ChIP-Seq_K562_Hela2.38784757
14GBX2_23144817_ChIP-Seq_PC3_Human2.30598292
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.28927921
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25835759
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.22080026
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19680535
19EWS_26573619_Chip-Seq_HEK293_Human2.12604847
20FUS_26573619_Chip-Seq_HEK293_Human2.05843610
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95034340
22P300_19829295_ChIP-Seq_ESCs_Human1.87232298
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.83286784
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82642807
25SOX9_26525672_Chip-Seq_HEART_Mouse1.82365591
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79860134
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75725082
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75106790
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.71876523
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71591343
31SMAD3_21741376_ChIP-Seq_EPCs_Human1.61614124
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56009004
33IRF1_19129219_ChIP-ChIP_H3396_Human1.53540599
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50566078
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50566078
36SMAD4_21799915_ChIP-Seq_A2780_Human1.50018649
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49945950
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49735078
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46159633
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46086125
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.44545692
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43833667
43AR_25329375_ChIP-Seq_VCAP_Human1.41455465
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40484412
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40216234
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35324708
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35072347
48CBP_20019798_ChIP-Seq_JUKART_Human1.35072347
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31436676
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30691866
51STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29508808
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.27780553
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23009313
54RNF2_27304074_Chip-Seq_NSC_Mouse1.21498104
55VDR_22108803_ChIP-Seq_LS180_Human1.21225825
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.21172364
57AR_21572438_ChIP-Seq_LNCaP_Human1.20659828
58BCAT_22108803_ChIP-Seq_LS180_Human1.19953245
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19166410
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17860315
61ER_23166858_ChIP-Seq_MCF-7_Human1.17186698
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16959045
63TCF4_22108803_ChIP-Seq_LS180_Human1.16628790
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15939527
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14199758
66RUNX2_22187159_ChIP-Seq_PCA_Human1.13858524
67SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13376475
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.09995994
69TP53_22573176_ChIP-Seq_HFKS_Human1.08452642
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08255634
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07311667
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06902392
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.06800911
74STAT3_23295773_ChIP-Seq_U87_Human1.05187512
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.05100853
76TCF4_23295773_ChIP-Seq_U87_Human1.03686610
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03355543
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03326403
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03280040
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02033542
81REST_21632747_ChIP-Seq_MESCs_Mouse1.01489173
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01407894
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99257641
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98676721
85MYC_18940864_ChIP-ChIP_HL60_Human0.97270632
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94796693
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.94383249
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93406426
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92922593
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89469480
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.88855656
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88796292
93WDR5_24793694_ChIP-Seq_LNCAP_Human0.87875234
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87369930
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87108010
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86997373
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86556726
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85357113
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.85336491
100TP53_16413492_ChIP-PET_HCT116_Human0.84508620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.83346068
2MP0002736_abnormal_nociception_after3.71992363
3MP0003880_abnormal_central_pattern3.59685085
4MP0002735_abnormal_chemical_nociception3.56335699
5MP0002938_white_spotting3.24311124
6MP0000778_abnormal_nervous_system2.73272360
7MP0001968_abnormal_touch/_nociception2.63539753
8MP0008057_abnormal_DNA_replication2.62614013
9MP0003136_yellow_coat_color2.59046129
10MP0005423_abnormal_somatic_nervous2.47926944
11MP0005360_urolithiasis2.43662064
12MP0000516_abnormal_urinary_system2.13590836
13MP0005367_renal/urinary_system_phenotyp2.13590836
14MP0005171_absent_coat_pigmentation2.07208325
15MP0008932_abnormal_embryonic_tissue1.97967278
16MP0002234_abnormal_pharynx_morphology1.95299859
17MP0010094_abnormal_chromosome_stability1.92545303
18MP0003718_maternal_effect1.91138262
19MP0002233_abnormal_nose_morphology1.86122717
20MP0003890_abnormal_embryonic-extraembry1.83836637
21MP0004957_abnormal_blastocyst_morpholog1.82528366
22MP0000372_irregular_coat_pigmentation1.81412155
23MP0003252_abnormal_bile_duct1.79978645
24MP0009697_abnormal_copulation1.79411825
25MP0008995_early_reproductive_senescence1.77867355
26MP0002653_abnormal_ependyma_morphology1.72804558
27MP0002751_abnormal_autonomic_nervous1.70348940
28MP0006276_abnormal_autonomic_nervous1.68085956
29MP0003937_abnormal_limbs/digits/tail_de1.66392242
30MP0002277_abnormal_respiratory_mucosa1.63387984
31MP0000566_synostosis1.63327066
32MP0002928_abnormal_bile_duct1.57728977
33MP0003077_abnormal_cell_cycle1.56759313
34MP0001984_abnormal_olfaction1.56333091
35MP0004270_analgesia1.54916290
36MP0008058_abnormal_DNA_repair1.52594642
37MP0005499_abnormal_olfactory_system1.51478866
38MP0005394_taste/olfaction_phenotype1.51478866
39MP0004859_abnormal_synaptic_plasticity1.50714166
40MP0003385_abnormal_body_wall1.48304276
41MP0003111_abnormal_nucleus_morphology1.47172907
42MP0002734_abnormal_mechanical_nocicepti1.43337530
43MP0000647_abnormal_sebaceous_gland1.41302003
44MP0005075_abnormal_melanosome_morpholog1.40495412
45MP0008872_abnormal_physiological_respon1.39652301
46MP0003938_abnormal_ear_development1.37015509
47MP0009703_decreased_birth_body1.33362501
48MP0003861_abnormal_nervous_system1.33018807
49MP0005187_abnormal_penis_morphology1.31342755
50MP0005084_abnormal_gallbladder_morpholo1.23649637
51MP0003315_abnormal_perineum_morphology1.20469313
52MP0000538_abnormal_urinary_bladder1.19352409
53MP0002282_abnormal_trachea_morphology1.18832989
54MP0003183_abnormal_peptide_metabolism1.15856221
55MP0002067_abnormal_sensory_capabilities1.14525397
56MP0008789_abnormal_olfactory_epithelium1.14104879
57MP0009840_abnormal_foam_cell1.13778794
58MP0004811_abnormal_neuron_physiology1.11797742
59MP0006292_abnormal_olfactory_placode1.10743041
60MP0005253_abnormal_eye_physiology1.08873801
61MP0009278_abnormal_bone_marrow1.02915860
62MP0002572_abnormal_emotion/affect_behav1.02124220
63MP0002095_abnormal_skin_pigmentation1.00143287
64MP0003755_abnormal_palate_morphology0.99460586
65MP0002882_abnormal_neuron_morphology0.98936595
66MP0003787_abnormal_imprinting0.98554726
67MP0010329_abnormal_lipoprotein_level0.98163999
68MP0003646_muscle_fatigue0.96898830
69MP0002210_abnormal_sex_determination0.93940530
70MP0002752_abnormal_somatic_nervous0.93023798
71MP0002152_abnormal_brain_morphology0.92473491
72MP0006035_abnormal_mitochondrial_morpho0.92378753
73MP0001286_abnormal_eye_development0.87853682
74MP0003935_abnormal_craniofacial_develop0.86947334
75MP0003195_calcinosis0.84364754
76MP0001324_abnormal_eye_pigmentation0.84301318
77MP0005083_abnormal_biliary_tract0.84049876
78MP0006072_abnormal_retinal_apoptosis0.82262238
79MP0004924_abnormal_behavior0.81384199
80MP0005386_behavior/neurological_phenoty0.81384199
81MP0001486_abnormal_startle_reflex0.80601738
82MP0001929_abnormal_gametogenesis0.79520870
83MP0001177_atelectasis0.78690902
84MP0005391_vision/eye_phenotype0.78675668
85MP0002085_abnormal_embryonic_tissue0.76714721
86MP0003635_abnormal_synaptic_transmissio0.76512401
87MP0000432_abnormal_head_morphology0.75326357
88MP0003121_genomic_imprinting0.75294763
89MP0003948_abnormal_gas_homeostasis0.74779793
90MP0002084_abnormal_developmental_patter0.73509826
91MP0000750_abnormal_muscle_regeneration0.72725020
92MP0002557_abnormal_social/conspecific_i0.70962620
93MP0001293_anophthalmia0.70798997
94MP0001764_abnormal_homeostasis0.69994433
95MP0003698_abnormal_male_reproductive0.68286063
96MP0001145_abnormal_male_reproductive0.67898150
97MP0009053_abnormal_anal_canal0.67367199
98MP0009046_muscle_twitch0.67313522
99MP0001119_abnormal_female_reproductive0.67312187
100MP0004742_abnormal_vestibular_system0.66562396

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)5.27899681
2Tented upper lip vermilion (HP:0010804)4.74450618
3Abnormality of the labia minora (HP:0012880)4.07686141
4Oligodactyly (HP:0012165)3.92990068
5Split foot (HP:0001839)3.76316846
6Carpal bone hypoplasia (HP:0001498)3.71581204
7Tracheomalacia (HP:0002779)3.65820653
8Abnormality of the metopic suture (HP:0005556)3.40050831
9Hypoplasia of the capital femoral epiphysis (HP:0003090)3.29829356
10True hermaphroditism (HP:0010459)3.19081129
11Irregular epiphyses (HP:0010582)3.16039166
12Broad distal phalanx of finger (HP:0009836)3.08637570
13Intrahepatic cholestasis (HP:0001406)3.02343125
14Small epiphyses (HP:0010585)3.01650404
15Gait imbalance (HP:0002141)2.99145217
16Severe combined immunodeficiency (HP:0004430)2.94365917
17Abnormality of the proximal phalanges of the hand (HP:0009834)2.92714137
18B lymphocytopenia (HP:0010976)2.91843326
19Concave nail (HP:0001598)2.86891696
20Flat capital femoral epiphysis (HP:0003370)2.84494809
21Heterochromia iridis (HP:0001100)2.83701792
22Thyroiditis (HP:0100646)2.81196656
23Pancreatic cysts (HP:0001737)2.81027176
24Myelomeningocele (HP:0002475)2.80025281
25Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.79056957
26Absent epiphyses (HP:0010577)2.79056957
27Patellar aplasia (HP:0006443)2.78638294
28Vertebral arch anomaly (HP:0008438)2.69315208
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.69050919
30Impulsivity (HP:0100710)2.67642224
31Cutaneous finger syndactyly (HP:0010554)2.66416642
32Palpebral edema (HP:0100540)2.64638752
33Ependymoma (HP:0002888)2.59293629
34Prominent metopic ridge (HP:0005487)2.58770911
35Alacrima (HP:0000522)2.56004615
36Congenital primary aphakia (HP:0007707)2.51979525
37Pancreatic fibrosis (HP:0100732)2.51753970
38Abnormality of B cell number (HP:0010975)2.47002616
39Breast aplasia (HP:0100783)2.45581743
40Shawl scrotum (HP:0000049)2.43514725
41Hypoplastic labia majora (HP:0000059)2.42330984
42Aplasia/Hypoplasia of the patella (HP:0006498)2.41071558
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.39338507
44Medial flaring of the eyebrow (HP:0010747)2.38970316
45Aplasia/Hypoplasia of the breasts (HP:0010311)2.38808897
46Bifid tongue (HP:0010297)2.37758356
47Preaxial hand polydactyly (HP:0001177)2.36411278
48Hypoplastic female external genitalia (HP:0012815)2.36052318
49Renal hypoplasia (HP:0000089)2.34334867
50Thyroid-stimulating hormone excess (HP:0002925)2.33447138
51Lissencephaly (HP:0001339)2.32992789
52Decreased testicular size (HP:0008734)2.30397049
53Cystic liver disease (HP:0006706)2.28474650
54Intestinal atresia (HP:0011100)2.27509878
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.27136081
56Absent eyebrow (HP:0002223)2.26178499
57Facial hemangioma (HP:0000329)2.26177480
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.24598070
59Combined immunodeficiency (HP:0005387)2.24055461
60Labial hypoplasia (HP:0000066)2.22934323
61Abnormality of the antihelix (HP:0009738)2.20874447
62Sloping forehead (HP:0000340)2.19600135
63Anosmia (HP:0000458)2.19215006
64Abnormality of the labia majora (HP:0012881)2.18520256
65Natal tooth (HP:0000695)2.18195823
66Rhabdomyosarcoma (HP:0002859)2.16747783
67Anencephaly (HP:0002323)2.15746199
68Cutaneous syndactyly (HP:0012725)2.14564599
69Delayed epiphyseal ossification (HP:0002663)2.14003548
70Dental crowding (HP:0000678)2.12138993
71Broad alveolar ridges (HP:0000187)2.09981808
72Broad ribs (HP:0000885)2.09753702
73Hypoproteinemia (HP:0003075)2.07782310
74Absent hand (HP:0004050)2.07695918
75Hypoplasia of the thymus (HP:0000778)2.06956805
76Meckel diverticulum (HP:0002245)2.05304292
77Nephrogenic diabetes insipidus (HP:0009806)2.03980659
78Abnormality of the ileum (HP:0001549)2.03568959
79Narrow forehead (HP:0000341)2.02385851
80Decreased lacrimation (HP:0000633)2.01990603
81Astrocytoma (HP:0009592)2.00886300
82Abnormality of the astrocytes (HP:0100707)2.00886300
83Postaxial foot polydactyly (HP:0001830)2.00336065
84Genital tract atresia (HP:0001827)2.00257410
85Hepatoblastoma (HP:0002884)2.00150827
86Postaxial hand polydactyly (HP:0001162)1.96655935
87Broad foot (HP:0001769)1.94753847
88Posterior subcapsular cataract (HP:0007787)1.94147684
89Vaginal atresia (HP:0000148)1.93651459
90Metaphyseal irregularity (HP:0003025)1.92756542
91Long clavicles (HP:0000890)1.92363697
92Abnormality of chromosome stability (HP:0003220)1.91569718
93Facial cleft (HP:0002006)1.91284467
94Abnormality of the preputium (HP:0100587)1.87641345
95White forelock (HP:0002211)1.87099608
96Increased number of teeth (HP:0011069)1.86394332
97Vitreoretinal degeneration (HP:0000655)1.85653983
98Dandy-Walker malformation (HP:0001305)1.85588104
99Congenital sensorineural hearing impairment (HP:0008527)1.82970627
100Sclerocornea (HP:0000647)1.82689149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.15806903
2TNIK4.73720712
3MAPK134.32054262
4BCR2.79969420
5BMPR1B2.58217354
6BCKDK2.48586206
7TRIM282.26007727
8NEK12.22848484
9PNCK2.22391784
10WNK31.86124514
11PLK41.82081566
12DYRK31.80187553
13EPHA41.79415103
14PRKD31.79023551
15PAK61.78351387
16BRSK21.75925199
17FRK1.73582414
18TESK21.73081669
19CDK81.65485053
20MAPKAPK31.64483311
21UHMK11.56027689
22DYRK21.50348696
23BRSK11.48073845
24CASK1.46921691
25MAP3K41.44040391
26MAP2K71.43007549
27WEE11.37033192
28IRAK21.30737989
29CLK11.25382632
30TTK1.17441682
31NTRK31.15700193
32BUB11.12575451
33STK31.10414150
34PRKCG1.08355917
35NUAK11.07464696
36TGFBR11.03469937
37MKNK21.02856525
38MAPK111.02573047
39MKNK11.01923038
40MINK10.98035699
41VRK10.97200567
42CCNB10.97057846
43YES10.96122771
44NLK0.94732175
45SIK30.91922081
46VRK20.91513137
47SRPK10.91350514
48PLK10.91077841
49CDK30.90686170
50PAK30.90538541
51PBK0.85577863
52ATM0.83097200
53EPHB20.81219010
54EEF2K0.79577140
55STK40.77601746
56NTRK20.77265775
57ERBB30.76392249
58ERBB20.71549786
59ATR0.71329770
60PAK20.71078982
61CSNK1G20.68299785
62CDC70.67661523
63NEK20.67369657
64SGK4940.65928362
65SGK2230.65928362
66PKN10.65128868
67PLK30.64169816
68MAP3K70.60103181
69SGK20.58743293
70PRKCZ0.55475124
71PRKG10.54927450
72CDK190.54904288
73BRD40.53854725
74MAPK80.49402186
75MAP2K40.48607008
76FGFR20.45845782
77CSNK1G10.45181482
78CDK20.44976363
79CDK10.43026258
80CHEK20.41969805
81CSNK1A1L0.39435397
82AKT30.39431413
83PRKDC0.39261509
84CDK180.38943767
85RPS6KA40.38460543
86CDK40.38031888
87CSNK1D0.36906676
88PHKG10.36049560
89PHKG20.36049560
90MAPKAPK50.35891457
91MAPK150.35743409
92CHEK10.35600955
93MAPK120.33617254
94TAOK10.33422165
95CDK150.33383591
96RPS6KA10.33000626
97CSNK1G30.32796429
98CDK11A0.31500382
99PRKACB0.29844993
100GSK3B0.29720202

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.27410100
2Homologous recombination_Homo sapiens_hsa034403.96600084
3Steroid biosynthesis_Homo sapiens_hsa001003.55189030
4Base excision repair_Homo sapiens_hsa034102.83360939
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72744783
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.52796616
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.36701466
8Fanconi anemia pathway_Homo sapiens_hsa034602.32850796
9Lysine degradation_Homo sapiens_hsa003102.27960769
10Hedgehog signaling pathway_Homo sapiens_hsa043402.15973350
11Mismatch repair_Homo sapiens_hsa034302.13119898
12Propanoate metabolism_Homo sapiens_hsa006402.07668636
13Butanoate metabolism_Homo sapiens_hsa006501.95697568
14Nicotine addiction_Homo sapiens_hsa050331.95222306
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94099685
16Pyruvate metabolism_Homo sapiens_hsa006201.92754090
17Fatty acid elongation_Homo sapiens_hsa000621.86459997
18Nucleotide excision repair_Homo sapiens_hsa034201.75468925
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71318395
20Fatty acid metabolism_Homo sapiens_hsa012121.70046302
21Basal cell carcinoma_Homo sapiens_hsa052171.55373266
22DNA replication_Homo sapiens_hsa030301.45236164
23Protein export_Homo sapiens_hsa030601.42996261
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42900580
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41748510
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39029228
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30905359
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29308832
29Axon guidance_Homo sapiens_hsa043601.29201701
30Taste transduction_Homo sapiens_hsa047421.26618905
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25936694
32Circadian rhythm_Homo sapiens_hsa047101.25469012
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23878205
34Hippo signaling pathway_Homo sapiens_hsa043901.23516944
35Fatty acid degradation_Homo sapiens_hsa000711.18548458
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15422805
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12823263
38Cell cycle_Homo sapiens_hsa041101.12245335
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07299637
40Chemical carcinogenesis_Homo sapiens_hsa052041.05500505
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04736433
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04455679
43Retinol metabolism_Homo sapiens_hsa008301.04108048
44Basal transcription factors_Homo sapiens_hsa030221.03405010
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01833660
46Peroxisome_Homo sapiens_hsa041460.99870542
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98486871
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.95226369
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94764729
50Linoleic acid metabolism_Homo sapiens_hsa005910.94157783
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93869233
52Regulation of autophagy_Homo sapiens_hsa041400.89429854
53Wnt signaling pathway_Homo sapiens_hsa043100.87835359
54RNA polymerase_Homo sapiens_hsa030200.84681317
55Spliceosome_Homo sapiens_hsa030400.83873728
56Adherens junction_Homo sapiens_hsa045200.77290162
57Glutamatergic synapse_Homo sapiens_hsa047240.73712603
58RNA degradation_Homo sapiens_hsa030180.70842313
59Fatty acid biosynthesis_Homo sapiens_hsa000610.70642452
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66330010
61Primary immunodeficiency_Homo sapiens_hsa053400.65996908
62Glycerolipid metabolism_Homo sapiens_hsa005610.65466875
63Tryptophan metabolism_Homo sapiens_hsa003800.63453066
64Fat digestion and absorption_Homo sapiens_hsa049750.61980952
65beta-Alanine metabolism_Homo sapiens_hsa004100.61069858
66Sphingolipid metabolism_Homo sapiens_hsa006000.60476136
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59775519
68Vitamin digestion and absorption_Homo sapiens_hsa049770.59186083
69Complement and coagulation cascades_Homo sapiens_hsa046100.59010769
70Type II diabetes mellitus_Homo sapiens_hsa049300.57252447
71ABC transporters_Homo sapiens_hsa020100.55594476
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52771758
73Pyrimidine metabolism_Homo sapiens_hsa002400.52636821
74Metabolic pathways_Homo sapiens_hsa011000.52478078
75TGF-beta signaling pathway_Homo sapiens_hsa043500.51738898
76Sulfur relay system_Homo sapiens_hsa041220.51138532
77Calcium signaling pathway_Homo sapiens_hsa040200.50415980
78Carbon metabolism_Homo sapiens_hsa012000.49813700
79Biosynthesis of amino acids_Homo sapiens_hsa012300.46697568
80Oocyte meiosis_Homo sapiens_hsa041140.46576744
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41444284
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40072342
83Purine metabolism_Homo sapiens_hsa002300.39870288
84Huntingtons disease_Homo sapiens_hsa050160.39479722
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.38898102
86Olfactory transduction_Homo sapiens_hsa047400.37637538
87Cocaine addiction_Homo sapiens_hsa050300.36511220
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35903344
89Proteasome_Homo sapiens_hsa030500.35000793
90Circadian entrainment_Homo sapiens_hsa047130.33166714
91Glutathione metabolism_Homo sapiens_hsa004800.31783205
92RNA transport_Homo sapiens_hsa030130.31299846
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.29225471
94Ether lipid metabolism_Homo sapiens_hsa005650.27080045
95Parkinsons disease_Homo sapiens_hsa050120.26284385
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25450277
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.24503617
98Caffeine metabolism_Homo sapiens_hsa002320.24243656
99mRNA surveillance pathway_Homo sapiens_hsa030150.23171500
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22946507

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