ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.70262174
2	lipopolysaccharide biosynthetic process (GO:0009103)	9.40950568
3	protein-chromophore linkage (GO:0018298)	9.07827137
4	DNA methylation involved in gamete generation (GO:0043046)	8.87703011
5	lipopolysaccharide metabolic process (GO:0008653)	8.25823687
6	regulation of meiosis I (GO:0060631)	8.21273195
7	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.95341601
8	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.77515946
9	regulation of protein glycosylation (GO:0060049)	7.67556575
10	sulfate transmembrane transport (GO:1902358)	7.47418408
11	paraxial mesoderm development (GO:0048339)	7.42007588
12	regulation of pigment cell differentiation (GO:0050932)	7.38979352
13	positive regulation of developmental pigmentation (GO:0048087)	7.26283663
14	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	7.14149657
15	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.89204780
16	sulfate transport (GO:0008272)	6.36956773
17	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.19583052
18	L-phenylalanine catabolic process (GO:0006559)	6.19583052
19	piRNA metabolic process (GO:0034587)	6.17219430
20	negative regulation of glycoprotein metabolic process (GO:1903019)	5.99324401
21	SMAD protein complex assembly (GO:0007183)	5.83972709
22	notochord development (GO:0030903)	5.76172235
23	heme transport (GO:0015886)	5.43534743
24	tyrosine metabolic process (GO:0006570)	5.42578872
25	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.38941753
26	L-phenylalanine metabolic process (GO:0006558)	5.38941753
27	ribonucleoprotein complex disassembly (GO:0032988)	5.18617932
28	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.78134371
29	nodal signaling pathway (GO:0038092)	4.69347070
30	positive regulation of meiosis (GO:0045836)	4.67447340
31	negative regulation of stem cell proliferation (GO:2000647)	4.64874684
32	regulation of transforming growth factor beta2 production (GO:0032909)	4.61416701
33	centriole replication (GO:0007099)	4.50280186
34	meiotic chromosome segregation (GO:0045132)	4.47092543
35	serotonin receptor signaling pathway (GO:0007210)	4.41535964
36	protein retention in ER lumen (GO:0006621)	4.40997944
37	positive regulation of meiotic cell cycle (GO:0051446)	4.33967756
38	regulation of interleukin-5 production (GO:0032674)	4.33594826
39	regulation of odontogenesis (GO:0042481)	4.32875413
40	response to mercury ion (GO:0046689)	4.29420403
41	germinal center formation (GO:0002467)	4.27946033
42	vitamin transmembrane transport (GO:0035461)	4.10988575
43	glycerol metabolic process (GO:0006071)	4.10096007
44	organelle disassembly (GO:1903008)	4.06375451
45	cellular response to gamma radiation (GO:0071480)	4.02951537
46	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.00405538
47	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.99979045
48	iron coordination entity transport (GO:1901678)	3.91821093
49	DNA damage induced protein phosphorylation (GO:0006975)	3.90768550
50	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.82299486
51	response to epinephrine (GO:0071871)	3.81013267
52	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.78251578
53	flavonoid metabolic process (GO:0009812)	3.77461482
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.76666981
55	tachykinin receptor signaling pathway (GO:0007217)	3.75389502
56	heart valve formation (GO:0003188)	3.69761535
57	aromatic amino acid family catabolic process (GO:0009074)	3.67420960
58	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.67013667
59	pantothenate metabolic process (GO:0015939)	3.66432554
60	sulfur compound transport (GO:0072348)	3.65664039
61	embryonic process involved in female pregnancy (GO:0060136)	3.65477744
62	negative regulation of neural precursor cell proliferation (GO:2000178)	3.64098808
63	toxin metabolic process (GO:0009404)	3.64083809
64	alditol metabolic process (GO:0019400)	3.63835596
65	rhodopsin mediated signaling pathway (GO:0016056)	3.62989395
66	regulation of developmental pigmentation (GO:0048070)	3.61987743
67	negative regulation of cell-matrix adhesion (GO:0001953)	3.59313968
68	inflammatory response to antigenic stimulus (GO:0002437)	3.40116309
69	sympathetic nervous system development (GO:0048485)	3.38395261
70	aspartate family amino acid catabolic process (GO:0009068)	3.34138202
71	uterus development (GO:0060065)	3.30276897
72	lysine metabolic process (GO:0006553)	3.26660576
73	lysine catabolic process (GO:0006554)	3.26660576
74	regulation of keratinocyte proliferation (GO:0010837)	3.26083889
75	urate metabolic process (GO:0046415)	3.20639154
76	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.19002460
77	organ induction (GO:0001759)	3.18866666
78	regulation of hair follicle development (GO:0051797)	3.17158518
79	regulation of translational termination (GO:0006449)	3.14360690
80	aromatic amino acid family metabolic process (GO:0009072)	3.12331487
81	polyol biosynthetic process (GO:0046173)	3.07223203
82	somite rostral/caudal axis specification (GO:0032525)	3.06036297
83	biotin metabolic process (GO:0006768)	3.05729720
84	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	3.02021755
85	centriole assembly (GO:0098534)	3.01208740
86	DNA methylation (GO:0006306)	2.98883727
87	DNA alkylation (GO:0006305)	2.98883727
88	negative regulation of BMP signaling pathway (GO:0030514)	2.92085276
89	regulation of SMAD protein import into nucleus (GO:0060390)	2.91578190
90	membrane lipid biosynthetic process (GO:0046467)	2.91303616
91	sphingolipid biosynthetic process (GO:0030148)	2.89019926
92	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.87709856
93	cofactor transport (GO:0051181)	2.85587777
94	regulation of metanephros development (GO:0072215)	2.85539973
95	positive regulation of fatty acid oxidation (GO:0046321)	2.84662589
96	negative regulation of carbohydrate metabolic process (GO:0045912)	2.76890786
97	positive regulation of vascular permeability (GO:0043117)	2.76153332
98	sphingosine metabolic process (GO:0006670)	17.7680517
99	diol metabolic process (GO:0034311)	16.0814388
100	sphingoid metabolic process (GO:0046519)	14.2968125

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	5.51357342
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.25483257
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.72830088
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.70783887
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.49606225
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.12643467
7	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.82421446
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.63716773
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.24266277
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16304355
11	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	2.15517971
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.14781942
13	EGR1_19032775_ChIP-ChIP_M12_Human	2.13200171
14	P300_19829295_ChIP-Seq_ESCs_Human	2.09780848
15	NANOG_19829295_ChIP-Seq_ESCs_Human	1.84610970
16	SOX2_19829295_ChIP-Seq_ESCs_Human	1.84610970
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.84053976
18	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.83894561
19	HOXB7_26014856_ChIP-Seq_BT474_Human	1.81803108
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.81472814
21	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.78399205
22	STAT1_20625510_ChIP-Seq_HELA_Human	1.77598183
23	ZNF274_21170338_ChIP-Seq_K562_Hela	1.74747878
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73882715
25	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.71066632
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66726215
27	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64768356
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64768356
29	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.53627808
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53389861
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.48850972
32	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48474215
33	TCF4_23295773_ChIP-Seq_U87_Human	1.47722813
34	OCT4_20526341_ChIP-Seq_ESCs_Human	1.45834039
35	STAT3_23295773_ChIP-Seq_U87_Human	1.41744871
36	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.40309542
37	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39539743
38	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.35415795
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35324258
40	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33591787
41	AR_25329375_ChIP-Seq_VCAP_Human	1.31708314
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31132996
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30276434
44	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.29236021
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27067972
46	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.26933642
47	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.25023195
48	AR_19668381_ChIP-Seq_PC3_Human	1.24708944
49	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.24341597
50	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.23225347
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.23140970
52	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22539103
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21934555
54	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.21821015
55	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.21603356
56	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.20135304
57	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18119131
58	NCOR_22424771_ChIP-Seq_293T_Human	1.17636341
59	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.16908212
60	VDR_22108803_ChIP-Seq_LS180_Human	1.16806477
61	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.16340318
62	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.16212199
63	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.15465741
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13708422
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12758683
66	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.12086025
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12001443
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09885785
69	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08651791
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08056415
71	CEBPB_22108803_ChIP-Seq_LS180_Human	1.07564004
72	STAT1_17558387_ChIP-Seq_HELA_Human	1.06569771
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.05557457
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.05557457
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05086975
76	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04431046
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.03899173
78	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03464907
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01691476
80	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01635171
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00043064
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99875083
83	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.99392009
84	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.99010621
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98898768
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98566095
87	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98312181
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98146941
89	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.96942946
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.96538637
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96234675
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.96045963
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.95883441
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94659528
95	TP53_16413492_ChIP-PET_HCT116_Human	0.94349096
96	SPI1_20517297_ChIP-Seq_HL60_Human	0.93787626
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93782741
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.91814068
99	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.91408403
100	TP63_23658742_ChIP-Seq_EP156T_Human	0.91069375

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.54923141
2	MP0003136_yellow_coat_color	8.04404652
3	MP0005171_absent_coat_pigmentation	7.61680853
4	MP0002653_abnormal_ependyma_morphology	5.98616907
5	MP0003045_fibrosis	4.65214179
6	MP0003890_abnormal_embryonic-extraembry	4.54705024
7	MP0003646_muscle_fatigue	4.02853643
8	MP0003879_abnormal_hair_cell	3.43262940
9	MP0000569_abnormal_digit_pigmentation	3.09086397
10	MP0004381_abnormal_hair_follicle	3.07465293
11	MP0002138_abnormal_hepatobiliary_system	2.43755154
12	MP0005670_abnormal_white_adipose	2.27256303
13	MP0003705_abnormal_hypodermis_morpholog	2.24427435
14	MP0005085_abnormal_gallbladder_physiolo	2.17854572
15	MP0000749_muscle_degeneration	2.12790498
16	MP0005075_abnormal_melanosome_morpholog	2.04438531
17	MP0002168_other_aberrant_phenotype	1.95537773
18	MP0004147_increased_porphyrin_level	1.90812215
19	MP0002938_white_spotting	1.85371550
20	MP0010352_gastrointestinal_tract_polyps	1.66019865
21	MP0005365_abnormal_bile_salt	1.49486658
22	MP0003195_calcinosis	1.38832021
23	MP0002095_abnormal_skin_pigmentation	1.30616962
24	MP0002075_abnormal_coat/hair_pigmentati	1.27907962
25	MP0004233_abnormal_muscle_weight	1.26482054
26	MP0005395_other_phenotype	1.11635530
27	MP0002160_abnormal_reproductive_system	1.10702411
28	MP0003137_abnormal_impulse_conducting	1.04004628
29	MP0005330_cardiomyopathy	1.01334099
30	MP0006054_spinal_hemorrhage	0.99721632
31	MP0005174_abnormal_tail_pigmentation	0.99238018
32	MP0002269_muscular_atrophy	0.94713444
33	MP0001186_pigmentation_phenotype	0.91166308
34	MP0002735_abnormal_chemical_nociception	0.84840359
35	MP0001501_abnormal_sleep_pattern	0.83312629
36	MP0003300_gastrointestinal_ulcer	0.80919248
37	MP0004043_abnormal_pH_regulation	0.79094836
38	MP0002254_reproductive_system_inflammat	0.77537141
39	MP0003252_abnormal_bile_duct	0.74586486
40	MP0000427_abnormal_hair_cycle	0.74456436
41	MP0000015_abnormal_ear_pigmentation	0.67709510
42	MP0005319_abnormal_enzyme/_coenzyme	0.66546476
43	MP0001324_abnormal_eye_pigmentation	0.64477410
44	MP0001984_abnormal_olfaction	0.63026578
45	MP0000534_abnormal_ureter_morphology	0.62402076
46	MP0005377_hearing/vestibular/ear_phenot	0.60209339
47	MP0003878_abnormal_ear_physiology	0.60209339
48	MP0008770_decreased_survivor_rate	0.59283680
49	MP0005076_abnormal_cell_differentiation	0.58328974
50	MP0002332_abnormal_exercise_endurance	0.56755406
51	MP0002876_abnormal_thyroid_physiology	0.55102529
52	MP0008569_lethality_at_weaning	0.54636710
53	MP0002971_abnormal_brown_adipose	0.54210501
54	MP0001661_extended_life_span	0.53773382
55	MP0001486_abnormal_startle_reflex	0.53096766
56	MP0002272_abnormal_nervous_system	0.52993687
57	MP0003950_abnormal_plasma_membrane	0.51692253
58	MP0005389_reproductive_system_phenotype	0.47246388
59	MP0009764_decreased_sensitivity_to	0.46181028
60	MP0002396_abnormal_hematopoietic_system	0.44431117
61	MP0001970_abnormal_pain_threshold	0.41463103
62	MP0002277_abnormal_respiratory_mucosa	0.40768166
63	MP0009115_abnormal_fat_cell	0.39798623
64	MP0005410_abnormal_fertilization	0.37985342
65	MP0004130_abnormal_muscle_cell	0.37959027
66	MP0009745_abnormal_behavioral_response	0.37250170
67	MP0002928_abnormal_bile_duct	0.36853864
68	MP0008874_decreased_physiological_sensi	0.34972639
69	MP0003937_abnormal_limbs/digits/tail_de	0.34846530
70	MP0010307_abnormal_tumor_latency	0.34060476
71	MP0009046_muscle_twitch	0.32006337
72	MP0002229_neurodegeneration	0.31945841
73	MP0000377_abnormal_hair_follicle	0.30629286
74	MP0003959_abnormal_lean_body	0.30604024
75	MP0002064_seizures	0.30451361
76	MP0002751_abnormal_autonomic_nervous	0.30287735
77	MP0005551_abnormal_eye_electrophysiolog	0.30084154
78	MP0002733_abnormal_thermal_nociception	0.29231299
79	MP0002106_abnormal_muscle_physiology	0.27895642
80	MP0004142_abnormal_muscle_tone	0.27884737
81	MP0003632_abnormal_nervous_system	0.27740650
82	MP0008875_abnormal_xenobiotic_pharmacok	0.26630583
83	MP0002572_abnormal_emotion/affect_behav	0.25913535
84	MP0008872_abnormal_physiological_respon	0.25345825
85	MP0005646_abnormal_pituitary_gland	0.25120372
86	MP0005266_abnormal_metabolism	0.24596279
87	MP0000026_abnormal_inner_ear	0.23305239
88	MP0003763_abnormal_thymus_physiology	0.23197768
89	MP0004484_altered_response_of	0.23126209
90	MP0000470_abnormal_stomach_morphology	0.23112997
91	MP0003385_abnormal_body_wall	0.22179421
92	MP0005448_abnormal_energy_balance	0.21011021
93	MP0003183_abnormal_peptide_metabolism	0.20948714
94	MP0005451_abnormal_body_composition	0.20850024
95	MP0000367_abnormal_coat/_hair	0.20707366
96	MP0001800_abnormal_humoral_immune	0.19936058
97	MP0001790_abnormal_immune_system	0.19617396
98	MP0005387_immune_system_phenotype	0.19617396
99	MP0005535_abnormal_body_temperature	0.18960754
100	MP0008932_abnormal_embryonic_tissue	0.18140040

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	8.03115356
2	Acanthocytosis (HP:0001927)	7.87689945
3	Parakeratosis (HP:0001036)	7.44354976
4	Aplastic anemia (HP:0001915)	6.54937442
5	Dialeptic seizures (HP:0011146)	5.04040045
6	Proximal amyotrophy (HP:0007126)	4.94127051
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.77741905
8	Rectal prolapse (HP:0002035)	4.63146085
9	Congenital ichthyosiform erythroderma (HP:0007431)	4.57498636
10	Colon cancer (HP:0003003)	4.44970331
11	Vertebral arch anomaly (HP:0008438)	4.41803085
12	Spontaneous hematomas (HP:0007420)	4.40176354
13	Hematochezia (HP:0002573)	4.35352234
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.12594214
15	Scapular winging (HP:0003691)	4.09462765
16	Focal seizures (HP:0007359)	3.99199388
17	Difficulty walking (HP:0002355)	3.95434185
18	Erythroderma (HP:0001019)	3.84909213
19	Ulnar bowing (HP:0003031)	3.55134372
20	Pancreatic cysts (HP:0001737)	3.47520658
21	Esophageal varix (HP:0002040)	3.42139236
22	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.41194702
23	Conjunctival telangiectasia (HP:0000524)	3.40623742
24	Poikilocytosis (HP:0004447)	3.38642590
25	Overlapping toe (HP:0001845)	3.35795948
26	Facial shape deformation (HP:0011334)	3.35622062
27	Potter facies (HP:0002009)	3.35622062
28	Bilateral sensorineural hearing impairment (HP:0008619)	3.35353617
29	Ulnar claw (HP:0001178)	3.32303148
30	Radial bowing (HP:0002986)	3.18524347
31	Enlarged kidneys (HP:0000105)	2.94234243
32	Broad ribs (HP:0000885)	2.91372129
33	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.72478596
34	Petechiae (HP:0000967)	2.72217371
35	IgM deficiency (HP:0002850)	2.72030780
36	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.69496842
37	Synostosis of carpal bones (HP:0005048)	2.69098734
38	Pendular nystagmus (HP:0012043)	2.67596557
39	Abnormality of the vocal cords (HP:0008777)	2.66576103
40	Abnormality of the renal cortex (HP:0011035)	2.63620598
41	Hypoplastic iliac wings (HP:0002866)	2.49214558
42	Gangrene (HP:0100758)	2.48627448
43	Portal hypertension (HP:0001409)	2.46857502
44	Autoimmune hemolytic anemia (HP:0001890)	2.43320781
45	Peripheral hypomyelination (HP:0007182)	2.42980064
46	Abnormality of the shoulder girdle musculature (HP:0001435)	2.42557923
47	Severe visual impairment (HP:0001141)	2.35495719
48	Progressive inability to walk (HP:0002505)	2.35378602
49	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.29920730
50	Tarsal synostosis (HP:0008368)	2.29694791
51	Abnormality of the hepatic vasculature (HP:0006707)	2.26617498
52	Hypokalemia (HP:0002900)	2.21833790
53	Decreased circulating renin level (HP:0003351)	2.21768535
54	Type I transferrin isoform profile (HP:0003642)	2.21149263
55	Lack of skin elasticity (HP:0100679)	2.19297852
56	Cerebellar dysplasia (HP:0007033)	2.18727190
57	Chronic diarrhea (HP:0002028)	2.17994169
58	Abnormality of the renal medulla (HP:0100957)	2.17526083
59	Dehydration (HP:0001944)	2.17145340
60	Albinism (HP:0001022)	2.11889797
61	Thickened calvaria (HP:0002684)	2.11477131
62	Abnormality of macular pigmentation (HP:0008002)	2.08635917
63	Synostosis involving bones of the lower limbs (HP:0009138)	2.08407192
64	Synostosis involving bones of the feet (HP:0009140)	2.08407192
65	Tubulointerstitial fibrosis (HP:0005576)	2.07526210
66	Hypoalbuminemia (HP:0003073)	2.06889549
67	Abnormal albumin level (HP:0012116)	2.06889549
68	Opisthotonus (HP:0002179)	2.06597739
69	Bowing of the arm (HP:0006488)	2.04810085
70	Bowed forearm bones (HP:0003956)	2.04810085
71	Colitis (HP:0002583)	2.04086564
72	Visceral angiomatosis (HP:0100761)	2.04049615
73	Amelogenesis imperfecta (HP:0000705)	10.4765416
74	Focal motor seizures (HP:0011153)	10.0157237
75	Gastrointestinal stroma tumor (HP:0100723)	1.99666998
76	Abnormality of potassium homeostasis (HP:0011042)	1.98807891
77	Recurrent sinusitis (HP:0011108)	1.97959885
78	Hemangiomatosis (HP:0007461)	1.95816297
79	Chromsome breakage (HP:0040012)	1.89558577
80	Purpura (HP:0000979)	1.88033472
81	Neoplasm of the small intestine (HP:0100833)	1.86862549
82	Palmoplantar keratoderma (HP:0000982)	1.85699786
83	Right ventricular cardiomyopathy (HP:0011663)	1.84826366
84	Aortic valve stenosis (HP:0001650)	1.84760446
85	Tubular atrophy (HP:0000092)	1.82993330
86	Retinitis pigmentosa (HP:0000510)	1.79408607
87	Cystic liver disease (HP:0006706)	1.75453111
88	Pancytopenia (HP:0001876)	1.75390457
89	Carpal synostosis (HP:0009702)	1.73581261
90	Nephronophthisis (HP:0000090)	1.71482212
91	Neoplasm of the colon (HP:0100273)	1.71299150
92	Asymmetric septal hypertrophy (HP:0001670)	1.69075023
93	Stomach cancer (HP:0012126)	1.68960993
94	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.68939839
95	IgA deficiency (HP:0002720)	1.67837472
96	Ulnar deviation of finger (HP:0009465)	1.67180939
97	Inability to walk (HP:0002540)	1.66739736
98	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.64941824
99	Type II lissencephaly (HP:0007260)	1.62855299
100	Abnormality of the wing of the ilium (HP:0011867)	1.62794640

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.39723776
2	LATS2	6.96220985
3	PRKD3	3.06870015
4	STK38	2.83574465
5	ZAK	2.73302253
6	ACVR1B	2.51481921
7	NLK	2.44469745
8	MAP2K2	2.19030102
9	STK3	2.15451990
10	FRK	2.09935566
11	LATS1	11.0244505
12	MELK	1.94942338
13	BMPR1B	1.56843201
14	MAP3K2	1.19928690
15	KSR2	1.10966033
16	NEK2	1.08303888
17	IRAK3	1.07469072
18	PDPK1	1.01884180
19	PIK3CG	0.98996713
20	TAF1	0.98920834
21	PRKAA2	0.97368258
22	GRK7	0.85905489
23	EIF2AK3	0.79561887
24	TGFBR1	0.77657307
25	CSNK1A1L	0.73597518
26	PINK1	0.73225640
27	TGFBR2	0.62466644
28	PRKD1	0.61802987
29	MOS	0.59757019
30	DAPK2	0.54135451
31	NEK9	0.53938167
32	ADRBK1	0.51038780
33	TTK	0.49616142
34	ADRBK2	0.44188959
35	NME1	0.42636484
36	GRK5	0.41113975
37	MAP2K1	0.38516493
38	TNK2	0.33841842
39	STK10	0.32766770
40	STK11	0.32666736
41	PIM1	0.30853877
42	WNK4	0.22980286
43	TAOK3	0.22652198
44	PLK1	0.18681704
45	PRKCI	0.18454413
46	CHEK2	0.17254596
47	CSNK1D	0.17200954
48	MAPK3	0.11641378
49	AKT2	0.10904493
50	ABL1	0.09766703
51	CDK3	0.09330556
52	MAP3K1	0.09206203
53	OXSR1	0.07054515
54	FER	0.06791405
55	TXK	0.06139516
56	ITK	0.05870925
57	EIF2AK2	0.05613934
58	JAK2	0.05382130
59	RET	0.03938273
60	MAPK1	0.03441312
61	STK39	0.02419934
62	PRKACA	0.02389929
63	TEC	0.02295180
64	NEK1	0.02204988
65	CAMK2B	0.02155612
66	MAP3K8	0.01850339
67	PRKCE	0.01223987
68	PRKCZ	-0.1114426
69	INSRR	-0.1101141
70	BTK	-0.1084087
71	ATM	-0.1079317
72	CDK2	-0.1059743
73	WNK3	-0.0950747
74	PRKCB	-0.0896075
75	PLK2	-0.0857081
76	CDK4	-0.0761851
77	GRK1	-0.0734020
78	PDGFRA	-0.0665446
79	PLK3	-0.0649367
80	PAK1	-0.0642395
81	GSK3B	-0.0638884
82	DAPK1	-0.0630834
83	NTRK3	-0.0621772
84	PRKCG	-0.0614420
85	AKT1	-0.0593882
86	ATR	-0.0571558
87	CSNK1A1	-0.0450951
88	PRKCH	-0.0450908
89	PTK2B	-0.0411621
90	CDK5	-0.0398012
91	PRKG2	-0.0343713
92	PDK1	-0.0314743
93	MAPK7	-0.0297536
94	STK24	-0.0268553
95	NEK6	-0.0184744
96	MAPK8	-0.0179321
97	IRAK4	-0.0178654
98	PRKACB	-0.0134710
99	MAP3K7	-0.0070444
100	CAMK2A	-0.0045463

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	9.22800377
2	Phototransduction_Homo sapiens_hsa04744	4.46093562
3	Sphingolipid metabolism_Homo sapiens_hsa00600	4.09030253
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.93728113
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.27730250
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.84948036
7	Nicotine addiction_Homo sapiens_hsa05033	2.72321162
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.28811616
9	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.16398532
10	Taste transduction_Homo sapiens_hsa04742	2.06222059
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.96704461
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.93619254
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.76594598
14	Morphine addiction_Homo sapiens_hsa05032	1.69438705
15	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.55972309
16	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.52957245
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.44606631
18	Histidine metabolism_Homo sapiens_hsa00340	1.32990903
19	GABAergic synapse_Homo sapiens_hsa04727	1.27541133
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.16671582
21	One carbon pool by folate_Homo sapiens_hsa00670	1.13749993
22	Viral myocarditis_Homo sapiens_hsa05416	1.09968308
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.09357701
24	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.06190716
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06079506
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04823886
27	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.02539832
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01138654
29	VEGF signaling pathway_Homo sapiens_hsa04370	0.99486506
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98494359
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97240232
32	Tyrosine metabolism_Homo sapiens_hsa00350	0.96323788
33	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.84274214
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82048047
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77192856
36	ABC transporters_Homo sapiens_hsa02010	0.76529082
37	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.72421638
38	Bile secretion_Homo sapiens_hsa04976	0.68433373
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.67957378
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67694951
41	Glutamatergic synapse_Homo sapiens_hsa04724	0.67591773
42	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63575804
43	Adherens junction_Homo sapiens_hsa04520	0.63289089
44	Serotonergic synapse_Homo sapiens_hsa04726	0.63008203
45	Butanoate metabolism_Homo sapiens_hsa00650	0.62157210
46	ECM-receptor interaction_Homo sapiens_hsa04512	0.62091920
47	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.58408244
48	Basal transcription factors_Homo sapiens_hsa03022	0.57132881
49	Colorectal cancer_Homo sapiens_hsa05210	0.56920247
50	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56912409
51	Thyroid cancer_Homo sapiens_hsa05216	0.55188050
52	Pyruvate metabolism_Homo sapiens_hsa00620	0.51144442
53	cAMP signaling pathway_Homo sapiens_hsa04024	0.50832766
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50823786
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49176311
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48489645
57	Fatty acid degradation_Homo sapiens_hsa00071	0.47558991
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.45576462
59	Lysine degradation_Homo sapiens_hsa00310	0.45149653
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44371737
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42592525
62	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39764521
63	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.37818146
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35241084
65	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.33092551
66	Pancreatic cancer_Homo sapiens_hsa05212	0.32989091
67	Tuberculosis_Homo sapiens_hsa05152	0.31726138
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31323289
69	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.29502169
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.28224256
71	Olfactory transduction_Homo sapiens_hsa04740	0.27971544
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27379388
73	Folate biosynthesis_Homo sapiens_hsa00790	0.26804771
74	Salivary secretion_Homo sapiens_hsa04970	0.26612200
75	Homologous recombination_Homo sapiens_hsa03440	0.24404217
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24173662
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.23828268
78	African trypanosomiasis_Homo sapiens_hsa05143	0.23551103
79	Cell cycle_Homo sapiens_hsa04110	0.21862426
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.21643238
81	Melanogenesis_Homo sapiens_hsa04916	0.18983279
82	Retinol metabolism_Homo sapiens_hsa00830	0.18353341
83	Oocyte meiosis_Homo sapiens_hsa04114	0.17935495
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.15955708
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.15858256
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.15360154
87	Sulfur relay system_Homo sapiens_hsa04122	0.15340480
88	Estrogen signaling pathway_Homo sapiens_hsa04915	0.14530607
89	Circadian entrainment_Homo sapiens_hsa04713	0.14048122
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.13864607
91	Metabolic pathways_Homo sapiens_hsa01100	0.13701986
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.12321866
93	Gastric acid secretion_Homo sapiens_hsa04971	0.12301338
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.11328477
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.11250668
96	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.11071482
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.10761746
98	Gap junction_Homo sapiens_hsa04540	0.10285889
99	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.09059339
100	Insulin secretion_Homo sapiens_hsa04911	0.08708108

ASS1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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