ASTE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.64416410
2proteasome assembly (GO:0043248)4.58762008
3protein polyglutamylation (GO:0018095)4.48408618
4axoneme assembly (GO:0035082)4.37141961
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.09297067
6photoreceptor cell maintenance (GO:0045494)4.01120146
7axonemal dynein complex assembly (GO:0070286)3.93508663
8presynaptic membrane organization (GO:0097090)3.88534360
9epithelial cilium movement (GO:0003351)3.87531676
10DNA deamination (GO:0045006)3.87360171
11RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.86357309
12inner ear receptor cell differentiation (GO:0060113)3.81918823
13termination of RNA polymerase III transcription (GO:0006386)3.81053641
14transcription elongation from RNA polymerase III promoter (GO:0006385)3.81053641
15retinal cone cell development (GO:0046549)3.68033211
16ribosomal small subunit assembly (GO:0000028)3.61048091
17multicellular organism reproduction (GO:0032504)3.56701012
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.50625950
19respiratory chain complex IV assembly (GO:0008535)3.49279596
20cellular ketone body metabolic process (GO:0046950)3.48681325
21regulation of meiosis I (GO:0060631)3.48499146
22cytidine deamination (GO:0009972)3.47806325
23cytidine metabolic process (GO:0046087)3.47806325
24cytidine catabolic process (GO:0006216)3.47806325
25cell wall macromolecule catabolic process (GO:0016998)3.34309507
26cell wall macromolecule metabolic process (GO:0044036)3.34309507
27ribosomal small subunit biogenesis (GO:0042274)3.32395203
28centriole replication (GO:0007099)3.29571508
29cilium or flagellum-dependent cell motility (GO:0001539)3.28801216
30maturation of 5.8S rRNA (GO:0000460)3.25097008
31fusion of sperm to egg plasma membrane (GO:0007342)3.24444460
32mannosylation (GO:0097502)3.22630734
33head development (GO:0060322)3.22021193
34regulation of cilium movement (GO:0003352)3.21575401
35centriole assembly (GO:0098534)3.20437616
36somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.19622112
37isotype switching (GO:0045190)3.19622112
38somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.19622112
39ketone body metabolic process (GO:1902224)3.18687694
40postsynaptic membrane organization (GO:0001941)3.17193847
41cilium movement (GO:0003341)3.15058385
42histone exchange (GO:0043486)3.14564245
43GTP biosynthetic process (GO:0006183)3.08469218
44motile cilium assembly (GO:0044458)3.08256789
45acrosome reaction (GO:0007340)3.05396839
46DNA ligation (GO:0006266)3.05272262
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03760209
48negative regulation of cell killing (GO:0031342)3.02846162
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02846162
50execution phase of apoptosis (GO:0097194)3.02491401
51negative regulation of transcription by competitive promoter binding (GO:0010944)2.97949764
52somatic hypermutation of immunoglobulin genes (GO:0016446)2.96260698
53somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96260698
54viral transcription (GO:0019083)2.96210417
55somatic diversification of immunoglobulins (GO:0016445)2.95942176
56maturation of SSU-rRNA (GO:0030490)2.95147760
57protein heterotetramerization (GO:0051290)2.93706445
58termination of RNA polymerase I transcription (GO:0006363)2.92769664
59histone mRNA catabolic process (GO:0071044)2.92753225
60cotranslational protein targeting to membrane (GO:0006613)2.91434350
617-methylguanosine mRNA capping (GO:0006370)2.91397588
62RNA capping (GO:0036260)2.91282751
637-methylguanosine RNA capping (GO:0009452)2.91282751
64sperm motility (GO:0030317)2.91081648
65cytochrome complex assembly (GO:0017004)2.90266237
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90184668
67positive regulation of histone H3-K4 methylation (GO:0051571)2.89688336
68tRNA methylation (GO:0030488)2.88663099
69transcription elongation from RNA polymerase I promoter (GO:0006362)2.86244174
70GPI anchor biosynthetic process (GO:0006506)2.85998354
71microtubule polymerization or depolymerization (GO:0031109)2.84613612
72translational termination (GO:0006415)2.84445890
73protein targeting to ER (GO:0045047)2.84008290
74microtubule depolymerization (GO:0007019)2.80539886
75tRNA modification (GO:0006400)2.80323656
76pyrimidine ribonucleoside catabolic process (GO:0046133)2.79876959
77retinal rod cell development (GO:0046548)2.79685333
78protein localization to endoplasmic reticulum (GO:0070972)2.78889783
79DNA catabolic process, exonucleolytic (GO:0000738)2.78385937
80piRNA metabolic process (GO:0034587)2.78152011
81poly(A)+ mRNA export from nucleus (GO:0016973)2.77742790
82intraciliary transport (GO:0042073)2.72953645
83replication fork processing (GO:0031297)2.72238893
84apoptotic DNA fragmentation (GO:0006309)2.71611592
85establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70180795
86acrosome assembly (GO:0001675)2.68045238
87calcium ion-dependent exocytosis (GO:0017156)2.67030272
88ribosomal large subunit biogenesis (GO:0042273)2.66214952
89regulation of cell proliferation involved in kidney development (GO:1901722)2.66201656
90histone H3-K4 trimethylation (GO:0080182)2.65679674
91base-excision repair, AP site formation (GO:0006285)2.64047608
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63857898
93negative regulation of execution phase of apoptosis (GO:1900118)2.62694287
94protein localization to cilium (GO:0061512)2.61681329
95regulation of penile erection (GO:0060405)2.60633720
96transcription from RNA polymerase I promoter (GO:0006360)2.59555686
97lymphoid progenitor cell differentiation (GO:0002320)2.58775883
98negative regulation of telomere maintenance (GO:0032205)2.56453572
99preassembly of GPI anchor in ER membrane (GO:0016254)2.55965091
100GPI anchor metabolic process (GO:0006505)2.55752233
101cellular anion homeostasis (GO:0030002)2.55405262
102positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55209115
103negative regulation of keratinocyte proliferation (GO:0010839)2.54250106
104regulation of histone H3-K27 methylation (GO:0061085)2.53198841
105negative regulation of multicellular organism growth (GO:0040015)2.52881145
106sperm-egg recognition (GO:0035036)2.51634541
107DNA methylation involved in gamete generation (GO:0043046)2.51187695
108regulation of alpha-beta T cell proliferation (GO:0046640)2.50601485
109mesenchymal cell differentiation involved in kidney development (GO:0072161)2.50221553
110mesenchymal cell differentiation involved in renal system development (GO:2001012)2.50221553
111DNA damage response, detection of DNA damage (GO:0042769)2.49659054
112protein complex biogenesis (GO:0070271)2.48478716
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47733218
114inositol phosphate catabolic process (GO:0071545)2.46973336
115nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46905158
116guanosine-containing compound biosynthetic process (GO:1901070)2.46281559
117negative T cell selection (GO:0043383)2.45903925
118peptidyl-lysine trimethylation (GO:0018023)2.45767714
119sphingoid metabolic process (GO:0046519)2.45532298
120single fertilization (GO:0007338)2.45221722
121reproduction (GO:0000003)2.44441157
122spermatid development (GO:0007286)2.43822213
123regulation of timing of cell differentiation (GO:0048505)2.43692066
124somatic diversification of immune receptors (GO:0002200)2.42686037
125DNA replication checkpoint (GO:0000076)2.41829643
126histone H2A acetylation (GO:0043968)2.41556853
127DNA-templated transcription, elongation (GO:0006354)2.41300069
128microtubule anchoring (GO:0034453)2.41063820
129DNA replication-dependent nucleosome organization (GO:0034723)2.40540502
130DNA replication-dependent nucleosome assembly (GO:0006335)2.40540502
131protein K6-linked ubiquitination (GO:0085020)2.40516208
132histone H3-K9 methylation (GO:0051567)2.40452512
133synapsis (GO:0007129)2.40300858
134mechanoreceptor differentiation (GO:0042490)2.40146428
135female gonad development (GO:0008585)2.39881017
136keratinocyte development (GO:0003334)2.39537114
137transcription elongation from RNA polymerase II promoter (GO:0006368)2.39456408
138deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.38919343
139single strand break repair (GO:0000012)2.38874509
140positive regulation of amino acid transport (GO:0051957)2.38842683
141peptide catabolic process (GO:0043171)2.38401886
142platelet dense granule organization (GO:0060155)2.38340089
143somatic recombination of immunoglobulin gene segments (GO:0016447)2.37880085
144mesonephros development (GO:0001823)2.37722491
145nonmotile primary cilium assembly (GO:0035058)2.37249066
146rRNA catabolic process (GO:0016075)2.36907088
147negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.36777473
148C-terminal protein lipidation (GO:0006501)2.36621175
149pseudouridine synthesis (GO:0001522)2.36354755
150UTP biosynthetic process (GO:0006228)2.36328492
151cytokine biosynthetic process (GO:0042089)2.35520097
152transcription-coupled nucleotide-excision repair (GO:0006283)2.35323116
153developmental pigmentation (GO:0048066)2.34929571
154neural tube formation (GO:0001841)2.34091811
155regulation of protein glycosylation (GO:0060049)2.34023097
156cellular response to interferon-beta (GO:0035458)2.33664449
157pyrimidine nucleotide catabolic process (GO:0006244)2.33177148
158transcription initiation from RNA polymerase I promoter (GO:0006361)2.32988403
159mitochondrial respiratory chain complex I assembly (GO:0032981)2.32578546
160NADH dehydrogenase complex assembly (GO:0010257)2.32578546
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.32578546
162dopamine transport (GO:0015872)2.32087457
163tRNA processing (GO:0008033)2.31414764
164regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.30437304
165male meiosis (GO:0007140)2.30235234
166membrane repolarization during action potential (GO:0086011)2.29600299
167phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.29486068
168response to redox state (GO:0051775)2.29273582
169protein neddylation (GO:0045116)2.29109264
170CTP metabolic process (GO:0046036)2.28738787
171CTP biosynthetic process (GO:0006241)2.28738787
172positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.28292022
173intra-S DNA damage checkpoint (GO:0031573)2.28285329
174adaptation of signaling pathway (GO:0023058)2.28194981
175GMP metabolic process (GO:0046037)2.28168930
176regulation of keratinocyte proliferation (GO:0010837)2.27433428
177neutrophil mediated immunity (GO:0002446)2.27154438
178negative regulation of neurological system process (GO:0031645)2.26283969

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.34716278
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.59790195
3ZNF274_21170338_ChIP-Seq_K562_Hela3.54990387
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47015384
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37194920
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.18744611
7PCGF2_27294783_Chip-Seq_ESCs_Mouse3.05967733
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.97353358
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87977017
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.76237886
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49683917
12TAF15_26573619_Chip-Seq_HEK293_Human2.38796661
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36514627
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.35992924
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29124227
16EZH2_22144423_ChIP-Seq_EOC_Human2.25903433
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.13255298
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10569763
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05205659
20GBX2_23144817_ChIP-Seq_PC3_Human2.04511806
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.04110684
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.96533596
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90288377
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89894236
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89440968
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88891857
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88139882
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.85900786
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.85454356
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84930144
31VDR_22108803_ChIP-Seq_LS180_Human1.83570674
32FUS_26573619_Chip-Seq_HEK293_Human1.82553388
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.80803136
34E2F7_22180533_ChIP-Seq_HELA_Human1.79713076
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79020194
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74543078
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.71606966
38IRF1_19129219_ChIP-ChIP_H3396_Human1.70929137
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.68537922
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.66932517
41IGF1R_20145208_ChIP-Seq_DFB_Human1.66418615
42STAT3_18555785_Chip-Seq_ESCs_Mouse1.65563209
43RNF2_27304074_Chip-Seq_NSC_Mouse1.61910217
44P53_22387025_ChIP-Seq_ESCs_Mouse1.61437546
45NMYC_18555785_Chip-Seq_ESCs_Mouse1.60663623
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59977752
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59775476
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.59713812
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.59659062
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59480467
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.58529714
52P300_18555785_Chip-Seq_ESCs_Mouse1.56979142
53E2F1_18555785_Chip-Seq_ESCs_Mouse1.55661638
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55309359
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54294711
56P300_19829295_ChIP-Seq_ESCs_Human1.52932352
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.51738723
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51402024
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.50218853
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.48867885
61EWS_26573619_Chip-Seq_HEK293_Human1.47644473
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.47642699
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43800656
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.43330531
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41971977
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.40793924
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40299361
68* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39480742
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.39409971
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39409971
71KLF4_18555785_Chip-Seq_ESCs_Mouse1.38093620
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37828291
73ZFX_18555785_Chip-Seq_ESCs_Mouse1.37264474
74SOX2_19829295_ChIP-Seq_ESCs_Human1.33908170
75NANOG_19829295_ChIP-Seq_ESCs_Human1.33908170
76ER_23166858_ChIP-Seq_MCF-7_Human1.33440134
77ELK1_19687146_ChIP-ChIP_HELA_Human1.33410836
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.32251214
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.31323008
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30834649
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.30806202
82VDR_23849224_ChIP-Seq_CD4+_Human1.28857788
83GATA3_26560356_Chip-Seq_TH2_Human1.28350016
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26326487
85BCAT_22108803_ChIP-Seq_LS180_Human1.26251071
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25958383
87CBP_20019798_ChIP-Seq_JUKART_Human1.25514786
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25514786
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24100648
90PU1_27457419_Chip-Seq_LIVER_Mouse1.24031255
91SMAD1_18555785_Chip-Seq_ESCs_Mouse1.21575924
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20971050
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17934847
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.16205405
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15595359
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15568612
97TCF4_22108803_ChIP-Seq_LS180_Human1.15154100
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12728974
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11748623
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10476772
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10167496
102AR_20517297_ChIP-Seq_VCAP_Human1.10031488
103* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09750102
104FOXP3_21729870_ChIP-Seq_TREG_Human1.09077430
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08962392
106TP53_22573176_ChIP-Seq_HFKS_Human1.08266178
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08176651
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.06747155
109SMAD4_21799915_ChIP-Seq_A2780_Human1.06069816
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05960361
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04887370
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04807463
113MYB_26560356_Chip-Seq_TH2_Human1.03986407
114* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01044790
115MYB_26560356_Chip-Seq_TH1_Human1.00500388
116TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98954304
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98536130
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98142264
119MYC_18940864_ChIP-ChIP_HL60_Human0.98123892
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.97453564
121GATA3_27048872_Chip-Seq_THYMUS_Human0.97351684
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97333931
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97009995
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96863561
125GATA3_21878914_ChIP-Seq_MCF-7_Human0.96296886
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96286033
127CDX2_22108803_ChIP-Seq_LS180_Human0.96161849
128TCF4_23295773_ChIP-Seq_U87_Human0.95549247
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95395341
130KDM2B_26808549_Chip-Seq_REH_Human0.95064467
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94012425
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94012425
133AR_25329375_ChIP-Seq_VCAP_Human0.93942800
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93563678
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93407423
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.92058014
137* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92048451
138CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91743064
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91638843
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91345646
141LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90092905
142MYC_18555785_ChIP-Seq_MESCs_Mouse0.89897277
143RBPJ_21746931_ChIP-Seq_IB4_Human0.89826874
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.86278985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.18649352
2MP0003787_abnormal_imprinting3.75727196
3MP0009379_abnormal_foot_pigmentation3.67642779
4MP0001188_hyperpigmentation3.60926342
5MP0005409_darkened_coat_color3.43990696
6MP0006292_abnormal_olfactory_placode3.38197459
7MP0004381_abnormal_hair_follicle3.21872139
8MP0001485_abnormal_pinna_reflex2.98652747
9MP0000015_abnormal_ear_pigmentation2.82114339
10MP0001986_abnormal_taste_sensitivity2.78413883
11MP0000569_abnormal_digit_pigmentation2.69213894
12MP0000566_synostosis2.48074028
13MP0005410_abnormal_fertilization2.35206925
14MP0002009_preneoplasia2.22527102
15MP0003880_abnormal_central_pattern2.21694267
16MP0005174_abnormal_tail_pigmentation2.15263819
17MP0003941_abnormal_skin_development2.12596309
18MP0005171_absent_coat_pigmentation2.10654775
19MP0000372_irregular_coat_pigmentation2.08913355
20MP0008058_abnormal_DNA_repair1.93933388
21MP0002095_abnormal_skin_pigmentation1.85637228
22MP0005075_abnormal_melanosome_morpholog1.81714060
23MP0005310_abnormal_salivary_gland1.77525595
24MP0003045_fibrosis1.72930539
25MP0008004_abnormal_stomach_pH1.72759554
26MP0008872_abnormal_physiological_respon1.71616317
27MP0002254_reproductive_system_inflammat1.68716225
28MP0002396_abnormal_hematopoietic_system1.63519741
29MP0002277_abnormal_respiratory_mucosa1.60608257
30MP0002132_abnormal_respiratory_system1.60108071
31MP0008875_abnormal_xenobiotic_pharmacok1.59197366
32MP0005671_abnormal_response_to1.57427982
33MP0003724_increased_susceptibility_to1.56523223
34MP0003763_abnormal_thymus_physiology1.54830905
35MP0008877_abnormal_DNA_methylation1.53109521
36MP0001984_abnormal_olfaction1.51482250
37MP0003786_premature_aging1.48960725
38MP0002163_abnormal_gland_morphology1.45361016
39MP0001873_stomach_inflammation1.44241715
40MP0002102_abnormal_ear_morphology1.42192335
41MP0002736_abnormal_nociception_after1.39027161
42MP0003693_abnormal_embryo_hatching1.38775027
43MP0005646_abnormal_pituitary_gland1.37435586
44MP0009697_abnormal_copulation1.36489355
45MP0005253_abnormal_eye_physiology1.36248433
46MP0001929_abnormal_gametogenesis1.34539799
47MP0000685_abnormal_immune_system1.34325366
48MP0002210_abnormal_sex_determination1.33845928
49MP0006072_abnormal_retinal_apoptosis1.33189828
50MP0003121_genomic_imprinting1.32078514
51MP0008007_abnormal_cellular_replicative1.31351421
52MP0003698_abnormal_male_reproductive1.28291476
53MP0005379_endocrine/exocrine_gland_phen1.27875789
54MP0003436_decreased_susceptibility_to1.27433387
55MP0001968_abnormal_touch/_nociception1.26686330
56MP0002177_abnormal_outer_ear1.26626509
57MP0008057_abnormal_DNA_replication1.25610098
58MP0003195_calcinosis1.24656813
59MP0003315_abnormal_perineum_morphology1.23979208
60MP0002938_white_spotting1.23282513
61MP0001835_abnormal_antigen_presentation1.22166242
62MP0003950_abnormal_plasma_membrane1.19195642
63MP0009764_decreased_sensitivity_to1.19032595
64MP0004885_abnormal_endolymph1.17477619
65MP0004142_abnormal_muscle_tone1.15354682
66MP0000049_abnormal_middle_ear1.14429060
67MP0003806_abnormal_nucleotide_metabolis1.12458580
68MP0001905_abnormal_dopamine_level1.08256925
69MP0006082_CNS_inflammation1.08215533
70MP0003718_maternal_effect1.08175874
71MP0002909_abnormal_adrenal_gland1.08074873
72MP0002249_abnormal_larynx_morphology1.07502048
73MP0000689_abnormal_spleen_morphology1.07364731
74MP0009785_altered_susceptibility_to1.07001969
75MP0002148_abnormal_hypersensitivity_rea1.06223484
76MP0009333_abnormal_splenocyte_physiolog1.06153951
77MP0004742_abnormal_vestibular_system1.05704030
78MP0001764_abnormal_homeostasis1.05479870
79MP0005367_renal/urinary_system_phenotyp1.05101015
80MP0000516_abnormal_urinary_system1.05101015
81MP0008260_abnormal_autophagy1.02612048
82MP0002234_abnormal_pharynx_morphology1.02375627
83MP0009250_abnormal_appendicular_skeleto1.02341482
84MP0000465_gastrointestinal_hemorrhage0.99507307
85MP0002405_respiratory_system_inflammati0.99328938
86MP0005423_abnormal_somatic_nervous0.97732011
87MP0000631_abnormal_neuroendocrine_gland0.96041224
88MP0000490_abnormal_crypts_of0.95883113
89MP0002138_abnormal_hepatobiliary_system0.94385502
90MP0001145_abnormal_male_reproductive0.92965424
91MP0010094_abnormal_chromosome_stability0.92551387
92MP0000026_abnormal_inner_ear0.91678509
93MP0008995_early_reproductive_senescence0.91360380
94MP0004130_abnormal_muscle_cell0.91056856
95MP0008873_increased_physiological_sensi0.90951638
96MP0002098_abnormal_vibrissa_morphology0.89899884
97MP0002398_abnormal_bone_marrow0.88369538
98MP0000681_abnormal_thyroid_gland0.87657963
99MP0000653_abnormal_sex_gland0.87139224
100MP0003938_abnormal_ear_development0.86903502
101MP0002837_dystrophic_cardiac_calcinosis0.86232130
102MP0005084_abnormal_gallbladder_morpholo0.86036591
103MP0000716_abnormal_immune_system0.85252476
104MP0005000_abnormal_immune_tolerance0.85186552
105MP0002722_abnormal_immune_system0.84677425
106MP0000427_abnormal_hair_cycle0.84196631
107MP0002419_abnormal_innate_immunity0.83962228
108MP0001919_abnormal_reproductive_system0.81644566
109MP0003011_delayed_dark_adaptation0.81195546
110MP0004883_abnormal_blood_vessel0.80449361
111MP0006276_abnormal_autonomic_nervous0.80216008
112MP0002638_abnormal_pupillary_reflex0.79572740
113MP0008789_abnormal_olfactory_epithelium0.78905268
114MP0002168_other_aberrant_phenotype0.77015810
115MP0001529_abnormal_vocalization0.76929346
116MP0006036_abnormal_mitochondrial_physio0.76734613
117MP0003866_abnormal_defecation0.76623162
118MP0000703_abnormal_thymus_morphology0.76028808
119MP0001186_pigmentation_phenotype0.75313100
120MP0003646_muscle_fatigue0.75118406
121MP0005647_abnormal_sex_gland0.75009803
122MP0005395_other_phenotype0.74596282
123MP0001119_abnormal_female_reproductive0.74463782
124MP0006035_abnormal_mitochondrial_morpho0.74456099
125MP0002876_abnormal_thyroid_physiology0.74348967
126MP0000613_abnormal_salivary_gland0.73989357
127MP0004147_increased_porphyrin_level0.73610711
128MP0001851_eye_inflammation0.73399872
129MP0002019_abnormal_tumor_incidence0.72786604
130MP0005551_abnormal_eye_electrophysiolog0.72621473
131MP0001800_abnormal_humoral_immune0.72400241
132MP0001346_abnormal_lacrimal_gland0.71830246
133MP0001963_abnormal_hearing_physiology0.70738095
134MP0001819_abnormal_immune_cell0.70599131
135MP0002420_abnormal_adaptive_immunity0.70273493
136MP0005394_taste/olfaction_phenotype0.69925369
137MP0005499_abnormal_olfactory_system0.69925369
138MP0002723_abnormal_immune_serum0.69861046
139MP0005025_abnormal_response_to0.69583418
140MP0005451_abnormal_body_composition0.69165366
141MP0002452_abnormal_antigen_presenting0.68204906
142MP0002933_joint_inflammation0.67387351
143MP0002160_abnormal_reproductive_system0.67361289
144MP0001853_heart_inflammation0.67069645
145MP0001790_abnormal_immune_system0.66978373
146MP0005387_immune_system_phenotype0.66978373
147MP0000678_abnormal_parathyroid_gland0.66376531
148MP0005645_abnormal_hypothalamus_physiol0.66012377
149MP0005389_reproductive_system_phenotype0.64027829
150MP0002067_abnormal_sensory_capabilities0.63702387
151MP0003936_abnormal_reproductive_system0.62596644
152MP0003828_pulmonary_edema0.61341140

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.60283959
2Absent/shortened dynein arms (HP:0200106)4.60283959
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.00255895
4Abnormal respiratory motile cilium morphology (HP:0005938)3.85685543
5Abnormal respiratory epithelium morphology (HP:0012253)3.85685543
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.68116996
7Increased IgM level (HP:0003496)3.63306100
8Volvulus (HP:0002580)3.51770878
9Autoimmune hemolytic anemia (HP:0001890)3.34059739
10Type I transferrin isoform profile (HP:0003642)3.33642831
11Aplasia/Hypoplasia of the sternum (HP:0006714)3.32386560
12Abnormal respiratory motile cilium physiology (HP:0012261)3.23992288
13Eosinophilia (HP:0001880)3.22190826
14Abnormal ciliary motility (HP:0012262)3.17741638
15Congenital stationary night blindness (HP:0007642)3.12011834
163-Methylglutaconic aciduria (HP:0003535)3.08166347
17Nonprogressive disorder (HP:0003680)2.99318193
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95868867
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95868867
20Abnormality of T cell number (HP:0011839)2.95454144
21Abnormality of the axillary hair (HP:0100134)2.93364505
22Abnormality of secondary sexual hair (HP:0009888)2.93364505
23IgG deficiency (HP:0004315)2.88222801
24Hypothermia (HP:0002045)2.83509287
25Increased CSF lactate (HP:0002490)2.81293073
26True hermaphroditism (HP:0010459)2.80565625
27Stomatitis (HP:0010280)2.80328731
28Dry hair (HP:0011359)2.71498661
29Autoimmune thrombocytopenia (HP:0001973)2.67772149
30Abnormality of the labia minora (HP:0012880)2.66098478
31Abnormality of eosinophils (HP:0001879)2.65242707
32Type 2 muscle fiber atrophy (HP:0003554)2.64340984
33Progressive macrocephaly (HP:0004481)2.63143179
34Reduced antithrombin III activity (HP:0001976)2.59978980
35Acute encephalopathy (HP:0006846)2.58894599
36Medial flaring of the eyebrow (HP:0010747)2.56933539
37Patchy hypopigmentation of hair (HP:0011365)2.56001221
38Bilateral microphthalmos (HP:0007633)2.54149468
39Rhinitis (HP:0012384)2.52564700
40Abnormality of cells of the erythroid lineage (HP:0012130)2.51929434
41Abnormal mitochondria in muscle tissue (HP:0008316)2.51320726
42Abnormal hair whorl (HP:0010721)2.48295499
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47021894
44Neutropenia (HP:0001875)2.46014498
45Progressive inability to walk (HP:0002505)2.42988551
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42575149
47Abnormality of the ileum (HP:0001549)2.42395086
48Abnormal number of erythroid precursors (HP:0012131)2.42046442
49Supernumerary spleens (HP:0009799)2.41690374
50Abnormality of T cell physiology (HP:0011840)2.39926301
51Duplicated collecting system (HP:0000081)2.38248795
52Granulocytopenia (HP:0001913)2.37294335
53Reticulocytopenia (HP:0001896)2.36868024
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36409213
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36046012
56Optic nerve hypoplasia (HP:0000609)2.33866521
57Abnormal protein glycosylation (HP:0012346)2.32179380
58Abnormal glycosylation (HP:0012345)2.32179380
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32179380
60Abnormal protein N-linked glycosylation (HP:0012347)2.32179380
61Abnormality of the renal collecting system (HP:0004742)2.29742620
62Retinal dysplasia (HP:0007973)2.28938649
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.28299770
64Pancreatic fibrosis (HP:0100732)2.28194526
65Abnormality of T cells (HP:0002843)2.27929203
66Amyotrophic lateral sclerosis (HP:0007354)2.26657476
67Thyroid-stimulating hormone excess (HP:0002925)2.24378768
68Absent speech (HP:0001344)2.24346483
69Nephronophthisis (HP:0000090)2.24101946
70Pancreatic cysts (HP:0001737)2.23313408
71White forelock (HP:0002211)2.22694061
72Increased hepatocellular lipid droplets (HP:0006565)2.22629695
73Anhidrosis (HP:0000970)2.20591868
74Absent thumb (HP:0009777)2.20335086
75Renal Fanconi syndrome (HP:0001994)2.20223099
76Muscle fiber atrophy (HP:0100295)2.18220320
77Thyroiditis (HP:0100646)2.17789129
78Hypochromic anemia (HP:0001931)2.17077598
79Parakeratosis (HP:0001036)2.16135673
80Short tibia (HP:0005736)2.14670207
81Tubulointerstitial nephritis (HP:0001970)2.13707112
82Meckel diverticulum (HP:0002245)2.12935018
83Adactyly (HP:0009776)2.12252744
84Cellular immunodeficiency (HP:0005374)2.10607973
85Molar tooth sign on MRI (HP:0002419)2.09545420
86Abnormality of midbrain morphology (HP:0002418)2.09545420
87Intestinal atresia (HP:0011100)2.09380368
88Neuroendocrine neoplasm (HP:0100634)2.09308987
89Abnormality of the phalanges of the hallux (HP:0010057)2.09249743
90Panhypogammaglobulinemia (HP:0003139)2.08809780
91Abnormal sex determination (HP:0012244)2.07944152
92Sex reversal (HP:0012245)2.07944152
93Attenuation of retinal blood vessels (HP:0007843)2.05983681
94Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05623801
95Hyperventilation (HP:0002883)2.05585655
96Hepatic necrosis (HP:0002605)2.04592196
97Abnormality of the columella (HP:0009929)2.03859352
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03330234
99Chromsome breakage (HP:0040012)2.02927085
100Optic disc pallor (HP:0000543)2.01261385
101Pheochromocytoma (HP:0002666)2.00858303
102Hyperglycinemia (HP:0002154)2.00566451
103Optic neuritis (HP:0100653)2.00532846
104Retrobulbar optic neuritis (HP:0100654)2.00532846
105Microvesicular hepatic steatosis (HP:0001414)2.00387526
106Median cleft lip (HP:0000161)1.99231828
107Pendular nystagmus (HP:0012043)1.99025794
108Aplasia/hypoplasia of the uterus (HP:0008684)1.98179511
109Abnormality of the preputium (HP:0100587)1.98113620
110Mitochondrial inheritance (HP:0001427)1.97603163
111Abnormality of incisor morphology (HP:0011063)1.97352018
112Widely spaced teeth (HP:0000687)1.97191638
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95007060
114Hypoplasia of the fovea (HP:0007750)1.94549858
115Aplasia/Hypoplasia of the fovea (HP:0008060)1.94549858
116Abnormality of renal resorption (HP:0011038)1.93186871
117Severe combined immunodeficiency (HP:0004430)1.93106834
118Exertional dyspnea (HP:0002875)1.92732892
119Triphalangeal thumb (HP:0001199)1.91843367
120Cupped ear (HP:0000378)1.91180640
121Macrocytic anemia (HP:0001972)1.90874285
122Abnormality of chromosome stability (HP:0003220)1.89493144
123Abnormality of DNA repair (HP:0003254)1.88453289
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.87910167
125Preaxial hand polydactyly (HP:0001177)1.87722394
126Leukocytosis (HP:0001974)1.87391030
127T lymphocytopenia (HP:0005403)1.86822851
128Broad alveolar ridges (HP:0000187)1.86693086
129Dyschromatopsia (HP:0007641)1.86510786
130Congenital sensorineural hearing impairment (HP:0008527)1.86108495
131Birth length less than 3rd percentile (HP:0003561)1.83032206
132Abnormality of the renal medulla (HP:0100957)1.82653430
133Bronchiectasis (HP:0002110)1.82403982
134Abnormal spermatogenesis (HP:0008669)1.80989997
135Abnormal rod and cone electroretinograms (HP:0008323)1.80726243
136Type II lissencephaly (HP:0007260)1.80552543
137Abnormal lung lobation (HP:0002101)1.79613368
138Hepatocellular necrosis (HP:0001404)1.78964282
139Acute necrotizing encephalopathy (HP:0006965)1.78582794
140Amelogenesis imperfecta (HP:0000705)1.78261722
141Concave nail (HP:0001598)1.78003122
142Ectopic kidney (HP:0000086)1.77419001
143Chronic mucocutaneous candidiasis (HP:0002728)1.77402500
144Recurrent cutaneous fungal infections (HP:0011370)1.77402500
145Conical tooth (HP:0000698)1.77133548
146Abolished electroretinogram (ERG) (HP:0000550)1.74521681
147Large for gestational age (HP:0001520)1.73942714
148Respiratory difficulties (HP:0002880)1.73686662
149Congenital primary aphakia (HP:0007707)1.72413906
150Severe visual impairment (HP:0001141)1.71225896
151Anencephaly (HP:0002323)1.70099118
152Septo-optic dysplasia (HP:0100842)1.69853114
153Nephrogenic diabetes insipidus (HP:0009806)1.69620726
154Postaxial foot polydactyly (HP:0001830)1.69443106
155Retinitis pigmentosa (HP:0000510)1.69178956
156Constricted visual fields (HP:0001133)1.68777694
157Combined immunodeficiency (HP:0005387)1.68641077
158Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67021852
159Depressed nasal tip (HP:0000437)1.66849483
160Duodenal stenosis (HP:0100867)1.65198782
161Small intestinal stenosis (HP:0012848)1.65198782
162Abnormality of the fovea (HP:0000493)1.64949076
163Methylmalonic aciduria (HP:0012120)1.64757962
164Abnormality of B cell number (HP:0010975)1.63715511
165Gait imbalance (HP:0002141)1.63624379
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.63604840
167Adrenal hypoplasia (HP:0000835)1.62595871
168Clubbing of toes (HP:0100760)1.61995055
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.61372033
170Lipid accumulation in hepatocytes (HP:0006561)1.60758986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.70340012
2CASK5.36474357
3WNK35.18132022
4MUSK3.28714239
5TNIK3.12112351
6MKNK23.05189871
7NME22.58406600
8MKNK12.23618898
9STK162.20614773
10TXK2.10613919
11NLK2.04966543
12NEK22.00642620
13SRPK11.98879551
14BMPR1B1.96832512
15VRK11.80481702
16MST41.76618408
17TLK11.75559972
18MAP3K141.75283306
19CDK31.74870998
20MAP4K21.69442358
21CCNB11.65697303
22MAP3K61.65499969
23IRAK31.63313182
24MAP2K31.61004187
25CDK81.57311175
26MAPK151.51976981
27SIK31.48451043
28MAP3K121.48406900
29NEK61.47679752
30IRAK41.44817405
31MAPK131.42912823
32YES11.31715887
33BMPR21.29180624
34ACVR1B1.27140812
35PRKD21.25055576
36TRIM281.23486460
37CLK11.22271811
38IRAK11.20234443
39STK241.18654570
40PLK41.12365020
41TEC1.09923377
42PRKD31.09348986
43EIF2AK21.08958584
44STK41.06469035
45EIF2AK31.03588351
46VRK21.02998710
47STK391.01633592
48MINK11.00480595
49GRK70.97890204
50MAPKAPK50.96316250
51GRK10.96105010
52KIT0.92926168
53TAOK30.92320277
54MAP2K60.90995043
55STK380.89004592
56BRSK20.88814997
57BLK0.88781907
58PRPF4B0.88474777
59ADRBK20.87714743
60STK38L0.85179097
61WEE10.85122732
62ZAK0.84958608
63CSNK1G10.84279048
64PIM20.83710565
65AKT30.80481773
66ZAP700.79710303
67ERBB30.78791791
68ADRBK10.76087273
69PIM10.75339437
70IKBKB0.71896586
71BUB10.71413965
72CDK190.69142558
73TNK20.69083102
74MAP3K50.68838920
75CDK90.68222302
76MARK30.67738261
77NME10.66711172
78PRKG20.66080557
79OXSR10.65863348
80GRK60.64051931
81CSNK1G20.63056664
82MAP4K10.61588815
83JAK30.59068485
84PBK0.58246761
85BCR0.56890547
86TSSK60.56046247
87IKBKE0.55962206
88ITK0.55526568
89FES0.55142086
90CSNK1G30.54848852
91PLK20.54573662
92CAMKK20.52706029
93PKN10.51330908
94IRAK20.50599485
95PDK40.50001495
96PDK30.50001495
97RPS6KA50.49090372
98MAP2K40.49068342
99EIF2AK10.48727189
100MAP2K70.48453386
101CDK70.48351218
102TIE10.48225323
103WNK40.47988163
104PDK20.47893597
105CHEK20.47191363
106SGK20.47181603
107LYN0.47122333
108BTK0.46716002
109PINK10.46317210
110DYRK20.46269893
111HIPK20.46266570
112FRK0.44974810
113STK100.44534344
114LCK0.44178143
115RPS6KA40.42997698
116PRKCE0.42824137
117ATM0.41855999
118MAP3K90.40979326
119ATR0.40930728
120STK110.40519467
121PRKCG0.38401800
122CSNK2A10.37685615
123PLK10.37685517
124PIK3CA0.37600923
125TRPM70.35925867
126PLK30.35030828
127SYK0.34710296
128RPS6KB10.33822552
129RIPK40.33462935
130DYRK30.33171243
131PRKCQ0.33023425
132RET0.32920354
133CSNK2A20.32884541
134INSRR0.32808825
135MYLK0.32522423
136CAMK2B0.32098788
137ABL10.31943951
138BRD40.30484728
139CSNK1A1L0.30286063
140NUAK10.29823564
141KDR0.28731892
142TGFBR10.28496356
143TYK20.28383980
144CDC70.23997036
145ALK0.23731580
146CSF1R0.22992797
147EPHA30.22410538

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.68032633
2RNA polymerase_Homo sapiens_hsa030203.58827899
3Basal transcription factors_Homo sapiens_hsa030223.03038960
4Protein export_Homo sapiens_hsa030602.97981128
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87161192
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49063482
7Fanconi anemia pathway_Homo sapiens_hsa034602.42913592
8Homologous recombination_Homo sapiens_hsa034402.42056112
9Caffeine metabolism_Homo sapiens_hsa002322.30302636
10Oxidative phosphorylation_Homo sapiens_hsa001902.02060336
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01304770
12Pyrimidine metabolism_Homo sapiens_hsa002401.92126831
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89516807
14Nitrogen metabolism_Homo sapiens_hsa009101.84616882
15DNA replication_Homo sapiens_hsa030301.77012098
16Non-homologous end-joining_Homo sapiens_hsa034501.74061311
17Proteasome_Homo sapiens_hsa030501.72760128
18RNA degradation_Homo sapiens_hsa030181.72614631
19Sphingolipid metabolism_Homo sapiens_hsa006001.72367789
20Mismatch repair_Homo sapiens_hsa034301.72051412
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58286524
22Huntingtons disease_Homo sapiens_hsa050161.57678705
23Nucleotide excision repair_Homo sapiens_hsa034201.57034402
24Spliceosome_Homo sapiens_hsa030401.56978687
25Purine metabolism_Homo sapiens_hsa002301.52853751
26Arachidonic acid metabolism_Homo sapiens_hsa005901.51527364
27Parkinsons disease_Homo sapiens_hsa050121.49959246
28Sulfur relay system_Homo sapiens_hsa041221.47711957
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43871407
30Ether lipid metabolism_Homo sapiens_hsa005651.36668990
31Graft-versus-host disease_Homo sapiens_hsa053321.36413963
32Primary immunodeficiency_Homo sapiens_hsa053401.35999625
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.35602623
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28575791
35Peroxisome_Homo sapiens_hsa041461.27932385
36Phototransduction_Homo sapiens_hsa047441.23738334
37Butanoate metabolism_Homo sapiens_hsa006501.19868443
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18275772
39Linoleic acid metabolism_Homo sapiens_hsa005911.16229522
40Alzheimers disease_Homo sapiens_hsa050101.15439735
41Hematopoietic cell lineage_Homo sapiens_hsa046401.13309574
42Allograft rejection_Homo sapiens_hsa053301.12399080
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09217153
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.07758255
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07740586
46Autoimmune thyroid disease_Homo sapiens_hsa053201.02801084
47Base excision repair_Homo sapiens_hsa034101.01137704
48Folate biosynthesis_Homo sapiens_hsa007900.91882826
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91296106
50Measles_Homo sapiens_hsa051620.90154142
51Herpes simplex infection_Homo sapiens_hsa051680.89961398
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89543834
53Asthma_Homo sapiens_hsa053100.89404269
54Dorso-ventral axis formation_Homo sapiens_hsa043200.89168673
55Rheumatoid arthritis_Homo sapiens_hsa053230.87712977
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87342761
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.85587854
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80405201
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78798081
60Cell cycle_Homo sapiens_hsa041100.77054615
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76773947
62Malaria_Homo sapiens_hsa051440.74507531
63Propanoate metabolism_Homo sapiens_hsa006400.73301570
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72743579
65Serotonergic synapse_Homo sapiens_hsa047260.72252739
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71362959
67RNA transport_Homo sapiens_hsa030130.69873535
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68733475
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68586343
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67859312
71mRNA surveillance pathway_Homo sapiens_hsa030150.66586979
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63598509
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63266163
74Antigen processing and presentation_Homo sapiens_hsa046120.62116175
75Other glycan degradation_Homo sapiens_hsa005110.61595263
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60689787
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60654970
78Epstein-Barr virus infection_Homo sapiens_hsa051690.59322318
79Vitamin digestion and absorption_Homo sapiens_hsa049770.57978212
80Fatty acid elongation_Homo sapiens_hsa000620.56653313
81Taste transduction_Homo sapiens_hsa047420.56617512
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.56432450
83Chemical carcinogenesis_Homo sapiens_hsa052040.55419448
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54623334
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54511950
86p53 signaling pathway_Homo sapiens_hsa041150.52902411
87Leishmaniasis_Homo sapiens_hsa051400.50969523
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.50895714
89Fatty acid metabolism_Homo sapiens_hsa012120.49456413
90Regulation of autophagy_Homo sapiens_hsa041400.48873038
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46319184
92ABC transporters_Homo sapiens_hsa020100.46252833
93Metabolic pathways_Homo sapiens_hsa011000.46110984
94Collecting duct acid secretion_Homo sapiens_hsa049660.44953538
95T cell receptor signaling pathway_Homo sapiens_hsa046600.43353684
96Nicotine addiction_Homo sapiens_hsa050330.43150504
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41536612
98Basal cell carcinoma_Homo sapiens_hsa052170.40655453
99Prostate cancer_Homo sapiens_hsa052150.40347819
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40071556
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39926331
102Wnt signaling pathway_Homo sapiens_hsa043100.39863002
103N-Glycan biosynthesis_Homo sapiens_hsa005100.38660522
104One carbon pool by folate_Homo sapiens_hsa006700.38482570
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38427736
106Retinol metabolism_Homo sapiens_hsa008300.38191861
107Influenza A_Homo sapiens_hsa051640.35540850
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.35451595
109Cardiac muscle contraction_Homo sapiens_hsa042600.34943832
110Tryptophan metabolism_Homo sapiens_hsa003800.34083355
111African trypanosomiasis_Homo sapiens_hsa051430.30375504
112Long-term depression_Homo sapiens_hsa047300.29806366
113Mineral absorption_Homo sapiens_hsa049780.28759382
114TNF signaling pathway_Homo sapiens_hsa046680.26766527
115Type I diabetes mellitus_Homo sapiens_hsa049400.26528145
116Steroid biosynthesis_Homo sapiens_hsa001000.25867785
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24618931
118Glutathione metabolism_Homo sapiens_hsa004800.24442928
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24387914
120Selenocompound metabolism_Homo sapiens_hsa004500.22218520
121Vitamin B6 metabolism_Homo sapiens_hsa007500.21806134
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21065477
123Sulfur metabolism_Homo sapiens_hsa009200.20027776
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.19454602
125Morphine addiction_Homo sapiens_hsa050320.18992703
126Hepatitis C_Homo sapiens_hsa051600.18942860
127Legionellosis_Homo sapiens_hsa051340.18125343

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