ASTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.69993791
2regulation of acrosome reaction (GO:0060046)7.95186590
3citrulline biosynthetic process (GO:0019240)7.42548479
4base-excision repair, AP site formation (GO:0006285)7.36844097
5regulation of meiosis (GO:0040020)6.93868234
6female gamete generation (GO:0007292)6.89674194
7mitotic chromosome condensation (GO:0007076)6.77481060
8histone H2A monoubiquitination (GO:0035518)6.74512855
9regulation of DNA methylation (GO:0044030)6.73780780
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.67062744
11multicellular organism reproduction (GO:0032504)6.54193068
12histone H2A ubiquitination (GO:0033522)6.34349485
13DNA methylation involved in gamete generation (GO:0043046)6.14621278
14negative regulation of meiotic cell cycle (GO:0051447)6.11738678
15meiotic cell cycle (GO:0051321)6.03575228
16negative regulation of meiosis (GO:0045835)6.00798224
17mitotic metaphase plate congression (GO:0007080)5.87925099
18regulation of hypersensitivity (GO:0002883)5.76998967
19protein K6-linked ubiquitination (GO:0085020)5.63108147
20pyrimidine nucleotide catabolic process (GO:0006244)5.59511234
21regulation of exit from mitosis (GO:0007096)5.55383583
22regulation of meiotic cell cycle (GO:0051445)5.47147892
23protein localization to kinetochore (GO:0034501)5.27263719
24oocyte development (GO:0048599)5.16402222
25oocyte maturation (GO:0001556)5.08249112
26reproduction (GO:0000003)4.94649153
27negative regulation of smooth muscle cell differentiation (GO:0051151)4.93057880
28regulation of calcium ion-dependent exocytosis (GO:0017158)4.86619214
29B cell mediated immunity (GO:0019724)4.86349207
30metaphase plate congression (GO:0051310)4.86124590
31sperm-egg recognition (GO:0035036)4.80969551
32negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.78867131
33regulation of phospholipid biosynthetic process (GO:0071071)4.76958290
34positive regulation of humoral immune response (GO:0002922)4.72198475
35regulation of inflammatory response to antigenic stimulus (GO:0002861)4.67843909
36attachment of spindle microtubules to kinetochore (GO:0008608)4.67238423
37protein localization to chromosome, centromeric region (GO:0071459)4.65586377
38regulation of histone H3-K27 methylation (GO:0061085)4.56785705
39positive regulation of calcium ion import (GO:0090280)4.51516740
40positive regulation of interleukin-4 production (GO:0032753)4.51211945
41citrulline metabolic process (GO:0000052)4.47570367
42regulation of sister chromatid cohesion (GO:0007063)4.43854614
43positive regulation of acute inflammatory response (GO:0002675)4.43822165
44establishment of chromosome localization (GO:0051303)4.41059989
45mitotic sister chromatid segregation (GO:0000070)4.38408128
46positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.38255010
47negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.29681470
48notochord development (GO:0030903)4.27123485
49protein kinase C signaling (GO:0070528)4.26497350
50male meiosis (GO:0007140)4.25981535
51gene silencing by RNA (GO:0031047)4.08363428
52regulation of vitamin D biosynthetic process (GO:0060556)4.06205684
53peptidyl-arginine modification (GO:0018195)4.05128075
54microtubule severing (GO:0051013)4.03785003
55negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.02002094
56negative regulation of DNA-templated transcription, elongation (GO:0032785)4.02002094
57protein localization to chromosome (GO:0034502)4.00050314
58positive regulation of reproductive process (GO:2000243)3.99468325
59ovulation cycle (GO:0042698)3.99459761
60cell-cell recognition (GO:0009988)3.95747966
61establishment of spindle localization (GO:0051293)3.88236970
62regulation of steroid hormone secretion (GO:2000831)3.85432538
63DNA methylation (GO:0006306)3.82793366
64DNA alkylation (GO:0006305)3.82793366
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.80869202
66negative regulation of histone methylation (GO:0031061)3.79573251
67regulation of histone H3-K9 methylation (GO:0051570)3.79274416
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.77494585
69regulation of interleukin-4 production (GO:0032673)3.76996131
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.74720567
71chaperone-mediated protein transport (GO:0072321)3.72086590
72regulation of retinoic acid receptor signaling pathway (GO:0048385)3.69429897
73regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.67607762
74DNA damage induced protein phosphorylation (GO:0006975)3.67056538
75single fertilization (GO:0007338)3.61394710
76immunoglobulin mediated immune response (GO:0016064)3.60056179
77chromosome segregation (GO:0007059)3.57326596
78positive regulation of chromosome segregation (GO:0051984)3.55461567
79sister chromatid segregation (GO:0000819)3.53569757
80regulation of spindle organization (GO:0090224)3.52883955
81regulation of chronic inflammatory response (GO:0002676)3.50366600
82regulation of mitotic spindle organization (GO:0060236)3.49410599
83binding of sperm to zona pellucida (GO:0007339)3.48168584
84* negative regulation of reproductive process (GO:2000242)3.44718576
85CENP-A containing nucleosome assembly (GO:0034080)3.41839141
86endothelium development (GO:0003158)3.40902249
87positive regulation of meiosis (GO:0045836)3.40362751
88positive regulation of interleukin-1 beta secretion (GO:0050718)3.39690239
89phosphatidylglycerol biosynthetic process (GO:0006655)3.38089893
90spindle checkpoint (GO:0031577)3.37241697
91histone H3-K4 trimethylation (GO:0080182)3.35083204
92histone monoubiquitination (GO:0010390)3.34126230
93establishment of spindle orientation (GO:0051294)3.33554581
94positive regulation of heat generation (GO:0031652)3.33037280
95* fertilization (GO:0009566)3.32326795
96meiotic chromosome segregation (GO:0045132)3.28836615
97positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25694806
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.25694806
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25694806
100regulation of fever generation (GO:0031620)3.23287510
101chromatin remodeling at centromere (GO:0031055)3.23069465
102glycerophospholipid catabolic process (GO:0046475)3.22375491
103regulation of chromosome segregation (GO:0051983)3.21380261
104positive regulation of meiotic cell cycle (GO:0051446)3.20074676
105regulation of interleukin-1 beta secretion (GO:0050706)3.18974256
106histone lysine demethylation (GO:0070076)3.18720462
107histone exchange (GO:0043486)3.17559859
108histone H3-K36 demethylation (GO:0070544)3.16517891
109positive regulation of interleukin-1 secretion (GO:0050716)3.16382767
110regulation of vitamin metabolic process (GO:0030656)3.14974070
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12825193
112regulation of meiosis I (GO:0060631)3.10976673
113DNA modification (GO:0006304)3.10951522
114regulation of NFAT protein import into nucleus (GO:0051532)3.10482814
115negative regulation of nuclear division (GO:0051784)3.08851317
116histone demethylation (GO:0016577)3.07567906
117oogenesis (GO:0048477)3.07463519
118mitotic nuclear envelope disassembly (GO:0007077)3.07459141
119chromatin assembly or disassembly (GO:0006333)3.07149116
120negative regulation of interleukin-12 production (GO:0032695)3.05840062
121DNA replication-independent nucleosome organization (GO:0034724)3.05807528
122DNA replication-independent nucleosome assembly (GO:0006336)3.05807528
123positive regulation of chemokine biosynthetic process (GO:0045080)3.05605657
124regulation of T-helper 1 cell differentiation (GO:0045625)3.04690418
125negative regulation of chromosome segregation (GO:0051985)3.04339394
126negative regulation of cell division (GO:0051782)3.02781840
127regulation of chromatin binding (GO:0035561)2.95086176
128regulation of cytokine secretion involved in immune response (GO:0002739)2.92961541
129response to peptidoglycan (GO:0032494)2.89272392
130phosphatidylinositol dephosphorylation (GO:0046856)2.86922946
131* regulation of reproductive process (GO:2000241)2.84643473
132regulation of interleukin-1 secretion (GO:0050704)2.80286293
133regulation of chemokine biosynthetic process (GO:0045073)2.76435306
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75953787
135positive regulation of histone H3-K4 methylation (GO:0051571)2.75737480
136response to muramyl dipeptide (GO:0032495)2.74769395
137protein dealkylation (GO:0008214)2.74101531
138protein demethylation (GO:0006482)2.74101531
139N-terminal protein amino acid acetylation (GO:0006474)2.73691980
140histone H3-K4 methylation (GO:0051568)2.71433599
141regulation of humoral immune response (GO:0002920)2.68652722
142histone H3-K9 demethylation (GO:0033169)2.67469594
143positive regulation of defense response to virus by host (GO:0002230)2.65800925
144positive regulation of interferon-gamma production (GO:0032729)2.65263573
145type I interferon signaling pathway (GO:0060337)2.64516089
146cellular response to type I interferon (GO:0071357)2.64516089
147regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63272419
148cellular response to arsenic-containing substance (GO:0071243)2.61061969
149phospholipid dephosphorylation (GO:0046839)2.60296823
150response to type I interferon (GO:0034340)2.60080446
151positive regulation of T cell mediated immunity (GO:0002711)2.59721672
152regulation of interferon-alpha production (GO:0032647)2.58710462
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.56542186
154regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54605265
155positive regulation of NF-kappaB import into nucleus (GO:0042346)2.54308034
156regulation of calcium ion import (GO:0090279)2.52749734
157positive regulation of steroid biosynthetic process (GO:0010893)2.52464399
158positive regulation of interleukin-1 beta production (GO:0032731)2.50405049
159myeloid dendritic cell differentiation (GO:0043011)2.50169982
160regulation of gamma-delta T cell activation (GO:0046643)2.49804064
161NIK/NF-kappaB signaling (GO:0038061)2.49782106
162* negative regulation of multi-organism process (GO:0043901)2.48213242
163positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47863620
164embryo implantation (GO:0007566)2.46827246
165negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.41889988
166activation of MAPKKK activity (GO:0000185)2.41532164
167positive regulation of T cell proliferation (GO:0042102)2.40521964
168regulation of podosome assembly (GO:0071801)2.40350414
169regulation of heat generation (GO:0031650)2.39483614
170regulation of female gonad development (GO:2000194)14.4184932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.37154654
2FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.83788479
3AR_21909140_ChIP-Seq_LNCAP_Human3.80902037
4E2F7_22180533_ChIP-Seq_HELA_Human3.78992648
5KAP1_22055183_ChIP-Seq_ESCs_Mouse3.41143212
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.35376073
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.18455725
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09026248
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.99993761
10EZH2_22144423_ChIP-Seq_EOC_Human2.80581652
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78357234
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.70884213
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59279831
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59013881
15MYC_18940864_ChIP-ChIP_HL60_Human2.52381966
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.51867751
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.45199990
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.33527680
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31956766
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.30897946
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.28400527
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28391049
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24231267
24MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.21962789
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.15531981
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00496940
27RUNX1_26923725_Chip-Seq_HPCs_Mouse1.97874149
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95075565
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94961670
30VDR_21846776_ChIP-Seq_THP-1_Human1.85188996
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83926888
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79699430
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79069835
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79069835
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79069835
36RNF2_27304074_Chip-Seq_NSC_Mouse1.76132395
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72794349
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66221977
39VDR_24763502_ChIP-Seq_THP-1_Human1.65580266
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65293818
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64306207
42SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62868140
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.59293855
44GATA3_21867929_ChIP-Seq_TH1_Mouse1.58066908
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56796059
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.52933111
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.51538886
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.49014623
49* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47474147
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47261490
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46345339
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41100246
53GATA1_19941827_ChIP-Seq_MEL86_Mouse1.39281892
54CDX2_22108803_ChIP-Seq_LS180_Human1.39174446
55SPI1_23127762_ChIP-Seq_K562_Human1.39003896
56RUNX_20019798_ChIP-Seq_JUKART_Human1.38358811
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38339731
58* TCF7_22412390_ChIP-Seq_EML_Mouse1.38125400
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36811032
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36490990
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.36473248
62NFYA_21822215_ChIP-Seq_K562_Human1.34891709
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33126820
64LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32076850
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28805163
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28596070
67SCL_19346495_ChIP-Seq_HPC-7_Human1.28485354
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28083706
69VDR_24787735_ChIP-Seq_THP-1_Human1.27490792
70ESET_19884257_ChIP-Seq_ESCs_Mouse1.25754216
71IGF1R_20145208_ChIP-Seq_DFB_Human1.25569901
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24416736
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24172414
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22046333
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21090777
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20731462
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20160544
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19006835
79STAT1_17558387_ChIP-Seq_HELA_Human1.18143430
80KDM2B_26808549_Chip-Seq_DND41_Human1.15959035
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15214077
82GF1B_26923725_Chip-Seq_HPCs_Mouse1.14143876
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13825636
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13223902
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.13102053
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13006864
87HNFA_21074721_ChIP-Seq_CACO-2_Human1.11506985
88ETV1_20927104_ChIP-Seq_GIST48_Human1.11459104
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10045926
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09680684
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09118754
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09044930
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08462086
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08216600
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07998780
96CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07881441
97STAT1_20625510_ChIP-Seq_HELA_Human1.07855168
98NANOG_20526341_ChIP-Seq_ESCs_Human1.06237443
99TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06166686
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05876648
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05720724
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05267206
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04310451
104MYB_26560356_Chip-Seq_TH1_Human1.03856217
105RBPJ_21746931_ChIP-Seq_IB4_Human1.03625557
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03519829
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03150660
108GATA3_26560356_Chip-Seq_TH1_Human1.03005696
109FOXH1_21741376_ChIP-Seq_EPCs_Human1.02735701
110MYB_26560356_Chip-Seq_TH2_Human1.02542699
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02143071
112MYC_22102868_ChIP-Seq_BL_Human1.01307954
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00759844
114SPI1_26923725_Chip-Seq_HPCs_Mouse1.00058940
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99526969
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98920714
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98794630
118GABP_19822575_ChIP-Seq_HepG2_Human0.98628176
119MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98176585
120* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98004619
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97927391
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97794308
123UTX_26944678_Chip-Seq_JUKART_Human0.97224917
124ERG_20517297_ChIP-Seq_VCAP_Human0.96973214
125MAF_26560356_Chip-Seq_TH1_Human0.96950864
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96538321
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95935118
128CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95561130
129SMRT_27268052_Chip-Seq_Bcells_Human0.95302864
130KLF4_19829295_ChIP-Seq_ESCs_Human0.94936070
131GATA6_21074721_ChIP-Seq_CACO-2_Human0.93609544
132TBL1_22424771_ChIP-Seq_293T_Human0.92782433
133OCT4_20526341_ChIP-Seq_ESCs_Human0.91519398
134STAT3_23295773_ChIP-Seq_U87_Human0.91373288
135EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91124995
136* BCOR_27268052_Chip-Seq_Bcells_Human0.90759496
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90528964
138CTCF_18555785_Chip-Seq_ESCs_Mouse0.90501951
139GATA3_27048872_Chip-Seq_THYMUS_Human0.90473232
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90132522
141CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89275754
142VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88947545
143PHF8_20622853_ChIP-Seq_HELA_Human0.88744339
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88236630
145* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88015962
146SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87722917
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87451858
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87343311
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.86850202
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.86434165
151PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85641021
152MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85370730
153SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84996373
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84849733
155OCT4_19829295_ChIP-Seq_ESCs_Human0.84731102
156PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84318041
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.84255466
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83908911
159OCT1_27270436_Chip-Seq_PROSTATE_Human0.83866590
160P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.83249039
161EWS_26573619_Chip-Seq_HEK293_Human0.83151120
162AR_21572438_ChIP-Seq_LNCaP_Human0.82754166
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82164407
164* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81723771
165BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81261733
166CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80996711
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.80450866
168PU_27001747_Chip-Seq_BMDM_Mouse0.80291366
169SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80078307
170TP63_23658742_ChIP-Seq_EP156T_Human0.79819983
171NFE2_27457419_Chip-Seq_LIVER_Mouse0.79802862
172NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.79341475
173FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78987814
174TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78520997
175STAT3_18555785_Chip-Seq_ESCs_Mouse0.78467103
176FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.77767554
177DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77705125
178TFEB_21752829_ChIP-Seq_HELA_Human0.77673736
179TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76828420
180BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.76085314
181* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.76065441
182P68_20966046_ChIP-Seq_HELA_Human0.74194456
183GF1_26923725_Chip-Seq_HPCs_Mouse0.74129280
184KDM2B_26808549_Chip-Seq_K562_Human0.74050969
185SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72881984
186POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.70949652
187TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70949652
188GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67532425
189CTCF_21964334_Chip-Seq_Bcells_Human0.67380883
190GATA2_21666600_ChIP-Seq_HMVEC_Human0.66820199
191MAF_26560356_Chip-Seq_TH2_Human0.64463708
192KDM2B_26808549_Chip-Seq_JURKAT_Human0.62222927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.83463696
2MP0003646_muscle_fatigue6.21470920
3MP0003303_peritoneal_inflammation5.34566294
4MP0005451_abnormal_body_composition5.14167135
5MP0008877_abnormal_DNA_methylation4.05159678
6MP0005395_other_phenotype3.83118251
7MP0003699_abnormal_female_reproductive3.56849000
8MP0002139_abnormal_hepatobiliary_system3.56600896
9MP0003693_abnormal_embryo_hatching3.48457277
10MP0003436_decreased_susceptibility_to3.34954232
11MP0001119_abnormal_female_reproductive3.32531457
12MP0010094_abnormal_chromosome_stability3.28180103
13MP0002148_abnormal_hypersensitivity_rea2.71481453
14MP0003077_abnormal_cell_cycle2.71454615
15MP0002138_abnormal_hepatobiliary_system2.69900666
16MP0001929_abnormal_gametogenesis2.67817711
17MP0003111_abnormal_nucleus_morphology2.60091603
18MP0003724_increased_susceptibility_to2.50086735
19MP0003315_abnormal_perineum_morphology2.48740598
20MP0006082_CNS_inflammation2.48363776
21MP0000653_abnormal_sex_gland2.44704913
22MP0009278_abnormal_bone_marrow2.42309679
23MP0004957_abnormal_blastocyst_morpholog2.39945490
24MP0009785_altered_susceptibility_to2.39837570
25MP0005000_abnormal_immune_tolerance2.29628377
26MP0005646_abnormal_pituitary_gland2.25929448
27MP0000579_abnormal_nail_morphology2.22772233
28MP0002210_abnormal_sex_determination2.16749095
29MP0001545_abnormal_hematopoietic_system2.15528018
30MP0005397_hematopoietic_system_phenotyp2.15528018
31MP0002653_abnormal_ependyma_morphology2.08994559
32MP0002102_abnormal_ear_morphology2.08803624
33MP0005187_abnormal_penis_morphology2.05733314
34MP0005387_immune_system_phenotype2.02844754
35MP0001790_abnormal_immune_system2.02844754
36MP0002295_abnormal_pulmonary_circulatio1.97710714
37MP0001835_abnormal_antigen_presentation1.97340420
38MP0005671_abnormal_response_to1.93035306
39MP0005025_abnormal_response_to1.91303133
40MP0010307_abnormal_tumor_latency1.89386796
41MP0008004_abnormal_stomach_pH1.89159764
42MP0002419_abnormal_innate_immunity1.88235913
43MP0002161_abnormal_fertility/fecundity1.83680569
44MP0004947_skin_inflammation1.78208290
45MP0002723_abnormal_immune_serum1.75254087
46MP0001800_abnormal_humoral_immune1.72251658
47MP0002452_abnormal_antigen_presenting1.68041706
48MP0005257_abnormal_intraocular_pressure1.66827437
49MP0005058_abnormal_lysosome_morphology1.60642667
50MP0003121_genomic_imprinting1.53689889
51MP0008932_abnormal_embryonic_tissue1.52662343
52MP0003937_abnormal_limbs/digits/tail_de1.52249439
53MP0009764_decreased_sensitivity_to1.51729436
54MP0005076_abnormal_cell_differentiation1.51079024
55MP0003300_gastrointestinal_ulcer1.50685133
56MP0001533_abnormal_skeleton_physiology1.50394523
57MP0003950_abnormal_plasma_membrane1.49431538
58MP0010155_abnormal_intestine_physiology1.48870890
59MP0000685_abnormal_immune_system1.47472635
60MP0005408_hypopigmentation1.44511359
61MP0002420_abnormal_adaptive_immunity1.42971863
62MP0008057_abnormal_DNA_replication1.42487216
63MP0001819_abnormal_immune_cell1.41718116
64MP0000604_amyloidosis1.35891851
65MP0004859_abnormal_synaptic_plasticity1.35252590
66MP0009840_abnormal_foam_cell1.35001885
67MP0002249_abnormal_larynx_morphology1.31643933
68MP0005360_urolithiasis1.31345309
69MP0008469_abnormal_protein_level1.30221591
70MP0001145_abnormal_male_reproductive1.29505184
71MP0001905_abnormal_dopamine_level1.26633301
72MP0006292_abnormal_olfactory_placode1.26489776
73MP0004264_abnormal_extraembryonic_tissu1.26407090
74MP0001919_abnormal_reproductive_system1.26113943
75MP0003879_abnormal_hair_cell1.23176003
76MP0001730_embryonic_growth_arrest1.22412877
77MP0001529_abnormal_vocalization1.22350427
78MP0006072_abnormal_retinal_apoptosis1.21856843
79MP0009333_abnormal_splenocyte_physiolog1.21063598
80MP0005410_abnormal_fertilization1.20948122
81MP0002405_respiratory_system_inflammati1.20384777
82MP0000350_abnormal_cell_proliferation1.20349902
83MP0008260_abnormal_autophagy1.19253434
84MP0003075_altered_response_to1.15868733
85MP0004510_myositis1.13905402
86MP0003183_abnormal_peptide_metabolism1.13611648
87MP0003195_calcinosis1.12745552
88MP0001915_intracranial_hemorrhage1.11906775
89MP0003091_abnormal_cell_migration1.11614488
90MP0001845_abnormal_inflammatory_respons1.11446299
91MP0003448_altered_tumor_morphology1.11428516
92MP0001853_heart_inflammation1.10736943
93MP0005310_abnormal_salivary_gland1.10088323
94MP0003787_abnormal_imprinting1.09708251
95MP0009384_cardiac_valve_regurgitation1.09144855
96MP0002398_abnormal_bone_marrow1.08732063
97MP0002998_abnormal_bone_remodeling1.07311612
98MP0000716_abnormal_immune_system1.07152479
99MP0005389_reproductive_system_phenotype1.06496776
100MP0005394_taste/olfaction_phenotype1.04002797
101MP0005499_abnormal_olfactory_system1.04002797
102MP0002019_abnormal_tumor_incidence0.99581668
103MP0008789_abnormal_olfactory_epithelium0.99385832
104MP0002085_abnormal_embryonic_tissue0.99074578
105MP0005166_decreased_susceptibility_to0.98780227
106MP0002254_reproductive_system_inflammat0.97828239
107MP0005167_abnormal_blood-brain_barrier0.95920357
108MP0002932_abnormal_joint_morphology0.95563379
109MP0004808_abnormal_hematopoietic_stem0.95025737
110MP0003453_abnormal_keratinocyte_physiol0.92156747
111MP0009697_abnormal_copulation0.91077440
112MP0004185_abnormal_adipocyte_glucose0.90607544
113MP0003690_abnormal_glial_cell0.90298062
114MP0005380_embryogenesis_phenotype0.89907302
115MP0001672_abnormal_embryogenesis/_devel0.89907302
116MP0003123_paternal_imprinting0.89004521
117MP0003705_abnormal_hypodermis_morpholog0.86394726
118MP0010368_abnormal_lymphatic_system0.85751170
119MP0000733_abnormal_muscle_development0.84445402
120MP0002722_abnormal_immune_system0.82708233
121MP0003959_abnormal_lean_body0.81788749
122MP0000465_gastrointestinal_hemorrhage0.81730970
123MP0001346_abnormal_lacrimal_gland0.80740721
124MP0002282_abnormal_trachea_morphology0.79821936
125MP0000678_abnormal_parathyroid_gland0.78433294
126MP0001501_abnormal_sleep_pattern0.77499202
127MP0000613_abnormal_salivary_gland0.76594030
128MP0002429_abnormal_blood_cell0.75625884
129MP0002089_abnormal_postnatal_growth/wei0.75338403
130MP0000639_abnormal_adrenal_gland0.75072656
131MP0000689_abnormal_spleen_morphology0.74147676
132MP0002084_abnormal_developmental_patter0.73599266
133MP0001697_abnormal_embryo_size0.72209215
134MP0010352_gastrointestinal_tract_polyps0.71686048
135MP0000343_altered_response_to0.69305026
136MP0000427_abnormal_hair_cycle0.65157651
137MP0003890_abnormal_embryonic-extraembry0.65154284
138MP0005647_abnormal_sex_gland0.65151842
139MP0000858_altered_metastatic_potential0.64752375
140MP0010386_abnormal_urinary_bladder0.62987124
141MP0005164_abnormal_response_to0.62109889
142MP0002269_muscular_atrophy0.61860852
143MP0008874_decreased_physiological_sensi0.61774377
144MP0003868_abnormal_feces_composition0.61728536
145MP0003763_abnormal_thymus_physiology0.60695695
146MP0003656_abnormal_erythrocyte_physiolo0.59321345
147MP0008007_abnormal_cellular_replicative0.59192658
148MP0005621_abnormal_cell_physiology0.59009063
149MP0001485_abnormal_pinna_reflex0.57176976
150MP0003698_abnormal_male_reproductive0.57158761
151MP0008875_abnormal_xenobiotic_pharmacok0.56142075
152MP0002332_abnormal_exercise_endurance0.55529455
153MP0005197_abnormal_uvea_morphology0.55176221
154MP0002177_abnormal_outer_ear0.55041777
155MP0001849_ear_inflammation0.52162373
156MP0000490_abnormal_crypts_of0.51354677
157MP0010234_abnormal_vibrissa_follicle0.49140010
158MP0003329_amyloid_beta_deposits0.47606944
159MP0004036_abnormal_muscle_relaxation0.47040993
160MP0002080_prenatal_lethality0.45829664
161MP0005023_abnormal_wound_healing0.44505342
162MP0000462_abnormal_digestive_system0.44231982
163MP0003755_abnormal_palate_morphology0.42650573
164MP0004145_abnormal_muscle_electrophysio0.41218405
165MP0005384_cellular_phenotype0.40489349
166MP0003942_abnormal_urinary_system0.37884631
167MP0002127_abnormal_cardiovascular_syste0.37592626
168MP0000313_abnormal_cell_death0.37153431
169MP0004484_altered_response_of0.36494414
170MP0008058_abnormal_DNA_repair0.36404836
171MP0004782_abnormal_surfactant_physiolog0.34417953
172MP0002168_other_aberrant_phenotype0.33811682
173MP0003861_abnormal_nervous_system0.31822785

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.46544817
2Premature ovarian failure (HP:0008209)6.45007602
3Infertility (HP:0000789)6.09220807
4Cortical dysplasia (HP:0002539)5.72962685
5Cholecystitis (HP:0001082)5.47006334
6Abnormal gallbladder physiology (HP:0012438)5.47006334
7Deep venous thrombosis (HP:0002625)5.16615692
8Diminished motivation (HP:0000745)4.81723782
9Loss of speech (HP:0002371)4.80109254
10Secondary amenorrhea (HP:0000869)4.63976387
11Birth length less than 3rd percentile (HP:0003561)4.55203919
12Stomatitis (HP:0010280)4.48156281
13Breast hypoplasia (HP:0003187)4.46297481
14Chromsome breakage (HP:0040012)4.14582026
15Abnormality of macrophages (HP:0004311)4.12219963
16Abnormality of glycolipid metabolism (HP:0010969)3.99107958
17Abnormality of liposaccharide metabolism (HP:0010968)3.99107958
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.99107958
19Retrobulbar optic neuritis (HP:0100654)3.94556412
20Optic neuritis (HP:0100653)3.94556412
21Rhabdomyosarcoma (HP:0002859)3.87018045
22Atelectasis (HP:0100750)3.83292647
23Hypergonadotropic hypogonadism (HP:0000815)3.76764453
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68791616
25Flat capital femoral epiphysis (HP:0003370)3.68638568
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.67831769
27Pulmonary fibrosis (HP:0002206)3.60595468
28Neurofibrillary tangles (HP:0002185)3.60028179
29Orchitis (HP:0100796)3.54495859
30Adrenal hypoplasia (HP:0000835)3.51855052
31Combined immunodeficiency (HP:0005387)3.49580612
32Mutism (HP:0002300)3.42705376
33Aplasia/Hypoplasia of the macula (HP:0008059)3.34298735
34Myositis (HP:0100614)3.33824457
35Patellar aplasia (HP:0006443)3.28246087
36Anosmia (HP:0000458)3.25237897
37Abnormality of the labia minora (HP:0012880)3.19990846
38Aplasia/Hypoplasia of the breasts (HP:0010311)3.18575774
39Nuclear cataract (HP:0100018)3.18421780
40Autoimmune thrombocytopenia (HP:0001973)3.17341268
41Supranuclear gaze palsy (HP:0000605)3.14023293
42Breast aplasia (HP:0100783)3.12013442
43Aplasia/Hypoplasia affecting the retina (HP:0008061)3.06022012
44Obstructive sleep apnea (HP:0002870)3.04455398
45Recurrent bacterial skin infections (HP:0005406)2.98663717
46Abnormality of chromosome segregation (HP:0002916)2.98503014
47Aplasia/Hypoplasia of the patella (HP:0006498)2.97471386
48Aplasia/Hypoplasia of the sternum (HP:0006714)2.95326386
49Papillary thyroid carcinoma (HP:0002895)2.90387744
50Metaphyseal irregularity (HP:0003025)2.89082896
51Shawl scrotum (HP:0000049)2.87804504
52Anhidrosis (HP:0000970)2.84698971
53Insulin-resistant diabetes mellitus (HP:0000831)2.82996677
54Abnormality of placental membranes (HP:0011409)2.79504873
55Amniotic constriction ring (HP:0009775)2.79504873
56Abnormality of the fovea (HP:0000493)2.77729829
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76989185
58Lip pit (HP:0100267)2.75858990
59Neuronal loss in central nervous system (HP:0002529)2.73951358
60Disinhibition (HP:0000734)2.72981067
61Arterial tortuosity (HP:0005116)2.72785379
62Neoplasm of striated muscle (HP:0009728)2.72293010
63Primary amenorrhea (HP:0000786)2.66722298
64Malnutrition (HP:0004395)2.66339394
65Prolonged neonatal jaundice (HP:0006579)2.61899593
66Abnormality of the proximal phalanges of the hand (HP:0009834)2.61398111
67Impulsivity (HP:0100710)2.59945156
68Cone-rod dystrophy (HP:0000548)2.57644690
69Hypogonadotrophic hypogonadism (HP:0000044)2.56496954
70Progressive sensorineural hearing impairment (HP:0000408)2.53029536
71Aplasia/Hypoplasia involving the musculature (HP:0001460)2.51720601
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.50975680
73Hypoplasia of the fovea (HP:0007750)2.50975680
74Keratoconjunctivitis sicca (HP:0001097)2.49362267
75Fetal akinesia sequence (HP:0001989)2.47689022
76Recurrent abscess formation (HP:0002722)2.43646003
77Abdominal situs inversus (HP:0003363)2.42626362
78Abnormality of abdominal situs (HP:0011620)2.42626362
79Mediastinal lymphadenopathy (HP:0100721)2.39324174
80Vacuolated lymphocytes (HP:0001922)2.38453931
81Vasculitis (HP:0002633)2.38272843
82Fibular aplasia (HP:0002990)2.38012956
83Vascular tortuosity (HP:0004948)2.35820725
84Anterior segment dysgenesis (HP:0007700)2.34787448
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34020502
86Small intestinal stenosis (HP:0012848)2.33531144
87Duodenal stenosis (HP:0100867)2.33531144
88Supernumerary spleens (HP:0009799)2.28996909
89Absent hand (HP:0004050)2.28570876
90Abnormal lung lobation (HP:0002101)2.26965130
91Sandal gap (HP:0001852)2.26657289
92Dysostosis multiplex (HP:0000943)2.26495595
93Facial hemangioma (HP:0000329)2.26383988
94Gastrointestinal stroma tumor (HP:0100723)2.25243063
95Oral leukoplakia (HP:0002745)2.23209804
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23042052
97Keratoconjunctivitis (HP:0001096)2.22871025
98Cerebral inclusion bodies (HP:0100314)2.22615956
99Memory impairment (HP:0002354)2.21553777
100Nonprogressive disorder (HP:0003680)2.20114315
101Systemic lupus erythematosus (HP:0002725)2.17436297
102Carpal bone hypoplasia (HP:0001498)2.15655754
103Eczematoid dermatitis (HP:0000976)2.15585279
104IgA deficiency (HP:0002720)2.15035760
105Aplasia of the musculature (HP:0100854)2.13409589
106Chronic bronchitis (HP:0004469)2.12951118
107Short 1st metacarpal (HP:0010034)2.12850656
108Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.12850656
109Sloping forehead (HP:0000340)2.12238318
110Delayed puberty (HP:0000823)2.11716085
111Nephroblastoma (Wilms tumor) (HP:0002667)2.09117442
112Pulmonary infiltrates (HP:0002113)2.08110372
113Abnormality of the anterior chamber (HP:0000593)2.08011994
114Overlapping toe (HP:0001845)2.06072750
115Abnormality of chromosome stability (HP:0003220)2.05876047
116Oligodactyly (hands) (HP:0001180)2.05004603
117Hypercortisolism (HP:0001578)2.03208290
118Aplasia involving forearm bones (HP:0009822)2.02803723
119Absent forearm bone (HP:0003953)2.02803723
120Increased IgM level (HP:0003496)2.01797668
121Abnormality of alanine metabolism (HP:0010916)2.00905456
122Hyperalaninemia (HP:0003348)2.00905456
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00905456
124Gangrene (HP:0100758)2.00902527
125Hypophosphatemic rickets (HP:0004912)2.00730315
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99738502
127Parakeratosis (HP:0001036)1.99666682
128Azoospermia (HP:0000027)1.99324574
129Absent radius (HP:0003974)1.98609764
130Aplastic anemia (HP:0001915)1.97462407
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97378345
132Osteomyelitis (HP:0002754)1.96328881
133Subcapsular cataract (HP:0000523)1.95846081
134Lower limb hyperreflexia (HP:0002395)1.94544813
135Myokymia (HP:0002411)1.94474568
136Bronchiectasis (HP:0002110)1.92414067
137Villous atrophy (HP:0011473)1.92286289
138Abnormality of small intestinal villus morphology (HP:0011472)1.92286289
139Capillary hemangiomas (HP:0005306)1.92110492
140Hematochezia (HP:0002573)1.92105072
141Embryonal renal neoplasm (HP:0011794)1.91507040
142Polyneuropathy (HP:0001271)1.90802295
143Leiomyosarcoma (HP:0100243)1.90315891
144Uterine leiomyosarcoma (HP:0002891)1.90315891
145Hemoptysis (HP:0002105)1.89771483
146Abnormality of cochlea (HP:0000375)1.89751813
147Abnormality of the epiphysis of the femoral head (HP:0010574)1.87720158
148Spondylolisthesis (HP:0003302)1.85404142
149Abnormality of polysaccharide metabolism (HP:0011012)1.85103155
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85103155
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85103155
152Truncal obesity (HP:0001956)1.84624419
153Nausea (HP:0002018)1.84309162
154Elevated erythrocyte sedimentation rate (HP:0003565)1.82889017
155Osteomalacia (HP:0002749)1.82377367
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.81801264
157Aplasia involving bones of the upper limbs (HP:0009823)1.81533737
158Aplasia of the phalanges of the hand (HP:0009802)1.81533737
159Aplasia involving bones of the extremities (HP:0009825)1.81533737
160Dementia (HP:0000726)1.78868429
161Abnormality of the 1st metacarpal (HP:0010009)1.78757325
162Apathy (HP:0000741)1.78483233
163Abnormality of the femoral head (HP:0003368)1.75727123
164Posterior embryotoxon (HP:0000627)1.74650267
165Acute myeloid leukemia (HP:0004808)1.74554981
166Arachnodactyly (HP:0001166)1.74244924
167Inappropriate behavior (HP:0000719)1.72883333
168Amyloidosis (HP:0011034)1.72819480
169Abnormality of the duodenum (HP:0002246)1.72626991
170Molar tooth sign on MRI (HP:0002419)1.72303989
171Abnormality of midbrain morphology (HP:0002418)1.72303989
172Mucopolysacchariduria (HP:0008155)1.68185305
173Urinary glycosaminoglycan excretion (HP:0003541)1.68185305
174Intrahepatic cholestasis (HP:0001406)1.66537583
175Increased serum ferritin (HP:0003281)1.65922752
176Increased cerebral lipofuscin (HP:0011813)1.65163083
177Progressive hearing impairment (HP:0001730)1.62244306
178Recurrent viral infections (HP:0004429)1.61681621
179Psychosis (HP:0000709)1.60647071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR26.31729989
2MOS5.99693016
3CDK125.98032294
4TAOK34.88758992
5MAP3K64.50367566
6IRAK33.90580833
7TTK3.56991422
8LATS13.02945719
9CAMK1D3.01754020
10LATS22.90632612
11KSR22.77981203
12ERBB42.77533069
13TAOK22.75735926
14PRPF4B2.71049039
15MAP3K142.70492454
16STK102.57208100
17PLK42.46683111
18RIPK12.38572359
19MAP3K92.30638626
20BRAF2.19499065
21EEF2K2.03803653
22PRKD31.99621929
23ERN11.97829649
24IKBKB1.95525826
25STK38L1.94177900
26TBK11.93869364
27BRD41.91395630
28CDK81.85932219
29MAP3K131.84278080
30CAMK1G1.82631161
31IKBKE1.82352803
32MAP4K11.78399906
33CDC42BPA1.75010820
34MATK1.69662539
35CDC71.67227150
36ZAP701.67055167
37BUB11.62531347
38CHUK1.61978004
39MELK1.61706728
40ARAF1.58709908
41MUSK1.56437120
42IRAK41.54938106
43TAOK11.53394088
44GRK71.43432628
45CHEK21.37461182
46NEK21.31743271
47TXK1.30955986
48PLK11.28267253
49PIM21.28194141
50MAP3K81.26103532
51NEK61.23990672
52DDR21.22973324
53STK31.20027857
54RAF11.17539890
55DYRK21.17368474
56MAPKAPK31.17129994
57MAP3K31.13766269
58JAK31.12413858
59IRAK21.11859153
60RIPK41.11629712
61CDK91.11001166
62ICK1.09609280
63MARK31.03459128
64TYK21.02052481
65PIM11.01354946
66MAP3K40.96931827
67MAPK130.96476517
68CSNK1G10.94357378
69IRAK10.94313727
70PAK60.94110919
71RET0.92705871
72BLK0.89382122
73AURKA0.85430652
74MTOR0.85327041
75MAPKAPK50.84695959
76NME20.83840286
77CSK0.83189684
78SIK20.82716467
79CLK10.81649974
80MAP3K110.79429197
81CSNK1G30.74881370
82MAP2K30.74023310
83PRKD20.73461108
84TGFBR20.73270533
85AURKB0.69846817
86TESK20.68910164
87MAP2K70.68620485
88WNK10.68521944
89CSNK1G20.68341198
90NLK0.68195022
91KSR10.66807428
92FGR0.64831952
93SYK0.62659203
94CSNK1A1L0.60746300
95CAMK40.59944740
96CSF1R0.59520307
97PINK10.59254322
98ABL20.56478835
99EIF2AK10.54358891
100LYN0.52670950
101PKN10.51466115
102TNK20.50700231
103TGFBR10.49616178
104MET0.48717230
105LCK0.48337193
106STK380.48019687
107PRKAA10.45252466
108DMPK0.42967753
109PDK10.42723757
110LRRK20.42608973
111TNIK0.42065598
112MAPK70.39303969
113ACVR1B0.37192704
114CDK40.36462948
115NEK10.36118660
116MAP3K20.36046160
117MAP2K40.35891620
118PRKCZ0.34912701
119PRKCI0.34760371
120TYRO30.34480534
121PLK30.33013878
122PRKAA20.32191746
123MAPK110.31907504
124HCK0.30755252
125STK240.29979570
126MAP3K10.29552642
127MAPK100.29411998
128TRIM280.29272626
129RPS6KB20.28747015
130SGK2230.28396245
131SGK4940.28396245
132RPS6KA10.27083686
133JAK10.26944239
134ATM0.26067121
135TRPM70.25753173
136KIT0.25475134
137CSNK1D0.25420537
138MAP3K50.24779691
139INSR0.24703475
140CHEK10.24553911
141CDK10.24032731
142ABL10.22913227
143PLK20.21842714
144SGK20.21755195
145CDK70.20920128
146EPHA40.19926146
147MARK20.19816039
148HIPK20.19410232
149EPHA30.17546655
150MAP2K10.16295180
151CDK20.16067100
152CAMK2A0.14230585
153PAK10.14117928
154NTRK20.13820598
155ROCK10.09459314
156AKT10.08786567
157CSNK1A10.07658913
158MAPK10.07004597
159VRK10.06364227
160STK110.05876493
161MAP2K20.04958330
162JAK20.04916479
163TRIB30.04663106
164ROCK20.04566733
165ADRBK10.04051007

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.43283486
2Cell cycle_Homo sapiens_hsa041103.74779391
3Basal transcription factors_Homo sapiens_hsa030223.51635755
4RNA degradation_Homo sapiens_hsa030183.43593509
5Oocyte meiosis_Homo sapiens_hsa041143.17519113
6Vitamin B6 metabolism_Homo sapiens_hsa007503.07563421
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73897509
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.63490453
9Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.59991220
10Circadian rhythm_Homo sapiens_hsa047102.58279141
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51436990
12Osteoclast differentiation_Homo sapiens_hsa043802.45948463
13Linoleic acid metabolism_Homo sapiens_hsa005912.43623156
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.41021419
15TNF signaling pathway_Homo sapiens_hsa046682.33669358
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22394238
17Influenza A_Homo sapiens_hsa051642.21532888
18Allograft rejection_Homo sapiens_hsa053302.16086123
19Ether lipid metabolism_Homo sapiens_hsa005652.13352284
20Fanconi anemia pathway_Homo sapiens_hsa034602.07779622
21Asthma_Homo sapiens_hsa053102.05533888
22Homologous recombination_Homo sapiens_hsa034402.04590176
23Leishmaniasis_Homo sapiens_hsa051402.04588098
24Intestinal immune network for IgA production_Homo sapiens_hsa046722.00769914
25GnRH signaling pathway_Homo sapiens_hsa049121.98803979
26Rheumatoid arthritis_Homo sapiens_hsa053231.98392560
27Pancreatic cancer_Homo sapiens_hsa052121.97237809
28Dorso-ventral axis formation_Homo sapiens_hsa043201.96526956
29Base excision repair_Homo sapiens_hsa034101.95081383
30Graft-versus-host disease_Homo sapiens_hsa053321.94468565
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93667390
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91470716
33RNA transport_Homo sapiens_hsa030131.89199990
34Herpes simplex infection_Homo sapiens_hsa051681.78819178
35RNA polymerase_Homo sapiens_hsa030201.78447928
36Malaria_Homo sapiens_hsa051441.77684580
37African trypanosomiasis_Homo sapiens_hsa051431.73649881
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73320131
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72979342
40Legionellosis_Homo sapiens_hsa051341.69608756
41Non-homologous end-joining_Homo sapiens_hsa034501.66554555
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63046247
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.59659341
44Autoimmune thyroid disease_Homo sapiens_hsa053201.55271655
45Staphylococcus aureus infection_Homo sapiens_hsa051501.52589340
46Tuberculosis_Homo sapiens_hsa051521.51873461
47Pertussis_Homo sapiens_hsa051331.51515168
48MicroRNAs in cancer_Homo sapiens_hsa052061.45781865
49Toxoplasmosis_Homo sapiens_hsa051451.42333693
50mRNA surveillance pathway_Homo sapiens_hsa030151.41831617
51Type I diabetes mellitus_Homo sapiens_hsa049401.40005335
52B cell receptor signaling pathway_Homo sapiens_hsa046621.35885609
53Measles_Homo sapiens_hsa051621.35154906
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.34842719
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28308544
56TGF-beta signaling pathway_Homo sapiens_hsa043501.27002626
57Glycerophospholipid metabolism_Homo sapiens_hsa005641.25308345
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24911542
59DNA replication_Homo sapiens_hsa030301.23198952
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22365276
61p53 signaling pathway_Homo sapiens_hsa041151.20689659
62Hematopoietic cell lineage_Homo sapiens_hsa046401.20593374
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18437858
64Folate biosynthesis_Homo sapiens_hsa007901.16037265
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.15703802
66Colorectal cancer_Homo sapiens_hsa052101.15588010
67Lysosome_Homo sapiens_hsa041421.15070926
68T cell receptor signaling pathway_Homo sapiens_hsa046601.14663420
69VEGF signaling pathway_Homo sapiens_hsa043701.13301019
70Choline metabolism in cancer_Homo sapiens_hsa052311.13236059
71Hepatitis C_Homo sapiens_hsa051601.13040479
72Acute myeloid leukemia_Homo sapiens_hsa052211.09659038
73mTOR signaling pathway_Homo sapiens_hsa041501.08696601
74Long-term depression_Homo sapiens_hsa047301.08365938
75Prion diseases_Homo sapiens_hsa050201.06921098
76Prolactin signaling pathway_Homo sapiens_hsa049171.06515121
77Salmonella infection_Homo sapiens_hsa051321.04527401
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03553136
79Phagosome_Homo sapiens_hsa041451.03232617
80Nucleotide excision repair_Homo sapiens_hsa034200.99691365
81Chemokine signaling pathway_Homo sapiens_hsa040620.98718826
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95634150
83Amoebiasis_Homo sapiens_hsa051460.94689791
84Epstein-Barr virus infection_Homo sapiens_hsa051690.93748374
85Primary immunodeficiency_Homo sapiens_hsa053400.87849466
86Viral myocarditis_Homo sapiens_hsa054160.80896702
87Mismatch repair_Homo sapiens_hsa034300.79258411
88HIF-1 signaling pathway_Homo sapiens_hsa040660.77424768
89Notch signaling pathway_Homo sapiens_hsa043300.76994979
90Renal cell carcinoma_Homo sapiens_hsa052110.75847265
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70926968
92Bladder cancer_Homo sapiens_hsa052190.69308616
93Lysine degradation_Homo sapiens_hsa003100.68969683
94Ras signaling pathway_Homo sapiens_hsa040140.68731204
95Antigen processing and presentation_Homo sapiens_hsa046120.68370921
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.67936582
97Inositol phosphate metabolism_Homo sapiens_hsa005620.67545263
98Hippo signaling pathway_Homo sapiens_hsa043900.67184005
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.65776857
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65626813
101FoxO signaling pathway_Homo sapiens_hsa040680.65462685
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64377657
103Type II diabetes mellitus_Homo sapiens_hsa049300.63369412
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.62114205
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62038521
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61383176
107Adherens junction_Homo sapiens_hsa045200.61119225
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61087310
109Purine metabolism_Homo sapiens_hsa002300.59330989
110Viral carcinogenesis_Homo sapiens_hsa052030.57874573
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56636660
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56057224
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54673382
114HTLV-I infection_Homo sapiens_hsa051660.53674410
115Chronic myeloid leukemia_Homo sapiens_hsa052200.52028466
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51569386
117Endometrial cancer_Homo sapiens_hsa052130.51349907
118Regulation of autophagy_Homo sapiens_hsa041400.50549011
119Thyroid cancer_Homo sapiens_hsa052160.49302392
120Pyrimidine metabolism_Homo sapiens_hsa002400.49093034
121Arachidonic acid metabolism_Homo sapiens_hsa005900.47863939
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47713519
123MAPK signaling pathway_Homo sapiens_hsa040100.47688680
124Non-small cell lung cancer_Homo sapiens_hsa052230.47293635
125Estrogen signaling pathway_Homo sapiens_hsa049150.46509458
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45314397
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43375958
128Gap junction_Homo sapiens_hsa045400.43270817
129Glutamatergic synapse_Homo sapiens_hsa047240.42551052
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37157789
131Small cell lung cancer_Homo sapiens_hsa052220.35966911
132Insulin resistance_Homo sapiens_hsa049310.34763094
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34747181
134Melanoma_Homo sapiens_hsa052180.33592514
135Serotonergic synapse_Homo sapiens_hsa047260.33110379
136Shigellosis_Homo sapiens_hsa051310.31952510
137ABC transporters_Homo sapiens_hsa020100.30703476
138Endocytosis_Homo sapiens_hsa041440.30239033
139Glioma_Homo sapiens_hsa052140.29713697
140Hepatitis B_Homo sapiens_hsa051610.29377011
141Pyruvate metabolism_Homo sapiens_hsa006200.28250808
142Arginine and proline metabolism_Homo sapiens_hsa003300.27402549
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.26956406
144Other glycan degradation_Homo sapiens_hsa005110.24414843
145Complement and coagulation cascades_Homo sapiens_hsa046100.22796353
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.22470019
147Sphingolipid metabolism_Homo sapiens_hsa006000.20895444
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20055784
149Histidine metabolism_Homo sapiens_hsa003400.19668142
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19636189
151Arginine biosynthesis_Homo sapiens_hsa002200.19106601
152Oxytocin signaling pathway_Homo sapiens_hsa049210.18889611
153Prostate cancer_Homo sapiens_hsa052150.17953059
154Apoptosis_Homo sapiens_hsa042100.16907019
155ErbB signaling pathway_Homo sapiens_hsa040120.13535713
156Wnt signaling pathway_Homo sapiens_hsa043100.12944977
157beta-Alanine metabolism_Homo sapiens_hsa004100.10530319
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09150962
159Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08352777

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »