ASTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04608353
2vocalization behavior (GO:0071625)5.77064198
3locomotory exploration behavior (GO:0035641)5.66121051
4synaptic vesicle maturation (GO:0016188)5.57689857
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51776241
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40836052
7synaptic vesicle exocytosis (GO:0016079)5.21783356
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.18289041
9regulation of glutamate receptor signaling pathway (GO:1900449)5.03226482
10glutamate secretion (GO:0014047)4.99961580
11* neuron cell-cell adhesion (GO:0007158)4.94175856
12protein localization to synapse (GO:0035418)4.92614741
13regulation of synaptic vesicle exocytosis (GO:2000300)4.83033073
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.81756813
15layer formation in cerebral cortex (GO:0021819)4.64242282
16exploration behavior (GO:0035640)4.62299758
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.52201545
18regulation of neuronal synaptic plasticity (GO:0048168)4.41550062
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39649413
20dendritic spine morphogenesis (GO:0060997)4.36654184
21neurotransmitter secretion (GO:0007269)4.36120981
22neurotransmitter-gated ion channel clustering (GO:0072578)4.34187553
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32135703
24glutamate receptor signaling pathway (GO:0007215)4.30333617
25neuron recognition (GO:0008038)4.29739317
26regulation of synapse structural plasticity (GO:0051823)4.28819786
27regulation of synaptic vesicle transport (GO:1902803)4.27289381
28synaptic transmission, glutamatergic (GO:0035249)4.26927487
29axonal fasciculation (GO:0007413)4.19085782
30gamma-aminobutyric acid transport (GO:0015812)4.16885202
31neuronal action potential propagation (GO:0019227)4.10816383
32proline transport (GO:0015824)4.04151284
33neuron-neuron synaptic transmission (GO:0007270)4.00341043
34L-amino acid import (GO:0043092)3.86875526
35postsynaptic membrane organization (GO:0001941)3.86560742
36atrial cardiac muscle cell action potential (GO:0086014)3.86290661
37cerebellar granule cell differentiation (GO:0021707)3.84087119
38long-term memory (GO:0007616)3.73906914
39positive regulation of dendritic spine morphogenesis (GO:0061003)3.73797502
40regulation of synapse maturation (GO:0090128)3.73264124
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70731605
42C4-dicarboxylate transport (GO:0015740)3.69561574
43mechanosensory behavior (GO:0007638)3.68806833
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68360108
45pyrimidine nucleobase catabolic process (GO:0006208)3.67658601
46positive regulation of membrane potential (GO:0045838)3.65769674
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64439005
48cellular potassium ion homeostasis (GO:0030007)3.62874987
49positive regulation of synapse maturation (GO:0090129)3.61761786
50neurotransmitter transport (GO:0006836)3.59040449
51regulation of postsynaptic membrane potential (GO:0060078)3.56609450
52potassium ion homeostasis (GO:0055075)3.56243449
53dendrite morphogenesis (GO:0048813)3.55848716
54presynaptic membrane assembly (GO:0097105)3.53642632
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52876125
56presynaptic membrane organization (GO:0097090)3.50923140
57transmission of nerve impulse (GO:0019226)3.49468208
58synaptic vesicle endocytosis (GO:0048488)3.48598042
59axon ensheathment in central nervous system (GO:0032291)3.48205927
60central nervous system myelination (GO:0022010)3.48205927
61regulation of dendritic spine morphogenesis (GO:0061001)3.47630807
62regulation of synaptic plasticity (GO:0048167)3.46111145
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.44449235
64amino acid import (GO:0043090)3.42264198
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.41897497
66auditory behavior (GO:0031223)3.41844548
67response to auditory stimulus (GO:0010996)3.40983775
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.39087314
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39061156
70sodium ion export (GO:0071436)3.38460525
71regulation of neurotransmitter levels (GO:0001505)3.33659124
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32260116
73cerebellar Purkinje cell differentiation (GO:0021702)3.30719737
74regulation of neurotransmitter secretion (GO:0046928)3.30659882
75activation of protein kinase A activity (GO:0034199)3.30473132
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29717295
77central nervous system projection neuron axonogenesis (GO:0021952)3.28173653
78innervation (GO:0060384)3.27831902
79neuronal ion channel clustering (GO:0045161)3.27723262
80cerebral cortex radially oriented cell migration (GO:0021799)3.27511968
81long-term synaptic potentiation (GO:0060291)3.27016945
82prepulse inhibition (GO:0060134)3.26944249
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.26663691
84cell migration in hindbrain (GO:0021535)3.26017857
85synapse assembly (GO:0007416)3.24774359
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22944305
87neuromuscular process controlling balance (GO:0050885)3.21926382
88potassium ion import (GO:0010107)3.20263541
89response to histamine (GO:0034776)3.19773660
90cellular sodium ion homeostasis (GO:0006883)3.18384799
91cell communication by electrical coupling (GO:0010644)3.17718021
92regulation of vesicle fusion (GO:0031338)3.14628318
93learning (GO:0007612)3.14227228
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11811102
95cell communication involved in cardiac conduction (GO:0086065)3.09997532
96behavioral fear response (GO:0001662)3.09301647
97behavioral defense response (GO:0002209)3.09301647
98establishment of mitochondrion localization (GO:0051654)3.08960989
99acidic amino acid transport (GO:0015800)3.07334426
100regulation of neurotransmitter transport (GO:0051588)3.06218104
101membrane depolarization (GO:0051899)3.05594657
102social behavior (GO:0035176)3.04826360
103intraspecies interaction between organisms (GO:0051703)3.04826360
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04064623
105membrane hyperpolarization (GO:0060081)3.03601767
106nucleobase catabolic process (GO:0046113)3.03032915
107positive regulation of synapse assembly (GO:0051965)3.02697669
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02661595
109positive regulation of dendritic spine development (GO:0060999)3.02193422
110positive regulation of neurotransmitter secretion (GO:0001956)3.01469195
111dendritic spine organization (GO:0097061)3.00054519
112regulation of voltage-gated calcium channel activity (GO:1901385)2.99275615
113regulation of dendritic spine development (GO:0060998)2.98332765
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97728218
115membrane depolarization during action potential (GO:0086010)2.97451106
116positive regulation of potassium ion transmembrane transport (GO:1901381)2.96855327
117synapse organization (GO:0050808)2.96155668
118regulation of synaptic transmission (GO:0050804)2.95820472
119positive regulation of neurotransmitter transport (GO:0051590)2.94396601
120positive regulation of synaptic transmission (GO:0050806)2.93584311
121startle response (GO:0001964)2.92718411
122synaptic transmission (GO:0007268)2.92593806
123neuromuscular synaptic transmission (GO:0007274)2.91320978
124vesicle docking involved in exocytosis (GO:0006904)2.90850641
125neurotransmitter uptake (GO:0001504)2.88045112
126regulation of respiratory system process (GO:0044065)2.84279134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.19688256
2GBX2_23144817_ChIP-Seq_PC3_Human3.64933231
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18898930
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16586549
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08607269
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76560233
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76560233
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.71212751
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69563164
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.69410961
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67362378
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65484827
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53616922
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47474718
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46018420
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.45187095
17DROSHA_22980978_ChIP-Seq_HELA_Human2.41303085
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.34302821
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33759360
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30163735
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.27712516
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.26701129
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19574581
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17898866
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.17802573
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16432172
27AR_21572438_ChIP-Seq_LNCaP_Human2.01259625
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93520277
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92463267
30TAF15_26573619_Chip-Seq_HEK293_Human1.81031668
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79264605
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75184470
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74643373
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63947686
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.62718875
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.61030458
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54772875
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54568537
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53496278
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.52366135
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47340609
42ZNF274_21170338_ChIP-Seq_K562_Hela1.44636401
43P300_19829295_ChIP-Seq_ESCs_Human1.43740529
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.41370178
45IGF1R_20145208_ChIP-Seq_DFB_Human1.34021883
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.33097254
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32833065
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.32699886
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29376327
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26154271
51AR_25329375_ChIP-Seq_VCAP_Human1.25530612
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21964755
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21603703
54AR_19668381_ChIP-Seq_PC3_Human1.21064563
55RNF2_27304074_Chip-Seq_NSC_Mouse1.20765397
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20732239
57STAT3_23295773_ChIP-Seq_U87_Human1.19552086
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.17987877
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17695106
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17422798
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.15299532
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.14730117
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.13876110
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12227816
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11692086
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10609863
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10364848
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.09534506
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08770841
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06988002
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06838542
72TCF4_23295773_ChIP-Seq_U87_Human1.05903593
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02671635
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02582098
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01966500
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01392714
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01075435
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01029595
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.00673741
80* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00648546
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00584906
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00342664
83AHR_22903824_ChIP-Seq_MCF-7_Human0.99981674
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99803357
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98820210
86FUS_26573619_Chip-Seq_HEK293_Human0.98540505
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97764250
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97192539
89SOX9_26525672_Chip-Seq_HEART_Mouse0.96774093
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96740417
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96740417
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.95302513
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95084387
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93991186
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.92861510
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.91751536
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91732445
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91406235
99KDM2B_26808549_Chip-Seq_K562_Human0.90898711
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90232490
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90140203
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89665136
103JUN_21703547_ChIP-Seq_K562_Human0.89564957
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88941334
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88876210
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.87336632
107TAL1_26923725_Chip-Seq_HPCs_Mouse0.86991052
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86902643
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86881796
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86019063
111* NANOG_18555785_Chip-Seq_ESCs_Mouse0.85807545
112CTCF_27219007_Chip-Seq_Bcells_Human0.85665004
113TP53_18474530_ChIP-ChIP_U2OS_Human0.85432589
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85088035
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84842812
116TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83248618
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81615665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.21074914
2MP0003880_abnormal_central_pattern4.86071932
3MP0003635_abnormal_synaptic_transmissio4.10439290
4MP0004270_analgesia3.55394841
5MP0002063_abnormal_learning/memory/cond3.36685694
6MP0009745_abnormal_behavioral_response3.35473052
7MP0005423_abnormal_somatic_nervous3.31417410
8MP0002064_seizures3.09325180
9MP0001968_abnormal_touch/_nociception2.97228927
10MP0009046_muscle_twitch2.95345199
11MP0002572_abnormal_emotion/affect_behav2.83767691
12MP0002734_abnormal_mechanical_nocicepti2.58387328
13MP0001486_abnormal_startle_reflex2.57535541
14MP0002272_abnormal_nervous_system2.44661970
15MP0000778_abnormal_nervous_system2.32672293
16MP0002822_catalepsy2.30697686
17MP0002736_abnormal_nociception_after2.28853582
18MP0001501_abnormal_sleep_pattern2.19864931
19MP0001440_abnormal_grooming_behavior2.17099992
20MP0002735_abnormal_chemical_nociception2.14286694
21MP0002733_abnormal_thermal_nociception2.10546122
22MP0006276_abnormal_autonomic_nervous2.00286635
23MP0002184_abnormal_innervation1.96513194
24MP0002067_abnormal_sensory_capabilities1.95407778
25MP0001970_abnormal_pain_threshold1.94856288
26MP0005646_abnormal_pituitary_gland1.92018318
27MP0004858_abnormal_nervous_system1.91117981
28MP0002557_abnormal_social/conspecific_i1.87704505
29MP0005645_abnormal_hypothalamus_physiol1.84805519
30MP0001984_abnormal_olfaction1.79475504
31* MP0004811_abnormal_neuron_physiology1.74541328
32MP0004924_abnormal_behavior1.73267608
33MP0005386_behavior/neurological_phenoty1.73267608
34MP0003329_amyloid_beta_deposits1.71979483
35MP0009780_abnormal_chondrocyte_physiolo1.71896148
36MP0008569_lethality_at_weaning1.71745819
37MP0001529_abnormal_vocalization1.66763029
38MP0000955_abnormal_spinal_cord1.65297146
39MP0003122_maternal_imprinting1.63295615
40MP0002909_abnormal_adrenal_gland1.60476480
41MP0003787_abnormal_imprinting1.56686541
42MP0004885_abnormal_endolymph1.52028582
43MP0002882_abnormal_neuron_morphology1.48926907
44* MP0002066_abnormal_motor_capabilities/c1.40990961
45MP0001502_abnormal_circadian_rhythm1.36379654
46MP0001905_abnormal_dopamine_level1.35408342
47MP0006292_abnormal_olfactory_placode1.34212181
48MP0000569_abnormal_digit_pigmentation1.33269411
49MP0003879_abnormal_hair_cell1.31528429
50MP0004142_abnormal_muscle_tone1.28471481
51* MP0002152_abnormal_brain_morphology1.22469949
52MP0003633_abnormal_nervous_system1.22383345
53MP0001986_abnormal_taste_sensitivity1.06016708
54MP0003631_nervous_system_phenotype1.05635073
55MP0000631_abnormal_neuroendocrine_gland1.05527183
56MP0001188_hyperpigmentation1.04878429
57MP0004742_abnormal_vestibular_system1.02825057
58MP0008877_abnormal_DNA_methylation0.96495846
59MP0002069_abnormal_eating/drinking_beha0.96136239
60MP0010386_abnormal_urinary_bladder0.95755285
61MP0003634_abnormal_glial_cell0.95595669
62MP0005551_abnormal_eye_electrophysiolog0.94438720
63MP0005394_taste/olfaction_phenotype0.93166674
64MP0005499_abnormal_olfactory_system0.93166674
65MP0000751_myopathy0.91220933
66MP0003890_abnormal_embryonic-extraembry0.90371236
67MP0001177_atelectasis0.90308513
68MP0008872_abnormal_physiological_respon0.87555159
69MP0002638_abnormal_pupillary_reflex0.86282487
70MP0002234_abnormal_pharynx_morphology0.86097467
71MP0003123_paternal_imprinting0.86043667
72MP0002229_neurodegeneration0.85873508
73MP0002653_abnormal_ependyma_morphology0.84681406
74MP0005253_abnormal_eye_physiology0.83795872
75MP0004133_heterotaxia0.83787097
76MP0002752_abnormal_somatic_nervous0.83415201
77MP0001963_abnormal_hearing_physiology0.82459249
78MP0008961_abnormal_basal_metabolism0.81599145
79MP0000049_abnormal_middle_ear0.79741397
80MP0004085_abnormal_heartbeat0.79508399
81MP0000566_synostosis0.79230061
82MP0003136_yellow_coat_color0.78817519
83MP0003690_abnormal_glial_cell0.78813076
84MP0003632_abnormal_nervous_system0.78043808
85MP0005187_abnormal_penis_morphology0.77094467
86MP0004145_abnormal_muscle_electrophysio0.77041903
87MP0003938_abnormal_ear_development0.75678234
88MP0008874_decreased_physiological_sensi0.74523915
89MP0003137_abnormal_impulse_conducting0.74328708
90* MP0003861_abnormal_nervous_system0.73490772
91MP0003283_abnormal_digestive_organ0.73389093
92MP0005535_abnormal_body_temperature0.72869111
93MP0004215_abnormal_myocardial_fiber0.69931147
94MP0003172_abnormal_lysosome_physiology0.69035668
95MP0002837_dystrophic_cardiac_calcinosis0.68379441
96MP0000604_amyloidosis0.68346518
97MP0000920_abnormal_myelination0.66904937
98MP0002090_abnormal_vision0.66749990
99MP0001299_abnormal_eye_distance/0.63584481
100MP0000579_abnormal_nail_morphology0.63185022
101MP0001943_abnormal_respiration0.63165391
102MP0003121_genomic_imprinting0.62911351
103MP0005195_abnormal_posterior_eye0.62456936
104MP0000013_abnormal_adipose_tissue0.61972775
105MP0001485_abnormal_pinna_reflex0.61872887
106MP0003075_altered_response_to0.61561019
107MP0008789_abnormal_olfactory_epithelium0.60161479
108MP0002081_perinatal_lethality0.59766817
109MP0001664_abnormal_digestion0.59660659
110MP0000026_abnormal_inner_ear0.59304396
111MP0005167_abnormal_blood-brain_barrier0.59301500
112MP0004233_abnormal_muscle_weight0.58819800
113MP0010769_abnormal_survival0.57769230
114MP0010770_preweaning_lethality0.57278817
115MP0002082_postnatal_lethality0.57278817
116MP0005623_abnormal_meninges_morphology0.56180767
117MP0005409_darkened_coat_color0.55490271
118MP0006072_abnormal_retinal_apoptosis0.55347054

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.31604756
2Myokymia (HP:0002411)6.27662531
3Focal seizures (HP:0007359)5.60153103
4Visual hallucinations (HP:0002367)4.84498627
5Epileptic encephalopathy (HP:0200134)4.80797446
6Progressive cerebellar ataxia (HP:0002073)4.33010811
7Febrile seizures (HP:0002373)4.14725429
8Atonic seizures (HP:0010819)4.11897850
9Absence seizures (HP:0002121)3.98956130
10Generalized tonic-clonic seizures (HP:0002069)3.71481523
11Dialeptic seizures (HP:0011146)3.62874781
12Broad-based gait (HP:0002136)3.59948978
13Cerebral hypomyelination (HP:0006808)3.56528094
14Action tremor (HP:0002345)3.51258724
15Supranuclear gaze palsy (HP:0000605)3.49062459
16Abnormal eating behavior (HP:0100738)3.39493684
17Hyperventilation (HP:0002883)3.32834702
18Ankle clonus (HP:0011448)3.32722711
19Poor eye contact (HP:0000817)3.31791524
20Mutism (HP:0002300)3.21845161
21Impaired vibration sensation in the lower limbs (HP:0002166)3.21276167
22Truncal ataxia (HP:0002078)3.06261001
23Depression (HP:0000716)3.05287922
24Impaired social interactions (HP:0000735)3.02100075
25Abnormal social behavior (HP:0012433)3.02100075
26Drooling (HP:0002307)2.97480113
27Excessive salivation (HP:0003781)2.97480113
28Amblyopia (HP:0000646)2.97127979
29Dysdiadochokinesis (HP:0002075)2.97102341
30Urinary bladder sphincter dysfunction (HP:0002839)2.96534278
31Papilledema (HP:0001085)2.93228451
32Gaze-evoked nystagmus (HP:0000640)2.89069637
33Polyphagia (HP:0002591)2.87992571
34Nephrogenic diabetes insipidus (HP:0009806)2.87073962
35Anxiety (HP:0000739)2.84835959
36Limb dystonia (HP:0002451)2.83355183
37Metabolic alkalosis (HP:0200114)2.83326604
38Postural instability (HP:0002172)2.79019799
39Morphological abnormality of the inner ear (HP:0011390)2.78227218
40Oligodactyly (hands) (HP:0001180)2.76711952
41Conjugated hyperbilirubinemia (HP:0002908)2.75823434
42Genetic anticipation (HP:0003743)2.74021759
43Hemiparesis (HP:0001269)2.73808012
44Delusions (HP:0000746)2.73296256
45Dysmetria (HP:0001310)2.73122854
46Vitreoretinal degeneration (HP:0000655)2.71825642
47Progressive inability to walk (HP:0002505)2.69209994
48Hip dysplasia (HP:0001385)2.68000904
49Urinary urgency (HP:0000012)2.62610027
50Hypokalemic alkalosis (HP:0001949)2.61478400
51Neurofibrillary tangles (HP:0002185)2.60157825
52Megalencephaly (HP:0001355)2.59249256
53Cerebral inclusion bodies (HP:0100314)2.56435300
54Abnormality of binocular vision (HP:0011514)2.55624661
55Diplopia (HP:0000651)2.55624661
56Epileptiform EEG discharges (HP:0011182)2.53070875
57Fetal akinesia sequence (HP:0001989)2.50067021
58Torticollis (HP:0000473)2.46333818
59Abnormality of the lower motor neuron (HP:0002366)2.45479473
60Spastic gait (HP:0002064)2.44712544
61Abnormality of the corticospinal tract (HP:0002492)2.43674284
62EEG with generalized epileptiform discharges (HP:0011198)2.42292670
63Stereotypic behavior (HP:0000733)2.39307086
64Insidious onset (HP:0003587)2.38285067
65Termporal pattern (HP:0011008)2.38285067
66Bradykinesia (HP:0002067)2.35148143
67Agitation (HP:0000713)2.34901377
68Hyperaldosteronism (HP:0000859)2.33020895
69Impaired smooth pursuit (HP:0007772)2.32274276
70Focal dystonia (HP:0004373)2.30151503
71Hypsarrhythmia (HP:0002521)2.30059495
72Pheochromocytoma (HP:0002666)2.27276762
73Absent speech (HP:0001344)2.22673294
74Lower limb muscle weakness (HP:0007340)2.22072126
75Hemiplegia (HP:0002301)2.21439166
76Scanning speech (HP:0002168)2.20652110
77Inability to walk (HP:0002540)2.19698906
78Abnormality of ocular smooth pursuit (HP:0000617)2.17171125
79Amyotrophic lateral sclerosis (HP:0007354)2.16771406
80Intention tremor (HP:0002080)2.16284060
81CNS hypomyelination (HP:0003429)2.13104866
82Failure to thrive in infancy (HP:0001531)2.10780613
83Oligodactyly (HP:0012165)2.09453160
84Abnormal EKG (HP:0003115)2.08641218
85Abnormality of the right ventricle (HP:0001707)2.08502463
86Abnormality of the 4th metacarpal (HP:0010012)2.07745187
87Status epilepticus (HP:0002133)2.06289762
88Impaired vibratory sensation (HP:0002495)2.04198346
89Abnormality of the aortic arch (HP:0012303)2.02228472
90Fibular hypoplasia (HP:0003038)2.02175441
91Split foot (HP:0001839)2.01393796
92Craniofacial dystonia (HP:0012179)2.00347814
93Blue irides (HP:0000635)2.00156356
94Renal salt wasting (HP:0000127)2.00135751
95Generalized myoclonic seizures (HP:0002123)1.98883939
96Abnormality of salivation (HP:0100755)1.98153542
97Protruding tongue (HP:0010808)1.97062919
98Hypoplasia of the corpus callosum (HP:0002079)1.95395724
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92173539
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.92173539
101Akinesia (HP:0002304)1.91961766
102Neuroendocrine neoplasm (HP:0100634)1.91881411
103Aplasia involving bones of the upper limbs (HP:0009823)1.91132386
104Aplasia of the phalanges of the hand (HP:0009802)1.91132386
105Aplasia involving bones of the extremities (HP:0009825)1.91132386
106Incomplete penetrance (HP:0003829)1.90800998
107Specific learning disability (HP:0001328)1.90284660
108Peripheral hypomyelination (HP:0007182)1.90043687
109Insomnia (HP:0100785)1.89012992
110Rectal prolapse (HP:0002035)1.88512899
111Pointed chin (HP:0000307)1.87953155
112Sleep apnea (HP:0010535)1.87659315
113Obstructive sleep apnea (HP:0002870)1.87067298
114Hypoventilation (HP:0002791)1.85099075
115Morphological abnormality of the middle ear (HP:0008609)1.84808401
116Short 4th metacarpal (HP:0010044)1.83341051
117Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83341051
118Ventricular fibrillation (HP:0001663)1.82283178
119Gait ataxia (HP:0002066)1.80593750
120Hypoplasia of the brainstem (HP:0002365)1.80338111
121Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80338111
122Cutaneous finger syndactyly (HP:0010554)1.80094724
123Inappropriate behavior (HP:0000719)1.79377629
124Psychosis (HP:0000709)1.79323936
125Tubulointerstitial fibrosis (HP:0005576)1.78720832
126Aqueductal stenosis (HP:0002410)1.76488850
127Neuronal loss in central nervous system (HP:0002529)1.75669458
128Autism (HP:0000717)1.75561796
129Gait imbalance (HP:0002141)1.74787906
130Esotropia (HP:0000565)1.74072510
131Cutaneous syndactyly (HP:0012725)1.73804101
132Lissencephaly (HP:0001339)1.72178219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.41449217
2MARK14.18638586
3EPHA43.94520220
4MAP3K93.80490080
5MAP3K43.10323562
6NTRK22.86622607
7MINK12.73294022
8MAP2K72.61636447
9PAK62.26478695
10CASK2.25843510
11LATS12.22675038
12DAPK22.14648755
13MAP3K122.12784372
14KSR12.01295438
15TNIK1.91296117
16MAP2K41.90144440
17NTRK11.89731571
18KSR21.81534158
19MAPK131.67231856
20CAMKK11.58395580
21PRKD31.54217691
22CDK51.53897267
23MAPK121.53648256
24NUAK11.49393579
25RIPK41.46042005
26PLK21.43012950
27SIK21.41889303
28PNCK1.41811137
29PRPF4B1.38093464
30DAPK11.36490345
31CSNK1G11.35576228
32TYRO31.34673401
33CDK31.31422866
34PHKG21.23693936
35PHKG11.23693936
36PRKCG1.21390210
37UHMK11.20247621
38CDK191.19716926
39GRK51.19543936
40FES1.14098394
41LATS21.03213258
42STK381.01801788
43CAMK2A0.99376998
44EPHB20.95684655
45CDK180.93783538
46SGK2230.93054862
47SGK4940.93054862
48CSNK1G30.90857289
49PAK30.90389394
50MAP3K20.90331617
51CDK150.88621142
52SIK30.87690201
53CSNK1A1L0.87240414
54CDK140.85977070
55SGK20.83419944
56ARAF0.83087689
57RET0.82689850
58ADRBK20.81596802
59CSNK1G20.81467613
60EPHA30.80068307
61FGFR30.78974286
62CAMK10.76965028
63CDK11A0.76636512
64MAP3K130.75810514
65STK110.75732913
66DYRK1A0.74527239
67CAMKK20.74525451
68CAMK2B0.74506445
69PRKCH0.73290524
70LMTK20.72539483
71ERBB20.72082550
72SGK10.67127051
73FGFR20.65541813
74SGK30.63379374
75WNK10.61215414
76MARK20.60741343
77BCR0.60102473
78OXSR10.59297342
79ALK0.58983921
80MAP2K60.58716159
81RAF10.58301390
82AKT30.56044420
83PRKCZ0.55669986
84TAOK10.53497860
85LIMK10.53132611
86WNK30.53024190
87CAMK1G0.52872978
88PRKCE0.52481262
89BMPR20.51349675
90DMPK0.50302531
91PTK2B0.48645897
92RPS6KA30.47640568
93PINK10.46991920
94TNK20.46120420
95CSNK1E0.44693297
96ERBB30.44225614
97FYN0.44072260
98ROCK10.43442990
99MAP3K60.43415833
100FGR0.42837048
101MAPK100.42714930
102CSNK1A10.42280226
103RPS6KA20.40335673
104NME10.39880050
105CCNB10.39695530
106NEK60.39188494
107PDK10.38748700
108PRKG10.38667510
109DYRK1B0.38654059
110CDC42BPA0.38117444
111FER0.36625284
112CAMK2G0.36537472
113DYRK20.36410995
114CAMK2D0.35946212
115CAMK40.35521666
116PDPK10.35020416
117MAP3K10.34999315
118TRIM280.34377076
119CSNK1D0.33784404
120NEK10.33082613
121FGFR10.33018189
122ROCK20.32909881
123RPS6KB10.32746343
124PKN10.32633788
125MAP2K10.32628685
126PRKCB0.32323852
127PRKACA0.32267664
128RIPK10.32075362
129MAP4K20.31398044
130GSK3B0.31373532

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99011564
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20973262
3GABAergic synapse_Homo sapiens_hsa047272.81932133
4Circadian entrainment_Homo sapiens_hsa047132.69606865
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68466656
6Olfactory transduction_Homo sapiens_hsa047402.65318376
7Glutamatergic synapse_Homo sapiens_hsa047242.60939566
8Morphine addiction_Homo sapiens_hsa050322.53225113
9Long-term potentiation_Homo sapiens_hsa047202.52632586
10Amphetamine addiction_Homo sapiens_hsa050312.39616995
11Dopaminergic synapse_Homo sapiens_hsa047282.18455311
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14371353
13Salivary secretion_Homo sapiens_hsa049702.13614073
14Insulin secretion_Homo sapiens_hsa049111.95698210
15Cholinergic synapse_Homo sapiens_hsa047251.91382259
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88633164
17Gastric acid secretion_Homo sapiens_hsa049711.84633920
18Taste transduction_Homo sapiens_hsa047421.82875262
19Cocaine addiction_Homo sapiens_hsa050301.74837085
20Serotonergic synapse_Homo sapiens_hsa047261.73617325
21Long-term depression_Homo sapiens_hsa047301.70390900
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70158763
23Renin secretion_Homo sapiens_hsa049241.70053946
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62876721
25Oxytocin signaling pathway_Homo sapiens_hsa049211.58454163
26Calcium signaling pathway_Homo sapiens_hsa040201.55676484
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53011858
28Axon guidance_Homo sapiens_hsa043601.43394671
29Gap junction_Homo sapiens_hsa045401.41861298
30GnRH signaling pathway_Homo sapiens_hsa049121.40972042
31Collecting duct acid secretion_Homo sapiens_hsa049661.40050992
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29716542
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27508729
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24561805
35cAMP signaling pathway_Homo sapiens_hsa040241.23823442
36Glioma_Homo sapiens_hsa052141.17347791
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15671986
38Estrogen signaling pathway_Homo sapiens_hsa049151.15569786
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13458447
40ErbB signaling pathway_Homo sapiens_hsa040121.12886680
41Type II diabetes mellitus_Homo sapiens_hsa049301.12482291
42Vitamin B6 metabolism_Homo sapiens_hsa007501.10173647
43Melanogenesis_Homo sapiens_hsa049161.09983475
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04582295
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00508770
46Cardiac muscle contraction_Homo sapiens_hsa042600.95421412
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93707553
48Nitrogen metabolism_Homo sapiens_hsa009100.93548483
49Vibrio cholerae infection_Homo sapiens_hsa051100.91248924
50Dorso-ventral axis formation_Homo sapiens_hsa043200.88684307
51Oocyte meiosis_Homo sapiens_hsa041140.84778773
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.84021638
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.80783277
54Phototransduction_Homo sapiens_hsa047440.79702641
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79315884
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.78159805
57Pancreatic secretion_Homo sapiens_hsa049720.75288139
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73551459
59Choline metabolism in cancer_Homo sapiens_hsa052310.73371432
60Dilated cardiomyopathy_Homo sapiens_hsa054140.72134965
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72123351
62Butanoate metabolism_Homo sapiens_hsa006500.70558188
63MAPK signaling pathway_Homo sapiens_hsa040100.70461531
64Thyroid hormone synthesis_Homo sapiens_hsa049180.69740460
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68896973
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68467783
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.67823890
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66961901
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66684760
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65693148
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62723760
72Hippo signaling pathway_Homo sapiens_hsa043900.62716562
73Ras signaling pathway_Homo sapiens_hsa040140.59783979
74Alcoholism_Homo sapiens_hsa050340.58131202
75Endometrial cancer_Homo sapiens_hsa052130.58065959
76VEGF signaling pathway_Homo sapiens_hsa043700.57211010
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56408759
78Rap1 signaling pathway_Homo sapiens_hsa040150.55030740
79Type I diabetes mellitus_Homo sapiens_hsa049400.54902931
80Ether lipid metabolism_Homo sapiens_hsa005650.54565628
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54083920
82Wnt signaling pathway_Homo sapiens_hsa043100.52930578
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.52410425
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51758933
85Prion diseases_Homo sapiens_hsa050200.49925676
86Glucagon signaling pathway_Homo sapiens_hsa049220.48864304
87Bile secretion_Homo sapiens_hsa049760.47010767
88Renal cell carcinoma_Homo sapiens_hsa052110.46732476
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45366291
90Non-small cell lung cancer_Homo sapiens_hsa052230.44881063
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44066549
92mTOR signaling pathway_Homo sapiens_hsa041500.43663958
93Arginine and proline metabolism_Homo sapiens_hsa003300.41830169
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41457448
95Colorectal cancer_Homo sapiens_hsa052100.41213390
96Inositol phosphate metabolism_Homo sapiens_hsa005620.40230326
97Endocytosis_Homo sapiens_hsa041440.40203923
98Insulin signaling pathway_Homo sapiens_hsa049100.40122309
99Circadian rhythm_Homo sapiens_hsa047100.39170770
100Basal cell carcinoma_Homo sapiens_hsa052170.36765633
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36523566
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35579054
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35571121
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35402609
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34062811
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34049831
107Ovarian steroidogenesis_Homo sapiens_hsa049130.33249969
108Alzheimers disease_Homo sapiens_hsa050100.32759079
109African trypanosomiasis_Homo sapiens_hsa051430.32546639
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30056882
111Linoleic acid metabolism_Homo sapiens_hsa005910.29277768
112Hedgehog signaling pathway_Homo sapiens_hsa043400.28333681
113Chemokine signaling pathway_Homo sapiens_hsa040620.27600616
114Steroid biosynthesis_Homo sapiens_hsa001000.27063041
115Fatty acid biosynthesis_Homo sapiens_hsa000610.26548625
116beta-Alanine metabolism_Homo sapiens_hsa004100.25908660
117AMPK signaling pathway_Homo sapiens_hsa041520.25751071

Most similar genes based on co-expression Upload to Enrichr

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