ASXL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)5.75011271
2nuclear pore complex assembly (GO:0051292)5.71810978
3presynaptic membrane assembly (GO:0097105)4.70017150
4nuclear pore organization (GO:0006999)4.57966969
5mature B cell differentiation (GO:0002335)4.26767695
6Golgi to endosome transport (GO:0006895)4.14415039
7regulation of RNA export from nucleus (GO:0046831)4.04288963
8pore complex assembly (GO:0046931)4.02753809
9protein heterotetramerization (GO:0051290)3.80370659
10histone H3-K4 trimethylation (GO:0080182)3.80292030
11positive regulation of gamma-delta T cell activation (GO:0046645)3.79682033
12presynaptic membrane organization (GO:0097090)3.65279915
13regulation of nucleobase-containing compound transport (GO:0032239)3.58752767
14hepatocyte apoptotic process (GO:0097284)3.51567026
15hypotonic response (GO:0006971)3.49896700
16negative regulation of translation, ncRNA-mediated (GO:0040033)3.40665826
17regulation of translation, ncRNA-mediated (GO:0045974)3.40665826
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.40665826
19embryonic process involved in female pregnancy (GO:0060136)3.37149855
20positive regulation of defense response to virus by host (GO:0002230)3.32202571
21negative regulation of DNA repair (GO:0045738)3.30173796
22histone H3-K4 methylation (GO:0051568)3.25717589
23negative T cell selection (GO:0043383)3.22339821
24regulation of stem cell maintenance (GO:2000036)3.21485413
25pre-miRNA processing (GO:0031054)3.18162056
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14109788
27cytoplasmic mRNA processing body assembly (GO:0033962)3.10456462
28positive T cell selection (GO:0043368)3.06742574
29negative regulation of cell killing (GO:0031342)3.04974643
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04974643
31generation of neurons (GO:0048699)3.04495135
32alpha-beta T cell differentiation involved in immune response (GO:0002293)3.04407135
33alpha-beta T cell activation involved in immune response (GO:0002287)3.04407135
34T cell differentiation involved in immune response (GO:0002292)3.04407135
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.03081297
36centriole replication (GO:0007099)3.01499826
37activated T cell proliferation (GO:0050798)3.01176577
38regulation of metalloenzyme activity (GO:0048552)3.00697602
39positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.00156502
40regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.00156502
41response to folic acid (GO:0051593)2.97441502
42positive regulation of natural killer cell mediated immunity (GO:0002717)2.96377727
43positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.96377727
44iron ion import (GO:0097286)2.94280744
45regulation of interleukin-6 biosynthetic process (GO:0045408)2.91626994
46ribosomal small subunit biogenesis (GO:0042274)2.91516535
47alpha-beta T cell differentiation (GO:0046632)2.91005422
48radial glial cell differentiation (GO:0060019)2.90454101
49regulation of natural killer cell mediated immunity (GO:0002715)2.89604134
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89604134
51negative thymic T cell selection (GO:0045060)2.88795443
52phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88596941
53interkinetic nuclear migration (GO:0022027)2.87917212
54postsynaptic membrane organization (GO:0001941)2.84940663
55positive thymic T cell selection (GO:0045059)2.84694591
56CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.84645626
57T-helper cell differentiation (GO:0042093)2.84645626
58DNA ligation (GO:0006266)2.83989145
59protein K63-linked deubiquitination (GO:0070536)2.83612891
60definitive hemopoiesis (GO:0060216)2.83385664
61alpha-beta T cell activation (GO:0046631)2.82198795
62* regulation of histone H3-K27 methylation (GO:0061085)2.80500883
63positive regulation of granulocyte differentiation (GO:0030854)2.79652512
64regulation of B cell receptor signaling pathway (GO:0050855)2.79446780
65histone lysine demethylation (GO:0070076)2.79433633
66glucocorticoid receptor signaling pathway (GO:0042921)2.76927543
67corticosteroid receptor signaling pathway (GO:0031958)2.74707536
68centriole assembly (GO:0098534)2.73286848
69positive regulation of protein import into nucleus, translocation (GO:0033160)2.73208393
70detection of molecule of bacterial origin (GO:0032490)2.72692415
71histone H3-K36 demethylation (GO:0070544)2.72622595
72cellular response to interleukin-15 (GO:0071350)2.72247992
73monoubiquitinated protein deubiquitination (GO:0035520)2.71317501
74regulation of DNA endoreduplication (GO:0032875)2.69799461
75histone demethylation (GO:0016577)2.69058621
76regulation of necroptotic process (GO:0060544)2.68413999
77peptidyl-lysine trimethylation (GO:0018023)2.67622759
78CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.66531485
79leukocyte aggregation (GO:0070486)2.66188675
80positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.65713737
81regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.65713737
82positive regulation of keratinocyte differentiation (GO:0045618)2.64497365
83positive regulation of mRNA catabolic process (GO:0061014)2.63996969
84positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63946453
85negative regulation of inclusion body assembly (GO:0090084)2.61613127
86cellular response to ethanol (GO:0071361)2.58927314
87T cell selection (GO:0045058)2.58063945
88mitotic sister chromatid cohesion (GO:0007064)2.58021537
89positive regulation of cell killing (GO:0031343)2.57877101
90T cell differentiation (GO:0030217)2.57468559
91histone H3-K9 demethylation (GO:0033169)2.56105901
92regulation of isotype switching to IgG isotypes (GO:0048302)2.55940780
93peptidyl-threonine phosphorylation (GO:0018107)2.55411996
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55124385
95negative regulation of T-helper cell differentiation (GO:0045623)2.55124385
96cell-substrate junction assembly (GO:0007044)2.54842826
97regulation of T cell tolerance induction (GO:0002664)2.52542888
98peptidyl-threonine modification (GO:0018210)2.52452068
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.51725465
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51283911
101regulation of histone H3-K4 methylation (GO:0051569)2.51264816
102embryonic camera-type eye morphogenesis (GO:0048596)2.49600028
103thymic T cell selection (GO:0045061)2.48508967
104mitotic chromosome condensation (GO:0007076)2.46819852
105T cell receptor signaling pathway (GO:0050852)2.45585704
106mast cell activation (GO:0045576)2.44924270
107antigen receptor-mediated signaling pathway (GO:0050851)2.44796954
108tolerance induction (GO:0002507)2.43172375
109hemidesmosome assembly (GO:0031581)2.42742600
110NLS-bearing protein import into nucleus (GO:0006607)2.42673351
111viral transcription (GO:0019083)2.41791799
112developmental pigmentation (GO:0048066)2.41592799
113negative regulation of erythrocyte differentiation (GO:0045647)2.41307981
114phosphatidylinositol phosphorylation (GO:0046854)2.40570101
115regulation of gamma-delta T cell differentiation (GO:0045586)2.40502615
116germinal center formation (GO:0002467)2.39407742
117response to epidermal growth factor (GO:0070849)2.39353839
118lymphoid progenitor cell differentiation (GO:0002320)2.38618075
119regulation of interleukin-2 biosynthetic process (GO:0045076)2.38600691
120regulation of mRNA catabolic process (GO:0061013)2.38503008
121cellular extravasation (GO:0045123)2.38163822
122T cell homeostasis (GO:0043029)2.37852007
123erythrocyte maturation (GO:0043249)2.37581673
124protein K48-linked deubiquitination (GO:0071108)2.36894297
125regulation of gamma-delta T cell activation (GO:0046643)2.36811261
126regulation of cell killing (GO:0031341)2.36512543
127positive regulation by host of viral transcription (GO:0043923)2.35458667
128trophectodermal cell differentiation (GO:0001829)2.35019844
129negative regulation of execution phase of apoptosis (GO:1900118)2.34918940
130positive regulation of interleukin-1 beta secretion (GO:0050718)2.34235558
131preassembly of GPI anchor in ER membrane (GO:0016254)2.34033262
132response to interleukin-15 (GO:0070672)2.33800971
133pinocytosis (GO:0006907)2.33742306
134tRNA modification (GO:0006400)2.33378042
135DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.32626587
136neutrophil activation (GO:0042119)2.32156002
137histone H3 acetylation (GO:0043966)2.31841811
138negative regulation of alpha-beta T cell activation (GO:0046636)2.31816335
139B cell homeostasis (GO:0001782)2.31142716
140regulation of establishment of cell polarity (GO:2000114)2.31136908
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30886552
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.30886552
143modulation by symbiont of host immune response (GO:0052553)2.30886552
144positive regulation by symbiont of host defense response (GO:0052509)2.30886552
145modulation by symbiont of host defense response (GO:0052031)2.30886552
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30886552
147ribosomal large subunit biogenesis (GO:0042273)2.30627838
148response to laminar fluid shear stress (GO:0034616)2.30323822
149skin morphogenesis (GO:0043589)2.30038421
150mammary gland epithelial cell proliferation (GO:0033598)2.29767539
151protein demethylation (GO:0006482)2.29418359
152protein dealkylation (GO:0008214)2.29418359
153focal adhesion assembly (GO:0048041)2.25961743
154cell-substrate adherens junction assembly (GO:0007045)2.25961743
155B cell receptor signaling pathway (GO:0050853)2.25880149
156membrane raft organization (GO:0031579)2.24453051
157megakaryocyte development (GO:0035855)2.23887564
158macrophage activation involved in immune response (GO:0002281)2.22919858
159protein export from nucleus (GO:0006611)2.22881752
160protein localization to endosome (GO:0036010)2.22030442
161antigen processing and presentation via MHC class Ib (GO:0002475)2.20661771
162cellular response to epidermal growth factor stimulus (GO:0071364)2.20536669
163positive regulation of cellular response to insulin stimulus (GO:1900078)2.18862563
164desmosome organization (GO:0002934)2.18588073
165negative regulation of anoikis (GO:2000811)2.17296518
166negative regulation of necroptotic process (GO:0060546)2.17253180
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.16331668
168N-terminal protein amino acid acetylation (GO:0006474)2.16139119
169mRNA transcription (GO:0009299)2.14981230
170mRNA stabilization (GO:0048255)2.13621889
171RNA stabilization (GO:0043489)2.13621889
172cortical actin cytoskeleton organization (GO:0030866)2.13457014
173negative regulation of T cell mediated immunity (GO:0002710)2.13350203
174antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.13342218
175COPII vesicle coating (GO:0048208)2.10315836
176regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.10283868
177cytoskeletal anchoring at plasma membrane (GO:0007016)2.10147076
178peptidyl-serine phosphorylation (GO:0018105)2.08925604
179mesodermal cell differentiation (GO:0048333)2.08377318
180antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.08287553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.62205853
2E2F7_22180533_ChIP-Seq_HELA_Human5.34326114
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.31614444
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.16716812
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.14576910
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07870767
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.76742116
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.72096546
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.66036414
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59342803
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57550265
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53990637
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.46661184
14IRF1_19129219_ChIP-ChIP_H3396_Human2.45011702
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.36994558
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36241904
17SCL_19346495_ChIP-Seq_HPC-7_Human2.30856757
18MYC_22102868_ChIP-Seq_BL_Human2.29893288
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.13843324
20RUNX_20019798_ChIP-Seq_JUKART_Human2.12895837
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.09442993
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02520992
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99933284
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99535437
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91005335
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.84913403
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84625962
28* MYB_26560356_Chip-Seq_TH2_Human1.82720498
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81260137
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80061569
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78958358
32TCF7_22412390_ChIP-Seq_EML_Mouse1.78249921
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78203912
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76826529
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.74971708
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73024936
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.72243987
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71958778
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68119736
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67603459
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67603459
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66004811
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.65841529
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.64131086
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.62882998
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60260497
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.59826708
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58998923
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58998923
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58998923
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.56415414
52GATA1_22025678_ChIP-Seq_K562_Human1.56140656
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.53021019
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52739169
55SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52034582
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49375835
57* MYB_26560356_Chip-Seq_TH1_Human1.49139090
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.48920100
59P300_18555785_Chip-Seq_ESCs_Mouse1.48454833
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47178290
61SPI1_23127762_ChIP-Seq_K562_Human1.45758454
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44017900
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.43929642
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42203585
65P53_22387025_ChIP-Seq_ESCs_Mouse1.41458203
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40640114
67NMYC_18555785_Chip-Seq_ESCs_Mouse1.40481371
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.40149476
69* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39850234
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.39567555
71PU_27001747_Chip-Seq_BMDM_Mouse1.39291517
72* FOXA2_19822575_ChIP-Seq_HepG2_Human1.38949944
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.37913373
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37910999
75* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37528681
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36734151
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36593831
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36522943
79MAF_26560356_Chip-Seq_TH1_Human1.35286371
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35149274
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35041806
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34781228
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.34669350
84AR_21909140_ChIP-Seq_LNCAP_Human1.34539766
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34339529
86* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32900649
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.32836803
88RUNX1_27457419_Chip-Seq_LIVER_Mouse1.31552594
89SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31174470
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29447948
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28528260
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.27774550
93* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27695673
94EGR1_19374776_ChIP-ChIP_THP-1_Human1.25899165
95ZFX_18555785_Chip-Seq_ESCs_Mouse1.25397454
96ELK1_19687146_ChIP-ChIP_HELA_Human1.25174151
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.24956249
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24905583
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.24520521
100EWS_26573619_Chip-Seq_HEK293_Human1.24268535
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23964770
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23489889
103* SPI1_23547873_ChIP-Seq_NB4_Human1.22915653
104BP1_19119308_ChIP-ChIP_Hs578T_Human1.22825725
105CLOCK_20551151_ChIP-Seq_293T_Human1.22000707
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21439083
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.20847081
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19511327
109BRD4_25478319_ChIP-Seq_HGPS_Human1.18275722
110ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18140729
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.17913963
112* TFEB_21752829_ChIP-Seq_HELA_Human1.16321189
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.16151757
114FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15560809
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14852092
116CHD1_26751641_Chip-Seq_LNCaP_Human1.14681855
117PU1_27457419_Chip-Seq_LIVER_Mouse1.14498217
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13569105
119GATA2_19941826_ChIP-Seq_K562_Human1.12519311
120TAF15_26573619_Chip-Seq_HEK293_Human1.12305101
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11694546
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10679781
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09870642
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09350175
125GATA6_25053715_ChIP-Seq_YYC3_Human1.08839724
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.08828014
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08650243
128VDR_24787735_ChIP-Seq_THP-1_Human1.08418058
129GATA1_19941826_ChIP-Seq_K562_Human1.08313605
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08118189
131ER_23166858_ChIP-Seq_MCF-7_Human1.05372016
132KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04430274
133AHR_22903824_ChIP-Seq_MCF-7_Human1.03512043
134VDR_21846776_ChIP-Seq_THP-1_Human1.03251623
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03216781
136STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02789917
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02696475
138RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01314843
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00992948
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00314268
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99946425
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99543304
143UTX_26944678_Chip-Seq_JUKART_Human0.98450440
144VDR_23849224_ChIP-Seq_CD4+_Human0.98437448
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97766071
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.97494552
147TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97455467
148VDR_24763502_ChIP-Seq_THP-1_Human0.97188914
149E2F1_21310950_ChIP-Seq_MCF-7_Human0.96976263
150ZNF263_19887448_ChIP-Seq_K562_Human0.96766557
151TBX20_22080862_ChIP-Seq_HEART_Mouse0.96689403
152TBX20_22328084_ChIP-Seq_HEART_Mouse0.96689403
153FUS_26573619_Chip-Seq_HEK293_Human0.96300228
154* KDM2B_26808549_Chip-Seq_DND41_Human0.95294245
155NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94051738
156RUNX1_22412390_ChIP-Seq_EML_Mouse0.93512287
157GATA3_27048872_Chip-Seq_THYMUS_Human0.93259657
158* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90316290
159TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90172440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle3.63078275
2MP0003136_yellow_coat_color3.62071586
3MP0002009_preneoplasia3.57209846
4MP0005409_darkened_coat_color3.13322613
5MP0005671_abnormal_response_to2.80347066
6MP0005174_abnormal_tail_pigmentation2.69276609
7MP0003763_abnormal_thymus_physiology2.67550413
8MP0006292_abnormal_olfactory_placode2.63235349
9MP0008057_abnormal_DNA_replication2.60078736
10MP0005451_abnormal_body_composition2.58984378
11MP0010352_gastrointestinal_tract_polyps2.55818111
12MP0001188_hyperpigmentation2.53026446
13MP0002877_abnormal_melanocyte_morpholog2.50872401
14MP0002166_altered_tumor_susceptibility2.50159114
15MP0000566_synostosis2.43716840
16MP0005076_abnormal_cell_differentiation2.31193645
17MP0003566_abnormal_cell_adhesion2.27669573
18MP0001800_abnormal_humoral_immune2.13606697
19MP0003705_abnormal_hypodermis_morpholog2.08717831
20MP0010234_abnormal_vibrissa_follicle2.07353999
21MP0001835_abnormal_antigen_presentation2.06571976
22MP0000015_abnormal_ear_pigmentation2.05267734
23MP0004264_abnormal_extraembryonic_tissu2.03645915
24MP0005387_immune_system_phenotype1.95724054
25MP0001790_abnormal_immune_system1.95724054
26MP0005075_abnormal_melanosome_morpholog1.93309397
27MP0002006_tumorigenesis1.90170248
28MP0002277_abnormal_respiratory_mucosa1.86599186
29MP0002396_abnormal_hematopoietic_system1.85641733
30MP0003091_abnormal_cell_migration1.83626040
31MP0005000_abnormal_immune_tolerance1.81341342
32MP0002723_abnormal_immune_serum1.78431026
33MP0004185_abnormal_adipocyte_glucose1.77090904
34MP0008058_abnormal_DNA_repair1.76016821
35MP0002452_abnormal_antigen_presenting1.75249844
36MP0010094_abnormal_chromosome_stability1.74950201
37MP0002095_abnormal_skin_pigmentation1.74766931
38MP0002420_abnormal_adaptive_immunity1.73216338
39MP0001819_abnormal_immune_cell1.70302813
40MP0004233_abnormal_muscle_weight1.68069843
41MP0009379_abnormal_foot_pigmentation1.67877743
42MP0002398_abnormal_bone_marrow1.65316699
43MP0003656_abnormal_erythrocyte_physiolo1.63946012
44MP0008007_abnormal_cellular_replicative1.63294947
45MP0000569_abnormal_digit_pigmentation1.62182480
46MP0003868_abnormal_feces_composition1.61111437
47MP0000490_abnormal_crypts_of1.59113219
48MP0000703_abnormal_thymus_morphology1.59055140
49MP0003866_abnormal_defecation1.58430495
50MP0002796_impaired_skin_barrier1.54418111
51MP0000383_abnormal_hair_follicle1.53170002
52MP0000716_abnormal_immune_system1.48070203
53MP0001915_intracranial_hemorrhage1.45492110
54MP0005025_abnormal_response_to1.44119144
55MP0001873_stomach_inflammation1.43823977
56MP0009333_abnormal_splenocyte_physiolog1.41767257
57MP0003880_abnormal_central_pattern1.41191307
58MP0000465_gastrointestinal_hemorrhage1.41162781
59MP0008260_abnormal_autophagy1.40434843
60MP0003950_abnormal_plasma_membrane1.39908062
61MP0003828_pulmonary_edema1.39825002
62MP0009785_altered_susceptibility_to1.35781524
63MP0003724_increased_susceptibility_to1.33888806
64MP0002419_abnormal_innate_immunity1.33569623
65MP0002722_abnormal_immune_system1.32523250
66MP0000689_abnormal_spleen_morphology1.30048925
67MP0005023_abnormal_wound_healing1.27992655
68MP0003300_gastrointestinal_ulcer1.24922272
69MP0000372_irregular_coat_pigmentation1.24193390
70MP0002148_abnormal_hypersensitivity_rea1.23361210
71MP0002086_abnormal_extraembryonic_tissu1.21916257
72MP0003183_abnormal_peptide_metabolism1.21369073
73MP0003191_abnormal_cellular_cholesterol1.20056062
74MP0002429_abnormal_blood_cell1.19955590
75MP0003448_altered_tumor_morphology1.18213283
76MP0002060_abnormal_skin_morphology1.17953628
77MP0003172_abnormal_lysosome_physiology1.17945235
78MP0002405_respiratory_system_inflammati1.17123957
79MP0005379_endocrine/exocrine_gland_phen1.15403345
80MP0010155_abnormal_intestine_physiology1.13622373
81MP0005621_abnormal_cell_physiology1.11902419
82MP0000685_abnormal_immune_system1.11015856
83MP0001730_embryonic_growth_arrest1.06930697
84MP0003984_embryonic_growth_retardation1.06529813
85MP0003221_abnormal_cardiomyocyte_apopto1.05631028
86MP0002998_abnormal_bone_remodeling1.05334324
87MP0008438_abnormal_cutaneous_collagen1.05225008
88MP0000350_abnormal_cell_proliferation1.05196323
89MP0002938_white_spotting1.05160762
90MP0001849_ear_inflammation1.04315674
91MP0002088_abnormal_embryonic_growth/wei1.02853383
92MP0005408_hypopigmentation1.01591132
93MP0001851_eye_inflammation1.00769475
94MP0005171_absent_coat_pigmentation1.00351722
95MP0002177_abnormal_outer_ear0.99957601
96MP0003303_peritoneal_inflammation0.97865945
97MP0000613_abnormal_salivary_gland0.97407747
98MP0005275_abnormal_skin_tensile0.97270757
99MP0002132_abnormal_respiratory_system0.97049303
100MP0000858_altered_metastatic_potential0.96716895
101MP0004957_abnormal_blastocyst_morpholog0.96406826
102MP0005164_abnormal_response_to0.95975893
103MP0001216_abnormal_epidermal_layer0.95340990
104MP0001672_abnormal_embryogenesis/_devel0.94609649
105MP0005380_embryogenesis_phenotype0.94609649
106MP0004808_abnormal_hematopoietic_stem0.94147766
107MP0003787_abnormal_imprinting0.93412054
108MP0000733_abnormal_muscle_development0.91083900
109MP0003436_decreased_susceptibility_to0.89795509
110MP0001986_abnormal_taste_sensitivity0.89522662
111MP0003941_abnormal_skin_development0.89295483
112MP0001186_pigmentation_phenotype0.89131376
113MP0010630_abnormal_cardiac_muscle0.88409460
114MP0003111_abnormal_nucleus_morphology0.88208950
115MP0010307_abnormal_tumor_latency0.86068516
116MP0001661_extended_life_span0.85551551
117MP0009115_abnormal_fat_cell0.85364136
118MP0002933_joint_inflammation0.85256710
119MP0000627_abnormal_mammary_gland0.84815490
120MP0004147_increased_porphyrin_level0.84740305
121MP0003077_abnormal_cell_cycle0.84406194
122MP0002928_abnormal_bile_duct0.84191391
123MP0005501_abnormal_skin_physiology0.83627584
124MP0003045_fibrosis0.83335554
125MP0010678_abnormal_skin_adnexa0.83269065
126MP0001697_abnormal_embryo_size0.83211000
127MP0005310_abnormal_salivary_gland0.82552236
128MP0004883_abnormal_blood_vessel0.82100254
129MP0002075_abnormal_coat/hair_pigmentati0.80621390
130MP0003786_premature_aging0.79078046
131MP0004272_abnormal_basement_membrane0.78763196
132MP0003453_abnormal_keratinocyte_physiol0.77177426
133MP0002098_abnormal_vibrissa_morphology0.73988021
134MP0001845_abnormal_inflammatory_respons0.73453422
135MP0001919_abnormal_reproductive_system0.73217762
136MP0002693_abnormal_pancreas_physiology0.71964466
137MP0000371_diluted_coat_color0.71844731
138MP0003938_abnormal_ear_development0.71347370
139MP0003943_abnormal_hepatobiliary_system0.69662489
140MP0002163_abnormal_gland_morphology0.69111856
141MP0006072_abnormal_retinal_apoptosis0.69091467
142MP0005464_abnormal_platelet_physiology0.67993124
143MP0001346_abnormal_lacrimal_gland0.66651750
144MP0000920_abnormal_myelination0.65923439
145MP0004947_skin_inflammation0.65536848
146MP0002019_abnormal_tumor_incidence0.63632852
147MP0003890_abnormal_embryonic-extraembry0.62309547

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)3.61535724
2T lymphocytopenia (HP:0005403)3.49621370
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45680563
4Chromsome breakage (HP:0040012)3.44588180
5Chronic mucocutaneous candidiasis (HP:0002728)3.32634608
6Recurrent cutaneous fungal infections (HP:0011370)3.32634608
7Abnormality of T cell number (HP:0011839)3.23910682
8Subacute progressive viral hepatitis (HP:0006572)3.18608621
9Abnormality of the fingertips (HP:0001211)3.15077116
10Abnormal hemoglobin (HP:0011902)3.08212006
11Stomatitis (HP:0010280)2.97989320
12Pseudobulbar signs (HP:0002200)2.97908817
13Osteolytic defects of the hand bones (HP:0009699)2.95612554
14Osteolytic defects of the phalanges of the hand (HP:0009771)2.95612554
15Hyponatremia (HP:0002902)2.86248675
16Abnormality of renin-angiotensin system (HP:0000847)2.84865583
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.78709674
18Cone-rod dystrophy (HP:0000548)2.77190296
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72114163
20Flat acetabular roof (HP:0003180)2.66480722
21Agammaglobulinemia (HP:0004432)2.65689816
22Reticulocytopenia (HP:0001896)2.65241283
23Hyperactive renin-angiotensin system (HP:0000841)2.64385523
24IgM deficiency (HP:0002850)2.63027383
25Abnormality of chloride homeostasis (HP:0011422)2.62314674
26Recurrent fungal infections (HP:0002841)2.59908050
27Papillary thyroid carcinoma (HP:0002895)2.55734998
28Meningitis (HP:0001287)2.51626800
29Recurrent viral infections (HP:0004429)2.51468013
30Syringomyelia (HP:0003396)2.48310532
31Spinal cord lesions (HP:0100561)2.48310532
32Dysmetric saccades (HP:0000641)2.46150276
33Abnormality of chromosome stability (HP:0003220)2.45922675
34Lip pit (HP:0100267)2.41082739
35Dislocated radial head (HP:0003083)2.40051315
36Ankyloglossia (HP:0010296)2.39107149
37Asymmetry of the thorax (HP:0001555)2.37424113
38Ectopic kidney (HP:0000086)2.34732144
39Deep philtrum (HP:0002002)2.34358050
40IgG deficiency (HP:0004315)2.32917299
41Panhypogammaglobulinemia (HP:0003139)2.31940329
42Metabolic alkalosis (HP:0200114)2.31118384
43Arterial tortuosity (HP:0005116)2.30789886
44Eczematoid dermatitis (HP:0000976)2.28954744
45Thyroiditis (HP:0100646)2.28596039
46Abnormality of T cells (HP:0002843)2.27757216
47Abnormality of oral frenula (HP:0000190)2.25248142
48Abnormality of dental color (HP:0011073)2.22851654
49Chronic obstructive pulmonary disease (HP:0006510)2.22302999
50Obstructive lung disease (HP:0006536)2.22302999
51Eosinophilia (HP:0001880)2.20478181
52Prominent nose (HP:0000448)2.16695458
53Amelogenesis imperfecta (HP:0000705)2.16033182
54Abnormality of the nasal septum (HP:0000419)2.15857250
55Broad face (HP:0000283)2.13881487
56Cheilitis (HP:0100825)2.12206357
57Autoimmune hemolytic anemia (HP:0001890)2.11218005
58Abnormality of the radial head (HP:0003995)2.08990646
59Heterotopia (HP:0002282)2.08936140
60Chronic diarrhea (HP:0002028)2.07625981
61Anhidrosis (HP:0000970)2.07224332
62Volvulus (HP:0002580)2.06868709
63Inflammation of the large intestine (HP:0002037)2.06702385
64Clubbing of toes (HP:0100760)2.06583914
65Duplicated collecting system (HP:0000081)2.06427014
66Hypothermia (HP:0002045)2.05683652
67Abnormality of eosinophils (HP:0001879)2.05674578
68Prostate neoplasm (HP:0100787)2.05551738
69Lymphoma (HP:0002665)2.05384983
70Abnormality of the left ventricular outflow tract (HP:0011103)2.05333856
71Subaortic stenosis (HP:0001682)2.05333856
72Macrocytic anemia (HP:0001972)2.05214935
73Sensory axonal neuropathy (HP:0003390)2.04674510
74Triphalangeal thumb (HP:0001199)2.04528501
75Abnormality of the common coagulation pathway (HP:0010990)2.04384655
76Coarse hair (HP:0002208)2.04233445
77Pallor (HP:0000980)2.04146516
78Slow saccadic eye movements (HP:0000514)2.03641173
79Recurrent sinusitis (HP:0011108)2.02681315
80Narrow palate (HP:0000189)2.00980166
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.00957740
82Abnormality of the prostate (HP:0008775)2.00477542
83Sparse lateral eyebrow (HP:0005338)2.00352851
84Abnormality of the preputium (HP:0100587)2.00338278
85Aortic aneurysm (HP:0004942)1.99015955
86Hyperkalemia (HP:0002153)1.98829181
87Absent frontal sinuses (HP:0002688)1.98135905
88B lymphocytopenia (HP:0010976)1.98011469
89Abnormality of B cell number (HP:0010975)1.98011469
90Milia (HP:0001056)1.96859488
91Viral hepatitis (HP:0006562)1.96006905
92Recurrent skin infections (HP:0001581)1.95311048
93Spontaneous hematomas (HP:0007420)1.94713550
94Granulocytopenia (HP:0001913)1.93808652
95Delayed closure of the anterior fontanelle (HP:0001476)1.93543012
96Vascular tortuosity (HP:0004948)1.93453758
97Meckel diverticulum (HP:0002245)1.93281822
98Abnormality of the columella (HP:0009929)1.92142337
99Persistence of primary teeth (HP:0006335)1.91999480
100Severe combined immunodeficiency (HP:0004430)1.91439636
101Type I transferrin isoform profile (HP:0003642)1.89559549
102Abnormality of sodium homeostasis (HP:0010931)1.88716243
103Recurrent bacterial skin infections (HP:0005406)1.88680211
104Cerebral aneurysm (HP:0004944)1.88404069
105Macroorchidism (HP:0000053)1.87753487
106Neonatal hypoglycemia (HP:0001998)1.86493708
107Abnormality of the renal collecting system (HP:0004742)1.86057418
108Recurrent abscess formation (HP:0002722)1.86045316
109Aneurysm (HP:0002617)1.86020434
110Periodontitis (HP:0000704)1.85233827
111Acute myeloid leukemia (HP:0004808)1.85085519
112Encephalitis (HP:0002383)1.84442491
113Gingivitis (HP:0000230)1.84134870
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.83836604
115Ectropion (HP:0000656)1.83747991
116Abnormality of incisor morphology (HP:0011063)1.82874159
117Thick nail (HP:0001805)1.82239731
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81752965
119Impulsivity (HP:0100710)1.80293948
120Vacuolated lymphocytes (HP:0001922)1.79841685
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79731751
122Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79549214
123Reduced antithrombin III activity (HP:0001976)1.79157209
124Drooling (HP:0002307)1.79072102
125Excessive salivation (HP:0003781)1.79072102
126Deep venous thrombosis (HP:0002625)1.78871139
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.78810334
128Micronodular cirrhosis (HP:0001413)1.78171125
129Advanced eruption of teeth (HP:0006288)1.78030001
130Increased connective tissue (HP:0009025)1.77708721
131Long eyelashes (HP:0000527)1.75629392
132Abnormality of the ileum (HP:0001549)1.75538378
133Vertebral arch anomaly (HP:0008438)1.75409895
134Intellectual disability, progressive (HP:0006887)1.75336718
135Low anterior hairline (HP:0000294)1.74506941
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73737414
137Spondylolisthesis (HP:0003302)1.73278876
138Insidious onset (HP:0003587)1.73184273
139Termporal pattern (HP:0011008)1.73184273
140Gastrointestinal inflammation (HP:0004386)1.72999677
141Anal stenosis (HP:0002025)1.71969447
142Gastrointestinal infarctions (HP:0005244)1.70955949
143Vasculitis (HP:0002633)1.70025324
144Right ventricular cardiomyopathy (HP:0011663)1.69749531
145Fatigue (HP:0012378)1.69397184
146Osteomalacia (HP:0002749)1.69040340
147Gingival bleeding (HP:0000225)1.68558586
148Supernumerary bones of the axial skeleton (HP:0009144)1.68511700
149Leukopenia (HP:0001882)1.68265870
150Abnormal platelet volume (HP:0011876)1.68049951
151Depressed nasal tip (HP:0000437)1.67505384
152Abnormality of T cell physiology (HP:0011840)1.66542889
153Recurrent bronchitis (HP:0002837)1.66376777
154Dry hair (HP:0011359)1.66256300
155Nonprogressive disorder (HP:0003680)1.66189676
156Supernumerary ribs (HP:0005815)1.65683766
157Abnormality of DNA repair (HP:0003254)1.65120216
158Recurrent pneumonia (HP:0006532)1.64904280
159Stomach cancer (HP:0012126)1.64886051
160Attenuation of retinal blood vessels (HP:0007843)1.64528416
161Prolonged bleeding time (HP:0003010)1.63519873
162Mitral valve prolapse (HP:0001634)1.63158863
163Increased mean platelet volume (HP:0011877)1.62934043
164Broad palm (HP:0001169)1.62308670
165Bronchiectasis (HP:0002110)1.62216905
166Abnormal foot bone ossification (HP:0010675)1.61829229
167Urethral obstruction (HP:0000796)1.61230403
168Myocardial infarction (HP:0001658)1.61174163
169Malignant gastrointestinal tract tumors (HP:0006749)1.60926771
170Gastrointestinal carcinoma (HP:0002672)1.60926771
171Overgrowth (HP:0001548)1.59728006
172Protrusio acetabuli (HP:0003179)1.59619110
173Esophageal varix (HP:0002040)1.58855987
174Craniofacial hyperostosis (HP:0004493)1.58678885
175Dilatation of the ascending aorta (HP:0005111)1.58345706
176Uterine leiomyosarcoma (HP:0002891)1.57621632
177Leiomyosarcoma (HP:0100243)1.57621632
178Epistaxis (HP:0000421)1.57516097
179Transitional cell carcinoma of the bladder (HP:0006740)1.57438693
180Menstrual irregularities (HP:0000858)1.56977128
181Glucose intolerance (HP:0000833)1.56598667
182Cranial hyperostosis (HP:0004437)1.54557332
183Bladder carcinoma (HP:0002862)1.54243811
184Bladder neoplasm (HP:0009725)1.54243811
185Acanthocytosis (HP:0001927)1.54157829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.34101678
2PRKD23.32957056
3TLK13.00869655
4CLK12.88386469
5IRAK42.77023411
6IRAK32.67252188
7STK382.56224023
8CASK2.50699367
9FGFR42.27597264
10PRPF4B2.23850450
11MAPK152.19378851
12TSSK62.16552867
13BRD42.12753721
14CDK122.11605674
15NLK2.06717363
16ICK2.05859104
17SMG11.98458470
18MAP4K11.93897356
19EEF2K1.91730807
20TAOK31.79424637
21ZAK1.76398117
22HIPK21.75203806
23TRIB31.72303429
24MAP3K101.71510366
25SRPK11.69325990
26MAP3K131.68287968
27MAP3K21.66205977
28IRAK11.64957816
29MST41.62613769
30LATS11.61885595
31YES11.61352118
32ERN11.61329477
33TTN1.60320362
34AKT31.60263968
35IRAK21.58531878
36TNIK1.52394990
37TEC1.48931044
38MKNK21.48804693
39PDGFRA1.45709881
40TRPM71.44803140
41MAP3K141.44444324
42VRK11.36693687
43PDGFRB1.35449600
44RIPK41.33252971
45INSRR1.33110745
46SCYL21.30078833
47IKBKE1.29515588
48ITK1.26219994
49MAP2K31.23963176
50PIM11.23946587
51MST1R1.23667934
52JAK31.19122004
53SGK31.18965836
54MTOR1.17097404
55EIF2AK21.15809943
56STK41.12166449
57KSR21.08764408
58STK111.07228334
59RIPK11.05638457
60STK101.05527322
61NUAK11.04902546
62CSK1.04557712
63GRK61.02436451
64EPHB11.01154700
65LCK1.00193634
66STK390.99412283
67BTK0.99397296
68BLK0.98895991
69IKBKB0.98110348
70MKNK10.94139571
71FRK0.92851158
72STK240.90237426
73PKN20.89460956
74CDK40.84674156
75FGR0.84529828
76RPS6KA50.83549218
77SIK10.83383260
78MAP3K10.83079001
79MAPK110.81585430
80EPHA30.81536245
81CDK30.81526600
82FGFR30.81368246
83GRK70.80489407
84RET0.78350387
85TGFBR20.78244260
86CDC70.77149221
87PRKAA20.74448290
88RPS6KB20.74334458
89HCK0.72424864
90MARK20.71920890
91PDK10.71059426
92MAP3K70.70818562
93LYN0.70724904
94NEK60.70154734
95DMPK0.69554981
96MAP3K30.69473089
97JAK20.67693543
98KIT0.66826469
99FGFR10.66773258
100JAK10.66346427
101MET0.65151918
102CDK90.64040262
103WNK10.63113952
104SGK20.62210865
105PRKCQ0.62006166
106PDPK10.61664933
107NME20.61337641
108CHEK10.60135454
109ADRBK20.60085680
110EIF2AK30.59833873
111CDK70.58498700
112CSF1R0.58029402
113ATR0.57707188
114UHMK10.57594028
115BRSK20.56722601
116CHUK0.56522714
117CDC42BPA0.55997970
118SYK0.53824627
119ZAP700.53677794
120RPS6KB10.52553139
121TNK20.51884913
122RAF10.51770349
123FGFR20.51761918
124DYRK30.51741780
125MAPK70.51365789
126BMPR20.50538104
127GRK10.50331705
128ATM0.50309661
129KSR10.50165493
130PKN10.50132118
131CDK60.49810348
132LATS20.49518236
133NEK90.48574494
134MAPKAPK50.47587995
135CSNK1G10.47201713
136CAMK1D0.46825745
137PTK20.46595422
138MAP3K60.46246804
139MELK0.45264530
140PLK40.44767389
141DYRK1B0.44630776
142MARK30.43958404
143FES0.43786610
144CSNK1A1L0.43616801
145MAP3K80.43406229
146PRKD10.42441907
147EIF2AK10.41982974
148PAK40.41857713
149STK30.40463924
150PIK3CG0.38372041
151ABL10.37795100
152TYK20.37187301
153PIK3CA0.36579177
154CAMK1G0.35577229

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.83222277
2Fanconi anemia pathway_Homo sapiens_hsa034602.37104489
3Graft-versus-host disease_Homo sapiens_hsa053322.33526623
4Non-small cell lung cancer_Homo sapiens_hsa052232.22039607
5Measles_Homo sapiens_hsa051622.21737075
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.18844594
7Antigen processing and presentation_Homo sapiens_hsa046122.17919188
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.13275324
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00643746
10Pancreatic cancer_Homo sapiens_hsa052121.97767833
11Non-homologous end-joining_Homo sapiens_hsa034501.96598856
12Hematopoietic cell lineage_Homo sapiens_hsa046401.88362004
13Protein export_Homo sapiens_hsa030601.87122701
14Ribosome_Homo sapiens_hsa030101.86985152
15Homologous recombination_Homo sapiens_hsa034401.85937901
16T cell receptor signaling pathway_Homo sapiens_hsa046601.83654179
17Systemic lupus erythematosus_Homo sapiens_hsa053221.76377955
18Renal cell carcinoma_Homo sapiens_hsa052111.74684861
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70187849
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68977360
21Allograft rejection_Homo sapiens_hsa053301.68644354
22Ether lipid metabolism_Homo sapiens_hsa005651.53906876
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46149165
24Herpes simplex infection_Homo sapiens_hsa051681.45870252
25Basal transcription factors_Homo sapiens_hsa030221.45465249
26Spliceosome_Homo sapiens_hsa030401.44019144
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43474682
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.42757524
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.42475951
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42429407
31mTOR signaling pathway_Homo sapiens_hsa041501.38665632
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37562915
33Dorso-ventral axis formation_Homo sapiens_hsa043201.34497387
34Other glycan degradation_Homo sapiens_hsa005111.34088317
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32508330
36Sphingolipid metabolism_Homo sapiens_hsa006001.32432564
37B cell receptor signaling pathway_Homo sapiens_hsa046621.32069985
38Proteoglycans in cancer_Homo sapiens_hsa052051.30926296
39DNA replication_Homo sapiens_hsa030301.30381138
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23527782
41Focal adhesion_Homo sapiens_hsa045101.22364045
42Glioma_Homo sapiens_hsa052141.22273491
43Acute myeloid leukemia_Homo sapiens_hsa052211.22063679
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20544476
45Prolactin signaling pathway_Homo sapiens_hsa049171.18739669
46Prostate cancer_Homo sapiens_hsa052151.17848745
47ErbB signaling pathway_Homo sapiens_hsa040121.16841486
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16763601
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16704629
50Autoimmune thyroid disease_Homo sapiens_hsa053201.14759902
51Leishmaniasis_Homo sapiens_hsa051401.12780226
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.12627919
53One carbon pool by folate_Homo sapiens_hsa006701.12023026
54Malaria_Homo sapiens_hsa051441.09515404
55Insulin resistance_Homo sapiens_hsa049311.09276693
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09190165
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.06442983
58Osteoclast differentiation_Homo sapiens_hsa043801.05991431
59Bladder cancer_Homo sapiens_hsa052191.01733525
60Thyroid cancer_Homo sapiens_hsa052161.01237565
61VEGF signaling pathway_Homo sapiens_hsa043701.00393417
62Mismatch repair_Homo sapiens_hsa034300.99246127
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98940459
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.97720490
65Influenza A_Homo sapiens_hsa051640.97159772
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95209660
67Inositol phosphate metabolism_Homo sapiens_hsa005620.94913925
68Insulin signaling pathway_Homo sapiens_hsa049100.93441330
69mRNA surveillance pathway_Homo sapiens_hsa030150.93336465
70Phototransduction_Homo sapiens_hsa047440.87200909
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86093465
72HIF-1 signaling pathway_Homo sapiens_hsa040660.84570045
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84113088
74Amoebiasis_Homo sapiens_hsa051460.83450075
75Circadian rhythm_Homo sapiens_hsa047100.83195491
76Small cell lung cancer_Homo sapiens_hsa052220.81960175
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81760677
78RNA degradation_Homo sapiens_hsa030180.81209213
79Viral carcinogenesis_Homo sapiens_hsa052030.81135245
80Lysine degradation_Homo sapiens_hsa003100.78715373
81Nucleotide excision repair_Homo sapiens_hsa034200.78283951
82Toxoplasmosis_Homo sapiens_hsa051450.77473314
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.77437459
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77016449
85Hepatitis B_Homo sapiens_hsa051610.76390982
86p53 signaling pathway_Homo sapiens_hsa041150.75940151
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.75876098
88Estrogen signaling pathway_Homo sapiens_hsa049150.75682994
89Basal cell carcinoma_Homo sapiens_hsa052170.74773654
90Fatty acid biosynthesis_Homo sapiens_hsa000610.74730824
91MicroRNAs in cancer_Homo sapiens_hsa052060.74351787
92Epstein-Barr virus infection_Homo sapiens_hsa051690.73995490
93GnRH signaling pathway_Homo sapiens_hsa049120.73773222
94Chemokine signaling pathway_Homo sapiens_hsa040620.73690033
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73281064
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.72341173
97Asthma_Homo sapiens_hsa053100.71793815
98Cell cycle_Homo sapiens_hsa041100.71327399
99ECM-receptor interaction_Homo sapiens_hsa045120.71325343
100RNA polymerase_Homo sapiens_hsa030200.71194946
101Legionellosis_Homo sapiens_hsa051340.70280551
102Base excision repair_Homo sapiens_hsa034100.70158648
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69068136
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67349423
105Melanoma_Homo sapiens_hsa052180.67038098
106Wnt signaling pathway_Homo sapiens_hsa043100.65005695
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64900653
108Long-term potentiation_Homo sapiens_hsa047200.64738262
109Apoptosis_Homo sapiens_hsa042100.62799274
110ABC transporters_Homo sapiens_hsa020100.61384325
111Colorectal cancer_Homo sapiens_hsa052100.61285942
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61271078
113Complement and coagulation cascades_Homo sapiens_hsa046100.61092738
114Alcoholism_Homo sapiens_hsa050340.60718129
115Hepatitis C_Homo sapiens_hsa051600.60496706
116Type I diabetes mellitus_Homo sapiens_hsa049400.58433346
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57910213
118HTLV-I infection_Homo sapiens_hsa051660.56873582
119Pyrimidine metabolism_Homo sapiens_hsa002400.55708908
120MAPK signaling pathway_Homo sapiens_hsa040100.55390914
121TGF-beta signaling pathway_Homo sapiens_hsa043500.54700290
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53240269
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53029501
124Linoleic acid metabolism_Homo sapiens_hsa005910.52677906
125Choline metabolism in cancer_Homo sapiens_hsa052310.52333977
126AMPK signaling pathway_Homo sapiens_hsa041520.51524352
127Adherens junction_Homo sapiens_hsa045200.51510876
128Type II diabetes mellitus_Homo sapiens_hsa049300.51350950
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51131690
130Platelet activation_Homo sapiens_hsa046110.50735082
131Staphylococcus aureus infection_Homo sapiens_hsa051500.50238785
132Notch signaling pathway_Homo sapiens_hsa043300.49786039
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49193663
134Arachidonic acid metabolism_Homo sapiens_hsa005900.48940902
135Pathways in cancer_Homo sapiens_hsa052000.48027757
136TNF signaling pathway_Homo sapiens_hsa046680.44470788
137Endometrial cancer_Homo sapiens_hsa052130.44437873
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44426916
139Tuberculosis_Homo sapiens_hsa051520.43905759
140Rheumatoid arthritis_Homo sapiens_hsa053230.43512618
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41283388
142FoxO signaling pathway_Homo sapiens_hsa040680.40830594
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38932687
144Chronic myeloid leukemia_Homo sapiens_hsa052200.38680775
145Pertussis_Homo sapiens_hsa051330.37648873
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33518395
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.32146326

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