ASZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex assembly (GO:0007130)9.30073433
2* DNA methylation involved in gamete generation (GO:0043046)8.63384016
3synaptonemal complex organization (GO:0070193)8.61389771
4regulation of meiosis I (GO:0060631)6.88198661
5chromosome organization involved in meiosis (GO:0070192)6.65617001
6* male meiosis (GO:0007140)6.52219521
7* meiotic nuclear division (GO:0007126)6.41878198
8male meiosis I (GO:0007141)6.20576847
9meiotic chromosome segregation (GO:0045132)5.92479978
10attachment of spindle microtubules to kinetochore (GO:0008608)5.73696008
11meiosis I (GO:0007127)5.49711665
12meiotic cell cycle process (GO:1903046)5.27320833
13mitotic metaphase plate congression (GO:0007080)4.97272290
14negative regulation of meiosis (GO:0045835)4.93997781
15reciprocal meiotic recombination (GO:0007131)4.89703487
16reciprocal DNA recombination (GO:0035825)4.89703487
17oogenesis (GO:0048477)4.86518045
18oocyte maturation (GO:0001556)4.70189733
19mitotic chromosome condensation (GO:0007076)4.69728492
20female gamete generation (GO:0007292)4.63746681
21DNA replication checkpoint (GO:0000076)4.60076229
22* gene silencing by RNA (GO:0031047)4.57360226
23metaphase plate congression (GO:0051310)4.50763551
24* DNA methylation (GO:0006306)4.39565119
25* DNA alkylation (GO:0006305)4.39565119
26positive regulation of meiosis (GO:0045836)4.37469997
27resolution of meiotic recombination intermediates (GO:0000712)4.37066455
28meiotic cell cycle (GO:0051321)4.36779270
29sister chromatid cohesion (GO:0007062)4.34223834
30kinetochore organization (GO:0051383)4.33517715
31kinetochore assembly (GO:0051382)4.19767840
32positive regulation of meiotic cell cycle (GO:0051446)4.19202513
33chromatin remodeling at centromere (GO:0031055)4.18576769
34DNA synthesis involved in DNA repair (GO:0000731)4.16072832
35protein K6-linked ubiquitination (GO:0085020)4.13480098
36regulation of meiosis (GO:0040020)4.12486674
37histone exchange (GO:0043486)4.04890192
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.99439210
39protein K11-linked deubiquitination (GO:0035871)3.99345603
40nuclear pore organization (GO:0006999)3.91464312
41nuclear pore complex assembly (GO:0051292)3.87342666
42DNA replication-dependent nucleosome organization (GO:0034723)3.81344650
43DNA replication-dependent nucleosome assembly (GO:0006335)3.81344650
44platelet dense granule organization (GO:0060155)3.80946389
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78282516
46CENP-A containing nucleosome assembly (GO:0034080)3.78190524
47spindle checkpoint (GO:0031577)3.78061162
48regulation of chromosome segregation (GO:0051983)3.77426323
49positive regulation of translational initiation (GO:0045948)3.74758503
50mitotic spindle checkpoint (GO:0071174)3.74675797
51establishment of chromosome localization (GO:0051303)3.74243004
52mitotic spindle assembly checkpoint (GO:0007094)3.72718548
53DNA replication-independent nucleosome organization (GO:0034724)3.72387725
54DNA replication-independent nucleosome assembly (GO:0006336)3.72387725
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71111717
56negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.71077237
57indole-containing compound catabolic process (GO:0042436)3.69830805
58indolalkylamine catabolic process (GO:0046218)3.69830805
59tryptophan catabolic process (GO:0006569)3.69830805
60negative regulation of chromosome segregation (GO:0051985)3.69509484
61behavioral response to nicotine (GO:0035095)3.69290026
62DNA deamination (GO:0045006)3.68736784
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.67698147
64negative regulation of sister chromatid segregation (GO:0033046)3.67698147
65negative regulation of mitotic sister chromatid separation (GO:2000816)3.67698147
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.67698147
67spindle assembly checkpoint (GO:0071173)3.65971464
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.60410236
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59060141
70indolalkylamine metabolic process (GO:0006586)3.58991167
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.57568911
72axoneme assembly (GO:0035082)3.57493539
73mitotic nuclear envelope disassembly (GO:0007077)3.54929208
74chromosome segregation (GO:0007059)3.52044694
75mitotic sister chromatid segregation (GO:0000070)3.49988873
76regulation of glucokinase activity (GO:0033131)3.49314421
77regulation of hexokinase activity (GO:1903299)3.49314421
78protein localization to kinetochore (GO:0034501)3.47104330
79positive regulation of chromosome segregation (GO:0051984)3.47070370
80cilium or flagellum-dependent cell motility (GO:0001539)3.46497819
81binding of sperm to zona pellucida (GO:0007339)3.46049661
82regulation of mitotic sister chromatid separation (GO:0010965)3.45468292
83regulation of mitotic sister chromatid segregation (GO:0033047)3.45468292
84regulation of sister chromatid segregation (GO:0033045)3.45468292
85response to pheromone (GO:0019236)3.43112768
86synapsis (GO:0007129)3.40431325
87mitotic sister chromatid cohesion (GO:0007064)3.40374215
88negative regulation of nuclear division (GO:0051784)3.39369412
89oocyte development (GO:0048599)3.37315443
90* DNA methylation or demethylation (GO:0044728)3.37116327
91nuclear envelope disassembly (GO:0051081)3.36368835
92membrane disassembly (GO:0030397)3.36368835
93tryptophan metabolic process (GO:0006568)3.36336901
94* gene silencing (GO:0016458)3.29150890
95protein localization to chromosome (GO:0034502)3.28949097
96heterochromatin organization (GO:0070828)3.28119513
97chromosome organization (GO:0051276)3.28084535
98regulation of meiotic cell cycle (GO:0051445)3.27397828
99kynurenine metabolic process (GO:0070189)3.26814624
100* nuclear division (GO:0000280)3.24732413
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.23739610
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23739610
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23739610
104regulation of sister chromatid cohesion (GO:0007063)3.22916346
105regulation of spindle organization (GO:0090224)3.22677188
106histone H2A monoubiquitination (GO:0035518)3.22450634
107ribosome assembly (GO:0042255)3.22025863
108protein localization to chromosome, centromeric region (GO:0071459)3.21250119
109proteasome assembly (GO:0043248)3.20175668
110DNA damage induced protein phosphorylation (GO:0006975)3.17802515
111photoreceptor cell maintenance (GO:0045494)3.15484249
112regulation of mitotic spindle checkpoint (GO:1903504)3.13829667
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13829667
114regulation of centriole replication (GO:0046599)3.12667286
115maturation of 5.8S rRNA (GO:0000460)3.12198775
116DNA replication initiation (GO:0006270)3.11815781
117regulation of centrosome cycle (GO:0046605)3.11457858
118* DNA modification (GO:0006304)3.11335940
119respiratory chain complex IV assembly (GO:0008535)3.11185893
120negative regulation of meiotic cell cycle (GO:0051447)3.10756802
121fucose catabolic process (GO:0019317)3.10201982
122L-fucose metabolic process (GO:0042354)3.10201982
123L-fucose catabolic process (GO:0042355)3.10201982
124epithelial cilium movement (GO:0003351)3.08075601
125amine catabolic process (GO:0009310)3.03337960
126cellular biogenic amine catabolic process (GO:0042402)3.03337960
127cytochrome complex assembly (GO:0017004)2.99926088
128retinal cone cell development (GO:0046549)2.98332254
129protein polyglutamylation (GO:0018095)2.97083986
130regulation of cilium movement (GO:0003352)2.92325271
131protein localization to cilium (GO:0061512)2.90987629
132cellular ketone body metabolic process (GO:0046950)2.89886138
133mannosylation (GO:0097502)2.83162430
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.81698221
135behavioral response to ethanol (GO:0048149)2.79892535
136phosphatidylinositol acyl-chain remodeling (GO:0036149)2.75896003
137neural tube formation (GO:0001841)2.74607066
138preassembly of GPI anchor in ER membrane (GO:0016254)2.72329188
139dopamine transport (GO:0015872)2.72236724
140detection of light stimulus involved in sensory perception (GO:0050962)2.71589700
141detection of light stimulus involved in visual perception (GO:0050908)2.71589700
142reflex (GO:0060004)2.71577203
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70571320
144auditory receptor cell stereocilium organization (GO:0060088)2.69989916
145cilium morphogenesis (GO:0060271)2.69771166
146photoreceptor cell development (GO:0042461)2.67664110
147positive regulation of mitochondrial fission (GO:0090141)2.67279593
148inositol phosphate catabolic process (GO:0071545)2.66059262
149negative regulation of telomere maintenance (GO:0032205)2.65010224
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63979498
151tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63979498
152rRNA catabolic process (GO:0016075)2.63750067
153protein complex biogenesis (GO:0070271)2.62467107
154positive regulation of fatty acid transport (GO:2000193)2.61943878
155indole-containing compound metabolic process (GO:0042430)2.61135089
156ketone body metabolic process (GO:1902224)2.60915965
157organic cation transport (GO:0015695)2.60855610
158centriole replication (GO:0007099)2.59991962
159DNA double-strand break processing (GO:0000729)2.59845214
160negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59337887
161negative regulation of translation, ncRNA-mediated (GO:0040033)2.59337887
162regulation of translation, ncRNA-mediated (GO:0045974)2.59337887
163regulation of microtubule-based movement (GO:0060632)2.58791808
164water-soluble vitamin biosynthetic process (GO:0042364)2.56439611
165recombinational repair (GO:0000725)2.53003599
166proline transport (GO:0015824)2.52618163
167double-strand break repair via homologous recombination (GO:0000724)2.52110914
168L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51462593
169synaptic transmission, cholinergic (GO:0007271)2.50696996
170sperm motility (GO:0030317)2.49224114
171inositol phosphate dephosphorylation (GO:0046855)2.48443045
172phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48443045
173somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47957684
174somatic hypermutation of immunoglobulin genes (GO:0016446)2.47957684
175positive regulation of prostaglandin secretion (GO:0032308)2.47880022
176establishment of protein localization to Golgi (GO:0072600)2.46913413
177* piRNA metabolic process (GO:0034587)11.5019999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.84127055
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.73355423
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.03075581
4ZNF274_21170338_ChIP-Seq_K562_Hela3.90749110
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.81562970
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79926917
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.44970790
8AR_21909140_ChIP-Seq_LNCAP_Human3.35859784
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.35672046
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16071148
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06600194
12IGF1R_20145208_ChIP-Seq_DFB_Human3.04621330
13VDR_22108803_ChIP-Seq_LS180_Human2.90594042
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69486035
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.66831168
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61701884
17EZH2_22144423_ChIP-Seq_EOC_Human2.61261967
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59519201
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54809272
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52454346
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.47741330
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45006410
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.41135839
24GBX2_23144817_ChIP-Seq_PC3_Human2.40788329
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.37868889
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29012231
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.28824753
28FUS_26573619_Chip-Seq_HEK293_Human2.23435775
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23072549
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.20007445
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18894487
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17892922
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16575345
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14793753
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04284411
36MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03646637
37ER_23166858_ChIP-Seq_MCF-7_Human2.03381335
38RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02171759
39TAF15_26573619_Chip-Seq_HEK293_Human2.01492661
40* P300_19829295_ChIP-Seq_ESCs_Human1.99834129
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97746744
42CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95714547
43EWS_26573619_Chip-Seq_HEK293_Human1.95574654
44VDR_23849224_ChIP-Seq_CD4+_Human1.95181019
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93425553
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92599686
47GABP_19822575_ChIP-Seq_HepG2_Human1.87548418
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86801239
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83891962
50DCP1A_22483619_ChIP-Seq_HELA_Human1.81230764
51* BCAT_22108803_ChIP-Seq_LS180_Human1.74130456
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67505498
53TP53_22573176_ChIP-Seq_HFKS_Human1.65567008
54XRN2_22483619_ChIP-Seq_HELA_Human1.62649627
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60397684
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60090367
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.58764177
58* STAT3_23295773_ChIP-Seq_U87_Human1.58374475
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56589585
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56422436
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56297868
62FOXP3_21729870_ChIP-Seq_TREG_Human1.56007074
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55693500
64KDM5A_27292631_Chip-Seq_BREAST_Human1.53917870
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53867120
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53166593
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49864067
68* TCF4_23295773_ChIP-Seq_U87_Human1.48326375
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48268688
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47404806
71TTF2_22483619_ChIP-Seq_HELA_Human1.45924005
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45334556
73SMAD4_21799915_ChIP-Seq_A2780_Human1.44227154
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43724769
75* AR_25329375_ChIP-Seq_VCAP_Human1.42824881
76* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40932655
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40650021
78CBP_20019798_ChIP-Seq_JUKART_Human1.40302186
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40302186
80IRF1_19129219_ChIP-ChIP_H3396_Human1.40056596
81* SOX2_19829295_ChIP-Seq_ESCs_Human1.38435267
82* NANOG_19829295_ChIP-Seq_ESCs_Human1.38435267
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38233460
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37690140
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.36889989
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35751646
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.34897938
88* FOXA1_25329375_ChIP-Seq_VCAP_Human1.34520496
89* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34520496
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34255360
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33899705
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33688287
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32322421
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32035433
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29723079
96* TCF4_22108803_ChIP-Seq_LS180_Human1.28349102
97RUNX2_22187159_ChIP-Seq_PCA_Human1.27676021
98MYC_18940864_ChIP-ChIP_HL60_Human1.26627886
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26559479
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26309522
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25026224
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.24182015
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23411277
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23011240
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.22911937
106AR_20517297_ChIP-Seq_VCAP_Human1.22575578
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21133767
108BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20512221
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19537691
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19537691
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19537691
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19219770
113HOXB7_26014856_ChIP-Seq_BT474_Human1.19211886
114NCOR_22424771_ChIP-Seq_293T_Human1.17740956
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17525329
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16042316
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16028871
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15436888
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15436888
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.14974685
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14388759
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.14384332
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.11803603
124* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11198063
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.11178856
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11088928
127RNF2_27304074_Chip-Seq_NSC_Mouse1.10393975
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.09615626
129* CDX2_22108803_ChIP-Seq_LS180_Human1.09417757
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09358695
131CIITA_25753668_ChIP-Seq_RAJI_Human1.08545322
132GATA3_21878914_ChIP-Seq_MCF-7_Human1.07683673
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.07585891
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.07218249
135P53_22387025_ChIP-Seq_ESCs_Mouse1.06837220
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06233858
137AR_21572438_ChIP-Seq_LNCaP_Human1.05652793
138RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05543323
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04969284
140FLI1_27457419_Chip-Seq_LIVER_Mouse1.04768121
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03758413
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02530425
143REST_21632747_ChIP-Seq_MESCs_Mouse1.02340929
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02185156
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01971666
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99751246
147ELK1_19687146_ChIP-ChIP_HELA_Human0.99402997
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99330428
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.98720714
150MYC_19829295_ChIP-Seq_ESCs_Human0.98012044
151CBX2_27304074_Chip-Seq_ESCs_Mouse0.97201930
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96882422
153DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95174685
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93050202
155TP63_19390658_ChIP-ChIP_HaCaT_Human0.91759957
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91620163
157NANOG_21062744_ChIP-ChIP_HESCs_Human0.91167543
158HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88113944
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87224858
160GATA3_21867929_ChIP-Seq_TH1_Mouse0.87173847
161SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85423241
162NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83729766
163TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83228638
164TFEB_21752829_ChIP-Seq_HELA_Human0.82366478
165TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.82199999
166NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81490067
167SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79562525
168ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79373413
169CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78605728
170SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77386234
171PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74857272
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71970778
173NOTCH1_21737748_ChIP-Seq_TLL_Human0.70254806
174SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69873701
175SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.67481490
176EGR1_19374776_ChIP-ChIP_THP-1_Human0.67214636
177ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.66043874
178SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65397974
179FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64546065
180RBPJ_21746931_ChIP-Seq_IB4_Human0.63948367
181PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.62665137
182STAT1_17558387_ChIP-Seq_HELA_Human0.61971116
183ETV1_20927104_ChIP-Seq_GIST48_Human0.60102892
184REST_19997604_ChIP-ChIP_NEURONS_Mouse0.59471831
185FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58459252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008877_abnormal_DNA_methylation6.19511236
2MP0003693_abnormal_embryo_hatching4.84546734
3MP0008995_early_reproductive_senescence4.28372970
4* MP0002210_abnormal_sex_determination4.19488963
5MP0003111_abnormal_nucleus_morphology4.19428116
6MP0003718_maternal_effect3.99052457
7* MP0010094_abnormal_chromosome_stability3.98883547
8* MP0001929_abnormal_gametogenesis3.93882773
9MP0008058_abnormal_DNA_repair3.74749367
10MP0004957_abnormal_blastocyst_morpholog3.64049226
11MP0003786_premature_aging3.60858353
12MP0003077_abnormal_cell_cycle3.50153012
13MP0003195_calcinosis3.40946233
14* MP0001145_abnormal_male_reproductive3.31038605
15* MP0000653_abnormal_sex_gland3.28427332
16MP0008057_abnormal_DNA_replication3.23738194
17MP0003123_paternal_imprinting3.12612320
18* MP0003698_abnormal_male_reproductive2.78350653
19MP0001986_abnormal_taste_sensitivity2.48748821
20MP0003646_muscle_fatigue2.46968486
21MP0008932_abnormal_embryonic_tissue2.42568581
22MP0005551_abnormal_eye_electrophysiolog2.42494893
23MP0005646_abnormal_pituitary_gland2.34945894
24MP0001119_abnormal_female_reproductive2.32007484
25MP0001968_abnormal_touch/_nociception2.18310486
26MP0002876_abnormal_thyroid_physiology2.13719332
27MP0008007_abnormal_cellular_replicative2.10195396
28MP0001730_embryonic_growth_arrest2.07529511
29MP0008875_abnormal_xenobiotic_pharmacok2.05955240
30* MP0002161_abnormal_fertility/fecundity2.04551493
31MP0000372_irregular_coat_pigmentation2.01216343
32MP0005410_abnormal_fertilization2.00620504
33MP0003699_abnormal_female_reproductive1.95829562
34MP0008872_abnormal_physiological_respon1.95724464
35MP0003315_abnormal_perineum_morphology1.90850821
36MP0005645_abnormal_hypothalamus_physiol1.90477018
37MP0001984_abnormal_olfaction1.78988283
38MP0005253_abnormal_eye_physiology1.76917406
39MP0004043_abnormal_pH_regulation1.73441230
40MP0000350_abnormal_cell_proliferation1.72977449
41MP0002837_dystrophic_cardiac_calcinosis1.67016994
42MP0001501_abnormal_sleep_pattern1.66756199
43MP0002638_abnormal_pupillary_reflex1.66011163
44MP0008260_abnormal_autophagy1.64739776
45MP0009745_abnormal_behavioral_response1.64226194
46MP0006072_abnormal_retinal_apoptosis1.63970888
47MP0005395_other_phenotype1.63027783
48MP0009046_muscle_twitch1.61676338
49MP0002736_abnormal_nociception_after1.61673707
50MP0001486_abnormal_startle_reflex1.60343356
51MP0006276_abnormal_autonomic_nervous1.58253713
52MP0004147_increased_porphyrin_level1.54794172
53MP0003121_genomic_imprinting1.54350908
54MP0004142_abnormal_muscle_tone1.48369632
55MP0005451_abnormal_body_composition1.48052862
56MP0000569_abnormal_digit_pigmentation1.46608151
57MP0002160_abnormal_reproductive_system1.45338073
58MP0005174_abnormal_tail_pigmentation1.41930332
59MP0002928_abnormal_bile_duct1.41270246
60MP0002272_abnormal_nervous_system1.40405639
61MP0005380_embryogenesis_phenotype1.37149851
62MP0001672_abnormal_embryogenesis/_devel1.37149851
63MP0000631_abnormal_neuroendocrine_gland1.36750944
64MP0005084_abnormal_gallbladder_morpholo1.35281674
65MP0008789_abnormal_olfactory_epithelium1.34272488
66MP0002653_abnormal_ependyma_morphology1.32823318
67MP0001697_abnormal_embryo_size1.32475615
68MP0001764_abnormal_homeostasis1.31715727
69MP0002085_abnormal_embryonic_tissue1.31658691
70MP0003136_yellow_coat_color1.31524517
71MP0005389_reproductive_system_phenotype1.25302721
72MP0002277_abnormal_respiratory_mucosa1.23028181
73MP0003890_abnormal_embryonic-extraembry1.22360326
74MP0005167_abnormal_blood-brain_barrier1.21037611
75MP0010307_abnormal_tumor_latency1.20155634
76MP0002138_abnormal_hepatobiliary_system1.17834175
77MP0010352_gastrointestinal_tract_polyps1.16521317
78MP0003937_abnormal_limbs/digits/tail_de1.15979393
79MP0002572_abnormal_emotion/affect_behav1.13300394
80MP0006035_abnormal_mitochondrial_morpho1.13214022
81MP0002084_abnormal_developmental_patter1.12233615
82MP0003984_embryonic_growth_retardation1.11136826
83MP0005310_abnormal_salivary_gland1.10824781
84MP0000015_abnormal_ear_pigmentation1.06743285
85MP0000313_abnormal_cell_death1.06722055
86MP0002019_abnormal_tumor_incidence1.06695964
87MP0002080_prenatal_lethality1.05838526
88MP0003011_delayed_dark_adaptation1.05334580
89MP0004885_abnormal_endolymph1.05291551
90MP0002088_abnormal_embryonic_growth/wei1.05084877
91MP0004145_abnormal_muscle_electrophysio1.04935000
92MP0001502_abnormal_circadian_rhythm1.04708610
93MP0003787_abnormal_imprinting1.03456704
94MP0001485_abnormal_pinna_reflex1.02326144
95MP0005075_abnormal_melanosome_morpholog1.01916856
96MP0002909_abnormal_adrenal_gland1.01057713
97MP0002064_seizures0.99034113
98MP0004133_heterotaxia0.98549943
99MP0001970_abnormal_pain_threshold0.97298444
100MP0003880_abnormal_central_pattern0.96997136
101MP0005386_behavior/neurological_phenoty0.95364313
102MP0004924_abnormal_behavior0.95364313
103MP0004215_abnormal_myocardial_fiber0.93927418
104MP0004808_abnormal_hematopoietic_stem0.92924817
105MP0005379_endocrine/exocrine_gland_phen0.91615918
106MP0000230_abnormal_systemic_arterial0.91464070
107MP0002733_abnormal_thermal_nociception0.91167430
108MP0002557_abnormal_social/conspecific_i0.91088000
109MP0000579_abnormal_nail_morphology0.90892108
110MP0002163_abnormal_gland_morphology0.89598772
111MP0003252_abnormal_bile_duct0.89544210
112MP0002095_abnormal_skin_pigmentation0.88699819
113MP0002229_neurodegeneration0.87012757
114MP0002735_abnormal_chemical_nociception0.86598069
115MP0001919_abnormal_reproductive_system0.86162737
116MP0005085_abnormal_gallbladder_physiolo0.86152334
117MP0004742_abnormal_vestibular_system0.85447583
118MP0002067_abnormal_sensory_capabilities0.82143437
119MP0006292_abnormal_olfactory_placode0.80877205
120MP0002086_abnormal_extraembryonic_tissu0.79840101
121MP0005195_abnormal_posterior_eye0.79568575
122MP0003941_abnormal_skin_development0.79387139
123MP0009672_abnormal_birth_weight0.79304039
124MP0003567_abnormal_fetal_cardiomyocyte0.77449733
125MP0005671_abnormal_response_to0.75985984
126MP0003635_abnormal_synaptic_transmissio0.75555141
127MP0002063_abnormal_learning/memory/cond0.75110142
128MP0005621_abnormal_cell_physiology0.74765412
129MP0005423_abnormal_somatic_nervous0.73407063
130MP0004197_abnormal_fetal_growth/weight/0.73354187
131MP0005332_abnormal_amino_acid0.73319094
132MP0005377_hearing/vestibular/ear_phenot0.72988296
133MP0003878_abnormal_ear_physiology0.72988296
134MP0003936_abnormal_reproductive_system0.72804689
135MP0002693_abnormal_pancreas_physiology0.71235316
136MP0005647_abnormal_sex_gland0.69782689
137MP0002102_abnormal_ear_morphology0.69683267
138MP0005384_cellular_phenotype0.69264306
139MP0003221_abnormal_cardiomyocyte_apopto0.67166607
140MP0005187_abnormal_penis_morphology0.63015798
141MP0002396_abnormal_hematopoietic_system0.62320614
142MP0005408_hypopigmentation0.60152616
143MP0002269_muscular_atrophy0.59754519
144MP0005076_abnormal_cell_differentiation0.59388854
145MP0009697_abnormal_copulation0.58647189
146MP0000427_abnormal_hair_cycle0.58056319
147MP0001915_intracranial_hemorrhage0.55752889
148MP0003119_abnormal_digestive_system0.53845964
149MP0000613_abnormal_salivary_gland0.53582552
150MP0003755_abnormal_palate_morphology0.45596518
151MP0009703_decreased_birth_body0.45043366
152MP0000358_abnormal_cell_content/0.44827565
153MP0001293_anophthalmia0.44666807
154MP0000490_abnormal_crypts_of0.42776772
155MP0001727_abnormal_embryo_implantation0.40091803
156MP0003861_abnormal_nervous_system0.38251744
157MP0006036_abnormal_mitochondrial_physio0.37371141
158MP0004084_abnormal_cardiac_muscle0.36448128
159MP0000428_abnormal_craniofacial_morphol0.35105043
160MP0004264_abnormal_extraembryonic_tissu0.34930894
161MP0000383_abnormal_hair_follicle0.34681946
162MP0000432_abnormal_head_morphology0.34095985
163MP0004185_abnormal_adipocyte_glucose0.32818229
164MP0003950_abnormal_plasma_membrane0.32584178
165MP0002092_abnormal_eye_morphology0.31706113
166MP0002111_abnormal_tail_morphology0.31447651
167MP0003115_abnormal_respiratory_system0.31263158
168MP0000703_abnormal_thymus_morphology0.29928052
169MP0002009_preneoplasia0.29668082
170MP0006138_congestive_heart_failure0.29215645
171MP0000534_abnormal_ureter_morphology0.28330023
172MP0001529_abnormal_vocalization0.26810460
173MP0004036_abnormal_muscle_relaxation0.26543146

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)7.63530940
2Abnormal spermatogenesis (HP:0008669)7.20794728
3Chromsome breakage (HP:0040012)4.93990265
4Male infertility (HP:0003251)4.93034412
5Breast hypoplasia (HP:0003187)4.60801590
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.39102787
7Birth length less than 3rd percentile (HP:0003561)4.38967755
8Pancreatic cysts (HP:0001737)4.35324970
9Abnormality of the labia minora (HP:0012880)4.31428037
10Carpal bone hypoplasia (HP:0001498)4.19387152
11Pancreatic fibrosis (HP:0100732)3.97106441
12Premature ovarian failure (HP:0008209)3.89724426
13Facial hemangioma (HP:0000329)3.86445765
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.80235106
15Type II lissencephaly (HP:0007260)3.77346564
16Gonadotropin excess (HP:0000837)3.70880091
17Nephronophthisis (HP:0000090)3.70230652
18Abnormality of midbrain morphology (HP:0002418)3.60965406
19Molar tooth sign on MRI (HP:0002419)3.60965406
20Patellar aplasia (HP:0006443)3.57732117
21Papillary thyroid carcinoma (HP:0002895)3.57365916
22Impulsivity (HP:0100710)3.56305624
23True hermaphroditism (HP:0010459)3.51741430
24Infertility (HP:0000789)3.51244019
25Congenital stationary night blindness (HP:0007642)3.47046761
26Abnormality of the lower motor neuron (HP:0002366)3.46855758
27Abnormality of the renal cortex (HP:0011035)3.45907498
28Aplasia/Hypoplasia of the patella (HP:0006498)3.35363015
29Abnormality of the renal medulla (HP:0100957)3.31734353
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.27990372
31Abnormality of chromosome stability (HP:0003220)3.25259342
32Medial flaring of the eyebrow (HP:0010747)3.23024126
33Absent radius (HP:0003974)3.19763867
34Supernumerary spleens (HP:0009799)3.14872299
35Shawl scrotum (HP:0000049)3.10497103
36Oligodactyly (hands) (HP:0001180)3.08234044
37Aplasia involving forearm bones (HP:0009822)3.05722166
38Absent forearm bone (HP:0003953)3.05722166
39Secondary amenorrhea (HP:0000869)3.02057526
40Abnormality of the anterior horn cell (HP:0006802)3.01140078
41Degeneration of anterior horn cells (HP:0002398)3.01140078
42Abnormal drinking behavior (HP:0030082)2.98255911
43Polydipsia (HP:0001959)2.98255911
44Meckel diverticulum (HP:0002245)2.97052144
45Capillary hemangiomas (HP:0005306)2.93681510
46Tubular atrophy (HP:0000092)2.85023125
47Oligodactyly (HP:0012165)2.72104984
48Abnormality of the ileum (HP:0001549)2.71513425
49Abnormality of the preputium (HP:0100587)2.69076923
50Cystic liver disease (HP:0006706)2.67017412
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.65867136
52Attenuation of retinal blood vessels (HP:0007843)2.65752562
53Chronic hepatic failure (HP:0100626)2.62692377
54Cerebellar dysplasia (HP:0007033)2.62582937
55Ectopic kidney (HP:0000086)2.62360096
56Aplasia/Hypoplasia involving the musculature (HP:0001460)2.61601320
57Hyperventilation (HP:0002883)2.59520809
58Ankle contracture (HP:0006466)2.58892732
59Gait imbalance (HP:0002141)2.58819436
60Shoulder girdle muscle weakness (HP:0003547)2.58762012
61Bile duct proliferation (HP:0001408)2.57765784
62Abnormal biliary tract physiology (HP:0012439)2.57765784
63Small intestinal stenosis (HP:0012848)2.55654353
64Duodenal stenosis (HP:0100867)2.55654353
65Lissencephaly (HP:0001339)2.54027706
66Progressive inability to walk (HP:0002505)2.53359143
67Abolished electroretinogram (ERG) (HP:0000550)2.53321579
68Rhabdomyosarcoma (HP:0002859)2.52822682
69Sclerocornea (HP:0000647)2.48832156
70Congenital primary aphakia (HP:0007707)2.47953215
71Cerebral hypomyelination (HP:0006808)2.47558721
72Horseshoe kidney (HP:0000085)2.45509405
73Absent thumb (HP:0009777)2.44559000
74Abnormality of the pons (HP:0007361)2.41230501
75Inability to walk (HP:0002540)2.40380785
76Tubulointerstitial nephritis (HP:0001970)2.38595214
77Nephrogenic diabetes insipidus (HP:0009806)2.38557513
78Pendular nystagmus (HP:0012043)2.38312858
79Selective tooth agenesis (HP:0001592)2.36971082
80Colon cancer (HP:0003003)2.35997760
81Abnormal protein glycosylation (HP:0012346)2.34948057
82Abnormal glycosylation (HP:0012345)2.34948057
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34948057
84Abnormal protein N-linked glycosylation (HP:0012347)2.34948057
85Polyuria (HP:0000103)2.34025033
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33928094
87Abnormality of alanine metabolism (HP:0010916)2.33928094
88Hyperalaninemia (HP:0003348)2.33928094
89Renal cortical cysts (HP:0000803)2.33455670
90Hypoplasia of the pons (HP:0012110)2.32005428
91Amyotrophic lateral sclerosis (HP:0007354)2.31931052
92Abnormal rod and cone electroretinograms (HP:0008323)2.31441176
93Short thumb (HP:0009778)2.31068027
94Cortical dysplasia (HP:0002539)2.31045764
95Sandal gap (HP:0001852)2.30779876
96Atrophy/Degeneration involving motor neurons (HP:0007373)2.30718537
97Aplasia/Hypoplasia of the earlobes (HP:0009906)2.27954658
98Chronic bronchitis (HP:0004469)2.26992723
99Abnormal respiratory motile cilium physiology (HP:0012261)2.26083808
100Gaze-evoked nystagmus (HP:0000640)2.23679865
101Upper motor neuron abnormality (HP:0002127)2.23291901
102Wrist flexion contracture (HP:0001239)2.21816425
103Ureteral duplication (HP:0000073)2.21589559
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.21093168
105Absent/shortened dynein arms (HP:0200106)2.21093168
106Abnormal lung lobation (HP:0002101)2.18973055
107Breast aplasia (HP:0100783)2.18574728
108Aplasia/hypoplasia of the uterus (HP:0008684)2.18461170
109Abnormality of chromosome segregation (HP:0002916)2.17932188
110Spontaneous abortion (HP:0005268)2.17580013
111Sloping forehead (HP:0000340)2.17465022
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.16977770
113Aplasia/Hypoplasia of the breasts (HP:0010311)2.15912545
114Thyroid carcinoma (HP:0002890)2.12973690
115Congenital hepatic fibrosis (HP:0002612)2.11458043
116Medulloblastoma (HP:0002885)2.10422512
117Hypothermia (HP:0002045)2.10138159
118Keratoconus (HP:0000563)2.09708142
119Increased corneal curvature (HP:0100692)2.09708142
120Type I transferrin isoform profile (HP:0003642)2.07736077
121Methylmalonic acidemia (HP:0002912)2.07410783
122Abnormal respiratory motile cilium morphology (HP:0005938)2.06560881
123Abnormal respiratory epithelium morphology (HP:0012253)2.06560881
124Stomatitis (HP:0010280)2.05897999
125Duplicated collecting system (HP:0000081)2.05405394
126Spinal muscular atrophy (HP:0007269)2.00517607
127Genital tract atresia (HP:0001827)2.00281474
128Aplasia/Hypoplasia of the tibia (HP:0005772)2.00157527
129Clumsiness (HP:0002312)1.99134783
130Anencephaly (HP:0002323)1.98414080
131Pelvic girdle muscle weakness (HP:0003749)1.98279653
132Increased CSF lactate (HP:0002490)1.97982141
133Tubulointerstitial abnormality (HP:0001969)1.97811958
134Abnormal biliary tract morphology (HP:0012440)1.97648502
135Type 2 muscle fiber atrophy (HP:0003554)1.94397899
136Optic nerve hypoplasia (HP:0000609)1.93637948
137Pachygyria (HP:0001302)1.92674198
138Rough bone trabeculation (HP:0100670)1.92435226
13911 pairs of ribs (HP:0000878)1.92290052
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92211630
141Rhinitis (HP:0012384)1.91804536
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91268142
143Furrowed tongue (HP:0000221)1.89224895
144Abnormality of the duodenum (HP:0002246)1.88874633
145Cafe-au-lait spot (HP:0000957)1.88320091
146Bone marrow hypocellularity (HP:0005528)1.87055803
147Severe muscular hypotonia (HP:0006829)1.86137553
148Absent speech (HP:0001344)1.85839633
149Stomach cancer (HP:0012126)1.85793377
150Volvulus (HP:0002580)1.85661763
151Bony spicule pigmentary retinopathy (HP:0007737)1.85261533
152Hypoplasia of the uterus (HP:0000013)1.85186410
153CNS hypomyelination (HP:0003429)1.84276743
154Aplasia/Hypoplasia of the sternum (HP:0006714)1.84188859
155Poor coordination (HP:0002370)1.84109675
156Short tibia (HP:0005736)1.83232306
157Febrile seizures (HP:0002373)1.83116326
158Aplasia/Hypoplasia of the ulna (HP:0006495)1.83103063
159Abnormal urine output (HP:0012590)1.82980903
160Vaginal atresia (HP:0000148)1.82884525
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.82670677
162Mitochondrial inheritance (HP:0001427)1.82459728
163Abnormality of the carotid arteries (HP:0005344)1.82394884
164Protruding tongue (HP:0010808)1.80487411
165Decreased central vision (HP:0007663)1.80096395
166Increased nuchal translucency (HP:0010880)1.79928747
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77984148
168Progressive external ophthalmoplegia (HP:0000590)1.77980909
169Male pseudohermaphroditism (HP:0000037)1.77103961
170Fair hair (HP:0002286)1.76855753
171Astigmatism (HP:0000483)1.75935655
172Bicornuate uterus (HP:0000813)1.75398020
173Asplenia (HP:0001746)1.75284661
174Primary amenorrhea (HP:0000786)1.75062316
175Facial cleft (HP:0002006)1.74828207
176Retinal dysplasia (HP:0007973)1.74498933
177Postaxial foot polydactyly (HP:0001830)1.74168302
178Lipid accumulation in hepatocytes (HP:0006561)1.73650834
179Breast carcinoma (HP:0003002)1.73540833
180Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72478553
181Muscle fiber atrophy (HP:0100295)1.71918057
182Agitation (HP:0000713)1.70855658
183Acute necrotizing encephalopathy (HP:0006965)1.70518367
184Hepatic necrosis (HP:0002605)1.70464488
185Retinitis pigmentosa (HP:0000510)1.70209909
186Aplasia/Hypoplasia of the fibula (HP:0006492)1.70044936
187Hepatocellular necrosis (HP:0001404)1.69849635
188Ependymoma (HP:0002888)1.69412218
189Myelodysplasia (HP:0002863)1.69061790
190Stillbirth (HP:0003826)1.67954690
191Neoplasm of striated muscle (HP:0009728)1.67170989
192Biliary tract neoplasm (HP:0100574)1.66654058
193Hypergonadotropic hypogonadism (HP:0000815)1.65824128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.27702781
2FRK5.25182499
3CDC74.77623206
4WEE13.57944541
5PLK43.55358910
6TTK3.46591409
7BUB13.36286473
8MAP4K23.35905445
9NEK23.12804812
10ADRBK22.92844679
11PDK32.67293149
12PDK42.67293149
13WNK32.46732396
14STK38L2.46561427
15PLK12.41746855
16TXK2.32974628
17MAP3K62.32234161
18BRSK22.24107655
19GRK12.21470472
20NEK12.09815619
21CDK122.09723906
22EIF2AK12.00972809
23OXSR12.00900931
24MAPK131.97383103
25CHEK21.91818938
26CASK1.79846706
27WNK41.68846129
28MELK1.66124845
29PLK31.65415558
30STK31.62038221
31LATS21.59835243
32TLK11.53631605
33BRAF1.52802330
34PDK21.52169612
35BRSK11.45670892
36STK391.43885388
37MUSK1.43189794
38CDK81.41760924
39SRPK11.39779052
40CHEK11.39347061
41LATS11.38297546
42ATR1.37298431
43MST41.36316812
44DAPK21.35138467
45INSRR1.34807352
46AURKB1.28739655
47PRKD31.28011017
48STK241.25556764
49PNCK1.24125106
50VRK21.18912229
51CCNB11.17544645
52PTK2B1.17004183
53PBK1.15692208
54TRIM281.14974197
55DYRK31.13847658
56AURKA1.11593562
57ATM1.11184072
58TSSK61.10145480
59CDK191.07192023
60STK161.04543513
61CDK71.03672164
62IRAK31.03084130
63ERBB41.01502591
64STK100.99582673
65MKNK20.98207655
66MAP2K70.96135540
67MAP3K80.94683665
68ZAK0.93776692
69TNIK0.90854884
70ADRBK10.90248783
71TIE10.89367128
72NTRK30.88728148
73EPHA20.87975404
74PRKCE0.82711306
75MAP3K90.80433746
76EIF2AK30.79766581
77TEC0.79448729
78MAP2K20.79139920
79KSR20.78854405
80CDK40.78712779
81PHKG20.78458495
82PHKG10.78458495
83BCKDK0.77814158
84CDK20.77651892
85MAP3K40.77058994
86IKBKB0.73532255
87MOS0.73316728
88BMPR1B0.72779866
89CDK10.72685491
90CDK30.71716182
91PIK3CA0.69794743
92EEF2K0.69490620
93ARAF0.66754704
94EIF2AK20.64398885
95PRKCG0.63819129
96CSNK1G20.63036245
97PLK20.60260878
98ITK0.60031142
99CAMKK20.59085608
100MKNK10.58869812
101TNK20.57176582
102VRK10.55326684
103MAPKAPK50.55145030
104CHUK0.52887162
105STK110.52720514
106NUAK10.52243285
107RPS6KA50.51751271
108PRKCQ0.50990045
109RAF10.50778130
110PRKCI0.49817052
111TYRO30.48120489
112PAK30.48001322
113MAP2K60.47630871
114STK40.47497900
115FGFR20.47401787
116CSF1R0.46260042
117TAF10.46255285
118CSNK1G30.45528295
119GRK70.44886928
120IKBKE0.43878611
121CAMK10.43564462
122BMPR20.43297136
123MET0.42470366
124TESK10.42193362
125PAK10.41582794
126IRAK20.41114260
127DYRK20.41049392
128TAOK30.40946027
129IGF1R0.39626888
130CSNK2A10.39233747
131PIK3CG0.38336761
132CSNK1A10.37802035
133CAMK2A0.37155573
134TAOK10.36990248
135RPS6KB20.36541474
136CSNK1E0.36261218
137PINK10.36222638
138CSNK1G10.35674577
139CAMK1G0.35371268
140PRKCZ0.34628025
141TGFBR10.33837633
142RPS6KB10.33696072
143PASK0.33591335
144CDK90.33431398
145FES0.32790336
146NME10.32680925
147BRD40.32679207
148IRAK10.32432493
149CSNK2A20.31967144
150PRKDC0.31314423
151PRKG10.31250336
152STK380.31090996
153ABL20.30654355
154KSR10.30446446
155MAP3K20.29579248
156MAPK110.28801136
157CSNK1D0.27185262
158MTOR0.26909941
159GSK3B0.26535884
160PIM10.25838530
161PRKAA10.25748061
162BCR0.25503480
163MAPKAPK30.25413502
164MARK10.25011315

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.91192978
2Basal transcription factors_Homo sapiens_hsa030224.32467857
3Homologous recombination_Homo sapiens_hsa034403.98209930
4DNA replication_Homo sapiens_hsa030303.75939257
5RNA transport_Homo sapiens_hsa030133.64030134
6Cell cycle_Homo sapiens_hsa041103.61246042
7Mismatch repair_Homo sapiens_hsa034303.56649930
8RNA polymerase_Homo sapiens_hsa030203.47601111
9Proteasome_Homo sapiens_hsa030503.27195760
10Fanconi anemia pathway_Homo sapiens_hsa034602.98560355
11Caffeine metabolism_Homo sapiens_hsa002322.96762587
12Phototransduction_Homo sapiens_hsa047442.74695238
13Vitamin B6 metabolism_Homo sapiens_hsa007502.74044052
14Nucleotide excision repair_Homo sapiens_hsa034202.70304575
15Non-homologous end-joining_Homo sapiens_hsa034502.59678520
16Base excision repair_Homo sapiens_hsa034102.55391191
17RNA degradation_Homo sapiens_hsa030182.48192236
18Spliceosome_Homo sapiens_hsa030402.47325309
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45005372
20mRNA surveillance pathway_Homo sapiens_hsa030152.35686061
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32816558
22Oocyte meiosis_Homo sapiens_hsa041142.20452685
23Butanoate metabolism_Homo sapiens_hsa006502.10830669
24Nitrogen metabolism_Homo sapiens_hsa009102.04852128
25Pyrimidine metabolism_Homo sapiens_hsa002401.99266671
26Tryptophan metabolism_Homo sapiens_hsa003801.86655118
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85877784
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80918039
29Oxidative phosphorylation_Homo sapiens_hsa001901.73533003
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.71545644
31Nicotine addiction_Homo sapiens_hsa050331.70221907
32p53 signaling pathway_Homo sapiens_hsa041151.70162895
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.69360503
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63960177
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62684131
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51303063
37One carbon pool by folate_Homo sapiens_hsa006701.48093059
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47907211
39Purine metabolism_Homo sapiens_hsa002301.42283573
40Parkinsons disease_Homo sapiens_hsa050121.39882217
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34649381
42Olfactory transduction_Homo sapiens_hsa047401.32128385
43Peroxisome_Homo sapiens_hsa041461.25890718
44Selenocompound metabolism_Homo sapiens_hsa004501.16036999
45ABC transporters_Homo sapiens_hsa020101.14991741
46Epstein-Barr virus infection_Homo sapiens_hsa051691.12392840
47Dorso-ventral axis formation_Homo sapiens_hsa043201.11281397
48Regulation of autophagy_Homo sapiens_hsa041401.09665036
49Taste transduction_Homo sapiens_hsa047421.05675566
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.03591932
51beta-Alanine metabolism_Homo sapiens_hsa004101.00699094
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.00291091
53Linoleic acid metabolism_Homo sapiens_hsa005911.00090464
54Retinol metabolism_Homo sapiens_hsa008300.99921253
55Morphine addiction_Homo sapiens_hsa050320.95680732
56Pentose phosphate pathway_Homo sapiens_hsa000300.93051928
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.92693126
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91410953
59Chemical carcinogenesis_Homo sapiens_hsa052040.90642682
60Type I diabetes mellitus_Homo sapiens_hsa049400.86615637
61Sulfur metabolism_Homo sapiens_hsa009200.84778414
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83927029
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.82147296
64Circadian rhythm_Homo sapiens_hsa047100.81403424
65Primary immunodeficiency_Homo sapiens_hsa053400.81310253
66Herpes simplex infection_Homo sapiens_hsa051680.80593208
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.79623308
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78977927
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78255305
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73218256
71Fat digestion and absorption_Homo sapiens_hsa049750.71950452
72Ovarian steroidogenesis_Homo sapiens_hsa049130.70552524
73Serotonergic synapse_Homo sapiens_hsa047260.69370200
74Huntingtons disease_Homo sapiens_hsa050160.68423502
75Allograft rejection_Homo sapiens_hsa053300.66746193
76Fatty acid degradation_Homo sapiens_hsa000710.66482359
77HTLV-I infection_Homo sapiens_hsa051660.65743617
78Mineral absorption_Homo sapiens_hsa049780.64525900
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63501642
80Collecting duct acid secretion_Homo sapiens_hsa049660.63228199
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62382014
82Insulin secretion_Homo sapiens_hsa049110.62249483
83Thyroid cancer_Homo sapiens_hsa052160.62035471
84TGF-beta signaling pathway_Homo sapiens_hsa043500.61858847
85Asthma_Homo sapiens_hsa053100.61842179
86Ether lipid metabolism_Homo sapiens_hsa005650.61019117
87Folate biosynthesis_Homo sapiens_hsa007900.59383109
88Salivary secretion_Homo sapiens_hsa049700.58797791
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56373594
90Alzheimers disease_Homo sapiens_hsa050100.56019572
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55709720
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54655967
93Circadian entrainment_Homo sapiens_hsa047130.54409776
94Rheumatoid arthritis_Homo sapiens_hsa053230.54391755
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54159247
96Autoimmune thyroid disease_Homo sapiens_hsa053200.53210873
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53169339
98MicroRNAs in cancer_Homo sapiens_hsa052060.52718106
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.52237176
100Calcium signaling pathway_Homo sapiens_hsa040200.51261645
101Histidine metabolism_Homo sapiens_hsa003400.50730104
102Glutamatergic synapse_Homo sapiens_hsa047240.50236402
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50136064
104Viral carcinogenesis_Homo sapiens_hsa052030.48477894
105Glutathione metabolism_Homo sapiens_hsa004800.48443204
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47465212
107Glycerolipid metabolism_Homo sapiens_hsa005610.47373451
108Cardiac muscle contraction_Homo sapiens_hsa042600.46416754
109Graft-versus-host disease_Homo sapiens_hsa053320.45153159
110Hippo signaling pathway_Homo sapiens_hsa043900.42237997
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42074516
112Pancreatic cancer_Homo sapiens_hsa052120.40311519
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39716787
114Sulfur relay system_Homo sapiens_hsa041220.38186612
115Biosynthesis of amino acids_Homo sapiens_hsa012300.37297159
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36596658
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35800479
118Ribosome_Homo sapiens_hsa030100.34884737
119FoxO signaling pathway_Homo sapiens_hsa040680.34831041
120mTOR signaling pathway_Homo sapiens_hsa041500.33969228
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33245534
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32484648
123Arachidonic acid metabolism_Homo sapiens_hsa005900.30110515
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27826725
125Colorectal cancer_Homo sapiens_hsa052100.27571006
126Pyruvate metabolism_Homo sapiens_hsa006200.27449090
127Lysine degradation_Homo sapiens_hsa003100.25618608
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.25611946
129Influenza A_Homo sapiens_hsa051640.25564449
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24625463
131Adherens junction_Homo sapiens_hsa045200.23926508
132Antigen processing and presentation_Homo sapiens_hsa046120.23715993
133Small cell lung cancer_Homo sapiens_hsa052220.20183249
134Metabolic pathways_Homo sapiens_hsa011000.19555816
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18835471
136Tight junction_Homo sapiens_hsa045300.17602452
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13536777
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12738990
139Renal cell carcinoma_Homo sapiens_hsa052110.11896860
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.10187369
141Notch signaling pathway_Homo sapiens_hsa043300.09968616
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.09811780
143Hedgehog signaling pathway_Homo sapiens_hsa043400.06987723
144Vitamin digestion and absorption_Homo sapiens_hsa049770.06407656
145Carbon metabolism_Homo sapiens_hsa012000.06314344
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06065243
147Fructose and mannose metabolism_Homo sapiens_hsa000510.05802299
148Inositol phosphate metabolism_Homo sapiens_hsa005620.05364456
149Shigellosis_Homo sapiens_hsa051310.03254650
150Pathways in cancer_Homo sapiens_hsa052000.02866735
151Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.02227544
152Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.01526262
153Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01236815
154Prostate cancer_Homo sapiens_hsa052150.01054314
155Wnt signaling pathway_Homo sapiens_hsa04310-0.0313755
156Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0297409
157Protein export_Homo sapiens_hsa03060-0.0257055
158Sphingolipid metabolism_Homo sapiens_hsa00600-0.0252757
159Propanoate metabolism_Homo sapiens_hsa00640-0.0063203
160HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0034959
161Arginine and proline metabolism_Homo sapiens_hsa00330-0.0024684

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