ATAD2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)5.22672841
2establishment of protein localization to Golgi (GO:0072600)4.70059831
3nuclear pore complex assembly (GO:0051292)4.49370420
4mitotic sister chromatid cohesion (GO:0007064)4.49001420
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.36889285
6protein targeting to Golgi (GO:0000042)4.23455583
7retrograde transport, vesicle recycling within Golgi (GO:0000301)4.06570469
8interkinetic nuclear migration (GO:0022027)4.01048119
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.89069738
10nuclear pore organization (GO:0006999)3.86193661
11histone H3-K4 trimethylation (GO:0080182)3.81718638
12cytoplasmic mRNA processing body assembly (GO:0033962)3.75110857
13protein K11-linked deubiquitination (GO:0035871)3.73258525
14regulation of RNA export from nucleus (GO:0046831)3.61945988
15pore complex assembly (GO:0046931)3.60763209
16protein K48-linked deubiquitination (GO:0071108)3.58422337
17histone H3-K36 demethylation (GO:0070544)3.55639002
18regulation of establishment of cell polarity (GO:2000114)3.55572323
19regulation of DNA endoreduplication (GO:0032875)3.54342689
20peptidyl-lysine methylation (GO:0018022)3.52388375
21microtubule anchoring (GO:0034453)3.48267391
22histone H3-K9 methylation (GO:0051567)3.36937836
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35852502
24centriole replication (GO:0007099)3.33288026
25regulation of pigment cell differentiation (GO:0050932)3.29990638
26positive regulation of developmental pigmentation (GO:0048087)3.29050302
27kinetochore organization (GO:0051383)3.23632658
28regulation of B cell receptor signaling pathway (GO:0050855)3.22864940
29histone H3-K4 methylation (GO:0051568)3.21552987
30protein localization to Golgi apparatus (GO:0034067)3.21237606
31positive regulation of gamma-delta T cell activation (GO:0046645)3.19708606
32cerebellar Purkinje cell differentiation (GO:0021702)3.16618230
33meiotic chromosome segregation (GO:0045132)3.13842488
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.12060097
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.12060097
36regulation of translation, ncRNA-mediated (GO:0045974)3.12060097
37peptidyl-lysine trimethylation (GO:0018023)3.10259745
38positive regulation of granulocyte differentiation (GO:0030854)3.03878902
39cilium or flagellum-dependent cell motility (GO:0001539)3.02768310
40mitotic chromosome condensation (GO:0007076)3.02608425
41histone H2A monoubiquitination (GO:0035518)3.01816067
42histone H3-K9 modification (GO:0061647)2.97524033
43protein localization to kinetochore (GO:0034501)2.95580476
44regulation of establishment or maintenance of cell polarity (GO:0032878)2.94863147
45negative regulation of neurotransmitter secretion (GO:0046929)2.94346731
46microtubule nucleation (GO:0007020)2.93071991
47nucleus localization (GO:0051647)2.91106201
48centrosome localization (GO:0051642)2.90752914
49histone mRNA catabolic process (GO:0071044)2.89184189
50protein K63-linked deubiquitination (GO:0070536)2.89056458
51cellular response to ethanol (GO:0071361)2.88280246
52regulation of nucleobase-containing compound transport (GO:0032239)2.87275227
53forebrain neuron differentiation (GO:0021879)2.86284102
54kinetochore assembly (GO:0051382)2.84755621
55regulation of centriole replication (GO:0046599)2.83103092
56DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83049195
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.83022638
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.83022638
59positive regulation of mitotic sister chromatid separation (GO:1901970)2.83022638
60negative regulation of histone methylation (GO:0031061)2.82109704
61negative regulation of neurotransmitter transport (GO:0051589)2.81350744
62olfactory bulb development (GO:0021772)2.80476096
63single strand break repair (GO:0000012)2.77862201
64sister chromatid segregation (GO:0000819)2.77084547
65histone lysine demethylation (GO:0070076)2.76335419
66regulation of mitotic spindle organization (GO:0060236)2.75652857
67mitotic metaphase plate congression (GO:0007080)2.75510738
68resolution of meiotic recombination intermediates (GO:0000712)2.74941060
69regulation of spindle organization (GO:0090224)2.72552339
70sister chromatid cohesion (GO:0007062)2.71524945
71monoubiquitinated protein deubiquitination (GO:0035520)2.70065895
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.69691183
73histone-serine phosphorylation (GO:0035404)2.69653911
74rRNA catabolic process (GO:0016075)2.69486213
75snRNA transcription (GO:0009301)2.69405147
76activated T cell proliferation (GO:0050798)2.67171525
77definitive hemopoiesis (GO:0060216)2.66203533
78pre-miRNA processing (GO:0031054)2.64643765
79protein localization to chromosome, centromeric region (GO:0071459)2.64064737
80genitalia morphogenesis (GO:0035112)2.63598484
81reciprocal DNA recombination (GO:0035825)2.62210091
82reciprocal meiotic recombination (GO:0007131)2.62210091
83regulation of sister chromatid cohesion (GO:0007063)2.62204454
84positive regulation of DNA-templated transcription, initiation (GO:2000144)2.61172716
85protein localization to microtubule cytoskeleton (GO:0072698)2.60341467
86hepatocyte apoptotic process (GO:0097284)2.60238538
87histone lysine methylation (GO:0034968)2.60087535
88Golgi to endosome transport (GO:0006895)2.59181491
89histone demethylation (GO:0016577)2.58666282
90regulation of MHC class II biosynthetic process (GO:0045346)2.58650286
91spinal cord motor neuron differentiation (GO:0021522)2.58374204
92regulation of histone H3-K9 methylation (GO:0051570)2.55086988
93histone monoubiquitination (GO:0010390)2.55007495
94prenylation (GO:0097354)2.54714575
95protein prenylation (GO:0018342)2.54714575
96positive regulation of chromosome segregation (GO:0051984)2.53156680
97DNA damage response, signal transduction resulting in transcription (GO:0042772)2.50539233
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.50426095
99positive T cell selection (GO:0043368)2.49798885
100interferon-gamma production (GO:0032609)2.49126717
101DNA topological change (GO:0006265)2.48221824
102leukocyte aggregation (GO:0070486)2.47963627
103microglial cell activation (GO:0001774)2.47913021
104metaphase plate congression (GO:0051310)2.46495082
105regulation of sarcomere organization (GO:0060297)2.45815282
106negative regulation of B cell proliferation (GO:0030889)2.45701974
107nerve growth factor signaling pathway (GO:0038180)2.43695640
108neutrophil activation (GO:0042119)2.41752865
109B cell homeostasis (GO:0001782)2.41345367
110positive regulation of DNA-dependent DNA replication (GO:2000105)2.40531321
111ncRNA catabolic process (GO:0034661)2.40270327
112establishment of nucleus localization (GO:0040023)2.40246394
113positive regulation of histone H3-K4 methylation (GO:0051571)2.39783771
114mitotic sister chromatid segregation (GO:0000070)2.39563175
115neuronal stem cell maintenance (GO:0097150)2.38799693
116B cell receptor signaling pathway (GO:0050853)2.38785166
117pyrimidine nucleobase catabolic process (GO:0006208)2.38555358
118epithelial cilium movement (GO:0003351)2.37737090
119lipid translocation (GO:0034204)2.37395220
120phospholipid translocation (GO:0045332)2.37395220
121histone H3-K9 demethylation (GO:0033169)2.35301551
122positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.35127984
123mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.35127984
124regulation of centrosome duplication (GO:0010824)2.34800393
125chromatin assembly (GO:0031497)2.34750667
126regulation of telomere maintenance (GO:0032204)2.33840165
127mitotic nuclear envelope disassembly (GO:0007077)2.33497346
128positive regulation of histone methylation (GO:0031062)2.32420169
129negative regulation of granulocyte differentiation (GO:0030853)2.31927817
130detection of light stimulus involved in visual perception (GO:0050908)2.31868804
131detection of light stimulus involved in sensory perception (GO:0050962)2.31868804
132double-strand break repair via homologous recombination (GO:0000724)2.31701200
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.30816312
134modulation by symbiont of host immune response (GO:0052553)2.30816312
135positive regulation by symbiont of host defense response (GO:0052509)2.30816312
136modulation by symbiont of host defense response (GO:0052031)2.30816312
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.30816312
138modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.30816312
139regulation of gamma-delta T cell differentiation (GO:0045586)2.30228666
140negative regulation by host of viral transcription (GO:0043922)2.30156188
141attachment of spindle microtubules to kinetochore (GO:0008608)2.29427926
142regulation of gamma-delta T cell activation (GO:0046643)2.28889250
143positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28819297
144regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.27943060
145positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.27943060
146regulation of histone methylation (GO:0031060)2.27172100
147modulation by host of symbiont transcription (GO:0052472)2.26306446
148modulation by host of viral transcription (GO:0043921)2.26306446
149T cell migration (GO:0072678)2.25479961
150mRNA stabilization (GO:0048255)2.25308762
151RNA stabilization (GO:0043489)2.25308762
152regulation of interleukin-12 biosynthetic process (GO:0045075)2.25058015
153N-terminal protein amino acid acetylation (GO:0006474)2.23884867
154granulocyte activation (GO:0036230)2.23236822
155regulation of alpha-beta T cell proliferation (GO:0046640)2.22549567
156protein dealkylation (GO:0008214)2.22412442
157protein demethylation (GO:0006482)2.22412442
158regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.22193622
159positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.22193622
160positive regulation of mRNA 3-end processing (GO:0031442)2.22011225
161positive thymic T cell selection (GO:0045059)2.21171420
162NIK/NF-kappaB signaling (GO:0038061)2.20902804
163positive regulation of mRNA catabolic process (GO:0061014)2.20679987
164establishment of chromosome localization (GO:0051303)2.19886344
165NLS-bearing protein import into nucleus (GO:0006607)2.19760769
166histone H4-K12 acetylation (GO:0043983)2.19483678
167regulation of B cell differentiation (GO:0045577)2.19390091
168embryonic hemopoiesis (GO:0035162)2.19314176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.80955057
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.77924649
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.26950907
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.98807357
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.30068464
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.20699181
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15505271
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15066446
9* IRF8_21731497_ChIP-ChIP_J774_Mouse2.97943083
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.79632789
11TAF15_26573619_Chip-Seq_HEK293_Human2.65822909
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64031275
13IGF1R_20145208_ChIP-Seq_DFB_Human2.59612864
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58401582
15GBX2_23144817_ChIP-Seq_PC3_Human2.51575487
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42185731
17ZNF274_21170338_ChIP-Seq_K562_Hela2.39925462
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38966361
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38119181
20FUS_26573619_Chip-Seq_HEK293_Human2.28827516
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28315455
22* IRF8_27001747_Chip-Seq_BMDM_Mouse2.22686996
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21279990
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20559678
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20427540
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18477442
27EZH2_22144423_ChIP-Seq_EOC_Human2.11021876
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09226327
29* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03279493
30P300_19829295_ChIP-Seq_ESCs_Human2.02972494
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00956205
32ER_23166858_ChIP-Seq_MCF-7_Human1.95998003
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95995645
34VDR_22108803_ChIP-Seq_LS180_Human1.95138484
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86864210
36RUNX_20019798_ChIP-Seq_JUKART_Human1.82052004
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.78186385
38* STAT3_23295773_ChIP-Seq_U87_Human1.76706708
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75585930
40SCL_19346495_ChIP-Seq_HPC-7_Human1.75465347
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72673763
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71890147
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71453345
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70969057
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.70694244
46AR_21572438_ChIP-Seq_LNCaP_Human1.69717600
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.69108051
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.68663168
49* MYB_26560356_Chip-Seq_TH1_Human1.68623887
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68572101
51* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67658546
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65669460
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62225140
54CBP_20019798_ChIP-Seq_JUKART_Human1.62225140
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60111946
56MYC_22102868_ChIP-Seq_BL_Human1.59044419
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59035905
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.55613681
59IRF1_19129219_ChIP-ChIP_H3396_Human1.55370658
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53830717
61MYB_26560356_Chip-Seq_TH2_Human1.52834458
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50638671
63* TCF4_23295773_ChIP-Seq_U87_Human1.50421180
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.46570593
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44061713
66* FLI1_21867929_ChIP-Seq_TH2_Mouse1.37568927
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36593187
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35842443
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35695640
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32440749
71AR_25329375_ChIP-Seq_VCAP_Human1.32016444
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31950189
73BCAT_22108803_ChIP-Seq_LS180_Human1.30764454
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30363099
75* PU_27001747_Chip-Seq_BMDM_Mouse1.28986047
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28444501
77TP53_16413492_ChIP-PET_HCT116_Human1.25988272
78TCF7_22412390_ChIP-Seq_EML_Mouse1.24919504
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24702335
80* MAF_26560356_Chip-Seq_TH1_Human1.23382256
81* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23081509
82SPI1_23547873_ChIP-Seq_NB4_Human1.22982500
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.22496552
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.22072444
85* PRDM14_20953172_ChIP-Seq_ESCs_Human1.21951656
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21682797
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20793575
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.19145590
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.18129406
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17306104
91* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16622894
92VDR_21846776_ChIP-Seq_THP-1_Human1.16553230
93UTX_26944678_Chip-Seq_JUKART_Human1.15581754
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14581445
95AHR_22903824_ChIP-Seq_MCF-7_Human1.14224110
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13773627
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.09642441
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09614890
99P53_22387025_ChIP-Seq_ESCs_Mouse1.09218482
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09111207
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08820544
102TCF4_22108803_ChIP-Seq_LS180_Human1.08624746
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.08159551
104AR_21909140_ChIP-Seq_LNCAP_Human1.07823464
105RNF2_27304074_Chip-Seq_NSC_Mouse1.07283821
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07015677
107VDR_24787735_ChIP-Seq_THP-1_Human1.06044187
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.05650466
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.04309054
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03664226
111VDR_24763502_ChIP-Seq_THP-1_Human1.03227276
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03031871
113CDX2_22108803_ChIP-Seq_LS180_Human1.02830081
114* EWS_26573619_Chip-Seq_HEK293_Human1.01387958
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01382961
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.01233474
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.00220621
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99908952
119CRX_20693478_ChIP-Seq_RETINA_Mouse0.99001295
120* KDM2B_26808549_Chip-Seq_REH_Human0.98771056
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98721999
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98644451
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98464830
124SALL4_22934838_ChIP-ChIP_CD34+_Human0.98364851
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98145315
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.97307539
127GATA3_27048872_Chip-Seq_THYMUS_Human0.97146981
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96968389
129* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96884096
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95866587
131POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94988894
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90232630
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90009044
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89159344
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.88488822
136* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88043180
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87460234
138SPI1_23127762_ChIP-Seq_K562_Human0.83924015
139POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81632660
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.81460490
141KDM2B_26808549_Chip-Seq_DND41_Human0.81123699
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79661171
143BRD4_25478319_ChIP-Seq_HGPS_Human0.79211538
144TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78748943
145RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77995141
146* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77482686
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77104966
148PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76627688
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75732799
150OCT4_18555785_Chip-Seq_ESCs_Mouse0.75541506
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.74349599
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74349599
153TCF3_18692474_ChIP-Seq_MESCs_Mouse0.73792727
154HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73789916
155FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73122237
156SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72699351
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72444085
158GATA1_22025678_ChIP-Seq_K562_Human0.71804069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.01613479
2MP0008057_abnormal_DNA_replication3.29707239
3MP0001835_abnormal_antigen_presentation2.67485901
4MP0003111_abnormal_nucleus_morphology2.54769875
5MP0002396_abnormal_hematopoietic_system2.53059141
6MP0005076_abnormal_cell_differentiation2.50701776
7MP0010094_abnormal_chromosome_stability2.39556696
8MP0003077_abnormal_cell_cycle2.24462881
9MP0010307_abnormal_tumor_latency2.15825789
10MP0003693_abnormal_embryo_hatching2.07774545
11MP0001800_abnormal_humoral_immune2.05189459
12MP0002006_tumorigenesis2.01601339
13MP0003303_peritoneal_inflammation1.98900620
14MP0008995_early_reproductive_senescence1.95313168
15MP0005671_abnormal_response_to1.86569757
16MP0002452_abnormal_antigen_presenting1.81791853
17MP0003787_abnormal_imprinting1.80605096
18MP0010352_gastrointestinal_tract_polyps1.79521085
19MP0008058_abnormal_DNA_repair1.78789002
20MP0001790_abnormal_immune_system1.71992714
21MP0005387_immune_system_phenotype1.71992714
22MP0002398_abnormal_bone_marrow1.67686855
23MP0002166_altered_tumor_susceptibility1.66434262
24MP0004808_abnormal_hematopoietic_stem1.64426563
25MP0002723_abnormal_immune_serum1.62986618
26MP0008007_abnormal_cellular_replicative1.61554769
27MP0003436_decreased_susceptibility_to1.60720845
28MP0000427_abnormal_hair_cycle1.60329856
29MP0005000_abnormal_immune_tolerance1.59153141
30MP0001819_abnormal_immune_cell1.58687112
31MP0002420_abnormal_adaptive_immunity1.57349893
32MP0005397_hematopoietic_system_phenotyp1.55151259
33MP0001545_abnormal_hematopoietic_system1.55151259
34MP0003763_abnormal_thymus_physiology1.54395849
35MP0003195_calcinosis1.53966429
36MP0002419_abnormal_innate_immunity1.52409297
37MP0000685_abnormal_immune_system1.52148927
38MP0009278_abnormal_bone_marrow1.50205437
39MP0003646_muscle_fatigue1.48361886
40MP0005253_abnormal_eye_physiology1.44346681
41MP0006072_abnormal_retinal_apoptosis1.44110036
42MP0005025_abnormal_response_to1.43521599
43MP0000383_abnormal_hair_follicle1.41410650
44MP0009785_altered_susceptibility_to1.41100768
45MP0000716_abnormal_immune_system1.40453428
46MP0002009_preneoplasia1.40213868
47MP0003890_abnormal_embryonic-extraembry1.38119562
48MP0004147_increased_porphyrin_level1.35162752
49MP0003121_genomic_imprinting1.34151833
50MP0000703_abnormal_thymus_morphology1.33104234
51MP0000350_abnormal_cell_proliferation1.32554163
52MP0002405_respiratory_system_inflammati1.29540140
53MP0002148_abnormal_hypersensitivity_rea1.29070395
54MP0002722_abnormal_immune_system1.26796473
55MP0004957_abnormal_blastocyst_morpholog1.24760495
56MP0003724_increased_susceptibility_to1.24456502
57MP0009333_abnormal_splenocyte_physiolog1.24128058
58MP0005310_abnormal_salivary_gland1.22823730
59MP0003448_altered_tumor_morphology1.21680480
60MP0005174_abnormal_tail_pigmentation1.21377618
61MP0000778_abnormal_nervous_system1.21020368
62MP0010678_abnormal_skin_adnexa1.20999091
63MP0000733_abnormal_muscle_development1.19467040
64MP0003221_abnormal_cardiomyocyte_apopto1.18316809
65MP0000689_abnormal_spleen_morphology1.17691001
66MP0006082_CNS_inflammation1.16553891
67MP0005645_abnormal_hypothalamus_physiol1.16099451
68MP0008877_abnormal_DNA_methylation1.14796016
69MP0005551_abnormal_eye_electrophysiolog1.14509838
70MP0002429_abnormal_blood_cell1.13299669
71MP0005075_abnormal_melanosome_morpholog1.11517405
72MP0000631_abnormal_neuroendocrine_gland1.11398380
73MP0010155_abnormal_intestine_physiology1.11063995
74MP0001929_abnormal_gametogenesis1.09857045
75MP0001672_abnormal_embryogenesis/_devel1.09851298
76MP0005380_embryogenesis_phenotype1.09851298
77MP0006276_abnormal_autonomic_nervous1.09814715
78MP0003698_abnormal_male_reproductive1.05891280
79MP0004142_abnormal_muscle_tone1.05806182
80MP0003937_abnormal_limbs/digits/tail_de1.05648650
81MP0008961_abnormal_basal_metabolism1.05437144
82MP0004947_skin_inflammation1.05043938
83MP0002086_abnormal_extraembryonic_tissu1.04750031
84MP0005257_abnormal_intraocular_pressure1.03986917
85MP0000490_abnormal_crypts_of1.03567874
86MP0006292_abnormal_olfactory_placode1.03449960
87MP0004145_abnormal_muscle_electrophysio0.99275507
88MP0002019_abnormal_tumor_incidence0.99258996
89MP0003984_embryonic_growth_retardation0.99109916
90MP0002088_abnormal_embryonic_growth/wei0.99087516
91MP0003656_abnormal_erythrocyte_physiolo0.98989370
92MP0000465_gastrointestinal_hemorrhage0.96301477
93MP0002102_abnormal_ear_morphology0.92058114
94MP0000372_irregular_coat_pigmentation0.91664117
95MP0003122_maternal_imprinting0.91619198
96MP0001984_abnormal_olfaction0.91201188
97MP0002084_abnormal_developmental_patter0.90812928
98MP0004924_abnormal_behavior0.90741495
99MP0005386_behavior/neurological_phenoty0.90741495
100MP0001853_heart_inflammation0.90685441
101MP0000566_synostosis0.90291245
102MP0002638_abnormal_pupillary_reflex0.89992958
103MP0002751_abnormal_autonomic_nervous0.89042091
104MP0004197_abnormal_fetal_growth/weight/0.88961218
105MP0001730_embryonic_growth_arrest0.88621076
106MP0000432_abnormal_head_morphology0.88345727
107MP0003950_abnormal_plasma_membrane0.88300464
108MP0003941_abnormal_skin_development0.88175869
109MP0003252_abnormal_bile_duct0.88016085
110MP0005248_abnormal_Harderian_gland0.87723584
111MP0003943_abnormal_hepatobiliary_system0.87302941
112MP0004381_abnormal_hair_follicle0.87277716
113MP0000015_abnormal_ear_pigmentation0.86660045
114MP0002098_abnormal_vibrissa_morphology0.86465450
115MP0001188_hyperpigmentation0.86213769
116MP0001845_abnormal_inflammatory_respons0.85755578
117MP0001293_anophthalmia0.85485827
118MP0002085_abnormal_embryonic_tissue0.85023510
119MP0003453_abnormal_keratinocyte_physiol0.84591987
120MP0000647_abnormal_sebaceous_gland0.83569745
121MP0005266_abnormal_metabolism0.83424101
122MP0003567_abnormal_fetal_cardiomyocyte0.81617224
123MP0009703_decreased_birth_body0.80901186
124MP0004185_abnormal_adipocyte_glucose0.80277054
125MP0003091_abnormal_cell_migration0.79791534
126MP0001286_abnormal_eye_development0.79599785
127MP0000858_altered_metastatic_potential0.79227472
128MP0002928_abnormal_bile_duct0.79078243
129MP0000371_diluted_coat_color0.78806972
130MP0009046_muscle_twitch0.78607355
131MP0009115_abnormal_fat_cell0.78411534
132MP0002095_abnormal_skin_pigmentation0.78073937
133MP0000313_abnormal_cell_death0.77807226
134MP0003566_abnormal_cell_adhesion0.77532617
135MP0004510_myositis0.77457700
136MP0000627_abnormal_mammary_gland0.77274600
137MP0001986_abnormal_taste_sensitivity0.77218694
138MP0003828_pulmonary_edema0.76967664
139MP0005410_abnormal_fertilization0.76041537
140MP0005391_vision/eye_phenotype0.75292642
141MP0000955_abnormal_spinal_cord0.74577896
142MP0002210_abnormal_sex_determination0.73939586
143MP0001851_eye_inflammation0.73791392
144MP0001324_abnormal_eye_pigmentation0.73474222
145MP0005647_abnormal_sex_gland0.73050313
146MP0004133_heterotaxia0.71864781
147MP0003880_abnormal_central_pattern0.71307822
148MP0002067_abnormal_sensory_capabilities0.70624184
149MP0004742_abnormal_vestibular_system0.69659492
150MP0000653_abnormal_sex_gland0.69607057
151MP0004484_altered_response_of0.68856958
152MP0001485_abnormal_pinna_reflex0.64599445
153MP0009697_abnormal_copulation0.64036119
154MP0001145_abnormal_male_reproductive0.63966723

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.49782688
2Volvulus (HP:0002580)3.78826048
3Chromsome breakage (HP:0040012)3.71293403
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60711323
5Chronic hepatic failure (HP:0100626)3.58693727
6Prostate neoplasm (HP:0100787)3.27760640
7Pancreatic cysts (HP:0001737)3.24665305
8Ectopic kidney (HP:0000086)3.06097774
9Pancreatic fibrosis (HP:0100732)2.98039729
10Recurrent bacterial skin infections (HP:0005406)2.94882145
11Hyperventilation (HP:0002883)2.94711674
12Genetic anticipation (HP:0003743)2.92783936
13Recurrent abscess formation (HP:0002722)2.89503616
14Lip pit (HP:0100267)2.85809522
15Eczematoid dermatitis (HP:0000976)2.81927293
16Truncal obesity (HP:0001956)2.81612343
17Recurrent viral infections (HP:0004429)2.77744478
18Abnormality of the nasal septum (HP:0000419)2.68428911
19Abnormality of the renal cortex (HP:0011035)2.68373030
20Abnormality of the renal medulla (HP:0100957)2.67093862
21Acute myeloid leukemia (HP:0004808)2.62484664
22Nephronophthisis (HP:0000090)2.61835943
23Short 4th metacarpal (HP:0010044)2.59896582
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59896582
25True hermaphroditism (HP:0010459)2.54836887
26Long eyelashes (HP:0000527)2.54704424
27Progressive cerebellar ataxia (HP:0002073)2.53144639
28Protruding tongue (HP:0010808)2.51304882
29Fair hair (HP:0002286)2.51112361
30Recurrent fungal infections (HP:0002841)2.50091788
31Abnormality of DNA repair (HP:0003254)2.47932488
32Drooling (HP:0002307)2.47582173
33Thyroiditis (HP:0100646)2.43418763
34Acute lymphatic leukemia (HP:0006721)2.43310647
35Molar tooth sign on MRI (HP:0002419)2.42631736
36Abnormality of midbrain morphology (HP:0002418)2.42631736
37Thyroid carcinoma (HP:0002890)2.41782849
38Abnormality of chromosome stability (HP:0003220)2.39734190
39Medial flaring of the eyebrow (HP:0010747)2.39699802
40Absent frontal sinuses (HP:0002688)2.36846088
41Tubulointerstitial nephritis (HP:0001970)2.35328539
42Excessive salivation (HP:0003781)2.34071140
43Poor coordination (HP:0002370)2.34060700
44Mediastinal lymphadenopathy (HP:0100721)2.32004377
45Gaze-evoked nystagmus (HP:0000640)2.29201025
46Widely spaced teeth (HP:0000687)2.27714188
47Stomach cancer (HP:0012126)2.27649255
48Intestinal atresia (HP:0011100)2.23686628
49Urethral obstruction (HP:0000796)2.21334803
50Hypochromic microcytic anemia (HP:0004840)2.20673807
51Congenital primary aphakia (HP:0007707)2.17385940
52Hypoplastic labia majora (HP:0000059)2.16882457
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16755915
54Recurrent gram-negative bacterial infections (HP:0005420)2.16065589
55T lymphocytopenia (HP:0005403)2.16032985
56Midline defect of the nose (HP:0004122)2.13014879
57Oligodactyly (hands) (HP:0001180)2.12908402
58Gait imbalance (HP:0002141)2.11121930
59Pigmentary retinal degeneration (HP:0001146)2.08600933
60Abnormality of the prostate (HP:0008775)2.07696325
61Agammaglobulinemia (HP:0004432)2.07089003
62Abnormality of T cell number (HP:0011839)2.06162373
63Abnormality of the labia majora (HP:0012881)2.03633300
64Genital tract atresia (HP:0001827)2.02730728
65Clubbing of toes (HP:0100760)2.02704408
66Duplicated collecting system (HP:0000081)2.02003629
67Deep philtrum (HP:0002002)2.01295963
68Hypoplastic iliac wings (HP:0002866)2.00823591
69Cellulitis (HP:0100658)2.00578373
70Subacute progressive viral hepatitis (HP:0006572)2.00427479
71Aplasia/Hypoplasia of the uvula (HP:0010293)1.99988410
72Anal stenosis (HP:0002025)1.99437640
73Nephrogenic diabetes insipidus (HP:0009806)1.99102826
74Febrile seizures (HP:0002373)1.98985707
75Severe combined immunodeficiency (HP:0004430)1.98379370
76Sparse lateral eyebrow (HP:0005338)1.98257527
77Abnormality of the preputium (HP:0100587)1.95324807
78Cupped ear (HP:0000378)1.95141489
79Vaginal atresia (HP:0000148)1.94088582
80Abnormality of the intervertebral disk (HP:0005108)1.93685248
81Stomatitis (HP:0010280)1.92794507
82Prominent nose (HP:0000448)1.91988676
83Autoimmune thrombocytopenia (HP:0001973)1.91645612
84Abnormal biliary tract physiology (HP:0012439)1.91320174
85Bile duct proliferation (HP:0001408)1.91320174
86Curly hair (HP:0002212)1.91057587
87Rhabdomyosarcoma (HP:0002859)1.89728983
88Syringomyelia (HP:0003396)1.89512300
89Spinal cord lesions (HP:0100561)1.89512300
90Congenital stationary night blindness (HP:0007642)1.88978494
91Renal cortical cysts (HP:0000803)1.88972271
92Generalized hypopigmentation of hair (HP:0011358)1.88159935
93Cystic liver disease (HP:0006706)1.87847062
94Impulsivity (HP:0100710)1.87369137
95Lymphopenia (HP:0001888)1.87044080
96Abnormality of the ischium (HP:0003174)1.85737518
97Gingivitis (HP:0000230)1.85658983
98IgM deficiency (HP:0002850)1.85590232
99Recurrent skin infections (HP:0001581)1.85569741
100Narrow palate (HP:0000189)1.85200805
101Obstructive lung disease (HP:0006536)1.84411701
102Chronic obstructive pulmonary disease (HP:0006510)1.84411701
103Viral hepatitis (HP:0006562)1.84149362
104Tubular atrophy (HP:0000092)1.83282853
105Supernumerary ribs (HP:0005815)1.82810018
106Periodontitis (HP:0000704)1.82325060
107Combined immunodeficiency (HP:0005387)1.82291749
108Recurrent cutaneous fungal infections (HP:0011370)1.81152647
109Chronic mucocutaneous candidiasis (HP:0002728)1.81152647
110Growth hormone deficiency (HP:0000824)1.80340753
111Attenuation of retinal blood vessels (HP:0007843)1.80209914
112Cystic hygroma (HP:0000476)1.79326397
113Depressed nasal tip (HP:0000437)1.78824636
114Hypoplastic ischia (HP:0003175)1.78432676
115Abnormality of the renal collecting system (HP:0004742)1.78276550
116Meckel diverticulum (HP:0002245)1.77414924
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.77209386
118Heterotopia (HP:0002282)1.77175928
119Recurrent pneumonia (HP:0006532)1.77170760
120Submucous cleft hard palate (HP:0000176)1.76578787
121Papillary thyroid carcinoma (HP:0002895)1.76522816
122Hepatoblastoma (HP:0002884)1.76370153
123Panhypogammaglobulinemia (HP:0003139)1.74543120
124Hip dysplasia (HP:0001385)1.74221911
125Limited elbow extension (HP:0001377)1.74086546
126Sandal gap (HP:0001852)1.73777027
127Highly arched eyebrow (HP:0002553)1.72821849
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72486240
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.72486240
130Myelodysplasia (HP:0002863)1.72269242
131Lissencephaly (HP:0001339)1.71722740
132Leiomyosarcoma (HP:0100243)1.71636365
133Uterine leiomyosarcoma (HP:0002891)1.71636365
134Congenital hepatic fibrosis (HP:0002612)1.71290007
135Chronic diarrhea (HP:0002028)1.71244008
136Entropion (HP:0000621)1.70946951
137Cutis marmorata (HP:0000965)1.69980920
138Abnormality of the ileum (HP:0001549)1.69050720
139Absent speech (HP:0001344)1.69035824
140Abnormal pancreas size (HP:0012094)1.68336859
141Increased number of teeth (HP:0011069)1.67805445
142Supernumerary bones of the axial skeleton (HP:0009144)1.67328221
143Transitional cell carcinoma of the bladder (HP:0006740)1.67171806
144Neoplasm of the tracheobronchial system (HP:0100552)1.67103078
145Retrobulbar optic neuritis (HP:0100654)1.66744090
146Optic neuritis (HP:0100653)1.66744090
147Sloping forehead (HP:0000340)1.66325533
148Nephroblastoma (Wilms tumor) (HP:0002667)1.65864415
149Vasculitis (HP:0002633)1.65742420
150Cortical dysplasia (HP:0002539)1.65564605
151Patellar aplasia (HP:0006443)1.65035412
152Abnormality of salivation (HP:0100755)1.64824271
153Broad-based gait (HP:0002136)1.64585998
154Meningitis (HP:0001287)1.64487178
155Abnormality of eosinophils (HP:0001879)1.63562586
156Leukocytosis (HP:0001974)1.62856174
157Abnormality of the parietal bone (HP:0002696)1.62850330
158Tapered finger (HP:0001182)1.62537500
159Shawl scrotum (HP:0000049)1.62223236
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.62132847
161Microtia (HP:0008551)1.61889580
162Abnormality of the columella (HP:0009929)1.61678743
163Neoplasm of the adrenal cortex (HP:0100641)1.61471824
164Birth length less than 3rd percentile (HP:0003561)1.61405271
165Medulloblastoma (HP:0002885)1.61003016
166Facial hemangioma (HP:0000329)1.60907864
167Poikilocytosis (HP:0004447)1.60706960
168Tubulointerstitial abnormality (HP:0001969)1.60570861
169Acanthocytosis (HP:0001927)1.60527764
170Eosinophilia (HP:0001880)1.60309633
171Low anterior hairline (HP:0000294)1.60228124
172Poikiloderma (HP:0001029)1.60123778
173Aqueductal stenosis (HP:0002410)1.59363995
174Dynein arm defect of respiratory motile cilia (HP:0012255)1.58519403
175Absent/shortened dynein arms (HP:0200106)1.58519403
176Hyperkalemia (HP:0002153)1.57850678
177Postaxial foot polydactyly (HP:0001830)1.57699600
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.57467694
179Exotropia (HP:0000577)1.57357966
180Alveolar cell carcinoma (HP:0006519)1.57016397
181Thick eyebrow (HP:0000574)1.56442595
182Aplasia/Hypoplasia of the sternum (HP:0006714)1.55788304
183Embryonal renal neoplasm (HP:0011794)1.55365098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.36754498
2FRK4.24030988
3MAP3K143.02683905
4LATS12.88533325
5NEK22.61309886
6CDC72.58985047
7MAP3K42.33653644
8AKT32.33095959
9ACVR1B2.30498130
10STK32.17934747
11BRD42.17664576
12MAP3K101.99695872
13PIK3CG1.96068084
14IRAK41.95867221
15STK41.90535748
16STK101.84304643
17NUAK11.82285693
18MAP4K11.81749631
19MAP4K21.81026730
20CASK1.79612880
21PNCK1.78757529
22JAK31.76859472
23BMPR1B1.72911659
24MKNK21.71635107
25CAMK1D1.66287922
26CHUK1.62385482
27WNK31.60645427
28TXK1.59915912
29IRAK31.58913074
30TYK21.57682740
31PIM11.56933849
32MARK31.56614019
33TNIK1.46861767
34MARK11.46051573
35TAOK31.37063100
36PIK3CA1.35291932
37MAPK131.33788959
38MKNK11.33397233
39CDK61.31971984
40BLK1.30960264
41SRPK11.30390609
42PLK41.29931158
43CSK1.28764211
44CAMK1G1.28521644
45JAK11.28398007
46MAP3K91.27982752
47RPS6KA41.25323871
48FGFR31.22945621
49BCR1.22347025
50ATR1.21829266
51CDK41.21527634
52MELK1.21486113
53SIK21.20237473
54CDK31.19319421
55IKBKB1.19307435
56IKBKE1.19183685
57EPHA31.17160033
58ADRBK21.17107794
59CHEK11.14036752
60ZAK1.09847417
61SGK2231.08184115
62SGK4941.08184115
63STK38L1.07692445
64WNK11.06852118
65EIF2AK21.06531023
66ATM1.06469044
67CHEK21.04322092
68KIT1.04128813
69BMPR21.03570187
70RIPK41.03281876
71TAF10.99456678
72MAP2K70.94234012
73MAP3K20.92341854
74ERBB30.90835687
75CDK70.90285311
76FGR0.89818082
77INSRR0.86678943
78TEC0.85710954
79CSF1R0.85542514
80TLK10.84778308
81PDGFRB0.84191575
82MAP2K40.83101042
83AURKB0.82998062
84MTOR0.82795599
85DMPK0.82129644
86ITK0.81669785
87IRAK10.78978257
88KSR10.78758189
89STK390.78625973
90FGFR20.77207548
91DYRK30.76859808
92TTK0.76791204
93EIF2AK30.76382733
94CLK10.75119278
95SGK30.73642834
96PINK10.73426589
97PAK30.73396709
98YES10.72667009
99CDK20.70167570
100CDK90.69524870
101LCK0.69035090
102HCK0.68870590
103RAF10.68306253
104TRIM280.67879634
105PLK30.67824368
106PLK10.67351004
107LYN0.67132973
108MAPK150.66417057
109MAP3K130.66274233
110RPS6KA50.65490625
111ERBB40.64506192
112TYRO30.64320673
113OXSR10.63469841
114TRPM70.63425384
115MATK0.63132948
116CAMKK20.63092987
117PBK0.62789699
118PTK60.62578519
119DYRK1A0.61128305
120MAP3K60.60441758
121OBSCN0.59149868
122CDK10.58514559
123MAPK140.58418706
124GRK10.58262767
125NLK0.58080603
126GRK60.57656649
127NEK90.57161888
128NTRK20.56956738
129CAMK40.56849982
130BTK0.56571672
131VRK10.56457126
132PLK20.55928102
133TGFBR20.54763624
134SYK0.54432879
135TGFBR10.54371925
136SGK10.53442948
137ERBB20.52846333
138DYRK1B0.52564889
139CSNK1D0.52283657
140BRSK20.51792046
141JAK20.50428869
142PRKCQ0.50117162
143NEK10.49751266
144SGK20.49542105
145MAP3K70.49177987
146MAP3K80.49163399
147WNK40.48865850
148AKT10.48481610
149TSSK60.48228041
150MAPK100.46401111
151TBK10.46222286
152ABL10.46160204
153PKN10.46018934
154STK240.45155023
155ALK0.44754434
156AKT20.42843306
157GSK3B0.41694601

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.44823733
2Primary immunodeficiency_Homo sapiens_hsa053401.99122913
3Herpes simplex infection_Homo sapiens_hsa051681.84438869
4Leishmaniasis_Homo sapiens_hsa051401.83097954
5Measles_Homo sapiens_hsa051621.82839368
6Fanconi anemia pathway_Homo sapiens_hsa034601.76894660
7Non-homologous end-joining_Homo sapiens_hsa034501.72891597
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72591430
9Cell cycle_Homo sapiens_hsa041101.66544546
10Osteoclast differentiation_Homo sapiens_hsa043801.64468554
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.63980421
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59682129
13B cell receptor signaling pathway_Homo sapiens_hsa046621.55721794
14Lysine degradation_Homo sapiens_hsa003101.54821982
15MicroRNAs in cancer_Homo sapiens_hsa052061.52554402
16Hematopoietic cell lineage_Homo sapiens_hsa046401.51392996
17Graft-versus-host disease_Homo sapiens_hsa053321.51322837
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.48719304
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48167830
20Taste transduction_Homo sapiens_hsa047421.45161232
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42109872
22Systemic lupus erythematosus_Homo sapiens_hsa053221.38044158
23p53 signaling pathway_Homo sapiens_hsa041151.37158719
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.36339804
25Phototransduction_Homo sapiens_hsa047441.35352336
26Influenza A_Homo sapiens_hsa051641.34612078
27Alcoholism_Homo sapiens_hsa050341.32703881
28TNF signaling pathway_Homo sapiens_hsa046681.30771567
29Chronic myeloid leukemia_Homo sapiens_hsa052201.29473115
30T cell receptor signaling pathway_Homo sapiens_hsa046601.28200360
31Allograft rejection_Homo sapiens_hsa053301.27171543
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26900338
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23818839
34Toxoplasmosis_Homo sapiens_hsa051451.23393637
35Hepatitis B_Homo sapiens_hsa051611.23304326
36Ether lipid metabolism_Homo sapiens_hsa005651.22216941
37Small cell lung cancer_Homo sapiens_hsa052221.20502580
38Viral carcinogenesis_Homo sapiens_hsa052031.18421539
39Linoleic acid metabolism_Homo sapiens_hsa005911.17428997
40Nicotine addiction_Homo sapiens_hsa050331.17178827
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14994637
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14932610
43Pancreatic cancer_Homo sapiens_hsa052121.14883089
44Viral myocarditis_Homo sapiens_hsa054161.14715011
45mRNA surveillance pathway_Homo sapiens_hsa030151.14443276
46Basal transcription factors_Homo sapiens_hsa030221.10855729
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09894568
48Acute myeloid leukemia_Homo sapiens_hsa052211.09818333
49ABC transporters_Homo sapiens_hsa020101.09694404
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.09346019
51Apoptosis_Homo sapiens_hsa042101.07525011
52Chemokine signaling pathway_Homo sapiens_hsa040621.07174340
53Inositol phosphate metabolism_Homo sapiens_hsa005621.07105000
54Malaria_Homo sapiens_hsa051441.07052875
55Adherens junction_Homo sapiens_hsa045201.06351595
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05572396
57Long-term depression_Homo sapiens_hsa047301.05440662
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05183549
59Tuberculosis_Homo sapiens_hsa051521.05128276
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04828645
61Antigen processing and presentation_Homo sapiens_hsa046121.04424371
62Homologous recombination_Homo sapiens_hsa034401.02929710
63Nitrogen metabolism_Homo sapiens_hsa009101.02098728
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01376578
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00419029
66HTLV-I infection_Homo sapiens_hsa051661.00161101
67Prostate cancer_Homo sapiens_hsa052150.99124959
68RNA transport_Homo sapiens_hsa030130.98581740
69TGF-beta signaling pathway_Homo sapiens_hsa043500.97193024
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97078049
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96449466
72Olfactory transduction_Homo sapiens_hsa047400.94539880
73Colorectal cancer_Homo sapiens_hsa052100.93529460
74Notch signaling pathway_Homo sapiens_hsa043300.92967649
75Legionellosis_Homo sapiens_hsa051340.92799742
76Staphylococcus aureus infection_Homo sapiens_hsa051500.92267680
77FoxO signaling pathway_Homo sapiens_hsa040680.92256555
78RNA degradation_Homo sapiens_hsa030180.91474332
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91256401
80Base excision repair_Homo sapiens_hsa034100.90603849
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90582861
82Asthma_Homo sapiens_hsa053100.89655680
83Selenocompound metabolism_Homo sapiens_hsa004500.89506324
84Epstein-Barr virus infection_Homo sapiens_hsa051690.84368468
85Serotonergic synapse_Homo sapiens_hsa047260.83845851
86ErbB signaling pathway_Homo sapiens_hsa040120.82990081
87Autoimmune thyroid disease_Homo sapiens_hsa053200.78913163
88Hepatitis C_Homo sapiens_hsa051600.78898020
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78672146
90Pertussis_Homo sapiens_hsa051330.78384947
91Regulation of autophagy_Homo sapiens_hsa041400.77617192
92Spliceosome_Homo sapiens_hsa030400.77462624
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.76876068
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75892888
95Basal cell carcinoma_Homo sapiens_hsa052170.75824320
96Morphine addiction_Homo sapiens_hsa050320.74016592
97Prolactin signaling pathway_Homo sapiens_hsa049170.73970497
98mTOR signaling pathway_Homo sapiens_hsa041500.72924896
99Endometrial cancer_Homo sapiens_hsa052130.72371197
100Cholinergic synapse_Homo sapiens_hsa047250.72308914
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71013193
102Pathways in cancer_Homo sapiens_hsa052000.70828954
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70341502
104Mismatch repair_Homo sapiens_hsa034300.70012044
105Platelet activation_Homo sapiens_hsa046110.69056178
106Fatty acid biosynthesis_Homo sapiens_hsa000610.68903722
107Non-small cell lung cancer_Homo sapiens_hsa052230.66943757
108Proteoglycans in cancer_Homo sapiens_hsa052050.66464439
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65650306
110DNA replication_Homo sapiens_hsa030300.65127853
111Dorso-ventral axis formation_Homo sapiens_hsa043200.64239791
112Type I diabetes mellitus_Homo sapiens_hsa049400.64200523
113Wnt signaling pathway_Homo sapiens_hsa043100.62728538
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62461068
115Glutamatergic synapse_Homo sapiens_hsa047240.62139971
116African trypanosomiasis_Homo sapiens_hsa051430.61788046
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.59046944
118Nucleotide excision repair_Homo sapiens_hsa034200.58636213
119Butanoate metabolism_Homo sapiens_hsa006500.58634673
120Type II diabetes mellitus_Homo sapiens_hsa049300.58025598
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57835551
122Hippo signaling pathway_Homo sapiens_hsa043900.57767256
123Renal cell carcinoma_Homo sapiens_hsa052110.56077036
124Shigellosis_Homo sapiens_hsa051310.56020364
125Salmonella infection_Homo sapiens_hsa051320.55788715
126Estrogen signaling pathway_Homo sapiens_hsa049150.55234876
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54301081
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.53880403
129Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53177919
130Oxytocin signaling pathway_Homo sapiens_hsa049210.52906497
131cAMP signaling pathway_Homo sapiens_hsa040240.52365172
132Circadian rhythm_Homo sapiens_hsa047100.51730590
133MAPK signaling pathway_Homo sapiens_hsa040100.51625628
134Insulin resistance_Homo sapiens_hsa049310.47872482
135Choline metabolism in cancer_Homo sapiens_hsa052310.47741249

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »