ATAD3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitously expressed mitochondrial membrane protein that contributes to mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. This gene is a member of the ATPase family AAA-domain containing 3 gene family which, in humans, includes two other paralogs. Naturally occurring mutations in this gene are associated with distinct neurological syndromes including Harel-Yoon syndrome. High-level expression of this gene is associated with poor survival in breast cancer patients. A homozygous knockout of the orthologous gene in mice results in embryonic lethality at day 7.5 due to growth retardation and defective development of the trophoblast lineage. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)5.08612984
2mitotic chromosome condensation (GO:0007076)4.70126700
3ribosomal small subunit assembly (GO:0000028)4.61470484
4folic acid metabolic process (GO:0046655)4.51386438
5nucleobase biosynthetic process (GO:0046112)4.49515957
6DNA unwinding involved in DNA replication (GO:0006268)4.48977907
7glycine metabolic process (GO:0006544)4.37179143
8maturation of SSU-rRNA (GO:0030490)4.26988652
9COPI coating of Golgi vesicle (GO:0048205)4.25832821
10Golgi transport vesicle coating (GO:0048200)4.25832821
11formation of translation preinitiation complex (GO:0001731)4.16292872
12IMP biosynthetic process (GO:0006188)4.11678552
13DNA deamination (GO:0045006)4.05510083
14DNA strand elongation involved in DNA replication (GO:0006271)4.02575238
15purine nucleobase biosynthetic process (GO:0009113)3.97095321
16regulation of mammary gland epithelial cell proliferation (GO:0033599)3.95919130
17viral transcription (GO:0019083)3.95819209
18ribosomal large subunit biogenesis (GO:0042273)3.95118197
19translational termination (GO:0006415)3.91585095
20spliceosomal tri-snRNP complex assembly (GO:0000244)3.91072947
21DNA replication initiation (GO:0006270)3.87318885
22DNA strand elongation (GO:0022616)3.83863514
23heterochromatin organization (GO:0070828)3.80526776
24translational elongation (GO:0006414)3.73263067
25serine family amino acid biosynthetic process (GO:0009070)3.71523503
26ribosome biogenesis (GO:0042254)3.71047577
27ribonucleoprotein complex biogenesis (GO:0022613)3.65119393
28mitotic sister chromatid segregation (GO:0000070)3.63663180
29IMP metabolic process (GO:0046040)3.62852191
30tetrahydrofolate metabolic process (GO:0046653)3.61334278
31telomere maintenance via semi-conservative replication (GO:0032201)3.59774834
32protein maturation by protein folding (GO:0022417)3.58225531
33pteridine-containing compound biosynthetic process (GO:0042559)3.55769357
34translational initiation (GO:0006413)3.54542724
35ribosomal small subunit biogenesis (GO:0042274)3.51676872
36protein complex localization (GO:0031503)3.49007316
37L-serine metabolic process (GO:0006563)3.48126524
38nucleobase-containing small molecule interconversion (GO:0015949)3.47925729
39histone arginine methylation (GO:0034969)3.42474815
40ribosome assembly (GO:0042255)3.40972550
41apoptotic process involved in morphogenesis (GO:0060561)3.37236536
42folic acid-containing compound metabolic process (GO:0006760)3.37230576
43protein localization to kinetochore (GO:0034501)3.36428266
44serine family amino acid metabolic process (GO:0009069)3.35739043
45nuclear envelope reassembly (GO:0031468)3.30399536
46mitotic nuclear envelope reassembly (GO:0007084)3.30399536
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29652811
48cellular protein complex localization (GO:0034629)3.27235104
49peptidyl-arginine N-methylation (GO:0035246)3.26661761
50peptidyl-arginine methylation (GO:0018216)3.26661761
51pseudouridine synthesis (GO:0001522)3.25788558
52proline metabolic process (GO:0006560)3.24476166
53sister chromatid segregation (GO:0000819)3.20689716
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19600658
55mitotic nuclear envelope disassembly (GO:0007077)3.17102675
56one-carbon metabolic process (GO:0006730)3.16188535
57pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.15391984
58negative regulation of mRNA processing (GO:0050686)3.13477585
59regulation of translational fidelity (GO:0006450)3.13188285
60rRNA processing (GO:0006364)3.13068863
61negative regulation of cell size (GO:0045792)3.12395259
62protein retention in ER lumen (GO:0006621)3.11443377
63maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09965838
64rRNA transcription (GO:0009303)3.09103645
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06098161
66rRNA metabolic process (GO:0016072)3.04750097
67pore complex assembly (GO:0046931)3.03515374
68lysine metabolic process (GO:0006553)3.01992315
69lysine catabolic process (GO:0006554)3.01992315
70negative regulation of mRNA metabolic process (GO:1903312)3.01380060
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01044000
72UMP biosynthetic process (GO:0006222)3.00534302
73pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.00534302
74UMP metabolic process (GO:0046049)3.00534302
75pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.00534302
76serine family amino acid catabolic process (GO:0009071)2.99959903
77chromosome condensation (GO:0030261)2.98635817
78DNA replication checkpoint (GO:0000076)2.97997148
79telomere maintenance via recombination (GO:0000722)2.97741566
80viral mRNA export from host cell nucleus (GO:0046784)2.96921687
81cellular protein complex disassembly (GO:0043624)2.96643924
82viral life cycle (GO:0019058)2.95774357
83protein targeting to ER (GO:0045047)2.95613451
84pteridine-containing compound metabolic process (GO:0042558)2.95435245
85cotranslational protein targeting to membrane (GO:0006613)2.94022380
86chromatin assembly (GO:0031497)2.93227594
87mitochondrial fusion (GO:0008053)2.91675150
88positive regulation of DNA-dependent DNA replication (GO:2000105)2.91402982
89DNA topological change (GO:0006265)2.89985284
90DNA replication-dependent nucleosome organization (GO:0034723)2.89861459
91DNA replication-dependent nucleosome assembly (GO:0006335)2.89861459
92nucleosome disassembly (GO:0006337)2.89492079
93protein-DNA complex disassembly (GO:0032986)2.89492079
94mitochondrial RNA metabolic process (GO:0000959)2.88861303
95nucleoside salvage (GO:0043174)2.88629971
96nuclear envelope disassembly (GO:0051081)2.88389848
97membrane disassembly (GO:0030397)2.88389848
98regulation of early endosome to late endosome transport (GO:2000641)2.88053860
99DNA duplex unwinding (GO:0032508)2.87328467
100pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.87158201
101telomere maintenance via telomere lengthening (GO:0010833)2.84639595
102DNA geometric change (GO:0032392)2.83587864
103negative regulation of RNA splicing (GO:0033119)2.83499874
104establishment of integrated proviral latency (GO:0075713)2.82353609
105activation of Rac GTPase activity (GO:0032863)2.81855577
106mitotic metaphase plate congression (GO:0007080)2.81494375
107establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80131759
108protein localization to chromosome, centromeric region (GO:0071459)2.79942894
109mitotic recombination (GO:0006312)2.79488768
110DNA conformation change (GO:0071103)2.79398580
111protein localization to endoplasmic reticulum (GO:0070972)2.79156818
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79099489
113cysteine metabolic process (GO:0006534)2.78869383
114nuclear pore organization (GO:0006999)2.78846556
115tRNA aminoacylation for protein translation (GO:0006418)2.78029597
116GDP-mannose metabolic process (GO:0019673)2.77393523
117regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76036658
118regulation of translational elongation (GO:0006448)2.75586080
119mRNA stabilization (GO:0048255)2.74813009
120RNA stabilization (GO:0043489)2.74813009
121adherens junction assembly (GO:0034333)2.74737079
122glyoxylate metabolic process (GO:0046487)2.74284724
123protein complex disassembly (GO:0043241)2.74042796
124cellular component biogenesis (GO:0044085)2.72855172
125protein export from nucleus (GO:0006611)2.72443473
126mitochondrial DNA metabolic process (GO:0032042)2.72117020
127peptidyl-arginine omega-N-methylation (GO:0035247)2.71911489
128spliceosomal snRNP assembly (GO:0000387)2.70964281
129focal adhesion assembly (GO:0048041)2.70523333
130cell-substrate adherens junction assembly (GO:0007045)2.70523333
131regulation of translational termination (GO:0006449)2.70251081
132UV protection (GO:0009650)2.69496787
133proline biosynthetic process (GO:0006561)2.68955427
134tRNA aminoacylation (GO:0043039)2.68645771
135amino acid activation (GO:0043038)2.68645771
136positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68367528
137glucose catabolic process (GO:0006007)2.67292695
138L-phenylalanine metabolic process (GO:0006558)2.66554757
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.66554757
140deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.66160867
141translation (GO:0006412)2.66093142
142snRNA metabolic process (GO:0016073)2.65252573
143pentose-phosphate shunt (GO:0006098)2.65193381
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.64923014
1453-UTR-mediated mRNA stabilization (GO:0070935)2.64545643
146regulation of translation in response to stress (GO:0043555)2.63922051
1472-oxoglutarate metabolic process (GO:0006103)2.61838900
148protein localization to endosome (GO:0036010)2.61544040
149ncRNA 3-end processing (GO:0043628)2.61320985
150valine metabolic process (GO:0006573)2.60077187
151macromolecular complex disassembly (GO:0032984)2.59641230
152mitotic G1 DNA damage checkpoint (GO:0031571)2.59576390
153nuclear-transcribed mRNA catabolic process (GO:0000956)2.59195220
154maternal placenta development (GO:0001893)2.57914665
155regulation of RNA export from nucleus (GO:0046831)2.57200957
156nuclear envelope organization (GO:0006998)2.57079119
157nucleotide-excision repair, DNA gap filling (GO:0006297)2.56557841
158nuclear pore complex assembly (GO:0051292)2.55676414
159sulfur amino acid biosynthetic process (GO:0000097)2.54102643
160regulation of gene silencing by RNA (GO:0060966)2.53373135
161regulation of gene silencing by miRNA (GO:0060964)2.53373135
162DNA packaging (GO:0006323)2.52698920
163tRNA methylation (GO:0030488)2.52347188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.75328816
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.31404897
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04923676
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.89746375
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.83280671
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81358502
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.78804761
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66777420
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54102384
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.46014201
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44562145
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39785865
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32870777
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.29745729
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28494958
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25953693
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23348115
18XRN2_22483619_ChIP-Seq_HELA_Human2.19106274
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.16608525
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06490576
21MYC_22102868_ChIP-Seq_BL_Human2.06272209
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.03770965
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03316628
24LXR_22292898_ChIP-Seq_THP-1_Human2.00208685
25* ELK3_25401928_ChIP-Seq_HUVEC_Human1.96019505
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89561173
27AR_21909140_ChIP-Seq_LNCAP_Human1.83508789
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79259118
29DCP1A_22483619_ChIP-Seq_HELA_Human1.77493073
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74895228
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.70255570
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69247693
33RACK7_27058665_Chip-Seq_MCF-7_Human1.69234174
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.68273766
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67824494
36* GABP_19822575_ChIP-Seq_HepG2_Human1.67424846
37VDR_23849224_ChIP-Seq_CD4+_Human1.67307476
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67237260
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66706392
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.66128163
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64455933
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63709030
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62593453
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60670101
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60611956
46CIITA_25753668_ChIP-Seq_RAJI_Human1.58700663
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57644178
48* E2F1_21310950_ChIP-Seq_MCF-7_Human1.55989333
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55289348
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54965260
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.52951346
52* KDM5A_27292631_Chip-Seq_BREAST_Human1.52005961
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51270879
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48274442
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.45669980
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.45554229
57TTF2_22483619_ChIP-Seq_HELA_Human1.45487114
58ZNF263_19887448_ChIP-Seq_K562_Human1.44113409
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42173779
60* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37687745
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37248736
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36869400
63* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36481922
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34885259
65VDR_21846776_ChIP-Seq_THP-1_Human1.33902873
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33333288
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29956792
68KDM2B_26808549_Chip-Seq_DND41_Human1.29639391
69* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29264051
70P68_20966046_ChIP-Seq_HELA_Human1.29059937
71TCF7_22412390_ChIP-Seq_EML_Mouse1.28441318
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27047004
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26366408
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25811505
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25673119
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25264443
77MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23846496
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22536209
79* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21677600
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19457888
81NCOR1_26117541_ChIP-Seq_K562_Human1.19249425
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19186755
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18059225
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.16550447
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.16259903
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16111295
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15903821
88* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14110360
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13083635
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12853887
91* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12457442
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12218866
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11978620
94* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11257857
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10918126
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09523323
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09346018
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08506732
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08138400
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07953623
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07908375
102* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07872461
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07247114
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06754507
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06592785
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06358532
107* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06076907
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05866747
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.05665251
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05425696
111CLOCK_20551151_ChIP-Seq_293T_Human1.03361930
112TFEB_21752829_ChIP-Seq_HELA_Human1.02258772
113* MAF_26560356_Chip-Seq_TH1_Human1.01827198
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01765421
115* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01507667
116* MAF_26560356_Chip-Seq_TH2_Human1.01459193
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01016340
118* KDM2B_26808549_Chip-Seq_K562_Human1.00422572
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99513591
120CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97986242
121TP53_22127205_ChIP-Seq_IMR90_Human0.96420675
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96133106
123TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96130752
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93453380
125TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93431003
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92463722
127* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92394222
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92020094
129LXR_22158963_ChIP-Seq_LIVER_Mouse0.90476461
130ATF3_27146783_Chip-Seq_COLON_Human0.89274095
131* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88889662
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87264681
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86844087
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86400599
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86340255
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83871134
137PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83636826
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83326755
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82729575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.99670818
2MP0003693_abnormal_embryo_hatching3.81033846
3MP0002139_abnormal_hepatobiliary_system3.69828445
4MP0005360_urolithiasis3.49403540
5MP0004957_abnormal_blastocyst_morpholog3.43042705
6MP0002877_abnormal_melanocyte_morpholog3.30677314
7MP0003111_abnormal_nucleus_morphology3.02423275
8MP0010094_abnormal_chromosome_stability2.86126977
9MP0003077_abnormal_cell_cycle2.68702267
10MP0005085_abnormal_gallbladder_physiolo2.62329412
11MP0005365_abnormal_bile_salt2.61280908
12MP0009840_abnormal_foam_cell2.45964433
13MP0008057_abnormal_DNA_replication2.42993735
14MP0003705_abnormal_hypodermis_morpholog2.33708843
15MP0010352_gastrointestinal_tract_polyps2.24626134
16MP0010234_abnormal_vibrissa_follicle2.14746253
17MP0008438_abnormal_cutaneous_collagen2.07421636
18MP0001730_embryonic_growth_arrest2.06363611
19MP0002396_abnormal_hematopoietic_system2.02984085
20MP0008058_abnormal_DNA_repair1.99238184
21MP0001849_ear_inflammation1.98100582
22MP0000678_abnormal_parathyroid_gland1.94805736
23MP0005623_abnormal_meninges_morphology1.93248261
24MP0008007_abnormal_cellular_replicative1.75597469
25MP0004858_abnormal_nervous_system1.74285713
26MP0008875_abnormal_xenobiotic_pharmacok1.72963831
27MP0008932_abnormal_embryonic_tissue1.72324359
28MP0000350_abnormal_cell_proliferation1.64450215
29MP0003567_abnormal_fetal_cardiomyocyte1.63312844
30MP0005501_abnormal_skin_physiology1.62851884
31MP0010329_abnormal_lipoprotein_level1.59839823
32MP0005380_embryogenesis_phenotype1.59631613
33MP0001672_abnormal_embryogenesis/_devel1.59631613
34MP0001661_extended_life_span1.59552797
35MP0005058_abnormal_lysosome_morphology1.55023111
36MP0003984_embryonic_growth_retardation1.53706890
37MP0006036_abnormal_mitochondrial_physio1.52624698
38MP0000490_abnormal_crypts_of1.52538400
39MP0002088_abnormal_embryonic_growth/wei1.51549176
40MP0005332_abnormal_amino_acid1.50665037
41MP0000003_abnormal_adipose_tissue1.49840407
42MP0009278_abnormal_bone_marrow1.48453396
43MP0010030_abnormal_orbit_morphology1.47618708
44MP0005257_abnormal_intraocular_pressure1.46999170
45MP0003186_abnormal_redox_activity1.43822971
46MP0001697_abnormal_embryo_size1.43013513
47MP0003453_abnormal_keratinocyte_physiol1.42544803
48MP0002080_prenatal_lethality1.41213984
49MP0002796_impaired_skin_barrier1.39510207
50MP0000733_abnormal_muscle_development1.39215145
51MP0005319_abnormal_enzyme/_coenzyme1.37985091
52MP0003123_paternal_imprinting1.37577678
53MP0008260_abnormal_autophagy1.37123569
54MP0003252_abnormal_bile_duct1.36760057
55MP0001348_abnormal_lacrimal_gland1.33830914
56MP0000609_abnormal_liver_physiology1.33553555
57MP0004197_abnormal_fetal_growth/weight/1.33480793
58MP0002086_abnormal_extraembryonic_tissu1.32477008
59MP0002060_abnormal_skin_morphology1.31787128
60MP0002249_abnormal_larynx_morphology1.26073528
61MP0003191_abnormal_cellular_cholesterol1.25471050
62MP0004272_abnormal_basement_membrane1.25038899
63MP0010307_abnormal_tumor_latency1.25021283
64MP0006035_abnormal_mitochondrial_morpho1.23142149
65MP0005266_abnormal_metabolism1.20811018
66MP0005083_abnormal_biliary_tract1.20524685
67MP0003718_maternal_effect1.20078736
68MP0003221_abnormal_cardiomyocyte_apopto1.18686903
69MP0000858_altered_metastatic_potential1.18009693
70MP0001764_abnormal_homeostasis1.14777962
71MP0002089_abnormal_postnatal_growth/wei1.13918432
72MP0005621_abnormal_cell_physiology1.13794376
73MP0002085_abnormal_embryonic_tissue1.13733643
74MP0002019_abnormal_tumor_incidence1.13494885
75MP0005670_abnormal_white_adipose1.13380265
76MP0005375_adipose_tissue_phenotype1.12861533
77MP0003315_abnormal_perineum_morphology1.12711901
78MP0002084_abnormal_developmental_patter1.12152417
79MP0000598_abnormal_liver_morphology1.12046123
80MP0002269_muscular_atrophy1.10222280
81MP0001346_abnormal_lacrimal_gland1.08682372
82MP0001666_abnormal_nutrient_absorption1.07741033
83MP0000313_abnormal_cell_death1.06929530
84MP0005666_abnormal_adipose_tissue1.06136063
85MP0000358_abnormal_cell_content/1.03698382
86MP0000759_abnormal_skeletal_muscle1.02514902
87MP0009672_abnormal_birth_weight1.01287096
88MP0005397_hematopoietic_system_phenotyp0.99574758
89MP0001545_abnormal_hematopoietic_system0.99574758
90MP0003786_premature_aging0.97934914
91MP0003091_abnormal_cell_migration0.97630023
92MP0005330_cardiomyopathy0.97153116
93MP0005384_cellular_phenotype0.96696166
94MP0004808_abnormal_hematopoietic_stem0.94221688
95MP0004019_abnormal_vitamin_homeostasis0.92470601
96MP0000751_myopathy0.91758185
97MP0009053_abnormal_anal_canal0.91224750
98MP0004084_abnormal_cardiac_muscle0.90638965
99MP0001216_abnormal_epidermal_layer0.89941858
100MP0004185_abnormal_adipocyte_glucose0.89763483
101MP0005023_abnormal_wound_healing0.88049804
102MP0003385_abnormal_body_wall0.87176792
103MP0005076_abnormal_cell_differentiation0.86128665
104MP0009333_abnormal_splenocyte_physiolog0.85455787
105MP0000467_abnormal_esophagus_morphology0.85281932
106MP0003646_muscle_fatigue0.84565373
107MP0002970_abnormal_white_adipose0.83707816
108MP0004087_abnormal_muscle_fiber0.82897309
109MP0009931_abnormal_skin_appearance0.81913721
110MP0003942_abnormal_urinary_system0.80698716
111MP0000762_abnormal_tongue_morphology0.80418845
112MP0000537_abnormal_urethra_morphology0.80040645
113MP0006054_spinal_hemorrhage0.80008941
114MP0009643_abnormal_urine_homeostasis0.79936569
115MP0001293_anophthalmia0.78930830
116MP0002138_abnormal_hepatobiliary_system0.78919994
117MP0004233_abnormal_muscle_weight0.78623874
118MP0000428_abnormal_craniofacial_morphol0.77970588
119MP0003119_abnormal_digestive_system0.77753549
120MP0009379_abnormal_foot_pigmentation0.77547472
121MP0000477_abnormal_intestine_morphology0.77034616
122MP0000750_abnormal_muscle_regeneration0.76930895
123MP0010630_abnormal_cardiac_muscle0.76910695
124MP0002118_abnormal_lipid_homeostasis0.76724852
125MP0002092_abnormal_eye_morphology0.76111239
126MP0000579_abnormal_nail_morphology0.75660497
127MP0003566_abnormal_cell_adhesion0.75521559
128MP0002722_abnormal_immune_system0.75278380
129MP0004264_abnormal_extraembryonic_tissu0.73750314
130MP0003656_abnormal_erythrocyte_physiolo0.73611434
131MP0005451_abnormal_body_composition0.72827641
132MP0000689_abnormal_spleen_morphology0.72074143
133MP0002697_abnormal_eye_size0.70914581
134MP0001853_heart_inflammation0.70851351
135MP0003115_abnormal_respiratory_system0.70771856
136MP0000703_abnormal_thymus_morphology0.70450376
137MP0005584_abnormal_enzyme/coenzyme_acti0.69998092
138MP0001915_intracranial_hemorrhage0.69890323
139MP0001881_abnormal_mammary_gland0.69545382
140MP0000566_synostosis0.68685327
141MP0005376_homeostasis/metabolism_phenot0.67930409
142MP0000013_abnormal_adipose_tissue0.66954019
143MP0003763_abnormal_thymus_physiology0.65424867
144MP0002111_abnormal_tail_morphology0.63435230
145MP0009763_increased_sensitivity_to0.60622516
146MP0002398_abnormal_bone_marrow0.58355606
147MP0000747_muscle_weakness0.57493500

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.79824887
2Abnormal number of erythroid precursors (HP:0012131)4.22740836
3Hyperacusis (HP:0010780)3.84722115
4Hypobetalipoproteinemia (HP:0003563)3.67640623
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56249513
6Reticulocytopenia (HP:0001896)3.53037565
7Abnormality of pyrimidine metabolism (HP:0004353)3.50956219
8Ulnar bowing (HP:0003031)3.49934230
9Premature rupture of membranes (HP:0001788)3.48747420
10Hyperglycinuria (HP:0003108)3.48179901
11Hyperammonemia (HP:0001987)3.45997766
12Achilles tendon contracture (HP:0001771)3.30051943
13Oral leukoplakia (HP:0002745)3.24958831
14Multiple enchondromatosis (HP:0005701)3.19380042
15Ependymoma (HP:0002888)3.14689522
16Microvesicular hepatic steatosis (HP:0001414)3.09826574
17Abnormality of serine family amino acid metabolism (HP:0010894)3.08950761
18Abnormality of glycine metabolism (HP:0010895)3.08950761
19Macrocytic anemia (HP:0001972)3.06211669
20Intrahepatic cholestasis (HP:0001406)3.05529964
21Hyperglycinemia (HP:0002154)3.05087813
22Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01956724
23Broad distal phalanx of finger (HP:0009836)3.00072151
24Rhabdomyolysis (HP:0003201)2.99106706
25Distal lower limb amyotrophy (HP:0008944)2.97216463
26Dicarboxylic aciduria (HP:0003215)2.95861441
27Abnormality of dicarboxylic acid metabolism (HP:0010995)2.95861441
28Spastic diplegia (HP:0001264)2.89440389
29Progressive muscle weakness (HP:0003323)2.88353671
30Abnormality of the Achilles tendon (HP:0005109)2.86481894
31Xanthomatosis (HP:0000991)2.80262058
32Ragged-red muscle fibers (HP:0003200)2.76468812
33Insomnia (HP:0100785)2.75337784
34Birth length less than 3rd percentile (HP:0003561)2.73633809
35Protrusio acetabuli (HP:0003179)2.72876575
36Deep venous thrombosis (HP:0002625)2.72054557
37Abnormality of serum amino acid levels (HP:0003112)2.66749754
38Hypoglycemic coma (HP:0001325)2.66311961
39Abnormal gallbladder physiology (HP:0012438)2.66268862
40Cholecystitis (HP:0001082)2.66268862
41Selective tooth agenesis (HP:0001592)2.65471375
42Increased connective tissue (HP:0009025)2.63426052
43Pallor (HP:0000980)2.61870781
44Megaloblastic anemia (HP:0001889)2.59798311
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.56627791
46Abnormality of fatty-acid metabolism (HP:0004359)2.55735563
47Ketosis (HP:0001946)2.54524738
48Hypolipoproteinemia (HP:0010981)2.53268363
49Colon cancer (HP:0003003)2.51034000
50Vertebral compression fractures (HP:0002953)2.50681860
51Fragile skin (HP:0001030)2.46157934
52Abnormality of the distal phalanges of the toes (HP:0010182)2.41607349
53Disproportionate tall stature (HP:0001519)2.39549522
54Abnormality of the umbilical cord (HP:0010881)2.38737705
55Abnormality of methionine metabolism (HP:0010901)2.37626473
56Long palpebral fissure (HP:0000637)2.37209657
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.36267895
58Abnormality of reticulocytes (HP:0004312)2.35686822
59Nausea (HP:0002018)2.35502241
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34589883
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34589883
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33333498
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32282584
64Rhabdomyosarcoma (HP:0002859)2.30342454
65Adenoma sebaceum (HP:0009720)2.28480519
66Angiofibromas (HP:0010615)2.28480519
67Thrombocytosis (HP:0001894)2.26931238
68Broad face (HP:0000283)2.26865811
69Microretrognathia (HP:0000308)2.25640275
70Myoglobinuria (HP:0002913)2.23936581
71Elbow flexion contracture (HP:0002987)2.23264379
72Hyperlipoproteinemia (HP:0010980)2.22052705
73Upper limb amyotrophy (HP:0009129)2.21978557
74Distal upper limb amyotrophy (HP:0007149)2.21978557
75Premature skin wrinkling (HP:0100678)2.21641964
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.18841229
77Increased serum lactate (HP:0002151)2.18167090
78Deviation of the thumb (HP:0009603)2.17008331
79Hepatic necrosis (HP:0002605)2.16997355
80Short nail (HP:0001799)2.16810015
81Aplastic anemia (HP:0001915)2.13492784
82Medulloblastoma (HP:0002885)2.13442215
83Abnormality of the anterior horn cell (HP:0006802)2.13406575
84Degeneration of anterior horn cells (HP:0002398)2.13406575
85Patellar dislocation (HP:0002999)2.12058261
86Basal cell carcinoma (HP:0002671)2.11223717
87Proximal placement of thumb (HP:0009623)2.09882839
88Lethargy (HP:0001254)2.08566808
89Spinal rigidity (HP:0003306)2.07978325
90Breast hypoplasia (HP:0003187)2.06859652
91Ankyloglossia (HP:0010296)2.06667306
92Nonimmune hydrops fetalis (HP:0001790)2.06520715
93Truncus arteriosus (HP:0001660)2.05354936
94Delayed CNS myelination (HP:0002188)2.05330405
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05327641
96Biconcave vertebral bodies (HP:0004586)2.05052284
97Stridor (HP:0010307)2.04972026
98Abnormality of nucleobase metabolism (HP:0010932)2.04931809
99Cerebral edema (HP:0002181)2.04772789
100Abnormality of the fetal cardiovascular system (HP:0010948)2.03610224
101Abnormal umbilical cord blood vessels (HP:0011403)2.03610224
102Single umbilical artery (HP:0001195)2.03610224
103Abnormality of glycolysis (HP:0004366)2.02031175
104Increased serum pyruvate (HP:0003542)2.02031175
105Myopathic facies (HP:0002058)2.01783189
106Increased serum ferritin (HP:0003281)2.00385494
107Bowed forearm bones (HP:0003956)2.00369715
108Bowing of the arm (HP:0006488)2.00369715
109Generalized amyotrophy (HP:0003700)1.99744970
110Difficulty climbing stairs (HP:0003551)1.97937185
111Abnormal cartilage morphology (HP:0002763)1.95805715
112Abnormality of oral frenula (HP:0000190)1.95377153
113Lower limb amyotrophy (HP:0007210)1.94457696
114Distal lower limb muscle weakness (HP:0009053)1.93744351
115Abnormality of iron homeostasis (HP:0011031)1.93727462
116Abnormality of the tricuspid valve (HP:0001702)1.93677548
117Dysmetric saccades (HP:0000641)1.92393860
118Rough bone trabeculation (HP:0100670)1.91883760
119Trismus (HP:0000211)1.91813065
120Abnormality of transition element cation homeostasis (HP:0011030)1.91004745
121Abnormality of the calcaneus (HP:0008364)1.90678088
122Increased muscle lipid content (HP:0009058)1.90485894
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90272820
124Abnormality of alanine metabolism (HP:0010916)1.90272820
125Hyperalaninemia (HP:0003348)1.90272820
126Overriding aorta (HP:0002623)1.89035252
127Renal duplication (HP:0000075)1.87538226
128Progressive external ophthalmoplegia (HP:0000590)1.86613811
129Neoplasm of striated muscle (HP:0009728)1.85162104
130Hypoalphalipoproteinemia (HP:0003233)1.83445626
131Cerebral hypomyelination (HP:0006808)1.83291385
132Pointed chin (HP:0000307)1.82935265
133Lactic acidosis (HP:0003128)1.81843600
134Ankle contracture (HP:0006466)1.81468508
135Natal tooth (HP:0000695)1.81170020
136Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81150209
137Abnormal number of incisors (HP:0011064)1.80667917
138Prolonged partial thromboplastin time (HP:0003645)1.80274496
139Increased nuchal translucency (HP:0010880)1.80043072
140Absent thumb (HP:0009777)1.79920780
141Elfin facies (HP:0004428)1.79220468
142Back pain (HP:0003418)1.79164313
143Pseudobulbar signs (HP:0002200)1.79013798
144Premature ovarian failure (HP:0008209)1.78929586
145Hyperbilirubinemia (HP:0002904)1.78715689
146Squamous cell carcinoma (HP:0002860)1.77332003
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.77261798
148CNS demyelination (HP:0007305)1.76155988
149Ketoacidosis (HP:0001993)1.75755414
150Entropion (HP:0000621)1.75446114
151Agnosia (HP:0010524)1.73229107
152Reduced subcutaneous adipose tissue (HP:0003758)1.73179800
153Abnormality of the heme biosynthetic pathway (HP:0010472)1.72680988
154Deep palmar crease (HP:0006191)1.72002568
155Metabolic acidosis (HP:0001942)1.71911701
156Neoplasm of the pancreas (HP:0002894)1.71902903
157Mildly elevated creatine phosphokinase (HP:0008180)1.70056728
158Late onset (HP:0003584)1.69956553
159Hepatocellular necrosis (HP:0001404)1.69931240
160Reticulocytosis (HP:0001923)1.69677029
161Abnormality of the thoracic spine (HP:0100711)1.69618785
162Astrocytoma (HP:0009592)1.69297330
163Abnormality of the astrocytes (HP:0100707)1.69297330
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69108339
165Genu recurvatum (HP:0002816)1.68683715
166Shallow orbits (HP:0000586)1.68612870
167Hypertensive crisis (HP:0100735)1.67905784
168Advanced eruption of teeth (HP:0006288)1.67709674
169Flared metaphyses (HP:0003015)1.66670668
170Proximal tubulopathy (HP:0000114)1.66404030
171Mitral regurgitation (HP:0001653)1.66398366
172Blue sclerae (HP:0000592)1.66289238
173Orthostatic hypotension (HP:0001278)1.66259007
174Hyperthyroidism (HP:0000836)1.65613383
175Flat acetabular roof (HP:0003180)1.65314872
176Rectal prolapse (HP:0002035)1.64852615
177Bladder diverticulum (HP:0000015)1.64808119
178Abnormality of the phalanges of the hallux (HP:0010057)1.64089152
179Self-mutilation (HP:0000742)1.60515074
180Atrophic scars (HP:0001075)1.59721343
181High anterior hairline (HP:0009890)1.58575936
182Testicular atrophy (HP:0000029)1.57968442
183Sparse lateral eyebrow (HP:0005338)1.57837896
184Spinal cord compression (HP:0002176)1.57747889
185Septate vagina (HP:0001153)1.57737809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.91867723
2IRAK33.60306253
3BUB13.33808648
4WEE13.27334530
5EEF2K3.10562195
6EIF2AK13.06698052
7CDC72.99670335
8BCKDK2.87505794
9PKN22.85395622
10NME22.50572086
11RPS6KB22.36872450
12NEK22.28134678
13NEK12.22718330
14PRPF4B2.22685077
15MAP3K102.03838428
16FLT32.01804024
17TRIB32.01456199
18TSSK61.87267065
19MAP2K31.78087538
20ACVR1B1.75694261
21CDK41.72513810
22TTK1.71704358
23MAP3K111.70463451
24MST1R1.66660474
25CDK71.62506072
26EPHA21.60987114
27EIF2AK31.60102250
28TGFBR11.56389716
29MAP3K81.49908138
30CDK121.48762455
31ERN11.46357467
32MAPKAPK31.42770514
33SCYL21.40812260
34ARAF1.36432439
35RPS6KA41.34122654
36PLK11.33823775
37SRPK11.32080572
38KDR1.30646801
39PASK1.30295578
40VRK21.25319766
41DYRK31.25222623
42BRSK21.23918521
43AURKB1.23438602
44STK161.21674955
45ICK1.20828463
46ATR1.18861576
47TESK21.13774802
48PAK41.11256097
49AURKA1.10843088
50TAOK21.10196097
51BRAF1.09839693
52PBK1.07626302
53PIM21.07409059
54SIK11.03993022
55MAP4K11.03132342
56TLK11.02522704
57MAPK111.02104826
58MKNK11.00610516
59PLK40.99931948
60LRRK20.98351024
61PDGFRA0.91711172
62TESK10.91274276
63PRKD30.89194613
64STK100.88187562
65IRAK20.87116915
66BRSK10.86768923
67PTK20.86250783
68VRK10.85380540
69CHEK10.84566658
70ALK0.83444652
71MTOR0.82709139
72GRK60.81546800
73LMTK20.81490506
74PDK40.78144111
75PDK30.78144111
76PIM10.78055054
77MAP3K30.76876454
78CHEK20.76319231
79KSR20.72016029
80TAOK10.71426667
81STK40.71325494
82AKT20.70686687
83RIPK10.68852500
84TTN0.68836021
85CDK60.67722245
86PTK60.67134141
87FGFR40.66967426
88PAK20.66385153
89CDK20.64589263
90MAP3K130.63666191
91MKNK20.62841036
92CSNK2A20.62244018
93MAP2K20.61305755
94MET0.59454456
95PAK10.59208618
96ILK0.57218930
97CLK10.55121870
98ZAP700.53966997
99PDPK10.52639342
100RPS6KA20.52631700
101MAP3K50.51966882
102NTRK10.49646612
103PLK30.49108941
104BMX0.48765260
105CDK90.48473580
106NME10.48111858
107PRKCI0.47854776
108ATM0.46691171
109CSNK2A10.46656788
110MOS0.46003705
111MAP3K10.45421216
112RPS6KA10.44309671
113IRAK40.43841931
114FGFR10.41993815
115PRKD20.40940406
116MAP3K90.40559948
117ABL20.40286101
118BTK0.40263212
119MELK0.39905213
120CSNK1E0.39345799
121CSF1R0.39223354
122CDK11A0.38481470
123LATS20.36719476
124CDK80.36236497
125DAPK30.35447455
126MAP2K60.35396663
127DAPK10.35273344
128JAK30.34872004
129RPS6KC10.33316116
130RPS6KL10.33316116
131RAF10.33072957
132CAMK1D0.32634064
133CDK10.32067568
134RPS6KA60.30390421

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.53704593
2One carbon pool by folate_Homo sapiens_hsa006702.93700106
3Mismatch repair_Homo sapiens_hsa034302.84843211
4Ribosome_Homo sapiens_hsa030102.76632672
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60428426
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.57941428
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25843912
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25789110
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14555283
10Biosynthesis of amino acids_Homo sapiens_hsa012302.13187446
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08037306
12Proteasome_Homo sapiens_hsa030502.05343553
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05121333
14RNA transport_Homo sapiens_hsa030132.01730904
15Spliceosome_Homo sapiens_hsa030401.99100435
16Carbon metabolism_Homo sapiens_hsa012001.90746079
17RNA polymerase_Homo sapiens_hsa030201.90196746
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.87763614
19Selenocompound metabolism_Homo sapiens_hsa004501.87656836
20Base excision repair_Homo sapiens_hsa034101.84932843
21Pyrimidine metabolism_Homo sapiens_hsa002401.81349786
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.78830121
23Chronic myeloid leukemia_Homo sapiens_hsa052201.77758630
24Sulfur relay system_Homo sapiens_hsa041221.76796035
25Fatty acid degradation_Homo sapiens_hsa000711.75803918
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.73894550
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70856229
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69651061
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.68724675
30Nucleotide excision repair_Homo sapiens_hsa034201.62973032
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61422166
32Homologous recombination_Homo sapiens_hsa034401.60803618
33Propanoate metabolism_Homo sapiens_hsa006401.53768033
34Arginine biosynthesis_Homo sapiens_hsa002201.50647190
35Folate biosynthesis_Homo sapiens_hsa007901.48090800
36Pentose phosphate pathway_Homo sapiens_hsa000301.47549303
37Nitrogen metabolism_Homo sapiens_hsa009101.43134809
38Non-small cell lung cancer_Homo sapiens_hsa052231.34183654
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34183574
40Cell cycle_Homo sapiens_hsa041101.33475891
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28319025
42Pancreatic cancer_Homo sapiens_hsa052121.27551728
43Pyruvate metabolism_Homo sapiens_hsa006201.25956447
44Tryptophan metabolism_Homo sapiens_hsa003801.25888629
45Other glycan degradation_Homo sapiens_hsa005111.22648918
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15658884
47Fatty acid metabolism_Homo sapiens_hsa012121.13906785
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09567403
49N-Glycan biosynthesis_Homo sapiens_hsa005101.09198282
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06349446
51Prion diseases_Homo sapiens_hsa050201.04041276
52Fructose and mannose metabolism_Homo sapiens_hsa000511.00600939
53Peroxisome_Homo sapiens_hsa041461.00543412
54beta-Alanine metabolism_Homo sapiens_hsa004100.99612971
55VEGF signaling pathway_Homo sapiens_hsa043700.98964438
56RNA degradation_Homo sapiens_hsa030180.98770873
57Notch signaling pathway_Homo sapiens_hsa043300.97018464
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94036061
59PPAR signaling pathway_Homo sapiens_hsa033200.91136704
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90815974
61MicroRNAs in cancer_Homo sapiens_hsa052060.89349198
62Lysine degradation_Homo sapiens_hsa003100.86696776
63Glutathione metabolism_Homo sapiens_hsa004800.85088418
64Arginine and proline metabolism_Homo sapiens_hsa003300.84736037
65Apoptosis_Homo sapiens_hsa042100.84419998
66Glioma_Homo sapiens_hsa052140.84342775
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82948025
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82189662
69Butanoate metabolism_Homo sapiens_hsa006500.81677549
70Fanconi anemia pathway_Homo sapiens_hsa034600.79796849
71mRNA surveillance pathway_Homo sapiens_hsa030150.78727135
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78449590
73Shigellosis_Homo sapiens_hsa051310.78042661
74Endometrial cancer_Homo sapiens_hsa052130.77410586
75Galactose metabolism_Homo sapiens_hsa000520.75861497
76Phenylalanine metabolism_Homo sapiens_hsa003600.75377685
77mTOR signaling pathway_Homo sapiens_hsa041500.75302824
78Insulin signaling pathway_Homo sapiens_hsa049100.74711899
79Vitamin B6 metabolism_Homo sapiens_hsa007500.74662199
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71426982
81Non-homologous end-joining_Homo sapiens_hsa034500.70144557
82Systemic lupus erythematosus_Homo sapiens_hsa053220.69935906
83Purine metabolism_Homo sapiens_hsa002300.68795185
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68785996
85Complement and coagulation cascades_Homo sapiens_hsa046100.68671800
86Alcoholism_Homo sapiens_hsa050340.67277186
87Prostate cancer_Homo sapiens_hsa052150.66334717
88Fat digestion and absorption_Homo sapiens_hsa049750.66301825
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66113435
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65965130
91AMPK signaling pathway_Homo sapiens_hsa041520.65868124
92Proteoglycans in cancer_Homo sapiens_hsa052050.64989394
93Colorectal cancer_Homo sapiens_hsa052100.64904523
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64347824
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.63569564
96Chemical carcinogenesis_Homo sapiens_hsa052040.63466710
97Hepatitis B_Homo sapiens_hsa051610.63425602
98p53 signaling pathway_Homo sapiens_hsa041150.63087345
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62847910
100ErbB signaling pathway_Homo sapiens_hsa040120.62366296
101Caffeine metabolism_Homo sapiens_hsa002320.60372637
102Focal adhesion_Homo sapiens_hsa045100.60208261
103Renal cell carcinoma_Homo sapiens_hsa052110.58733471
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56996141
105Tyrosine metabolism_Homo sapiens_hsa003500.55590635
106Starch and sucrose metabolism_Homo sapiens_hsa005000.55059976
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.53673365
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53429791
109B cell receptor signaling pathway_Homo sapiens_hsa046620.52921557
110Metabolic pathways_Homo sapiens_hsa011000.50343826
111Vibrio cholerae infection_Homo sapiens_hsa051100.49972383
112Retinol metabolism_Homo sapiens_hsa008300.49514779
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48340412
114Thyroid cancer_Homo sapiens_hsa052160.47888429
115Melanoma_Homo sapiens_hsa052180.47584456
116Vitamin digestion and absorption_Homo sapiens_hsa049770.46423220
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45543459
118Adherens junction_Homo sapiens_hsa045200.44895093
119Basal transcription factors_Homo sapiens_hsa030220.44601544
120Epstein-Barr virus infection_Homo sapiens_hsa051690.43794966
121Basal cell carcinoma_Homo sapiens_hsa052170.42670002
122HIF-1 signaling pathway_Homo sapiens_hsa040660.42662665
123Histidine metabolism_Homo sapiens_hsa003400.41670320
124Hippo signaling pathway_Homo sapiens_hsa043900.40585021
125Herpes simplex infection_Homo sapiens_hsa051680.36390887
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36225470
127Viral carcinogenesis_Homo sapiens_hsa052030.36089687
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35932547
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.33415211
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33333155
131Salmonella infection_Homo sapiens_hsa051320.32714825
132Glycerolipid metabolism_Homo sapiens_hsa005610.28342741
133Bile secretion_Homo sapiens_hsa049760.27847577
134Fatty acid biosynthesis_Homo sapiens_hsa000610.26873731
135Bladder cancer_Homo sapiens_hsa052190.26824705
136Antigen processing and presentation_Homo sapiens_hsa046120.25666008
137Acute myeloid leukemia_Homo sapiens_hsa052210.24943052
138Fatty acid elongation_Homo sapiens_hsa000620.24565085
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23531015
140HTLV-I infection_Homo sapiens_hsa051660.23207197
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22594205
142Parkinsons disease_Homo sapiens_hsa050120.21488317
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21283293
144Small cell lung cancer_Homo sapiens_hsa052220.20440188

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »