ATAD3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)4.76385810
2DNA replication initiation (GO:0006270)4.63543195
3DNA unwinding involved in DNA replication (GO:0006268)4.55533909
4negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.46172480
5spliceosomal tri-snRNP complex assembly (GO:0000244)4.37695188
6apoptotic process involved in morphogenesis (GO:0060561)4.21580318
7ribosome biogenesis (GO:0042254)4.00302718
8peptidyl-arginine omega-N-methylation (GO:0035247)3.99498901
9ribosomal small subunit biogenesis (GO:0042274)3.95732811
10regulation of translational termination (GO:0006449)3.94160962
11mannose metabolic process (GO:0006013)3.93848566
12histone arginine methylation (GO:0034969)3.79255278
13tRNA methylation (GO:0030488)3.76059189
14ncRNA 3-end processing (GO:0043628)3.70095874
15folic acid metabolic process (GO:0046655)3.67906883
16rRNA transcription (GO:0009303)3.67496484
17heterochromatin organization (GO:0070828)3.66765580
18DNA strand elongation involved in DNA replication (GO:0006271)3.62552046
19proline biosynthetic process (GO:0006561)3.61570882
20ribonucleoprotein complex biogenesis (GO:0022613)3.59915769
21regulation of DNA damage checkpoint (GO:2000001)3.58056490
22negative regulation of mRNA processing (GO:0050686)3.55270889
23tRNA modification (GO:0006400)3.53095738
24DNA strand elongation (GO:0022616)3.52170771
25DNA duplex unwinding (GO:0032508)3.50665614
26mitotic chromosome condensation (GO:0007076)3.48254762
27negative regulation of mRNA metabolic process (GO:1903312)3.44780978
28transcription from mitochondrial promoter (GO:0006390)3.43711777
29viral mRNA export from host cell nucleus (GO:0046784)3.41908283
30GDP-mannose metabolic process (GO:0019673)3.39698779
31pseudouridine synthesis (GO:0001522)3.37751343
32protein complex localization (GO:0031503)3.32797185
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.31687355
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27746136
35DNA geometric change (GO:0032392)3.27266349
36formation of translation preinitiation complex (GO:0001731)3.26417529
37mitochondrial RNA metabolic process (GO:0000959)3.24399296
38peptidyl-arginine methylation (GO:0018216)3.24271673
39peptidyl-arginine N-methylation (GO:0035246)3.24271673
40negative regulation of RNA splicing (GO:0033119)3.23790611
41snRNA metabolic process (GO:0016073)3.22957719
42DNA replication checkpoint (GO:0000076)3.19410816
43chromatin assembly (GO:0031497)3.18900969
44maturation of SSU-rRNA (GO:0030490)3.17756750
45pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.13565462
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.07538573
47negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06256713
48nuclear pore complex assembly (GO:0051292)3.06022152
493-UTR-mediated mRNA stabilization (GO:0070935)3.05334847
50cellular protein complex localization (GO:0034629)3.02482828
51negative regulation of cell size (GO:0045792)3.01249092
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.99970054
53pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.99697512
54UMP biosynthetic process (GO:0006222)2.99697512
55pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.99697512
56UMP metabolic process (GO:0046049)2.99697512
57negative regulation of erythrocyte differentiation (GO:0045647)2.99015364
58mitotic nuclear envelope disassembly (GO:0007077)2.93636511
59pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.93068052
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91021816
61telomere maintenance via semi-conservative replication (GO:0032201)2.89457407
62mitotic sister chromatid segregation (GO:0000070)2.87496474
63rRNA processing (GO:0006364)2.86004247
64negative regulation of viral release from host cell (GO:1902187)2.85674455
65snRNA processing (GO:0016180)2.85611581
66folic acid-containing compound biosynthetic process (GO:0009396)2.85561953
67apoptotic process involved in development (GO:1902742)2.85052116
68intracellular estrogen receptor signaling pathway (GO:0030520)2.84229107
69activation of Rac GTPase activity (GO:0032863)2.82450130
70regulation of histone H3-K27 methylation (GO:0061085)2.81125121
71negative regulation of histone methylation (GO:0031061)2.79112950
72DNA conformation change (GO:0071103)2.78239919
73mitotic G1/S transition checkpoint (GO:0044819)2.76964015
74regulation of RNA export from nucleus (GO:0046831)2.75940820
75negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.74659505
76maturation of 5.8S rRNA (GO:0000460)2.73473268
77positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.73471392
78rRNA metabolic process (GO:0016072)2.71800761
79mitochondrial fusion (GO:0008053)2.71491341
80regulation of translational elongation (GO:0006448)2.70052492
81DNA synthesis involved in DNA repair (GO:0000731)2.69742554
82nuclear pore organization (GO:0006999)2.68953284
83regulation of cell cycle checkpoint (GO:1901976)2.68113962
84establishment of apical/basal cell polarity (GO:0035089)2.67697398
85nuclear envelope reassembly (GO:0031468)2.65989582
86mitotic nuclear envelope reassembly (GO:0007084)2.65989582
87RNA stabilization (GO:0043489)2.65352971
88mRNA stabilization (GO:0048255)2.65352971
89nuclear envelope disassembly (GO:0051081)2.65325656
90membrane disassembly (GO:0030397)2.65325656
91NIK/NF-kappaB signaling (GO:0038061)2.63409835
92protein-DNA complex disassembly (GO:0032986)2.63097249
93nucleosome disassembly (GO:0006337)2.63097249
94mitotic G1 DNA damage checkpoint (GO:0031571)2.62374796
95adherens junction assembly (GO:0034333)2.61587222
96DNA replication-dependent nucleosome assembly (GO:0006335)2.59804445
97DNA replication-dependent nucleosome organization (GO:0034723)2.59804445
98regulation of chromatin binding (GO:0035561)2.59596180
99ribosomal large subunit biogenesis (GO:0042273)2.59556836
100protein insertion into membrane (GO:0051205)2.59161225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.77038320
2MYC_22102868_ChIP-Seq_BL_Human3.17511830
3VDR_21846776_ChIP-Seq_THP-1_Human2.95185993
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.61520043
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56523115
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55344951
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53690306
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34598671
9LXR_22292898_ChIP-Seq_THP-1_Human2.19852895
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.10454242
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09899254
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07465349
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01361033
14XRN2_22483619_ChIP-Seq_HELA_Human2.00214657
15* ELK3_25401928_ChIP-Seq_HUVEC_Human1.96915738
16DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96806647
17MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84642073
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79126184
19P68_20966046_ChIP-Seq_HELA_Human1.77670034
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75022869
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67745574
22RACK7_27058665_Chip-Seq_MCF-7_Human1.65378564
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65040913
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63991208
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.62345506
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62291588
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.61644778
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58384658
29* KDM2B_26808549_Chip-Seq_DND41_Human1.55895491
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55317430
31* KDM5A_27292631_Chip-Seq_BREAST_Human1.54391168
32* MAF_26560356_Chip-Seq_TH2_Human1.53727897
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50841136
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48953522
35* GABP_19822575_ChIP-Seq_HepG2_Human1.48920762
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.48575980
37TCF7_22412390_ChIP-Seq_EML_Mouse1.48556908
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48315766
39* SA1_27219007_Chip-Seq_ERYTHROID_Human1.47482769
40CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45528907
41DCP1A_22483619_ChIP-Seq_HELA_Human1.43524534
42* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42377330
43* MAF_26560356_Chip-Seq_TH1_Human1.41318236
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40826503
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38848969
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.38507062
47CIITA_25753668_ChIP-Seq_RAJI_Human1.38161727
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35134314
49BCOR_27268052_Chip-Seq_Bcells_Human1.34212882
50SMC4_20622854_ChIP-Seq_HELA_Human1.34105710
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33831700
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32826179
53TTF2_22483619_ChIP-Seq_HELA_Human1.32603141
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29966101
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29932928
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.29114527
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27830688
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27576475
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26790841
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25393116
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24676180
62* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24331628
63NCOR1_26117541_ChIP-Seq_K562_Human1.23764261
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22994678
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.22309422
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.21220126
67ZNF263_19887448_ChIP-Seq_K562_Human1.21043337
68* PHF8_20622854_ChIP-Seq_HELA_Human1.20608749
69VDR_24763502_ChIP-Seq_THP-1_Human1.20043361
70SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18956757
71UTX_26944678_Chip-Seq_JUKART_Human1.18647487
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18054504
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.17490276
74BCL6_27268052_Chip-Seq_Bcells_Human1.17453486
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.15970686
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15580011
77* CREB1_26743006_Chip-Seq_LNCaP_Human1.15243603
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14270742
79ATF3_27146783_Chip-Seq_COLON_Human1.12888194
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12874687
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12871102
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10447054
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.10225048
84KDM2B_26808549_Chip-Seq_K562_Human1.10183223
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10080112
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.09186941
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08700186
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08298154
89E2F1_20622854_ChIP-Seq_HELA_Human1.08110459
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06872496
91TP53_22127205_ChIP-Seq_IMR90_Human1.06619426
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06618056
93RARA_24833708_ChIP-Seq_LIVER_Mouse1.06405959
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04488640
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.04244616
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03941955
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02926074
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.02827455
99CTCF_21964334_Chip-Seq_Bcells_Human1.01894180
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01843193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.01362382
2MP0003111_abnormal_nucleus_morphology3.65729172
3MP0010094_abnormal_chromosome_stability3.05934403
4MP0005076_abnormal_cell_differentiation2.81696879
5MP0005451_abnormal_body_composition2.78243484
6MP0004185_abnormal_adipocyte_glucose2.75792087
7MP0003077_abnormal_cell_cycle2.55724738
8MP0004957_abnormal_blastocyst_morpholog2.48415862
9MP0003705_abnormal_hypodermis_morpholog2.45481657
10MP0009333_abnormal_splenocyte_physiolog2.44135891
11MP0002254_reproductive_system_inflammat2.18387424
12MP0001849_ear_inflammation2.18006824
13MP0009278_abnormal_bone_marrow2.15902165
14MP0001873_stomach_inflammation2.13375062
15MP0004233_abnormal_muscle_weight2.09692346
16MP0005058_abnormal_lysosome_morphology2.02248463
17MP0000537_abnormal_urethra_morphology2.01564188
18MP0000678_abnormal_parathyroid_gland2.01462628
19MP0001730_embryonic_growth_arrest1.99054568
20MP0008007_abnormal_cellular_replicative1.96040632
21MP0001348_abnormal_lacrimal_gland1.93988015
22MP0003763_abnormal_thymus_physiology1.93148168
23MP0002396_abnormal_hematopoietic_system1.90326226
24MP0008260_abnormal_autophagy1.77527720
25MP0003786_premature_aging1.76713858
26MP0008932_abnormal_embryonic_tissue1.75290254
27MP0003453_abnormal_keratinocyte_physiol1.72280362
28MP0004858_abnormal_nervous_system1.71721204
29MP0000350_abnormal_cell_proliferation1.69157052
30MP0000003_abnormal_adipose_tissue1.66330222
31MP0009840_abnormal_foam_cell1.63548616
32MP0004808_abnormal_hematopoietic_stem1.56471145
33MP0008057_abnormal_DNA_replication1.55067672
34MP0008058_abnormal_DNA_repair1.49592911
35MP0010307_abnormal_tumor_latency1.46732296
36MP0002080_prenatal_lethality1.45552799
37MP0001672_abnormal_embryogenesis/_devel1.45399633
38MP0005380_embryogenesis_phenotype1.45399633
39MP0002089_abnormal_postnatal_growth/wei1.45116947
40MP0001661_extended_life_span1.44889450
41MP0000313_abnormal_cell_death1.35691953
42MP0000490_abnormal_crypts_of1.34594481
43MP0003984_embryonic_growth_retardation1.33320004
44MP0005501_abnormal_skin_physiology1.29583545
45MP0000703_abnormal_thymus_morphology1.28298692
46MP0003436_decreased_susceptibility_to1.28181726
47MP0005666_abnormal_adipose_tissue1.27496485
48MP0003172_abnormal_lysosome_physiology1.27271601
49MP0002877_abnormal_melanocyte_morpholog1.24359339
50MP0005375_adipose_tissue_phenotype1.24050891
51MP0002088_abnormal_embryonic_growth/wei1.22347538
52MP0002086_abnormal_extraembryonic_tissu1.21905107
53MP0000733_abnormal_muscle_development1.21275636
54MP0004947_skin_inflammation1.17606971
55MP0002249_abnormal_larynx_morphology1.16495795
56MP0002796_impaired_skin_barrier1.15277676
57MP0001697_abnormal_embryo_size1.14778823
58MP0010234_abnormal_vibrissa_follicle1.09560953
59MP0002085_abnormal_embryonic_tissue1.08409030
60MP0009672_abnormal_birth_weight1.03819487
61MP0006035_abnormal_mitochondrial_morpho1.03044514
62MP0002398_abnormal_bone_marrow1.02810806
63MP0002019_abnormal_tumor_incidence1.02600489
64MP0001216_abnormal_epidermal_layer0.98580791
65MP0000358_abnormal_cell_content/0.96865455
66MP0000858_altered_metastatic_potential0.94283185
67MP0004197_abnormal_fetal_growth/weight/0.92767734
68MP0002084_abnormal_developmental_patter0.92703704
69MP0005621_abnormal_cell_physiology0.92248373
70MP0002722_abnormal_immune_system0.90196077
71MP0009931_abnormal_skin_appearance0.89453394
72MP0002429_abnormal_blood_cell0.89270457
73MP0002970_abnormal_white_adipose0.89113979
74MP0004381_abnormal_hair_follicle0.87376563
75MP0008961_abnormal_basal_metabolism0.86360645
76MP0003806_abnormal_nucleotide_metabolis0.82951399
77MP0002111_abnormal_tail_morphology0.82029892
78MP0002060_abnormal_skin_morphology0.81848311
79MP0010030_abnormal_orbit_morphology0.80444531
80MP0005384_cellular_phenotype0.76947406
81MP0008995_early_reproductive_senescence0.76786580
82MP0002163_abnormal_gland_morphology0.76069745
83MP0000467_abnormal_esophagus_morphology0.75981134
84MP0000477_abnormal_intestine_morphology0.75867384
85MP0003303_peritoneal_inflammation0.73756102
86MP0000470_abnormal_stomach_morphology0.73004018
87MP0000566_synostosis0.71912574
88MP0003315_abnormal_perineum_morphology0.71556133
89MP0001545_abnormal_hematopoietic_system0.70795594
90MP0005397_hematopoietic_system_phenotyp0.70795594
91MP0000716_abnormal_immune_system0.70700920
92MP0003566_abnormal_cell_adhesion0.70111168
93MP0000689_abnormal_spleen_morphology0.68019329
94MP0000750_abnormal_muscle_regeneration0.67471601
95MP0002210_abnormal_sex_determination0.65490888
96MP0005257_abnormal_intraocular_pressure0.65345355
97MP0000685_abnormal_immune_system0.64711309
98MP0005310_abnormal_salivary_gland0.64094460
99MP0003699_abnormal_female_reproductive0.61445487
100MP0000013_abnormal_adipose_tissue0.61087081

Predicted human phenotypes

RankGene SetZ-score
1Progressive muscle weakness (HP:0003323)3.93238179
2Hyperacusis (HP:0010780)3.45618084
3Ulnar bowing (HP:0003031)3.36854958
4Microvesicular hepatic steatosis (HP:0001414)3.30374827
5Abnormal number of erythroid precursors (HP:0012131)3.16103468
6Selective tooth agenesis (HP:0001592)3.11920571
7Broad distal phalanx of finger (HP:0009836)3.07919631
8Abnormality of cells of the erythroid lineage (HP:0012130)3.03439642
9Ureteral duplication (HP:0000073)2.97070077
10Abnormality of the fingertips (HP:0001211)2.85627877
11Broad face (HP:0000283)2.80086060
12Squamous cell carcinoma (HP:0002860)2.76460680
13Stridor (HP:0010307)2.73057329
14Long palpebral fissure (HP:0000637)2.71482800
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70002376
16Birth length less than 3rd percentile (HP:0003561)2.63992014
17Ragged-red muscle fibers (HP:0003200)2.63473092
18Increased neuronal autofluorescent lipopigment (HP:0002074)2.61452226
19Sparse lateral eyebrow (HP:0005338)2.60275383
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57860503
21Deep palmar crease (HP:0006191)2.51695095
22Breast hypoplasia (HP:0003187)2.50592923
23Achilles tendon contracture (HP:0001771)2.47352920
24Trismus (HP:0000211)2.46286397
25Dysmetric saccades (HP:0000641)2.45873135
26Abnormal number of incisors (HP:0011064)2.43923589
27Truncus arteriosus (HP:0001660)2.41351890
28Colitis (HP:0002583)2.38518405
29Duplicated collecting system (HP:0000081)2.31456443
30Microretrognathia (HP:0000308)2.28209138
31Rectal prolapse (HP:0002035)2.26772062
32Premature skin wrinkling (HP:0100678)2.25608073
33Distal lower limb amyotrophy (HP:0008944)2.25255828
34Disproportionate tall stature (HP:0001519)2.22551752
35Increased cerebral lipofuscin (HP:0011813)2.19141612
36Chromsome breakage (HP:0040012)2.17811259
37Urethral obstruction (HP:0000796)2.17617750
38Homocystinuria (HP:0002156)2.17517142
39Abnormality of homocysteine metabolism (HP:0010919)2.17517142
40Rough bone trabeculation (HP:0100670)2.16621127
41Biconcave vertebral bodies (HP:0004586)2.13545675
42Hypergonadotropic hypogonadism (HP:0000815)2.12982865
43Testicular atrophy (HP:0000029)2.11443449
44Reticulocytopenia (HP:0001896)2.10501118
45Progressive external ophthalmoplegia (HP:0000590)2.08847552
46Intestinal fistula (HP:0100819)2.05916194
47Persistence of primary teeth (HP:0006335)2.05513195
48Self-mutilation (HP:0000742)2.04924695
49Aplasia/Hypoplasia of the patella (HP:0006498)2.03829706
50Premature ovarian failure (HP:0008209)2.03561722
51Patellar aplasia (HP:0006443)2.03489724
52Pointed chin (HP:0000307)2.02493336
53Abnormality of the columella (HP:0009929)2.02463532
54Septate vagina (HP:0001153)2.01904715
55Bowing of the arm (HP:0006488)2.00407787
56Bowed forearm bones (HP:0003956)2.00407787
57Long eyelashes (HP:0000527)2.00378752
58Abnormality of the Achilles tendon (HP:0005109)1.99701131
59Obstructive sleep apnea (HP:0002870)1.99467722
60Myopathic facies (HP:0002058)1.98916333
61Hypoplasia of the pons (HP:0012110)1.98276895
62Thin bony cortex (HP:0002753)1.97027947
63Seborrheic dermatitis (HP:0001051)1.96957351
64Abnormality of the pons (HP:0007361)1.96441832
65Poikiloderma (HP:0001029)1.92281648
66Flared metaphyses (HP:0003015)1.91343548
67Natal tooth (HP:0000695)1.91329708
68Abnormality of the renal collecting system (HP:0004742)1.90508875
69Ureteral stenosis (HP:0000071)1.90320771
70Abnormality of reticulocytes (HP:0004312)1.88104037
71Dislocated radial head (HP:0003083)1.83692425
72Abnormality of DNA repair (HP:0003254)1.83606053
73Optic nerve coloboma (HP:0000588)1.82849769
74Abnormality of cochlea (HP:0000375)1.82232558
75Abnormal trabecular bone morphology (HP:0100671)1.81840972
76Increased serum ferritin (HP:0003281)1.80860545
77Nonimmune hydrops fetalis (HP:0001790)1.80639704
78Abnormality of the thoracic spine (HP:0100711)1.78600212
79Pseudobulbar signs (HP:0002200)1.77985970
80Reticulocytosis (HP:0001923)1.77494893
81Difficulty climbing stairs (HP:0003551)1.76477233
82High anterior hairline (HP:0009890)1.75415486
83Acute lymphatic leukemia (HP:0006721)1.75012114
84Abnormality of pyrimidine metabolism (HP:0004353)1.70276739
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.69178899
86Abnormality of subcutaneous fat tissue (HP:0001001)1.69088700
87Hypertensive crisis (HP:0100735)1.68855886
88Short thumb (HP:0009778)1.68157307
89Impulsivity (HP:0100710)1.66797138
90Horseshoe kidney (HP:0000085)1.66637524
91Abnormality of the radial head (HP:0003995)1.66549830
92Fragile skin (HP:0001030)1.66356578
93J-shaped sella turcica (HP:0002680)1.66129331
94Abnormality of oral frenula (HP:0000190)1.66105644
95Abnormality of the aortic arch (HP:0012303)1.65018851
96Deviation of the thumb (HP:0009603)1.64773447
97Insomnia (HP:0100785)1.63350013
98Underdeveloped nasal alae (HP:0000430)1.62764245
99Pallor (HP:0000980)1.62409537
100Proximal placement of thumb (HP:0009623)1.62264973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.96509931
2EEF2K4.16581345
3SMG14.01020201
4CDK123.57916636
5IRAK33.44085191
6ICK3.18405186
7NME22.95814276
8SIK12.08985473
9PRPF4B2.07402466
10MAP3K102.02099148
11MAP2K31.74011862
12BUB11.67211777
13LMTK21.66928372
14ERN11.57107345
15MAP4K11.56750641
16TLK11.55831820
17MST1R1.35780545
18CDC71.35114423
19CDK41.31233246
20MTOR1.27880806
21PKN21.27046459
22FGFR41.26544909
23NME11.25297058
24RPS6KB21.23634102
25MAPK111.23420224
26IRAK41.23197351
27BMX1.19408072
28CHEK21.18301732
29MAP3K131.12249085
30PIM21.11880774
31TTN1.09809477
32MAP2K21.08955429
33MAP3K111.06240437
34MAP3K141.05867626
35EPHA21.05391201
36CDK71.04533198
37CAMK1D1.01617632
38MAP3K81.01230089
39TAOK20.96923783
40SIK20.96876364
41MAPKAPK30.94792884
42SRPK10.94335190
43CDK80.90932136
44RPS6KC10.88736657
45RPS6KL10.88736657
46CHEK10.87827675
47TESK20.86799112
48TYRO30.86523923
49TSSK60.86231263
50AURKA0.84914779
51PASK0.84059291
52ATR0.83873031
53RPS6KA20.82830915
54PRKD30.81083177
55MAP2K60.80842249
56IRAK20.79582980
57KDR0.79234406
58RPS6KA60.79025718
59PBK0.78436574
60MAPK150.77980849
61PRKD20.77806509
62PRKCI0.75787592
63PTK60.71433786
64ZAK0.68199620
65PIM10.66641275
66BRAF0.65934530
67TAOK10.62437908
68CDC42BPA0.58978546
69JAK30.58419803
70ILK0.57857061
71CDK20.57839819
72HIPK20.57544226
73RPS6KA10.56641115
74PDPK10.53567646
75IKBKB0.52615205
76STK40.51196571
77RPS6KA50.51152707
78PAK40.50155753
79MAP3K60.49407103
80AURKB0.48573017
81CAMK1G0.48020215
82WNK40.47964478
83BRD40.46992071
84TTK0.46766170
85MARK20.46506281
86STK100.43986421
87CDK90.43808981
88TBK10.43511790
89MARK30.43500427
90CDK10.43230123
91MAP3K10.43037753
92CHUK0.42940604
93PTK20.42360593
94MET0.42063880
95IRAK10.40654284
96PAK20.39711540
97NEK20.38620787
98SCYL20.37963211
99AKT20.36499214
100KSR20.36204418

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80916558
2Sulfur relay system_Homo sapiens_hsa041223.49497511
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58141768
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53633008
5Base excision repair_Homo sapiens_hsa034102.42834168
6Spliceosome_Homo sapiens_hsa030402.32544771
7Other glycan degradation_Homo sapiens_hsa005112.20447756
8Pyrimidine metabolism_Homo sapiens_hsa002402.00518314
9Bladder cancer_Homo sapiens_hsa052191.89186740
10mRNA surveillance pathway_Homo sapiens_hsa030151.87372086
11One carbon pool by folate_Homo sapiens_hsa006701.85329399
12Ribosome_Homo sapiens_hsa030101.84591867
13Acute myeloid leukemia_Homo sapiens_hsa052211.82078694
14RNA transport_Homo sapiens_hsa030131.82022364
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.80762610
16RNA polymerase_Homo sapiens_hsa030201.77602740
17Homologous recombination_Homo sapiens_hsa034401.76519325
18Cell cycle_Homo sapiens_hsa041101.66076522
19Chronic myeloid leukemia_Homo sapiens_hsa052201.63050314
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57609016
21Notch signaling pathway_Homo sapiens_hsa043301.52989323
22Selenocompound metabolism_Homo sapiens_hsa004501.52764628
23Fructose and mannose metabolism_Homo sapiens_hsa000511.51774650
24Nucleotide excision repair_Homo sapiens_hsa034201.49350182
25VEGF signaling pathway_Homo sapiens_hsa043701.47848296
26Biosynthesis of amino acids_Homo sapiens_hsa012301.44058839
27Mismatch repair_Homo sapiens_hsa034301.42787148
28Lysine degradation_Homo sapiens_hsa003101.39513479
29Viral carcinogenesis_Homo sapiens_hsa052031.36368830
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.32007375
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27574496
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25438692
33Fanconi anemia pathway_Homo sapiens_hsa034601.21411703
34Folate biosynthesis_Homo sapiens_hsa007901.20455692
35Non-small cell lung cancer_Homo sapiens_hsa052231.15997021
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.12691144
37B cell receptor signaling pathway_Homo sapiens_hsa046621.11085567
38Systemic lupus erythematosus_Homo sapiens_hsa053221.08276067
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07061703
40Epstein-Barr virus infection_Homo sapiens_hsa051691.03012279
41mTOR signaling pathway_Homo sapiens_hsa041501.00260484
42Small cell lung cancer_Homo sapiens_hsa052220.99395830
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98332986
44HTLV-I infection_Homo sapiens_hsa051660.97791785
45Apoptosis_Homo sapiens_hsa042100.95631782
46Non-homologous end-joining_Homo sapiens_hsa034500.93500529
47N-Glycan biosynthesis_Homo sapiens_hsa005100.93471594
48Pentose phosphate pathway_Homo sapiens_hsa000300.91218856
49Vitamin B6 metabolism_Homo sapiens_hsa007500.90701992
50TNF signaling pathway_Homo sapiens_hsa046680.90533008
51Primary immunodeficiency_Homo sapiens_hsa053400.88900619
52Pancreatic cancer_Homo sapiens_hsa052120.88888749
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88619263
54MicroRNAs in cancer_Homo sapiens_hsa052060.87163769
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.86870603
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85270429
57T cell receptor signaling pathway_Homo sapiens_hsa046600.83148505
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82567000
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81856255
60Herpes simplex infection_Homo sapiens_hsa051680.81228716
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.76777095
62Hepatitis B_Homo sapiens_hsa051610.75325865
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74178197
64p53 signaling pathway_Homo sapiens_hsa041150.72460792
65ErbB signaling pathway_Homo sapiens_hsa040120.69894927
66Alcoholism_Homo sapiens_hsa050340.67196235
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66537415
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65790466
69Insulin signaling pathway_Homo sapiens_hsa049100.61967757
70Influenza A_Homo sapiens_hsa051640.61966376
71Purine metabolism_Homo sapiens_hsa002300.61206540
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.60940162
73Shigellosis_Homo sapiens_hsa051310.60749546
74Hepatitis C_Homo sapiens_hsa051600.59062529
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58399076
76Prostate cancer_Homo sapiens_hsa052150.56925568
77Glioma_Homo sapiens_hsa052140.56882061
78AMPK signaling pathway_Homo sapiens_hsa041520.55902636
79Thyroid cancer_Homo sapiens_hsa052160.55388628
80Toxoplasmosis_Homo sapiens_hsa051450.52935806
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.52309012
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51818728
83Colorectal cancer_Homo sapiens_hsa052100.50767420
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.50634712
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48972319
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48609501
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48206276
88Endometrial cancer_Homo sapiens_hsa052130.47716990
89Basal cell carcinoma_Homo sapiens_hsa052170.47621322
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47249413
91Prion diseases_Homo sapiens_hsa050200.47049024
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46725713
93Prolactin signaling pathway_Homo sapiens_hsa049170.46600933
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46513655
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43974357
96Measles_Homo sapiens_hsa051620.42997019
97Insulin resistance_Homo sapiens_hsa049310.41047048
98Galactose metabolism_Homo sapiens_hsa000520.40607650
99Lysosome_Homo sapiens_hsa041420.39750852
100Choline metabolism in cancer_Homo sapiens_hsa052310.39023504

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