ATAD3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.61176596
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.54109185
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.11831208
4magnesium ion transport (GO:0015693)4.62057097
5membrane repolarization during action potential (GO:0086011)4.59915591
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.39901809
7NADH dehydrogenase complex assembly (GO:0010257)4.39901809
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.39901809
9regulation of mesoderm development (GO:2000380)4.29984823
10fat-soluble vitamin catabolic process (GO:0042363)4.22072743
11vitamin catabolic process (GO:0009111)4.22072743
12DNA deamination (GO:0045006)4.13288214
13regulation of skeletal muscle contraction (GO:0014819)3.93488003
14water-soluble vitamin biosynthetic process (GO:0042364)3.92405932
15sulfation (GO:0051923)3.90698087
16DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.87875836
17protein complex biogenesis (GO:0070271)3.83770289
18cellular anion homeostasis (GO:0030002)3.80124512
19regulation of membrane repolarization (GO:0060306)3.70953470
20parturition (GO:0007567)3.59818910
21mitochondrial respiratory chain complex assembly (GO:0033108)3.53299679
22cellular response to exogenous dsRNA (GO:0071360)3.47366038
23DNA damage response, signal transduction resulting in transcription (GO:0042772)3.30716339
24positive regulation of fatty acid oxidation (GO:0046321)3.22414908
25cellular response to electrical stimulus (GO:0071257)3.20417949
26negative regulation of systemic arterial blood pressure (GO:0003085)3.20391478
27membrane repolarization (GO:0086009)3.15564327
28positive regulation of potassium ion transmembrane transport (GO:1901381)3.13486398
29indolalkylamine metabolic process (GO:0006586)3.10691441
30negative regulation of protein localization to cell surface (GO:2000009)3.09837385
31regulation of DNA endoreduplication (GO:0032875)3.08978606
32protein-cofactor linkage (GO:0018065)3.08785964
33trivalent inorganic anion homeostasis (GO:0072506)3.08631140
34phosphate ion homeostasis (GO:0055062)3.08631140
35interleukin-6-mediated signaling pathway (GO:0070102)3.08237127
36detection of light stimulus involved in sensory perception (GO:0050962)3.07561725
37detection of light stimulus involved in visual perception (GO:0050908)3.07561725
38fucose catabolic process (GO:0019317)3.04215085
39L-fucose metabolic process (GO:0042354)3.04215085
40L-fucose catabolic process (GO:0042355)3.04215085
41ovulation cycle (GO:0042698)3.00805152
42regulation of posttranscriptional gene silencing (GO:0060147)3.00643245
43regulation of gene silencing by miRNA (GO:0060964)3.00643245
44regulation of gene silencing by RNA (GO:0060966)3.00643245
45positive regulation of synapse maturation (GO:0090129)2.98008723
46cardiovascular system development (GO:0072358)2.97385065
47protein polyglutamylation (GO:0018095)2.94894832
48indole-containing compound catabolic process (GO:0042436)2.93861719
49indolalkylamine catabolic process (GO:0046218)2.93861719
50tryptophan catabolic process (GO:0006569)2.93861719
51positive regulation of defense response to virus by host (GO:0002230)2.91975328
52negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91588198
53membrane depolarization during action potential (GO:0086010)2.88381956
54kynurenine metabolic process (GO:0070189)2.85852079
55DNA methylation involved in gamete generation (GO:0043046)2.85386940
56regulation of synapse maturation (GO:0090128)2.83139002
57gamma-aminobutyric acid transport (GO:0015812)2.79004082
58regulation of glomerulus development (GO:0090192)2.78041116
59response to xenobiotic stimulus (GO:0009410)2.77321862
60negative regulation of sodium ion transport (GO:0010766)2.75888670
61cellular ketone body metabolic process (GO:0046950)2.73644017
62cellular response to ATP (GO:0071318)2.72523169
63somite development (GO:0061053)2.68933588
64cell proliferation in forebrain (GO:0021846)2.68869694
65preassembly of GPI anchor in ER membrane (GO:0016254)2.68152800
66adaptation of signaling pathway (GO:0023058)2.68134944
67negative regulation of telomere maintenance (GO:0032205)2.67510334
68regulation of potassium ion transmembrane transport (GO:1901379)2.66936335
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63071485
70regulation of hippo signaling (GO:0035330)2.62713049
71serotonin metabolic process (GO:0042428)2.61945358
72neuronal action potential (GO:0019228)2.61137360
73regulation of germinal center formation (GO:0002634)2.60224929
74primary amino compound metabolic process (GO:1901160)2.60177573
75regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56486545
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56265371
77regulation of cell proliferation involved in kidney development (GO:1901722)2.56024054
78rhodopsin mediated signaling pathway (GO:0016056)2.55689269
79action potential (GO:0001508)2.55279893
80response to electrical stimulus (GO:0051602)2.53779149
81indole-containing compound metabolic process (GO:0042430)2.52407221
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.51802703
83purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.51802703
84dentate gyrus development (GO:0021542)2.50251100
85endoderm formation (GO:0001706)2.49160818
86regulation of heart rate by cardiac conduction (GO:0086091)2.48755895
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48199956
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.47981870
89interkinetic nuclear migration (GO:0022027)2.46608091
90interferon-gamma secretion (GO:0072643)2.44926712
91negative regulation of T cell differentiation in thymus (GO:0033085)2.43821598
92vitamin D metabolic process (GO:0042359)2.43658185
93ketone body metabolic process (GO:1902224)2.41788955
94flavonoid metabolic process (GO:0009812)2.40905083
95negative regulation of transcription regulatory region DNA binding (GO:2000678)2.40413426
96potassium ion import (GO:0010107)2.39877073
97regulation of female receptivity (GO:0045924)2.38951820
98regulation of action potential (GO:0098900)2.37219458
99relaxation of cardiac muscle (GO:0055119)2.36885422
100multicellular organism reproduction (GO:0032504)2.36577058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.89433870
2EZH2_22144423_ChIP-Seq_EOC_Human4.05971344
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.98336099
4VDR_22108803_ChIP-Seq_LS180_Human3.38455276
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.98140345
6ZNF274_21170338_ChIP-Seq_K562_Hela2.79873796
7GBX2_23144817_ChIP-Seq_PC3_Human2.67629905
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43019285
9EWS_26573619_Chip-Seq_HEK293_Human2.03024697
10BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97189553
11TAF15_26573619_Chip-Seq_HEK293_Human1.94882948
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91380332
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85288562
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82316276
15IGF1R_20145208_ChIP-Seq_DFB_Human1.79836808
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78791750
17IRF1_19129219_ChIP-ChIP_H3396_Human1.76903429
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72039296
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69717462
20FUS_26573619_Chip-Seq_HEK293_Human1.67503966
21P300_19829295_ChIP-Seq_ESCs_Human1.66904972
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.63815514
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.61913712
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61081166
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.59592555
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57368357
27ER_23166858_ChIP-Seq_MCF-7_Human1.57217556
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53278208
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52318439
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.50392692
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49927417
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44511881
33REST_21632747_ChIP-Seq_MESCs_Mouse1.44494822
34MYC_18940864_ChIP-ChIP_HL60_Human1.41465534
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39662716
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.39425640
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39050606
38RNF2_27304074_Chip-Seq_NSC_Mouse1.37607707
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36323274
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35764063
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34353801
42TCF4_23295773_ChIP-Seq_U87_Human1.32796898
43AR_25329375_ChIP-Seq_VCAP_Human1.32791810
44TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32006829
45STAT3_23295773_ChIP-Seq_U87_Human1.31326668
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31079365
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29841742
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29841742
49CBP_20019798_ChIP-Seq_JUKART_Human1.29654617
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29654617
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29263695
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.26767698
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26767698
54SMAD4_21799915_ChIP-Seq_A2780_Human1.26663733
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24668869
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.24303670
57BCAT_22108803_ChIP-Seq_LS180_Human1.23696550
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23692139
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.23027753
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21227973
61SOX2_19829295_ChIP-Seq_ESCs_Human1.20471781
62NANOG_19829295_ChIP-Seq_ESCs_Human1.20471781
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20386077
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18418994
65TP53_22573176_ChIP-Seq_HFKS_Human1.18238791
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.18172520
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17716852
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15163275
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.14644998
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14065675
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11434272
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11110720
73AR_21572438_ChIP-Seq_LNCaP_Human1.08876106
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08558387
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08022485
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.07402594
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.07352066
78NCOR_22424771_ChIP-Seq_293T_Human1.05453064
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04800896
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02055586
81HOXB7_26014856_ChIP-Seq_BT474_Human1.01964275
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.01584828
83TCF4_22108803_ChIP-Seq_LS180_Human1.01073636
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.00368902
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99698337
86AR_20517297_ChIP-Seq_VCAP_Human0.99646402
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99088044
88SMAD4_21741376_ChIP-Seq_EPCs_Human0.98471781
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.97876934
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96945855
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96520921
92LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96394255
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96183737
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.94591971
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93845783
96AHR_22903824_ChIP-Seq_MCF-7_Human0.93605155
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92711664
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92527627
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92457136
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92234268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.05079085
2MP0005646_abnormal_pituitary_gland2.76819671
3MP0003646_muscle_fatigue2.74984639
4MP0002160_abnormal_reproductive_system2.66535296
5MP0004885_abnormal_endolymph2.55154295
6MP0000569_abnormal_digit_pigmentation2.54570306
7MP0004145_abnormal_muscle_electrophysio2.44349825
8MP0002837_dystrophic_cardiac_calcinosis2.41076885
9MP0001485_abnormal_pinna_reflex2.31949493
10MP0002876_abnormal_thyroid_physiology2.31780938
11MP0001968_abnormal_touch/_nociception2.27454515
12MP0005389_reproductive_system_phenotype2.24727472
13MP0003195_calcinosis2.03859458
14MP0006072_abnormal_retinal_apoptosis2.02899988
15MP0005551_abnormal_eye_electrophysiolog1.97374887
16MP0006292_abnormal_olfactory_placode1.96510350
17MP0004043_abnormal_pH_regulation1.89924481
18MP0002272_abnormal_nervous_system1.87727745
19MP0009046_muscle_twitch1.87652468
20MP0009745_abnormal_behavioral_response1.85764646
21MP0002736_abnormal_nociception_after1.85252093
22MP0008872_abnormal_physiological_respon1.84739608
23MP0002638_abnormal_pupillary_reflex1.77447343
24MP0004142_abnormal_muscle_tone1.77280058
25MP0002138_abnormal_hepatobiliary_system1.75548150
26MP0004019_abnormal_vitamin_homeostasis1.73538343
27MP0000631_abnormal_neuroendocrine_gland1.71943824
28MP0001440_abnormal_grooming_behavior1.70584554
29MP0004130_abnormal_muscle_cell1.67931598
30MP0003879_abnormal_hair_cell1.65163215
31MP0008875_abnormal_xenobiotic_pharmacok1.62996897
32MP0001986_abnormal_taste_sensitivity1.59656184
33MP0003011_delayed_dark_adaptation1.45374311
34MP0005645_abnormal_hypothalamus_physiol1.42866158
35MP0004742_abnormal_vestibular_system1.41620830
36MP0005253_abnormal_eye_physiology1.40805561
37MP0001919_abnormal_reproductive_system1.39812931
38MP0002102_abnormal_ear_morphology1.37121865
39MP0004133_heterotaxia1.35752270
40MP0002064_seizures1.34933765
41MP0004215_abnormal_myocardial_fiber1.34530817
42MP0001765_abnormal_ion_homeostasis1.28130398
43MP0001764_abnormal_homeostasis1.27302163
44MP0000230_abnormal_systemic_arterial1.26250364
45MP0001501_abnormal_sleep_pattern1.25024365
46MP0002234_abnormal_pharynx_morphology1.23400239
47MP0005174_abnormal_tail_pigmentation1.22624410
48MP0002653_abnormal_ependyma_morphology1.20811767
49MP0002572_abnormal_emotion/affect_behav1.19764918
50MP0005084_abnormal_gallbladder_morpholo1.19716572
51MP0001486_abnormal_startle_reflex1.16497889
52MP0006276_abnormal_autonomic_nervous1.14618019
53MP0002735_abnormal_chemical_nociception1.14150457
54MP0003718_maternal_effect1.12010171
55MP0008775_abnormal_heart_ventricle1.09594848
56MP0001905_abnormal_dopamine_level1.08355299
57MP0000013_abnormal_adipose_tissue1.07183230
58MP0002733_abnormal_thermal_nociception1.06802008
59MP0002557_abnormal_social/conspecific_i1.05663396
60MP0002938_white_spotting1.05521334
61MP0002928_abnormal_bile_duct1.04608431
62MP0000049_abnormal_middle_ear1.02118314
63MP0003635_abnormal_synaptic_transmissio1.01310287
64MP0002063_abnormal_learning/memory/cond1.01041826
65MP0001542_abnormal_bone_strength1.00658974
66MP0000026_abnormal_inner_ear1.00492360
67MP0001970_abnormal_pain_threshold0.99890382
68MP0003787_abnormal_imprinting0.99784547
69MP0002089_abnormal_postnatal_growth/wei0.99383436
70MP0010386_abnormal_urinary_bladder0.96622983
71MP0003880_abnormal_central_pattern0.95600197
72MP0001963_abnormal_hearing_physiology0.95154457
73MP0004085_abnormal_heartbeat0.95067043
74MP0001502_abnormal_circadian_rhythm0.92290719
75MP0003119_abnormal_digestive_system0.91953257
76MP0005671_abnormal_response_to0.91816354
77MP0005332_abnormal_amino_acid0.91547616
78MP0002163_abnormal_gland_morphology0.90775879
79MP0002067_abnormal_sensory_capabilities0.90223451
80MP0000427_abnormal_hair_cycle0.87584931
81MP0005195_abnormal_posterior_eye0.86183485
82MP0002909_abnormal_adrenal_gland0.85844405
83MP0002184_abnormal_innervation0.84879579
84MP0009780_abnormal_chondrocyte_physiolo0.83474732
85MP0003136_yellow_coat_color0.82295231
86MP0009250_abnormal_appendicular_skeleto0.81439680
87MP0002752_abnormal_somatic_nervous0.80973217
88MP0000383_abnormal_hair_follicle0.80631922
89MP0005386_behavior/neurological_phenoty0.79506596
90MP0004924_abnormal_behavior0.79506596
91MP0003937_abnormal_limbs/digits/tail_de0.77955077
92MP0002277_abnormal_respiratory_mucosa0.77397638
93MP0003938_abnormal_ear_development0.76858289
94MP0001756_abnormal_urination0.76373878
95MP0005410_abnormal_fertilization0.74658871
96MP0009053_abnormal_anal_canal0.74548791
97MP0001188_hyperpigmentation0.74035942
98MP0002229_neurodegeneration0.73882675
99MP0002693_abnormal_pancreas_physiology0.73485729
100MP0003567_abnormal_fetal_cardiomyocyte0.71741574

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.75145862
2Congenital stationary night blindness (HP:0007642)3.77388819
3Decreased circulating renin level (HP:0003351)3.50232358
4Osteomalacia (HP:0002749)3.48210652
5Pancreatic cysts (HP:0001737)3.47806327
6Abolished electroretinogram (ERG) (HP:0000550)3.34742749
7Molar tooth sign on MRI (HP:0002419)3.21852329
8Abnormality of midbrain morphology (HP:0002418)3.21852329
9Nephronophthisis (HP:0000090)3.08337856
10Pancreatic fibrosis (HP:0100732)3.07711760
11Clumsiness (HP:0002312)3.03585081
12Congenital, generalized hypertrichosis (HP:0004540)2.97165019
13Genetic anticipation (HP:0003743)2.92558389
14Abnormality of alanine metabolism (HP:0010916)2.86693114
15Hyperalaninemia (HP:0003348)2.86693114
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.86693114
17Progressive cerebellar ataxia (HP:0002073)2.83495885
18True hermaphroditism (HP:0010459)2.82629209
19Abnormality of the renal cortex (HP:0011035)2.81258743
20Abnormality of the renal medulla (HP:0100957)2.65881619
21Abnormality of the renal collecting system (HP:0004742)2.62760527
22Abnormal number of erythroid precursors (HP:0012131)2.62189172
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.61422410
24Fibular aplasia (HP:0002990)2.54896992
25Short hallux (HP:0010109)2.50380871
26Polydipsia (HP:0001959)2.47200242
27Abnormal drinking behavior (HP:0030082)2.47200242
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.46824419
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.42668947
30Aplasia/hypoplasia of the uterus (HP:0008684)2.40069248
31Broad-based gait (HP:0002136)2.39499209
32Hypoplasia of the uterus (HP:0000013)2.38627801
33Pendular nystagmus (HP:0012043)2.38453788
34Aplasia/Hypoplasia of the hallux (HP:0008362)2.38065512
35Gaze-evoked nystagmus (HP:0000640)2.34781546
36Vascular calcification (HP:0004934)2.33275209
37Abnormal rod and cone electroretinograms (HP:0008323)2.31425879
38Type II lissencephaly (HP:0007260)2.31182826
39Medial flaring of the eyebrow (HP:0010747)2.30513056
40Renal cortical cysts (HP:0000803)2.27614841
41Abnormality of cells of the erythroid lineage (HP:0012130)2.23444147
42Methylmalonic acidemia (HP:0002912)2.23349059
43Abnormality of the middle phalanges of the toes (HP:0010183)2.23039215
44Attenuation of retinal blood vessels (HP:0007843)2.22329143
45Decreased central vision (HP:0007663)2.18554122
46Small hand (HP:0200055)2.16962830
47Abnormality of renal excretion (HP:0011036)2.16838546
48Acute necrotizing encephalopathy (HP:0006965)2.16823480
49Bony spicule pigmentary retinopathy (HP:0007737)2.16435153
50Furrowed tongue (HP:0000221)2.16053333
51Adactyly (HP:0009776)2.14488377
52Stenosis of the external auditory canal (HP:0000402)2.14389358
53Hypoplasia of the pons (HP:0012110)2.14242930
54Congenital sensorineural hearing impairment (HP:0008527)2.13923650
55Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09858463
56Hypoplasia of the ulna (HP:0003022)2.09760894
57Tubular atrophy (HP:0000092)2.08819905
58Cystic liver disease (HP:0006706)2.08012356
59Metabolic alkalosis (HP:0200114)2.07522368
60Abnormality of renal resorption (HP:0011038)2.07085101
613-Methylglutaconic aciduria (HP:0003535)2.06947284
62Short 1st metacarpal (HP:0010034)2.05748706
63Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.05748706
64Large for gestational age (HP:0001520)2.05745826
65Abnormality of the pons (HP:0007361)2.05531112
66Aplasia/Hypoplasia of the patella (HP:0006498)2.05482744
67Mitochondrial inheritance (HP:0001427)2.02898992
68Increased corneal curvature (HP:0100692)2.02689155
69Keratoconus (HP:0000563)2.02689155
70Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.01481049
71Absent/shortened dynein arms (HP:0200106)2.01321543
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.01321543
73Hyperventilation (HP:0002883)1.99725147
74Short tibia (HP:0005736)1.98278315
75Patellar aplasia (HP:0006443)1.95899430
76Abnormality of renin-angiotensin system (HP:0000847)1.95731673
77Chorioretinal atrophy (HP:0000533)1.94791388
78Symphalangism affecting the phalanges of the hand (HP:0009773)1.92830427
79Progressive macrocephaly (HP:0004481)1.91866780
80Short femoral neck (HP:0100864)1.90962555
81Cardiovascular calcification (HP:0011915)1.89564634
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89392701
83Absent thumb (HP:0009777)1.89105308
84Increased CSF lactate (HP:0002490)1.84497127
85Polyuria (HP:0000103)1.83938103
86Aplasia/Hypoplasia of the ulna (HP:0006495)1.83747989
87Abnormality of the phalanges of the 5th finger (HP:0004213)1.82406832
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.82304635
89Concave nail (HP:0001598)1.81991840
90Asplenia (HP:0001746)1.81794219
91Oligodontia (HP:0000677)1.81494757
92Inability to walk (HP:0002540)1.80111590
93Abnormality of the nasal septum (HP:0000419)1.79019374
94Thyroid-stimulating hormone excess (HP:0002925)1.78854861
95Methylmalonic aciduria (HP:0012120)1.77622508
96Abnormality of the 1st metacarpal (HP:0010009)1.77044389
97Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.76764112
98Male pseudohermaphroditism (HP:0000037)1.76495792
99Aplasia/Hypoplasia of the fibula (HP:0006492)1.76221479
100Abnormal mitochondria in muscle tissue (HP:0008316)1.75452137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.70477878
2TLK14.57260260
3ADRBK23.21110493
4BMPR1B3.11860550
5GRK12.91476673
6TAOK32.87521256
7ZAK2.50902742
8ACVR1B2.41171094
9WNK42.22685088
10PINK12.11855769
11PHKG21.84993780
12PHKG11.84993780
13NUAK11.71168224
14INSRR1.66319772
15SGK21.59334757
16MAP4K21.56628956
17TXK1.52054035
18OXSR11.51279676
19WNK31.43294816
20MAPK131.37595574
21MAPKAPK31.33868271
22STK391.30706562
23SGK4941.27364245
24SGK2231.27364245
25STK161.27231146
26MAP3K41.20696090
27DAPK21.16053748
28TNIK1.14941542
29TAF11.13193715
30MST41.11660917
31ADRBK11.08343428
32CASK1.07780455
33PIK3CA1.06544942
34MAPK151.04628839
35TIE10.98289915
36MAP2K60.97796817
37PRKCG0.97583034
38AKT30.97259837
39MAPKAPK50.94135052
40IKBKB0.91173392
41PAK30.90666998
42NTRK30.90663426
43VRK10.89784205
44TEC0.83381228
45RPS6KA60.81361088
46PLK20.81123128
47STK110.78142989
48PRKCE0.77734438
49GRK70.75360711
50TRPM70.74900536
51SGK30.73641369
52OBSCN0.73614985
53GRK50.73392775
54NLK0.72186348
55PRKACA0.67661473
56NME10.65803918
57MAP2K70.65611210
58MKNK20.64610897
59SGK10.60716558
60PRKCI0.60409094
61PRKAA20.60374344
62CHUK0.59832093
63TGFBR10.59248269
64RPS6KA50.57813834
65MUSK0.57776643
66PKN10.57477747
67DYRK20.57437256
68PRKCQ0.55717202
69CSNK1G20.55573515
70RPS6KA20.54998553
71KIT0.54800447
72BLK0.54392115
73CAMK2A0.53494641
74PRKCH0.50652712
75MARK10.48475593
76PTK2B0.48135286
77CSNK1A10.48133661
78STK38L0.47987029
79SYK0.47694579
80CAMK10.47277258
81TNK20.45978582
82MAP3K90.43775915
83CAMKK20.42693942
84PLK40.42344080
85CSNK1G10.41571646
86MAP2K10.41217042
87PRKCA0.39898145
88WNK10.39633388
89PRKAA10.39119443
90MARK30.38960678
91RPS6KL10.38954787
92RPS6KC10.38954787
93CDK190.38673984
94MAP2K20.37651148
95PRKG10.37631006
96PNCK0.36822443
97CDK90.36593918
98FGFR20.36144861
99ITK0.35124900
100BCKDK0.34110587

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.51973049
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.37135504
3Linoleic acid metabolism_Homo sapiens_hsa005912.36057183
4Phototransduction_Homo sapiens_hsa047442.26211154
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26032127
6Homologous recombination_Homo sapiens_hsa034402.25734449
7Oxidative phosphorylation_Homo sapiens_hsa001902.20939481
8Nicotine addiction_Homo sapiens_hsa050332.13296943
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98525020
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.97702189
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.90125314
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88799002
13Nitrogen metabolism_Homo sapiens_hsa009101.88388672
14Protein export_Homo sapiens_hsa030601.71746478
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70106210
16Basal transcription factors_Homo sapiens_hsa030221.59009640
17Caffeine metabolism_Homo sapiens_hsa002321.58565463
18Parkinsons disease_Homo sapiens_hsa050121.58178392
19Tryptophan metabolism_Homo sapiens_hsa003801.54398442
20Morphine addiction_Homo sapiens_hsa050321.54203884
21RNA polymerase_Homo sapiens_hsa030201.52910749
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48835829
23Vitamin digestion and absorption_Homo sapiens_hsa049771.48462321
24Sulfur metabolism_Homo sapiens_hsa009201.48408553
25Selenocompound metabolism_Homo sapiens_hsa004501.45936203
26Retinol metabolism_Homo sapiens_hsa008301.44101913
27Cardiac muscle contraction_Homo sapiens_hsa042601.40304823
28Insulin secretion_Homo sapiens_hsa049111.38684457
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38395396
30Taste transduction_Homo sapiens_hsa047421.37783889
31Sulfur relay system_Homo sapiens_hsa041221.35088965
32Circadian entrainment_Homo sapiens_hsa047131.31442939
33Chemical carcinogenesis_Homo sapiens_hsa052041.30171063
34Ether lipid metabolism_Homo sapiens_hsa005651.29538917
35Serotonergic synapse_Homo sapiens_hsa047261.27124453
36Glutamatergic synapse_Homo sapiens_hsa047241.25277367
37Fanconi anemia pathway_Homo sapiens_hsa034601.23290046
38Alzheimers disease_Homo sapiens_hsa050101.23250036
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22523662
40Butanoate metabolism_Homo sapiens_hsa006501.21338484
41Asthma_Homo sapiens_hsa053101.20747440
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19500653
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17582181
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16824942
45Ribosome_Homo sapiens_hsa030101.16467527
46Olfactory transduction_Homo sapiens_hsa047401.15447384
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.13436255
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12607053
49Huntingtons disease_Homo sapiens_hsa050161.03917819
50GABAergic synapse_Homo sapiens_hsa047270.99918581
51RNA degradation_Homo sapiens_hsa030180.96432376
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94043898
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.92915756
54Cholinergic synapse_Homo sapiens_hsa047250.92094057
55ABC transporters_Homo sapiens_hsa020100.90435715
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88120940
57Collecting duct acid secretion_Homo sapiens_hsa049660.87774883
58Arachidonic acid metabolism_Homo sapiens_hsa005900.86838425
59Renin secretion_Homo sapiens_hsa049240.86565794
60Calcium signaling pathway_Homo sapiens_hsa040200.86313233
61Systemic lupus erythematosus_Homo sapiens_hsa053220.86166412
62Gastric acid secretion_Homo sapiens_hsa049710.83795179
63Mineral absorption_Homo sapiens_hsa049780.81755459
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78658861
65Ovarian steroidogenesis_Homo sapiens_hsa049130.77814205
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77067943
67Dorso-ventral axis formation_Homo sapiens_hsa043200.75287328
68Histidine metabolism_Homo sapiens_hsa003400.73242707
69Salivary secretion_Homo sapiens_hsa049700.72533818
70Peroxisome_Homo sapiens_hsa041460.72463866
71Type I diabetes mellitus_Homo sapiens_hsa049400.72148827
72Oxytocin signaling pathway_Homo sapiens_hsa049210.71765059
73Dopaminergic synapse_Homo sapiens_hsa047280.70505159
74Glycerolipid metabolism_Homo sapiens_hsa005610.70160739
75Regulation of autophagy_Homo sapiens_hsa041400.70058663
76One carbon pool by folate_Homo sapiens_hsa006700.69711482
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68711897
78Graft-versus-host disease_Homo sapiens_hsa053320.67004833
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.66430801
80Primary immunodeficiency_Homo sapiens_hsa053400.65516620
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64890589
82Amphetamine addiction_Homo sapiens_hsa050310.63880996
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63261771
84Autoimmune thyroid disease_Homo sapiens_hsa053200.62071261
85Allograft rejection_Homo sapiens_hsa053300.60820937
86beta-Alanine metabolism_Homo sapiens_hsa004100.56328723
87Circadian rhythm_Homo sapiens_hsa047100.55146193
88Cocaine addiction_Homo sapiens_hsa050300.54673193
89cAMP signaling pathway_Homo sapiens_hsa040240.54123894
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52611743
91Nucleotide excision repair_Homo sapiens_hsa034200.52207276
92Fatty acid degradation_Homo sapiens_hsa000710.51745781
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50395465
94Melanoma_Homo sapiens_hsa052180.50106899
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48176027
96Fat digestion and absorption_Homo sapiens_hsa049750.46593986
97Rheumatoid arthritis_Homo sapiens_hsa053230.45788070
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45145184
99Purine metabolism_Homo sapiens_hsa002300.43949273
100Propanoate metabolism_Homo sapiens_hsa006400.43513264

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