

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | pyrimidine nucleobase catabolic process (GO:0006208) | 9.23115353 |
| 2 | nucleobase catabolic process (GO:0046113) | 7.00227824 |
| 3 | response to pheromone (GO:0019236) | 6.48901710 |
| 4 | neuron cell-cell adhesion (GO:0007158) | 5.33229855 |
| 5 | cell migration in hindbrain (GO:0021535) | 4.91872210 |
| 6 | neuron recognition (GO:0008038) | 4.73778323 |
| 7 | central nervous system projection neuron axonogenesis (GO:0021952) | 4.61937712 |
| 8 | axonal fasciculation (GO:0007413) | 4.52391239 |
| 9 | gamma-aminobutyric acid transport (GO:0015812) | 4.47739615 |
| 10 | central nervous system myelination (GO:0022010) | 4.44969661 |
| 11 | axon ensheathment in central nervous system (GO:0032291) | 4.44969661 |
| 12 | cerebral cortex radially oriented cell migration (GO:0021799) | 4.38633933 |
| 13 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.29359489 |
| 14 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.24949528 |
| 15 | vocalization behavior (GO:0071625) | 4.19351591 |
| 16 | dendrite morphogenesis (GO:0048813) | 4.08580623 |
| 17 | sequestering of actin monomers (GO:0042989) | 4.05559234 |
| 18 | negative regulation of microtubule polymerization (GO:0031115) | 4.04903625 |
| 19 | dendritic spine morphogenesis (GO:0060997) | 4.03512526 |
| 20 | establishment of mitochondrion localization (GO:0051654) | 4.02262524 |
| 21 | layer formation in cerebral cortex (GO:0021819) | 4.02241264 |
| 22 | positive regulation of mitochondrial fission (GO:0090141) | 3.93415326 |
| 23 | presynaptic membrane assembly (GO:0097105) | 3.86598283 |
| 24 | presynaptic membrane organization (GO:0097090) | 3.81992125 |
| 25 | protein localization to synapse (GO:0035418) | 3.74250001 |
| 26 | auditory behavior (GO:0031223) | 3.69471983 |
| 27 | central nervous system neuron axonogenesis (GO:0021955) | 3.69435110 |
| 28 | behavioral response to nicotine (GO:0035095) | 3.61737475 |
| 29 | postsynaptic membrane organization (GO:0001941) | 3.59026265 |
| 30 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 3.58992331 |
| 31 | negative regulation of axon extension (GO:0030517) | 3.57045323 |
| 32 | limb bud formation (GO:0060174) | 3.55573011 |
| 33 | positive regulation of synapse assembly (GO:0051965) | 3.52988833 |
| 34 | chaperone-mediated protein transport (GO:0072321) | 3.52644633 |
| 35 | negative regulation of axonogenesis (GO:0050771) | 3.51902638 |
| 36 | forebrain neuron differentiation (GO:0021879) | 3.50317241 |
| 37 | retinal ganglion cell axon guidance (GO:0031290) | 3.49960043 |
| 38 | hippocampus development (GO:0021766) | 3.48920733 |
| 39 | regulation of synapse structural plasticity (GO:0051823) | 3.48631603 |
| 40 | negative regulation of axon guidance (GO:1902668) | 3.47931301 |
| 41 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.46716680 |
| 42 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.46052748 |
| 43 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.46052748 |
| 44 | dendrite development (GO:0016358) | 3.45721212 |
| 45 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 3.44039939 |
| 46 | response to auditory stimulus (GO:0010996) | 3.37625385 |
| 47 | regulation of respiratory system process (GO:0044065) | 3.36222971 |
| 48 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.36137297 |
| 49 | regulation of collateral sprouting (GO:0048670) | 3.34961752 |
| 50 | glycosphingolipid biosynthetic process (GO:0006688) | 3.30856356 |
| 51 | synaptic vesicle exocytosis (GO:0016079) | 3.27708218 |
| 52 | protein localization to cilium (GO:0061512) | 3.26452506 |
| 53 | axon extension (GO:0048675) | 3.24507281 |
| 54 | neurofilament cytoskeleton organization (GO:0060052) | 3.23958635 |
| 55 | neural tube formation (GO:0001841) | 3.22244254 |
| 56 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.21536203 |
| 57 | mechanosensory behavior (GO:0007638) | 3.20277857 |
| 58 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.17922403 |
| 59 | mitochondrion transport along microtubule (GO:0047497) | 3.15401993 |
| 60 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.15401993 |
| 61 | neuronal action potential propagation (GO:0019227) | 3.14275591 |
| 62 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.11668339 |
| 63 | transmission of nerve impulse (GO:0019226) | 3.11438597 |
| 64 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.09384743 |
| 65 | synaptic vesicle maturation (GO:0016188) | 3.09024819 |
| 66 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.06608680 |
| 67 | neurotransmitter secretion (GO:0007269) | 3.06526060 |
| 68 | nonmotile primary cilium assembly (GO:0035058) | 3.06329629 |
| 69 | neuron migration (GO:0001764) | 3.04059298 |
| 70 | somite development (GO:0061053) | 3.03736903 |
| 71 | cerebellum development (GO:0021549) | 3.03369381 |
| 72 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.03251781 |
| 73 | regulation of synapse assembly (GO:0051963) | 2.99965426 |
| 74 | regulation of respiratory gaseous exchange (GO:0043576) | 2.99209243 |
| 75 | glutamate receptor signaling pathway (GO:0007215) | 2.97732384 |
| 76 | spinal cord development (GO:0021510) | 2.97204164 |
| 77 | protein polyglutamylation (GO:0018095) | 2.96928067 |
| 78 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 2.95826596 |
| 79 | regulation of feeding behavior (GO:0060259) | 2.94888244 |
| 80 | fatty acid elongation (GO:0030497) | 2.93468605 |
| 81 | glial cell proliferation (GO:0014009) | 2.92413106 |
| 82 | regulation of extent of cell growth (GO:0061387) | 2.91204777 |
| 83 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.90832365 |
| 84 | cerebellar granule cell differentiation (GO:0021707) | 2.88502001 |
| 85 | olfactory bulb development (GO:0021772) | 2.86154195 |
| 86 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.86128577 |
| 87 | exploration behavior (GO:0035640) | 2.82555610 |
| 88 | axonogenesis (GO:0007409) | 2.82439587 |
| 89 | head development (GO:0060322) | 2.82254185 |
| 90 | synapse assembly (GO:0007416) | 2.82216838 |
| 91 | long-chain fatty acid biosynthetic process (GO:0042759) | 2.82131530 |
| 92 | neuronal ion channel clustering (GO:0045161) | 2.82020392 |
| 93 | neuromuscular synaptic transmission (GO:0007274) | 2.82016055 |
| 94 | negative regulation of telomere maintenance (GO:0032205) | 2.81972111 |
| 95 | regulation of vesicle fusion (GO:0031338) | 2.81227378 |
| 96 | regulation of axon guidance (GO:1902667) | 2.81176125 |
| 97 | neuron-neuron synaptic transmission (GO:0007270) | 2.81081969 |
| 98 | negative regulation of neurotransmitter transport (GO:0051589) | 2.80763216 |
| 99 | sympathetic nervous system development (GO:0048485) | 2.79680910 |
| 100 | central nervous system neuron development (GO:0021954) | 2.79179551 |
| 101 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316 | 2.79097325 |
| 102 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.78912053 |
| 103 | locomotory exploration behavior (GO:0035641) | 2.77604720 |
| 104 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.76365747 |
| 105 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.76161441 |
| 106 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.75959910 |
| 107 | nervous system development (GO:0007399) | 2.75780610 |
| 108 | startle response (GO:0001964) | 2.75742362 |
| 109 | neuron projection extension (GO:1990138) | 2.75351616 |
| 110 | cranial nerve morphogenesis (GO:0021602) | 2.75206228 |
| 111 | adult walking behavior (GO:0007628) | 2.75194736 |
| 112 | regulation of axon extension (GO:0030516) | 2.74755756 |
| 113 | cerebral cortex cell migration (GO:0021795) | 2.74171068 |
| 114 | regulation of synapse organization (GO:0050807) | 2.72655407 |
| 115 | regulation of cilium movement (GO:0003352) | 2.71630005 |
| 116 | glycerophospholipid catabolic process (GO:0046475) | 2.71228570 |
| 117 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.71170046 |
| 118 | glutamate secretion (GO:0014047) | 2.69742762 |
| 119 | positive regulation of synapse maturation (GO:0090129) | 2.69235878 |
| 120 | synaptic vesicle endocytosis (GO:0048488) | 2.68344076 |
| 121 | short-term memory (GO:0007614) | 2.68033059 |
| 122 | regulation of synaptic vesicle transport (GO:1902803) | 2.67615767 |
| 123 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.67310835 |
| 124 | membrane hyperpolarization (GO:0060081) | 2.66716747 |
| 125 | regulation of axonogenesis (GO:0050770) | 2.65832546 |
| 126 | regulation of microtubule-based movement (GO:0060632) | 2.65822793 |
| 127 | synaptic transmission, glutamatergic (GO:0035249) | 2.65809269 |
| 128 | regulation of alternative mRNA splicing, via spliceosome (GO:0000381) | 2.64932195 |
| 129 | cerebellar Purkinje cell layer development (GO:0021680) | 2.64544999 |
| 130 | synapse organization (GO:0050808) | 2.64356232 |
| 131 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.62640648 |
| 132 | forebrain neuron development (GO:0021884) | 2.61443411 |
| 133 | neuron projection morphogenesis (GO:0048812) | 2.60825771 |
| 134 | neural nucleus development (GO:0048857) | 2.59647919 |
| 135 | dendritic spine organization (GO:0097061) | 2.59412629 |
| 136 | DNA damage response, detection of DNA damage (GO:0042769) | 2.56240231 |
| 137 | protein insertion into membrane (GO:0051205) | 2.56063335 |
| 138 | cardiac ventricle formation (GO:0003211) | 2.54909194 |
| 139 | cytoskeleton-dependent intracellular transport (GO:0030705) | 2.54636207 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.89989053 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.78813510 |
| 3 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 3.02307823 |
| 4 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.85065409 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.81924799 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.78316428 |
| 7 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.78036382 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.51079879 |
| 9 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.47978118 |
| 10 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.46781133 |
| 11 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.46781133 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.44211385 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.40862571 |
| 14 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.40203690 |
| 15 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.36639887 |
| 16 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.33251199 |
| 17 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.32126784 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.27554210 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.25111470 |
| 20 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.23399790 |
| 21 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.18674990 |
| 22 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.14555865 |
| 23 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.11178199 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.04474673 |
| 25 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 2.04111152 |
| 26 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.02790536 |
| 27 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.94889658 |
| 28 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.89652485 |
| 29 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.87148990 |
| 30 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.86287999 |
| 31 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.83094803 |
| 32 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.76611240 |
| 33 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.75475687 |
| 34 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.75435253 |
| 35 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.73618874 |
| 36 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.73497851 |
| 37 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.71564722 |
| 38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.69667103 |
| 39 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.69168369 |
| 40 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.63336097 |
| 41 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.58014786 |
| 42 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.56465906 |
| 43 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.56089324 |
| 44 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.55255649 |
| 45 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.52089988 |
| 46 | VDR_22108803_ChIP-Seq_LS180_Human | 1.48577112 |
| 47 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.45015271 |
| 48 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.43883483 |
| 49 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.43579335 |
| 50 | P300_19829295_ChIP-Seq_ESCs_Human | 1.37656652 |
| 51 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.35593629 |
| 52 | EWS_26573619_Chip-Seq_HEK293_Human | 1.35222103 |
| 53 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.34663730 |
| 54 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.34026269 |
| 55 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.32377178 |
| 56 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.29135535 |
| 57 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.25346446 |
| 58 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.24435355 |
| 59 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.24395622 |
| 60 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.24395622 |
| 61 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.23940765 |
| 62 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.23940765 |
| 63 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.23444649 |
| 64 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.22759998 |
| 65 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.22430753 |
| 66 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.22359714 |
| 67 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.20411892 |
| 68 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.19453855 |
| 69 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.17915163 |
| 70 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.17693838 |
| 71 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.15945310 |
| 72 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.15508608 |
| 73 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.13952142 |
| 74 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.13768953 |
| 75 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.13290820 |
| 76 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11237344 |
| 77 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.11168338 |
| 78 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.10754750 |
| 79 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.10357248 |
| 80 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.09582217 |
| 81 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.08905880 |
| 82 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.07511279 |
| 83 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.07394822 |
| 84 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.05794008 |
| 85 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05257065 |
| 86 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.04034257 |
| 87 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.02454496 |
| 88 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.01654102 |
| 89 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.01397340 |
| 90 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01274423 |
| 91 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.01193839 |
| 92 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.99441530 |
| 93 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.98588285 |
| 94 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.98504503 |
| 95 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.96778974 |
| 96 | AR_25329375_ChIP-Seq_VCAP_Human | 0.96321938 |
| 97 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.94925299 |
| 98 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.94850985 |
| 99 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.94836171 |
| 100 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.94346287 |
| 101 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.94209833 |
| 102 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.94190720 |
| 103 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.94102786 |
| 104 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.93820889 |
| 105 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.93555839 |
| 106 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.93515018 |
| 107 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.93307501 |
| 108 | STAT3_23295773_ChIP-Seq_U87_Human | 0.93014618 |
| 109 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.92944725 |
| 110 | AR_19668381_ChIP-Seq_PC3_Human | 0.92846056 |
| 111 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.92283490 |
| 112 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.92258981 |
| 113 | POU3F1_26484290_ChIP-Seq_ESCss_Mouse | 0.92115827 |
| 114 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.92101788 |
| 115 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.91651862 |
| 116 | JUN_21703547_ChIP-Seq_K562_Human | 0.91443790 |
| 117 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.91412091 |
| 118 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.90893851 |
| 119 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.90709338 |
| 120 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.90566339 |
| 121 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.90067442 |
| 122 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.89679625 |
| 123 | TCF4_23295773_ChIP-Seq_U87_Human | 0.88643687 |
| 124 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.87210576 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 3.88414192 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 3.82870588 |
| 3 | MP0000778_abnormal_nervous_system | 3.59151348 |
| 4 | MP0005423_abnormal_somatic_nervous | 3.45420297 |
| 5 | MP0006276_abnormal_autonomic_nervous | 2.90454460 |
| 6 | MP0004270_analgesia | 2.86775811 |
| 7 | MP0001529_abnormal_vocalization | 2.82787154 |
| 8 | MP0003635_abnormal_synaptic_transmissio | 2.72877678 |
| 9 | MP0002063_abnormal_learning/memory/cond | 2.58121646 |
| 10 | MP0003122_maternal_imprinting | 2.57748301 |
| 11 | MP0005645_abnormal_hypothalamus_physiol | 2.48855833 |
| 12 | MP0002184_abnormal_innervation | 2.23653066 |
| 13 | MP0001486_abnormal_startle_reflex | 2.20812094 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.06301695 |
| 15 | MP0002064_seizures | 2.06166382 |
| 16 | MP0009745_abnormal_behavioral_response | 2.04621789 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 1.93127743 |
| 18 | MP0002557_abnormal_social/conspecific_i | 1.90004748 |
| 19 | MP0001984_abnormal_olfaction | 1.89878469 |
| 20 | MP0002653_abnormal_ependyma_morphology | 1.85197996 |
| 21 | MP0002102_abnormal_ear_morphology | 1.82384371 |
| 22 | MP0008789_abnormal_olfactory_epithelium | 1.78162263 |
| 23 | MP0005394_taste/olfaction_phenotype | 1.77456351 |
| 24 | MP0005499_abnormal_olfactory_system | 1.77456351 |
| 25 | MP0009046_muscle_twitch | 1.77400350 |
| 26 | MP0002733_abnormal_thermal_nociception | 1.73398235 |
| 27 | MP0000955_abnormal_spinal_cord | 1.72386769 |
| 28 | MP0004811_abnormal_neuron_physiology | 1.70002332 |
| 29 | MP0002272_abnormal_nervous_system | 1.68715197 |
| 30 | MP0001905_abnormal_dopamine_level | 1.68649746 |
| 31 | MP0000631_abnormal_neuroendocrine_gland | 1.65358938 |
| 32 | MP0002882_abnormal_neuron_morphology | 1.64562973 |
| 33 | MP0002638_abnormal_pupillary_reflex | 1.63797546 |
| 34 | MP0001440_abnormal_grooming_behavior | 1.62703885 |
| 35 | MP0000537_abnormal_urethra_morphology | 1.62676524 |
| 36 | MP0002735_abnormal_chemical_nociception | 1.62470527 |
| 37 | MP0001968_abnormal_touch/_nociception | 1.62183624 |
| 38 | MP0003121_genomic_imprinting | 1.61485323 |
| 39 | MP0000566_synostosis | 1.58429089 |
| 40 | MP0006292_abnormal_olfactory_placode | 1.56220786 |
| 41 | MP0004885_abnormal_endolymph | 1.51709742 |
| 42 | MP0005646_abnormal_pituitary_gland | 1.51366601 |
| 43 | MP0002067_abnormal_sensory_capabilities | 1.51128884 |
| 44 | MP0004924_abnormal_behavior | 1.51041198 |
| 45 | MP0005386_behavior/neurological_phenoty | 1.51041198 |
| 46 | MP0002152_abnormal_brain_morphology | 1.50385530 |
| 47 | MP0001970_abnormal_pain_threshold | 1.49000199 |
| 48 | MP0004742_abnormal_vestibular_system | 1.45085940 |
| 49 | MP0003861_abnormal_nervous_system | 1.42833821 |
| 50 | MP0008877_abnormal_DNA_methylation | 1.42603457 |
| 51 | MP0000569_abnormal_digit_pigmentation | 1.41873363 |
| 52 | MP0003329_amyloid_beta_deposits | 1.37039052 |
| 53 | MP0003787_abnormal_imprinting | 1.36224734 |
| 54 | MP0002822_catalepsy | 1.35260213 |
| 55 | MP0003890_abnormal_embryonic-extraembry | 1.33904795 |
| 56 | MP0002751_abnormal_autonomic_nervous | 1.33289471 |
| 57 | MP0002736_abnormal_nociception_after | 1.31631319 |
| 58 | MP0010386_abnormal_urinary_bladder | 1.28855797 |
| 59 | MP0004142_abnormal_muscle_tone | 1.28784209 |
| 60 | MP0002752_abnormal_somatic_nervous | 1.27692727 |
| 61 | MP0002066_abnormal_motor_capabilities/c | 1.25396937 |
| 62 | MP0008569_lethality_at_weaning | 1.23155507 |
| 63 | MP0004133_heterotaxia | 1.23009360 |
| 64 | MP0005187_abnormal_penis_morphology | 1.20573637 |
| 65 | MP0000920_abnormal_myelination | 1.20303402 |
| 66 | MP0001502_abnormal_circadian_rhythm | 1.17549323 |
| 67 | MP0002234_abnormal_pharynx_morphology | 1.17272725 |
| 68 | MP0005253_abnormal_eye_physiology | 1.16424453 |
| 69 | MP0003634_abnormal_glial_cell | 1.15879314 |
| 70 | MP0000049_abnormal_middle_ear | 1.11933312 |
| 71 | MP0006072_abnormal_retinal_apoptosis | 1.10795339 |
| 72 | MP0001986_abnormal_taste_sensitivity | 1.10624545 |
| 73 | MP0002909_abnormal_adrenal_gland | 1.10013977 |
| 74 | MP0000026_abnormal_inner_ear | 1.09585951 |
| 75 | MP0010030_abnormal_orbit_morphology | 1.08234075 |
| 76 | MP0004858_abnormal_nervous_system | 1.08108717 |
| 77 | MP0002938_white_spotting | 1.07430787 |
| 78 | MP0003137_abnormal_impulse_conducting | 1.05103740 |
| 79 | MP0001188_hyperpigmentation | 1.04676980 |
| 80 | MP0003136_yellow_coat_color | 1.02658603 |
| 81 | MP0005084_abnormal_gallbladder_morpholo | 1.01836081 |
| 82 | MP0003011_delayed_dark_adaptation | 1.01671759 |
| 83 | MP0003385_abnormal_body_wall | 1.00680807 |
| 84 | MP0001485_abnormal_pinna_reflex | 1.00387647 |
| 85 | MP0001963_abnormal_hearing_physiology | 0.99972806 |
| 86 | MP0003938_abnormal_ear_development | 0.99136854 |
| 87 | MP0003119_abnormal_digestive_system | 0.98885014 |
| 88 | MP0002233_abnormal_nose_morphology | 0.97483278 |
| 89 | MP0000538_abnormal_urinary_bladder | 0.93926993 |
| 90 | MP0000534_abnormal_ureter_morphology | 0.92218184 |
| 91 | MP0002069_abnormal_eating/drinking_beha | 0.91360144 |
| 92 | MP0003632_abnormal_nervous_system | 0.89743941 |
| 93 | MP0005195_abnormal_posterior_eye | 0.88179217 |
| 94 | MP0004134_abnormal_chest_morphology | 0.84926666 |
| 95 | MP0002229_neurodegeneration | 0.84221063 |
| 96 | MP0005409_darkened_coat_color | 0.83825969 |
| 97 | MP0001299_abnormal_eye_distance/ | 0.81646478 |
| 98 | MP0001270_distended_abdomen | 0.81426957 |
| 99 | MP0002081_perinatal_lethality | 0.81214382 |
| 100 | MP0000647_abnormal_sebaceous_gland | 0.79799634 |
| 101 | MP0002116_abnormal_craniofacial_bone | 0.79796611 |
| 102 | MP0003942_abnormal_urinary_system | 0.78986307 |
| 103 | MP0003755_abnormal_palate_morphology | 0.78909983 |
| 104 | MP0005551_abnormal_eye_electrophysiolog | 0.77217148 |
| 105 | MP0001501_abnormal_sleep_pattern | 0.75206222 |
| 106 | MP0008995_early_reproductive_senescence | 0.74474942 |
| 107 | MP0010770_preweaning_lethality | 0.73349050 |
| 108 | MP0002082_postnatal_lethality | 0.73349050 |
| 109 | MP0002177_abnormal_outer_ear | 0.70757144 |
| 110 | MP0003631_nervous_system_phenotype | 0.70477001 |
| 111 | MP0001177_atelectasis | 0.70078046 |
| 112 | MP0009250_abnormal_appendicular_skeleto | 0.69838117 |
| 113 | MP0000462_abnormal_digestive_system | 0.69802533 |
| 114 | MP0003221_abnormal_cardiomyocyte_apopto | 0.69756421 |
| 115 | MP0001943_abnormal_respiration | 0.69131130 |
| 116 | MP0002249_abnormal_larynx_morphology | 0.69004076 |
| 117 | MP0003937_abnormal_limbs/digits/tail_de | 0.68967054 |
| 118 | MP0010769_abnormal_survival | 0.68931819 |
| 119 | MP0003698_abnormal_male_reproductive | 0.68322154 |
| 120 | MP0005391_vision/eye_phenotype | 0.67426557 |
| 121 | MP0003567_abnormal_fetal_cardiomyocyte | 0.66178034 |
| 122 | MP0001286_abnormal_eye_development | 0.65826934 |
| 123 | MP0001293_anophthalmia | 0.65434973 |
| 124 | MP0002928_abnormal_bile_duct | 0.64215849 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Polyphagia (HP:0002591) | 4.16109925 |
| 2 | Limb dystonia (HP:0002451) | 3.63910175 |
| 3 | Abnormal hair whorl (HP:0010721) | 3.51142200 |
| 4 | Lissencephaly (HP:0001339) | 3.41771181 |
| 5 | Ankle clonus (HP:0011448) | 3.38667470 |
| 6 | Failure to thrive in infancy (HP:0001531) | 3.36463442 |
| 7 | Myokymia (HP:0002411) | 3.28937240 |
| 8 | Focal motor seizures (HP:0011153) | 3.28662179 |
| 9 | Sleep apnea (HP:0010535) | 3.25806799 |
| 10 | Abnormality of the corticospinal tract (HP:0002492) | 3.25136223 |
| 11 | Hyperventilation (HP:0002883) | 3.20434087 |
| 12 | Agitation (HP:0000713) | 3.20340640 |
| 13 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.13504822 |
| 14 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.13504822 |
| 15 | Drooling (HP:0002307) | 3.11124510 |
| 16 | Excessive salivation (HP:0003781) | 3.11124510 |
| 17 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 3.09035864 |
| 18 | Hypoplasia of the brainstem (HP:0002365) | 3.09035864 |
| 19 | Gait imbalance (HP:0002141) | 3.05587325 |
| 20 | Specific learning disability (HP:0001328) | 2.89661271 |
| 21 | Supranuclear gaze palsy (HP:0000605) | 2.80155991 |
| 22 | Epileptic encephalopathy (HP:0200134) | 2.77732231 |
| 23 | True hermaphroditism (HP:0010459) | 2.77072747 |
| 24 | Exotropia (HP:0000577) | 2.73948737 |
| 25 | Spastic gait (HP:0002064) | 2.70954003 |
| 26 | Broad-based gait (HP:0002136) | 2.69741732 |
| 27 | Akinesia (HP:0002304) | 2.68360903 |
| 28 | Neurofibrillary tangles (HP:0002185) | 2.68260384 |
| 29 | Esotropia (HP:0000565) | 2.67519973 |
| 30 | Abnormal eating behavior (HP:0100738) | 2.66998757 |
| 31 | Abnormality of the labia minora (HP:0012880) | 2.66870151 |
| 32 | Focal seizures (HP:0007359) | 2.65561892 |
| 33 | Pachygyria (HP:0001302) | 2.61826010 |
| 34 | Molar tooth sign on MRI (HP:0002419) | 2.56316229 |
| 35 | Abnormality of midbrain morphology (HP:0002418) | 2.56316229 |
| 36 | Pancreatic cysts (HP:0001737) | 2.56071938 |
| 37 | Nephronophthisis (HP:0000090) | 2.51959212 |
| 38 | Megalencephaly (HP:0001355) | 2.49862895 |
| 39 | Pancreatic fibrosis (HP:0100732) | 2.49379140 |
| 40 | Amyotrophic lateral sclerosis (HP:0007354) | 2.47431846 |
| 41 | Protruding tongue (HP:0010808) | 2.43489335 |
| 42 | Progressive inability to walk (HP:0002505) | 2.40554470 |
| 43 | Medial flaring of the eyebrow (HP:0010747) | 2.40412521 |
| 44 | Febrile seizures (HP:0002373) | 2.38562835 |
| 45 | Nephrogenic diabetes insipidus (HP:0009806) | 2.37129551 |
| 46 | Progressive cerebellar ataxia (HP:0002073) | 2.35450858 |
| 47 | Congenital primary aphakia (HP:0007707) | 2.32877668 |
| 48 | Poor suck (HP:0002033) | 2.31027322 |
| 49 | Cerebral hypomyelination (HP:0006808) | 2.27716543 |
| 50 | Amblyopia (HP:0000646) | 2.27388086 |
| 51 | Oligodactyly (hands) (HP:0001180) | 2.25518906 |
| 52 | Absent speech (HP:0001344) | 2.23342338 |
| 53 | Intellectual disability, moderate (HP:0002342) | 2.22752078 |
| 54 | Urinary urgency (HP:0000012) | 2.20914568 |
| 55 | Vaginal atresia (HP:0000148) | 2.20453169 |
| 56 | Anteriorly placed anus (HP:0001545) | 2.18083581 |
| 57 | Truncal ataxia (HP:0002078) | 2.15207386 |
| 58 | Increased serum pyruvate (HP:0003542) | 2.12405399 |
| 59 | Abnormality of glycolysis (HP:0004366) | 2.12405399 |
| 60 | Genital tract atresia (HP:0001827) | 2.11769749 |
| 61 | Type II lissencephaly (HP:0007260) | 2.11474937 |
| 62 | Lower limb muscle weakness (HP:0007340) | 2.10252361 |
| 63 | Mutism (HP:0002300) | 2.08003009 |
| 64 | Hepatoblastoma (HP:0002884) | 2.07518296 |
| 65 | Acute necrotizing encephalopathy (HP:0006965) | 2.07024054 |
| 66 | Polymicrogyria (HP:0002126) | 2.06550534 |
| 67 | Insidious onset (HP:0003587) | 2.03741070 |
| 68 | Termporal pattern (HP:0011008) | 2.03741070 |
| 69 | Peripheral hypomyelination (HP:0007182) | 2.03599549 |
| 70 | Large eyes (HP:0001090) | 2.03400784 |
| 71 | Pendular nystagmus (HP:0012043) | 2.03255575 |
| 72 | Shoulder girdle muscle weakness (HP:0003547) | 2.01549043 |
| 73 | Hypoplasia of the corpus callosum (HP:0002079) | 2.01299104 |
| 74 | Aplasia/Hypoplasia of the lens (HP:0008063) | 2.00684738 |
| 75 | Broad alveolar ridges (HP:0000187) | 2.00281275 |
| 76 | Retinal dysplasia (HP:0007973) | 2.00266884 |
| 77 | Cerebral inclusion bodies (HP:0100314) | 1.98849483 |
| 78 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.97552672 |
| 79 | Abnormality of salivation (HP:0100755) | 1.96714029 |
| 80 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.96344840 |
| 81 | Hypsarrhythmia (HP:0002521) | 1.96152502 |
| 82 | Poor eye contact (HP:0000817) | 1.95105029 |
| 83 | Inability to walk (HP:0002540) | 1.94572789 |
| 84 | Ulnar claw (HP:0001178) | 1.94455844 |
| 85 | Abnormality of the renal medulla (HP:0100957) | 1.94421349 |
| 86 | Split foot (HP:0001839) | 1.94190950 |
| 87 | Hemiparesis (HP:0001269) | 1.93185773 |
| 88 | EEG with generalized epileptiform discharges (HP:0011198) | 1.93106937 |
| 89 | Optic nerve hypoplasia (HP:0000609) | 1.93007192 |
| 90 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.92840873 |
| 91 | Chronic hepatic failure (HP:0100626) | 1.92097645 |
| 92 | High anterior hairline (HP:0009890) | 1.92061922 |
| 93 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.91519562 |
| 94 | Patellar aplasia (HP:0006443) | 1.91229295 |
| 95 | Narrow forehead (HP:0000341) | 1.91097119 |
| 96 | Thickened helices (HP:0000391) | 1.90484780 |
| 97 | Epileptiform EEG discharges (HP:0011182) | 1.89222244 |
| 98 | Dialeptic seizures (HP:0011146) | 1.88706182 |
| 99 | Postaxial hand polydactyly (HP:0001162) | 1.88408764 |
| 100 | Cortical dysplasia (HP:0002539) | 1.87979410 |
| 101 | Growth hormone deficiency (HP:0000824) | 1.87127501 |
| 102 | Abnormality of the lower motor neuron (HP:0002366) | 1.87122813 |
| 103 | Pheochromocytoma (HP:0002666) | 1.86202658 |
| 104 | Alacrima (HP:0000522) | 1.85587265 |
| 105 | Septo-optic dysplasia (HP:0100842) | 1.84375989 |
| 106 | Midline defect of the nose (HP:0004122) | 1.84230222 |
| 107 | Generalized tonic-clonic seizures (HP:0002069) | 1.84149429 |
| 108 | Hyperglycinemia (HP:0002154) | 1.83517289 |
| 109 | Sclerocornea (HP:0000647) | 1.83226049 |
| 110 | Occipital encephalocele (HP:0002085) | 1.82758080 |
| 111 | Anencephaly (HP:0002323) | 1.81983596 |
| 112 | Optic nerve coloboma (HP:0000588) | 1.81034776 |
| 113 | Open mouth (HP:0000194) | 1.80359748 |
| 114 | Absent septum pellucidum (HP:0001331) | 1.79519795 |
| 115 | Gastroesophageal reflux (HP:0002020) | 1.78968866 |
| 116 | Thyroid-stimulating hormone excess (HP:0002925) | 1.78621490 |
| 117 | Focal dystonia (HP:0004373) | 1.78491732 |
| 118 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.77625185 |
| 119 | Partial agenesis of the corpus callosum (HP:0001338) | 1.76881541 |
| 120 | Micropenis (HP:0000054) | 1.76867256 |
| 121 | Progressive macrocephaly (HP:0004481) | 1.76473264 |
| 122 | Muscular hypotonia of the trunk (HP:0008936) | 1.76183106 |
| 123 | Poor coordination (HP:0002370) | 1.75946093 |
| 124 | Broad foot (HP:0001769) | 1.74538966 |
| 125 | Cystic liver disease (HP:0006706) | 1.73215289 |
| 126 | Hip dysplasia (HP:0001385) | 1.72453361 |
| 127 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.72241111 |
| 128 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.72241111 |
| 129 | Decreased testicular size (HP:0008734) | 1.72208648 |
| 130 | Torticollis (HP:0000473) | 1.71913378 |
| 131 | Genetic anticipation (HP:0003743) | 1.71856971 |
| 132 | Scrotal hypoplasia (HP:0000046) | 1.71789444 |
| 133 | Narrow nasal bridge (HP:0000446) | 1.70000435 |
| 134 | Atonic seizures (HP:0010819) | 1.69801824 |
| 135 | Poor speech (HP:0002465) | 1.68957496 |
| 136 | Spastic tetraplegia (HP:0002510) | 1.68547069 |
| 137 | Depression (HP:0000716) | 1.68212239 |
| 138 | Stereotypic behavior (HP:0000733) | 1.68196206 |
| 139 | Sensory axonal neuropathy (HP:0003390) | 1.68055728 |
| 140 | Abnormal social behavior (HP:0012433) | 1.67131126 |
| 141 | Impaired social interactions (HP:0000735) | 1.67131126 |
| 142 | Fetal akinesia sequence (HP:0001989) | 1.66221335 |
| 143 | Labial hypoplasia (HP:0000066) | 1.65074047 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 5.75112746 |
| 2 | DYRK2 | 3.49660053 |
| 3 | WNK3 | 3.07885771 |
| 4 | SIK3 | 3.06076522 |
| 5 | NTRK2 | 3.03330499 |
| 6 | BCR | 2.83680711 |
| 7 | CASK | 2.66317044 |
| 8 | MAPK13 | 2.55514000 |
| 9 | TRIM28 | 2.36375256 |
| 10 | MAP4K2 | 2.33097075 |
| 11 | FGFR2 | 2.32682135 |
| 12 | TNIK | 2.27289873 |
| 13 | UHMK1 | 2.21781563 |
| 14 | MAP2K7 | 2.18804089 |
| 15 | MAP3K4 | 2.15742092 |
| 16 | EPHA3 | 2.11052803 |
| 17 | EPHB2 | 1.99546381 |
| 18 | MINK1 | 1.97748049 |
| 19 | TYRO3 | 1.86184796 |
| 20 | KSR1 | 1.83472593 |
| 21 | BMPR1B | 1.81785133 |
| 22 | ERBB3 | 1.71442574 |
| 23 | LIMK1 | 1.69542303 |
| 24 | ICK | 1.68788464 |
| 25 | PINK1 | 1.56416198 |
| 26 | CDK19 | 1.52332702 |
| 27 | PRPF4B | 1.50695692 |
| 28 | NTRK3 | 1.47632531 |
| 29 | SGK223 | 1.47618223 |
| 30 | SGK494 | 1.47618223 |
| 31 | OXSR1 | 1.46299186 |
| 32 | EPHA4 | 1.41100439 |
| 33 | CSNK1G3 | 1.37046606 |
| 34 | MAP3K9 | 1.35447550 |
| 35 | PKN1 | 1.33029863 |
| 36 | PHKG1 | 1.29420729 |
| 37 | PHKG2 | 1.29420729 |
| 38 | STK39 | 1.28084368 |
| 39 | CSNK1G2 | 1.27213824 |
| 40 | CDK5 | 1.23313771 |
| 41 | CSNK1A1L | 1.21263709 |
| 42 | PAK6 | 1.17968574 |
| 43 | DYRK1B | 1.17242476 |
| 44 | SRPK1 | 1.15457107 |
| 45 | BCKDK | 1.10334969 |
| 46 | SIK2 | 1.04883509 |
| 47 | DYRK1A | 1.04005349 |
| 48 | MAP2K4 | 0.99715953 |
| 49 | IRAK2 | 0.99324080 |
| 50 | CDK18 | 0.94848007 |
| 51 | CSNK1G1 | 0.93186729 |
| 52 | PRKD3 | 0.91754849 |
| 53 | DAPK2 | 0.91559305 |
| 54 | PNCK | 0.88092311 |
| 55 | MARK2 | 0.87913002 |
| 56 | YES1 | 0.87277467 |
| 57 | SGK2 | 0.86784461 |
| 58 | MAP3K12 | 0.84817387 |
| 59 | CDK15 | 0.77653472 |
| 60 | CDK14 | 0.76837861 |
| 61 | RPS6KA4 | 0.75219497 |
| 62 | CAMK2B | 0.75152961 |
| 63 | PAK3 | 0.74436801 |
| 64 | ERBB4 | 0.74351956 |
| 65 | ADRBK2 | 0.72745963 |
| 66 | PRKCZ | 0.70115931 |
| 67 | INSRR | 0.68351510 |
| 68 | CDK11A | 0.67746956 |
| 69 | ROCK2 | 0.67205997 |
| 70 | PLK2 | 0.65100056 |
| 71 | PRKCG | 0.61641885 |
| 72 | NME1 | 0.61500432 |
| 73 | ERBB2 | 0.60001511 |
| 74 | CAMK2A | 0.59291362 |
| 75 | ROCK1 | 0.58749038 |
| 76 | MAP3K6 | 0.58396609 |
| 77 | GRK1 | 0.56290451 |
| 78 | CAMKK2 | 0.54136792 |
| 79 | PRKCE | 0.53384225 |
| 80 | RPS6KA2 | 0.49429139 |
| 81 | BRD4 | 0.47012918 |
| 82 | AKT3 | 0.46760343 |
| 83 | CSNK1A1 | 0.46707194 |
| 84 | PRKAA1 | 0.46609079 |
| 85 | BRAF | 0.45498325 |
| 86 | MAPK9 | 0.44958645 |
| 87 | TESK2 | 0.44387464 |
| 88 | STK16 | 0.44328082 |
| 89 | PRKACA | 0.44018766 |
| 90 | FRK | 0.43632890 |
| 91 | DYRK3 | 0.42736461 |
| 92 | CAMK1G | 0.40435357 |
| 93 | RET | 0.40187681 |
| 94 | RPS6KA5 | 0.39535466 |
| 95 | TSSK6 | 0.39261899 |
| 96 | MAP3K5 | 0.39261039 |
| 97 | SGK3 | 0.38346906 |
| 98 | WNK4 | 0.37944860 |
| 99 | PRKACB | 0.37587482 |
| 100 | NTRK1 | 0.37553787 |
| 101 | CAMKK1 | 0.36525625 |
| 102 | FYN | 0.35855437 |
| 103 | TESK1 | 0.35789789 |
| 104 | ADRBK1 | 0.34597387 |
| 105 | IRAK1 | 0.34346152 |
| 106 | CDK3 | 0.34229137 |
| 107 | FER | 0.31506733 |
| 108 | EPHB1 | 0.30835084 |
| 109 | CAMK1 | 0.29448298 |
| 110 | CAMK4 | 0.29425788 |
| 111 | SGK1 | 0.29377076 |
| 112 | MAPK8 | 0.28988098 |
| 113 | ZAK | 0.28934646 |
| 114 | CAMK2D | 0.27649536 |
| 115 | CCNB1 | 0.27584681 |
| 116 | PRKG1 | 0.26767852 |
| 117 | FGFR1 | 0.26740537 |
| 118 | MAPK4 | 0.25953767 |
| 119 | MAPK15 | 0.25522966 |
| 120 | FES | 0.25077122 |
| 121 | GRK7 | 0.24734620 |
| 122 | MKNK1 | 0.24417630 |
| 123 | RPS6KA3 | 0.24224251 |
| 124 | DAPK1 | 0.24161282 |
| 125 | GSK3B | 0.23693646 |
| 126 | FGR | 0.23513727 |
| 127 | CSNK1E | 0.23131345 |
| 128 | CAMK2G | 0.22965194 |
| 129 | CSNK1D | 0.22744617 |
| 130 | AURKA | 0.21535352 |
| 131 | FGFR4 | 0.21125872 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.82448119 |
| 2 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 3.40326369 |
| 3 | Axon guidance_Homo sapiens_hsa04360 | 3.30999771 |
| 4 | Nicotine addiction_Homo sapiens_hsa05033 | 2.94665755 |
| 5 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.35350888 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.29666189 |
| 7 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 2.24646115 |
| 8 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.16956567 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.09677263 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.01064906 |
| 11 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.00946112 |
| 12 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.92904700 |
| 13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.87443019 |
| 14 | Morphine addiction_Homo sapiens_hsa05032 | 1.86152007 |
| 15 | Circadian entrainment_Homo sapiens_hsa04713 | 1.81125506 |
| 16 | Protein export_Homo sapiens_hsa03060 | 1.78449785 |
| 17 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.68172500 |
| 18 | Taste transduction_Homo sapiens_hsa04742 | 1.67427592 |
| 19 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.62272894 |
| 20 | Cocaine addiction_Homo sapiens_hsa05030 | 1.61318459 |
| 21 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.57343555 |
| 22 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.57335457 |
| 23 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.56349850 |
| 24 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.54373548 |
| 25 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.51545535 |
| 26 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.45403457 |
| 27 | Olfactory transduction_Homo sapiens_hsa04740 | 1.40872979 |
| 28 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.40647869 |
| 29 | Gap junction_Homo sapiens_hsa04540 | 1.39459253 |
| 30 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.34518996 |
| 31 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.34307920 |
| 32 | Colorectal cancer_Homo sapiens_hsa05210 | 1.32694130 |
| 33 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.28416755 |
| 34 | Endometrial cancer_Homo sapiens_hsa05213 | 1.26080290 |
| 35 | Long-term depression_Homo sapiens_hsa04730 | 1.24657556 |
| 36 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.24156882 |
| 37 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.23423663 |
| 38 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.22159194 |
| 39 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.16638496 |
| 40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.14287369 |
| 41 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.14050117 |
| 42 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.11558048 |
| 43 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.11356807 |
| 44 | Phototransduction_Homo sapiens_hsa04744 | 1.10374976 |
| 45 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.10274725 |
| 46 | Insulin secretion_Homo sapiens_hsa04911 | 1.09424834 |
| 47 | Long-term potentiation_Homo sapiens_hsa04720 | 1.07762753 |
| 48 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.03216666 |
| 49 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.01932121 |
| 50 | Melanogenesis_Homo sapiens_hsa04916 | 0.99073376 |
| 51 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.98198013 |
| 52 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.95872056 |
| 53 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.94972719 |
| 54 | Basal transcription factors_Homo sapiens_hsa03022 | 0.90644214 |
| 55 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.88979120 |
| 56 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.88873497 |
| 57 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.88688366 |
| 58 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.86612927 |
| 59 | Alcoholism_Homo sapiens_hsa05034 | 0.84804840 |
| 60 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.84643978 |
| 61 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.83505028 |
| 62 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.82717608 |
| 63 | RNA polymerase_Homo sapiens_hsa03020 | 0.80561003 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.76997071 |
| 65 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.75547639 |
| 66 | Circadian rhythm_Homo sapiens_hsa04710 | 0.74555781 |
| 67 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74554409 |
| 68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.73578132 |
| 69 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.73453588 |
| 70 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.72571311 |
| 71 | Peroxisome_Homo sapiens_hsa04146 | 0.69906942 |
| 72 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.69557303 |
| 73 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.68110184 |
| 74 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.68011215 |
| 75 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.67927441 |
| 76 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.67070108 |
| 77 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.66342660 |
| 78 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.66281728 |
| 79 | Glioma_Homo sapiens_hsa05214 | 0.66154459 |
| 80 | Renin secretion_Homo sapiens_hsa04924 | 0.65741116 |
| 81 | Endocytosis_Homo sapiens_hsa04144 | 0.65346674 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.65303340 |
| 83 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.63507319 |
| 84 | Phagosome_Homo sapiens_hsa04145 | 0.63459909 |
| 85 | Salivary secretion_Homo sapiens_hsa04970 | 0.63020396 |
| 86 | Parkinsons disease_Homo sapiens_hsa05012 | 0.62929091 |
| 87 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.62568335 |
| 88 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.61699256 |
| 89 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.61214677 |
| 90 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.60549003 |
| 91 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.59712347 |
| 92 | Tight junction_Homo sapiens_hsa04530 | 0.59072706 |
| 93 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.58915479 |
| 94 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.58421819 |
| 95 | Alzheimers disease_Homo sapiens_hsa05010 | 0.56720287 |
| 96 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.56550666 |
| 97 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.53980140 |
| 98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.53934111 |
| 99 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.52791504 |
| 100 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.52151579 |
| 101 | RNA degradation_Homo sapiens_hsa03018 | 0.51620309 |
| 102 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.51379834 |
| 103 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.50768386 |
| 104 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49691848 |
| 105 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.49514558 |
| 106 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.49054466 |
| 107 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.48450752 |
| 108 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.46544231 |
| 109 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.44866833 |
| 110 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.44557982 |
| 111 | Huntingtons disease_Homo sapiens_hsa05016 | 0.44019302 |
| 112 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.42597113 |
| 113 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.42354792 |
| 114 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.42202578 |
| 115 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.42070083 |
| 116 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.40258677 |
| 117 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.39950307 |
| 118 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39004085 |
| 119 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.37987838 |
| 120 | Prion diseases_Homo sapiens_hsa05020 | 0.37514104 |
| 121 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.37450167 |
| 122 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.36827799 |
| 123 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.36069327 |
| 124 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.35235793 |
| 125 | Melanoma_Homo sapiens_hsa05218 | 0.34557724 |
| 126 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.33368209 |
| 127 | Sulfur relay system_Homo sapiens_hsa04122 | 0.32618573 |
| 128 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.32042211 |
| 129 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.30066396 |
| 130 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.29597011 |
| 131 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.26595014 |
| 132 | Spliceosome_Homo sapiens_hsa03040 | 0.26439089 |
| 133 | Salmonella infection_Homo sapiens_hsa05132 | 0.23910076 |
| 134 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.21385262 |
| 135 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.20638677 |

