ATCAY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in this gene are associated with cerebellar ataxia, Cayman type. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.12232607
2synaptic vesicle maturation (GO:0016188)5.85446617
3locomotory exploration behavior (GO:0035641)5.69304541
4vocalization behavior (GO:0071625)5.66449388
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.54362549
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43674309
7synaptic vesicle exocytosis (GO:0016079)5.39576928
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.35309026
9neuron cell-cell adhesion (GO:0007158)5.16788746
10regulation of synaptic vesicle exocytosis (GO:2000300)5.10026755
11glutamate secretion (GO:0014047)5.08503827
12regulation of glutamate receptor signaling pathway (GO:1900449)5.01117818
13protein localization to synapse (GO:0035418)4.94964004
14nucleobase catabolic process (GO:0046113)4.72527754
15layer formation in cerebral cortex (GO:0021819)4.68737559
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.65561783
17exploration behavior (GO:0035640)4.64621105
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.60799259
19regulation of synaptic vesicle transport (GO:1902803)4.53474193
20neurotransmitter secretion (GO:0007269)4.45070562
21dendritic spine morphogenesis (GO:0060997)4.36642499
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.34903000
23regulation of neuronal synaptic plasticity (GO:0048168)4.34138733
24regulation of synapse structural plasticity (GO:0051823)4.27326635
25neuronal action potential propagation (GO:0019227)4.26163516
26establishment of mitochondrion localization (GO:0051654)4.20873639
27behavioral response to nicotine (GO:0035095)4.19806616
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18465282
29gamma-aminobutyric acid transport (GO:0015812)4.14933954
30synaptic transmission, glutamatergic (GO:0035249)4.12443089
31neurotransmitter-gated ion channel clustering (GO:0072578)4.09120312
32glutamate receptor signaling pathway (GO:0007215)4.07366718
33neuron recognition (GO:0008038)4.05384122
34proline transport (GO:0015824)3.95224804
35neuron-neuron synaptic transmission (GO:0007270)3.94754671
36axonal fasciculation (GO:0007413)3.76991755
37positive regulation of synapse maturation (GO:0090129)3.76322126
38positive regulation of membrane potential (GO:0045838)3.74349057
39long-term memory (GO:0007616)3.72979752
40postsynaptic membrane organization (GO:0001941)3.71300184
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70649713
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68775873
43neuromuscular synaptic transmission (GO:0007274)3.63812145
44neurotransmitter transport (GO:0006836)3.62011474
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61261077
46transmission of nerve impulse (GO:0019226)3.60071378
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.56365678
48mitochondrion transport along microtubule (GO:0047497)3.56365678
49regulation of dendritic spine morphogenesis (GO:0061001)3.54994942
50dendrite morphogenesis (GO:0048813)3.54740467
51regulation of postsynaptic membrane potential (GO:0060078)3.54263390
52cell migration in hindbrain (GO:0021535)3.49769693
53synaptic vesicle endocytosis (GO:0048488)3.47413164
54cellular potassium ion homeostasis (GO:0030007)3.44179719
55regulation of synaptic plasticity (GO:0048167)3.43533601
56activation of protein kinase A activity (GO:0034199)3.41271715
57mechanosensory behavior (GO:0007638)3.40908114
58auditory behavior (GO:0031223)3.40534063
59regulation of neurotransmitter secretion (GO:0046928)3.40022941
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.39624954
61axon ensheathment in central nervous system (GO:0032291)3.38784728
62central nervous system myelination (GO:0022010)3.38784728
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36894826
64neurofilament cytoskeleton organization (GO:0060052)3.36636793
65regulation of neurotransmitter levels (GO:0001505)3.34309141
66presynaptic membrane assembly (GO:0097105)3.34165077
67neuromuscular process controlling balance (GO:0050885)3.32174176
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.28881024
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28122426
70long-term synaptic potentiation (GO:0060291)3.27265690
71response to auditory stimulus (GO:0010996)3.22970126
72cerebellar Purkinje cell differentiation (GO:0021702)3.22347004
73presynaptic membrane organization (GO:0097090)3.22319056
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.22233882
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21384046
76synapse assembly (GO:0007416)3.19554563
77regulation of vesicle fusion (GO:0031338)3.18742924
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18549195
79adult walking behavior (GO:0007628)3.17814795
80sodium ion export (GO:0071436)3.15166360
81prepulse inhibition (GO:0060134)3.14805991
82adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.14141026
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13900196
84regulation of neurotransmitter transport (GO:0051588)3.12970479
85membrane depolarization (GO:0051899)3.11987836
86neuronal ion channel clustering (GO:0045161)3.11851949
87membrane hyperpolarization (GO:0060081)3.11029646
88positive regulation of synapse assembly (GO:0051965)3.09662749
89regulation of dendritic spine development (GO:0060998)3.09277576
90positive regulation of dendritic spine development (GO:0060999)3.08616252
91learning (GO:0007612)3.08334385
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07744671
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07622298
94intraspecies interaction between organisms (GO:0051703)3.06987308
95social behavior (GO:0035176)3.06987308
96central nervous system projection neuron axonogenesis (GO:0021952)3.06960298
97membrane depolarization during action potential (GO:0086010)3.05191864
98pyrimidine nucleobase catabolic process (GO:0006208)3.03846676
99positive regulation of neurotransmitter secretion (GO:0001956)3.03704072
100glycine transport (GO:0015816)3.03254672
101synapse organization (GO:0050808)3.03136244
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02647502
103cerebellar granule cell differentiation (GO:0021707)3.02531557
104cell communication by electrical coupling (GO:0010644)3.02476935
105positive regulation of neurotransmitter transport (GO:0051590)3.01950049
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00818697
107vesicle transport along microtubule (GO:0047496)3.00544569
108regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99468970
109negative regulation of microtubule polymerization (GO:0031115)2.99414356
110regulation of synapse maturation (GO:0090128)2.98180576
111mating behavior (GO:0007617)2.96607016
112regulation of respiratory system process (GO:0044065)2.96464175
113regulation of voltage-gated calcium channel activity (GO:1901385)2.96416115
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96132932
115dendritic spine organization (GO:0097061)2.96099270
116response to histamine (GO:0034776)2.96090887
117organelle transport along microtubule (GO:0072384)2.95812931
118synaptic transmission (GO:0007268)2.92947233
119startle response (GO:0001964)2.91888781
120glycosphingolipid biosynthetic process (GO:0006688)2.82344023
121potassium ion homeostasis (GO:0055075)2.75809980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09239327
2GBX2_23144817_ChIP-Seq_PC3_Human3.55627666
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16890973
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13193928
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02823217
6REST_21632747_ChIP-Seq_MESCs_Mouse2.85270094
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75211646
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75211646
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66646784
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.63759635
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58902260
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.55101721
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53985816
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53408968
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50918826
16* DROSHA_22980978_ChIP-Seq_HELA_Human2.49601315
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48422842
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40341606
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.35732567
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.35465172
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33467074
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.27322865
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.23162618
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22413876
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98183263
26AR_21572438_ChIP-Seq_LNCaP_Human1.96927743
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96046448
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92323450
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90832908
30* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85682760
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82152360
32TAF15_26573619_Chip-Seq_HEK293_Human1.72845711
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68527299
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67811309
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56852666
36SMAD4_21799915_ChIP-Seq_A2780_Human1.56359540
37ZNF274_21170338_ChIP-Seq_K562_Hela1.55091227
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.50310395
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46719582
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42185268
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38561935
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.37672617
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.34516127
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.33712427
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32935245
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32077668
47P300_19829295_ChIP-Seq_ESCs_Human1.30118892
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29187210
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28117508
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27572639
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.27118257
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22165778
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20636382
54AR_25329375_ChIP-Seq_VCAP_Human1.20453784
55IGF1R_20145208_ChIP-Seq_DFB_Human1.19855610
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19779060
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19610867
58AR_19668381_ChIP-Seq_PC3_Human1.19267850
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18726795
60RNF2_27304074_Chip-Seq_NSC_Mouse1.18154567
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.18036984
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.16494416
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16343794
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15990645
65* STAT3_23295773_ChIP-Seq_U87_Human1.14596657
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14440212
67VDR_22108803_ChIP-Seq_LS180_Human1.12839660
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10985657
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10984911
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10618673
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.09957213
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05501503
73KDM2B_26808549_Chip-Seq_K562_Human1.05357335
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04597759
75* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04363382
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.02819299
77* TCF4_23295773_ChIP-Seq_U87_Human1.02745579
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.02689539
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02599623
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01316780
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00470572
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00221623
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99413078
84AHR_22903824_ChIP-Seq_MCF-7_Human0.98061950
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97964964
86ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97481956
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97437275
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96159089
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95769378
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.95754721
91FUS_26573619_Chip-Seq_HEK293_Human0.95452390
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.94453907
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94425505
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94320563
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93983323
96RUNX2_22187159_ChIP-Seq_PCA_Human0.93787289
97* CTCF_27219007_Chip-Seq_Bcells_Human0.93772733
98SMAD4_21741376_ChIP-Seq_HESCs_Human0.93765156
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92753998
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92729962
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92312860
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92312860
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91388814
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90975121
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90649599
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.89657138
107* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89503132
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89404743
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88835541
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88148778
111* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87064251
112ER_23166858_ChIP-Seq_MCF-7_Human0.86563918
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84889012
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.84607355
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.84287704
116SOX9_26525672_Chip-Seq_HEART_Mouse0.81600433
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81176887
118STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80965321
119CBP_20019798_ChIP-Seq_JUKART_Human0.79970466
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79970466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31766850
2MP0003880_abnormal_central_pattern5.02588330
3MP0003635_abnormal_synaptic_transmissio4.13800097
4MP0004270_analgesia3.83417896
5MP0002063_abnormal_learning/memory/cond3.37317622
6MP0009745_abnormal_behavioral_response3.34781541
7MP0005423_abnormal_somatic_nervous3.28403762
8* MP0002064_seizures3.09288747
9MP0001968_abnormal_touch/_nociception3.00396813
10* MP0009046_muscle_twitch2.84791152
11MP0002734_abnormal_mechanical_nocicepti2.81556954
12MP0002572_abnormal_emotion/affect_behav2.76923367
13MP0001486_abnormal_startle_reflex2.60234987
14MP0002272_abnormal_nervous_system2.51842466
15MP0002822_catalepsy2.42517940
16MP0002735_abnormal_chemical_nociception2.34425507
17MP0002736_abnormal_nociception_after2.31008259
18MP0001440_abnormal_grooming_behavior2.23473234
19MP0002733_abnormal_thermal_nociception2.18705405
20MP0000778_abnormal_nervous_system2.17503089
21MP0001501_abnormal_sleep_pattern2.11346326
22MP0006276_abnormal_autonomic_nervous2.08917102
23MP0001970_abnormal_pain_threshold2.05551360
24MP0002184_abnormal_innervation1.99546496
25* MP0002067_abnormal_sensory_capabilities1.94945272
26MP0003329_amyloid_beta_deposits1.92794350
27MP0004811_abnormal_neuron_physiology1.87568331
28MP0002557_abnormal_social/conspecific_i1.83495790
29MP0009780_abnormal_chondrocyte_physiolo1.83483486
30MP0008569_lethality_at_weaning1.82075621
31MP0004858_abnormal_nervous_system1.76874233
32MP0003121_genomic_imprinting1.72361109
33* MP0004924_abnormal_behavior1.71194289
34* MP0005386_behavior/neurological_phenoty1.71194289
35MP0001984_abnormal_olfaction1.70628890
36MP0002909_abnormal_adrenal_gland1.66378639
37* MP0000955_abnormal_spinal_cord1.61666753
38MP0001529_abnormal_vocalization1.58557902
39MP0008877_abnormal_DNA_methylation1.56703385
40MP0005646_abnormal_pituitary_gland1.54290692
41* MP0002882_abnormal_neuron_morphology1.50251715
42MP0004885_abnormal_endolymph1.47323854
43* MP0002066_abnormal_motor_capabilities/c1.46410835
44MP0005645_abnormal_hypothalamus_physiol1.45680034
45MP0003787_abnormal_imprinting1.43396378
46MP0003122_maternal_imprinting1.43198406
47MP0003879_abnormal_hair_cell1.40949212
48MP0001986_abnormal_taste_sensitivity1.37057690
49MP0001905_abnormal_dopamine_level1.36352900
50MP0003123_paternal_imprinting1.34593732
51MP0000569_abnormal_digit_pigmentation1.25197556
52MP0003633_abnormal_nervous_system1.20950081
53MP0001502_abnormal_circadian_rhythm1.20900854
54* MP0002152_abnormal_brain_morphology1.18495685
55MP0006292_abnormal_olfactory_placode1.17201329
56MP0000751_myopathy1.14565740
57MP0002653_abnormal_ependyma_morphology1.13936236
58MP0003631_nervous_system_phenotype1.07760472
59MP0002102_abnormal_ear_morphology1.07443885
60* MP0004142_abnormal_muscle_tone1.07033184
61MP0001188_hyperpigmentation1.04630121
62MP0004742_abnormal_vestibular_system1.03228925
63MP0004145_abnormal_muscle_electrophysio1.00413214
64MP0002069_abnormal_eating/drinking_beha0.96554447
65MP0008872_abnormal_physiological_respon0.96224128
66* MP0002229_neurodegeneration0.95897125
67MP0004133_heterotaxia0.95261302
68MP0005551_abnormal_eye_electrophysiolog0.93576161
69MP0002837_dystrophic_cardiac_calcinosis0.92037797
70MP0005394_taste/olfaction_phenotype0.91344628
71MP0005499_abnormal_olfactory_system0.91344628
72MP0003634_abnormal_glial_cell0.90477160
73MP0004085_abnormal_heartbeat0.87472527
74MP0002751_abnormal_autonomic_nervous0.87316406
75MP0002752_abnormal_somatic_nervous0.85680523
76MP0003137_abnormal_impulse_conducting0.84721094
77MP0000604_amyloidosis0.83971902
78MP0003632_abnormal_nervous_system0.83224670
79MP0001177_atelectasis0.83061645
80MP0000920_abnormal_myelination0.82818631
81MP0010386_abnormal_urinary_bladder0.82575934
82MP0001963_abnormal_hearing_physiology0.81696980
83MP0008961_abnormal_basal_metabolism0.81336321
84MP0005253_abnormal_eye_physiology0.79978466
85MP0008874_decreased_physiological_sensi0.79232132
86MP0000026_abnormal_inner_ear0.79167084
87MP0006072_abnormal_retinal_apoptosis0.78562071
88MP0003938_abnormal_ear_development0.77833417
89MP0005535_abnormal_body_temperature0.76541627
90MP0003690_abnormal_glial_cell0.75987967
91MP0008789_abnormal_olfactory_epithelium0.74263082
92MP0003890_abnormal_embryonic-extraembry0.72377737
93* MP0000631_abnormal_neuroendocrine_gland0.72051584
94MP0004215_abnormal_myocardial_fiber0.70920806
95MP0004147_increased_porphyrin_level0.70032399
96MP0000013_abnormal_adipose_tissue0.69955714
97MP0003861_abnormal_nervous_system0.69891710
98MP0003283_abnormal_digestive_organ0.68979198
99MP0002638_abnormal_pupillary_reflex0.68711857
100MP0002090_abnormal_vision0.67304102
101MP0003119_abnormal_digestive_system0.67037117
102MP0001299_abnormal_eye_distance/0.65246307
103MP0005409_darkened_coat_color0.65178431
104MP0004130_abnormal_muscle_cell0.64354430
105MP0005195_abnormal_posterior_eye0.63940218
106MP0001664_abnormal_digestion0.62794763
107MP0005623_abnormal_meninges_morphology0.60091255
108MP0001943_abnormal_respiration0.59236826
109MP0001485_abnormal_pinna_reflex0.59015980
110MP0004484_altered_response_of0.58528343
111MP0010769_abnormal_survival0.58482215
112MP0002082_postnatal_lethality0.57270535
113MP0010770_preweaning_lethality0.57270535
114MP0002081_perinatal_lethality0.55986972
115MP0004233_abnormal_muscle_weight0.55655316
116MP0004510_myositis0.55577282
117MP0005187_abnormal_penis_morphology0.55462773
118MP0001348_abnormal_lacrimal_gland0.55217016
119MP0010768_mortality/aging0.54962794
120MP0003075_altered_response_to0.54142066

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.09431880
2Myokymia (HP:0002411)6.67606509
3Focal seizures (HP:0007359)5.53838163
4Visual hallucinations (HP:0002367)5.12137128
5Epileptic encephalopathy (HP:0200134)4.69765959
6Atonic seizures (HP:0010819)4.41898985
7Febrile seizures (HP:0002373)4.23428467
8Progressive cerebellar ataxia (HP:0002073)4.13742288
9Supranuclear gaze palsy (HP:0000605)4.06623781
10Absence seizures (HP:0002121)3.92906647
11Ankle clonus (HP:0011448)3.82794790
12Generalized tonic-clonic seizures (HP:0002069)3.66183359
13Dialeptic seizures (HP:0011146)3.58339496
14Mutism (HP:0002300)3.55164856
15Action tremor (HP:0002345)3.54633511
16Poor eye contact (HP:0000817)3.38374155
17Impaired vibration sensation in the lower limbs (HP:0002166)3.32654451
18Abnormal eating behavior (HP:0100738)3.25364376
19Hyperventilation (HP:0002883)3.20025313
20Urinary bladder sphincter dysfunction (HP:0002839)3.15028647
21Depression (HP:0000716)3.05287790
22Abnormal social behavior (HP:0012433)3.04748935
23Impaired social interactions (HP:0000735)3.04748935
24* Broad-based gait (HP:0002136)3.03914124
25Limb dystonia (HP:0002451)3.00858960
26Papilledema (HP:0001085)3.00754977
27Gaze-evoked nystagmus (HP:0000640)2.96901713
28Spastic gait (HP:0002064)2.94109470
29Progressive inability to walk (HP:0002505)2.93655387
30Polyphagia (HP:0002591)2.92960987
31Amblyopia (HP:0000646)2.92552108
32Neurofibrillary tangles (HP:0002185)2.91719683
33Urinary urgency (HP:0000012)2.90765984
34Dysdiadochokinesis (HP:0002075)2.90418981
35Truncal ataxia (HP:0002078)2.90222077
36Abnormality of the corticospinal tract (HP:0002492)2.89670118
37Excessive salivation (HP:0003781)2.89186389
38Drooling (HP:0002307)2.89186389
39Anxiety (HP:0000739)2.87263986
40Dysmetria (HP:0001310)2.86580829
41Cerebral inclusion bodies (HP:0100314)2.84023100
42Postural instability (HP:0002172)2.73764886
43Abnormality of the labia minora (HP:0012880)2.72376369
44Insidious onset (HP:0003587)2.70580264
45Termporal pattern (HP:0011008)2.70580264
46Genetic anticipation (HP:0003743)2.64573964
47Hemiparesis (HP:0001269)2.64543687
48Torticollis (HP:0000473)2.63143905
49Abnormality of the lower motor neuron (HP:0002366)2.61032374
50Abnormality of binocular vision (HP:0011514)2.59956412
51Diplopia (HP:0000651)2.59956412
52Amyotrophic lateral sclerosis (HP:0007354)2.59551074
53Fetal akinesia sequence (HP:0001989)2.53486299
54Epileptiform EEG discharges (HP:0011182)2.50592221
55Pheochromocytoma (HP:0002666)2.47051450
56Lissencephaly (HP:0001339)2.46015812
57EEG with generalized epileptiform discharges (HP:0011198)2.45278138
58Stereotypic behavior (HP:0000733)2.43107933
59Focal dystonia (HP:0004373)2.42436713
60Scanning speech (HP:0002168)2.42144496
61Lower limb muscle weakness (HP:0007340)2.39717475
62Pachygyria (HP:0001302)2.39638030
63Bradykinesia (HP:0002067)2.39608929
64Akinesia (HP:0002304)2.36203970
65Spastic tetraplegia (HP:0002510)2.35365753
66Hypsarrhythmia (HP:0002521)2.34986393
67Impaired smooth pursuit (HP:0007772)2.33504031
68Inability to walk (HP:0002540)2.31858449
69Absent speech (HP:0001344)2.30200081
70Agitation (HP:0000713)2.28025389
71Megalencephaly (HP:0001355)2.26925625
72Hemiplegia (HP:0002301)2.20844537
73Ventricular fibrillation (HP:0001663)2.20563888
74Craniofacial dystonia (HP:0012179)2.20000622
75Retinal dysplasia (HP:0007973)2.15709294
76Failure to thrive in infancy (HP:0001531)2.14211625
77Cerebral hypomyelination (HP:0006808)2.13527667
78Neuroendocrine neoplasm (HP:0100634)2.12534366
79Insomnia (HP:0100785)2.08932477
80Medial flaring of the eyebrow (HP:0010747)2.08706203
81Impaired vibratory sensation (HP:0002495)2.07374675
82Abnormality of ocular smooth pursuit (HP:0000617)2.06394887
83Hypoplasia of the corpus callosum (HP:0002079)2.03713320
84Generalized myoclonic seizures (HP:0002123)2.02414943
85Inappropriate behavior (HP:0000719)2.01227625
86Abnormality of midbrain morphology (HP:0002418)2.00315283
87Molar tooth sign on MRI (HP:0002419)2.00315283
88Gait imbalance (HP:0002141)1.98989373
89Specific learning disability (HP:0001328)1.98934599
90Clonus (HP:0002169)1.98794501
91Aplasia/Hypoplasia of the brainstem (HP:0007362)1.97548539
92Hypoplasia of the brainstem (HP:0002365)1.97548539
93Nephronophthisis (HP:0000090)1.97335885
94Type II lissencephaly (HP:0007260)1.95984794
95Poor suck (HP:0002033)1.95238140
96Morphological abnormality of the pyramidal tract (HP:0002062)1.94702347
97Cortical dysplasia (HP:0002539)1.93133228
98Peripheral hypomyelination (HP:0007182)1.92309617
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91149569
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.91149569
101Neuronal loss in central nervous system (HP:0002529)1.91105571
102Pointed chin (HP:0000307)1.90994237
103Status epilepticus (HP:0002133)1.90786232
104Abnormality of salivation (HP:0100755)1.90600889
105Congenital primary aphakia (HP:0007707)1.90427666
106Spastic tetraparesis (HP:0001285)1.88991437
107Incomplete penetrance (HP:0003829)1.87917477
108Sleep apnea (HP:0010535)1.87729989
109Protruding tongue (HP:0010808)1.86276951
110Obstructive sleep apnea (HP:0002870)1.85567346
111Hypoventilation (HP:0002791)1.84918345
112Esotropia (HP:0000565)1.84522516
113Abnormal EKG (HP:0003115)1.84146707
114Blue irides (HP:0000635)1.83793324
115Apathy (HP:0000741)1.83738770
116Pancreatic cysts (HP:0001737)1.81955985
117Vaginal atresia (HP:0000148)1.81616491
118Pancreatic fibrosis (HP:0100732)1.81516410
119Lower limb amyotrophy (HP:0007210)1.81215653
120Nephrogenic diabetes insipidus (HP:0009806)1.80663471
121Optic nerve hypoplasia (HP:0000609)1.80591422
122True hermaphroditism (HP:0010459)1.80434123
123Genital tract atresia (HP:0001827)1.79005982
124Delusions (HP:0000746)1.77839431
125Oligodactyly (hands) (HP:0001180)1.77659091
126Dysmetric saccades (HP:0000641)1.76599566
127* Intention tremor (HP:0002080)1.76443922
128Muscular hypotonia of the trunk (HP:0008936)1.72053183
129Intellectual disability, severe (HP:0010864)1.70690134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.64393489
2NTRK33.97144785
3MAP3K93.83369364
4EPHA43.74419507
5MAP3K43.05375070
6MINK12.82386400
7MAP2K72.61937346
8NTRK22.42571349
9DAPK22.36201686
10PAK62.33419052
11CASK2.03481092
12MAP2K41.85000951
13MAP3K121.84143052
14KSR21.82149253
15KSR11.79863583
16NTRK11.70731688
17MAPK131.68283121
18CDK51.60674530
19CAMKK11.57691939
20TNIK1.55984605
21SIK21.54412686
22PHKG11.49278099
23PHKG21.49278099
24PRKD31.46920437
25CDK191.45466110
26PLK21.44595702
27PNCK1.39992850
28UHMK11.37514738
29DAPK11.34943799
30GRK51.34354902
31PRPF4B1.30266336
32RIPK41.27598653
33TYRO31.21174650
34LATS21.20470689
35PRKCG1.19218512
36FES1.05340282
37CDK181.02032991
38STK381.01519752
39MAP4K21.00807356
40WNK40.99574457
41CDK150.99468584
42CDK140.96728201
43ARAF0.96159184
44FRK0.95584323
45CAMK2A0.94714135
46CSNK1G20.93581061
47MAP3K20.91993381
48SGK4940.90931266
49SGK2230.90931266
50STK110.87624135
51CDK11A0.87306662
52OXSR10.86235913
53PAK30.86215621
54DYRK1A0.83879851
55ADRBK20.83374313
56MARK20.82814970
57CAMK10.80668140
58CAMKK20.80206817
59RET0.80140232
60TRIM280.78521476
61CSNK1A1L0.77644093
62TAOK10.76830441
63MAP3K130.74944857
64CAMK2B0.72997427
65DYRK20.71570288
66PRKCH0.70167555
67LMTK20.67911404
68CSNK1G10.65126876
69PRKCZ0.63594581
70SGK20.63324250
71SGK10.62120063
72BMPR1B0.62042683
73ALK0.60644417
74PKN10.60441223
75INSRR0.60276500
76ERBB30.60107643
77CAMK1D0.59047248
78RAF10.54833116
79EPHA30.53983440
80BCR0.53519266
81PTK2B0.53087563
82CCNB10.52914842
83PINK10.52489831
84LIMK10.52412256
85EPHB20.51955684
86SGK30.51527678
87GRK10.50900313
88WNK30.50495180
89PRKCE0.50479108
90SCYL20.49744112
91FYN0.48965284
92NME10.48008757
93BMPR20.47944006
94CAMK1G0.46534157
95CSNK1E0.46292500
96RPS6KA30.45908587
97PDK10.45422501
98STK390.45095677
99CSNK1D0.44691233
100CSNK1G30.44412057
101PRKACA0.44306896
102FGR0.43556637
103PDPK10.42745576
104RPS6KA20.42014253
105DYRK1B0.41255614
106ERBB20.40708923
107CAMK2D0.40540216
108MAPK100.40442467
109MAP3K60.39638014
110MAPK120.39143951
111CDC42BPA0.39118806
112CAMK2G0.38734455
113PRKG10.37814503
114CSNK1A10.37804196
115PRKAA10.37578881
116ROCK20.37496539
117FGFR20.37283825
118SIK30.36766438
119MAP2K60.35997433
120CAMK40.35544358
121NEK60.35387075
122TNK20.35203144
123MAPK80.33159354
124PRKCA0.32502592
125DYRK30.31592216
126ADRBK10.29727569
127GSK3B0.28998393
128BRAF0.28590568
129MAP3K110.28480519

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79652925
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48367856
3GABAergic synapse_Homo sapiens_hsa047272.76086014
4Olfactory transduction_Homo sapiens_hsa047402.72816124
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68998986
6Circadian entrainment_Homo sapiens_hsa047132.64949192
7Glutamatergic synapse_Homo sapiens_hsa047242.56153431
8Long-term potentiation_Homo sapiens_hsa047202.51333661
9Morphine addiction_Homo sapiens_hsa050322.51019923
10Amphetamine addiction_Homo sapiens_hsa050312.31539704
11Dopaminergic synapse_Homo sapiens_hsa047282.23277575
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20500876
13Salivary secretion_Homo sapiens_hsa049702.04030502
14Cholinergic synapse_Homo sapiens_hsa047251.95135501
15Insulin secretion_Homo sapiens_hsa049111.87971599
16Gastric acid secretion_Homo sapiens_hsa049711.80553946
17Taste transduction_Homo sapiens_hsa047421.77619903
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70318211
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70291759
20Serotonergic synapse_Homo sapiens_hsa047261.70131718
21Long-term depression_Homo sapiens_hsa047301.69254358
22Cocaine addiction_Homo sapiens_hsa050301.64451320
23Renin secretion_Homo sapiens_hsa049241.64160702
24Oxytocin signaling pathway_Homo sapiens_hsa049211.62962788
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61055750
26Collecting duct acid secretion_Homo sapiens_hsa049661.57860806
27Calcium signaling pathway_Homo sapiens_hsa040201.47660529
28Axon guidance_Homo sapiens_hsa043601.44283357
29GnRH signaling pathway_Homo sapiens_hsa049121.41526817
30Gap junction_Homo sapiens_hsa045401.39907353
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34408988
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25248549
33cAMP signaling pathway_Homo sapiens_hsa040241.18600356
34Type II diabetes mellitus_Homo sapiens_hsa049301.16483767
35Cardiac muscle contraction_Homo sapiens_hsa042601.15011042
36Estrogen signaling pathway_Homo sapiens_hsa049151.11197018
37ErbB signaling pathway_Homo sapiens_hsa040121.09540243
38Glioma_Homo sapiens_hsa052141.08761949
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08519782
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04714273
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03793949
42Vibrio cholerae infection_Homo sapiens_hsa051101.00735367
43Melanogenesis_Homo sapiens_hsa049161.00088088
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97033499
45Phototransduction_Homo sapiens_hsa047440.96920710
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94881631
47Oocyte meiosis_Homo sapiens_hsa041140.90415774
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.87094750
49Butanoate metabolism_Homo sapiens_hsa006500.86888769
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82206552
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.81086035
52Dorso-ventral axis formation_Homo sapiens_hsa043200.79125858
53Dilated cardiomyopathy_Homo sapiens_hsa054140.74106558
54Pancreatic secretion_Homo sapiens_hsa049720.72149893
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71643191
56MAPK signaling pathway_Homo sapiens_hsa040100.71441984
57Choline metabolism in cancer_Homo sapiens_hsa052310.70071740
58Ether lipid metabolism_Homo sapiens_hsa005650.70014974
59Vitamin B6 metabolism_Homo sapiens_hsa007500.68172514
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66394977
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66021813
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.65950037
63Huntingtons disease_Homo sapiens_hsa050160.64788661
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63810037
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63682857
66Thyroid hormone synthesis_Homo sapiens_hsa049180.62949696
67VEGF signaling pathway_Homo sapiens_hsa043700.61302667
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60627657
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60238124
70Ras signaling pathway_Homo sapiens_hsa040140.60131497
71Alcoholism_Homo sapiens_hsa050340.59612604
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.57795467
73Endometrial cancer_Homo sapiens_hsa052130.57166436
74Renal cell carcinoma_Homo sapiens_hsa052110.56099627
75Alzheimers disease_Homo sapiens_hsa050100.55902261
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54471575
77Endocytosis_Homo sapiens_hsa041440.54170853
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53656882
79Rap1 signaling pathway_Homo sapiens_hsa040150.51648346
80Regulation of autophagy_Homo sapiens_hsa041400.50906902
81Glucagon signaling pathway_Homo sapiens_hsa049220.49767099
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49698091
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49178737
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48559016
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48326913
86mTOR signaling pathway_Homo sapiens_hsa041500.46717234
87Linoleic acid metabolism_Homo sapiens_hsa005910.46125390
88Steroid biosynthesis_Homo sapiens_hsa001000.45957064
89Wnt signaling pathway_Homo sapiens_hsa043100.45753277
90Hippo signaling pathway_Homo sapiens_hsa043900.44881193
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44398635
92Type I diabetes mellitus_Homo sapiens_hsa049400.44327237
93Nitrogen metabolism_Homo sapiens_hsa009100.44175281
94Hedgehog signaling pathway_Homo sapiens_hsa043400.43475549
95Prion diseases_Homo sapiens_hsa050200.42980964
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42933730
97Insulin signaling pathway_Homo sapiens_hsa049100.42836075
98Inositol phosphate metabolism_Homo sapiens_hsa005620.41218362
99Oxidative phosphorylation_Homo sapiens_hsa001900.40081712
100Circadian rhythm_Homo sapiens_hsa047100.39659133
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39225117
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39199750
103Colorectal cancer_Homo sapiens_hsa052100.38781648
104Non-small cell lung cancer_Homo sapiens_hsa052230.38199968
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37454211
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37218394
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36787776
108Bile secretion_Homo sapiens_hsa049760.36607219
109Parkinsons disease_Homo sapiens_hsa050120.36011499
110beta-Alanine metabolism_Homo sapiens_hsa004100.35302891
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35253390
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34386654
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34264049
114Ovarian steroidogenesis_Homo sapiens_hsa049130.33642151
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31697660
116Chemokine signaling pathway_Homo sapiens_hsa040620.31416804
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30864541
118Tight junction_Homo sapiens_hsa045300.24290900
119Basal cell carcinoma_Homo sapiens_hsa052170.22300979

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