ATF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.51187175
2protein localization to kinetochore (GO:0034501)4.25038201
3protein localization to chromosome, centromeric region (GO:0071459)4.01307779
4metaphase plate congression (GO:0051310)3.89534651
5mitotic nuclear envelope disassembly (GO:0007077)3.85655519
6regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.83338030
7nuclear pore organization (GO:0006999)3.82733365
8regulation of spindle organization (GO:0090224)3.79017215
9DNA replication checkpoint (GO:0000076)3.78816129
10nuclear pore complex assembly (GO:0051292)3.78167634
11proteasome assembly (GO:0043248)3.75676264
12attachment of spindle microtubules to kinetochore (GO:0008608)3.64969531
13meiotic chromosome segregation (GO:0045132)3.59137901
14maturation of 5.8S rRNA (GO:0000460)3.58932824
15purine nucleobase biosynthetic process (GO:0009113)3.57547935
16nuclear envelope disassembly (GO:0051081)3.54940029
17membrane disassembly (GO:0030397)3.54940029
18mitotic chromosome condensation (GO:0007076)3.53210177
19mitotic sister chromatid cohesion (GO:0007064)3.52340828
20pteridine-containing compound biosynthetic process (GO:0042559)3.50942852
21kinetochore organization (GO:0051383)3.50367507
22nucleobase biosynthetic process (GO:0046112)3.48325865
23formation of translation preinitiation complex (GO:0001731)3.47995005
24CENP-A containing nucleosome assembly (GO:0034080)3.46735292
25DNA replication initiation (GO:0006270)3.45210504
26chromatin remodeling at centromere (GO:0031055)3.41037177
27mitotic sister chromatid segregation (GO:0000070)3.39301110
28regulation of centriole replication (GO:0046599)3.38935186
29establishment of chromosome localization (GO:0051303)3.38800680
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36902155
31ribosome assembly (GO:0042255)3.32936868
32DNA strand elongation involved in DNA replication (GO:0006271)3.31228548
33DNA deamination (GO:0045006)3.31047308
34rRNA methylation (GO:0031167)3.28904903
35DNA replication-independent nucleosome assembly (GO:0006336)3.27365074
36DNA replication-independent nucleosome organization (GO:0034724)3.27365074
37ribosome biogenesis (GO:0042254)3.24930406
38regulation of translational termination (GO:0006449)3.20290326
39telomere maintenance via semi-conservative replication (GO:0032201)3.16293866
40DNA strand elongation (GO:0022616)3.15161161
41telomere maintenance via recombination (GO:0000722)3.12343125
42DNA unwinding involved in DNA replication (GO:0006268)3.11335765
43sister chromatid segregation (GO:0000819)3.11178732
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10748068
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10049634
46positive regulation of chromosome segregation (GO:0051984)3.09461464
47regulation of mitotic spindle organization (GO:0060236)3.08258614
48regulation of translational fidelity (GO:0006450)3.07903288
49ribosomal large subunit biogenesis (GO:0042273)3.07622176
50folic acid-containing compound biosynthetic process (GO:0009396)3.07558403
51maturation of SSU-rRNA (GO:0030490)3.06231969
52kinetochore assembly (GO:0051382)3.05831181
53protein K6-linked ubiquitination (GO:0085020)3.05824209
54pseudouridine synthesis (GO:0001522)3.05184445
55pore complex assembly (GO:0046931)3.01722037
56mitotic recombination (GO:0006312)3.00326384
57histone mRNA metabolic process (GO:0008334)3.00024622
58cellular protein complex localization (GO:0034629)2.99500261
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97351875
60protein localization to chromosome (GO:0034502)2.97165774
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96785686
62IMP biosynthetic process (GO:0006188)2.96779862
63histone exchange (GO:0043486)2.95595623
64IMP metabolic process (GO:0046040)2.89185897
65negative regulation of ligase activity (GO:0051352)2.86765397
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86765397
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86142251
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86142251
69positive regulation of mitotic sister chromatid separation (GO:1901970)2.86142251
70regulation of chromosome segregation (GO:0051983)2.86010722
71tRNA aminoacylation (GO:0043039)2.85026744
72amino acid activation (GO:0043038)2.85026744
73nuclear envelope organization (GO:0006998)2.84809724
74ribosomal small subunit assembly (GO:0000028)2.84519611
75tRNA aminoacylation for protein translation (GO:0006418)2.83805198
76spindle checkpoint (GO:0031577)2.83561360
77DNA replication-dependent nucleosome assembly (GO:0006335)2.80863380
78DNA replication-dependent nucleosome organization (GO:0034723)2.80863380
79regulation of nuclear cell cycle DNA replication (GO:0033262)2.78971744
80regulation of double-strand break repair via homologous recombination (GO:0010569)2.78730136
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76012043
82folic acid metabolic process (GO:0046655)2.74344879
83ribonucleoprotein complex biogenesis (GO:0022613)2.74235790
84chromosome segregation (GO:0007059)2.73125800
85regulation of mitochondrial translation (GO:0070129)2.72871759
86regulation of mitotic metaphase/anaphase transition (GO:0030071)2.71886883
87nucleobase-containing small molecule interconversion (GO:0015949)2.71713715
88regulation of RNA export from nucleus (GO:0046831)2.67454433
89histone mRNA catabolic process (GO:0071044)2.67354630
90telomere maintenance via telomere lengthening (GO:0010833)2.67114384
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66983832
92histone-serine phosphorylation (GO:0035404)2.66853241
93negative regulation of chromosome segregation (GO:0051985)2.66622478
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64977120
95chromatin assembly or disassembly (GO:0006333)2.64937926
96regulation of centrosome duplication (GO:0010824)2.64932090
97cell cycle G1/S phase transition (GO:0044843)2.64678688
98G1/S transition of mitotic cell cycle (GO:0000082)2.64678688
99negative regulation of mitotic sister chromatid separation (GO:2000816)2.62796120
100negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62796120
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62796120
102negative regulation of sister chromatid segregation (GO:0033046)2.62796120
103regulation of translational elongation (GO:0006448)2.62727888
104spindle assembly checkpoint (GO:0071173)2.61405453
105ribonucleoprotein complex disassembly (GO:0032988)2.59761806
106AMP metabolic process (GO:0046033)2.58939316
1073-UTR-mediated mRNA stabilization (GO:0070935)2.58808487
108rRNA processing (GO:0006364)2.57615470
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57540971
110mitotic spindle assembly checkpoint (GO:0007094)2.56820553
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.56718370
112regulation of sister chromatid cohesion (GO:0007063)2.56655371
113mitotic spindle checkpoint (GO:0071174)2.55739908
114protein complex localization (GO:0031503)2.54338059
115signal transduction involved in DNA damage checkpoint (GO:0072422)2.53946656
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.53946656
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53318140
118signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53318140
119signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53318140
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52288402
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52288402
122rRNA metabolic process (GO:0016072)2.52070427
123regulation of mitotic sister chromatid segregation (GO:0033047)2.51927552
124regulation of sister chromatid segregation (GO:0033045)2.51927552
125regulation of mitotic sister chromatid separation (GO:0010965)2.51927552
126regulation of centrosome cycle (GO:0046605)2.51208437
127positive regulation of ligase activity (GO:0051351)2.50781153
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50539391
129ATP-dependent chromatin remodeling (GO:0043044)2.49969895
130negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.49736605
131monoubiquitinated protein deubiquitination (GO:0035520)2.48408567
132translational initiation (GO:0006413)2.45583445
133DNA geometric change (GO:0032392)2.43701629
134inner cell mass cell proliferation (GO:0001833)2.43666076
135DNA duplex unwinding (GO:0032508)2.43125681
136rRNA modification (GO:0000154)2.42488055
137mitotic G2/M transition checkpoint (GO:0044818)2.39857183
138telomere maintenance (GO:0000723)2.37528035
139telomere organization (GO:0032200)2.36066847
140mismatch repair (GO:0006298)2.35667862
141regulation of translation in response to stress (GO:0043555)2.33515053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79056652
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.51139266
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.54644126
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43093984
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26766905
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.94866877
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91084922
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34538010
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32921378
10AR_21909140_ChIP-Seq_LNCAP_Human2.23889325
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20937290
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.18483763
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17958248
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12679485
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.10327601
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09376099
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03928692
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.02309231
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.01891322
20MYC_22102868_ChIP-Seq_BL_Human2.01305397
21* VDR_23849224_ChIP-Seq_CD4+_Human1.97491472
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92407918
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90548904
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78999122
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78851326
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78448312
27* XRN2_22483619_ChIP-Seq_HELA_Human1.78362917
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75456982
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75150018
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70114724
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69076326
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67106929
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66851157
34FOXP3_21729870_ChIP-Seq_TREG_Human1.66663227
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62539195
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62198818
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.61481237
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59693827
39DCP1A_22483619_ChIP-Seq_HELA_Human1.58988379
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.58822739
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56692600
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55647083
43GABP_19822575_ChIP-Seq_HepG2_Human1.54739198
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51389215
45ELK1_19687146_ChIP-ChIP_HELA_Human1.49050579
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44895065
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44455685
48KDM5A_27292631_Chip-Seq_BREAST_Human1.43852089
49CIITA_25753668_ChIP-Seq_RAJI_Human1.43749844
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43592602
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41318177
52TTF2_22483619_ChIP-Seq_HELA_Human1.38963656
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38953296
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35919236
55* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35451394
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33899112
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32326969
58* SPI1_23547873_ChIP-Seq_NB4_Human1.28448591
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26400516
60ZNF263_19887448_ChIP-Seq_K562_Human1.25849040
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25817236
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22056971
63* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21926197
64* TFEB_21752829_ChIP-Seq_HELA_Human1.21309087
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20664963
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19887188
67MYC_18940864_ChIP-ChIP_HL60_Human1.17385138
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14795138
69VDR_21846776_ChIP-Seq_THP-1_Human1.12848708
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.11817095
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10536484
72* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10527117
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10472399
74MYB_26560356_Chip-Seq_TH1_Human1.09477697
75* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08767920
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07778262
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07300604
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05818034
79CHD1_26751641_Chip-Seq_LNCaP_Human1.05233049
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05148470
81MYB_26560356_Chip-Seq_TH2_Human1.04731481
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02624993
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.02289006
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01731568
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00212715
86SCL_19346495_ChIP-Seq_HPC-7_Human0.99631870
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98915312
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98830341
89ELF5_23300383_ChIP-Seq_T47D_Human0.98338804
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97884334
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97495713
92EWS_26573619_Chip-Seq_HEK293_Human0.96364310
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96247165
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.95303990
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95161383
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93794978
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.93036268
98IRF8_22096565_ChIP-ChIP_GC-B_Human0.92475314
99MAF_26560356_Chip-Seq_TH1_Human0.92354235
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91417695
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90476146
102THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90233606
103IRF8_21731497_ChIP-ChIP_J774_Mouse0.89535500
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89082580
105RUNX1_22412390_ChIP-Seq_EML_Mouse0.88806433
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88792272
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.87168476
108* UTX_26944678_Chip-Seq_JUKART_Human0.86613816
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86389684
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84593736
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84454869
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83228862
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82846885
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82815160
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82561694
116GATA1_22025678_ChIP-Seq_K562_Human0.82136279
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81429405
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.81188192
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80242076
120FUS_26573619_Chip-Seq_HEK293_Human0.80130059
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79895612
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79067862
123TCF7_22412390_ChIP-Seq_EML_Mouse0.78508403
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.77814685
125RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77718571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003693_abnormal_embryo_hatching4.12468331
2MP0003111_abnormal_nucleus_morphology3.36732577
3MP0010094_abnormal_chromosome_stability3.36199267
4* MP0004957_abnormal_blastocyst_morpholog3.27590748
5MP0003077_abnormal_cell_cycle3.09296783
6MP0008057_abnormal_DNA_replication2.94084407
7MP0002396_abnormal_hematopoietic_system2.69777458
8MP0009697_abnormal_copulation2.63097244
9MP0008007_abnormal_cellular_replicative2.34326239
10MP0008058_abnormal_DNA_repair2.31326515
11MP0010234_abnormal_vibrissa_follicle2.16202643
12MP0010352_gastrointestinal_tract_polyps2.14848610
13MP0002009_preneoplasia2.13018711
14MP0004233_abnormal_muscle_weight2.07650628
15MP0010307_abnormal_tumor_latency1.97735593
16MP0004808_abnormal_hematopoietic_stem1.97014687
17MP0001545_abnormal_hematopoietic_system1.85235158
18MP0005397_hematopoietic_system_phenotyp1.85235158
19MP0000350_abnormal_cell_proliferation1.83051263
20MP0001730_embryonic_growth_arrest1.70970001
21MP0002163_abnormal_gland_morphology1.64905073
22MP0000490_abnormal_crypts_of1.64373920
23MP0006036_abnormal_mitochondrial_physio1.63376891
24MP0003763_abnormal_thymus_physiology1.57258272
25MP0008932_abnormal_embryonic_tissue1.53605543
26MP0001672_abnormal_embryogenesis/_devel1.51206104
27MP0005380_embryogenesis_phenotype1.51206104
28MP0003718_maternal_effect1.48454657
29MP0009333_abnormal_splenocyte_physiolog1.47086062
30MP0003950_abnormal_plasma_membrane1.46718649
31MP0003786_premature_aging1.46083093
32MP0003984_embryonic_growth_retardation1.43295637
33MP0002796_impaired_skin_barrier1.42321821
34MP0005451_abnormal_body_composition1.42201698
35MP0009278_abnormal_bone_marrow1.40944761
36MP0002088_abnormal_embryonic_growth/wei1.40380770
37MP0005076_abnormal_cell_differentiation1.37832651
38MP0002019_abnormal_tumor_incidence1.37056497
39MP0001697_abnormal_embryo_size1.35358182
40MP0006035_abnormal_mitochondrial_morpho1.34019259
41MP0002398_abnormal_bone_marrow1.33872735
42MP0002138_abnormal_hepatobiliary_system1.29694928
43MP0008877_abnormal_DNA_methylation1.27751943
44MP0004185_abnormal_adipocyte_glucose1.27740167
45* MP0002086_abnormal_extraembryonic_tissu1.24752555
46MP0005379_endocrine/exocrine_gland_phen1.24289624
47MP0003567_abnormal_fetal_cardiomyocyte1.22861518
48MP0002722_abnormal_immune_system1.21467286
49MP0000703_abnormal_thymus_morphology1.21200242
50MP0000689_abnormal_spleen_morphology1.19534482
51* MP0000313_abnormal_cell_death1.19490951
52* MP0002080_prenatal_lethality1.18585082
53MP0002877_abnormal_melanocyte_morpholog1.18313251
54MP0003123_paternal_imprinting1.17971463
55MP0000858_altered_metastatic_potential1.12885873
56MP0000358_abnormal_cell_content/1.11502718
57MP0001800_abnormal_humoral_immune1.09742119
58MP0003436_decreased_susceptibility_to1.09213971
59MP0001835_abnormal_antigen_presentation1.08447827
60* MP0002085_abnormal_embryonic_tissue1.06228208
61MP0004197_abnormal_fetal_growth/weight/1.04511305
62MP0003705_abnormal_hypodermis_morpholog1.03781688
63MP0002429_abnormal_blood_cell1.02888403
64MP0001853_heart_inflammation1.02727331
65MP0000427_abnormal_hair_cycle1.02220712
66MP0005671_abnormal_response_to1.02018973
67MP0005023_abnormal_wound_healing1.02013690
68MP0000716_abnormal_immune_system1.01909542
69MP0010678_abnormal_skin_adnexa1.01634383
70MP0003566_abnormal_cell_adhesion1.01360561
71MP0002405_respiratory_system_inflammati1.00734788
72MP0000685_abnormal_immune_system1.00446932
73MP0001727_abnormal_embryo_implantation0.99452193
74MP0002452_abnormal_antigen_presenting0.98873809
75MP0005501_abnormal_skin_physiology0.98221595
76MP0006054_spinal_hemorrhage0.98195685
77* MP0002084_abnormal_developmental_patter0.97866959
78MP0002166_altered_tumor_susceptibility0.97306670
79MP0002210_abnormal_sex_determination0.97268700
80MP0002006_tumorigenesis0.96868646
81MP0003448_altered_tumor_morphology0.93867290
82MP0002420_abnormal_adaptive_immunity0.93623648
83MP0001819_abnormal_immune_cell0.92479828
84MP0002060_abnormal_skin_morphology0.91444914
85MP0002132_abnormal_respiratory_system0.91180740
86MP0005220_abnormal_exocrine_pancreas0.90800324
87MP0001293_anophthalmia0.90752121
88MP0000627_abnormal_mammary_gland0.90523750
89MP0003646_muscle_fatigue0.90277864
90MP0003806_abnormal_nucleotide_metabolis0.89849227
91MP0001119_abnormal_female_reproductive0.88898063
92MP0002723_abnormal_immune_serum0.87423765
93MP0003828_pulmonary_edema0.87190210
94MP0005266_abnormal_metabolism0.85993859
95MP0002269_muscular_atrophy0.85242643
96MP0003656_abnormal_erythrocyte_physiolo0.84136276
97MP0003221_abnormal_cardiomyocyte_apopto0.83814215
98MP0001216_abnormal_epidermal_layer0.82686648
99MP0001881_abnormal_mammary_gland0.82154614
100MP0003186_abnormal_redox_activity0.81872891
101MP0001661_extended_life_span0.80884363
102MP0001145_abnormal_male_reproductive0.80110744
103MP0003303_peritoneal_inflammation0.80086322
104MP0001929_abnormal_gametogenesis0.79292250
105MP0005083_abnormal_biliary_tract0.78335858
106MP0000750_abnormal_muscle_regeneration0.77961388
107MP0001243_abnormal_dermal_layer0.76403115
108MP0005000_abnormal_immune_tolerance0.76329504
109MP0009785_altered_susceptibility_to0.76181215
110MP0005464_abnormal_platelet_physiology0.75536732
111MP0005621_abnormal_cell_physiology0.75366121
112MP0000653_abnormal_sex_gland0.74146726
113MP0005025_abnormal_response_to0.74042076
114MP0009672_abnormal_birth_weight0.73960931
115MP0010155_abnormal_intestine_physiology0.73161672
116MP0000733_abnormal_muscle_development0.73120720
117MP0004264_abnormal_extraembryonic_tissu0.72997257
118MP0006292_abnormal_olfactory_placode0.72460141
119MP0002693_abnormal_pancreas_physiology0.72285303
120MP0000013_abnormal_adipose_tissue0.71026630
121MP0002419_abnormal_innate_immunity0.70792932
122MP0001915_intracranial_hemorrhage0.68570241
123MP0001764_abnormal_homeostasis0.67790853
124MP0000372_irregular_coat_pigmentation0.65839029
125MP0005084_abnormal_gallbladder_morpholo0.65402780
126MP0005384_cellular_phenotype0.65151009
127MP0005395_other_phenotype0.64016724
128MP0001845_abnormal_inflammatory_respons0.63165878
129MP0003941_abnormal_skin_development0.63032878
130MP0003890_abnormal_embryonic-extraembry0.62750249
131MP0001790_abnormal_immune_system0.62508451
132MP0005387_immune_system_phenotype0.62508451
133MP0000598_abnormal_liver_morphology0.62248380
134MP0004147_increased_porphyrin_level0.61795066
135MP0005075_abnormal_melanosome_morpholog0.61779875
136MP0004947_skin_inflammation0.61565684
137MP0001873_stomach_inflammation0.61162129
138MP0008873_increased_physiological_sensi0.59991396
139MP0009703_decreased_birth_body0.59915540
140MP0005319_abnormal_enzyme/_coenzyme0.59052670

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.69809691
2Sensory axonal neuropathy (HP:0003390)3.75176153
3Breast hypoplasia (HP:0003187)3.68160434
4Reduced antithrombin III activity (HP:0001976)3.59072749
5Chromsome breakage (HP:0040012)3.45631157
6Nemaline bodies (HP:0003798)3.21245761
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.10000121
8Abnormality of alanine metabolism (HP:0010916)3.10000121
9Hyperalaninemia (HP:0003348)3.10000121
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.09446714
11Abnormality of the anterior horn cell (HP:0006802)3.01619636
12Degeneration of anterior horn cells (HP:0002398)3.01619636
13Abnormality of chromosome stability (HP:0003220)2.96810324
14B lymphocytopenia (HP:0010976)2.94935638
15Muscle fiber inclusion bodies (HP:0100299)2.84962680
16Myelodysplasia (HP:0002863)2.82654994
17Impulsivity (HP:0100710)2.81260033
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.80036530
19Patellar aplasia (HP:0006443)2.76480470
20Abnormality of the preputium (HP:0100587)2.75147146
21Meckel diverticulum (HP:0002245)2.69295669
22Aplastic anemia (HP:0001915)2.68185846
23Aplasia/Hypoplasia of the patella (HP:0006498)2.65818486
24Acute myeloid leukemia (HP:0004808)2.60421357
25Curly hair (HP:0002212)2.59648148
26Microvesicular hepatic steatosis (HP:0001414)2.58297309
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.57620366
28Carpal bone hypoplasia (HP:0001498)2.56026515
29Reticulocytopenia (HP:0001896)2.55397188
30Abnormality of the ileum (HP:0001549)2.50808066
31Abnormality of methionine metabolism (HP:0010901)2.46125753
32Selective tooth agenesis (HP:0001592)2.45706354
33Oral leukoplakia (HP:0002745)2.44614982
34Abnormality of the fingertips (HP:0001211)2.43784651
35Nephroblastoma (Wilms tumor) (HP:0002667)2.41183636
36Increased serum pyruvate (HP:0003542)2.37678181
37Prominent nose (HP:0000448)2.35798803
38Type I transferrin isoform profile (HP:0003642)2.34566767
39Cutaneous melanoma (HP:0012056)2.33310114
40Gonadotropin excess (HP:0000837)2.31288044
41Papillary thyroid carcinoma (HP:0002895)2.30464929
42Ectopic kidney (HP:0000086)2.27041039
43Thrombocytosis (HP:0001894)2.26634555
44Exercise-induced muscle cramps (HP:0003710)2.26213332
45Absent thumb (HP:0009777)2.25556635
46Agnosia (HP:0010524)2.24925296
47Colon cancer (HP:0003003)2.23635334
48Embryonal renal neoplasm (HP:0011794)2.23150878
49Abnormality of B cell number (HP:0010975)2.22590985
50Abnormality of glycolysis (HP:0004366)2.20835561
51Bone marrow hypocellularity (HP:0005528)2.19106290
52Duodenal stenosis (HP:0100867)2.17486200
53Small intestinal stenosis (HP:0012848)2.17486200
54Abnormality of cells of the erythroid lineage (HP:0012130)2.14896554
55Abnormal number of erythroid precursors (HP:0012131)2.12696545
56Microretrognathia (HP:0000308)2.11783287
57Paralysis (HP:0003470)2.11436396
58Abnormal lung lobation (HP:0002101)2.10493253
59Abnormal protein glycosylation (HP:0012346)2.06856115
60Abnormal glycosylation (HP:0012345)2.06856115
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06856115
62Abnormal protein N-linked glycosylation (HP:0012347)2.06856115
63Blepharitis (HP:0000498)2.06636505
64Volvulus (HP:0002580)2.06129072
65Facial hemangioma (HP:0000329)2.05210926
66Rough bone trabeculation (HP:0100670)2.04904077
67Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03929562
68Clubbing of toes (HP:0100760)2.03712732
69Pancreatic islet-cell hyperplasia (HP:0004510)2.03525657
70Cleft eyelid (HP:0000625)2.03491933
71Entropion (HP:0000621)2.03252382
72Thyroid carcinoma (HP:0002890)2.02275194
73Slender long bone (HP:0003100)2.00646436
74Long eyelashes (HP:0000527)2.00616086
75Rhabdomyosarcoma (HP:0002859)2.00218995
76Lymphoma (HP:0002665)1.99935104
77Medulloblastoma (HP:0002885)1.99750065
78Overlapping toe (HP:0001845)1.99077791
79Abnormal spermatogenesis (HP:0008669)1.98753489
80Abnormality of the umbilical cord (HP:0010881)1.98288764
81Abnormal umbilical cord blood vessels (HP:0011403)1.97738696
82Single umbilical artery (HP:0001195)1.97738696
83Abnormality of the fetal cardiovascular system (HP:0010948)1.97738696
84IgM deficiency (HP:0002850)1.97658957
85Neoplasm of the pancreas (HP:0002894)1.97497091
86Pelvic girdle muscle weakness (HP:0003749)1.97106658
87Sloping forehead (HP:0000340)1.95757923
88Microglossia (HP:0000171)1.94474332
89Muscle fiber atrophy (HP:0100295)1.93147138
90Pancytopenia (HP:0001876)1.92727670
91Absent radius (HP:0003974)1.91769370
92Capillary hemangiomas (HP:0005306)1.91447105
93Pustule (HP:0200039)1.91385721
94Multiple enchondromatosis (HP:0005701)1.90931783
95Abnormality of T cell physiology (HP:0011840)1.89235961
96Unilateral renal agenesis (HP:0000122)1.88587569
97Ankle contracture (HP:0006466)1.87884965
98Abnormal foot bone ossification (HP:0010675)1.87216475
99Deep philtrum (HP:0002002)1.87098545
100Increased CSF lactate (HP:0002490)1.86873951
101Abnormality of T cells (HP:0002843)1.86475955
102Combined immunodeficiency (HP:0005387)1.85841416
103Increased serum lactate (HP:0002151)1.84343377
104Ependymoma (HP:0002888)1.83439392
105Biliary tract neoplasm (HP:0100574)1.83142369
106Recurrent viral infections (HP:0004429)1.82768090
107Abnormality of the pancreatic islet cells (HP:0006476)1.82703863
108Abnormality of endocrine pancreas physiology (HP:0012093)1.82703863
109Proximal placement of thumb (HP:0009623)1.80541346
110Recurrent fungal infections (HP:0002841)1.79876385
111Deviation of the thumb (HP:0009603)1.79830721
112Villous atrophy (HP:0011473)1.79580032
113Abnormality of small intestinal villus morphology (HP:0011472)1.79580032
114High pitched voice (HP:0001620)1.79221809
115Increased hepatocellular lipid droplets (HP:0006565)1.79218299
116Sparse lateral eyebrow (HP:0005338)1.78973384
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.77472910
118Osteolytic defects of the hand bones (HP:0009699)1.77472910
119Atresia of the external auditory canal (HP:0000413)1.77177146
120Basal cell carcinoma (HP:0002671)1.76873783
121Premature graying of hair (HP:0002216)1.76836568
122Upper limb muscle weakness (HP:0003484)1.76610784
123Trismus (HP:0000211)1.74748007
124Autoamputation (HP:0001218)1.74732489
125Abnormality of the duodenum (HP:0002246)1.73827743
126Acute necrotizing encephalopathy (HP:0006965)1.72446518
127Leukopenia (HP:0001882)1.71393375
128Cafe-au-lait spot (HP:0000957)1.70384583
129Recurrent abscess formation (HP:0002722)1.70357872
130Abnormality of serum amino acid levels (HP:0003112)1.70034837
131Cellular immunodeficiency (HP:0005374)1.69642330
132Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69332229
133Progressive muscle weakness (HP:0003323)1.69271790
134Squamous cell carcinoma (HP:0002860)1.68699736
135Abnormalities of placenta or umbilical cord (HP:0001194)1.68483691
136T lymphocytopenia (HP:0005403)1.68473455
137Shoulder girdle muscle weakness (HP:0003547)1.67939427
138Lower limb hyperreflexia (HP:0002395)1.67916566
139Cerebral edema (HP:0002181)1.67701267
140Absent forearm bone (HP:0003953)1.67517350
141Aplasia involving forearm bones (HP:0009822)1.67517350
142Abnormal trabecular bone morphology (HP:0100671)1.67050141
143Premature ovarian failure (HP:0008209)1.66689655
144Rhabdomyolysis (HP:0003201)1.66257180
14511 pairs of ribs (HP:0000878)1.65394843
146Conjunctival hamartoma (HP:0100780)1.65231352
147Type 2 muscle fiber atrophy (HP:0003554)1.64733107
148Progressive macrocephaly (HP:0004481)1.64718979
149Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64694247
150Breech presentation (HP:0001623)1.64659156
151Methylmalonic acidemia (HP:0002912)1.64415702
152Acute encephalopathy (HP:0006846)1.63573677
153Pallor (HP:0000980)1.62197237
154Abnormal biliary tract morphology (HP:0012440)1.61929116
155Tracheoesophageal fistula (HP:0002575)1.61029001
156Abnormality of the carotid arteries (HP:0005344)1.59291259
157Amaurosis fugax (HP:0100576)1.59184592
158Secondary amenorrhea (HP:0000869)1.58656196
159Short middle phalanx of the 5th finger (HP:0004220)1.57720609
160Spinal cord lesions (HP:0100561)1.57628204
161Syringomyelia (HP:0003396)1.57628204
162Areflexia of lower limbs (HP:0002522)1.57351898
163Pulmonary fibrosis (HP:0002206)1.55580856
164Sparse eyelashes (HP:0000653)1.55054309
165Rectal prolapse (HP:0002035)1.54980810
166Abnormality of T cell number (HP:0011839)1.54894861
167Neoplasm of the colon (HP:0100273)1.54564210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.89857080
2WEE13.38249166
3CDC73.25819849
4BUB13.10030165
5NEK23.06437891
6BRSK22.97626763
7CDK122.49812565
8EIF2AK12.34852587
9PBK2.34495551
10NUAK12.23092544
11ACVR1B2.14726094
12NME22.10773350
13PLK41.97526956
14TTK1.92280314
15TRIM281.92169145
16PDK21.89829831
17STK101.84890323
18MAP4K11.77489751
19CDK71.66032255
20PLK11.65275098
21BMPR1B1.62798401
22SRPK11.61033150
23AURKB1.53755755
24CDK41.53133067
25STK31.51709199
26STK41.45481528
27EEF2K1.45314177
28EIF2AK31.42502032
29YES11.41638928
30MAP3K121.41586503
31DYRK31.41400941
32CHEK21.41023653
33ATR1.37598373
34BRSK11.32068613
35NEK11.30683609
36LATS11.29961961
37BMPR21.28882448
38FLT31.27142134
39MAP2K31.26126183
40MST1R1.22731735
41RPS6KB21.21835565
42MAP3K81.20477766
43PIM11.19862849
44CDK61.19463185
45TEC1.18376153
46MKNK11.16700493
47ERBB31.15551120
48MKNK21.15168082
49TAF11.14991142
50ZAP701.11332839
51MAP3K101.11112322
52JAK31.10750728
53CDK81.07992586
54PLK31.07317180
55EPHA21.05746141
56NEK91.05305397
57CHEK11.04080671
58* RPS6KA41.02514846
59FRK1.00523520
60VRK10.98302256
61IRAK20.97283695
62OBSCN0.96754128
63VRK20.96607493
64NLK0.96377042
65IRAK30.93395938
66ZAK0.92183823
67MAP3K30.92065938
68PASK0.91367183
69ILK0.90959049
70PIM20.90867127
71TXK0.90599458
72STK240.90460352
73CLK10.87078942
74PKN20.85217454
75TSSK60.84695887
76MARK30.84226291
77IRAK10.84143651
78BTK0.83785459
79TYK20.82888685
80TESK20.82192400
81ERBB40.80925116
82NEK60.80574978
83PAK40.79749256
84MELK0.79554075
85ATM0.79322466
86IRAK40.78622202
87TGFBR10.76738841
88KDR0.75378689
89LRRK20.73663830
90TAOK30.72740771
91STK38L0.72448641
92TRPM70.72355983
93PIK3CG0.70419872
94AURKA0.70287075
95CDK20.69461081
96TGFBR20.68409097
97MAP4K20.68174750
98AKT30.66387591
99SIK30.65186807
100BRD40.65088015
101CDK90.63730379
102KIT0.62192847
103CHUK0.62178121
104ERN10.60593067
105IKBKB0.59412549
106EIF2AK20.58120525
107TAOK10.57273391
108MTOR0.57011858
109RAF10.55548914
110PDK40.55464635
111PDK30.55464635
112MAP3K50.54343618
113MAPK110.53219146
114SCYL20.53149385
115STK160.52116475
116CSF1R0.50991489
117DMPK0.50234230
118MAP3K110.49926122
119ITK0.49226468
120BRAF0.48107910
121CCNB10.47889941
122MAP3K60.47022746
123* CSNK2A10.46975319
124MAP3K140.45020664
125MAPKAPK30.44800378
126STK390.44505499
127CDK190.44384912
128TRIB30.43938340
129TTN0.43657748
130* CSNK2A20.42400642
131ALK0.42169281
132NME10.31496391
133MAP3K20.30935067
134CSNK1G10.27397733
135CDK10.26852564
136MET0.25473967

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80045084
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30573185
3Mismatch repair_Homo sapiens_hsa034303.25312614
4RNA transport_Homo sapiens_hsa030132.87967622
5Cell cycle_Homo sapiens_hsa041102.86876085
6Homologous recombination_Homo sapiens_hsa034402.59457770
7Spliceosome_Homo sapiens_hsa030402.50254682
8Base excision repair_Homo sapiens_hsa034102.49865935
9RNA polymerase_Homo sapiens_hsa030202.48373055
10Nucleotide excision repair_Homo sapiens_hsa034202.21987447
11One carbon pool by folate_Homo sapiens_hsa006702.17681230
12Ribosome_Homo sapiens_hsa030102.11142757
13Basal transcription factors_Homo sapiens_hsa030222.10623834
14Fanconi anemia pathway_Homo sapiens_hsa034602.07012888
15p53 signaling pathway_Homo sapiens_hsa041151.96013065
16RNA degradation_Homo sapiens_hsa030181.89357640
17Pyrimidine metabolism_Homo sapiens_hsa002401.88631631
18Vitamin B6 metabolism_Homo sapiens_hsa007501.84441766
19Non-homologous end-joining_Homo sapiens_hsa034501.81660815
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68867358
21Proteasome_Homo sapiens_hsa030501.63905443
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54704621
23mRNA surveillance pathway_Homo sapiens_hsa030151.46529036
24Herpes simplex infection_Homo sapiens_hsa051681.44695395
25Antigen processing and presentation_Homo sapiens_hsa046121.35627415
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23187391
27Folate biosynthesis_Homo sapiens_hsa007901.18404019
28Epstein-Barr virus infection_Homo sapiens_hsa051691.16423748
29Primary immunodeficiency_Homo sapiens_hsa053401.14659554
30Pentose phosphate pathway_Homo sapiens_hsa000301.14009216
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.07886513
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04373949
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03482384
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01320647
35Selenocompound metabolism_Homo sapiens_hsa004500.99491809
36Small cell lung cancer_Homo sapiens_hsa052220.96915565
37Propanoate metabolism_Homo sapiens_hsa006400.96679379
38Viral carcinogenesis_Homo sapiens_hsa052030.96177101
39Purine metabolism_Homo sapiens_hsa002300.93800231
40Measles_Homo sapiens_hsa051620.92764041
41Pyruvate metabolism_Homo sapiens_hsa006200.92553134
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90413774
43Legionellosis_Homo sapiens_hsa051340.88540265
44* HTLV-I infection_Homo sapiens_hsa051660.86537651
45Oxidative phosphorylation_Homo sapiens_hsa001900.86151934
46MicroRNAs in cancer_Homo sapiens_hsa052060.80849087
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.78467352
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78243113
49Thyroid cancer_Homo sapiens_hsa052160.78204825
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.77912995
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77335174
52Fatty acid elongation_Homo sapiens_hsa000620.75806301
53* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73045832
54Leishmaniasis_Homo sapiens_hsa051400.72748014
55Hepatitis B_Homo sapiens_hsa051610.72428642
56Hematopoietic cell lineage_Homo sapiens_hsa046400.72240622
57Apoptosis_Homo sapiens_hsa042100.71868989
58Chronic myeloid leukemia_Homo sapiens_hsa052200.69921783
59Circadian rhythm_Homo sapiens_hsa047100.69805009
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.69713632
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.68415971
62Acute myeloid leukemia_Homo sapiens_hsa052210.67016096
63Biosynthesis of amino acids_Homo sapiens_hsa012300.66254157
64Huntingtons disease_Homo sapiens_hsa050160.66150611
65Parkinsons disease_Homo sapiens_hsa050120.65817779
66Sulfur relay system_Homo sapiens_hsa041220.61834711
67Influenza A_Homo sapiens_hsa051640.61247229
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60296953
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59858059
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59713247
71TGF-beta signaling pathway_Homo sapiens_hsa043500.59706720
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59578155
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58539470
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57299436
75Pancreatic cancer_Homo sapiens_hsa052120.55868987
76Viral myocarditis_Homo sapiens_hsa054160.55842651
77Adherens junction_Homo sapiens_hsa045200.55497874
78Oocyte meiosis_Homo sapiens_hsa041140.52352874
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52186441
80Shigellosis_Homo sapiens_hsa051310.50727588
81B cell receptor signaling pathway_Homo sapiens_hsa046620.49079353
82FoxO signaling pathway_Homo sapiens_hsa040680.48776712
83Osteoclast differentiation_Homo sapiens_hsa043800.48038625
84Colorectal cancer_Homo sapiens_hsa052100.47455205
85Lysine degradation_Homo sapiens_hsa003100.46892255
86Notch signaling pathway_Homo sapiens_hsa043300.46364306
87mTOR signaling pathway_Homo sapiens_hsa041500.44282758
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43848435
89Toxoplasmosis_Homo sapiens_hsa051450.43802790
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43089076
91Regulation of autophagy_Homo sapiens_hsa041400.42880661
92Non-small cell lung cancer_Homo sapiens_hsa052230.42682197
93Bladder cancer_Homo sapiens_hsa052190.42426406
94Prostate cancer_Homo sapiens_hsa052150.41245171
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40877344
96HIF-1 signaling pathway_Homo sapiens_hsa040660.40291412
97Systemic lupus erythematosus_Homo sapiens_hsa053220.40050698
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39962738
99Asthma_Homo sapiens_hsa053100.37772302
100Steroid biosynthesis_Homo sapiens_hsa001000.37620627
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.37448031
102Metabolic pathways_Homo sapiens_hsa011000.37418507
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37229131
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36801222
105Caffeine metabolism_Homo sapiens_hsa002320.36471825
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35912896
107Sulfur metabolism_Homo sapiens_hsa009200.35853666
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.35596342
109Protein export_Homo sapiens_hsa030600.35470366
110N-Glycan biosynthesis_Homo sapiens_hsa005100.34899561
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34618362
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.33486306
113Glutathione metabolism_Homo sapiens_hsa004800.33252629
114TNF signaling pathway_Homo sapiens_hsa046680.33029201
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32664736
116Carbon metabolism_Homo sapiens_hsa012000.32437131
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32063998
118Pathways in cancer_Homo sapiens_hsa052000.31345001
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31032183
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31001134
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30591991
122Galactose metabolism_Homo sapiens_hsa000520.29358927
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29348466
124Melanoma_Homo sapiens_hsa052180.28208196
125Alzheimers disease_Homo sapiens_hsa050100.28131280
126T cell receptor signaling pathway_Homo sapiens_hsa046600.27363610

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