ATF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.35296120
2synaptic vesicle exocytosis (GO:0016079)4.36319407
3neuron cell-cell adhesion (GO:0007158)4.31357174
4nucleobase catabolic process (GO:0046113)4.31144370
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28981259
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.23322209
7vocalization behavior (GO:0071625)4.21429192
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.20255972
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.19256246
10glutamate secretion (GO:0014047)4.19151504
11regulation of synaptic vesicle exocytosis (GO:2000300)4.17823486
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.15594766
13neural tube formation (GO:0001841)4.12564630
14regulation of synaptic vesicle transport (GO:1902803)3.91232628
15regulation of glutamate receptor signaling pathway (GO:1900449)3.89691701
16protein localization to synapse (GO:0035418)3.88497814
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77003652
18presynaptic membrane assembly (GO:0097105)3.72186002
19neuron recognition (GO:0008038)3.67937831
20startle response (GO:0001964)3.67404280
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.66835433
22synaptic vesicle maturation (GO:0016188)3.61565349
23gamma-aminobutyric acid transport (GO:0015812)3.53510425
24axonal fasciculation (GO:0007413)3.53427153
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47335995
26positive regulation of dendritic spine morphogenesis (GO:0061003)3.46465593
27locomotory exploration behavior (GO:0035641)3.46361703
28cerebellar Purkinje cell differentiation (GO:0021702)3.40789718
29nerve growth factor signaling pathway (GO:0038180)3.39792074
30glutamate receptor signaling pathway (GO:0007215)3.36856730
31neuron-neuron synaptic transmission (GO:0007270)3.36661156
32positive regulation of amino acid transport (GO:0051957)3.36558395
33synaptic transmission, glutamatergic (GO:0035249)3.34436039
34presynaptic membrane organization (GO:0097090)3.31970764
35DNA double-strand break processing (GO:0000729)3.29871769
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.27230873
37long-term synaptic potentiation (GO:0060291)3.25523104
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20595214
39dendritic spine morphogenesis (GO:0060997)3.19798690
40neurotransmitter secretion (GO:0007269)3.18571469
41synaptic vesicle endocytosis (GO:0048488)3.17841724
42intraciliary transport (GO:0042073)3.17471677
43righting reflex (GO:0060013)3.13657918
44neuronal action potential propagation (GO:0019227)3.12804551
45response to pheromone (GO:0019236)3.11712110
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11056714
47central nervous system projection neuron axonogenesis (GO:0021952)3.10156187
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09211409
49regulation of neuronal synaptic plasticity (GO:0048168)3.03086949
50postsynaptic membrane organization (GO:0001941)3.02574648
51exploration behavior (GO:0035640)3.01273114
52auditory behavior (GO:0031223)3.00379164
53mechanosensory behavior (GO:0007638)2.98676613
54regulation of meiosis I (GO:0060631)2.97285848
55response to histamine (GO:0034776)2.96569546
56long-term memory (GO:0007616)2.92184418
57innervation (GO:0060384)2.89108802
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87473317
59regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87364857
60regulation of sarcomere organization (GO:0060297)2.87103920
61positive regulation of membrane potential (GO:0045838)2.87003736
62regulation of neurotransmitter secretion (GO:0046928)2.86798586
63dendrite development (GO:0016358)2.86213746
64neurotransmitter-gated ion channel clustering (GO:0072578)2.85735604
65regulation of postsynaptic membrane potential (GO:0060078)2.85670788
66negative regulation of dendrite development (GO:2000171)2.85612587
67layer formation in cerebral cortex (GO:0021819)2.85325377
68protein localization to cilium (GO:0061512)2.84330753
69regulation of development, heterochronic (GO:0040034)2.84018183
70negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83531936
71regulation of synaptic transmission, glutamatergic (GO:0051966)2.81463016
72negative regulation of DNA recombination (GO:0045910)2.81135600
73protein prenylation (GO:0018342)2.80305294
74prenylation (GO:0097354)2.80305294
75cerebral cortex radially oriented cell migration (GO:0021799)2.79910444
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79095788
77regulation of synaptic transmission, GABAergic (GO:0032228)2.75857392
78negative regulation of dendrite morphogenesis (GO:0050774)2.75360303
79establishment of protein localization to Golgi (GO:0072600)2.74472168
80proline transport (GO:0015824)2.74392976
81transmission of nerve impulse (GO:0019226)2.74019184
82retinal ganglion cell axon guidance (GO:0031290)2.73994737
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73682258
84regulation of timing of cell differentiation (GO:0048505)2.72379407
85photoreceptor cell maintenance (GO:0045494)2.71999425
86cochlea development (GO:0090102)2.71710944
87cerebral cortex cell migration (GO:0021795)2.71476575
88negative regulation of neurotransmitter transport (GO:0051589)2.70741670
89behavioral defense response (GO:0002209)2.70458345
90behavioral fear response (GO:0001662)2.70458345
91microtubule anchoring (GO:0034453)2.70450139
92protein targeting to Golgi (GO:0000042)2.70255050
93regulation of synaptic plasticity (GO:0048167)2.69093162
94striatum development (GO:0021756)2.68753358
95olfactory bulb development (GO:0021772)2.68405072
96response to auditory stimulus (GO:0010996)2.67792641
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64527131
98regulation of respiratory system process (GO:0044065)2.63809266
99regulation of dendritic spine morphogenesis (GO:0061001)2.63502668
100protein K11-linked deubiquitination (GO:0035871)2.63340253
101serotonin metabolic process (GO:0042428)2.63276277
102hippocampus development (GO:0021766)2.63197455
103positive regulation of synapse assembly (GO:0051965)2.63157138
104positive regulation of mRNA catabolic process (GO:0061014)2.61159843
105synapse assembly (GO:0007416)2.61089682
106RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61071923
107regulation of neurotransmitter transport (GO:0051588)2.60597524
108neurotransmitter transport (GO:0006836)2.59805643
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.59535058
110histone H2A acetylation (GO:0043968)2.59527578
111positive regulation of mRNA metabolic process (GO:1903313)2.59335876
112epithelial cilium movement (GO:0003351)2.59092842
113vesicle transport along microtubule (GO:0047496)2.58132145
114hindbrain development (GO:0030902)2.58093425
115positive regulation of mitochondrial fission (GO:0090141)2.57789203
116regulation of dendritic spine development (GO:0060998)2.56756841
117learning (GO:0007612)2.55960159
118glycosphingolipid biosynthetic process (GO:0006688)2.55927735
119detection of calcium ion (GO:0005513)2.55922242
120pancreas development (GO:0031016)2.55666908
121dendrite morphogenesis (GO:0048813)2.55219396
122fear response (GO:0042596)2.53830738
123calcium ion-dependent exocytosis (GO:0017156)2.52902118
124positive regulation of meiosis (GO:0045836)2.52882578
125cerebellar granule cell differentiation (GO:0021707)2.52702689
126calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51118401
127serotonin receptor signaling pathway (GO:0007210)2.50282607
128central nervous system neuron axonogenesis (GO:0021955)2.49166840
129establishment of synaptic vesicle localization (GO:0097480)2.49071209
130synaptic vesicle transport (GO:0048489)2.49071209
131regulation of synapse assembly (GO:0051963)2.48680090
132positive regulation of synapse maturation (GO:0090129)2.48483799
133establishment of vesicle localization (GO:0051650)2.48476261
134membrane hyperpolarization (GO:0060081)2.48126426
135regulation of glutamate secretion (GO:0014048)2.48038383
136retinal cone cell development (GO:0046549)2.47747441
137regulation of vesicle fusion (GO:0031338)2.47515864
138positive regulation of synaptic transmission (GO:0050806)2.47466899
139positive regulation of dendrite morphogenesis (GO:0050775)2.47375547
140limb bud formation (GO:0060174)2.47062395
141head development (GO:0060322)2.46141200
142heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.45617005
143urinary tract smooth muscle contraction (GO:0014848)2.45207757
144regulation of clathrin-mediated endocytosis (GO:2000369)2.44938190
145inositol phosphate catabolic process (GO:0071545)2.44839175
146cilium organization (GO:0044782)2.44292780
147negative regulation of neurotransmitter secretion (GO:0046929)2.44036705
148regulation of cAMP-dependent protein kinase activity (GO:2000479)2.43336993
149cilium assembly (GO:0042384)2.43096119
150retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42957566
151nonmotile primary cilium assembly (GO:0035058)2.42491941
152cilium morphogenesis (GO:0060271)2.40911742
153regulation of Rac protein signal transduction (GO:0035020)2.40474877
154gene silencing by RNA (GO:0031047)2.40140186
155adult walking behavior (GO:0007628)2.40098825
156regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.38900885
157detection of light stimulus involved in visual perception (GO:0050908)2.38660605
158detection of light stimulus involved in sensory perception (GO:0050962)2.38660605
159acrosome reaction (GO:0007340)2.38561988
160vesicle localization (GO:0051648)2.38260168
161appendage development (GO:0048736)2.37392525
162limb development (GO:0060173)2.37392525
163negative regulation of astrocyte differentiation (GO:0048712)2.36467644
164protein-chromophore linkage (GO:0018298)2.36339347
165negative regulation of translation, ncRNA-mediated (GO:0040033)2.35759396
166regulation of translation, ncRNA-mediated (GO:0045974)2.35759396
167negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35759396
168polyol catabolic process (GO:0046174)2.33161951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28273332
2GBX2_23144817_ChIP-Seq_PC3_Human3.88209526
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78982535
4TAF15_26573619_Chip-Seq_HEK293_Human2.54828799
5IGF1R_20145208_ChIP-Seq_DFB_Human2.51305071
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44900840
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32598420
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.31454692
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20976550
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20073900
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19699430
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13064721
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.12130841
14REST_21632747_ChIP-Seq_MESCs_Mouse2.10264224
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09024866
16P300_19829295_ChIP-Seq_ESCs_Human2.07572736
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07398161
18FUS_26573619_Chip-Seq_HEK293_Human2.05711099
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.02990023
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01462176
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94044352
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.91642946
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91498954
24SMAD4_21799915_ChIP-Seq_A2780_Human1.89725504
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82883952
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81261413
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81070653
28AR_21572438_ChIP-Seq_LNCaP_Human1.79546328
29* RNF2_27304074_Chip-Seq_NSC_Mouse1.78383294
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76408237
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75974994
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75411328
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.72433882
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70637605
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67835609
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67835609
37* CBX2_27304074_Chip-Seq_ESCs_Mouse1.67187951
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.67150333
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66608535
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63451707
41STAT3_23295773_ChIP-Seq_U87_Human1.63423881
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.61936990
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61726166
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.60600824
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60581117
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.59560987
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59259912
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54417356
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53739736
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52605567
51EWS_26573619_Chip-Seq_HEK293_Human1.50453919
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48871674
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48704954
54ZNF274_21170338_ChIP-Seq_K562_Hela1.48599078
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48498725
56AR_25329375_ChIP-Seq_VCAP_Human1.47245816
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47078722
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.46737327
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46187504
60CBP_20019798_ChIP-Seq_JUKART_Human1.46187504
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.45493581
62* NANOG_18555785_Chip-Seq_ESCs_Mouse1.44990337
63TCF4_23295773_ChIP-Seq_U87_Human1.44316469
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44037623
65ER_23166858_ChIP-Seq_MCF-7_Human1.43100308
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.41943790
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39899858
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39899858
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39227493
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38546287
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37549866
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.36443180
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.36214541
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34464782
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33918108
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.32861385
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31909575
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31867736
79* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31199818
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31012334
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31003136
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29926297
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27755325
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27644466
85DROSHA_22980978_ChIP-Seq_HELA_Human1.27445096
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.26099646
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.25683640
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24557971
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.24277648
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23151624
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21927722
92VDR_22108803_ChIP-Seq_LS180_Human1.21716682
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19754944
94P300_18555785_Chip-Seq_ESCs_Mouse1.19497529
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19325969
96* E2F1_18555785_Chip-Seq_ESCs_Mouse1.18650016
97* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18353494
98TCF4_22108803_ChIP-Seq_LS180_Human1.17967701
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17513290
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.17448756
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.16575790
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16362358
103* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16156587
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15984548
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14923320
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14574927
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13833669
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13833669
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.11949570
110JUN_21703547_ChIP-Seq_K562_Human1.11647415
111* AR_19668381_ChIP-Seq_PC3_Human1.11603561
112* SOX9_26525672_Chip-Seq_HEART_Mouse1.11394938
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.10302272
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.09207251
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.09087944
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09028030
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08992180
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08547151
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08223331
120* P53_22387025_ChIP-Seq_ESCs_Mouse1.08173572
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07808805
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.07522144
123SOX2_18555785_Chip-Seq_ESCs_Mouse1.07461327
124BCAT_22108803_ChIP-Seq_LS180_Human1.07369361
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.07215574
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06856677
127KDM2B_26808549_Chip-Seq_REH_Human1.06685061
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06294345
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05900629
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.05301694
131* OCT4_18555785_Chip-Seq_ESCs_Mouse1.04823054
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04557215
133* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03686676
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03567737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.28776749
2MP0004859_abnormal_synaptic_plasticity4.20995676
3MP0003122_maternal_imprinting3.15124606
4MP0003635_abnormal_synaptic_transmissio3.11961660
5MP0004270_analgesia3.03104972
6MP0003787_abnormal_imprinting2.85980764
7MP0005646_abnormal_pituitary_gland2.64363694
8MP0002063_abnormal_learning/memory/cond2.63476917
9MP0005645_abnormal_hypothalamus_physiol2.51861307
10MP0009745_abnormal_behavioral_response2.49078099
11MP0002572_abnormal_emotion/affect_behav2.42211232
12MP0001968_abnormal_touch/_nociception2.41005277
13MP0001188_hyperpigmentation2.39244556
14MP0009046_muscle_twitch2.39132280
15MP0003121_genomic_imprinting2.34684469
16MP0001529_abnormal_vocalization2.32866218
17MP0002734_abnormal_mechanical_nocicepti2.28399200
18MP0002064_seizures2.27771983
19MP0001486_abnormal_startle_reflex2.14397647
20MP0000778_abnormal_nervous_system2.11059226
21MP0001984_abnormal_olfaction2.06989981
22MP0006292_abnormal_olfactory_placode1.98836875
23MP0006276_abnormal_autonomic_nervous1.98609894
24MP0005423_abnormal_somatic_nervous1.97431995
25MP0002735_abnormal_chemical_nociception1.96087414
26MP0000569_abnormal_digit_pigmentation1.92335655
27MP0002272_abnormal_nervous_system1.84792332
28MP0005386_behavior/neurological_phenoty1.84328276
29MP0004924_abnormal_behavior1.84328276
30MP0002736_abnormal_nociception_after1.82266987
31MP0008877_abnormal_DNA_methylation1.77667517
32MP0002557_abnormal_social/conspecific_i1.73388116
33MP0009697_abnormal_copulation1.70479337
34MP0003195_calcinosis1.70310225
35MP0005253_abnormal_eye_physiology1.68815984
36MP0002067_abnormal_sensory_capabilities1.67890867
37MP0002184_abnormal_innervation1.66355930
38MP0009780_abnormal_chondrocyte_physiolo1.60675400
39MP0001501_abnormal_sleep_pattern1.54080145
40MP0002733_abnormal_thermal_nociception1.54068508
41MP0003890_abnormal_embryonic-extraembry1.53393893
42MP0000631_abnormal_neuroendocrine_gland1.49050085
43MP0001970_abnormal_pain_threshold1.48358213
44MP0001502_abnormal_circadian_rhythm1.45672867
45MP0001440_abnormal_grooming_behavior1.42097731
46MP0004811_abnormal_neuron_physiology1.40883135
47MP0010386_abnormal_urinary_bladder1.34214054
48MP0002638_abnormal_pupillary_reflex1.30446018
49MP0004147_increased_porphyrin_level1.28605022
50MP0000955_abnormal_spinal_cord1.27516392
51MP0005499_abnormal_olfactory_system1.24810358
52MP0005394_taste/olfaction_phenotype1.24810358
53MP0003123_paternal_imprinting1.22958411
54MP0003567_abnormal_fetal_cardiomyocyte1.22957467
55* MP0002882_abnormal_neuron_morphology1.22819405
56MP0002102_abnormal_ear_morphology1.17502068
57* MP0002152_abnormal_brain_morphology1.17020514
58MP0002160_abnormal_reproductive_system1.14564291
59MP0001905_abnormal_dopamine_level1.11802063
60MP0005084_abnormal_gallbladder_morpholo1.11031498
61MP0004134_abnormal_chest_morphology1.09277850
62* MP0002066_abnormal_motor_capabilities/c1.06909247
63MP0004215_abnormal_myocardial_fiber1.06079857
64MP0001764_abnormal_homeostasis1.03443849
65* MP0008569_lethality_at_weaning1.02958611
66MP0002822_catalepsy1.02714785
67MP0002233_abnormal_nose_morphology1.01900325
68MP0008789_abnormal_olfactory_epithelium1.01797124
69MP0003861_abnormal_nervous_system0.98638067
70MP0004133_heterotaxia0.97524768
71MP0002909_abnormal_adrenal_gland0.95857490
72MP0003879_abnormal_hair_cell0.95627007
73MP0004885_abnormal_endolymph0.94527249
74MP0001177_atelectasis0.93442829
75MP0005195_abnormal_posterior_eye0.92646075
76MP0003221_abnormal_cardiomyocyte_apopto0.92367065
77MP0002229_neurodegeneration0.91040167
78MP0005551_abnormal_eye_electrophysiolog0.90379320
79MP0003943_abnormal_hepatobiliary_system0.89064677
80MP0001919_abnormal_reproductive_system0.88759174
81MP0002837_dystrophic_cardiac_calcinosis0.88566798
82MP0000647_abnormal_sebaceous_gland0.86770915
83MP0001929_abnormal_gametogenesis0.86557851
84MP0008057_abnormal_DNA_replication0.85024455
85MP0002234_abnormal_pharynx_morphology0.84390981
86MP0000427_abnormal_hair_cycle0.83557355
87MP0005389_reproductive_system_phenotype0.82241161
88MP0006054_spinal_hemorrhage0.81358662
89MP0002069_abnormal_eating/drinking_beha0.80914232
90MP0005248_abnormal_Harderian_gland0.80278519
91MP0005379_endocrine/exocrine_gland_phen0.80045637
92MP0005187_abnormal_penis_morphology0.79596045
93MP0000566_synostosis0.78693641
94MP0003183_abnormal_peptide_metabolism0.77147672
95MP0008995_early_reproductive_senescence0.77116282
96MP0005391_vision/eye_phenotype0.77038696
97MP0004742_abnormal_vestibular_system0.76958630
98MP0001324_abnormal_eye_pigmentation0.76676644
99MP0003119_abnormal_digestive_system0.75832908
100MP0002938_white_spotting0.75148420
101MP0005409_darkened_coat_color0.73998208
102MP0003698_abnormal_male_reproductive0.73874166
103* MP0002752_abnormal_somatic_nervous0.72715351
104MP0000383_abnormal_hair_follicle0.71729876
105MP0002653_abnormal_ependyma_morphology0.71206722
106* MP0001963_abnormal_hearing_physiology0.70512494
107MP0002876_abnormal_thyroid_physiology0.69381028
108MP0003631_nervous_system_phenotype0.69153232
109MP0004142_abnormal_muscle_tone0.69140273
110MP0001299_abnormal_eye_distance/0.68717735
111MP0003755_abnormal_palate_morphology0.68305533
112MP0005171_absent_coat_pigmentation0.67758337
113MP0001485_abnormal_pinna_reflex0.67302191
114MP0006072_abnormal_retinal_apoptosis0.67093515
115MP0000516_abnormal_urinary_system0.66926934
116MP0005367_renal/urinary_system_phenotyp0.66926934
117MP0008961_abnormal_basal_metabolism0.65157406
118MP0002751_abnormal_autonomic_nervous0.64980856
119MP0001986_abnormal_taste_sensitivity0.63978632
120MP0003937_abnormal_limbs/digits/tail_de0.63601637
121MP0003633_abnormal_nervous_system0.62018431
122MP0003385_abnormal_body_wall0.60801379
123MP0004233_abnormal_muscle_weight0.59737993
124* MP0001943_abnormal_respiration0.59734930
125* MP0002081_perinatal_lethality0.59717251
126MP0003632_abnormal_nervous_system0.58978860
127MP0003938_abnormal_ear_development0.58720241
128MP0002177_abnormal_outer_ear0.58517477
129MP0002116_abnormal_craniofacial_bone0.57975119
130* MP0010770_preweaning_lethality0.57888737

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.66513140
2Epileptic encephalopathy (HP:0200134)3.91945795
3Febrile seizures (HP:0002373)3.89376522
4Focal seizures (HP:0007359)3.82733637
5Abnormality of the labia minora (HP:0012880)3.55401679
6Atonic seizures (HP:0010819)3.55148359
7Abnormal hair whorl (HP:0010721)3.49623120
8Hyperventilation (HP:0002883)3.35724414
9Progressive cerebellar ataxia (HP:0002073)3.34639126
10Papillary thyroid carcinoma (HP:0002895)3.21276143
11Tubulointerstitial nephritis (HP:0001970)3.21085850
12Gait imbalance (HP:0002141)3.12179678
13Visual hallucinations (HP:0002367)3.09879490
14Renal cortical cysts (HP:0000803)3.06511582
15Protruding tongue (HP:0010808)2.89704562
16Broad-based gait (HP:0002136)2.89303967
17Drooling (HP:0002307)2.88011033
18Excessive salivation (HP:0003781)2.88011033
19Exotropia (HP:0000577)2.87488997
20Absence seizures (HP:0002121)2.86952795
21Absent speech (HP:0001344)2.86193726
22Congenital primary aphakia (HP:0007707)2.81186489
23Nephrogenic diabetes insipidus (HP:0009806)2.79069462
24Medial flaring of the eyebrow (HP:0010747)2.74777226
25Abnormality of the renal cortex (HP:0011035)2.66951874
26Myokymia (HP:0002411)2.65333506
27Dialeptic seizures (HP:0011146)2.65276590
28Genetic anticipation (HP:0003743)2.65108412
29Hemiparesis (HP:0001269)2.64302603
30Amyotrophic lateral sclerosis (HP:0007354)2.61318041
31Abnormality of the renal medulla (HP:0100957)2.55198075
32Intestinal atresia (HP:0011100)2.47444368
33Poor coordination (HP:0002370)2.42850752
34Pancreatic cysts (HP:0001737)2.42142445
35Generalized tonic-clonic seizures (HP:0002069)2.39413268
36Genital tract atresia (HP:0001827)2.38093231
37Gaze-evoked nystagmus (HP:0000640)2.38043165
38Generalized hypopigmentation of hair (HP:0011358)2.34897703
39Fair hair (HP:0002286)2.34266083
40Epileptiform EEG discharges (HP:0011182)2.33976868
41Thyroid carcinoma (HP:0002890)2.33231659
42Submucous cleft hard palate (HP:0000176)2.31752506
43Vaginal atresia (HP:0000148)2.30134050
44Chronic hepatic failure (HP:0100626)2.28228255
45Absent eyebrow (HP:0002223)2.27070528
46Poor eye contact (HP:0000817)2.26209320
47Polyphagia (HP:0002591)2.25061105
48Urinary bladder sphincter dysfunction (HP:0002839)2.22249868
49Methylmalonic acidemia (HP:0002912)2.20018448
50Blue irides (HP:0000635)2.19517740
51Postaxial foot polydactyly (HP:0001830)2.18350865
52EEG with generalized epileptiform discharges (HP:0011198)2.17330436
53Specific learning disability (HP:0001328)2.14442360
54Tubulointerstitial abnormality (HP:0001969)2.13849299
55Impaired vibration sensation in the lower limbs (HP:0002166)2.11711163
56Limb dystonia (HP:0002451)2.10069233
57Widely spaced teeth (HP:0000687)2.08531583
58Abnormal eating behavior (HP:0100738)2.08393914
59Impaired smooth pursuit (HP:0007772)2.08311353
60Sleep apnea (HP:0010535)2.07853067
61Pancreatic fibrosis (HP:0100732)2.07065000
62Curly hair (HP:0002212)2.03842274
63Hypsarrhythmia (HP:0002521)2.03304978
64Truncal ataxia (HP:0002078)2.03259132
65Macroorchidism (HP:0000053)2.02939161
66Hyperglycinemia (HP:0002154)2.01976781
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01024175
68Ulnar claw (HP:0001178)2.00105722
69Hip dysplasia (HP:0001385)1.99580933
70Cystic hygroma (HP:0000476)1.97417491
71Cortical dysplasia (HP:0002539)1.97411806
72Agitation (HP:0000713)1.97177816
73Gastroesophageal reflux (HP:0002020)1.96141660
74Abnormality of macular pigmentation (HP:0008002)1.96057711
75Failure to thrive in infancy (HP:0001531)1.95640859
76Midline defect of the nose (HP:0004122)1.95398296
77Termporal pattern (HP:0011008)1.93899317
78Insidious onset (HP:0003587)1.93899317
79Action tremor (HP:0002345)1.90684825
80Volvulus (HP:0002580)1.89805185
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.89477055
82Absent/shortened dynein arms (HP:0200106)1.89477055
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.89194797
84Abnormality of salivation (HP:0100755)1.88749935
85Impaired social interactions (HP:0000735)1.88343951
86Abnormal social behavior (HP:0012433)1.88343951
87Abnormality of ocular smooth pursuit (HP:0000617)1.85736021
88Amblyopia (HP:0000646)1.85308309
89Narrow nasal bridge (HP:0000446)1.85032475
90Hepatoblastoma (HP:0002884)1.84551748
91Hyperthyroidism (HP:0000836)1.84194853
92Papilledema (HP:0001085)1.83922133
93Inability to walk (HP:0002540)1.83645796
94Labial hypoplasia (HP:0000066)1.83310182
95Abnormality of vitamin B metabolism (HP:0004340)1.83192099
96Progressive inability to walk (HP:0002505)1.82114344
97Aqueductal stenosis (HP:0002410)1.81624612
98Abnormality of the nasal septum (HP:0000419)1.81195596
99Pachygyria (HP:0001302)1.80133051
100Abnormality of the corticospinal tract (HP:0002492)1.78423217
101Aplasia/Hypoplasia of the lens (HP:0008063)1.76371155
102Abnormality of midbrain morphology (HP:0002418)1.75189166
103Molar tooth sign on MRI (HP:0002419)1.75189166
104Decreased testicular size (HP:0008734)1.74705482
105Epidermoid cyst (HP:0200040)1.74173137
106Thickened helices (HP:0000391)1.73843110
107Abnormality of the vitamin B12 metabolism (HP:0004341)1.73639985
108Short foot (HP:0001773)1.73409280
109Spastic tetraplegia (HP:0002510)1.72641679
110Broad foot (HP:0001769)1.71847413
111Shoulder girdle muscle weakness (HP:0003547)1.71563055
112Menstrual irregularities (HP:0000858)1.70748731
113Abnormality of chromosome stability (HP:0003220)1.70245603
114Prominent nasal bridge (HP:0000426)1.70213867
115Neoplasm of the adrenal cortex (HP:0100641)1.69723129
116Status epilepticus (HP:0002133)1.68842137
117Esotropia (HP:0000565)1.68774177
118Astigmatism (HP:0000483)1.68448569
119Supernumerary spleens (HP:0009799)1.67381092
120Hypothermia (HP:0002045)1.67244188
121Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.67106287
122Pheochromocytoma (HP:0002666)1.66627920
123Congenital hepatic fibrosis (HP:0002612)1.66297868
124Abnormality of the astrocytes (HP:0100707)1.65487663
125Astrocytoma (HP:0009592)1.65487663
126Stereotypic behavior (HP:0000733)1.65431751
127Mutism (HP:0002300)1.65424794
128Hypoplastic female external genitalia (HP:0012815)1.63426602
129Abnormal respiratory motile cilium physiology (HP:0012261)1.63267749
130True hermaphroditism (HP:0010459)1.63193897
131Abnormal ciliary motility (HP:0012262)1.62887922
132Nephronophthisis (HP:0000090)1.62424850
133Postaxial hand polydactyly (HP:0001162)1.61417357
134Micropenis (HP:0000054)1.59290355
135Lissencephaly (HP:0001339)1.59092703
136Narrow forehead (HP:0000341)1.58685352
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.58618010
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58618010
139Abnormality of incisor morphology (HP:0011063)1.57709534
140Autism (HP:0000717)1.57311704
141Dysdiadochokinesis (HP:0002075)1.57082873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.71590393
2CASK3.54062166
3MARK13.18179300
4MAP3K43.15600084
5EPHA43.00155376
6MAP2K72.86540227
7MAP4K22.74989702
8SIK32.70192350
9MAP3K122.37684484
10TRIM282.34479395
11AKT32.23788257
12MAP3K92.14606810
13MAPK132.00570311
14MINK11.99785128
15PLK21.91788037
16NTRK21.86766643
17SGK21.77088356
18EPHA31.73133324
19FRK1.68636835
20PINK11.65132615
21PRKD31.64674780
22KSR11.60140677
23MAP2K41.56053582
24PNCK1.46078123
25PRPF4B1.41693547
26TNIK1.41101070
27PAK61.38766327
28LATS21.37994631
29CDK191.36367079
30SGK4941.35728593
31SGK2231.35728593
32CCNB11.31737457
33ERBB31.28509297
34BCR1.25011632
35DAPK21.23518845
36IRAK11.21354907
37CAMKK21.20308762
38EIF2AK31.19343504
39CAMK1G1.19267014
40WNK31.19114178
41ACVR1B1.14186950
42SGK31.12820561
43DAPK11.11031940
44PIK3CA1.07378049
45CSNK1G11.06782440
46INSRR1.05398540
47CDK81.01769396
48CDK31.01109648
49CDK50.98042738
50FGFR20.94720501
51RPS6KA40.94049330
52BMPR20.93088867
53MKNK10.92202740
54NLK0.90226048
55OXSR10.89779152
56DYRK20.88256580
57IRAK20.88095941
58SIK20.87003267
59MAP3K60.86408084
60STK380.85041438
61TGFBR10.84923771
62NUAK10.83419680
63* PLK30.83158338
64STK38L0.83109280
65CAMK2A0.82667605
66LATS10.81924923
67CDK90.81661540
68PRKCG0.80343589
69UHMK10.79656113
70DYRK1A0.77888530
71PLK40.76874374
72BMPR1B0.76836914
73SGK10.76728664
74GRK50.75851913
75NEK60.75791787
76ADRBK20.75287508
77CSNK1G20.74817214
78CDK120.73857427
79GRK70.73057864
80CAMK2B0.71279665
81ERBB40.70023849
82CDK180.65947290
83STK390.65943385
84GRK10.63737312
85MAP3K50.62547504
86BRD40.62116983
87MAPK100.61663262
88STK110.61132581
89CAMK10.60225452
90NTRK10.60173859
91PRKCH0.59298717
92CHEK20.58365758
93RIPK10.57080522
94CDK140.55815602
95CAMK1D0.55216365
96PHKG20.55214949
97PHKG10.55214949
98CLK10.55030207
99STK30.53801604
100MAP3K20.53154675
101BRAF0.53031416
102PKN20.52853288
103* PRKCE0.52004325
104MKNK20.51954687
105CDK150.51925543
106DYRK30.51790330
107RIPK40.51718105
108BRSK10.49962530
109ZAK0.49909582
110MUSK0.48278096
111KSR20.47397049
112ADRBK10.46597760
113RET0.46539656
114CSNK1D0.46514908
115PAK30.45946625
116RPS6KB10.45536554
117MARK20.44827555
118GSK3B0.44629880
119CDK11A0.43926718
120PKN10.42340656
121CSNK1A1L0.42326540
122FGFR30.41941967
123FER0.41813223
124RPS6KA30.41723276
125CAMK40.41649226
126WNK10.40357932
127WEE10.40318792
128TYRO30.39484305
129SRPK10.39445060
130TAOK10.38982841
131PRKAA10.37270603
132TAOK30.36721529
133FGFR10.36227716
134CDK10.35967582
135BRSK20.35062995
136CSNK1G30.34949094
137YES10.34326519
138HIPK20.34227919
139* PRKG10.32325987
140TTK0.31039344
141* ATM0.30998780

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77797205
2Synaptic vesicle cycle_Homo sapiens_hsa047212.84486723
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51423484
4Long-term potentiation_Homo sapiens_hsa047202.45687103
5Circadian entrainment_Homo sapiens_hsa047132.45167267
6Morphine addiction_Homo sapiens_hsa050322.42634375
7GABAergic synapse_Homo sapiens_hsa047272.40366698
8* Amphetamine addiction_Homo sapiens_hsa050312.31788717
9Olfactory transduction_Homo sapiens_hsa047402.29469435
10Glutamatergic synapse_Homo sapiens_hsa047242.23842351
11Protein export_Homo sapiens_hsa030602.09281800
12* Insulin secretion_Homo sapiens_hsa049112.07656184
13* Dopaminergic synapse_Homo sapiens_hsa047282.05577427
14Selenocompound metabolism_Homo sapiens_hsa004502.02837835
15Taste transduction_Homo sapiens_hsa047422.01914456
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97384090
17Serotonergic synapse_Homo sapiens_hsa047261.95225281
18Propanoate metabolism_Homo sapiens_hsa006401.93773528
19* Cocaine addiction_Homo sapiens_hsa050301.75682392
20Cholinergic synapse_Homo sapiens_hsa047251.70650805
21Butanoate metabolism_Homo sapiens_hsa006501.69572037
22Long-term depression_Homo sapiens_hsa047301.69458496
23Steroid biosynthesis_Homo sapiens_hsa001001.64294216
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60346345
25Salivary secretion_Homo sapiens_hsa049701.57781386
26Renin secretion_Homo sapiens_hsa049241.55254242
27Collecting duct acid secretion_Homo sapiens_hsa049661.47110527
28* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46191307
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41474648
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38515007
31Axon guidance_Homo sapiens_hsa043601.38501291
32Type II diabetes mellitus_Homo sapiens_hsa049301.29831167
33ErbB signaling pathway_Homo sapiens_hsa040121.28063030
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26216687
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26176226
36Oocyte meiosis_Homo sapiens_hsa041141.26164485
37Phototransduction_Homo sapiens_hsa047441.25714582
38Oxytocin signaling pathway_Homo sapiens_hsa049211.25465204
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25293819
40Calcium signaling pathway_Homo sapiens_hsa040201.24889426
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24271960
42cAMP signaling pathway_Homo sapiens_hsa040241.24118797
43Gastric acid secretion_Homo sapiens_hsa049711.22642276
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21086168
45Caffeine metabolism_Homo sapiens_hsa002321.19620139
46Fanconi anemia pathway_Homo sapiens_hsa034601.17876764
47Circadian rhythm_Homo sapiens_hsa047101.17065768
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16906508
49GnRH signaling pathway_Homo sapiens_hsa049121.16549348
50Gap junction_Homo sapiens_hsa045401.16076763
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14123142
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12981427
53Dorso-ventral axis formation_Homo sapiens_hsa043201.12514046
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11322962
55Ether lipid metabolism_Homo sapiens_hsa005651.10606266
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07469044
57Glioma_Homo sapiens_hsa052141.07357908
58Vibrio cholerae infection_Homo sapiens_hsa051101.06856413
59Melanogenesis_Homo sapiens_hsa049161.06197328
60* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05444722
61* Estrogen signaling pathway_Homo sapiens_hsa049151.02949577
62Regulation of autophagy_Homo sapiens_hsa041401.02022462
63Endometrial cancer_Homo sapiens_hsa052130.95880548
64Peroxisome_Homo sapiens_hsa041460.94827888
65Wnt signaling pathway_Homo sapiens_hsa043100.94796454
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91935623
67Choline metabolism in cancer_Homo sapiens_hsa052310.91925699
68* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91289896
69Renal cell carcinoma_Homo sapiens_hsa052110.89242876
70Type I diabetes mellitus_Homo sapiens_hsa049400.87384037
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86998114
72Colorectal cancer_Homo sapiens_hsa052100.85412759
73Ras signaling pathway_Homo sapiens_hsa040140.83502958
74* MAPK signaling pathway_Homo sapiens_hsa040100.82385437
75Nitrogen metabolism_Homo sapiens_hsa009100.81808245
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81297370
77* Alcoholism_Homo sapiens_hsa050340.79925372
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.79487572
79Non-homologous end-joining_Homo sapiens_hsa034500.77809327
80Fatty acid biosynthesis_Homo sapiens_hsa000610.77603639
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75439954
82mTOR signaling pathway_Homo sapiens_hsa041500.74736549
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74292334
84Ovarian steroidogenesis_Homo sapiens_hsa049130.73784968
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73679391
86Basal transcription factors_Homo sapiens_hsa030220.72341136
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.70176683
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69897741
89Linoleic acid metabolism_Homo sapiens_hsa005910.68390098
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67860827
91Fatty acid metabolism_Homo sapiens_hsa012120.67046338
92Inositol phosphate metabolism_Homo sapiens_hsa005620.64411858
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64199513
94Prolactin signaling pathway_Homo sapiens_hsa049170.63232178
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62692432
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61686842
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61293709
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61234050
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.60620957
100Melanoma_Homo sapiens_hsa052180.59906567
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59239168
102* Glucagon signaling pathway_Homo sapiens_hsa049220.54379681
103* Thyroid hormone synthesis_Homo sapiens_hsa049180.54050492
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54010184
105* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53815108
106Prostate cancer_Homo sapiens_hsa052150.53245885
107Rap1 signaling pathway_Homo sapiens_hsa040150.53203599
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53043696
109FoxO signaling pathway_Homo sapiens_hsa040680.52741356
110Pancreatic secretion_Homo sapiens_hsa049720.51563719
111RNA transport_Homo sapiens_hsa030130.50328380
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49881497
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.49624285
114Tryptophan metabolism_Homo sapiens_hsa003800.49193952
115Non-small cell lung cancer_Homo sapiens_hsa052230.48169747
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45716328
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44674450
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44538542
119mRNA surveillance pathway_Homo sapiens_hsa030150.44163455
120ABC transporters_Homo sapiens_hsa020100.42721055
121Rheumatoid arthritis_Homo sapiens_hsa053230.42450412
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.41555109
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.40948599
124Hedgehog signaling pathway_Homo sapiens_hsa043400.40945462
125Hippo signaling pathway_Homo sapiens_hsa043900.39416001
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38855964
127Cell cycle_Homo sapiens_hsa041100.38541653
128RNA degradation_Homo sapiens_hsa030180.38478481
129TGF-beta signaling pathway_Homo sapiens_hsa043500.36749174
130MicroRNAs in cancer_Homo sapiens_hsa052060.36556092
131Chemokine signaling pathway_Homo sapiens_hsa040620.36061639
132Adherens junction_Homo sapiens_hsa045200.35962977
133Lysine degradation_Homo sapiens_hsa003100.35707542
134Insulin signaling pathway_Homo sapiens_hsa049100.35539301
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.35109055

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