ATF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.42530657
2microglial cell activation (GO:0001774)4.86573974
3oligosaccharide catabolic process (GO:0009313)4.48270424
4positive regulation by symbiont of host defense response (GO:0052509)4.41320519
5modulation by symbiont of host defense response (GO:0052031)4.41320519
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.41320519
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.41320519
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.41320519
9modulation by symbiont of host immune response (GO:0052553)4.41320519
10response to muramyl dipeptide (GO:0032495)4.36701344
11regulation of chemokine secretion (GO:0090196)4.35589176
12regulation of vitamin metabolic process (GO:0030656)4.25592186
13hemidesmosome assembly (GO:0031581)4.19825390
14regulation of chronic inflammatory response (GO:0002676)4.07360766
15interferon-gamma secretion (GO:0072643)4.04303121
16glycosphingolipid catabolic process (GO:0046479)3.98980705
17macrophage activation (GO:0042116)3.85593068
18cellular response to thyroid hormone stimulus (GO:0097067)3.76359319
19regulation of T-helper 1 cell differentiation (GO:0045625)3.75399602
20glycolipid catabolic process (GO:0019377)3.73252806
21desmosome organization (GO:0002934)3.72849516
22negative regulation of interleukin-12 production (GO:0032695)3.71211693
23regulation of chemokine biosynthetic process (GO:0045073)3.69527089
24macrophage activation involved in immune response (GO:0002281)3.69181485
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63970301
26positive regulation of chemokine secretion (GO:0090197)3.63288156
27T-helper 1 type immune response (GO:0042088)3.60025472
28positive regulation of cellular amide metabolic process (GO:0034250)3.49490206
29positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.47973668
30regulation of cytokine secretion involved in immune response (GO:0002739)3.41181871
31positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.37910073
32positive regulation of p38MAPK cascade (GO:1900745)3.37653690
33positive regulation of nitric oxide biosynthetic process (GO:0045429)3.37210009
34regulation of nitric oxide biosynthetic process (GO:0045428)3.32530736
35positive regulation of type 2 immune response (GO:0002830)3.27998437
36G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.27619340
37negative regulation of nitric oxide biosynthetic process (GO:0045019)3.27292152
38response to peptidoglycan (GO:0032494)3.25444502
39regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.25157625
40regulation of membrane protein ectodomain proteolysis (GO:0051043)3.24989809
41ceramide catabolic process (GO:0046514)3.23024158
42myeloid dendritic cell differentiation (GO:0043011)3.21916062
43neutrophil activation involved in immune response (GO:0002283)3.13806729
44monocyte chemotaxis (GO:0002548)3.13606848
45regulation of interferon-beta biosynthetic process (GO:0045357)3.12281117
46regulation of heterotypic cell-cell adhesion (GO:0034114)3.11437186
47germinal center formation (GO:0002467)3.10685293
48positive regulation of interferon-alpha production (GO:0032727)3.06103095
49NIK/NF-kappaB signaling (GO:0038061)3.06031420
50regulation of cholesterol storage (GO:0010885)3.05681257
51wound healing, spreading of epidermal cells (GO:0035313)3.02457138
52positive regulation of antigen processing and presentation (GO:0002579)3.00734232
53regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.98504351
54positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.98504351
55decidualization (GO:0046697)2.97617368
56interleukin-1-mediated signaling pathway (GO:0070498)2.96265438
57negative regulation of fatty acid transport (GO:2000192)2.93301504
58cellular response to lipopolysaccharide (GO:0071222)2.92019625
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.91490514
60regulation of cell proliferation involved in kidney development (GO:1901722)2.90240113
61regulation of interferon-alpha production (GO:0032647)2.90140593
62positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.88831355
63regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.88831355
64response to protozoan (GO:0001562)2.86806496
65negative regulation of lipid storage (GO:0010888)2.86793143
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85753712
67response to host immune response (GO:0052572)2.85753712
68response to thyroid hormone (GO:0097066)2.85527087
69positive regulation of extracellular matrix organization (GO:1903055)2.83492366
70wound healing, spreading of cells (GO:0044319)2.82166355
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.81235465
72cellular response to molecule of bacterial origin (GO:0071219)2.80407065
73regulation of interleukin-8 biosynthetic process (GO:0045414)2.80405410
74cellular response to arsenic-containing substance (GO:0071243)2.79950995
75regulation of T-helper 2 cell differentiation (GO:0045628)2.78542138
76negative regulation of cytokine production involved in immune response (GO:0002719)2.77183730
77negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77063981
78granulocyte activation (GO:0036230)2.76278051
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75453405
80membrane lipid catabolic process (GO:0046466)2.75143995
81positive regulation of cholesterol efflux (GO:0010875)2.74769277
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72640853
83neutrophil activation (GO:0042119)2.70461075
84superoxide anion generation (GO:0042554)2.70324278
85adhesion of symbiont to host cell (GO:0044650)2.69343981
86virion attachment to host cell (GO:0019062)2.69343981
87endothelial cell chemotaxis (GO:0035767)2.68516577
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67492014
89mitotic cell cycle arrest (GO:0071850)2.67357480
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67077817
91response to host (GO:0075136)2.67077817
92response to host defenses (GO:0052200)2.67077817
93response to progesterone (GO:0032570)2.66814276
94low-density lipoprotein particle clearance (GO:0034383)2.66319457
95osteoclast differentiation (GO:0030316)2.65865569
96activation of MAPKKK activity (GO:0000185)2.65250596
97ovulation from ovarian follicle (GO:0001542)2.64646708
98positive regulation of mRNA catabolic process (GO:0061014)2.62272537
99positive regulation of heat generation (GO:0031652)2.62071085
100positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61323059
101regulation of monocyte differentiation (GO:0045655)2.60521302
102negative regulation of systemic arterial blood pressure (GO:0003085)2.58306780
103type I interferon signaling pathway (GO:0060337)2.57112674
104cellular response to type I interferon (GO:0071357)2.57112674
105ovulation (GO:0030728)2.56979529
106positive regulation of interleukin-6 production (GO:0032755)2.56671505
107immunoglobulin mediated immune response (GO:0016064)2.56358607
108regulation of interleukin-6 production (GO:0032675)2.55876179
109response to type I interferon (GO:0034340)2.55779045
110sphingolipid catabolic process (GO:0030149)2.55003322
111cellular response to biotic stimulus (GO:0071216)2.54050018
112regulation of apoptotic process involved in morphogenesis (GO:1902337)2.53553707
113myeloid dendritic cell activation (GO:0001773)2.52122382
114regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.52059541
115eosinophil chemotaxis (GO:0048245)2.52000169
116defense response to protozoan (GO:0042832)2.51503668
117cytokine secretion (GO:0050663)2.51043011
118regulation of immunoglobulin secretion (GO:0051023)2.50835893
119regulation of type 2 immune response (GO:0002828)2.50770413
120regulation of antigen processing and presentation (GO:0002577)2.50017069
121regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49931802
122regulation of phospholipase A2 activity (GO:0032429)2.49822842
123nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.49123032
124positive regulation of T-helper cell differentiation (GO:0045624)2.48491626
125antigen processing and presentation of endogenous antigen (GO:0019883)2.48132191
126positive regulation of osteoclast differentiation (GO:0045672)2.47507478
127regulation of fever generation (GO:0031620)2.46971320
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46758676
129dendritic cell differentiation (GO:0097028)2.46322787
130amino sugar catabolic process (GO:0046348)2.46055082
131regulation of heat generation (GO:0031650)2.44978463
132positive regulation of astrocyte differentiation (GO:0048711)2.44691905
133regulation of NF-kappaB import into nucleus (GO:0042345)2.44130461
134positive regulation of lipid storage (GO:0010884)2.43883309
135atrioventricular valve morphogenesis (GO:0003181)2.43772556
136regulation of interleukin-12 production (GO:0032655)2.43648323
137hydrogen peroxide biosynthetic process (GO:0050665)2.43186413
138positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.41439007
139regulation of p38MAPK cascade (GO:1900744)2.40876731
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.40643472
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40643472
142purinergic nucleotide receptor signaling pathway (GO:0035590)2.39872808
143myeloid cell activation involved in immune response (GO:0002275)2.39212336
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.37534966
145keratinocyte proliferation (GO:0043616)2.37314916
146positive regulation of interferon-beta production (GO:0032728)2.37247603
147interferon-gamma-mediated signaling pathway (GO:0060333)2.36859524
148regulation of mononuclear cell migration (GO:0071675)2.35583080
149branching involved in labyrinthine layer morphogenesis (GO:0060670)2.34595193
150positive regulation of toll-like receptor signaling pathway (GO:0034123)2.34354419
151positive regulation of interleukin-12 production (GO:0032735)2.33968932
152myeloid leukocyte activation (GO:0002274)2.33361106
153positive regulation of sterol transport (GO:0032373)2.33019659
154positive regulation of cholesterol transport (GO:0032376)2.33019659
155positive regulation of monocyte chemotaxis (GO:0090026)2.32790549
156positive regulation of interleukin-1 beta production (GO:0032731)2.30782888
157cellular response to antibiotic (GO:0071236)2.30333335
158negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30073083
159regulation of podosome assembly (GO:0071801)2.28559664
160negative regulation of protein autophosphorylation (GO:0031953)2.28038561
161positive regulation of chemokine production (GO:0032722)2.27800846
162positive regulation of chemokine biosynthetic process (GO:0045080)2.27766946
163positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.27572400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.56582646
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.06362411
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.47934614
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.81868720
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.51155349
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26132652
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67618986
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.67143505
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65992449
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.64569080
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.56162849
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56077498
13* ESR1_21235772_ChIP-Seq_MCF-7_Human2.49383654
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.47336571
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.36459090
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34967597
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21701970
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.11514880
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01135985
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79998171
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79638620
22* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79089418
23* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79089418
24CLOCK_20551151_ChIP-Seq_293T_Human1.78649065
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78117999
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77938561
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.73622909
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73516486
29CJUN_26792858_Chip-Seq_BT549_Human1.71696597
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71242943
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70139982
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.69863490
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68430286
34RUNX_20019798_ChIP-Seq_JUKART_Human1.64509681
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60854563
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60433584
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.57189519
38VDR_24787735_ChIP-Seq_THP-1_Human1.55055517
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52684113
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52684113
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52684113
42* SOX2_20726797_ChIP-Seq_SW620_Human1.50578030
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48520092
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44878638
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43057199
46P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42116799
47* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40649019
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33252171
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32491933
50* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31705287
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29696726
52KDM2B_26808549_Chip-Seq_K562_Human1.28829384
53VDR_21846776_ChIP-Seq_THP-1_Human1.28414500
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26672021
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.26436434
56GATA1_19941826_ChIP-Seq_K562_Human1.25950549
57SCL_19346495_ChIP-Seq_HPC-7_Human1.24668292
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23727462
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23727462
60* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23196780
61TP53_18474530_ChIP-ChIP_U2OS_Human1.21844660
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.21520755
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21160166
64* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20191106
65RACK7_27058665_Chip-Seq_MCF-7_Human1.19957750
66KDM2B_26808549_Chip-Seq_DND41_Human1.17992299
67* WT1_19549856_ChIP-ChIP_CCG9911_Human1.17125296
68CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16834010
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10144409
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10076182
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09882508
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09260296
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08307672
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07606816
75* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07241844
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06952516
77* LXR_22292898_ChIP-Seq_THP-1_Human1.06523957
78KLF5_25053715_ChIP-Seq_YYC3_Human1.05510088
79* ATF3_27146783_Chip-Seq_COLON_Human1.05388302
80AHR_22903824_ChIP-Seq_MCF-7_Human1.04576500
81* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04018205
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02733250
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01615705
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01034298
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.00763040
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00666683
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99550034
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99527570
89SPI1_23127762_ChIP-Seq_K562_Human0.98323175
90* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97188415
91UBF1/2_26484160_Chip-Seq_HMECs_Human0.96477351
92RUNX1_22412390_ChIP-Seq_EML_Mouse0.96324866
93* PU_27001747_Chip-Seq_BMDM_Mouse0.96261984
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93939056
95* TP63_23658742_ChIP-Seq_EP156T_Human0.93544844
96* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93161111
97VDR_24763502_ChIP-Seq_THP-1_Human0.93161032
98RXR_22108803_ChIP-Seq_LS180_Human0.90561299
99* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89498648
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89189683
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87724551
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86945656
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86864971
104GATA1_22025678_ChIP-Seq_K562_Human0.86655843
105* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86201321
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85876765
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84841776
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.84488810
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.84093677
110TCF7_22412390_ChIP-Seq_EML_Mouse0.83099728
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83009518
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.81850150
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81511454
114* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79131621
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78812038
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78567832
117MYB_26560356_Chip-Seq_TH2_Human0.78114921
118GATA2_19941826_ChIP-Seq_K562_Human0.75430583
119TCF4_18268006_ChIP-ChIP_LS174T_Human0.75171007
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75138767
121* MAF_26560356_Chip-Seq_TH1_Human0.74582453
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.73919305
123AR_21572438_ChIP-Seq_LNCaP_Human0.72293852
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.72173215
125* TP53_16413492_ChIP-PET_HCT116_Human0.72027254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.89847878
2MP0003724_increased_susceptibility_to3.63163886
3MP0002139_abnormal_hepatobiliary_system3.49340641
4MP0003941_abnormal_skin_development3.02647043
5MP0003828_pulmonary_edema2.79927862
6MP0003436_decreased_susceptibility_to2.75604256
7MP0001835_abnormal_antigen_presentation2.55858963
8MP0003303_peritoneal_inflammation2.47130141
9MP0003453_abnormal_keratinocyte_physiol2.38229555
10MP0002148_abnormal_hypersensitivity_rea2.35328219
11MP0001851_eye_inflammation2.35061815
12MP0002877_abnormal_melanocyte_morpholog2.29559059
13MP0004947_skin_inflammation2.25188538
14MP0002419_abnormal_innate_immunity2.10766990
15MP0009278_abnormal_bone_marrow2.08324019
16MP0004381_abnormal_hair_follicle2.07354743
17MP0000383_abnormal_hair_follicle2.04794742
18MP0005000_abnormal_immune_tolerance2.03918988
19MP0006082_CNS_inflammation2.03176860
20MP0009785_altered_susceptibility_to2.03015973
21MP0000604_amyloidosis2.00110642
22MP0003656_abnormal_erythrocyte_physiolo1.97883223
23MP0001346_abnormal_lacrimal_gland1.95348326
24MP0003195_calcinosis1.93387653
25MP0002009_preneoplasia1.92644960
26MP0002060_abnormal_skin_morphology1.92516103
27MP0001853_heart_inflammation1.91242910
28MP0002138_abnormal_hepatobiliary_system1.89312249
29MP0001533_abnormal_skeleton_physiology1.84814713
30MP0002796_impaired_skin_barrier1.84764415
31MP0001790_abnormal_immune_system1.84125352
32MP0005387_immune_system_phenotype1.84125352
33MP0009379_abnormal_foot_pigmentation1.77284717
34MP0005451_abnormal_body_composition1.72804133
35MP0002452_abnormal_antigen_presenting1.67262541
36MP0004510_myositis1.61379435
37MP0003566_abnormal_cell_adhesion1.58123679
38MP0001216_abnormal_epidermal_layer1.57961190
39MP0005025_abnormal_response_to1.57765306
40MP0002098_abnormal_vibrissa_morphology1.57159077
41MP0003300_gastrointestinal_ulcer1.56947118
42MP0003191_abnormal_cellular_cholesterol1.56801591
43* MP0002723_abnormal_immune_serum1.52937300
44MP0010678_abnormal_skin_adnexa1.52060988
45MP0004883_abnormal_blood_vessel1.48656684
46MP0002998_abnormal_bone_remodeling1.46134879
47* MP0001800_abnormal_humoral_immune1.45390345
48* MP0002405_respiratory_system_inflammati1.44276495
49MP0005164_abnormal_response_to1.43854406
50MP0003172_abnormal_lysosome_physiology1.43261363
51MP0004782_abnormal_surfactant_physiolog1.42766764
52MP0003075_altered_response_to1.40946811
53MP0000685_abnormal_immune_system1.38872153
54MP0003448_altered_tumor_morphology1.38344956
55MP0002332_abnormal_exercise_endurance1.37856940
56MP0002277_abnormal_respiratory_mucosa1.37348110
57MP0005671_abnormal_response_to1.36857697
58MP0005023_abnormal_wound_healing1.36122490
59MP0003091_abnormal_cell_migration1.35146826
60MP0001501_abnormal_sleep_pattern1.32833111
61MP0010155_abnormal_intestine_physiology1.31833334
62MP0002006_tumorigenesis1.31747524
63MP0005310_abnormal_salivary_gland1.31430882
64MP0005076_abnormal_cell_differentiation1.29030738
65MP0003329_amyloid_beta_deposits1.25464564
66MP0001819_abnormal_immune_cell1.25365922
67MP0009764_decreased_sensitivity_to1.25083295
68MP0000343_altered_response_to1.24570481
69* MP0002420_abnormal_adaptive_immunity1.22569866
70MP0005390_skeleton_phenotype1.21862380
71MP0001545_abnormal_hematopoietic_system1.21714988
72MP0005397_hematopoietic_system_phenotyp1.21714988
73MP0001845_abnormal_inflammatory_respons1.20614488
74MP0003690_abnormal_glial_cell1.19536550
75MP0000467_abnormal_esophagus_morphology1.16432209
76MP0002166_altered_tumor_susceptibility1.14748153
77MP0005166_decreased_susceptibility_to1.13769231
78MP0004808_abnormal_hematopoietic_stem1.13233451
79MP0005464_abnormal_platelet_physiology1.11168412
80MP0008789_abnormal_olfactory_epithelium1.08951214
81MP0009333_abnormal_splenocyte_physiolog1.07884105
82MP0005058_abnormal_lysosome_morphology1.03420874
83MP0004043_abnormal_pH_regulation1.03275239
84MP0001542_abnormal_bone_strength1.00738694
85MP0005167_abnormal_blood-brain_barrier1.00485391
86MP0001191_abnormal_skin_condition1.00102850
87MP0002090_abnormal_vision0.98115284
88MP0000858_altered_metastatic_potential0.97696833
89MP0010771_integument_phenotype0.96461951
90MP0000762_abnormal_tongue_morphology0.95340339
91MP0005647_abnormal_sex_gland0.94196585
92MP0003950_abnormal_plasma_membrane0.93072592
93MP0000566_synostosis0.92682066
94MP0000372_irregular_coat_pigmentation0.91605432
95MP0008004_abnormal_stomach_pH0.90312217
96MP0008469_abnormal_protein_level0.88055409
97MP0001879_abnormal_lymphatic_vessel0.87349558
98MP0010234_abnormal_vibrissa_follicle0.87028653
99MP0000767_abnormal_smooth_muscle0.86132236
100MP0005257_abnormal_intraocular_pressure0.85090206
101MP0005394_taste/olfaction_phenotype0.84127885
102MP0005499_abnormal_olfactory_system0.84127885
103MP0002933_joint_inflammation0.84038355
104MP0001873_stomach_inflammation0.83842962
105MP0002295_abnormal_pulmonary_circulatio0.82435475
106MP0009840_abnormal_foam_cell0.82218105
107MP0010368_abnormal_lymphatic_system0.82043818
108MP0005388_respiratory_system_phenotype0.82004426
109MP0002133_abnormal_respiratory_system0.82004426
110MP0000647_abnormal_sebaceous_gland0.81601622
111MP0000377_abnormal_hair_follicle0.81122264
112MP0010352_gastrointestinal_tract_polyps0.80280090
113MP0009763_increased_sensitivity_to0.79698116
114MP0005165_increased_susceptibility_to0.79287195
115MP0006054_spinal_hemorrhage0.79016467
116MP0005501_abnormal_skin_physiology0.78554667
117MP0005595_abnormal_vascular_smooth0.78522815
118MP0005365_abnormal_bile_salt0.78494112
119MP0002132_abnormal_respiratory_system0.78425146
120MP0000716_abnormal_immune_system0.78138463
121MP0010307_abnormal_tumor_latency0.77570084
122MP0000249_abnormal_blood_vessel0.77502816
123MP0001727_abnormal_embryo_implantation0.76665391
124MP0005275_abnormal_skin_tensile0.76388625
125MP0003795_abnormal_bone_structure0.74223947
126MP0003879_abnormal_hair_cell0.73428861
127MP0000920_abnormal_myelination0.73422385
128MP0009765_abnormal_xenobiotic_induced0.69573275
129MP0005666_abnormal_adipose_tissue0.66839492
130MP0005375_adipose_tissue_phenotype0.61433130
131MP0003634_abnormal_glial_cell0.60044721
132MP0003806_abnormal_nucleotide_metabolis0.59141663
133MP0003045_fibrosis0.58760288
134MP0003221_abnormal_cardiomyocyte_apopto0.58125523
135MP0008874_decreased_physiological_sensi0.57093353
136MP0002429_abnormal_blood_cell0.55595547
137MP0003646_muscle_fatigue0.55347787

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.04673598
2Stomach cancer (HP:0012126)4.84857836
3Systemic lupus erythematosus (HP:0002725)4.78574957
4Prostate neoplasm (HP:0100787)4.58142099
5Loss of speech (HP:0002371)4.39265859
6Nuclear cataract (HP:0100018)4.18466790
7Thick nail (HP:0001805)4.11294027
8Recurrent abscess formation (HP:0002722)4.07405243
9Neurofibrillary tangles (HP:0002185)4.06222447
10Disinhibition (HP:0000734)4.01348284
11Milia (HP:0001056)3.79694523
12Recurrent bacterial skin infections (HP:0005406)3.74995195
13Lip pit (HP:0100267)3.63734206
14Plantar hyperkeratosis (HP:0007556)3.45906060
15Glomerulonephritis (HP:0000099)3.38572836
16Anhidrosis (HP:0000970)3.34368417
17Orchitis (HP:0100796)3.31797253
18Onycholysis (HP:0001806)3.25462145
19Distal lower limb muscle weakness (HP:0009053)3.15032495
20Axonal loss (HP:0003447)3.10666184
21Increased cerebral lipofuscin (HP:0011813)3.08852832
22Elevated erythrocyte sedimentation rate (HP:0003565)3.04626275
23Myositis (HP:0100614)3.02674465
24Fragile nails (HP:0001808)3.00627869
25Pustule (HP:0200039)2.95801470
26Interstitial pulmonary disease (HP:0006530)2.90159191
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.88700803
28Urethral obstruction (HP:0000796)2.86295513
29Ulnar claw (HP:0001178)2.84893206
30Mutism (HP:0002300)2.83130171
31Retrobulbar optic neuritis (HP:0100654)2.80035558
32Optic neuritis (HP:0100653)2.80035558
33Alopecia of scalp (HP:0002293)2.77411044
34Myocardial infarction (HP:0001658)2.77326162
35Recurrent gram-negative bacterial infections (HP:0005420)2.76878342
36Cerebral inclusion bodies (HP:0100314)2.75735307
37Tetraparesis (HP:0002273)2.74639112
38Abnormality of macrophages (HP:0004311)2.72888700
39Mediastinal lymphadenopathy (HP:0100721)2.72595118
40Abnormality of liposaccharide metabolism (HP:0010968)2.68502351
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.68502351
42Abnormality of glycolipid metabolism (HP:0010969)2.68502351
43Apathy (HP:0000741)2.67295183
44Malnutrition (HP:0004395)2.65792435
45Palmoplantar hyperkeratosis (HP:0000972)2.63994611
46Atrophic scars (HP:0001075)2.63764681
47Segmental peripheral demyelination/remyelination (HP:0003481)2.63693206
48Parakeratosis (HP:0001036)2.61109584
49Hematochezia (HP:0002573)2.58049373
50Premature loss of primary teeth (HP:0006323)2.56527918
51Vacuolated lymphocytes (HP:0001922)2.54849545
52Diminished motivation (HP:0000745)2.52626441
53Osteolytic defects of the hand bones (HP:0009699)2.51069941
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.51069941
55Increased serum ferritin (HP:0003281)2.50954963
56Palmar hyperkeratosis (HP:0010765)2.48627192
57Neuronal loss in central nervous system (HP:0002529)2.46643814
58Alveolar cell carcinoma (HP:0006519)2.46218957
59Nephritis (HP:0000123)2.46060054
60Nausea (HP:0002018)2.45492974
61Amyloidosis (HP:0011034)2.44434846
62Metaphyseal irregularity (HP:0003025)2.41205013
63Gingivitis (HP:0000230)2.39982422
64Absent eyebrow (HP:0002223)2.37894144
65Right ventricular cardiomyopathy (HP:0011663)2.37173501
66Abnormality of the nasal septum (HP:0000419)2.34565612
67Abnormal hemoglobin (HP:0011902)2.33682200
68Neoplasm of the tracheobronchial system (HP:0100552)2.32314533
69Hypotrichosis (HP:0001006)2.31180507
70Abnormality of the distal phalanges of the toes (HP:0010182)2.29203048
71Periodontitis (HP:0000704)2.28859521
72Keratoconjunctivitis sicca (HP:0001097)2.25809938
73Cheilitis (HP:0100825)2.24835615
74Persistence of primary teeth (HP:0006335)2.24632786
75Popliteal pterygium (HP:0009756)2.21439148
76Asymmetric septal hypertrophy (HP:0001670)2.21253375
77Increased CSF protein (HP:0002922)2.20847771
78Recurrent skin infections (HP:0001581)2.17906959
79Recurrent fungal infections (HP:0002841)2.16102409
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15081987
81Dysostosis multiplex (HP:0000943)2.13796435
82Oligodontia (HP:0000677)2.10086591
83Prolonged neonatal jaundice (HP:0006579)2.10051682
84Conical tooth (HP:0000698)2.09611263
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.09533698
86Hyperparathyroidism (HP:0000843)2.08542374
87Vasculitis (HP:0002633)2.07376696
88Gangrene (HP:0100758)2.06893356
89Abnormality of complement system (HP:0005339)2.05977994
90Steatorrhea (HP:0002570)2.05971164
91Natal tooth (HP:0000695)2.04968579
92Purpura (HP:0000979)2.04185102
93Nail dystrophy (HP:0008404)2.00272741
94Pulmonary infiltrates (HP:0002113)2.00135589
95Exocrine pancreatic insufficiency (HP:0001738)1.99986644
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99220652
97Osteomyelitis (HP:0002754)1.98384219
98Xerostomia (HP:0000217)1.98171565
99Stenosis of the external auditory canal (HP:0000402)1.97351381
100Xanthomatosis (HP:0000991)1.97333652
101Stomatitis (HP:0010280)1.97043489
102Inappropriate behavior (HP:0000719)1.95737756
103Keratoconjunctivitis (HP:0001096)1.95574887
104Colitis (HP:0002583)1.94845256
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94360113
106Complement deficiency (HP:0004431)1.94337253
107Urinary glycosaminoglycan excretion (HP:0003541)1.94296257
108Mucopolysacchariduria (HP:0008155)1.94296257
109Bone pain (HP:0002653)1.94171679
110Submucous cleft hard palate (HP:0000176)1.94007107
111Progressive neurologic deterioration (HP:0002344)1.93753271
112Aplasia involving bones of the extremities (HP:0009825)1.93739100
113Aplasia involving bones of the upper limbs (HP:0009823)1.93739100
114Aplasia of the phalanges of the hand (HP:0009802)1.93739100
115Abnormality of the periventricular white matter (HP:0002518)1.93350520
116Obstructive lung disease (HP:0006536)1.93216196
117Chronic obstructive pulmonary disease (HP:0006510)1.93216196
118Increased IgE level (HP:0003212)1.92220383
119Upper limb muscle weakness (HP:0003484)1.92072208
120Peripheral demyelination (HP:0011096)1.90970578
121Hypoplasia of dental enamel (HP:0006297)1.90122172
122Bifid scrotum (HP:0000048)1.89576239
123Cellulitis (HP:0100658)1.89566727
124Arterial tortuosity (HP:0005116)1.89015410
125Abnormality of iron homeostasis (HP:0011031)1.88429206
126Basal ganglia calcification (HP:0002135)1.87717257
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86769422
128Hepatosplenomegaly (HP:0001433)1.85068285
129Cardiomegaly (HP:0001640)1.84980424
130Dementia (HP:0000726)1.81673802
131Abnormality of the prostate (HP:0008775)1.81012909
132Abnormality of polysaccharide metabolism (HP:0011012)1.80781633
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80781633
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80781633
135Arterial thrombosis (HP:0004420)1.80159364
136Asymmetry of the thorax (HP:0001555)1.79835045
137Autoimmune thrombocytopenia (HP:0001973)1.79316258
138Autoimmune hemolytic anemia (HP:0001890)1.78510741
139Protuberant abdomen (HP:0001538)1.76020873
140Polyneuropathy (HP:0001271)1.75031395
141Thin bony cortex (HP:0002753)1.74027759
142Recurrent viral infections (HP:0004429)1.72108724
143Tubulointerstitial fibrosis (HP:0005576)1.68425887
144Thoracic kyphosis (HP:0002942)1.67378822
145Chronic otitis media (HP:0000389)1.66801034
146Vertigo (HP:0002321)1.66690083
147Hemoptysis (HP:0002105)1.65360956
148Esophageal varix (HP:0002040)1.64961986
149Acne (HP:0001061)1.63371029
150Polygenic inheritance (HP:0010982)1.60457644
151Skin nodule (HP:0200036)1.59846978
152Supranuclear gaze palsy (HP:0000605)1.59337443
153Stroke (HP:0001297)1.58652601
154Joint swelling (HP:0001386)1.58281498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.40392282
2MAP3K144.04959896
3MAP3K33.36549467
4TGFBR23.28261764
5MST42.74947156
6TBK12.47877685
7MAP2K22.45821833
8DDR22.42033902
9TYK22.40948434
10IKBKB2.40876661
11NME22.27781700
12IKBKE2.18780057
13EPHA22.17405751
14IRAK32.15818788
15MAP3K22.10966431
16TAOK12.07425193
17GRK71.93875446
18PRPF4B1.75541153
19PIM21.74183144
20EPHB11.72001508
21MST1R1.69017798
22RIPK41.67241546
23CHUK1.65339683
24EPHA31.65303602
25ERN11.62216285
26STK101.61550082
27BMPR21.54484972
28IRAK41.47275845
29LATS21.45256654
30MAPKAPK51.37843876
31PBK1.34967271
32CDC42BPA1.34150967
33JAK11.33776767
34ABL21.32903813
35IRAK21.32844394
36VRK11.28814135
37MAPKAPK31.26213102
38TSSK61.15168761
39EIF2AK21.14936120
40CDK121.14921636
41MAP2K31.11030107
42FGR1.10864246
43MAP3K131.10493688
44TRPM71.09409339
45ERBB31.09100650
46BLK1.00927217
47RPS6KB20.94864230
48PDK20.94377537
49MAP3K110.90783707
50MAP3K10.90579190
51MAPKAPK20.89390062
52CAMK1D0.88914392
53MAPK70.88444963
54CDK30.87873388
55TIE10.86586768
56BMPR1B0.86079843
57MAP4K10.85841847
58FGFR40.83752867
59TXK0.82509395
60TAOK20.81901222
61RIPK10.80527248
62NLK0.77953923
63JAK30.76722009
64IRAK10.74198231
65JAK20.73516161
66NUAK10.73153021
67GSK3A0.72545866
68EPHB20.72039241
69ITK0.70866348
70FER0.70760751
71TEC0.70589106
72FGFR30.70238845
73HCK0.69432856
74SIK10.69112434
75SIK30.67896261
76CSF1R0.67180725
77PTK60.67020279
78MOS0.65935907
79RPS6KA10.62667498
80HIPK20.62396468
81CDK60.62373325
82RPS6KA40.61790681
83DYRK30.61392973
84DMPK0.60829909
85TGFBR10.60508940
86PIM10.60249828
87TAOK30.60185945
88ICK0.58506806
89ZAK0.57638905
90KIT0.54632403
91CSK0.53975160
92ABL10.53894354
93ADRBK20.52759645
94MATK0.51229093
95ZAP700.50448063
96NEK90.50162779
97AKT30.49773672
98NEK60.49768961
99LRRK20.49768793
100RPS6KA60.49153302
101PAK20.49109186
102DAPK30.49067373
103MAP2K10.48425725
104MTOR0.47680153
105PDGFRB0.46807755
106BRD40.46641809
107PDGFRA0.45895268
108GRK10.44429763
109LCK0.43508683
110MAPK40.43178775
111BMX0.43125494
112BTK0.42824141
113RPS6KC10.42580193
114RPS6KL10.42580193
115MARK20.42459670
116RPS6KA50.41187924
117CAMK1G0.40921624
118TYRO30.40119208
119DAPK20.39807247
120RPS6KA20.39565531
121DYRK1B0.38642920
122EIF2AK30.37517759
123MAP3K50.36216177
124STK240.35915747
125MARK30.35788771
126CLK10.35529147
127MAPK30.34353586
128CDK90.33895787
129WEE10.32782392
130PDPK10.31386107
131SGK30.30973430
132TRIB30.28425769
133LYN0.27116887

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85808258
2Osteoclast differentiation_Homo sapiens_hsa043802.57992571
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.44161197
4Staphylococcus aureus infection_Homo sapiens_hsa051502.31298063
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.21834878
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18838866
7Pertussis_Homo sapiens_hsa051332.12467876
8TNF signaling pathway_Homo sapiens_hsa046682.12082772
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.08923374
10Legionellosis_Homo sapiens_hsa051342.06337937
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99696985
12Rheumatoid arthritis_Homo sapiens_hsa053231.97173744
13Malaria_Homo sapiens_hsa051441.87054135
14Toxoplasmosis_Homo sapiens_hsa051451.83024630
15Autoimmune thyroid disease_Homo sapiens_hsa053201.70801377
16Influenza A_Homo sapiens_hsa051641.66555964
17Graft-versus-host disease_Homo sapiens_hsa053321.60520084
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57804857
19B cell receptor signaling pathway_Homo sapiens_hsa046621.56633993
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53599139
21Apoptosis_Homo sapiens_hsa042101.50601802
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46670581
23Tuberculosis_Homo sapiens_hsa051521.46416530
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45253539
25Salmonella infection_Homo sapiens_hsa051321.44892413
26Measles_Homo sapiens_hsa051621.40593829
27Lysosome_Homo sapiens_hsa041421.38771174
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37054743
29Other glycan degradation_Homo sapiens_hsa005111.37039639
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36177354
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34885475
32Hematopoietic cell lineage_Homo sapiens_hsa046401.33466974
33African trypanosomiasis_Homo sapiens_hsa051431.32751261
34Phagosome_Homo sapiens_hsa041451.29673518
35Antigen processing and presentation_Homo sapiens_hsa046121.26724151
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25944854
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22279457
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.19407815
39Hepatitis C_Homo sapiens_hsa051601.18008880
40Prion diseases_Homo sapiens_hsa050201.10367363
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.07297804
42Collecting duct acid secretion_Homo sapiens_hsa049661.07268223
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06976708
44Amoebiasis_Homo sapiens_hsa051461.06103332
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.05070348
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04155205
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01592326
48Herpes simplex infection_Homo sapiens_hsa051681.00948543
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98332894
50Hepatitis B_Homo sapiens_hsa051610.97868912
51Prolactin signaling pathway_Homo sapiens_hsa049170.94408523
52ECM-receptor interaction_Homo sapiens_hsa045120.94383000
53Chemical carcinogenesis_Homo sapiens_hsa052040.93310170
54Allograft rejection_Homo sapiens_hsa053300.92541570
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90425311
56Chemokine signaling pathway_Homo sapiens_hsa040620.90158464
57T cell receptor signaling pathway_Homo sapiens_hsa046600.87852146
58Complement and coagulation cascades_Homo sapiens_hsa046100.86029237
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85904372
60Shigellosis_Homo sapiens_hsa051310.84392007
61Adherens junction_Homo sapiens_hsa045200.83843111
62Asthma_Homo sapiens_hsa053100.81640245
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.78895112
64Small cell lung cancer_Homo sapiens_hsa052220.72996751
65Circadian rhythm_Homo sapiens_hsa047100.72355487
66Mineral absorption_Homo sapiens_hsa049780.71677549
67Proteoglycans in cancer_Homo sapiens_hsa052050.69886920
68Chronic myeloid leukemia_Homo sapiens_hsa052200.67928601
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.67487159
70Prostate cancer_Homo sapiens_hsa052150.65482157
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65223494
72MAPK signaling pathway_Homo sapiens_hsa040100.65107769
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64281385
74Sphingolipid metabolism_Homo sapiens_hsa006000.64195395
75Caffeine metabolism_Homo sapiens_hsa002320.63741499
76Acute myeloid leukemia_Homo sapiens_hsa052210.63137748
77TGF-beta signaling pathway_Homo sapiens_hsa043500.60267910
78* HTLV-I infection_Homo sapiens_hsa051660.58780455
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.58450462
80Notch signaling pathway_Homo sapiens_hsa043300.57341649
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55593626
82Arachidonic acid metabolism_Homo sapiens_hsa005900.52694646
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51472883
84FoxO signaling pathway_Homo sapiens_hsa040680.51373479
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50410947
86Epstein-Barr virus infection_Homo sapiens_hsa051690.49620601
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.49569936
88Type II diabetes mellitus_Homo sapiens_hsa049300.49220724
89Renal cell carcinoma_Homo sapiens_hsa052110.49122215
90Focal adhesion_Homo sapiens_hsa045100.48383073
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48271186
92Platelet activation_Homo sapiens_hsa046110.47345544
93Vibrio cholerae infection_Homo sapiens_hsa051100.47135024
94PPAR signaling pathway_Homo sapiens_hsa033200.46724861
95Insulin resistance_Homo sapiens_hsa049310.46674419
96Viral myocarditis_Homo sapiens_hsa054160.44632860
97Dorso-ventral axis formation_Homo sapiens_hsa043200.43647676
98HIF-1 signaling pathway_Homo sapiens_hsa040660.43012122
99Bladder cancer_Homo sapiens_hsa052190.42685905
100Retinol metabolism_Homo sapiens_hsa008300.42386700
101Pancreatic cancer_Homo sapiens_hsa052120.42148479
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41866559
103Sulfur metabolism_Homo sapiens_hsa009200.41810000
104Type I diabetes mellitus_Homo sapiens_hsa049400.40877521
105MicroRNAs in cancer_Homo sapiens_hsa052060.40045924
106Pathways in cancer_Homo sapiens_hsa052000.38997731
107Tryptophan metabolism_Homo sapiens_hsa003800.38644887
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38280666
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37410859
110GnRH signaling pathway_Homo sapiens_hsa049120.37187171
111VEGF signaling pathway_Homo sapiens_hsa043700.36340168
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36232143
113Estrogen signaling pathway_Homo sapiens_hsa049150.34771188
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.34723516
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34032280
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31978776
117Galactose metabolism_Homo sapiens_hsa000520.29927151
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26633462
119Viral carcinogenesis_Homo sapiens_hsa052030.24193399
120Fructose and mannose metabolism_Homo sapiens_hsa000510.24186854
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22641463
122ErbB signaling pathway_Homo sapiens_hsa040120.19759269

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