ATF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.04035876
2Golgi transport vesicle coating (GO:0048200)5.31261325
3COPI coating of Golgi vesicle (GO:0048205)5.31261325
4folic acid-containing compound biosynthetic process (GO:0009396)4.49937816
5L-serine metabolic process (GO:0006563)4.43823663
6mitotic chromosome condensation (GO:0007076)4.19371906
7proline biosynthetic process (GO:0006561)4.11590311
8regulation of mammary gland epithelial cell proliferation (GO:0033599)4.10210892
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.04899973
10regulation of translational fidelity (GO:0006450)3.92146585
11* positive regulation of nuclease activity (GO:0032075)3.89737218
12negative regulation of erythrocyte differentiation (GO:0045647)3.89357697
13* activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.88921953
14cellular protein complex disassembly (GO:0043624)3.81186283
15ribonucleoprotein complex biogenesis (GO:0022613)3.72948414
16spliceosomal tri-snRNP complex assembly (GO:0000244)3.66970393
17* regulation of nuclease activity (GO:0032069)3.65737696
18protein complex disassembly (GO:0043241)3.60956755
19* endoplasmic reticulum unfolded protein response (GO:0030968)3.60179067
20* cellular response to unfolded protein (GO:0034620)3.47136183
21dosage compensation (GO:0007549)3.41090071
22protein retention in ER lumen (GO:0006621)3.39888057
23macromolecular complex disassembly (GO:0032984)3.32071784
24formation of translation preinitiation complex (GO:0001731)3.29333098
25regulation of RNA export from nucleus (GO:0046831)3.27226153
26serine family amino acid biosynthetic process (GO:0009070)3.24278803
27* cellular response to topologically incorrect protein (GO:0035967)3.23287839
28protein localization to endosome (GO:0036010)3.22536090
29* ER-nucleus signaling pathway (GO:0006984)3.22517523
30cellular protein complex localization (GO:0034629)3.19852006
31activation of MAPKKK activity (GO:0000185)3.19809021
32adherens junction assembly (GO:0034333)3.16580096
33protein complex localization (GO:0031503)3.12498109
34focal adhesion assembly (GO:0048041)3.11834294
35cell-substrate adherens junction assembly (GO:0007045)3.11834294
36ribosome biogenesis (GO:0042254)3.03631263
37positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.99253310
38apoptotic process involved in morphogenesis (GO:0060561)2.98559321
39protein targeting to membrane (GO:0006612)2.98289808
40regulation of NFAT protein import into nucleus (GO:0051532)2.95069359
41protein localization to kinetochore (GO:0034501)2.94238146
42planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93921086
43regulation of nucleobase-containing compound transport (GO:0032239)2.89752139
44heterochromatin organization (GO:0070828)2.87969961
45* response to endoplasmic reticulum stress (GO:0034976)2.85404947
46nuclear pore organization (GO:0006999)2.83146668
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83004012
48regulation of glucose import in response to insulin stimulus (GO:2001273)2.82054126
49COPII vesicle coating (GO:0048208)2.80498096
503-UTR-mediated mRNA stabilization (GO:0070935)2.77655579
51mitochondrial fusion (GO:0008053)2.77651971
52nuclear pore complex assembly (GO:0051292)2.76285415
53viral transcription (GO:0019083)2.76180393
54translational termination (GO:0006415)2.75988453
55translational initiation (GO:0006413)2.74459299
56protein targeting to ER (GO:0045047)2.74111792
57proline metabolic process (GO:0006560)2.74075622
58mitotic nuclear envelope disassembly (GO:0007077)2.73896686
59skin morphogenesis (GO:0043589)2.72156440
60negative regulation of fatty acid transport (GO:2000192)2.71944479
61DNA unwinding involved in DNA replication (GO:0006268)2.70978046
62mitochondrial DNA metabolic process (GO:0032042)2.70894123
63nuclear envelope disassembly (GO:0051081)2.70676482
64membrane disassembly (GO:0030397)2.70676482
65regulation of translational termination (GO:0006449)2.70633431
66regulation of interleukin-12 biosynthetic process (GO:0045075)2.70030042
67L-alpha-amino acid transmembrane transport (GO:1902475)2.68447314
68negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68396970
69tetrahydrofolate metabolic process (GO:0046653)2.66592050
70regulation of histone H3-K27 methylation (GO:0061085)2.65804233
71protein maturation by protein folding (GO:0022417)2.65697763
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65444620
73cotranslational protein targeting to membrane (GO:0006613)2.65391022
74peptidyl-arginine omega-N-methylation (GO:0035247)2.65390196
75* response to unfolded protein (GO:0006986)2.64982106
76ribosomal small subunit assembly (GO:0000028)2.64681046
77* intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.64586181
78T cell apoptotic process (GO:0070231)2.64442658
79trophoblast giant cell differentiation (GO:0060707)2.63024771
80establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62844080
81maternal placenta development (GO:0001893)2.62532220
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62376553
83nuclear-transcribed mRNA catabolic process (GO:0000956)2.61578128
84RNA stabilization (GO:0043489)2.60716340
85mRNA stabilization (GO:0048255)2.60716340
86negative regulation of glycogen biosynthetic process (GO:0045719)2.59526966
87translational elongation (GO:0006414)2.59201559
88retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57256803
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57086931
90negative regulation of histone methylation (GO:0031061)2.55183263
91mRNA catabolic process (GO:0006402)2.54813638
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.54684008
93interferon-gamma secretion (GO:0072643)2.54080589
94IMP biosynthetic process (GO:0006188)2.54029925
95pinocytosis (GO:0006907)2.54017797
96trophectodermal cell differentiation (GO:0001829)2.53781125
97mannose metabolic process (GO:0006013)2.53120130
98protein export from nucleus (GO:0006611)2.51753964
99cellular response to glucose starvation (GO:0042149)2.50204473
100positive regulation of p38MAPK cascade (GO:1900745)2.49904625
101histone H2B ubiquitination (GO:0033523)2.49748934
102protein localization to chromosome, centromeric region (GO:0071459)2.48366751
103intestinal epithelial cell development (GO:0060576)2.48017707
104regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.47676442
105positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.47676442
106* response to topologically incorrect protein (GO:0035966)2.47089786
107chromosome condensation (GO:0030261)2.46314789
108DNA topological change (GO:0006265)2.44774188
109protein localization to endoplasmic reticulum (GO:0070972)2.44319813
110maturation of SSU-rRNA (GO:0030490)2.43500665
111stress fiber assembly (GO:0043149)2.43041501
112cellular hyperosmotic response (GO:0071474)2.41498870
113negative regulation of RNA splicing (GO:0033119)2.41117022
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.38944709
1154-hydroxyproline metabolic process (GO:0019471)2.37509618
116regulation of SMAD protein import into nucleus (GO:0060390)2.36538909
117regulation of translational elongation (GO:0006448)2.35333949
118tRNA aminoacylation for protein translation (GO:0006418)2.35058164
119positive regulation of SMAD protein import into nucleus (GO:0060391)2.33903102
120ribosome assembly (GO:0042255)2.33320066
121decidualization (GO:0046697)2.33204962
122negative regulation of translational initiation (GO:0045947)2.31370581
123protein hydroxylation (GO:0018126)2.30504603
124regulation of early endosome to late endosome transport (GO:2000641)2.29911506
125regulation of vitamin D biosynthetic process (GO:0060556)2.29074960
126viral life cycle (GO:0019058)2.28651360
127sequestering of metal ion (GO:0051238)2.27244202
128response to UV-C (GO:0010225)2.26218914
129nuclear envelope organization (GO:0006998)2.26190511
130pteridine-containing compound biosynthetic process (GO:0042559)2.25222555
131peptidyl-proline hydroxylation (GO:0019511)2.24776321
132positive regulation of histone deacetylation (GO:0031065)2.23146170
133vesicle coating (GO:0006901)2.23082022
134histone-serine phosphorylation (GO:0035404)2.22133847
135embryonic process involved in female pregnancy (GO:0060136)2.21886767
136amino acid activation (GO:0043038)2.21816023
137tRNA aminoacylation (GO:0043039)2.21816023
138myeloid cell homeostasis (GO:0002262)2.17084427
139regulation of hippo signaling (GO:0035330)2.16503249
140negative regulation of mRNA metabolic process (GO:1903312)2.16042694
141histone H2A monoubiquitination (GO:0035518)2.15450365
142hepatocyte apoptotic process (GO:0097284)2.14940838
143pore complex assembly (GO:0046931)2.14825644
144lymphocyte apoptotic process (GO:0070227)2.14574926
145ribosomal large subunit biogenesis (GO:0042273)2.14559351
146exocrine pancreas development (GO:0031017)2.14379851
147regulation of chromatin binding (GO:0035561)2.13823418
148response to laminar fluid shear stress (GO:0034616)2.13430931
149negative regulation of mRNA processing (GO:0050686)2.11326703
150folic acid-containing compound metabolic process (GO:0006760)2.10309990
151regulation of protein heterodimerization activity (GO:0043497)2.09118819
152regulation of spindle organization (GO:0090224)2.09110517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20373318
2* EGR1_19374776_ChIP-ChIP_THP-1_Human3.97264047
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.52546812
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03674631
5* MYC_18555785_ChIP-Seq_MESCs_Mouse2.95831859
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.92431626
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90193516
8MYC_22102868_ChIP-Seq_BL_Human2.79986378
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54183109
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47111905
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22357334
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00645400
13LXR_22292898_ChIP-Seq_THP-1_Human1.94002127
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90905823
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88125354
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82798125
17ATF3_27146783_Chip-Seq_COLON_Human1.82355600
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81535886
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80300107
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79159719
21* CLOCK_20551151_ChIP-Seq_293T_Human1.77904668
22* XRN2_22483619_ChIP-Seq_HELA_Human1.76829174
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74839875
24* VDR_21846776_ChIP-Seq_THP-1_Human1.71457059
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70561085
26* TFEB_21752829_ChIP-Seq_HELA_Human1.67135849
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.65877170
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64583494
29* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64298479
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59552872
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55128851
32ZNF263_19887448_ChIP-Seq_K562_Human1.54203669
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51868632
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.51133194
35* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50721625
36* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50308376
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48669170
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46149268
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41714492
40ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38242576
41KDM2B_26808549_Chip-Seq_K562_Human1.37248262
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36994285
43* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35764713
44DCP1A_22483619_ChIP-Seq_HELA_Human1.35620286
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.34975135
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34933738
47* TCF7_22412390_ChIP-Seq_EML_Mouse1.33901468
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33522274
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32794411
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31994290
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31527966
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31274369
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31079372
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29919484
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29381421
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.27946261
57TTF2_22483619_ChIP-Seq_HELA_Human1.27798465
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25974705
59* MAF_26560356_Chip-Seq_TH1_Human1.24924140
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24712256
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24574628
62CIITA_25753668_ChIP-Seq_RAJI_Human1.24197847
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24181697
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23943010
65* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23826273
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23782851
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23648466
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.23347577
69* KDM5A_27292631_Chip-Seq_BREAST_Human1.23168643
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22389874
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22063497
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21719250
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21594754
74AR_21909140_ChIP-Seq_LNCAP_Human1.21414990
75* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21323271
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.20969773
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.20305880
78* VDR_23849224_ChIP-Seq_CD4+_Human1.20282792
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19472591
80CREB1_26743006_Chip-Seq_LNCaP_Human1.18330174
81* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17525786
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16815442
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16794980
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16039075
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15914279
86* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15659908
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15328178
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14851348
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14622541
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.13966177
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13931118
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13149178
93* UTX_26944678_Chip-Seq_JUKART_Human1.12860810
94GABP_19822575_ChIP-Seq_HepG2_Human1.12437509
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12295605
96KDM2B_26808549_Chip-Seq_DND41_Human1.11797831
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11448232
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11282026
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.10942278
100* VDR_24763502_ChIP-Seq_THP-1_Human1.10620797
101* RACK7_27058665_Chip-Seq_MCF-7_Human1.10279977
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09978627
103* MAF_26560356_Chip-Seq_TH2_Human1.09710012
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09678502
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.08441312
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08089460
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.07703329
108* CHD1_26751641_Chip-Seq_LNCaP_Human1.07621076
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07130484
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07130484
111* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06310782
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05673584
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05548685
114NCOR1_26117541_ChIP-Seq_K562_Human1.05294677
115ELK1_19687146_ChIP-ChIP_HELA_Human1.05265102
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04358553
117GATA6_25053715_ChIP-Seq_YYC3_Human1.04204450
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04045823
119P68_20966046_ChIP-Seq_HELA_Human1.04020683
120ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03709846
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03508486
122SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03367939
123UBF1/2_26484160_Chip-Seq_HMECs_Human1.02971210
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02638473
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02082378
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01577130
127TP53_22127205_ChIP-Seq_IMR90_Human1.01557496
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01485482
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00835673
130SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00028625
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00018820
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00018820
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00018820
134MYB_26560356_Chip-Seq_TH2_Human0.99803221
135* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98675943
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97657129
137TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96406639
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.95964713
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95529846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.14225789
2MP0002877_abnormal_melanocyte_morpholog3.07836043
3MP0003693_abnormal_embryo_hatching3.06240910
4MP0003705_abnormal_hypodermis_morpholog2.95421945
5MP0005076_abnormal_cell_differentiation2.59642185
6MP0004233_abnormal_muscle_weight2.45296249
7MP0003566_abnormal_cell_adhesion2.20542225
8MP0003300_gastrointestinal_ulcer2.19399796
9MP0004957_abnormal_blastocyst_morpholog2.16438114
10MP0005451_abnormal_body_composition2.14955342
11MP0008438_abnormal_cutaneous_collagen2.04123799
12MP0005623_abnormal_meninges_morphology1.98157225
13MP0005666_abnormal_adipose_tissue1.93179601
14MP0010307_abnormal_tumor_latency1.92415923
15MP0006054_spinal_hemorrhage1.91270910
16MP0000003_abnormal_adipose_tissue1.85432795
17MP0009379_abnormal_foot_pigmentation1.83041469
18MP0005375_adipose_tissue_phenotype1.80043693
19MP0004858_abnormal_nervous_system1.78897453
20MP0003077_abnormal_cell_cycle1.77932345
21MP0003303_peritoneal_inflammation1.72077710
22MP0005275_abnormal_skin_tensile1.70608453
23MP0005257_abnormal_intraocular_pressure1.70148145
24MP0003111_abnormal_nucleus_morphology1.66538753
25MP0003436_decreased_susceptibility_to1.64135930
26MP0009840_abnormal_foam_cell1.59856331
27MP0008007_abnormal_cellular_replicative1.58353524
28MP0010234_abnormal_vibrissa_follicle1.57554006
29MP0005023_abnormal_wound_healing1.56062189
30MP0001849_ear_inflammation1.53984517
31MP0003283_abnormal_digestive_organ1.53838570
32MP0008260_abnormal_autophagy1.53570054
33MP0001348_abnormal_lacrimal_gland1.49233699
34* MP0000350_abnormal_cell_proliferation1.45067006
35MP0000858_altered_metastatic_potential1.44372500
36MP0000733_abnormal_muscle_development1.43963348
37MP0010030_abnormal_orbit_morphology1.39645125
38MP0000490_abnormal_crypts_of1.36199825
39MP0002249_abnormal_larynx_morphology1.34475922
40MP0001730_embryonic_growth_arrest1.34365932
41MP0004808_abnormal_hematopoietic_stem1.30215757
42MP0009278_abnormal_bone_marrow1.29449354
43MP0003123_paternal_imprinting1.27616079
44MP0002089_abnormal_postnatal_growth/wei1.27585881
45MP0001346_abnormal_lacrimal_gland1.27490883
46MP0002060_abnormal_skin_morphology1.23897147
47MP0004264_abnormal_extraembryonic_tissu1.23390414
48MP0009333_abnormal_splenocyte_physiolog1.23231441
49MP0003315_abnormal_perineum_morphology1.21753484
50MP0004947_skin_inflammation1.20606680
51MP0004272_abnormal_basement_membrane1.20115637
52* MP0004197_abnormal_fetal_growth/weight/1.18930401
53MP0000759_abnormal_skeletal_muscle1.15926723
54MP0000750_abnormal_muscle_regeneration1.14375034
55MP0003453_abnormal_keratinocyte_physiol1.13875423
56MP0000537_abnormal_urethra_morphology1.13249383
57MP0003942_abnormal_urinary_system1.11750884
58MP0002086_abnormal_extraembryonic_tissu1.11423665
59MP0010094_abnormal_chromosome_stability1.11288137
60MP0001533_abnormal_skeleton_physiology1.10203511
61MP0003221_abnormal_cardiomyocyte_apopto1.09883073
62MP0005503_abnormal_tendon_morphology1.09745039
63MP0001672_abnormal_embryogenesis/_devel1.09570595
64MP0005380_embryogenesis_phenotype1.09570595
65MP0002088_abnormal_embryonic_growth/wei1.08468875
66MP0003984_embryonic_growth_retardation1.08366421
67MP0003448_altered_tumor_morphology1.08190736
68MP0001697_abnormal_embryo_size1.07879676
69MP0002009_preneoplasia1.07288901
70MP0000747_muscle_weakness1.05641156
71MP0004087_abnormal_muscle_fiber1.04178373
72MP0010630_abnormal_cardiac_muscle1.03439045
73MP0008961_abnormal_basal_metabolism1.03195611
74MP0002080_prenatal_lethality0.99937168
75MP0000678_abnormal_parathyroid_gland0.99726010
76* MP0002896_abnormal_bone_mineralization0.98312666
77MP0008932_abnormal_embryonic_tissue0.97936477
78MP0005390_skeleton_phenotype0.97884574
79MP0002396_abnormal_hematopoietic_system0.97820575
80MP0009053_abnormal_anal_canal0.96296886
81* MP0005220_abnormal_exocrine_pancreas0.95178507
82MP0002933_joint_inflammation0.94377693
83MP0003091_abnormal_cell_migration0.93997437
84MP0002084_abnormal_developmental_patter0.93426905
85MP0005501_abnormal_skin_physiology0.93151284
86MP0005508_abnormal_skeleton_morphology0.93003095
87MP0004185_abnormal_adipocyte_glucose0.92741952
88MP0002085_abnormal_embryonic_tissue0.92450817
89MP0005409_darkened_coat_color0.91886331
90* MP0001944_abnormal_pancreas_morphology0.91675837
91MP0000762_abnormal_tongue_morphology0.91202948
92MP0002405_respiratory_system_inflammati0.90980162
93MP0001243_abnormal_dermal_layer0.90892574
94MP0002019_abnormal_tumor_incidence0.90325910
95MP0003115_abnormal_respiratory_system0.88899409
96MP0000566_synostosis0.88269451
97MP0000516_abnormal_urinary_system0.88064435
98MP0005367_renal/urinary_system_phenotyp0.88064435
99MP0008057_abnormal_DNA_replication0.86644217
100MP0005384_cellular_phenotype0.85389558
101MP0001915_intracranial_hemorrhage0.84543913
102* MP0003795_abnormal_bone_structure0.84511847
103* MP0002693_abnormal_pancreas_physiology0.84434018
104MP0003119_abnormal_digestive_system0.84217774
105MP0001216_abnormal_epidermal_layer0.82440391
106MP0000477_abnormal_intestine_morphology0.82011514
107MP0010155_abnormal_intestine_physiology0.81995894
108MP0001661_extended_life_span0.80370481
109MP0000313_abnormal_cell_death0.80051624
110MP0003279_aneurysm0.79870770
111MP0003656_abnormal_erythrocyte_physiolo0.79613100
112MP0005621_abnormal_cell_physiology0.79488560
113MP0002234_abnormal_pharynx_morphology0.77864646
114MP0001881_abnormal_mammary_gland0.77805245
115* MP0002697_abnormal_eye_size0.77740522
116MP0009672_abnormal_birth_weight0.76530911
117MP0009703_decreased_birth_body0.76474212
118MP0004782_abnormal_surfactant_physiolog0.76034669
119MP0002092_abnormal_eye_morphology0.75696335
120MP0002998_abnormal_bone_remodeling0.75321383
121MP0005058_abnormal_lysosome_morphology0.74121512
122MP0002111_abnormal_tail_morphology0.73839394
123MP0000371_diluted_coat_color0.73787651
124MP0001727_abnormal_embryo_implantation0.73726648
125MP0003959_abnormal_lean_body0.73089653
126MP0005000_abnormal_immune_tolerance0.72995915
127MP0000767_abnormal_smooth_muscle0.72979858
128MP0001545_abnormal_hematopoietic_system0.72825673
129MP0005397_hematopoietic_system_phenotyp0.72825673
130* MP0002113_abnormal_skeleton_development0.71897490
131MP0009931_abnormal_skin_appearance0.71814989
132MP0002970_abnormal_white_adipose0.70699998
133MP0003890_abnormal_embryonic-extraembry0.70676186
134* MP0002398_abnormal_bone_marrow0.70623237
135MP0002452_abnormal_antigen_presenting0.70402327
136MP0002796_impaired_skin_barrier0.70097689
137MP0000703_abnormal_thymus_morphology0.69336081
138MP0008058_abnormal_DNA_repair0.68939115
139MP0002925_abnormal_cardiovascular_devel0.68220240
140MP0000428_abnormal_craniofacial_morphol0.68061673

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)3.53980379
2Hyperacusis (HP:0010780)3.43119277
3Protrusio acetabuli (HP:0003179)3.28266273
4Progressive muscle weakness (HP:0003323)3.22396649
5Reticulocytopenia (HP:0001896)3.09179656
6Degeneration of anterior horn cells (HP:0002398)2.85759190
7Abnormality of the anterior horn cell (HP:0006802)2.85759190
8Long palpebral fissure (HP:0000637)2.75721639
9Achilles tendon contracture (HP:0001771)2.75422350
10Increased density of long bones (HP:0006392)2.75264866
11Thoracolumbar scoliosis (HP:0002944)2.68545638
12Premature rupture of membranes (HP:0001788)2.65960256
13Insomnia (HP:0100785)2.63528406
14Deep palmar crease (HP:0006191)2.56362023
15Metaphyseal cupping (HP:0003021)2.54837307
16Abnormality of the Achilles tendon (HP:0005109)2.53995742
17Hand muscle atrophy (HP:0009130)2.52648532
18Genu recurvatum (HP:0002816)2.47604849
19Distal lower limb amyotrophy (HP:0008944)2.42747973
20Progressive external ophthalmoplegia (HP:0000590)2.42299713
21Thin bony cortex (HP:0002753)2.37721307
22Abnormality of the calcaneus (HP:0008364)2.36732159
23Cerebral aneurysm (HP:0004944)2.36043810
24Disproportionate tall stature (HP:0001519)2.35754729
25Deformed tarsal bones (HP:0008119)2.32821983
26Dysmetric saccades (HP:0000641)2.32649238
27Ankle contracture (HP:0006466)2.31485540
28Ulnar deviation of the wrist (HP:0003049)2.30499429
29Trismus (HP:0000211)2.27525376
30Centrally nucleated skeletal muscle fibers (HP:0003687)2.27289148
31Abnormality of reticulocytes (HP:0004312)2.25107311
32Macrocytic anemia (HP:0001972)2.24866817
33Flat acetabular roof (HP:0003180)2.23614939
34Persistence of primary teeth (HP:0006335)2.23054555
35Myopathic facies (HP:0002058)2.21414550
36Mucopolysacchariduria (HP:0008155)2.16760566
37Urinary glycosaminoglycan excretion (HP:0003541)2.16760566
38Syringomyelia (HP:0003396)2.16502513
39Mitral regurgitation (HP:0001653)2.13663436
40Severe short stature (HP:0003510)2.12803134
41Distal upper limb amyotrophy (HP:0007149)2.11028582
42Upper limb amyotrophy (HP:0009129)2.11028582
43Ragged-red muscle fibers (HP:0003200)2.09707771
44Vertebral compression fractures (HP:0002953)2.09526891
45Sparse lateral eyebrow (HP:0005338)2.08962793
46Dilatation of the ascending aorta (HP:0005111)2.06324836
47Multiple enchondromatosis (HP:0005701)2.06080163
48Carpal bone hypoplasia (HP:0001498)2.05350476
49Abnormality of the distal phalanges of the toes (HP:0010182)2.03878822
50Aortic aneurysm (HP:0004942)2.03531585
51Septate vagina (HP:0001153)2.02903603
52Asymmetry of the thorax (HP:0001555)2.02134300
53Fatigue (HP:0012378)2.01107531
54Abnormality of the thoracic spine (HP:0100711)2.01053167
55Turricephaly (HP:0000262)2.00141592
56Peritonitis (HP:0002586)1.99030560
57Small epiphyses (HP:0010585)1.98984091
58Increased connective tissue (HP:0009025)1.98733222
59Renal duplication (HP:0000075)1.98601846
60Abnormality of the umbilical cord (HP:0010881)1.97111805
61Epiphyseal dysplasia (HP:0002656)1.96530769
62Biconcave vertebral bodies (HP:0004586)1.95366838
63Interstitial pulmonary disease (HP:0006530)1.94565602
64Hyperparathyroidism (HP:0000843)1.93716745
65Abnormal foot bone ossification (HP:0010675)1.92788205
66Truncus arteriosus (HP:0001660)1.92608314
67Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92381940
68Eczematoid dermatitis (HP:0000976)1.92234291
69Ulnar bowing (HP:0003031)1.91986388
70Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91438199
71Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91438199
72Abnormality of polysaccharide metabolism (HP:0011012)1.91438199
73Shallow orbits (HP:0000586)1.91158088
74Overriding aorta (HP:0002623)1.90888053
75Joint stiffness (HP:0001387)1.90838853
76Spinal cord compression (HP:0002176)1.90356033
77Breast hypoplasia (HP:0003187)1.89975715
78Abnormality of the acetabulum (HP:0003170)1.89956038
79Pseudobulbar signs (HP:0002200)1.89677788
80Ankyloglossia (HP:0010296)1.88627416
81Mitral valve prolapse (HP:0001634)1.87606732
82Dysostosis multiplex (HP:0000943)1.87484797
83Increased variability in muscle fiber diameter (HP:0003557)1.87322948
84Abnormal number of erythroid precursors (HP:0012131)1.86944614
85Cupped ribs (HP:0000887)1.86596111
86Wormian bones (HP:0002645)1.86207572
87Hammertoe (HP:0001765)1.86025527
88Cortical dysplasia (HP:0002539)1.85458494
89Reticulocytosis (HP:0001923)1.85283569
90Deviation of the thumb (HP:0009603)1.84383744
91Flattened epiphyses (HP:0003071)1.83737263
92Vertebral clefting (HP:0008428)1.82325258
93Abnormality of skeletal muscle fiber size (HP:0012084)1.81939840
94Premature skin wrinkling (HP:0100678)1.80942309
95Transposition of the great arteries (HP:0001669)1.80675194
96Abnormal connection of the cardiac segments (HP:0011545)1.80675194
97Abnormal ventriculo-arterial connection (HP:0011563)1.80675194
98Exostoses (HP:0100777)1.80387678
99Back pain (HP:0003418)1.80128383
100Atrophic scars (HP:0001075)1.79052721
101Platyspondyly (HP:0000926)1.78042805
102Glossoptosis (HP:0000162)1.77203253
103Lower limb amyotrophy (HP:0007210)1.76764121
104Elfin facies (HP:0004428)1.76092647
105Pointed chin (HP:0000307)1.74750836
106Abnormality of the distal phalanx of the thumb (HP:0009617)1.74365788
107Pterygium (HP:0001059)1.74237679
108Increased nuchal translucency (HP:0010880)1.73092059
109Broad face (HP:0000283)1.72059855
110Spinal rigidity (HP:0003306)1.71686860
111Abnormality of the phalanges of the hallux (HP:0010057)1.71485402
112Thoracic kyphosis (HP:0002942)1.70285165
113Vertebral hypoplasia (HP:0008417)1.70038778
114Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70038778
115Patellar dislocation (HP:0002999)1.70001762
116Rectal prolapse (HP:0002035)1.69226578
117Broad distal phalanx of finger (HP:0009836)1.69165316
118Thrombocytosis (HP:0001894)1.69130514
119Malignant gastrointestinal tract tumors (HP:0006749)1.69042772
120Gastrointestinal carcinoma (HP:0002672)1.69042772
121Biliary tract neoplasm (HP:0100574)1.68257247
122Delayed epiphyseal ossification (HP:0002663)1.68145175
123Aneurysm (HP:0002617)1.68093097
124Hypercortisolism (HP:0001578)1.67931433
125Proximal placement of thumb (HP:0009623)1.67877689
126Abnormal gallbladder physiology (HP:0012438)1.67671404
127Cholecystitis (HP:0001082)1.67671404
128Microvesicular hepatic steatosis (HP:0001414)1.66862012
129Tibial bowing (HP:0002982)1.66702102
130Osteolytic defects of the hand bones (HP:0009699)1.65458463
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.65458463
132Abnormality of the odontoid process (HP:0003310)1.64332915
133Pallor (HP:0000980)1.63745118
134Flat capital femoral epiphysis (HP:0003370)1.62434232
135Neonatal short-limb short stature (HP:0008921)1.62190798
136Subacute progressive viral hepatitis (HP:0006572)1.62090459
137Spinal muscular atrophy (HP:0007269)1.61897347
138Squamous cell carcinoma (HP:0002860)1.61700149
139Hyperthyroidism (HP:0000836)1.61695557
140Beaking of vertebral bodies (HP:0004568)1.61662623
141Selective tooth agenesis (HP:0001592)1.61144871
142Abnormality of the tricuspid valve (HP:0001702)1.59721571
143Hypertensive crisis (HP:0100735)1.59696891
144Thin ribs (HP:0000883)1.59345782
145Vertebral arch anomaly (HP:0008438)1.59268618
146Hypercalcemia (HP:0003072)1.59234931
147Pelvic girdle muscle weakness (HP:0003749)1.58804201
148Exercise-induced myalgia (HP:0003738)1.58193398
149Overlapping toe (HP:0001845)1.58144245
150Radial bowing (HP:0002986)1.57998207
151Hypoplasia of the odontoid process (HP:0003311)1.57790919
152Bladder diverticulum (HP:0000015)1.57755236
153Large hands (HP:0001176)1.57693614
154Polygenic inheritance (HP:0010982)1.57555635
155Irregular epiphyses (HP:0010582)1.57134751
156Upper limb muscle weakness (HP:0003484)1.56977573
157Hypoplastic ischia (HP:0003175)1.55137530
158Calcaneovalgus deformity (HP:0001848)1.54751621
159Slender long bone (HP:0003100)1.53827271
160Abnormal tarsal ossification (HP:0008369)1.52489205
161Abnormal vertebral ossification (HP:0100569)1.51278201
162Coxa vara (HP:0002812)1.51265810
163Abnormality of cells of the erythroid lineage (HP:0012130)1.50925433
164Cellulitis (HP:0100658)1.49922646
165Difficulty climbing stairs (HP:0003551)1.48695141
166Blue sclerae (HP:0000592)1.48609839
167Mildly elevated creatine phosphokinase (HP:0008180)1.47818022
168Soft skin (HP:0000977)1.47304984
169Hypoglycemic seizures (HP:0002173)1.46909889
170Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.46734161
171Hypoplasia of the pons (HP:0012110)1.45254381
172Missing ribs (HP:0000921)1.45151768
173Spinal cord lesions (HP:0100561)1.45134255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.83666890
2SMG13.50053788
3TRIB33.45384978
4ERN13.39813100
5ICK2.76083335
6EPHA22.62167168
7EEF2K2.57984306
8PASK2.56270250
9RPS6KA42.26603654
10PKN22.19734175
11MAP3K102.05040220
12MAP3K131.90270748
13SCYL21.88837960
14MAP3K31.76079662
15STK101.71341343
16NEK21.70466010
17PDGFRA1.57699258
18CDK121.57103273
19PTK61.55258331
20NME21.53749621
21DDR21.49949113
22MAP2K21.49316572
23TAOK21.46296846
24CDC71.44849838
25LRRK21.40336872
26RPS6KB21.40171401
27FLT31.37840879
28PAK41.34471679
29TTN1.30685060
30MAP3K91.30193512
31ZAP701.30094326
32TSSK61.28612480
33PIM21.26405187
34LATS11.26273424
35BRD41.25290780
36SIK21.25107193
37BRAF1.24454091
38KSR21.23209436
39TBK11.21523439
40MAPKAPK31.19828149
41MAP3K81.18564809
42TAOK31.17526710
43MAP2K31.17198840
44TYRO31.14526839
45CHUK1.14306653
46BRSK21.12330702
47BMX1.12007831
48ARAF1.08671596
49TESK11.07266300
50TGFBR11.05833495
51CDK61.04774547
52JAK31.03930473
53ALK1.03849639
54TGFBR21.01326480
55DYRK31.01080806
56MTOR0.97097278
57PIM10.95513372
58HIPK20.92278665
59STK30.89047727
60SIK30.86664918
61MET0.86233483
62IKBKB0.85426790
63MARK20.85188669
64IRAK30.84926602
65SIK10.83019624
66PAK20.82818254
67PRKD30.81851166
68CDK40.81785255
69EPHA30.80983939
70AURKB0.79857269
71MAP4K10.78634545
72EIF2AK30.78507549
73IRAK20.78017339
74TTK0.77038587
75MST1R0.76536195
76CDK70.75982346
77FGFR40.75787345
78WEE10.75334144
79MARK30.74887077
80MAP3K20.74655827
81RIPK10.74606048
82MAPK110.73253480
83CHEK20.72453053
84PTK20.72041912
85PDGFRB0.71498168
86EIF2AK10.70422712
87ERBB30.70190308
88BUB10.70054137
89MAPK150.69416559
90MST40.68923845
91MAPKAPK20.66937246
92STK240.65664990
93DMPK0.64812121
94RPS6KL10.63815366
95RPS6KC10.63815366
96AURKA0.62914601
97MAP3K140.62020778
98MAP3K110.61222425
99FGFR30.59983715
100TAOK10.59703657
101LATS20.57818736
102MOS0.57778024
103CAMK1G0.57123410
104BRSK10.55539527
105ILK0.54072983
106CDK90.53006121
107PDPK10.52012489
108NEK10.51451513
109PDK20.50773455
110CDC42BPA0.49158397
111DYRK1B0.48851090
112CDK20.48697831
113CDK80.48518822
114RPS6KA50.47725991
115MAP3K10.47705127
116ATR0.47346742
117PLK10.46765977
118NTRK10.46416446
119RIPK40.46389966
120STK38L0.45377672
121MAP3K60.45267044
122CHEK10.44625886
123PLK30.44241761
124RPS6KA20.43818130
125ITK0.43538812
126SRPK10.43488083
127GSK3A0.43108869
128AKT20.41702157
129RPS6KA10.41209896
130RPS6KA60.40915284
131VRK10.40797271
132TYK20.40787240
133RAF10.39943836
134CDK11A0.39072804
135TRPM70.39049912
136MAPK120.38021310
137PAK10.37734956
138IRAK40.37597225
139NME10.37012637
140JAK20.36542426
141CAMK1D0.36086145
142PRKD20.35921343
143EPHB20.35399854
144DAPK30.34538263
145CDK10.34275694

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53833521
2One carbon pool by folate_Homo sapiens_hsa006702.37825173
3* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.27048616
4Biosynthesis of amino acids_Homo sapiens_hsa012302.18873021
5Maturity onset diabetes of the young_Homo sapiens_hsa049501.90853850
6RNA transport_Homo sapiens_hsa030131.90027237
7Legionellosis_Homo sapiens_hsa051341.83267170
8Chronic myeloid leukemia_Homo sapiens_hsa052201.72436065
9Bladder cancer_Homo sapiens_hsa052191.71412426
10DNA replication_Homo sapiens_hsa030301.71024449
11Spliceosome_Homo sapiens_hsa030401.63702169
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61606540
13Antigen processing and presentation_Homo sapiens_hsa046121.61103167
14Prion diseases_Homo sapiens_hsa050201.59208600
15Ribosome_Homo sapiens_hsa030101.58889214
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.58202457
17p53 signaling pathway_Homo sapiens_hsa041151.56896607
18Cell cycle_Homo sapiens_hsa041101.49553638
19Leishmaniasis_Homo sapiens_hsa051401.48009737
20Pentose phosphate pathway_Homo sapiens_hsa000301.43299453
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41188997
22Small cell lung cancer_Homo sapiens_hsa052221.37195811
23Fructose and mannose metabolism_Homo sapiens_hsa000511.35988933
24Vitamin B6 metabolism_Homo sapiens_hsa007501.34964320
25MicroRNAs in cancer_Homo sapiens_hsa052061.32284468
26Protein export_Homo sapiens_hsa030601.32181190
27* Apoptosis_Homo sapiens_hsa042101.31700862
28Selenocompound metabolism_Homo sapiens_hsa004501.30927172
29* Viral carcinogenesis_Homo sapiens_hsa052031.28122367
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27935806
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.25828335
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24021413
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23497873
34Adherens junction_Homo sapiens_hsa045201.23319231
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.22660970
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20378115
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19785994
38Osteoclast differentiation_Homo sapiens_hsa043801.19195596
39Insulin signaling pathway_Homo sapiens_hsa049101.17951691
40Mismatch repair_Homo sapiens_hsa034301.15703102
41Base excision repair_Homo sapiens_hsa034101.15338571
42ErbB signaling pathway_Homo sapiens_hsa040121.15208102
43* TNF signaling pathway_Homo sapiens_hsa046681.15050593
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14718127
45Acute myeloid leukemia_Homo sapiens_hsa052211.14462512
46Sulfur relay system_Homo sapiens_hsa041221.14282728
47N-Glycan biosynthesis_Homo sapiens_hsa005101.13573740
48mTOR signaling pathway_Homo sapiens_hsa041501.13400858
49Carbon metabolism_Homo sapiens_hsa012001.13278176
50* HTLV-I infection_Homo sapiens_hsa051661.11899053
51Herpes simplex infection_Homo sapiens_hsa051681.09386236
52Proteoglycans in cancer_Homo sapiens_hsa052051.08959158
53mRNA surveillance pathway_Homo sapiens_hsa030151.08760690
54Epstein-Barr virus infection_Homo sapiens_hsa051691.08654790
55Toxoplasmosis_Homo sapiens_hsa051451.07055233
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02470857
57TGF-beta signaling pathway_Homo sapiens_hsa043501.00865300
58Glioma_Homo sapiens_hsa052141.00844184
59* Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00363360
60Pancreatic cancer_Homo sapiens_hsa052120.99386007
61* Hepatitis B_Homo sapiens_hsa051610.96988296
62Thyroid cancer_Homo sapiens_hsa052160.96427337
63Prolactin signaling pathway_Homo sapiens_hsa049170.94699538
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94044816
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94031957
66Notch signaling pathway_Homo sapiens_hsa043300.93405147
67Measles_Homo sapiens_hsa051620.92984584
68Focal adhesion_Homo sapiens_hsa045100.92687676
69Shigellosis_Homo sapiens_hsa051310.92632552
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92270762
71ECM-receptor interaction_Homo sapiens_hsa045120.90652415
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90262565
73AMPK signaling pathway_Homo sapiens_hsa041520.89629881
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.88628297
75Influenza A_Homo sapiens_hsa051640.87066709
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87026592
77Insulin resistance_Homo sapiens_hsa049310.86428819
78Lysosome_Homo sapiens_hsa041420.85902946
79HIF-1 signaling pathway_Homo sapiens_hsa040660.84706141
80Hippo signaling pathway_Homo sapiens_hsa043900.84464410
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.83367741
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82772767
83Colorectal cancer_Homo sapiens_hsa052100.82300757
84* Prostate cancer_Homo sapiens_hsa052150.82059596
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.81683390
86Endometrial cancer_Homo sapiens_hsa052130.81347829
87Protein digestion and absorption_Homo sapiens_hsa049740.81028289
88* Neurotrophin signaling pathway_Homo sapiens_hsa047220.78718288
89Arginine biosynthesis_Homo sapiens_hsa002200.77984820
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77844723
91B cell receptor signaling pathway_Homo sapiens_hsa046620.77458513
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76680158
93Galactose metabolism_Homo sapiens_hsa000520.75835074
94Other glycan degradation_Homo sapiens_hsa005110.75473973
95Nucleotide excision repair_Homo sapiens_hsa034200.75323898
96Tuberculosis_Homo sapiens_hsa051520.74965591
97FoxO signaling pathway_Homo sapiens_hsa040680.72601272
98Amoebiasis_Homo sapiens_hsa051460.72263636
99Type I diabetes mellitus_Homo sapiens_hsa049400.72196882
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72057841
101Malaria_Homo sapiens_hsa051440.70110906
102Choline metabolism in cancer_Homo sapiens_hsa052310.67486045
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.67279807
104Lysine degradation_Homo sapiens_hsa003100.66563651
105Non-small cell lung cancer_Homo sapiens_hsa052230.66309413
106Arginine and proline metabolism_Homo sapiens_hsa003300.65491954
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65481178
108Systemic lupus erythematosus_Homo sapiens_hsa053220.65331704
109RNA degradation_Homo sapiens_hsa030180.64962442
110* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64644945
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63818966
112Melanoma_Homo sapiens_hsa052180.63259019
113Hematopoietic cell lineage_Homo sapiens_hsa046400.62806086
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61597747
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60638578
116Renal cell carcinoma_Homo sapiens_hsa052110.58512231
117Pyrimidine metabolism_Homo sapiens_hsa002400.57999839
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57841750
119Pertussis_Homo sapiens_hsa051330.57321447
120Pathways in cancer_Homo sapiens_hsa052000.57204402
121Hepatitis C_Homo sapiens_hsa051600.56896950
122VEGF signaling pathway_Homo sapiens_hsa043700.56753300
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56304700
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55994774
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.55767593
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55111451
127Salmonella infection_Homo sapiens_hsa051320.54596685
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54170407
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53652469
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49474827
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.47727299
132Vibrio cholerae infection_Homo sapiens_hsa051100.47654334
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44712894

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »