ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.34625422
2	viral transcription (GO:0019083)	7.54613724
3	translational termination (GO:0006415)	7.19201931
4	regulation of oxidative stress-induced neuron death (GO:1903203)	6.99808242
5	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	6.51709694
6	negative regulation of glycogen biosynthetic process (GO:0045719)	6.46966290
7	regulation of cellular respiration (GO:0043457)	6.21685369
8	ribosomal small subunit assembly (GO:0000028)	6.20512292
9	negative regulation of cardiac muscle hypertrophy (GO:0010614)	6.04807687
10	translational elongation (GO:0006414)	5.99478592
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.93053923
12	cotranslational protein targeting to membrane (GO:0006613)	5.84072453
13	protein targeting to ER (GO:0045047)	5.80065290
14	viral life cycle (GO:0019058)	5.78555771
15	tolerance induction (GO:0002507)	5.75690182
16	N-terminal protein amino acid acetylation (GO:0006474)	5.73501044
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.50996118
18	negative regulation of muscle hypertrophy (GO:0014741)	5.48710295
19	regulation of interleukin-12 biosynthetic process (GO:0045075)	5.46803026
20	cellular protein complex disassembly (GO:0043624)	5.44230909
21	protein localization to endoplasmic reticulum (GO:0070972)	5.39296104
22	ribonucleoprotein complex biogenesis (GO:0022613)	5.30535534
23	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	5.18397296
24	negative regulation of glycogen metabolic process (GO:0070874)	5.14000972
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.13465645
26	regulation of energy homeostasis (GO:2000505)	5.01986914
27	ribosomal large subunit biogenesis (GO:0042273)	4.85820748
28	interleukin-6-mediated signaling pathway (GO:0070102)	4.80671558
29	galactose catabolic process (GO:0019388)	4.73436931
30	membrane tubulation (GO:0097320)	4.69434162
31	protein complex disassembly (GO:0043241)	4.55308784
32	ribosome biogenesis (GO:0042254)	4.51610137
33	translational initiation (GO:0006413)	4.50302570
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.41535128
35	ATP synthesis coupled proton transport (GO:0015986)	4.41535128
36	cellular response to interleukin-6 (GO:0071354)	4.20218115
37	macromolecular complex disassembly (GO:0032984)	4.14698052
38	cellular component biogenesis (GO:0044085)	4.09018780
39	water-soluble vitamin biosynthetic process (GO:0042364)	4.03754661
40	forebrain morphogenesis (GO:0048853)	4.02232454
41	ubiquinone biosynthetic process (GO:0006744)	3.99851114
42	respiratory chain complex IV assembly (GO:0008535)	3.97767979
43	maturation of SSU-rRNA (GO:0030490)	3.95178272
44	cysteine metabolic process (GO:0006534)	3.92817952
45	protein targeting to membrane (GO:0006612)	3.92658968
46	translation (GO:0006412)	3.89010784
47	cytochrome complex assembly (GO:0017004)	3.76749804
48	adaptation of signaling pathway (GO:0023058)	3.66832702
49	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.62272387
50	negative regulation of potassium ion transport (GO:0043267)	3.59590381
51	positive regulation of T cell apoptotic process (GO:0070234)	3.53873545
52	superoxide anion generation (GO:0042554)	3.52911303
53	endoderm formation (GO:0001706)	3.51989117
54	mitochondrial calcium ion transport (GO:0006851)	3.49369005
55	response to interleukin-6 (GO:0070741)	3.46911496
56	ubiquinone metabolic process (GO:0006743)	3.46346194
57	response to pheromone (GO:0019236)	3.41506548
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.41488205
59	positive regulation of protein homooligomerization (GO:0032464)	3.36102749
60	quinone biosynthetic process (GO:1901663)	3.23711615
61	mRNA catabolic process (GO:0006402)	3.22952386
62	regulation of proton transport (GO:0010155)	3.22902744
63	ATP biosynthetic process (GO:0006754)	3.20725190
64	chaperone-mediated protein transport (GO:0072321)	3.18958963
65	sequestering of actin monomers (GO:0042989)	3.18790931
66	protein neddylation (GO:0045116)	3.12159704
67	behavioral response to nicotine (GO:0035095)	3.09436781
68	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.08040803
69	response to nitrosative stress (GO:0051409)	3.06684306
70	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.03172696
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.99497143
72	protein heterotetramerization (GO:0051290)	2.98025304
73	piRNA metabolic process (GO:0034587)	2.97928278
74	mesonephros development (GO:0001823)	2.96595718
75	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.96179642
76	L-phenylalanine catabolic process (GO:0006559)	2.96179642
77	negative regulation of T cell differentiation in thymus (GO:0033085)	2.94638057
78	valine metabolic process (GO:0006573)	2.90666740
79	RNA catabolic process (GO:0006401)	2.84032462
80	oxygen transport (GO:0015671)	2.82742801
81	maturation of 5.8S rRNA (GO:0000460)	2.81272779
82	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.79471105
83	rRNA processing (GO:0006364)	2.75487786
84	tyrosine metabolic process (GO:0006570)	2.74436858
85	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.74124424
86	megakaryocyte development (GO:0035855)	2.71637193
87	lymph node development (GO:0048535)	2.70454406
88	GTP biosynthetic process (GO:0006183)	2.67873581
89	protein localization to endosome (GO:0036010)	2.67212625
90	response to misfolded protein (GO:0051788)	2.66769461
91	rRNA metabolic process (GO:0016072)	2.65722871
92	ncRNA 3-end processing (GO:0043628)	2.65631886
93	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.64745570
94	pharyngeal system development (GO:0060037)	2.63781705
95	regulation of mesoderm development (GO:2000380)	2.62302142
96	DNA deamination (GO:0045006)	2.60358132
97	establishment of protein localization to membrane (GO:0090150)	2.60103536
98	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.59456486
99	protein targeting (GO:0006605)	2.58148879
100	regulation of hypersensitivity (GO:0002883)	2.54080213

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.59625078
2	VDR_22108803_ChIP-Seq_LS180_Human	3.65164900
3	SRY_22984422_ChIP-ChIP_TESTIS_Rat	3.46548154
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93982287
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.72939886
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.65488689
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.55122796
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.43724924
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.39436629
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.21045414
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.20924007
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20801349
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.16317181
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12766056
15	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	2.10888051
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99988192
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.95037361
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.84637707
19	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.78238698
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77902786
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71703437
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68068738
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.67817013
24	SA1_27219007_Chip-Seq_Bcells_Human	1.65705289
25	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.65686699
26	NCOR_22424771_ChIP-Seq_293T_Human	1.65104319
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.55639040
28	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.53929584
29	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.52121407
30	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.51491616
31	BCL6_27268052_Chip-Seq_Bcells_Human	1.47937572
32	NANOG_20526341_ChIP-Seq_ESCs_Human	1.47100960
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46465879
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.45230155
35	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.42731599
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.39924347
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38374453
38	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.38295536
39	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.38139492
40	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.36209927
41	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.36209927
42	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.36209927
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.35254474
44	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.34025926
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.33341289
46	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33224316
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31984042
48	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.30402705
49	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.29810102
50	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28950094
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.28340981
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27309129
53	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.26814712
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.26448712
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25894235
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.24952386
57	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.24280969
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.23114952
59	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23022360
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.22924264
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.21424136
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.20978708
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.19608518
64	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19554429
65	P300_27268052_Chip-Seq_Bcells_Human	1.18828343
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.16562817
67	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.16046424
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.15944399
69	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15294669
70	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.14500474
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.14333517
72	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14219003
73	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.13767718
74	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.12807006
75	TP53_22127205_ChIP-Seq_IMR90_Human	1.11764671
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11396559
77	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.10958081
78	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10635044
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.10209473
80	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.09915592
81	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.07735460
82	RAC3_21632823_ChIP-Seq_H3396_Human	1.07691776
83	ER_23166858_ChIP-Seq_MCF-7_Human	1.05934830
84	CTCF_20526341_ChIP-Seq_ESCs_Human	1.04001255
85	VDR_21846776_ChIP-Seq_THP-1_Human	1.01776230
86	P68_20966046_ChIP-Seq_HELA_Human	1.01371354
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01275059
88	BCOR_27268052_Chip-Seq_Bcells_Human	0.99833837
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97925077
90	ERA_21632823_ChIP-Seq_H3396_Human	0.95937212
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94798777
92	E2F1_20622854_ChIP-Seq_HELA_Human	0.93800621
93	DROSHA_22980978_ChIP-Seq_HELA_Human	0.92334496
94	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.91919795
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91855259
96	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.91225491
97	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90290309
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89640031
99	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.89149459
100	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.88533021

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	7.64674837
2	MP0002653_abnormal_ependyma_morphology	4.98092059
3	MP0002837_dystrophic_cardiac_calcinosis	4.73348797
4	MP0005623_abnormal_meninges_morphology	3.51400675
5	MP0009379_abnormal_foot_pigmentation	3.49203352
6	MP0004145_abnormal_muscle_electrophysio	3.27219543
7	MP0004084_abnormal_cardiac_muscle	3.11852942
8	MP0003279_aneurysm	2.75542011
9	MP0005360_urolithiasis	2.67529899
10	MP0002163_abnormal_gland_morphology	2.67497473
11	MP0003195_calcinosis	2.44449884
12	MP0006292_abnormal_olfactory_placode	2.41972099
13	MP0003646_muscle_fatigue	2.29718859
14	MP0004885_abnormal_endolymph	2.07145307
15	MP0001986_abnormal_taste_sensitivity	2.06742754
16	MP0005377_hearing/vestibular/ear_phenot	2.02727689
17	MP0003878_abnormal_ear_physiology	2.02727689
18	MP0003186_abnormal_redox_activity	1.99681488
19	MP0001764_abnormal_homeostasis	1.85271924
20	MP0001915_intracranial_hemorrhage	1.71471697
21	MP0002160_abnormal_reproductive_system	1.67601071
22	MP0004036_abnormal_muscle_relaxation	1.64488577
23	MP0004130_abnormal_muscle_cell	1.59406986
24	MP0005379_endocrine/exocrine_gland_phen	1.52017088
25	MP0004742_abnormal_vestibular_system	1.48713401
26	MP0009333_abnormal_splenocyte_physiolog	1.46119372
27	MP0000678_abnormal_parathyroid_gland	1.44232764
28	MP0001968_abnormal_touch/_nociception	1.41369813
29	MP0004381_abnormal_hair_follicle	1.37191998
30	MP0008872_abnormal_physiological_respon	1.37012370
31	MP0005389_reproductive_system_phenotype	1.32840903
32	MP0004215_abnormal_myocardial_fiber	1.26014298
33	MP0005220_abnormal_exocrine_pancreas	1.23512391
34	MP0009785_altered_susceptibility_to	1.22878292
35	MP0002693_abnormal_pancreas_physiology	1.21064257
36	MP0003011_delayed_dark_adaptation	1.15925598
37	MP0005646_abnormal_pituitary_gland	1.15341242
38	MP0001348_abnormal_lacrimal_gland	1.14425184
39	MP0005671_abnormal_response_to	1.13107669
40	MP0002277_abnormal_respiratory_mucosa	1.10234582
41	MP0001800_abnormal_humoral_immune	1.07095204
42	MP0005332_abnormal_amino_acid	1.06591701
43	MP0008875_abnormal_xenobiotic_pharmacok	1.04993870
44	MP0001919_abnormal_reproductive_system	1.02265683
45	MP0000685_abnormal_immune_system	1.01431159
46	MP0009250_abnormal_appendicular_skeleto	1.00696726
47	MP0009765_abnormal_xenobiotic_induced	1.00291329
48	MP0003693_abnormal_embryo_hatching	0.99844501
49	MP0000049_abnormal_middle_ear	0.99329078
50	MP0008775_abnormal_heart_ventricle	0.98340983
51	MP0001944_abnormal_pancreas_morphology	0.98136959
52	MP0004147_increased_porphyrin_level	0.96829087
53	MP0005645_abnormal_hypothalamus_physiol	0.92115967
54	MP0008877_abnormal_DNA_methylation	0.87762966
55	MP0002095_abnormal_skin_pigmentation	0.87311172
56	MP0001501_abnormal_sleep_pattern	0.86057455
57	MP0005084_abnormal_gallbladder_morpholo	0.85689142
58	MP0002272_abnormal_nervous_system	0.85394823
59	MP0002736_abnormal_nociception_after	0.84693128
60	MP0002876_abnormal_thyroid_physiology	0.83417339
61	MP0009745_abnormal_behavioral_response	0.81439070
62	MP0002102_abnormal_ear_morphology	0.81251057
63	MP0003136_yellow_coat_color	0.80916838
64	MP0002751_abnormal_autonomic_nervous	0.78746594
65	MP0002723_abnormal_immune_serum	0.78401102
66	MP0002733_abnormal_thermal_nociception	0.78282332
67	MP0004484_altered_response_of	0.75367829
68	MP0004019_abnormal_vitamin_homeostasis	0.72166399
69	MP0003633_abnormal_nervous_system	0.70663537
70	MP0005636_abnormal_mineral_homeostasis	0.68929363
71	MP0001905_abnormal_dopamine_level	0.68540463
72	MP0003786_premature_aging	0.67860499
73	MP0010155_abnormal_intestine_physiology	0.66065942
74	MP0003119_abnormal_digestive_system	0.65561314
75	MP0003879_abnormal_hair_cell	0.64649912
76	MP0002822_catalepsy	0.64100771
77	MP0003303_peritoneal_inflammation	0.62214215
78	MP0005410_abnormal_fertilization	0.62013274
79	MP0000767_abnormal_smooth_muscle	0.61753062
80	MP0005551_abnormal_eye_electrophysiolog	0.61434645
81	MP0003866_abnormal_defecation	0.59764961
82	MP0003567_abnormal_fetal_cardiomyocyte	0.57634746
83	MP0005334_abnormal_fat_pad	0.56939343
84	MP0003936_abnormal_reproductive_system	0.56661927
85	MP0002184_abnormal_innervation	0.56484503
86	MP0005448_abnormal_energy_balance	0.56383769
87	MP0002127_abnormal_cardiovascular_syste	0.55810698
88	MP0001970_abnormal_pain_threshold	0.54677219
89	MP0006072_abnormal_retinal_apoptosis	0.53941135
90	MP0001756_abnormal_urination	0.53830286
91	MP0009764_decreased_sensitivity_to	0.52765181
92	MP0000538_abnormal_urinary_bladder	0.52449501
93	MP0001286_abnormal_eye_development	0.52312183
94	MP0001881_abnormal_mammary_gland	0.51368142
95	MP0005376_homeostasis/metabolism_phenot	0.48550526
96	MP0000026_abnormal_inner_ear	0.47290298
97	MP0001663_abnormal_digestive_system	0.46867214
98	MP0005083_abnormal_biliary_tract	0.46550007
99	MP0006036_abnormal_mitochondrial_physio	0.45458623
100	MP0009046_muscle_twitch	0.44436811

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	7.19031909
2	Acute necrotizing encephalopathy (HP:0006965)	5.33050197
3	Abnormal number of erythroid precursors (HP:0012131)	4.99849314
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.82335955
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.72024461
6	Absent/shortened dynein arms (HP:0200106)	4.47204876
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.47204876
8	Progressive macrocephaly (HP:0004481)	4.37135564
9	Acute encephalopathy (HP:0006846)	4.35958798
10	Progressive inability to walk (HP:0002505)	4.05495416
11	Mitochondrial inheritance (HP:0001427)	3.85931006
12	Hepatocellular necrosis (HP:0001404)	3.83337952
13	Congenital stationary night blindness (HP:0007642)	3.58237169
14	Increased CSF lactate (HP:0002490)	3.52539328
15	Hypomagnesemia (HP:0002917)	3.49979531
16	Abnormal hemoglobin (HP:0011902)	3.47709293
17	Abnormality of magnesium homeostasis (HP:0004921)	3.42303760
18	Hepatic necrosis (HP:0002605)	3.39282192
19	Mutism (HP:0002300)	3.36055930
20	Cerebral edema (HP:0002181)	3.24003618
21	Tetany (HP:0001281)	3.23526605
22	Hypergonadotropic hypogonadism (HP:0000815)	3.16382297
23	Premature ovarian failure (HP:0008209)	3.11602644
24	Optic disc pallor (HP:0000543)	3.05707431
25	Pallor (HP:0000980)	2.98712402
26	Macrocytic anemia (HP:0001972)	2.85436454
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84297042
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84297042
29	Abnormality of alanine metabolism (HP:0010916)	2.82031526
30	Hyperalaninemia (HP:0003348)	2.82031526
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.82031526
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.74350799
33	Increased serum lactate (HP:0002151)	2.70729016
34	Polydipsia (HP:0001959)	2.68956860
35	Abnormal drinking behavior (HP:0030082)	2.68956860
36	Elfin facies (HP:0004428)	2.67625090
37	Abnormal respiratory epithelium morphology (HP:0012253)	2.67423727
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.67423727
39	Constricted visual fields (HP:0001133)	2.66845950
40	Overriding aorta (HP:0002623)	2.66819524
41	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.60157377
42	Chronic otitis media (HP:0000389)	2.59701551
43	Renal Fanconi syndrome (HP:0001994)	2.56317889
44	Abnormal ciliary motility (HP:0012262)	2.52530609
45	Hypoplasia of the uterus (HP:0000013)	2.50513875
46	Leukodystrophy (HP:0002415)	2.50355819
47	Polyuria (HP:0000103)	2.48267636
48	Gastrointestinal infarctions (HP:0005244)	2.45505643
49	Aplasia/hypoplasia of the uterus (HP:0008684)	2.41343222
50	Rhinitis (HP:0012384)	2.39068004
51	3-Methylglutaconic aciduria (HP:0003535)	2.38339819
52	Pancreatic fibrosis (HP:0100732)	2.36421031
53	Abnormal respiratory motile cilium physiology (HP:0012261)	2.36004712
54	Stomatitis (HP:0010280)	2.32545975
55	Renovascular hypertension (HP:0100817)	2.31806856
56	True hermaphroditism (HP:0010459)	2.31506498
57	Increased intramyocellular lipid droplets (HP:0012240)	2.28847123
58	Pancreatic cysts (HP:0001737)	2.25785217
59	Exertional dyspnea (HP:0002875)	2.20671395
60	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.18111564
61	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.18111564
62	Dyskinesia (HP:0100660)	2.17514251
63	Generalized aminoaciduria (HP:0002909)	2.14443312
64	Inability to walk (HP:0002540)	2.14271464
65	Flat cornea (HP:0007720)	2.12801614
66	Abnormal urine output (HP:0012590)	2.06979854
67	Exercise intolerance (HP:0003546)	2.06708581
68	Pendular nystagmus (HP:0012043)	2.06271125
69	Increased hepatocellular lipid droplets (HP:0006565)	2.02534807
70	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.01689833
71	Lactic acidosis (HP:0003128)	1.99113411
72	Respiratory failure (HP:0002878)	1.97638400
73	Reticulocytopenia (HP:0001896)	1.97129536
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95341906
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93878726
76	Renal duplication (HP:0000075)	1.91792368
77	Abnormality of urine glucose concentration (HP:0011016)	1.89524527
78	Glycosuria (HP:0003076)	1.89524527
79	Hypercalciuria (HP:0002150)	1.88822971
80	Abnormality of renal excretion (HP:0011036)	1.87696952
81	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87247426
82	Increased muscle lipid content (HP:0009058)	1.85816392
83	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.79582239
84	Metabolic alkalosis (HP:0200114)	1.79498398
85	Lipid accumulation in hepatocytes (HP:0006561)	1.77152441
86	Insomnia (HP:0100785)	1.75809451
87	Lethargy (HP:0001254)	1.75712391
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.74757456
89	Anencephaly (HP:0002323)	1.74621760
90	Hypokalemic alkalosis (HP:0001949)	1.70382639
91	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.70198762
92	Cystic liver disease (HP:0006706)	1.70156617
93	Aortic regurgitation (HP:0001659)	1.68293990
94	Loss of speech (HP:0002371)	1.65679193
95	Renal tubular dysfunction (HP:0000124)	1.63517545
96	Abnormality of the corticospinal tract (HP:0002492)	1.62569035
97	Chronic sinusitis (HP:0011109)	1.59998885
98	Abnormal number of incisors (HP:0011064)	1.59400134
99	Renal tubular acidosis (HP:0001947)	1.59371798
100	Adducted thumb (HP:0001181)	1.59204980

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMKK1	5.03730641
2	MAP3K13	4.66080357
3	TXK	3.78918270
4	MAP4K1	3.22865503
5	RIPK4	2.60501484
6	CAMKK2	2.03906054
7	PASK	10.2183817
8	MAP3K14	1.93781340
9	SIK2	1.85815853
10	LRRK2	1.84396874
11	BMPR1B	1.64951403
12	NME2	1.44902914
13	ADRBK2	1.42976228
14	BTK	1.25311156
15	IKBKB	1.22775204
16	GRK1	1.11560470
17	PRKCQ	1.11109551
18	TGFBR1	1.11068589
19	WNK4	1.09455341
20	FRK	1.05165286
21	MAP4K2	1.01868109
22	BRSK2	1.01517393
23	TIE1	0.98348602
24	SYK	0.97653456
25	MUSK	0.94071342
26	TEC	0.93691593
27	TAOK3	0.92822068
28	JAK3	0.90742297
29	DYRK2	0.90198038
30	ZAK	0.88989781
31	MARK3	0.86301240
32	PTK6	0.83340296
33	PAK6	0.77958336
34	TLK1	0.77185057
35	PKN2	0.74854451
36	ADRBK1	0.72840473
37	ITK	0.72774517
38	FLT3	0.65618272
39	MAPKAPK3	0.64843920
40	CHUK	0.64383871
41	PIK3CA	0.63153077
42	PRKCG	0.61434009
43	PINK1	0.61003522
44	MKNK2	0.60814247
45	BCKDK	0.58792328
46	KDR	0.58680625
47	INSRR	0.58204922
48	ACVR1B	0.57175872
49	LCK	0.56625289
50	PDK1	0.54411985
51	MAPK15	0.52271224
52	PRKCD	0.51612427
53	BRSK1	0.51010754
54	PRKCZ	0.50580061
55	STK11	0.49929884
56	NEK1	0.49657914
57	STK4	0.49160290
58	CSNK1G3	0.47940561
59	NEK2	0.43550699
60	RPS6KA5	0.42403135
61	STK16	0.42132636
62	PAK2	0.41521258
63	DMPK	0.41147454
64	OBSCN	0.40159124
65	EPHA2	0.39720301
66	PAK1	0.38413880
67	MAP3K7	0.36823086
68	OXSR1	0.36726470
69	CSNK1G1	0.36004412
70	WNK3	0.35412745
71	NLK	0.34865105
72	MAPK13	0.34266741
73	PRKCA	0.34167854
74	TNIK	0.34146707
75	PDK2	0.33165602
76	CLK1	0.32458555
77	ZAP70	0.31982982
78	LYN	0.31481793
79	MAP3K9	0.30800958
80	EIF2AK1	0.30712838
81	ABL2	0.30304780
82	CDC7	0.30109965
83	TYRO3	0.28769976
84	CSNK2A2	0.28676259
85	PRKAA2	0.28291016
86	PLK1	0.27314470
87	MKNK1	0.26742084
88	CSNK1G2	0.26473826
89	PRKACA	0.26395951
90	RPS6KB2	0.24911911
91	AURKA	0.24841366
92	CSNK1A1L	0.21605011
93	MAP3K11	0.21602061
94	PLK4	0.20406554
95	PRKG2	0.20285828
96	ILK	0.20056398
97	CSNK2A1	0.19994392
98	GSK3A	0.18688510
99	CSNK1A1	0.18633541
100	PIK3CG	0.18203130

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.26783844
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	4.06595949
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.49975618
4	Parkinsons disease_Homo sapiens_hsa05012	2.46845472
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.34538605
6	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.10972923
7	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.09705788
8	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.06499634
9	RNA polymerase_Homo sapiens_hsa03020	2.05266325
10	Proteasome_Homo sapiens_hsa03050	2.00954978
11	Phototransduction_Homo sapiens_hsa04744	1.85435458
12	Huntingtons disease_Homo sapiens_hsa05016	1.79452645
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.74032615
14	Asthma_Homo sapiens_hsa05310	1.68707680
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60708840
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.52497117
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50012937
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48477975
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.46686646
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46166028
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45775165
22	Alzheimers disease_Homo sapiens_hsa05010	1.39757761
23	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32018002
24	Homologous recombination_Homo sapiens_hsa03440	1.31279485
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28903312
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.28157985
27	Galactose metabolism_Homo sapiens_hsa00052	1.23475395
28	Sulfur metabolism_Homo sapiens_hsa00920	1.21423325
29	Allograft rejection_Homo sapiens_hsa05330	1.20083746
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19665359
31	Cocaine addiction_Homo sapiens_hsa05030	1.16919011
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.08471301
33	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.04852408
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03753378
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03312308
36	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.99641322
37	Primary immunodeficiency_Homo sapiens_hsa05340	0.98510217
38	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98141410
39	One carbon pool by folate_Homo sapiens_hsa00670	0.98061223
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97825783
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.97575385
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92970327
43	Graft-versus-host disease_Homo sapiens_hsa05332	0.92179785
44	Insulin secretion_Homo sapiens_hsa04911	0.91390069
45	Caffeine metabolism_Homo sapiens_hsa00232	0.90710184
46	Tyrosine metabolism_Homo sapiens_hsa00350	0.88380680
47	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.86823578
48	Nicotine addiction_Homo sapiens_hsa05033	0.85898182
49	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.85667660
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84324885
51	Base excision repair_Homo sapiens_hsa03410	0.84001733
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83052883
53	Purine metabolism_Homo sapiens_hsa00230	0.82779796
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.81107216
55	RNA degradation_Homo sapiens_hsa03018	0.79905388
56	Sulfur relay system_Homo sapiens_hsa04122	0.79764920
57	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.77833789
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77489195
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.76679481
60	Olfactory transduction_Homo sapiens_hsa04740	0.75392894
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70422385
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.67986816
63	Metabolic pathways_Homo sapiens_hsa01100	0.64422517
64	DNA replication_Homo sapiens_hsa03030	0.63932208
65	Morphine addiction_Homo sapiens_hsa05032	0.62946261
66	Basal transcription factors_Homo sapiens_hsa03022	0.62832877
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62665409
68	Amphetamine addiction_Homo sapiens_hsa05031	0.61077626
69	African trypanosomiasis_Homo sapiens_hsa05143	0.60406667
70	Salivary secretion_Homo sapiens_hsa04970	0.59977583
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.56760759
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.56576633
73	ABC transporters_Homo sapiens_hsa02010	0.54280787
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.54002272
75	Antigen processing and presentation_Homo sapiens_hsa04612	0.52887135
76	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.52744703
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47442993
78	p53 signaling pathway_Homo sapiens_hsa04115	0.42309431
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40476040
80	Taste transduction_Homo sapiens_hsa04742	0.39697152
81	Mismatch repair_Homo sapiens_hsa03430	0.38089254
82	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.37150872
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.35080587
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.33134170
85	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33049654
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33048617
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32340762
88	Retinol metabolism_Homo sapiens_hsa00830	0.30921787
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28227964
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.27155687
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.26723159
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.24776968
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24235914
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21771487
95	Chemokine signaling pathway_Homo sapiens_hsa04062	0.21540999
96	Apoptosis_Homo sapiens_hsa04210	0.19952241
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.18344030
98	Malaria_Homo sapiens_hsa05144	0.17243431
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17079636
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.16907505

ATF4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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