ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.45363704
2	translational termination (GO:0006415)	7.02474054
3	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.86284149
4	ribosomal small subunit biogenesis (GO:0042274)	5.80558663
5	cotranslational protein targeting to membrane (GO:0006613)	5.79103204
6	protein targeting to ER (GO:0045047)	5.70064423
7	translational elongation (GO:0006414)	5.67220163
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.43878385
9	ribosomal small subunit assembly (GO:0000028)	5.38808398
10	protein localization to endoplasmic reticulum (GO:0070972)	5.31973699
11	cellular protein complex disassembly (GO:0043624)	5.29315099
12	viral life cycle (GO:0019058)	5.07827291
13	maturation of SSU-rRNA (GO:0030490)	5.01993241
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.83248326
15	protein complex disassembly (GO:0043241)	4.50536647
16	behavioral response to nicotine (GO:0035095)	4.26796595
17	macromolecular complex disassembly (GO:0032984)	4.24052310
18	translational initiation (GO:0006413)	4.23586601
19	central nervous system myelination (GO:0022010)	3.97930091
20	axon ensheathment in central nervous system (GO:0032291)	3.97930091
21	nephron tubule morphogenesis (GO:0072078)	3.96092455
22	nephron epithelium morphogenesis (GO:0072088)	3.96092455
23	ribosomal large subunit biogenesis (GO:0042273)	3.91593863
24	protein targeting to membrane (GO:0006612)	3.79013684
25	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.76247176
26	substrate-independent telencephalic tangential migration (GO:0021826)	3.76247176
27	ATP synthesis coupled proton transport (GO:0015986)	3.71592835
28	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.71592835
29	peristalsis (GO:0030432)	3.69998907
30	adaptation of signaling pathway (GO:0023058)	3.68453628
31	endothelial cell chemotaxis (GO:0035767)	3.58302197
32	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.56310009
33	cellular response to nicotine (GO:0071316)	3.49923298
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.44684593
35	neuron fate determination (GO:0048664)	3.41370358
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33682343
37	NADH dehydrogenase complex assembly (GO:0010257)	3.33682343
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33682343
39	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.30347249
40	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.28868267
41	cardiovascular system development (GO:0072358)	3.19066766
42	galactose catabolic process (GO:0019388)	3.15365463
43	alanine transport (GO:0032328)	3.13686693
44	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.08525956
45	pyrimidine nucleobase catabolic process (GO:0006208)	3.03067489
46	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.02394968
47	nonmotile primary cilium assembly (GO:0035058)	3.02159934
48	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.02026473
49	respiratory electron transport chain (GO:0022904)	3.00692597
50	electron transport chain (GO:0022900)	3.00029087
51	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.99321714
52	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.98061618
53	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.98061618
54	dopamine biosynthetic process (GO:0042416)	2.97952078
55	behavioral response to cocaine (GO:0048148)	2.96168365
56	ribonucleoprotein complex biogenesis (GO:0022613)	2.93966459
57	translation (GO:0006412)	2.92599329
58	mRNA catabolic process (GO:0006402)	2.91550391
59	axonal fasciculation (GO:0007413)	2.91488522
60	renal tubule morphogenesis (GO:0061333)	2.88506518
61	dendritic spine morphogenesis (GO:0060997)	2.86643524
62	protein neddylation (GO:0045116)	2.83535460
63	rRNA catabolic process (GO:0016075)	2.83363247
64	homocysteine metabolic process (GO:0050667)	2.82934958
65	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.81100478
66	Sertoli cell development (GO:0060009)	2.81059926
67	protein complex biogenesis (GO:0070271)	2.78423936
68	N-glycan processing (GO:0006491)	2.78360377
69	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.77570879
70	negative regulation of astrocyte differentiation (GO:0048712)	2.77559524
71	male meiosis (GO:0007140)	2.76800203
72	proline transport (GO:0015824)	2.74340083
73	cellular component biogenesis (GO:0044085)	2.73651317
74	regulation of cellular respiration (GO:0043457)	2.72132415
75	regulation of catecholamine metabolic process (GO:0042069)	2.71668482
76	regulation of dopamine metabolic process (GO:0042053)	2.71668482
77	arachidonic acid secretion (GO:0050482)	2.70912310
78	icosanoid secretion (GO:0032309)	2.70912310
79	establishment of protein localization to membrane (GO:0090150)	2.65355233
80	negative regulation of glycogen biosynthetic process (GO:0045719)	2.61935114
81	exocrine pancreas development (GO:0031017)	2.61542443
82	otic vesicle formation (GO:0030916)	2.61258842
83	cochlea development (GO:0090102)	2.59854247
84	cysteine metabolic process (GO:0006534)	2.59726283
85	RNA catabolic process (GO:0006401)	2.59091598
86	hydrogen ion transmembrane transport (GO:1902600)	2.57797474
87	response to amphetamine (GO:0001975)	2.57777787
88	L-serine metabolic process (GO:0006563)	2.57526365
89	dopamine metabolic process (GO:0042417)	2.57124681
90	dopamine transport (GO:0015872)	2.57026305
91	alkaloid metabolic process (GO:0009820)	2.56858244
92	water-soluble vitamin biosynthetic process (GO:0042364)	2.56510972
93	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.53751007
94	proton transport (GO:0015992)	2.53544686
95	epithelial cilium movement (GO:0003351)	2.52417245
96	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.52253123
97	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.50795519
98	centriole replication (GO:0007099)	2.50676488
99	lens fiber cell development (GO:0070307)	2.50619954
100	regulation of glycogen (starch) synthase activity (GO:2000465)	2.50375291

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.09155398
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.59578509
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.93174829
4	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.56298607
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.54619229
6	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.54431577
7	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.50768495
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33871453
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.32604062
10	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.24483947
11	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.24483947
12	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.23826440
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22782565
14	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.21183768
15	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.10169673
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.05967965
17	VDR_22108803_ChIP-Seq_LS180_Human	2.03066196
18	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.01521061
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.00190915
20	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.95884258
21	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.94490274
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.87855755
23	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.87283435
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86712066
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.85525414
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.85443585
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78361889
28	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.77729065
29	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.75925849
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72900309
31	EWS_26573619_Chip-Seq_HEK293_Human	1.70470928
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.68834900
33	FUS_26573619_Chip-Seq_HEK293_Human	1.62861892
34	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.61602878
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.59998970
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.58103706
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.56281511
38	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.47283358
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.45175733
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43638099
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42870135
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.41044972
43	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.40752402
44	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40075576
45	P300_19829295_ChIP-Seq_ESCs_Human	1.38621935
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32297331
47	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.26716406
48	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.23038138
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.20892362
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20057043
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17985907
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16621763
53	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.16485485
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.16200081
55	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.14945486
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13959419
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10932667
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10644553
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.09772386
60	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.08386523
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08241637
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.07914066
63	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.07055574
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06027233
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05323039
66	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.04494403
67	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.04313416
68	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03910144
69	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03910144
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02419337
71	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02170880
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01708034
73	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00680787
74	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.99274444
75	MYC_18940864_ChIP-ChIP_HL60_Human	0.98236631
76	DROSHA_22980978_ChIP-Seq_HELA_Human	0.98229056
77	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.97621402
78	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.95489373
79	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94655933
80	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92797309
81	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92283059
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92248995
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.92074883
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91518320
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.91193986
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90932512
87	JUN_21703547_ChIP-Seq_K562_Human	0.90782979
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89486255
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89159815
90	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.89000046
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88232006
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.87831003
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.87831003
94	AR_25329375_ChIP-Seq_VCAP_Human	0.87729653
95	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.87094290
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.86650159
97	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.86481842
98	TAF15_26573619_Chip-Seq_HEK293_Human	0.85938087
99	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.85810757
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.85571523

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.24495398
2	MP0000566_synostosis	4.20475767
3	MP0003122_maternal_imprinting	3.26132849
4	MP0005423_abnormal_somatic_nervous	3.14410085
5	MP0006292_abnormal_olfactory_placode	2.75424845
6	MP0006276_abnormal_autonomic_nervous	2.46105278
7	MP0004142_abnormal_muscle_tone	2.44684588
8	MP0003787_abnormal_imprinting	2.33306613
9	MP0003011_delayed_dark_adaptation	2.19646837
10	MP0008877_abnormal_DNA_methylation	2.18634808
11	MP0004885_abnormal_endolymph	2.12170606
12	MP0003121_genomic_imprinting	1.99714844
13	MP0002653_abnormal_ependyma_morphology	1.98428265
14	MP0000372_irregular_coat_pigmentation	1.94183836
15	MP0002272_abnormal_nervous_system	1.93380172
16	MP0002837_dystrophic_cardiac_calcinosis	1.92419111
17	MP0002938_white_spotting	1.90252536
18	MP0000569_abnormal_digit_pigmentation	1.88822381
19	MP0003186_abnormal_redox_activity	1.87872597
20	MP0005646_abnormal_pituitary_gland	1.85454661
21	MP0003315_abnormal_perineum_morphology	1.85235841
22	MP0004133_heterotaxia	1.81821455
23	MP0003136_yellow_coat_color	1.77896777
24	MP0003283_abnormal_digestive_organ	1.73629472
25	MP0000778_abnormal_nervous_system	1.73191670
26	MP0000049_abnormal_middle_ear	1.68181025
27	MP0001905_abnormal_dopamine_level	1.64333286
28	MP0009745_abnormal_behavioral_response	1.62960331
29	MP0005551_abnormal_eye_electrophysiolog	1.59461322
30	MP0004145_abnormal_muscle_electrophysio	1.59404124
31	MP0002095_abnormal_skin_pigmentation	1.56290341
32	MP0002733_abnormal_thermal_nociception	1.50773418
33	MP0009046_muscle_twitch	1.50276328
34	MP0002876_abnormal_thyroid_physiology	1.50004133
35	MP0010030_abnormal_orbit_morphology	1.46953370
36	MP0002572_abnormal_emotion/affect_behav	1.44189118
37	MP0004742_abnormal_vestibular_system	1.42895904
38	MP0006072_abnormal_retinal_apoptosis	1.41957070
39	MP0001984_abnormal_olfaction	1.40806118
40	MP0002638_abnormal_pupillary_reflex	1.39896466
41	MP0002735_abnormal_chemical_nociception	1.36952974
42	MP0003880_abnormal_central_pattern	1.36598759
43	MP0001293_anophthalmia	1.34525642
44	MP0000631_abnormal_neuroendocrine_gland	1.34201438
45	MP0008872_abnormal_physiological_respon	1.33893605
46	MP0002160_abnormal_reproductive_system	1.33569602
47	MP0000026_abnormal_inner_ear	1.30378396
48	MP0002234_abnormal_pharynx_morphology	1.28900103
49	MP0002102_abnormal_ear_morphology	1.28255444
50	MP0002063_abnormal_learning/memory/cond	1.28151884
51	MP0002734_abnormal_mechanical_nocicepti	1.25538077
52	MP0001502_abnormal_circadian_rhythm	1.25014172
53	MP0002557_abnormal_social/conspecific_i	1.25003034
54	MP0001529_abnormal_vocalization	1.24163546
55	MP0004147_increased_porphyrin_level	1.23958571
56	MP0002064_seizures	1.23458806
57	MP0001970_abnormal_pain_threshold	1.21788237
58	MP0008875_abnormal_xenobiotic_pharmacok	1.21507113
59	MP0009250_abnormal_appendicular_skeleto	1.21505931
60	MP0001440_abnormal_grooming_behavior	1.17578465
61	MP0001968_abnormal_touch/_nociception	1.17322515
62	MP0003635_abnormal_synaptic_transmissio	1.14373338
63	MP0002184_abnormal_innervation	1.14118875
64	MP0001986_abnormal_taste_sensitivity	1.13134553
65	MP0005195_abnormal_posterior_eye	1.12732966
66	MP0005645_abnormal_hypothalamus_physiol	1.11608040
67	MP0005377_hearing/vestibular/ear_phenot	1.11235629
68	MP0003878_abnormal_ear_physiology	1.11235629
69	MP0003123_paternal_imprinting	1.07695832
70	MP0005389_reproductive_system_phenotype	1.06417391
71	MP0002752_abnormal_somatic_nervous	1.05984528
72	MP0000955_abnormal_spinal_cord	1.05576204
73	MP0005174_abnormal_tail_pigmentation	1.03319845
74	MP0001346_abnormal_lacrimal_gland	1.01440217
75	MP0003942_abnormal_urinary_system	0.99430981
76	MP0008789_abnormal_olfactory_epithelium	0.99243728
77	MP0001919_abnormal_reproductive_system	0.98630966
78	MP0001486_abnormal_startle_reflex	0.97085259
79	MP0005187_abnormal_penis_morphology	0.96603040
80	MP0002736_abnormal_nociception_after	0.95731488
81	MP0001286_abnormal_eye_development	0.95153193
82	MP0002067_abnormal_sensory_capabilities	0.94736462
83	MP0003937_abnormal_limbs/digits/tail_de	0.92722853
84	MP0003195_calcinosis	0.92607219
85	MP0002229_neurodegeneration	0.92546585
86	MP0001963_abnormal_hearing_physiology	0.92375149
87	MP0002882_abnormal_neuron_morphology	0.88280910
88	MP0002277_abnormal_respiratory_mucosa	0.85620343
89	MP0001188_hyperpigmentation	0.80362666
90	MP0005171_absent_coat_pigmentation	0.80178844
91	MP0002909_abnormal_adrenal_gland	0.78473131
92	MP0003938_abnormal_ear_development	0.78169050
93	MP0005084_abnormal_gallbladder_morpholo	0.74971362
94	MP0001324_abnormal_eye_pigmentation	0.72764277
95	MP0000534_abnormal_ureter_morphology	0.72238210
96	MP0005253_abnormal_eye_physiology	0.71967027
97	MP0004019_abnormal_vitamin_homeostasis	0.71502920
98	MP0005386_behavior/neurological_phenoty	0.70467394
99	MP0004924_abnormal_behavior	0.70467394
100	MP0003631_nervous_system_phenotype	0.70396389

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.49332284
2	Reticulocytopenia (HP:0001896)	5.09264111
3	Abnormality of the labia minora (HP:0012880)	4.50107817
4	Stenosis of the external auditory canal (HP:0000402)	4.16444769
5	Abnormality of midbrain morphology (HP:0002418)	3.94627810
6	Molar tooth sign on MRI (HP:0002419)	3.94627810
7	Abnormal number of erythroid precursors (HP:0012131)	3.89246790
8	Macrocytic anemia (HP:0001972)	3.88413962
9	Increased corneal curvature (HP:0100692)	3.69685238
10	Keratoconus (HP:0000563)	3.69685238
11	Abnormal hemoglobin (HP:0011902)	3.67130974
12	Concave nail (HP:0001598)	3.54134242
13	Limb dystonia (HP:0002451)	3.43551543
14	Pallor (HP:0000980)	3.39916987
15	Pancreatic fibrosis (HP:0100732)	3.37457783
16	Acute necrotizing encephalopathy (HP:0006965)	3.29046668
17	Chronic hepatic failure (HP:0100626)	3.14593598
18	True hermaphroditism (HP:0010459)	3.08185950
19	Oligomenorrhea (HP:0000876)	2.96534295
20	Pancreatic cysts (HP:0001737)	2.89633885
21	Pendular nystagmus (HP:0012043)	2.88309970
22	Progressive cerebellar ataxia (HP:0002073)	2.84562901
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.78424066
24	Acute encephalopathy (HP:0006846)	2.68854003
25	Myokymia (HP:0002411)	2.66004059
26	Mitochondrial inheritance (HP:0001427)	2.60595178
27	Chorioretinal atrophy (HP:0000533)	2.56976865
28	Agitation (HP:0000713)	2.55097610
29	Progressive macrocephaly (HP:0004481)	2.54463635
30	Cystic liver disease (HP:0006706)	2.48211195
31	Decreased central vision (HP:0007663)	2.44101019
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.40481824
33	Absent/shortened dynein arms (HP:0200106)	2.40481824
34	Anencephaly (HP:0002323)	2.39993976
35	Labial hypoplasia (HP:0000066)	2.31570494
36	Hypogonadotrophic hypogonadism (HP:0000044)	2.31013765
37	Septo-optic dysplasia (HP:0100842)	2.30526892
38	Ulnar claw (HP:0001178)	2.29482864
39	Medial flaring of the eyebrow (HP:0010747)	2.28232168
40	Increased CSF lactate (HP:0002490)	2.27872054
41	Maternal diabetes (HP:0009800)	2.26925033
42	Optic disc pallor (HP:0000543)	2.24596635
43	Absent thumb (HP:0009777)	2.21719973
44	Synostosis involving the elbow (HP:0003938)	2.20858068
45	Humeroradial synostosis (HP:0003041)	2.20858068
46	Congenital stationary night blindness (HP:0007642)	2.16135022
47	Partial duplication of thumb phalanx (HP:0009944)	2.15739961
48	Hepatocellular necrosis (HP:0001404)	2.12012170
49	Hypoplastic female external genitalia (HP:0012815)	2.11607623
50	Abnormal rod and cone electroretinograms (HP:0008323)	2.11423845
51	Nephronophthisis (HP:0000090)	2.11303284
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.10222461
53	Sclerocornea (HP:0000647)	2.08335189
54	Thyroid-stimulating hormone excess (HP:0002925)	2.07242293
55	Male pseudohermaphroditism (HP:0000037)	2.07224631
56	Shawl scrotum (HP:0000049)	2.04535988
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04254819
58	Abnormality of alanine metabolism (HP:0010916)	2.04254819
59	Hyperalaninemia (HP:0003348)	2.04254819
60	Depressed nasal ridge (HP:0000457)	2.03810241
61	3-Methylglutaconic aciduria (HP:0003535)	1.99003454
62	Abnormal respiratory epithelium morphology (HP:0012253)	1.97510382
63	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97510382
64	Hypoplasia of the radius (HP:0002984)	1.97320244
65	Triphalangeal thumb (HP:0001199)	1.96661013
66	Birth length less than 3rd percentile (HP:0003561)	1.95061044
67	Type II lissencephaly (HP:0007260)	1.92026721
68	Sleep apnea (HP:0010535)	1.91513988
69	Hypoplasia of the ulna (HP:0003022)	1.89521286
70	Cerebral edema (HP:0002181)	1.89223779
71	Abnormality of the renal medulla (HP:0100957)	1.88993219
72	Narrow forehead (HP:0000341)	1.88238316
73	11 pairs of ribs (HP:0000878)	1.84754100
74	Congenital, generalized hypertrichosis (HP:0004540)	1.84726445
75	Gait imbalance (HP:0002141)	1.84640062
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80403816
77	Polyphagia (HP:0002591)	1.79997181
78	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.77948424
79	Tachypnea (HP:0002789)	1.75497689
80	Hypothermia (HP:0002045)	1.74435158
81	Hepatic necrosis (HP:0002605)	1.74292903
82	Anophthalmia (HP:0000528)	1.73969002
83	Retinal dysplasia (HP:0007973)	1.72823854
84	Partial duplication of the phalanx of hand (HP:0009999)	1.71130896
85	Morphological abnormality of the pyramidal tract (HP:0002062)	1.70823240
86	Abnormality of the middle phalanges of the toes (HP:0010183)	1.70602509
87	Congenital sensorineural hearing impairment (HP:0008527)	1.69961652
88	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69194542
89	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.67926022
90	Abnormal ciliary motility (HP:0012262)	1.67568645
91	Genetic anticipation (HP:0003743)	1.67168718
92	Hyperthyroidism (HP:0000836)	1.66785641
93	Congenital primary aphakia (HP:0007707)	1.66424312
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.61733160
95	Thickened helices (HP:0000391)	1.61271702
96	Action tremor (HP:0002345)	1.60086147
97	Hyperphosphatemia (HP:0002905)	1.59718363
98	Hypoplasia of the uterus (HP:0000013)	1.59421005
99	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.58967671
100	Absent septum pellucidum (HP:0001331)	1.58520148

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	3.60064580
2	PASK	3.47763899
3	DYRK2	3.38495633
4	MAP3K12	3.36988790
5	MAP4K2	3.27587002
6	PNCK	3.17267900
7	CASK	2.59981261
8	NTRK2	2.57073767
9	WNK3	2.56845145
10	EPHB2	2.15429059
11	GRK1	2.15247481
12	MARK1	2.10531098
13	LRRK2	2.06971536
14	WNK4	1.87063576
15	TNIK	1.81691036
16	MAP3K11	1.76007970
17	MAPK15	1.65360751
18	TXK	1.62699578
19	SGK223	1.59104534
20	SGK494	1.59104534
21	NTRK3	1.58469022
22	PHKG2	1.58021884
23	PHKG1	1.58021884
24	PRKCG	1.47642655
25	CDK19	1.33053772
26	MAPKAPK5	1.31428819
27	BCKDK	1.29317614
28	MAPK13	1.27974611
29	PRKCH	1.24951964
30	MKNK2	1.17332869
31	PINK1	1.17209042
32	PAK3	1.15550191
33	PIK3CA	1.11386284
34	MAP2K4	1.11350749
35	ZAK	1.10254204
36	STK16	1.01926541
37	PRKCQ	1.00589998
38	TAOK3	0.99711166
39	STK11	0.96869090
40	MARK3	0.90792542
41	TLK1	0.90300442
42	RPS6KA6	0.89330910
43	BMPR1B	0.86265368
44	SGK1	0.83311755
45	MUSK	0.83212182
46	OXSR1	0.81885131
47	PRKACA	0.81723452
48	TGFBR1	0.81068902
49	ADRBK1	0.80959666
50	CAMKK1	0.79314258
51	DAPK3	0.78965717
52	INSRR	0.75362233
53	FRK	0.74170770
54	PKN1	0.72511963
55	TIE1	0.71255265
56	AURKB	0.70366853
57	CAMK1	0.66763408
58	CSNK1G2	0.66593793
59	MAPK11	0.66060241
60	PRKCI	0.65468873
61	PRKCE	0.65400129
62	MAP3K4	0.65280369
63	RPS6KA5	0.64795633
64	ABL2	0.64700264
65	AURKA	0.64124248
66	RPS6KC1	0.62109606
67	RPS6KL1	0.62109606
68	FGFR2	0.61458085
69	CHEK2	0.59389709
70	OBSCN	0.58381137
71	MINK1	0.54716434
72	PRKCZ	0.53277520
73	CAMK2A	0.53201693
74	CAMK2D	0.51831997
75	RPS6KA1	0.49262365
76	TYRO3	0.47837951
77	CSNK1E	0.47641394
78	EPHA4	0.47062591
79	MAP2K7	0.46942026
80	SIK2	0.45599309
81	MAP3K2	0.45130644
82	CSNK2A2	0.43180312
83	PIM1	0.42592991
84	KSR1	0.41854368
85	CAMK2B	0.40894805
86	MAP2K2	0.40202995
87	SGK2	0.39716669
88	MAPK12	0.39455464
89	ERBB2	0.39224640
90	RPS6KB2	0.39152495
91	CDK5	0.39097571
92	NTRK1	0.38940279
93	PRKCD	0.38153918
94	STK39	0.36908152
95	UHMK1	0.35212089
96	PRKG1	0.33701385
97	PRKCA	0.33194450
98	DYRK1A	0.33048738
99	NUAK1	0.29465325
100	TSSK6	0.29139309

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.50861682
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.15303863
3	Parkinsons disease_Homo sapiens_hsa05012	3.48959973
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.87661831
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.54602533
6	Nicotine addiction_Homo sapiens_hsa05033	2.47745281
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.36243517
8	Alzheimers disease_Homo sapiens_hsa05010	2.29347589
9	Basal transcription factors_Homo sapiens_hsa03022	2.28321550
10	Huntingtons disease_Homo sapiens_hsa05016	2.24341854
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.21936257
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.17774633
13	Morphine addiction_Homo sapiens_hsa05032	1.83138189
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.68761056
15	Cocaine addiction_Homo sapiens_hsa05030	1.64270871
16	Phototransduction_Homo sapiens_hsa04744	1.62935863
17	Butanoate metabolism_Homo sapiens_hsa00650	1.60449262
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.55625242
19	Protein export_Homo sapiens_hsa03060	1.45341850
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37578295
21	Olfactory transduction_Homo sapiens_hsa04740	1.36350134
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.33919992
23	Insulin secretion_Homo sapiens_hsa04911	1.32005339
24	GABAergic synapse_Homo sapiens_hsa04727	1.25470079
25	Sulfur metabolism_Homo sapiens_hsa00920	1.20536518
26	Amphetamine addiction_Homo sapiens_hsa05031	1.18560107
27	Basal cell carcinoma_Homo sapiens_hsa05217	1.17961732
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.17769562
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.08666702
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.07727854
31	Tyrosine metabolism_Homo sapiens_hsa00350	1.06160763
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.05527480
33	One carbon pool by folate_Homo sapiens_hsa00670	1.04890539
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02463133
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01378534
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00838045
37	Serotonergic synapse_Homo sapiens_hsa04726	1.00171654
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.99623224
39	Sulfur relay system_Homo sapiens_hsa04122	0.99401599
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95603771
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94769169
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93729819
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91476644
44	Retinol metabolism_Homo sapiens_hsa00830	0.90216623
45	Caffeine metabolism_Homo sapiens_hsa00232	0.85474835
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85064880
47	RNA polymerase_Homo sapiens_hsa03020	0.83898342
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83580902
49	Taste transduction_Homo sapiens_hsa04742	0.82611230
50	Axon guidance_Homo sapiens_hsa04360	0.82115321
51	Circadian entrainment_Homo sapiens_hsa04713	0.80588114
52	Histidine metabolism_Homo sapiens_hsa00340	0.79496268
53	Nucleotide excision repair_Homo sapiens_hsa03420	0.76553361
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75685240
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74676344
56	Bile secretion_Homo sapiens_hsa04976	0.73216949
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70252941
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67019536
59	RNA degradation_Homo sapiens_hsa03018	0.62689594
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62045589
61	Gastric acid secretion_Homo sapiens_hsa04971	0.61827278
62	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.60094470
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59572088
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.59089602
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.58075672
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55580657
67	Peroxisome_Homo sapiens_hsa04146	0.54607148
68	Cholinergic synapse_Homo sapiens_hsa04725	0.53901747
69	Salivary secretion_Homo sapiens_hsa04970	0.53759790
70	Metabolic pathways_Homo sapiens_hsa01100	0.51333431
71	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50749072
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48578431
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.46101757
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45976816
75	Regulation of autophagy_Homo sapiens_hsa04140	0.44837448
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44714707
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.42746427
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42475799
79	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.42380264
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42059130
81	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41445002
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40990762
83	Phenylalanine metabolism_Homo sapiens_hsa00360	0.40974542
84	Asthma_Homo sapiens_hsa05310	0.40183770
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.40033588
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36468611
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34047672
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.34036389
89	Mineral absorption_Homo sapiens_hsa04978	0.33152043
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.32505549
91	Alcoholism_Homo sapiens_hsa05034	0.32336126
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31514043
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30730630
94	Circadian rhythm_Homo sapiens_hsa04710	0.30608182
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29661187
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29404524
97	Galactose metabolism_Homo sapiens_hsa00052	0.29366088
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.29033223
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28743420
100	Melanogenesis_Homo sapiens_hsa04916	0.28638075

ATF4P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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