ATF4P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.04651424
2translational termination (GO:0006415)6.65097359
3ribosomal small subunit biogenesis (GO:0042274)6.10387628
4behavioral response to nicotine (GO:0035095)5.58071826
5cotranslational protein targeting to membrane (GO:0006613)5.43652371
6translational elongation (GO:0006414)5.42604579
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.39992714
8protein targeting to ER (GO:0045047)5.32385994
9positive regulation of gastrulation (GO:2000543)5.27954712
10cellular protein complex disassembly (GO:0043624)5.14919897
11cell proliferation in forebrain (GO:0021846)5.13106193
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.12313570
13viral life cycle (GO:0019058)5.08821314
14negative regulation of glycogen biosynthetic process (GO:0045719)5.02734271
15negative regulation of cardiac muscle hypertrophy (GO:0010614)4.99093575
16ATP synthesis coupled proton transport (GO:0015986)4.98325757
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.98325757
18protein localization to endoplasmic reticulum (GO:0070972)4.95706946
19ribosomal small subunit assembly (GO:0000028)4.89600424
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.73094377
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67387503
22negative regulation of muscle hypertrophy (GO:0014741)4.49936075
23protein complex disassembly (GO:0043241)4.38560978
24macromolecular complex disassembly (GO:0032984)4.16633235
25translational initiation (GO:0006413)3.99824742
26retinal ganglion cell axon guidance (GO:0031290)3.94716818
27negative regulation of glycogen metabolic process (GO:0070874)3.92667219
28somite development (GO:0061053)3.92147420
29primitive streak formation (GO:0090009)3.90474722
30maturation of SSU-rRNA (GO:0030490)3.87877827
31pyrimidine nucleobase catabolic process (GO:0006208)3.86340047
32endoderm formation (GO:0001706)3.71633203
33genetic imprinting (GO:0071514)3.56734983
34protein targeting to membrane (GO:0006612)3.53857910
35somite rostral/caudal axis specification (GO:0032525)3.53062992
36protein neddylation (GO:0045116)3.50679854
37head development (GO:0060322)3.45974439
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.41386563
39forebrain morphogenesis (GO:0048853)3.38359670
40telencephalon development (GO:0021537)3.36418727
41dopaminergic neuron differentiation (GO:0071542)3.33451672
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32701356
43positive regulation of T cell apoptotic process (GO:0070234)3.31672095
44ribosomal large subunit biogenesis (GO:0042273)3.31135368
45neurofilament cytoskeleton organization (GO:0060052)3.30678813
46negative regulation of mast cell activation (GO:0033004)3.29576482
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28989453
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.28989453
49NADH dehydrogenase complex assembly (GO:0010257)3.28989453
50protein complex biogenesis (GO:0070271)3.26734450
51vitamin A metabolic process (GO:0006776)3.24977413
52response to dietary excess (GO:0002021)3.20887636
53regulation of glycogen (starch) synthase activity (GO:2000465)3.15989093
54respiratory electron transport chain (GO:0022904)3.15569181
55electron transport chain (GO:0022900)3.13072537
56nucleobase catabolic process (GO:0046113)3.12851317
57sequestering of actin monomers (GO:0042989)3.08903836
58spinal cord association neuron differentiation (GO:0021527)3.08577269
59otic vesicle formation (GO:0030916)3.05512249
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.04849587
61negative regulation of amino acid transport (GO:0051956)3.03660069
62arginine catabolic process (GO:0006527)3.00932526
63establishment of mitochondrion localization (GO:0051654)2.96313036
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95136787
65synaptic transmission, cholinergic (GO:0007271)2.95029623
66ubiquinone biosynthetic process (GO:0006744)2.93316275
67ATP biosynthetic process (GO:0006754)2.92079469
68midbrain development (GO:0030901)2.91925330
69urogenital system development (GO:0001655)2.91635081
70mRNA catabolic process (GO:0006402)2.90530550
71regulation of gene expression by genetic imprinting (GO:0006349)2.89141563
72mitochondrial respiratory chain complex assembly (GO:0033108)2.86147679
73ubiquinone metabolic process (GO:0006743)2.84581645
74cardiac left ventricle morphogenesis (GO:0003214)2.82200516
75L-fucose metabolic process (GO:0042354)2.79776225
76L-fucose catabolic process (GO:0042355)2.79776225
77fucose catabolic process (GO:0019317)2.79776225
78translation (GO:0006412)2.74839277
79regulation of energy homeostasis (GO:2000505)2.74590139
80hydrogen ion transmembrane transport (GO:1902600)2.71914182
81response to redox state (GO:0051775)2.69725063
82regulation of mesoderm development (GO:2000380)2.65811257
83negative regulation of T cell differentiation in thymus (GO:0033085)2.64346996
84regulation of cilium movement (GO:0003352)2.60552538
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.59960567
86cellular component biogenesis (GO:0044085)2.57623956
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57015245
88isoprenoid biosynthetic process (GO:0008299)2.57002750
89cysteine metabolic process (GO:0006534)2.56957396
90proton transport (GO:0015992)2.56123799
91arginine metabolic process (GO:0006525)2.54874711
92RNA catabolic process (GO:0006401)2.54442682
93ribonucleoprotein complex biogenesis (GO:0022613)2.53059313
94central nervous system myelination (GO:0022010)2.52143002
95axon ensheathment in central nervous system (GO:0032291)2.52143002
96negative regulation of cardiac muscle tissue development (GO:0055026)2.52133324
97hydrogen transport (GO:0006818)2.51098841
98purine nucleoside triphosphate biosynthetic process (GO:0009145)2.48987670
99axonemal dynein complex assembly (GO:0070286)2.48136667
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45731233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72560435
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.14982099
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.71748013
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61386040
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.61104043
6VDR_22108803_ChIP-Seq_LS180_Human2.50173551
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.47246609
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42965840
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.38832673
10ZNF274_21170338_ChIP-Seq_K562_Hela2.28540418
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.27349505
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20275250
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19336806
14REST_21632747_ChIP-Seq_MESCs_Mouse2.11510852
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09131558
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03973561
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98317470
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97355278
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88365988
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88365988
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88122072
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.81459692
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77660201
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77638733
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.72822831
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69005606
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66487754
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63426734
29IRF1_19129219_ChIP-ChIP_H3396_Human1.57310468
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.57068624
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56925257
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56411619
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.52616722
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50820062
35FUS_26573619_Chip-Seq_HEK293_Human1.50764881
36RNF2_27304074_Chip-Seq_NSC_Mouse1.48007242
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.47963606
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45855441
39EWS_26573619_Chip-Seq_HEK293_Human1.45141417
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41844727
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40013035
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39670614
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37286046
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36944650
45TP53_22573176_ChIP-Seq_HFKS_Human1.32504625
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.32332287
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.30328166
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.29980068
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.29843139
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28943738
51DROSHA_22980978_ChIP-Seq_HELA_Human1.28110507
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26329115
53GBX2_23144817_ChIP-Seq_PC3_Human1.23221690
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22476731
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.21614789
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19461935
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.16900707
58CTCF_27219007_Chip-Seq_Bcells_Human1.15697486
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15167403
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14639018
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14639018
62MYC_18940864_ChIP-ChIP_HL60_Human1.12874004
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12458646
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10854274
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.10081677
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09209150
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08926678
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08459892
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08326200
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06795034
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06577538
72NCOR_22424771_ChIP-Seq_293T_Human1.06139808
73P300_19829295_ChIP-Seq_ESCs_Human1.04518729
74NANOG_20526341_ChIP-Seq_ESCs_Human1.02463007
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02243035
76CBP_20019798_ChIP-Seq_JUKART_Human0.99962674
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99962674
78P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97879166
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97702492
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97066217
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.95801011
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94249388
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93507738
84ETS1_20019798_ChIP-Seq_JURKAT_Human0.93059921
85TAF2_19829295_ChIP-Seq_ESCs_Human0.92056568
86IGF1R_20145208_ChIP-Seq_DFB_Human0.90181354
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88595680
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87764685
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87048317
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86896070
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86864043
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85991552
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85638976
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85344742
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84754589
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84233995
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.83799853
98ER_23166858_ChIP-Seq_MCF-7_Human0.83561589
99ERA_21632823_ChIP-Seq_H3396_Human0.83158148
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83103590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.33390830
2MP0009379_abnormal_foot_pigmentation4.14830927
3MP0000566_synostosis3.65543308
4MP0006292_abnormal_olfactory_placode3.53396909
5MP0003787_abnormal_imprinting2.71185024
6MP0003011_delayed_dark_adaptation2.65606184
7MP0003122_maternal_imprinting2.54294976
8MP0003136_yellow_coat_color2.47477645
9MP0002837_dystrophic_cardiac_calcinosis2.34296537
10MP0003890_abnormal_embryonic-extraembry2.27938213
11MP0005423_abnormal_somatic_nervous2.12673407
12MP0002163_abnormal_gland_morphology2.10729278
13MP0004145_abnormal_muscle_electrophysio2.03202555
14MP0004142_abnormal_muscle_tone2.03151053
15MP0004885_abnormal_endolymph1.97085209
16MP0008877_abnormal_DNA_methylation1.91468332
17MP0001485_abnormal_pinna_reflex1.86105133
18MP0000049_abnormal_middle_ear1.85571254
19MP0003121_genomic_imprinting1.78947902
20MP0001986_abnormal_taste_sensitivity1.77685155
21MP0003646_muscle_fatigue1.70087103
22MP0000778_abnormal_nervous_system1.62632829
23MP0004742_abnormal_vestibular_system1.62518584
24MP0001968_abnormal_touch/_nociception1.60664097
25MP0006276_abnormal_autonomic_nervous1.60024043
26MP0001293_anophthalmia1.58170375
27MP0002938_white_spotting1.49607757
28MP0005360_urolithiasis1.48041974
29MP0004133_heterotaxia1.47141104
30MP0002272_abnormal_nervous_system1.44459893
31MP0001440_abnormal_grooming_behavior1.44407673
32MP0000569_abnormal_digit_pigmentation1.43022259
33MP0003123_paternal_imprinting1.40090887
34MP0005379_endocrine/exocrine_gland_phen1.39668821
35MP0002733_abnormal_thermal_nociception1.35366244
36MP0004130_abnormal_muscle_cell1.35041325
37MP0008875_abnormal_xenobiotic_pharmacok1.33050296
38MP0003879_abnormal_hair_cell1.30592319
39MP0005551_abnormal_eye_electrophysiolog1.30523126
40MP0000026_abnormal_inner_ear1.28807999
41MP0009745_abnormal_behavioral_response1.27056313
42MP0002184_abnormal_innervation1.26139512
43MP0000631_abnormal_neuroendocrine_gland1.25171460
44MP0003119_abnormal_digestive_system1.25166018
45MP0009046_muscle_twitch1.25111535
46MP0003880_abnormal_central_pattern1.22583742
47MP0008789_abnormal_olfactory_epithelium1.22563197
48MP0003942_abnormal_urinary_system1.22395825
49MP0006072_abnormal_retinal_apoptosis1.22168625
50MP0003938_abnormal_ear_development1.19714903
51MP0000955_abnormal_spinal_cord1.19299882
52MP0001970_abnormal_pain_threshold1.18930661
53MP0005084_abnormal_gallbladder_morpholo1.18107995
54MP0003315_abnormal_perineum_morphology1.16578564
55MP0003186_abnormal_redox_activity1.14034761
56MP0005645_abnormal_hypothalamus_physiol1.13299736
57MP0003937_abnormal_limbs/digits/tail_de1.12676560
58MP0001286_abnormal_eye_development1.08529662
59MP0002557_abnormal_social/conspecific_i1.08434427
60MP0005394_taste/olfaction_phenotype1.08292706
61MP0005499_abnormal_olfactory_system1.08292706
62MP0001188_hyperpigmentation1.07604081
63MP0002572_abnormal_emotion/affect_behav1.06963735
64MP0002638_abnormal_pupillary_reflex1.06839486
65MP0001905_abnormal_dopamine_level1.06833307
66MP0002277_abnormal_respiratory_mucosa1.06705242
67MP0002063_abnormal_learning/memory/cond1.06190602
68MP0002160_abnormal_reproductive_system1.02453528
69MP0002064_seizures1.02433663
70MP0001963_abnormal_hearing_physiology1.02098171
71MP0003635_abnormal_synaptic_transmissio1.01573350
72MP0002752_abnormal_somatic_nervous1.00908165
73MP0009250_abnormal_appendicular_skeleto1.00852600
74MP0005253_abnormal_eye_physiology0.98423405
75MP0008872_abnormal_physiological_respon0.97465387
76MP0002736_abnormal_nociception_after0.96114664
77MP0003567_abnormal_fetal_cardiomyocyte0.95887475
78MP0004019_abnormal_vitamin_homeostasis0.95332000
79MP0005389_reproductive_system_phenotype0.92633889
80MP0002067_abnormal_sensory_capabilities0.89523471
81MP0002234_abnormal_pharynx_morphology0.89483043
82MP0002282_abnormal_trachea_morphology0.86150427
83MP0001486_abnormal_startle_reflex0.84703333
84MP0002697_abnormal_eye_size0.83536492
85MP0003878_abnormal_ear_physiology0.83117983
86MP0005377_hearing/vestibular/ear_phenot0.83117983
87MP0002734_abnormal_mechanical_nocicepti0.82774520
88MP0005391_vision/eye_phenotype0.82671638
89MP0005195_abnormal_posterior_eye0.82356758
90MP0002102_abnormal_ear_morphology0.81763339
91MP0002249_abnormal_larynx_morphology0.81551569
92MP0002928_abnormal_bile_duct0.80703176
93MP0002882_abnormal_neuron_morphology0.79970433
94MP0002909_abnormal_adrenal_gland0.78209514
95MP0001919_abnormal_reproductive_system0.77573408
96MP0004811_abnormal_neuron_physiology0.76355302
97MP0006054_spinal_hemorrhage0.74541235
98MP0005187_abnormal_penis_morphology0.74073052
99MP0003755_abnormal_palate_morphology0.73476149
100MP0000647_abnormal_sebaceous_gland0.72676881

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)5.04087491
2Reticulocytopenia (HP:0001896)3.76641606
3Abnormality of cells of the erythroid lineage (HP:0012130)3.44478873
4Type 2 muscle fiber atrophy (HP:0003554)3.23416761
5Anophthalmia (HP:0000528)3.22599834
6Acute necrotizing encephalopathy (HP:0006965)3.20752032
7Nephronophthisis (HP:0000090)3.11084934
8Abnormal respiratory epithelium morphology (HP:0012253)3.09938094
9Abnormal respiratory motile cilium morphology (HP:0005938)3.09938094
10Rib fusion (HP:0000902)3.08116597
11Absent/shortened dynein arms (HP:0200106)3.05679422
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.05679422
13Mitochondrial inheritance (HP:0001427)2.97402321
14Abnormal ciliary motility (HP:0012262)2.96501527
15Septo-optic dysplasia (HP:0100842)2.91545725
16Abnormal number of erythroid precursors (HP:0012131)2.89318779
17Abnormal mitochondria in muscle tissue (HP:0008316)2.87028002
18Concave nail (HP:0001598)2.83034279
19Muscle fiber atrophy (HP:0100295)2.74509993
20Macrocytic anemia (HP:0001972)2.73570722
21Polyphagia (HP:0002591)2.72151550
22Acute encephalopathy (HP:0006846)2.68590710
23Bilateral microphthalmos (HP:0007633)2.67232734
24True hermaphroditism (HP:0010459)2.51139560
25Abnormality of the labia minora (HP:0012880)2.49790153
26Increased CSF lactate (HP:0002490)2.47204013
27Progressive macrocephaly (HP:0004481)2.46106253
28Type II lissencephaly (HP:0007260)2.44384834
29Abnormal respiratory motile cilium physiology (HP:0012261)2.43202080
30Lipid accumulation in hepatocytes (HP:0006561)2.37847068
31Molar tooth sign on MRI (HP:0002419)2.37297053
32Abnormality of midbrain morphology (HP:0002418)2.37297053
33Polyuria (HP:0000103)2.37251797
34Increased hepatocellular lipid droplets (HP:0006565)2.36903316
35Morphological abnormality of the middle ear (HP:0008609)2.36854974
36Pancreatic fibrosis (HP:0100732)2.36537877
37Abnormality of the renal medulla (HP:0100957)2.35942661
38Severe visual impairment (HP:0001141)2.35762873
39Pancreatic cysts (HP:0001737)2.33199018
40Pallor (HP:0000980)2.33129980
41Limb dystonia (HP:0002451)2.32208166
42Tubular atrophy (HP:0000092)2.32054546
43Medial flaring of the eyebrow (HP:0010747)2.31101047
44Agitation (HP:0000713)2.27675977
45Hepatocellular necrosis (HP:0001404)2.25717073
46Abnormal rod and cone electroretinograms (HP:0008323)2.24434799
47Hypomagnesemia (HP:0002917)2.21458201
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20932454
49Abnormality of the diencephalon (HP:0010662)2.19696315
50Progressive cerebellar ataxia (HP:0002073)2.19613640
51Abnormal hemoglobin (HP:0011902)2.18749207
52Myokymia (HP:0002411)2.17418256
53Sclerocornea (HP:0000647)2.17228982
54Impulsivity (HP:0100710)2.16951205
55Progressive inability to walk (HP:0002505)2.16871361
563-Methylglutaconic aciduria (HP:0003535)2.16674734
57Inability to walk (HP:0002540)2.16179839
58Optic disc pallor (HP:0000543)2.15457498
59Pachygyria (HP:0001302)2.15049865
60Congenital stationary night blindness (HP:0007642)2.13506159
61Gait imbalance (HP:0002141)2.11025821
62Renal Fanconi syndrome (HP:0001994)2.09320000
63Renovascular hypertension (HP:0100817)2.08986965
64Abnormal pancreas size (HP:0012094)2.02572886
65Polydipsia (HP:0001959)2.02436665
66Abnormal drinking behavior (HP:0030082)2.02436665
67Occipital encephalocele (HP:0002085)2.02310190
68Lissencephaly (HP:0001339)2.01698386
69Absent septum pellucidum (HP:0001331)1.99960720
70Abnormality of magnesium homeostasis (HP:0004921)1.99876935
71Abnormal number of incisors (HP:0011064)1.98712076
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95705800
73Elfin facies (HP:0004428)1.95206446
74Shawl scrotum (HP:0000049)1.94790741
75Vaginal atresia (HP:0000148)1.94373303
76Abnormal urine output (HP:0012590)1.94252254
77Abnormality of renal resorption (HP:0011038)1.94242311
78Abnormality of renal excretion (HP:0011036)1.92374296
79Maternal diabetes (HP:0009800)1.90745191
80Renal duplication (HP:0000075)1.90617780
81Specific learning disability (HP:0001328)1.89699017
82Stenosis of the external auditory canal (HP:0000402)1.89652140
83Genital tract atresia (HP:0001827)1.88267329
84Male pseudohermaphroditism (HP:0000037)1.88083806
85Hepatic necrosis (HP:0002605)1.87366735
86Hyperthyroidism (HP:0000836)1.83768412
87Abnormality of the middle phalanges of the toes (HP:0010183)1.83237907
88Spastic tetraplegia (HP:0002510)1.82089327
89Bony spicule pigmentary retinopathy (HP:0007737)1.81354740
90Coronal craniosynostosis (HP:0004440)1.81221152
91Congenital primary aphakia (HP:0007707)1.80151053
92Humeroradial synostosis (HP:0003041)1.79132892
93Synostosis involving the elbow (HP:0003938)1.79132892
94Optic nerve hypoplasia (HP:0000609)1.78170020
95Abnormality of the aortic arch (HP:0012303)1.77871935
96Intellectual disability, moderate (HP:0002342)1.77009522
97Hyperphosphatemia (HP:0002905)1.76972934
98Failure to thrive in infancy (HP:0001531)1.76654136
99Drooling (HP:0002307)1.74959350
100Anencephaly (HP:0002323)1.74041918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.63597481
2PNCK3.16001825
3DYRK22.97627276
4CAMKK12.73223896
5TNIK2.51243021
6WNK42.41701383
7ADRBK22.39093024
8CAMKK22.38284971
9MAP3K42.29811202
10EPHB22.28793005
11CASK1.95093066
12INSRR1.93840088
13MARK11.89952564
14IRAK21.86642309
15MAPK151.83533103
16TXK1.77767149
17BMPR1B1.74636086
18MAP2K71.66396910
19SGK2231.66003115
20SGK4941.66003115
21GRK11.59727635
22PRKCG1.53067650
23MAPK131.50379246
24PINK11.47117012
25NTRK21.40065862
26PRKD31.38430376
27MAP4K21.37372446
28WEE11.35220928
29TAF11.33147151
30WNK31.27405592
31BRSK21.26977427
32MUSK1.26088032
33LIMK11.25922309
34STK391.16849865
35PRKCH1.12476033
36CDK191.12012552
37BRSK11.07185386
38NEK21.02668790
39NUAK11.02113858
40TIE11.01237907
41SGK11.01060922
42LRRK21.00356392
43TGFBR10.96909093
44DYRK30.94855133
45MINK10.90799037
46PHKG10.90178210
47PHKG20.90178210
48PRKCQ0.89814850
49ADRBK10.89732231
50STK110.86431075
51STK160.85390885
52CDK80.78815959
53SGK30.78123304
54CAMK10.74862303
55UHMK10.74011810
56AURKA0.70119079
57MAP2K40.67752222
58MAP4K10.67646587
59PRKACA0.66335337
60DYRK1B0.65878583
61STK30.61954087
62VRK10.58629055
63CLK10.57201511
64CAMK1G0.56633867
65ZAK0.56312264
66OXSR10.54899404
67MAPK120.54297419
68SIK20.54098008
69CSNK1A10.52217505
70RPS6KA60.48857643
71CDC70.48563775
72PRKCZ0.48118142
73CSNK1E0.47963621
74CSNK2A20.47644379
75PAK30.47468276
76PIK3CA0.45641413
77DYRK1A0.45342787
78PKN10.44664982
79PRKCD0.43958505
80CAMK1D0.43626262
81OBSCN0.42973420
82CSNK1G20.42173689
83TYRO30.42012558
84PRKCA0.41005781
85RPS6KA50.39864105
86PDK20.37422654
87TEC0.37124319
88CDC42BPA0.36067657
89RPS6KA30.35938223
90PLK30.35753042
91PRKACG0.35635003
92CDK30.35031662
93CSNK1G10.35018047
94SGK20.34695647
95PRKG10.34656470
96RPS6KC10.34645407
97RPS6KL10.34645407
98VRK20.33757936
99CHUK0.33609455
100GSK3A0.33404335

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.61859818
2Oxidative phosphorylation_Homo sapiens_hsa001903.87498160
3Parkinsons disease_Homo sapiens_hsa050123.16799951
4Cardiac muscle contraction_Homo sapiens_hsa042602.92638533
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68970476
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.62281523
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.55333926
8Huntingtons disease_Homo sapiens_hsa050162.20652256
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.15302480
10Steroid biosynthesis_Homo sapiens_hsa001002.14228146
11Alzheimers disease_Homo sapiens_hsa050102.07353110
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03245248
13Phototransduction_Homo sapiens_hsa047442.02719629
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02514881
15Nicotine addiction_Homo sapiens_hsa050331.98625836
16Linoleic acid metabolism_Homo sapiens_hsa005911.97844143
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.73702690
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.72610741
19Morphine addiction_Homo sapiens_hsa050321.61665707
20GABAergic synapse_Homo sapiens_hsa047271.52788312
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52220740
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46289318
23Butanoate metabolism_Homo sapiens_hsa006501.37401840
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34636733
25Basal cell carcinoma_Homo sapiens_hsa052171.31919916
26Fat digestion and absorption_Homo sapiens_hsa049751.18518253
27Dopaminergic synapse_Homo sapiens_hsa047281.16079555
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.15520213
29Hedgehog signaling pathway_Homo sapiens_hsa043401.15333598
30Serotonergic synapse_Homo sapiens_hsa047261.13471346
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11400423
32Insulin secretion_Homo sapiens_hsa049111.10598854
33Protein export_Homo sapiens_hsa030601.07087695
34Nitrogen metabolism_Homo sapiens_hsa009101.06385053
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05857729
36Taste transduction_Homo sapiens_hsa047421.04018548
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01511983
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99231997
39Cocaine addiction_Homo sapiens_hsa050300.98783737
40Retinol metabolism_Homo sapiens_hsa008300.98483486
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96317457
42Olfactory transduction_Homo sapiens_hsa047400.93709686
43Basal transcription factors_Homo sapiens_hsa030220.91200905
44Glutamatergic synapse_Homo sapiens_hsa047240.90945543
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.84440128
46Circadian entrainment_Homo sapiens_hsa047130.81340162
47Sulfur metabolism_Homo sapiens_hsa009200.80389269
48Arachidonic acid metabolism_Homo sapiens_hsa005900.79786839
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79197396
50Cholinergic synapse_Homo sapiens_hsa047250.77796204
51Chemical carcinogenesis_Homo sapiens_hsa052040.77480810
52Propanoate metabolism_Homo sapiens_hsa006400.76738487
53Ether lipid metabolism_Homo sapiens_hsa005650.76244390
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75913513
55Tryptophan metabolism_Homo sapiens_hsa003800.75091090
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74696755
57Regulation of autophagy_Homo sapiens_hsa041400.71929668
58RNA degradation_Homo sapiens_hsa030180.70627039
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70005051
60Axon guidance_Homo sapiens_hsa043600.69335644
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69327695
62Hippo signaling pathway_Homo sapiens_hsa043900.65853400
63Sulfur relay system_Homo sapiens_hsa041220.64714300
64Peroxisome_Homo sapiens_hsa041460.62293720
65Metabolic pathways_Homo sapiens_hsa011000.57312224
66Amphetamine addiction_Homo sapiens_hsa050310.56512983
67Collecting duct acid secretion_Homo sapiens_hsa049660.56510915
68Notch signaling pathway_Homo sapiens_hsa043300.54455026
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.52078892
70Selenocompound metabolism_Homo sapiens_hsa004500.50405940
71Caffeine metabolism_Homo sapiens_hsa002320.49806402
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49567342
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49376583
74Tyrosine metabolism_Homo sapiens_hsa003500.44753587
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.44469888
76Fatty acid elongation_Homo sapiens_hsa000620.43599974
77RNA polymerase_Homo sapiens_hsa030200.42109943
78Asthma_Homo sapiens_hsa053100.41430713
79Ovarian steroidogenesis_Homo sapiens_hsa049130.41175120
80Fatty acid degradation_Homo sapiens_hsa000710.38619394
81Vitamin digestion and absorption_Homo sapiens_hsa049770.37836288
82Glycerolipid metabolism_Homo sapiens_hsa005610.37501234
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37388110
84Nucleotide excision repair_Homo sapiens_hsa034200.37146804
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36503788
86Ras signaling pathway_Homo sapiens_hsa040140.36350472
87Alcoholism_Homo sapiens_hsa050340.36004773
88Fatty acid metabolism_Homo sapiens_hsa012120.34881490
89Purine metabolism_Homo sapiens_hsa002300.34075194
90Pyrimidine metabolism_Homo sapiens_hsa002400.33573175
91Proteasome_Homo sapiens_hsa030500.32697969
92Synaptic vesicle cycle_Homo sapiens_hsa047210.32610931
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32279840
94Glutathione metabolism_Homo sapiens_hsa004800.30585711
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30438942
96Starch and sucrose metabolism_Homo sapiens_hsa005000.30047064
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29780831
98Wnt signaling pathway_Homo sapiens_hsa043100.29064402
99Bile secretion_Homo sapiens_hsa049760.27727620
100Salivary secretion_Homo sapiens_hsa049700.25063862

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