ATF6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.63545404
2COPI coating of Golgi vesicle (GO:0048205)5.63545404
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80169325
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.80169325
5positive regulation by symbiont of host defense response (GO:0052509)4.53772972
6modulation by symbiont of host defense response (GO:0052031)4.53772972
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.53772972
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.53772972
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.53772972
10modulation by symbiont of host immune response (GO:0052553)4.53772972
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.27256825
12antigen processing and presentation of endogenous antigen (GO:0019883)4.20618065
13positive regulation of nuclease activity (GO:0032075)4.18513210
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.03671471
15positive regulation of histone deacetylation (GO:0031065)3.93759198
16negative regulation of cell size (GO:0045792)3.91444742
17positive regulation of CREB transcription factor activity (GO:0032793)3.84517909
18maternal placenta development (GO:0001893)3.82283286
19regulation of nuclease activity (GO:0032069)3.81884698
20protein retention in ER lumen (GO:0006621)3.78836430
21pentose-phosphate shunt (GO:0006098)3.66670381
22detection of bacterium (GO:0016045)3.65855228
23negative regulation of interleukin-6 production (GO:0032715)3.61782058
24detection of other organism (GO:0098543)3.57082659
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.54572356
26endoplasmic reticulum unfolded protein response (GO:0030968)3.53200174
27regulation of translational fidelity (GO:0006450)3.50755245
28response to peptidoglycan (GO:0032494)3.49831384
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48748648
30macrophage activation involved in immune response (GO:0002281)3.47014668
31regulation of early endosome to late endosome transport (GO:2000641)3.46586992
32regulation of interferon-beta biosynthetic process (GO:0045357)3.46133757
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45131151
34tolerance induction (GO:0002507)3.40401218
35negative thymic T cell selection (GO:0045060)3.40391958
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.38570162
37positive regulation of antigen processing and presentation (GO:0002579)3.37958006
38glucocorticoid receptor signaling pathway (GO:0042921)3.35245179
39negative regulation of interleukin-1 production (GO:0032692)3.35233449
40peptidyl-lysine dimethylation (GO:0018027)3.33607797
41response to muramyl dipeptide (GO:0032495)3.32485271
42negative regulation of erythrocyte differentiation (GO:0045647)3.32134236
43cellular response to unfolded protein (GO:0034620)3.31983777
44regulation of antigen processing and presentation (GO:0002577)3.30023926
45regulation of mast cell degranulation (GO:0043304)3.29381325
46positive thymic T cell selection (GO:0045059)3.28399192
47regulation of translational termination (GO:0006449)3.27901693
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27335533
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24650002
50T cell selection (GO:0045058)3.22293950
51negative T cell selection (GO:0043383)3.21382803
52B cell receptor signaling pathway (GO:0050853)3.20083782
53ER-nucleus signaling pathway (GO:0006984)3.18072207
54negative regulation of interleukin-1 beta production (GO:0032691)3.16092610
55heterochromatin organization (GO:0070828)3.15616632
56leukocyte aggregation (GO:0070486)3.14772913
57cellular response to topologically incorrect protein (GO:0035967)3.12110138
58regulation of NFAT protein import into nucleus (GO:0051532)3.11547056
59regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08994644
60regulation of leukocyte degranulation (GO:0043300)3.08200425
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.07394374
62L-alpha-amino acid transmembrane transport (GO:1902475)3.05741973
63NADPH regeneration (GO:0006740)3.05549765
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03954336
65antigen processing and presentation via MHC class Ib (GO:0002475)2.99268875
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.98709564
67detection of external biotic stimulus (GO:0098581)2.97738969
68regulation of chromatin binding (GO:0035561)2.96205256
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.96124638
70negative regulation of RNA splicing (GO:0033119)2.95498898
71apoptotic cell clearance (GO:0043277)2.92897949
72regulation of mast cell activation involved in immune response (GO:0033006)2.92699672
73negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89883180
74negative regulation of cell killing (GO:0031342)2.89883180
75apoptotic process involved in morphogenesis (GO:0060561)2.89579821
76regulation of gamma-delta T cell differentiation (GO:0045586)2.88444614
77negative regulation of T cell mediated immunity (GO:0002710)2.87237598
78cellular extravasation (GO:0045123)2.85150626
79negative regulation of interleukin-12 production (GO:0032695)2.84652824
80positive regulation of mast cell activation (GO:0033005)2.84434363
81regulation of dendritic cell antigen processing and presentation (GO:0002604)2.83507458
82positive regulation of protein deacetylation (GO:0090312)2.81710315
83positive regulation of histone acetylation (GO:0035066)2.81691104
84neutrophil activation involved in immune response (GO:0002283)2.81637511
85germinal center formation (GO:0002467)2.80857355
86sodium ion export (GO:0071436)2.79036081
87vesicle coating (GO:0006901)2.77459493
88DNA unwinding involved in DNA replication (GO:0006268)2.77273869
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76840233
90negative regulation of leukocyte mediated immunity (GO:0002704)2.76438479
91positive regulation of lamellipodium assembly (GO:0010592)2.75836636
92negative regulation of innate immune response (GO:0045824)2.75506131
93RNA stabilization (GO:0043489)2.75436098
94mRNA stabilization (GO:0048255)2.75436098
95positive T cell selection (GO:0043368)2.75218884
96activated T cell proliferation (GO:0050798)2.74440595
97immunoglobulin mediated immune response (GO:0016064)2.74412856
98mannose metabolic process (GO:0006013)2.73448761
99regulation of T cell mediated cytotoxicity (GO:0001914)2.73293862
100regulation of ARF GTPase activity (GO:0032312)2.72863141
101cortical actin cytoskeleton organization (GO:0030866)2.72541900
102regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.72022773
103regulation of mast cell activation (GO:0033003)2.71970742
104intracellular estrogen receptor signaling pathway (GO:0030520)2.71728417
105regulation of protein heterodimerization activity (GO:0043497)2.70746602
106negative regulation of tumor necrosis factor production (GO:0032720)2.69640420
107negative regulation of fatty acid transport (GO:2000192)2.68296844
1083-UTR-mediated mRNA stabilization (GO:0070935)2.67977248
109positive regulation of gamma-delta T cell activation (GO:0046645)2.67424288
110regulation of B cell receptor signaling pathway (GO:0050855)2.67417580
111dosage compensation (GO:0007549)2.66509337
112detection of biotic stimulus (GO:0009595)2.66381186
113corticosteroid receptor signaling pathway (GO:0031958)2.66051330
114positive regulation of protein acetylation (GO:1901985)2.66003854
115positive regulation of peptidyl-lysine acetylation (GO:2000758)2.66003854
116positive regulation of mast cell degranulation (GO:0043306)2.65316581
117positive regulation of mast cell activation involved in immune response (GO:0033008)2.65316581
118response to endoplasmic reticulum stress (GO:0034976)2.65150420
119modulation by virus of host process (GO:0019054)2.63682200
120axon extension involved in axon guidance (GO:0048846)2.63666650
121neuron projection extension involved in neuron projection guidance (GO:1902284)2.63666650
122regulation of regulated secretory pathway (GO:1903305)2.63547587
123folic acid-containing compound biosynthetic process (GO:0009396)2.63212263
124cellular response to exogenous dsRNA (GO:0071360)2.62769219
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62470259
126negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.62343636
127neutrophil activation (GO:0042119)2.61829492
128amyloid precursor protein catabolic process (GO:0042987)2.61694801
129barbed-end actin filament capping (GO:0051016)2.60872148
130protein localization to endosome (GO:0036010)2.60708731
131response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60419670
132response to host immune response (GO:0052572)2.60419670
133regulation of histone phosphorylation (GO:0033127)2.59217920
134stress fiber assembly (GO:0043149)2.58116167
135response to type I interferon (GO:0034340)2.57389330
136planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56938438
137response to laminar fluid shear stress (GO:0034616)2.56857750
138receptor catabolic process (GO:0032801)2.56746051
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56545060
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56525422
141peptidyl-arginine omega-N-methylation (GO:0035247)2.55897325
142negative regulation of mRNA metabolic process (GO:1903312)2.55551674
143positive regulation of RNA splicing (GO:0033120)2.55057212
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.54447758
145positive regulation of defense response to virus by host (GO:0002230)2.53413843
146thymic T cell selection (GO:0045061)2.53069370
147negative regulation of mRNA processing (GO:0050686)2.52940823
148interleukin-1-mediated signaling pathway (GO:0070498)2.52563459
149semaphorin-plexin signaling pathway (GO:0071526)2.52161980
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52025481
151response to host (GO:0075136)2.52025481
152response to host defenses (GO:0052200)2.52025481
153N-acetylneuraminate metabolic process (GO:0006054)2.50620741
154positive regulation of Rap GTPase activity (GO:0032854)2.50596245
155natural killer cell differentiation (GO:0001779)2.50475130
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49931048
157regulation of gamma-delta T cell activation (GO:0046643)2.49818951
158negative regulation of nucleotide catabolic process (GO:0030812)2.49549901
159positive regulation of B cell differentiation (GO:0045579)2.47772837
160microglial cell activation (GO:0001774)2.47564291
161positive regulation of lamellipodium organization (GO:1902745)2.47522657
162detection of molecule of bacterial origin (GO:0032490)2.46507142
163ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.46414810
164positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.46280241
165signal complex assembly (GO:0007172)2.45273129
166lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45237922
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45140800
168positive regulation of natural killer cell differentiation (GO:0032825)2.44512461
169response to protozoan (GO:0001562)2.44420692
170pre-miRNA processing (GO:0031054)2.43966546
171type I interferon signaling pathway (GO:0060337)2.43691403
172cellular response to type I interferon (GO:0071357)2.43691403
173embryonic foregut morphogenesis (GO:0048617)2.42599235
174NLS-bearing protein import into nucleus (GO:0006607)2.42485964
175granulocyte activation (GO:0036230)2.41825966
176negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41483428
177T cell apoptotic process (GO:0070231)2.41396651
178cerebellar Purkinje cell layer development (GO:0021680)2.41180202
179activation of JUN kinase activity (GO:0007257)2.40913859
180protein-DNA complex disassembly (GO:0032986)2.40606560
181nucleosome disassembly (GO:0006337)2.40606560
182mitotic G1 DNA damage checkpoint (GO:0031571)2.40435524
183negative regulation of microtubule polymerization (GO:0031115)2.38648407
184apoptotic process involved in development (GO:1902742)2.37529988
185negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.36049327
186positive regulation of gene expression, epigenetic (GO:0045815)2.35983487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.00717404
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.83433351
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18289810
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.13178127
5VDR_21846776_ChIP-Seq_THP-1_Human3.08414310
6LXR_22292898_ChIP-Seq_THP-1_Human2.57371942
7KDM2B_26808549_Chip-Seq_DND41_Human2.52221830
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.50550215
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47376637
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.46369780
11TCF7_22412390_ChIP-Seq_EML_Mouse2.40908989
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.40586415
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.31388893
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20024999
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.18600423
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.07863170
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06118407
18E2F7_22180533_ChIP-Seq_HELA_Human2.03095537
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01061068
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98089464
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84328213
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82486386
23MAF_26560356_Chip-Seq_TH1_Human1.81507523
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.81267494
25RACK7_27058665_Chip-Seq_MCF-7_Human1.80933925
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80765214
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80713953
28UTX_26944678_Chip-Seq_JUKART_Human1.79178327
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77097837
30VDR_24763502_ChIP-Seq_THP-1_Human1.72962147
31GATA1_19941826_ChIP-Seq_K562_Human1.69050686
32DROSHA_22980978_ChIP-Seq_HELA_Human1.66787997
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65756429
34KDM2B_26808549_Chip-Seq_K562_Human1.63301983
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.61494519
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60805623
37* IRF8_27001747_Chip-Seq_BMDM_Mouse1.54669451
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52824190
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52509861
40CIITA_25753668_ChIP-Seq_RAJI_Human1.52097658
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51902331
42RUNX_20019798_ChIP-Seq_JUKART_Human1.50636451
43P68_20966046_ChIP-Seq_HELA_Human1.50176578
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49925227
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.49849889
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49428526
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46339349
48CLOCK_20551151_ChIP-Seq_293T_Human1.45859436
49ATF3_27146783_Chip-Seq_COLON_Human1.44512376
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43227262
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42678096
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.41603662
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41398686
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39990972
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38975911
56ZNF263_19887448_ChIP-Seq_K562_Human1.38852678
57E2F1_20622854_ChIP-Seq_HELA_Human1.38681022
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37430195
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37119186
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36957141
61SPI1_23127762_ChIP-Seq_K562_Human1.36912473
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34609202
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34331737
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34319223
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34092548
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33060718
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31373852
68CREB1_26743006_Chip-Seq_LNCaP_Human1.31023375
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30879642
70GATA1_22025678_ChIP-Seq_K562_Human1.29796304
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29105523
72SPI1_23547873_ChIP-Seq_NB4_Human1.29062990
73MAF_26560356_Chip-Seq_TH2_Human1.29026912
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28862949
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28793122
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.26645392
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26205610
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25909838
79NCOR1_26117541_ChIP-Seq_K562_Human1.25294656
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.24728939
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24309623
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23451467
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23311072
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22350315
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21654906
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21463001
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21277820
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.20441084
89BCOR_27268052_Chip-Seq_Bcells_Human1.20329911
90SCL_19346495_ChIP-Seq_HPC-7_Human1.20148428
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19677463
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18869703
93TP63_22573176_ChIP-Seq_HFKS_Human1.18219524
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17843029
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17271991
96SMC4_20622854_ChIP-Seq_HELA_Human1.17027503
97SA1_27219007_Chip-Seq_Bcells_Human1.17001620
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15825499
99TP53_22127205_ChIP-Seq_IMR90_Human1.15575099
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13089842
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12878796
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12259201
103BCL6_27268052_Chip-Seq_Bcells_Human1.12141473
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11975153
105XRN2_22483619_ChIP-Seq_HELA_Human1.11025895
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10638602
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10420446
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10388847
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10098219
110* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09787134
111CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09665275
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08776682
113CTCF_20526341_ChIP-Seq_ESCs_Human1.08157438
114VDR_24787735_ChIP-Seq_THP-1_Human1.08019055
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.07776268
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.07187473
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07166237
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07092471
119PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06775365
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06241477
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06204475
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05971894
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05722989
124P300_27268052_Chip-Seq_Bcells_Human1.05583500
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05378993
126PHF8_20622854_ChIP-Seq_HELA_Human1.04741511
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03526435
128NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02837226
129MYB_26560356_Chip-Seq_TH2_Human1.02231255
130CTCF_21964334_Chip-Seq_Bcells_Human1.00568243
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.99409203
132MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99084367
133MYB_26560356_Chip-Seq_TH1_Human0.98776396
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.98347432
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95816088
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95608162
137TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94999643
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94724064
139HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94213603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.60167256
2MP0003303_peritoneal_inflammation3.54821731
3MP0003705_abnormal_hypodermis_morpholog3.35593444
4MP0003300_gastrointestinal_ulcer3.10402996
5MP0005076_abnormal_cell_differentiation3.02814560
6MP0010234_abnormal_vibrissa_follicle2.97165770
7MP0008961_abnormal_basal_metabolism2.70651589
8MP0001835_abnormal_antigen_presentation2.67510389
9MP0003724_increased_susceptibility_to2.59883190
10MP0009278_abnormal_bone_marrow2.58365562
11MP0002419_abnormal_innate_immunity2.53986562
12MP0010352_gastrointestinal_tract_polyps2.43836141
13MP0005025_abnormal_response_to2.43347648
14MP0003172_abnormal_lysosome_physiology2.32822009
15MP0005671_abnormal_response_to2.19562245
16MP0003566_abnormal_cell_adhesion2.12654917
17MP0005058_abnormal_lysosome_morphology2.10776911
18MP0006054_spinal_hemorrhage2.07115337
19MP0002148_abnormal_hypersensitivity_rea1.93126096
20MP0009785_altered_susceptibility_to1.91832850
21MP0004858_abnormal_nervous_system1.89221587
22MP0001849_ear_inflammation1.81464542
23MP0005451_abnormal_body_composition1.73211185
24MP0006082_CNS_inflammation1.66278364
25MP0002234_abnormal_pharynx_morphology1.63848567
26MP0000685_abnormal_immune_system1.63842015
27MP0002933_joint_inflammation1.57981862
28MP0001663_abnormal_digestive_system1.54418536
29MP0002653_abnormal_ependyma_morphology1.51824714
30MP0009840_abnormal_foam_cell1.51079691
31MP0004947_skin_inflammation1.51076981
32MP0002396_abnormal_hematopoietic_system1.51016859
33MP0000537_abnormal_urethra_morphology1.49898248
34MP0008438_abnormal_cutaneous_collagen1.47145912
35MP0001845_abnormal_inflammatory_respons1.43186438
36MP0010307_abnormal_tumor_latency1.38238077
37MP0004510_myositis1.33838407
38MP0003436_decreased_susceptibility_to1.31442934
39MP0002909_abnormal_adrenal_gland1.31037482
40MP0005083_abnormal_biliary_tract1.30953452
41MP0002089_abnormal_postnatal_growth/wei1.30583913
42MP0005023_abnormal_wound_healing1.29326363
43MP0003183_abnormal_peptide_metabolism1.27743308
44MP0002877_abnormal_melanocyte_morpholog1.27227860
45MP0008469_abnormal_protein_level1.25030481
46MP0004381_abnormal_hair_follicle1.24988340
47MP0004808_abnormal_hematopoietic_stem1.22269938
48MP0001730_embryonic_growth_arrest1.21049461
49MP0005390_skeleton_phenotype1.19781952
50MP0003091_abnormal_cell_migration1.19511040
51MP0000733_abnormal_muscle_development1.18648171
52MP0001545_abnormal_hematopoietic_system1.18164435
53MP0005397_hematopoietic_system_phenotyp1.18164435
54MP0003329_amyloid_beta_deposits1.15781582
55MP0002998_abnormal_bone_remodeling1.14931607
56MP0004130_abnormal_muscle_cell1.14586547
57MP0001348_abnormal_lacrimal_gland1.14306250
58MP0004185_abnormal_adipocyte_glucose1.13540500
59MP0009764_decreased_sensitivity_to1.13407073
60MP0005381_digestive/alimentary_phenotyp1.11036143
61MP0000350_abnormal_cell_proliferation1.10288977
62MP0002398_abnormal_bone_marrow1.10147612
63MP0009053_abnormal_anal_canal1.09328044
64MP0000015_abnormal_ear_pigmentation1.09061499
65MP0004197_abnormal_fetal_growth/weight/1.08509668
66MP0003279_aneurysm1.08263033
67MP0001873_stomach_inflammation1.06753266
68MP0001790_abnormal_immune_system1.04976363
69MP0005387_immune_system_phenotype1.04976363
70MP0004859_abnormal_synaptic_plasticity1.04361987
71MP0000703_abnormal_thymus_morphology1.03171543
72MP0000604_amyloidosis1.02431805
73MP0003115_abnormal_respiratory_system1.00470424
74MP0000428_abnormal_craniofacial_morphol0.98730873
75MP0000465_gastrointestinal_hemorrhage0.98537189
76MP0001800_abnormal_humoral_immune0.98511637
77MP0003866_abnormal_defecation0.98045316
78MP0009333_abnormal_splenocyte_physiolog0.97779355
79MP0002132_abnormal_respiratory_system0.97516552
80MP0003828_pulmonary_edema0.97107435
81MP0000858_altered_metastatic_potential0.96971994
82MP0005464_abnormal_platelet_physiology0.96873226
83MP0005220_abnormal_exocrine_pancreas0.95588088
84MP0002452_abnormal_antigen_presenting0.93914395
85MP0000249_abnormal_blood_vessel0.93258155
86MP0000003_abnormal_adipose_tissue0.93231982
87MP0002080_prenatal_lethality0.93162026
88MP0001851_eye_inflammation0.92893161
89MP0000490_abnormal_crypts_of0.92891772
90MP0002084_abnormal_developmental_patter0.92492819
91MP0001958_emphysema0.92004378
92MP0001944_abnormal_pancreas_morphology0.91658564
93MP0000534_abnormal_ureter_morphology0.91524054
94MP0003763_abnormal_thymus_physiology0.90240244
95MP0002722_abnormal_immune_system0.90206709
96MP0002420_abnormal_adaptive_immunity0.87891422
97MP0009672_abnormal_birth_weight0.87836717
98MP0000462_abnormal_digestive_system0.87447650
99MP0001819_abnormal_immune_cell0.87110916
100MP0003075_altered_response_to0.85965315
101MP0005167_abnormal_blood-brain_barrier0.85892382
102MP0000716_abnormal_immune_system0.85504607
103MP0000689_abnormal_spleen_morphology0.84613184
104MP0003119_abnormal_digestive_system0.84586877
105MP0002085_abnormal_embryonic_tissue0.83343542
106MP0010155_abnormal_intestine_physiology0.83240273
107MP0002429_abnormal_blood_cell0.82766284
108MP0004233_abnormal_muscle_weight0.82744762
109MP0000569_abnormal_digit_pigmentation0.82302791
110MP0001986_abnormal_taste_sensitivity0.81967077
111MP0003045_fibrosis0.81773128
112MP0005621_abnormal_cell_physiology0.81680584
113MP0004883_abnormal_blood_vessel0.81346932
114MP0004264_abnormal_extraembryonic_tissu0.81286922
115MP0000477_abnormal_intestine_morphology0.81253108
116MP0001533_abnormal_skeleton_physiology0.79976884
117MP0003123_paternal_imprinting0.79799521
118MP0003453_abnormal_keratinocyte_physiol0.79649389
119MP0002405_respiratory_system_inflammati0.78871988
120MP0002086_abnormal_extraembryonic_tissu0.78861710
121MP0005375_adipose_tissue_phenotype0.78643754
122MP0005164_abnormal_response_to0.78053403
123MP0005310_abnormal_salivary_gland0.77914639
124MP0000767_abnormal_smooth_muscle0.77900609
125MP0008770_decreased_survivor_rate0.77305210
126MP0002723_abnormal_immune_serum0.76936670
127MP0000470_abnormal_stomach_morphology0.76643549
128MP0003191_abnormal_cellular_cholesterol0.75893689
129MP0001697_abnormal_embryo_size0.75552991
130MP0003693_abnormal_embryo_hatching0.75441775
131MP0005000_abnormal_immune_tolerance0.75426569
132MP0002896_abnormal_bone_mineralization0.74143824
133MP0008260_abnormal_autophagy0.73950610
134MP0003638_abnormal_response/metabolism_0.73777186
135MP0003656_abnormal_erythrocyte_physiolo0.73630952
136MP0000371_diluted_coat_color0.72803767
137MP0009931_abnormal_skin_appearance0.69243650
138MP0002277_abnormal_respiratory_mucosa0.68027842
139MP0004043_abnormal_pH_regulation0.67961391
140MP0001664_abnormal_digestion0.67429250
141MP0003795_abnormal_bone_structure0.66803671
142MP0000678_abnormal_parathyroid_gland0.66018254
143MP0000343_altered_response_to0.65520210
144MP0008874_decreased_physiological_sensi0.64572144
145MP0002136_abnormal_kidney_physiology0.61939312

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)3.67591213
2Cerebral aneurysm (HP:0004944)3.65547606
3Global brain atrophy (HP:0002283)3.48862209
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.43228009
5Hyperacusis (HP:0010780)3.39560980
6Abnormality of macrophages (HP:0004311)3.32653210
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.31402505
8Elevated erythrocyte sedimentation rate (HP:0003565)3.28727156
9Recurrent bacterial skin infections (HP:0005406)3.25517885
10Recurrent abscess formation (HP:0002722)3.21717955
11Orchitis (HP:0100796)3.14529733
12Gastrointestinal infarctions (HP:0005244)3.12071358
13Dysostosis multiplex (HP:0000943)3.10166115
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.05905051
15Hand muscle atrophy (HP:0009130)3.04440306
16Recurrent fungal infections (HP:0002841)3.01115414
17Breast hypoplasia (HP:0003187)2.88473804
18Protrusio acetabuli (HP:0003179)2.84729030
19Upper limb amyotrophy (HP:0009129)2.84294864
20Distal upper limb amyotrophy (HP:0007149)2.84294864
21Retrobulbar optic neuritis (HP:0100654)2.76241636
22Optic neuritis (HP:0100653)2.76241636
23Urinary glycosaminoglycan excretion (HP:0003541)2.75663879
24Mucopolysacchariduria (HP:0008155)2.75663879
25Recurrent cutaneous fungal infections (HP:0011370)2.69976943
26Chronic mucocutaneous candidiasis (HP:0002728)2.69976943
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67899166
28Abnormality of polysaccharide metabolism (HP:0011012)2.67899166
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67899166
30Meningitis (HP:0001287)2.61017216
31Gastrointestinal stroma tumor (HP:0100723)2.59952377
32Shallow orbits (HP:0000586)2.59046300
33Birth length less than 3rd percentile (HP:0003561)2.55815459
34Segmental peripheral demyelination/remyelination (HP:0003481)2.54614175
35Pustule (HP:0200039)2.53617180
36Encephalitis (HP:0002383)2.53048374
37Insomnia (HP:0100785)2.51811229
38Obstructive lung disease (HP:0006536)2.50642436
39Chronic obstructive pulmonary disease (HP:0006510)2.50642436
40Vacuolated lymphocytes (HP:0001922)2.45459907
41Genu recurvatum (HP:0002816)2.43949526
42Broad face (HP:0000283)2.42645032
43Recurrent skin infections (HP:0001581)2.38822842
44Mediastinal lymphadenopathy (HP:0100721)2.31877307
45Vasculitis (HP:0002633)2.25916835
46Ankyloglossia (HP:0010296)2.24875821
47Renal duplication (HP:0000075)2.24337692
48Ankle contracture (HP:0006466)2.23174019
49Abnormality of binocular vision (HP:0011514)2.21935297
50Diplopia (HP:0000651)2.21935297
51Neoplasm of the heart (HP:0100544)2.21832355
52Apathy (HP:0000741)2.20470941
53Increased density of long bones (HP:0006392)2.20240662
54Hemorrhage of the eye (HP:0011885)2.19531079
55Stomatitis (HP:0010280)2.19022550
56Macroorchidism (HP:0000053)2.19002087
57Agammaglobulinemia (HP:0004432)2.18623077
58Spontaneous hematomas (HP:0007420)2.16718937
59Bladder diverticulum (HP:0000015)2.16334329
60Bowel diverticulosis (HP:0005222)2.16151784
61Hypochromic anemia (HP:0001931)2.15230436
62Dilatation of the ascending aorta (HP:0005111)2.15185042
63Enlarged penis (HP:0000040)2.14545449
64Diminished motivation (HP:0000745)2.14434075
65Recurrent gram-negative bacterial infections (HP:0005420)2.14135039
66Cellulitis (HP:0100658)2.13741202
67Prolonged bleeding time (HP:0003010)2.12380402
68Elfin facies (HP:0004428)2.12260501
69Abnormality of the thoracic spine (HP:0100711)2.12019867
70Pulmonary infiltrates (HP:0002113)2.10585216
71Ulnar bowing (HP:0003031)2.08941765
72Hemoptysis (HP:0002105)2.08478587
73Urticaria (HP:0001025)2.07737646
74Abnormality of oral frenula (HP:0000190)2.07072576
75Pointed chin (HP:0000307)2.06874446
76Severe short stature (HP:0003510)2.05884039
77Increased serum ferritin (HP:0003281)2.05771945
78Cervical subluxation (HP:0003308)2.05733850
79Mesangial abnormality (HP:0001966)2.04620572
80Recurrent viral infections (HP:0004429)2.04309150
81Ovoid vertebral bodies (HP:0003300)2.02332703
82Ependymoma (HP:0002888)2.01636905
83Hypercortisolism (HP:0001578)2.00791458
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00209162
85Short 4th metacarpal (HP:0010044)2.00209162
86Premature rupture of membranes (HP:0001788)1.99953494
87Achilles tendon contracture (HP:0001771)1.99418393
88Long toe (HP:0010511)1.99400240
89Increased cerebral lipofuscin (HP:0011813)1.96991358
90Aneurysm (HP:0002617)1.96581082
91Amyloidosis (HP:0011034)1.96432687
92Clumsiness (HP:0002312)1.96269654
93Flat acetabular roof (HP:0003180)1.95395526
94Lymphangioma (HP:0100764)1.94724304
95Polycythemia (HP:0001901)1.93626751
96Mitral valve prolapse (HP:0001634)1.93016299
97Hallux valgus (HP:0001822)1.91277903
98Recurrent bronchitis (HP:0002837)1.90863082
99Gingivitis (HP:0000230)1.89151166
100Deviation of the hallux (HP:0010051)1.89016772
101Abnormality of the lower motor neuron (HP:0002366)1.88783066
102Keratoconjunctivitis sicca (HP:0001097)1.88663536
103Broad palm (HP:0001169)1.88619813
104Panhypogammaglobulinemia (HP:0003139)1.88080209
105Cheilitis (HP:0100825)1.87917500
106Aortic aneurysm (HP:0004942)1.87734778
107Abnormality of the fingertips (HP:0001211)1.87568817
108Peritonitis (HP:0002586)1.87388923
109Gastrointestinal inflammation (HP:0004386)1.87148782
110Eczematoid dermatitis (HP:0000976)1.86977043
111Interstitial pulmonary disease (HP:0006530)1.86808174
112Deep palmar crease (HP:0006191)1.84605131
113Verrucae (HP:0200043)1.82628611
114Papilloma (HP:0012740)1.82628611
115Coxa vara (HP:0002812)1.82594612
116Joint stiffness (HP:0001387)1.82499043
117Overriding aorta (HP:0002623)1.81618134
118Posterior subcapsular cataract (HP:0007787)1.81349001
119Keratoconjunctivitis (HP:0001096)1.81291575
120Disproportionate tall stature (HP:0001519)1.81137143
121Nasal polyposis (HP:0100582)1.80985604
122Abnormality of glycolipid metabolism (HP:0010969)1.80945246
123Abnormality of liposaccharide metabolism (HP:0010968)1.80945246
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.80945246
125Abnormality of the nasal mucosa (HP:0000433)1.80785940
126J-shaped sella turcica (HP:0002680)1.79930802
127Chronic otitis media (HP:0000389)1.79907911
128Flat cornea (HP:0007720)1.79600401
129Striae distensae (HP:0001065)1.78977447
130Broad metatarsal (HP:0001783)1.78809152
131Abnormality of iron homeostasis (HP:0011031)1.77840691
132Abnormality of T cell physiology (HP:0011840)1.77610898
133Hypertensive crisis (HP:0100735)1.77481449
134Restrictive lung disease (HP:0002091)1.77078181
135Supranuclear gaze palsy (HP:0000605)1.76646804
136Neurodegeneration (HP:0002180)1.76345786
137Loss of speech (HP:0002371)1.76161476
138Abnormality of the Achilles tendon (HP:0005109)1.75639839
139Renovascular hypertension (HP:0100817)1.75367979
140Turricephaly (HP:0000262)1.74713446
141Polygenic inheritance (HP:0010982)1.74593142
142Large for gestational age (HP:0001520)1.74457626
143Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74012324
144Increased IgE level (HP:0003212)1.72373245
145Microretrognathia (HP:0000308)1.71988576
146Cardiomegaly (HP:0001640)1.71741753
147Fatigue (HP:0012378)1.71690039
148Spondylolisthesis (HP:0003302)1.69226433
149Onion bulb formation (HP:0003383)1.68925742
150Metaphyseal cupping (HP:0003021)1.68466927
151Astrocytoma (HP:0009592)1.68235961
152Abnormality of the astrocytes (HP:0100707)1.68235961
153Annular pancreas (HP:0001734)1.67978437
154Thin bony cortex (HP:0002753)1.66860199
155Colitis (HP:0002583)1.65403775
156Emphysema (HP:0002097)1.65402898
157Thoracolumbar scoliosis (HP:0002944)1.65109444
158Deformed sella turcica (HP:0002681)1.64797286
159Thoracic kyphosis (HP:0002942)1.64743288
160Spinal muscular atrophy (HP:0007269)1.60455468
161Lumbar hyperlordosis (HP:0002938)1.60389512
162Short phalanx of the thumb (HP:0009660)1.59761878
163Long palpebral fissure (HP:0000637)1.58247428
164Cerebral inclusion bodies (HP:0100314)1.58157481
165Adenoma sebaceum (HP:0009720)1.57907410
166Angiofibromas (HP:0010615)1.57907410
167Abnormality of the motor neurons (HP:0002450)1.56894654
168Abnormal neuron morphology (HP:0012757)1.56894654
169Atrophy/Degeneration involving motor neurons (HP:0007373)1.56881627
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56792215
171Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55940006
172Inflammation of the large intestine (HP:0002037)1.55483747
173Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.54916761
174Papilledema (HP:0001085)1.54811965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.92333924
2ERN14.40221444
3MAP3K103.65271916
4EEF2K3.49697700
5PKN23.28000615
6RIPK43.22474679
7PRPF4B2.40837015
8IRAK42.37133868
9TAOK32.34100579
10MAP4K12.10485305
11PTK61.97549915
12ICK1.83265373
13SCYL21.83234937
14SIK11.82658561
15RIPK11.76735723
16CDK121.74631627
17TAOK11.62595026
18PDGFRA1.58624441
19LRRK21.57979477
20GRK61.54194210
21TNK21.51187897
22MAP3K131.50930145
23SMG11.50465295
24KSR21.49442644
25PAK41.49258135
26TESK21.47414623
27ALK1.35495165
28SIK21.31663888
29MAPK151.31221376
30MAP3K91.29306265
31PASK1.23541958
32IRAK31.23462121
33MAP3K141.21987739
34STK101.21855670
35FGFR41.20846705
36BMX1.20582896
37EPHB11.20471300
38DDR21.18489913
39TYRO31.17817539
40EPHB21.15939417
41KSR11.12905396
42DAPK21.12020485
43MTOR1.07085877
44INSRR1.04850526
45RPS6KA61.02441186
46TBK11.00889136
47TESK10.99376576
48NEK20.99100850
49TTN0.97318767
50PRKD30.96647012
51NTRK10.96056173
52PTK20.96012445
53PDPK10.93762202
54HIPK20.92976593
55CAMKK20.92675787
56MAP3K30.91563455
57ZAP700.91514336
58SIK30.87899558
59TYK20.87286440
60CSF1R0.86600388
61CAMKK10.85841784
62IKBKB0.85655803
63RET0.85653077
64CAMK1D0.85405041
65MAP3K80.83804474
66PTK2B0.83367128
67MAPK120.82353923
68DYRK1B0.82227929
69MAP3K60.79579666
70IKBKE0.79239306
71MAP2K60.79079757
72LCK0.78381249
73WNK40.78272945
74PAK20.77037334
75PDK10.76732281
76LYN0.74810691
77TGFBR20.74407474
78EPHA20.74379253
79FGR0.73377818
80BTK0.73129358
81RPS6KL10.70571726
82RPS6KC10.70571726
83MATK0.69599981
84PAK60.68284842
85FES0.67873522
86PRKCH0.67805435
87MAP3K110.67191701
88MAP2K10.67011059
89HCK0.66645696
90IRAK10.65514354
91ADRBK20.65503330
92CSK0.65279401
93JAK30.63933438
94MAPK70.63414736
95BLK0.62315990
96ACVR1B0.61203497
97PRKG20.59238159
98NEK90.58270709
99UHMK10.56337923
100ILK0.56059671
101JAK10.55291344
102FLT30.54228932
103PDGFRB0.54169278
104JAK20.53980156
105MAP2K20.53588682
106MARK30.53439961
107CDK40.52944722
108MAP3K10.52552909
109RPS6KA40.52471873
110MAPKAPK20.52318436
111RPS6KA20.52204132
112MARK20.51861036
113EPHA30.51734603
114MAP3K70.51318531
115LATS20.51273203
116MAPKAPK30.50757377
117NEK10.50410654
118CAMK1G0.49334402
119PRKD20.48913877
120SYK0.48665736
121ITK0.47577470
122MAP2K30.47141973
123TRPM70.45008615
124FGFR10.43905296
125PRKCQ0.42157859
126CLK10.42051873
127DMPK0.41052440
128MAP3K20.40614644
129TSSK60.40460983
130RPS6KA10.39643460
131CDK60.39082349
132CDC42BPA0.37375639
133BRD40.36964349
134KIT0.36455297
135SRC0.35145186
136TGFBR10.34825201
137MINK10.34595067
138DAPK10.33621755
139PRKD10.33230220
140MAPK110.33046425
141NTRK20.32898403
142CHUK0.32304264

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.27408771
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.14268592
3Staphylococcus aureus infection_Homo sapiens_hsa051501.94978987
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90014182
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.86751722
6B cell receptor signaling pathway_Homo sapiens_hsa046621.81547369
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78641090
8Notch signaling pathway_Homo sapiens_hsa043301.77151417
9Allograft rejection_Homo sapiens_hsa053301.75955899
10Graft-versus-host disease_Homo sapiens_hsa053321.70573857
11Neurotrophin signaling pathway_Homo sapiens_hsa047221.69755551
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.69196636
13VEGF signaling pathway_Homo sapiens_hsa043701.68701126
14* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68092210
15Autoimmune thyroid disease_Homo sapiens_hsa053201.63469373
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62415069
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61484671
18mTOR signaling pathway_Homo sapiens_hsa041501.61338233
19N-Glycan biosynthesis_Homo sapiens_hsa005101.57667336
20Acute myeloid leukemia_Homo sapiens_hsa052211.53901130
21Non-small cell lung cancer_Homo sapiens_hsa052231.50020105
22Glioma_Homo sapiens_hsa052141.47971481
23Bladder cancer_Homo sapiens_hsa052191.47186334
24Asthma_Homo sapiens_hsa053101.46967932
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44433635
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.44223843
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42295876
28Pancreatic cancer_Homo sapiens_hsa052121.38581851
29Lysosome_Homo sapiens_hsa041421.38075456
30Endometrial cancer_Homo sapiens_hsa052131.37605936
31Osteoclast differentiation_Homo sapiens_hsa043801.34630179
32Colorectal cancer_Homo sapiens_hsa052101.33228135
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31714354
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31611629
35Leishmaniasis_Homo sapiens_hsa051401.29450334
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.27284266
37Antigen processing and presentation_Homo sapiens_hsa046121.27186563
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26840176
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24087999
40Proteoglycans in cancer_Homo sapiens_hsa052051.19901579
41Type II diabetes mellitus_Homo sapiens_hsa049301.19818802
42Shigellosis_Homo sapiens_hsa051311.14426080
43Small cell lung cancer_Homo sapiens_hsa052221.12355131
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.09048533
45Malaria_Homo sapiens_hsa051441.08438273
46* Estrogen signaling pathway_Homo sapiens_hsa049151.06297442
47T cell receptor signaling pathway_Homo sapiens_hsa046601.05772664
48Apoptosis_Homo sapiens_hsa042101.05184725
49Toxoplasmosis_Homo sapiens_hsa051451.04184433
50Renal cell carcinoma_Homo sapiens_hsa052111.04058539
51Hematopoietic cell lineage_Homo sapiens_hsa046401.03424536
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01926552
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01353829
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00755930
55Insulin resistance_Homo sapiens_hsa049310.98867470
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98675600
57Prolactin signaling pathway_Homo sapiens_hsa049170.97192595
58Type I diabetes mellitus_Homo sapiens_hsa049400.97142488
59Endocytosis_Homo sapiens_hsa041440.97113837
60HTLV-I infection_Homo sapiens_hsa051660.96810003
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95460838
62MicroRNAs in cancer_Homo sapiens_hsa052060.94956013
63Hepatitis C_Homo sapiens_hsa051600.94096893
64* Hepatitis B_Homo sapiens_hsa051610.93837167
65Focal adhesion_Homo sapiens_hsa045100.93451878
66ABC transporters_Homo sapiens_hsa020100.92303202
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.91425964
68Amoebiasis_Homo sapiens_hsa051460.91364385
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90563347
70GnRH signaling pathway_Homo sapiens_hsa049120.90361230
71Viral myocarditis_Homo sapiens_hsa054160.89939014
72Phagosome_Homo sapiens_hsa041450.89426688
73Lysine degradation_Homo sapiens_hsa003100.86231999
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85657058
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85176614
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84891101
77Insulin signaling pathway_Homo sapiens_hsa049100.84794656
78Prion diseases_Homo sapiens_hsa050200.84626603
79Tuberculosis_Homo sapiens_hsa051520.84364132
80Other glycan degradation_Homo sapiens_hsa005110.83453905
81Chemokine signaling pathway_Homo sapiens_hsa040620.82695122
82Thyroid cancer_Homo sapiens_hsa052160.82387653
83African trypanosomiasis_Homo sapiens_hsa051430.81772122
84ErbB signaling pathway_Homo sapiens_hsa040120.81286568
85Legionellosis_Homo sapiens_hsa051340.80060163
86* Viral carcinogenesis_Homo sapiens_hsa052030.79569324
87Basal cell carcinoma_Homo sapiens_hsa052170.78540602
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.78201546
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77954559
90Platelet activation_Homo sapiens_hsa046110.77895454
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75880510
92Herpes simplex infection_Homo sapiens_hsa051680.75377962
93Hippo signaling pathway_Homo sapiens_hsa043900.73345361
94HIF-1 signaling pathway_Homo sapiens_hsa040660.73008966
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.72820810
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.71988925
97Rheumatoid arthritis_Homo sapiens_hsa053230.69711640
98Adherens junction_Homo sapiens_hsa045200.69671252
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69517642
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69410815
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68556143
102Primary immunodeficiency_Homo sapiens_hsa053400.68313642
103Dorso-ventral axis formation_Homo sapiens_hsa043200.68249993
104Pertussis_Homo sapiens_hsa051330.66079142
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65383777
106Influenza A_Homo sapiens_hsa051640.64304623
107* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64303860
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.64214066
109Linoleic acid metabolism_Homo sapiens_hsa005910.63971657
110* TNF signaling pathway_Homo sapiens_hsa046680.63338538
111Measles_Homo sapiens_hsa051620.62824642
112AMPK signaling pathway_Homo sapiens_hsa041520.61624678
113MAPK signaling pathway_Homo sapiens_hsa040100.61493027
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.60777753
115Choline metabolism in cancer_Homo sapiens_hsa052310.60704835
116Gap junction_Homo sapiens_hsa045400.60434886
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60233851
118Salmonella infection_Homo sapiens_hsa051320.57989126
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57579856
120Pathways in cancer_Homo sapiens_hsa052000.57209744
121Hedgehog signaling pathway_Homo sapiens_hsa043400.57146761
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56226938
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55786880
124Epstein-Barr virus infection_Homo sapiens_hsa051690.55458309
125Rap1 signaling pathway_Homo sapiens_hsa040150.55100282
126Prostate cancer_Homo sapiens_hsa052150.54893064
127Ether lipid metabolism_Homo sapiens_hsa005650.53296403
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.53237340
129Protein digestion and absorption_Homo sapiens_hsa049740.52347653
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.51940872
131Inositol phosphate metabolism_Homo sapiens_hsa005620.50477069
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49548317
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48274233
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46327224
135FoxO signaling pathway_Homo sapiens_hsa040680.41065839
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.39996930
137Fructose and mannose metabolism_Homo sapiens_hsa000510.39688006
138Gastric acid secretion_Homo sapiens_hsa049710.39481537
139Ovarian steroidogenesis_Homo sapiens_hsa049130.36870330
140Cholinergic synapse_Homo sapiens_hsa047250.36087753

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