

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 3.43099997 |
| 2 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.31624263 |
| 3 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 3.22502368 |
| 4 | negative regulation of granulocyte differentiation (GO:0030853) | 3.19906593 |
| 5 | histone H3-K4 trimethylation (GO:0080182) | 3.14521726 |
| 6 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.09251431 |
| 7 | glomerular filtration (GO:0003094) | 3.04912726 |
| 8 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.01430949 |
| 9 | mannose metabolic process (GO:0006013) | 2.97385477 |
| 10 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.93206150 |
| 11 | negative regulation of stress fiber assembly (GO:0051497) | 2.87112438 |
| 12 | positive regulation of histone deacetylation (GO:0031065) | 2.82830604 |
| 13 | stress fiber assembly (GO:0043149) | 2.82289498 |
| 14 | mitotic sister chromatid cohesion (GO:0007064) | 2.81942917 |
| 15 | renal filtration (GO:0097205) | 2.81426836 |
| 16 | histone H3-K4 methylation (GO:0051568) | 2.80303098 |
| 17 | coronary vasculature morphogenesis (GO:0060977) | 2.77648674 |
| 18 | growth hormone receptor signaling pathway (GO:0060396) | 2.77491101 |
| 19 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.77279920 |
| 20 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.77279920 |
| 21 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.77279920 |
| 22 | definitive hemopoiesis (GO:0060216) | 2.75623127 |
| 23 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.72837828 |
| 24 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.72835477 |
| 25 | positive regulation of granulocyte differentiation (GO:0030854) | 2.72178484 |
| 26 | regulation of p38MAPK cascade (GO:1900744) | 2.71062858 |
| 27 | regulation of T cell tolerance induction (GO:0002664) | 2.70257364 |
| 28 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) | 2.66972244 |
| 29 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO | 2.66972244 |
| 30 | regulation of integrin-mediated signaling pathway (GO:2001044) | 2.64946550 |
| 31 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.64907018 |
| 32 | basement membrane organization (GO:0071711) | 2.64358632 |
| 33 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.63955675 |
| 34 | bone trabecula formation (GO:0060346) | 2.63538383 |
| 35 | embryonic camera-type eye morphogenesis (GO:0048596) | 2.61427924 |
| 36 | negative regulation of complement activation (GO:0045916) | 2.61373424 |
| 37 | cell volume homeostasis (GO:0006884) | 2.61149079 |
| 38 | regulation of histone H3-K27 methylation (GO:0061085) | 2.57360742 |
| 39 | protein heterotrimerization (GO:0070208) | 2.56315403 |
| 40 | vascular endothelial growth factor signaling pathway (GO:0038084) | 2.56270778 |
| 41 | angiogenesis involved in wound healing (GO:0060055) | 2.55589979 |
| 42 | extracellular fibril organization (GO:0043206) | 2.55226940 |
| 43 | venous blood vessel morphogenesis (GO:0048845) | 2.55186631 |
| 44 | surfactant homeostasis (GO:0043129) | 2.54516660 |
| 45 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.53916328 |
| 46 | regulation of integrin activation (GO:0033623) | 2.53862364 |
| 47 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.52633891 |
| 48 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.52633891 |
| 49 | blood vessel maturation (GO:0001955) | 2.52338010 |
| 50 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.51796177 |
| 51 | cellular extravasation (GO:0045123) | 2.49594222 |
| 52 | positive regulation of B cell differentiation (GO:0045579) | 2.48552385 |
| 53 | regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043 | 2.48302961 |
| 54 | heart morphogenesis (GO:0003007) | 2.47462123 |
| 55 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.46704050 |
| 56 | radial glial cell differentiation (GO:0060019) | 2.46094792 |
| 57 | positive regulation by symbiont of host defense response (GO:0052509) | 2.46089318 |
| 58 | modulation by symbiont of host defense response (GO:0052031) | 2.46089318 |
| 59 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.46089318 |
| 60 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.46089318 |
| 61 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.46089318 |
| 62 | modulation by symbiont of host immune response (GO:0052553) | 2.46089318 |
| 63 | peptide cross-linking (GO:0018149) | 2.44661134 |
| 64 | collagen fibril organization (GO:0030199) | 2.44285929 |
| 65 | cell-substrate adherens junction assembly (GO:0007045) | 2.44139170 |
| 66 | focal adhesion assembly (GO:0048041) | 2.44139170 |
| 67 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.42887216 |
| 68 | skin morphogenesis (GO:0043589) | 2.42817022 |
| 69 | extracellular matrix assembly (GO:0085029) | 2.42751840 |
| 70 | fibril organization (GO:0097435) | 2.42459212 |
| 71 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 2.42188592 |
| 72 | face morphogenesis (GO:0060325) | 2.41509849 |
| 73 | hypotonic response (GO:0006971) | 2.40916830 |
| 74 | positive regulation of extracellular matrix organization (GO:1903055) | 2.39878068 |
| 75 | cell-substrate junction assembly (GO:0007044) | 2.38630573 |
| 76 | embryonic hemopoiesis (GO:0035162) | 2.38123962 |
| 77 | cellular response to growth hormone stimulus (GO:0071378) | 2.37083980 |
| 78 | myofibril assembly (GO:0030239) | 2.36463900 |
| 79 | embryonic placenta development (GO:0001892) | 2.36005879 |
| 80 | positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360 | 2.35653767 |
| 81 | gland morphogenesis (GO:0022612) | 2.35334828 |
| 82 | germ cell migration (GO:0008354) | 2.31955433 |
| 83 | axon extension involved in axon guidance (GO:0048846) | 2.31290868 |
| 84 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.31290868 |
| 85 | phagocytosis, recognition (GO:0006910) | 2.30529553 |
| 86 | interleukin-6-mediated signaling pathway (GO:0070102) | 2.29937343 |
| 87 | chondroitin sulfate catabolic process (GO:0030207) | 2.29676655 |
| 88 | cellular response to epinephrine stimulus (GO:0071872) | 2.29528021 |
| 89 | negative regulation of protein activation cascade (GO:2000258) | 2.29478537 |
| 90 | hemidesmosome assembly (GO:0031581) | 2.26825477 |
| 91 | regulation of phospholipase A2 activity (GO:0032429) | 2.26070871 |
| 92 | negative regulation of actin filament bundle assembly (GO:0032232) | 2.25787821 |
| 93 | regulation of B cell differentiation (GO:0045577) | 2.24308221 |
| 94 | cell migration involved in heart development (GO:0060973) | 2.24277509 |
| 95 | membrane raft organization (GO:0031579) | 2.24148562 |
| 96 | positive regulation of mRNA catabolic process (GO:0061014) | 2.23216571 |
| 97 | regulation of gamma-delta T cell activation (GO:0046643) | 2.22943927 |
| 98 | adherens junction assembly (GO:0034333) | 2.22278444 |
| 99 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.22262028 |
| 100 | I-kappaB phosphorylation (GO:0007252) | 2.22142851 |
| 101 | endothelium development (GO:0003158) | 2.22063277 |
| 102 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.21750786 |
| 103 | keratan sulfate catabolic process (GO:0042340) | 2.20379919 |
| 104 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.20262130 |
| 105 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.19820222 |
| 106 | regulation of histone deacetylation (GO:0031063) | 2.19815351 |
| 107 | negative regulation of interleukin-8 production (GO:0032717) | 2.19484022 |
| 108 | embryonic eye morphogenesis (GO:0048048) | 2.18988638 |
| 109 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.18721528 |
| 110 | COPII vesicle coating (GO:0048208) | 2.18448643 |
| 111 | NLS-bearing protein import into nucleus (GO:0006607) | 2.18096347 |
| 112 | negative regulation of smooth muscle cell proliferation (GO:0048662) | 2.17800446 |
| 113 | response to host defenses (GO:0052200) | 2.17473165 |
| 114 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.17473165 |
| 115 | response to host (GO:0075136) | 2.17473165 |
| 116 | germinal center formation (GO:0002467) | 2.17362402 |
| 117 | anatomical structure regression (GO:0060033) | 2.16029684 |
| 118 | barbed-end actin filament capping (GO:0051016) | 2.15928492 |
| 119 | mesodermal cell differentiation (GO:0048333) | 2.15801140 |
| 120 | bone morphogenesis (GO:0060349) | 2.15617863 |
| 121 | phagocytosis, engulfment (GO:0006911) | 2.15046065 |
| 122 | interkinetic nuclear migration (GO:0022027) | 2.14692842 |
| 123 | smooth muscle cell differentiation (GO:0051145) | 2.14452115 |
| 124 | fibroblast migration (GO:0010761) | 2.13368063 |
| 125 | positive regulation of protein import into nucleus, translocation (GO:0033160) | 2.13351002 |
| 126 | regulation of ARF GTPase activity (GO:0032312) | 2.13026477 |
| 127 | regulation of branching involved in salivary gland morphogenesis (GO:0060693) | 2.12841607 |
| 128 | regulation of granulocyte differentiation (GO:0030852) | 2.12834499 |
| 129 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.11780268 |
| 130 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.11616410 |
| 131 | embryonic viscerocranium morphogenesis (GO:0048703) | 2.11399630 |
| 132 | negative regulation of protein localization to cell surface (GO:2000009) | 2.10337370 |
| 133 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.10208236 |
| 134 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.09701343 |
| 135 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.09431167 |
| 136 | hematopoietic stem cell differentiation (GO:0060218) | 2.08804662 |
| 137 | positive regulation of p38MAPK cascade (GO:1900745) | 2.08770880 |
| 138 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.08492641 |
| 139 | import into cell (GO:0098657) | 2.07602281 |
| 140 | endodermal cell differentiation (GO:0035987) | 2.07458125 |
| 141 | positive regulation of odontogenesis (GO:0042482) | 2.07289653 |
| 142 | negative regulation of humoral immune response (GO:0002921) | 2.07161215 |
| 143 | histone H3-K36 demethylation (GO:0070544) | 2.06947059 |
| 144 | B cell homeostasis (GO:0001782) | 2.06334279 |
| 145 | lymph vessel development (GO:0001945) | 2.05960302 |
| 146 | regulation of macrophage cytokine production (GO:0010935) | 2.05816861 |
| 147 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.05683209 |
| 148 | negative regulation of bone mineralization (GO:0030502) | 2.05623952 |
| 149 | metanephric mesenchyme development (GO:0072075) | 2.05203500 |
| 150 | response to fluid shear stress (GO:0034405) | 2.05059055 |
| 151 | pathway-restricted SMAD protein phosphorylation (GO:0060389) | 2.04615956 |
| 152 | endothelial cell chemotaxis (GO:0035767) | 2.04465138 |
| 153 | negative regulation of fatty acid transport (GO:2000192) | 2.04424710 |
| 154 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.04276347 |
| 155 | apoptotic cell clearance (GO:0043277) | 2.04245289 |
| 156 | smooth muscle tissue development (GO:0048745) | 2.04156274 |
| 157 | SMAD protein complex assembly (GO:0007183) | 2.04146638 |
| 158 | response to epinephrine (GO:0071871) | 2.03985875 |
| 159 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 2.03703018 |
| 160 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.03623256 |
| 161 | response to host immune response (GO:0052572) | 2.03623256 |
| 162 | somatic stem cell division (GO:0048103) | 2.02538388 |
| 163 | glomerular basement membrane development (GO:0032836) | 2.02243468 |
| 164 | detection of molecule of bacterial origin (GO:0032490) | 2.02052723 |
| 165 | iron ion import (GO:0097286) | 2.01103195 |
| 166 | regulation of extracellular matrix disassembly (GO:0010715) | 2.01040987 |
| 167 | regulation of establishment of planar polarity (GO:0090175) | 2.00719813 |
| 168 | protein targeting to plasma membrane (GO:0072661) | 2.00674485 |
| 169 | histone lysine methylation (GO:0034968) | 2.00566453 |
| 170 | negative regulation of biomineral tissue development (GO:0070168) | 2.00453713 |
| 171 | negative regulation of neural precursor cell proliferation (GO:2000178) | 1.99387932 |
| 172 | regulation of cell migration involved in sprouting angiogenesis (GO:0090049) | 1.98456251 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.80398114 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.47886878 |
| 3 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.99015099 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.89896270 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.85350155 |
| 6 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.55297684 |
| 7 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.45302000 |
| 8 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.39336008 |
| 9 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.05149218 |
| 10 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.03081917 |
| 11 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.00716836 |
| 12 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.00430452 |
| 13 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.93132997 |
| 14 | GATA1_22025678_ChIP-Seq_K562_Human | 1.85836573 |
| 15 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.85538908 |
| 16 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.85052320 |
| 17 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.84382933 |
| 18 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.84313273 |
| 19 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.79343007 |
| 20 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.75032527 |
| 21 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.74836948 |
| 22 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.74744974 |
| 23 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.73128848 |
| 24 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.71335043 |
| 25 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.70975019 |
| 26 | * SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.70474650 |
| 27 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.69668198 |
| 28 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.64833767 |
| 29 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.62553212 |
| 30 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.61974944 |
| 31 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.61793015 |
| 32 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.57804774 |
| 33 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.56733797 |
| 34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.52808477 |
| 35 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.51570086 |
| 36 | * CJUN_26792858_Chip-Seq_BT549_Human | 1.49576505 |
| 37 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.49005525 |
| 38 | MYC_22102868_ChIP-Seq_BL_Human | 1.45862553 |
| 39 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.42671348 |
| 40 | GATA1_19941826_ChIP-Seq_K562_Human | 1.42079677 |
| 41 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.39290275 |
| 42 | SPI1_23127762_ChIP-Seq_K562_Human | 1.39217482 |
| 43 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.38754356 |
| 44 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.36574411 |
| 45 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.36553090 |
| 46 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.36429361 |
| 47 | TP53_16413492_ChIP-PET_HCT116_Human | 1.35858753 |
| 48 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.34769542 |
| 49 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.33458312 |
| 50 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.33458312 |
| 51 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.33024943 |
| 52 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.32804358 |
| 53 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.32720040 |
| 54 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.32641014 |
| 55 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.32142731 |
| 56 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.32060524 |
| 57 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.31000176 |
| 58 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.30130279 |
| 59 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.29999961 |
| 60 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.29701797 |
| 61 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.28603523 |
| 62 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.27143208 |
| 63 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.25243035 |
| 64 | GATA2_19941826_ChIP-Seq_K562_Human | 1.24993285 |
| 65 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.24683619 |
| 66 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.23604682 |
| 67 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.18328199 |
| 68 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.17769630 |
| 69 | MAF_26560356_Chip-Seq_TH1_Human | 1.16886194 |
| 70 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.16562437 |
| 71 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.16129430 |
| 72 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.16094278 |
| 73 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.15897326 |
| 74 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.15033537 |
| 75 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.14223741 |
| 76 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.13545680 |
| 77 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.13485919 |
| 78 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.13099233 |
| 79 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.12822322 |
| 80 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.12608231 |
| 81 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.12605957 |
| 82 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.12147671 |
| 83 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 1.11970795 |
| 84 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.11912197 |
| 85 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.10959408 |
| 86 | MYB_26560356_Chip-Seq_TH1_Human | 1.10433558 |
| 87 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.10145425 |
| 88 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.09335300 |
| 89 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.08928146 |
| 90 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.07509362 |
| 91 | MYB_26560356_Chip-Seq_TH2_Human | 1.06859473 |
| 92 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.06344373 |
| 93 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.05591260 |
| 94 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.05401768 |
| 95 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.05401768 |
| 96 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.04657304 |
| 97 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.04319081 |
| 98 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.03710885 |
| 99 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.03575326 |
| 100 | UTX_26944678_Chip-Seq_JUKART_Human | 1.02218491 |
| 101 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.02019538 |
| 102 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.01782752 |
| 103 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.01624804 |
| 104 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.01543669 |
| 105 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.00875691 |
| 106 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.00829305 |
| 107 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.00761263 |
| 108 | KDM2B_26808549_Chip-Seq_K562_Human | 0.99094853 |
| 109 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.97464252 |
| 110 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97092279 |
| 111 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.97030399 |
| 112 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.96821935 |
| 113 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.95666406 |
| 114 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.95215921 |
| 115 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.94405564 |
| 116 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.94074222 |
| 117 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.93494330 |
| 118 | RXR_22108803_ChIP-Seq_LS180_Human | 0.93279458 |
| 119 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.91255966 |
| 120 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.89721347 |
| 121 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.89438381 |
| 122 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.88270555 |
| 123 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.86839925 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 3.60083579 |
| 2 | MP0005503_abnormal_tendon_morphology | 2.83471157 |
| 3 | MP0000569_abnormal_digit_pigmentation | 2.66184121 |
| 4 | MP0008004_abnormal_stomach_pH | 2.25618901 |
| 5 | MP0003705_abnormal_hypodermis_morpholog | 2.22842415 |
| 6 | MP0005275_abnormal_skin_tensile | 2.22190234 |
| 7 | MP0003045_fibrosis | 2.21131320 |
| 8 | MP0003279_aneurysm | 2.11505788 |
| 9 | MP0005409_darkened_coat_color | 2.07306523 |
| 10 | MP0005076_abnormal_cell_differentiation | 2.03301198 |
| 11 | MP0004036_abnormal_muscle_relaxation | 1.97713558 |
| 12 | MP0010368_abnormal_lymphatic_system | 1.95772129 |
| 13 | MP0009278_abnormal_bone_marrow | 1.91393052 |
| 14 | MP0003300_gastrointestinal_ulcer | 1.91323293 |
| 15 | MP0002396_abnormal_hematopoietic_system | 1.88569688 |
| 16 | MP0003828_pulmonary_edema | 1.87640540 |
| 17 | MP0002166_altered_tumor_susceptibility | 1.85884593 |
| 18 | MP0006138_congestive_heart_failure | 1.78167249 |
| 19 | MP0005451_abnormal_body_composition | 1.75766015 |
| 20 | MP0003566_abnormal_cell_adhesion | 1.72911355 |
| 21 | MP0000749_muscle_degeneration | 1.71925336 |
| 22 | MP0002060_abnormal_skin_morphology | 1.62242808 |
| 23 | MP0004272_abnormal_basement_membrane | 1.61061110 |
| 24 | MP0002108_abnormal_muscle_morphology | 1.58684451 |
| 25 | MP0000733_abnormal_muscle_development | 1.55312861 |
| 26 | MP0004808_abnormal_hematopoietic_stem | 1.53725228 |
| 27 | MP0005257_abnormal_intraocular_pressure | 1.50586255 |
| 28 | MP0001879_abnormal_lymphatic_vessel | 1.46171265 |
| 29 | MP0001958_emphysema | 1.45971735 |
| 30 | MP0000767_abnormal_smooth_muscle | 1.43737724 |
| 31 | MP0005058_abnormal_lysosome_morphology | 1.42393943 |
| 32 | MP0002006_tumorigenesis | 1.42163690 |
| 33 | MP0001851_eye_inflammation | 1.41968711 |
| 34 | MP0005670_abnormal_white_adipose | 1.38773872 |
| 35 | MP0010030_abnormal_orbit_morphology | 1.37867769 |
| 36 | MP0003191_abnormal_cellular_cholesterol | 1.37245086 |
| 37 | MP0004233_abnormal_muscle_weight | 1.36529329 |
| 38 | MP0009780_abnormal_chondrocyte_physiolo | 1.36126464 |
| 39 | MP0005508_abnormal_skeleton_morphology | 1.35269294 |
| 40 | MP0005164_abnormal_response_to | 1.34863528 |
| 41 | MP0010630_abnormal_cardiac_muscle | 1.32302698 |
| 42 | MP0002933_joint_inflammation | 1.32249438 |
| 43 | MP0004883_abnormal_blood_vessel | 1.32110773 |
| 44 | MP0002132_abnormal_respiratory_system | 1.31942328 |
| 45 | MP0004130_abnormal_muscle_cell | 1.28937666 |
| 46 | MP0003724_increased_susceptibility_to | 1.28201380 |
| 47 | MP0002998_abnormal_bone_remodeling | 1.27683973 |
| 48 | MP0002009_preneoplasia | 1.26261265 |
| 49 | MP0000566_synostosis | 1.22934717 |
| 50 | MP0004185_abnormal_adipocyte_glucose | 1.18926300 |
| 51 | MP0005171_absent_coat_pigmentation | 1.18219731 |
| 52 | MP0000579_abnormal_nail_morphology | 1.16352955 |
| 53 | MP0005595_abnormal_vascular_smooth | 1.15801641 |
| 54 | MP0005023_abnormal_wound_healing | 1.15069060 |
| 55 | MP0003950_abnormal_plasma_membrane | 1.14698267 |
| 56 | MP0001790_abnormal_immune_system | 1.14213190 |
| 57 | MP0005387_immune_system_phenotype | 1.14213190 |
| 58 | MP0010352_gastrointestinal_tract_polyps | 1.14142937 |
| 59 | MP0000751_myopathy | 1.13415674 |
| 60 | MP0002127_abnormal_cardiovascular_syste | 1.10410384 |
| 61 | MP0003303_peritoneal_inflammation | 1.10296285 |
| 62 | MP0003091_abnormal_cell_migration | 1.06897968 |
| 63 | MP0004484_altered_response_of | 1.06763610 |
| 64 | MP0005390_skeleton_phenotype | 1.06487525 |
| 65 | MP0002925_abnormal_cardiovascular_devel | 1.06189186 |
| 66 | MP0002168_other_aberrant_phenotype | 1.06023052 |
| 67 | MP0005397_hematopoietic_system_phenotyp | 1.06021274 |
| 68 | MP0001545_abnormal_hematopoietic_system | 1.06021274 |
| 69 | MP0003436_decreased_susceptibility_to | 1.05452820 |
| 70 | MP0000249_abnormal_blood_vessel | 1.05374183 |
| 71 | MP0005464_abnormal_platelet_physiology | 1.03928117 |
| 72 | MP0001853_heart_inflammation | 1.03796980 |
| 73 | MP0009384_cardiac_valve_regurgitation | 1.03735896 |
| 74 | MP0000428_abnormal_craniofacial_morphol | 1.02635320 |
| 75 | MP0004134_abnormal_chest_morphology | 1.02011758 |
| 76 | MP0000383_abnormal_hair_follicle | 1.01639207 |
| 77 | MP0004084_abnormal_cardiac_muscle | 1.01514784 |
| 78 | MP0003935_abnormal_craniofacial_develop | 1.00874678 |
| 79 | MP0004087_abnormal_muscle_fiber | 1.00852649 |
| 80 | MP0005174_abnormal_tail_pigmentation | 1.00434259 |
| 81 | MP0006054_spinal_hemorrhage | 1.00382034 |
| 82 | MP0001533_abnormal_skeleton_physiology | 0.97540448 |
| 83 | MP0005620_abnormal_muscle_contractility | 0.97439114 |
| 84 | MP0005330_cardiomyopathy | 0.96840481 |
| 85 | MP0005385_cardiovascular_system_phenoty | 0.95962710 |
| 86 | MP0001544_abnormal_cardiovascular_syste | 0.95962710 |
| 87 | MP0009250_abnormal_appendicular_skeleto | 0.95174728 |
| 88 | MP0005666_abnormal_adipose_tissue | 0.95053011 |
| 89 | MP0005367_renal/urinary_system_phenotyp | 0.94641138 |
| 90 | MP0000516_abnormal_urinary_system | 0.94641138 |
| 91 | MP0000003_abnormal_adipose_tissue | 0.93493854 |
| 92 | MP0005375_adipose_tissue_phenotype | 0.93228710 |
| 93 | MP0002128_abnormal_blood_circulation | 0.92442186 |
| 94 | MP0002796_impaired_skin_barrier | 0.92298164 |
| 95 | MP0001835_abnormal_antigen_presentation | 0.91860625 |
| 96 | MP0002971_abnormal_brown_adipose | 0.90250703 |
| 97 | MP0000266_abnormal_heart_morphology | 0.90099386 |
| 98 | MP0001800_abnormal_humoral_immune | 0.90045381 |
| 99 | MP0002896_abnormal_bone_mineralization | 0.89805954 |
| 100 | MP0005388_respiratory_system_phenotype | 0.89591050 |
| 101 | MP0002133_abnormal_respiratory_system | 0.89591050 |
| 102 | MP0009115_abnormal_fat_cell | 0.88882524 |
| 103 | MP0005369_muscle_phenotype | 0.87911833 |
| 104 | MP0002419_abnormal_innate_immunity | 0.87888076 |
| 105 | MP0000432_abnormal_head_morphology | 0.86926122 |
| 106 | MP0003567_abnormal_fetal_cardiomyocyte | 0.86499809 |
| 107 | MP0002106_abnormal_muscle_physiology | 0.86021810 |
| 108 | MP0001849_ear_inflammation | 0.84861276 |
| 109 | MP0002452_abnormal_antigen_presenting | 0.84131747 |
| 110 | MP0004264_abnormal_extraembryonic_tissu | 0.83785276 |
| 111 | MP0002115_abnormal_skeleton_extremities | 0.83300758 |
| 112 | MP0005410_abnormal_fertilization | 0.82475886 |
| 113 | MP0000685_abnormal_immune_system | 0.81469276 |
| 114 | MP0002938_white_spotting | 0.81350871 |
| 115 | MP0001614_abnormal_blood_vessel | 0.81021323 |
| 116 | MP0003656_abnormal_erythrocyte_physiolo | 0.81007609 |
| 117 | MP0003453_abnormal_keratinocyte_physiol | 0.80965702 |
| 118 | MP0002109_abnormal_limb_morphology | 0.79746725 |
| 119 | MP0003172_abnormal_lysosome_physiology | 0.78806004 |
| 120 | MP0008775_abnormal_heart_ventricle | 0.78765565 |
| 121 | MP0004947_skin_inflammation | 0.78599103 |
| 122 | MP0000747_muscle_weakness | 0.78036079 |
| 123 | MP0000759_abnormal_skeletal_muscle | 0.78019132 |
| 124 | MP0004782_abnormal_surfactant_physiolog | 0.77921530 |
| 125 | MP0008961_abnormal_basal_metabolism | 0.77792744 |
| 126 | MP0000163_abnormal_cartilage_morphology | 0.77693913 |
| 127 | MP0000343_altered_response_to | 0.77477631 |
| 128 | MP0001784_abnormal_fluid_regulation | 0.76905014 |
| 129 | MP0000750_abnormal_muscle_regeneration | 0.76863776 |
| 130 | MP0001243_abnormal_dermal_layer | 0.76743116 |
| 131 | MP0001299_abnormal_eye_distance/ | 0.76653219 |
| 132 | MP0002928_abnormal_bile_duct | 0.76427234 |
| 133 | MP0002249_abnormal_larynx_morphology | 0.76224250 |
| 134 | MP0001915_intracranial_hemorrhage | 0.76093058 |
| 135 | MP0000371_diluted_coat_color | 0.75572634 |
| 136 | MP0003448_altered_tumor_morphology | 0.75386789 |
| 137 | MP0000534_abnormal_ureter_morphology | 0.73478561 |
| 138 | MP0004381_abnormal_hair_follicle | 0.71888668 |
| 139 | MP0000465_gastrointestinal_hemorrhage | 0.71086418 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Broad metatarsal (HP:0001783) | 3.71254849 |
| 2 | Obstructive sleep apnea (HP:0002870) | 3.46968399 |
| 3 | Abnormality of the fingertips (HP:0001211) | 3.34895942 |
| 4 | Abnormality of the nasal septum (HP:0000419) | 3.30496916 |
| 5 | Protrusio acetabuli (HP:0003179) | 3.28245102 |
| 6 | Increased variability in muscle fiber diameter (HP:0003557) | 3.10240211 |
| 7 | Shallow orbits (HP:0000586) | 3.10147618 |
| 8 | Aortic aneurysm (HP:0004942) | 3.02911544 |
| 9 | Cerebral aneurysm (HP:0004944) | 2.97632942 |
| 10 | Asymmetric septal hypertrophy (HP:0001670) | 2.92685164 |
| 11 | Narrow palate (HP:0000189) | 2.90859095 |
| 12 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.89351635 |
| 13 | Long eyelashes (HP:0000527) | 2.84774481 |
| 14 | Prolonged bleeding time (HP:0003010) | 2.75064054 |
| 15 | Broad face (HP:0000283) | 2.71622213 |
| 16 | Exercise-induced myalgia (HP:0003738) | 2.71116675 |
| 17 | Aortic dissection (HP:0002647) | 2.66732073 |
| 18 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.65646818 |
| 19 | Short 4th metacarpal (HP:0010044) | 2.65646818 |
| 20 | Right ventricular cardiomyopathy (HP:0011663) | 2.63097409 |
| 21 | Muscle fiber splitting (HP:0003555) | 2.58709169 |
| 22 | Overgrowth (HP:0001548) | 2.52496437 |
| 23 | Premature rupture of membranes (HP:0001788) | 2.51731495 |
| 24 | Ankle contracture (HP:0006466) | 2.50873870 |
| 25 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.49909564 |
| 26 | Osteolytic defects of the hand bones (HP:0009699) | 2.49909564 |
| 27 | Spontaneous hematomas (HP:0007420) | 2.49871300 |
| 28 | Hypoplasia of the iris (HP:0007676) | 2.46791561 |
| 29 | Increased IgE level (HP:0003212) | 2.44485594 |
| 30 | Hypoplastic ischia (HP:0003175) | 2.42132488 |
| 31 | Spondylolisthesis (HP:0003302) | 2.40680625 |
| 32 | Urethral obstruction (HP:0000796) | 2.40120976 |
| 33 | Atrophic scars (HP:0001075) | 2.39902332 |
| 34 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.38695275 |
| 35 | Type 1 muscle fiber predominance (HP:0003803) | 2.38464030 |
| 36 | Increased number of teeth (HP:0011069) | 2.37124827 |
| 37 | Rectal prolapse (HP:0002035) | 2.36917302 |
| 38 | Mesomelia (HP:0003027) | 2.35315954 |
| 39 | Lip pit (HP:0100267) | 2.33579426 |
| 40 | Syringomyelia (HP:0003396) | 2.31392437 |
| 41 | Spinal cord lesions (HP:0100561) | 2.31392437 |
| 42 | Trigonocephaly (HP:0000243) | 2.30849100 |
| 43 | Neoplasm of the heart (HP:0100544) | 2.30371654 |
| 44 | Peritonitis (HP:0002586) | 2.29647409 |
| 45 | Abnormality of the parietal bone (HP:0002696) | 2.24846114 |
| 46 | Abnormality of the columella (HP:0009929) | 2.22015822 |
| 47 | Deep philtrum (HP:0002002) | 2.19841460 |
| 48 | Aneurysm (HP:0002617) | 2.19161582 |
| 49 | Mitral valve prolapse (HP:0001634) | 2.18455524 |
| 50 | Abnormality of the ischium (HP:0003174) | 2.17844602 |
| 51 | Follicular hyperkeratosis (HP:0007502) | 2.16902673 |
| 52 | Slender build (HP:0001533) | 2.15092126 |
| 53 | Volvulus (HP:0002580) | 2.12101796 |
| 54 | Periodontitis (HP:0000704) | 2.07675856 |
| 55 | Abnormality of the right ventricle (HP:0001707) | 2.05453932 |
| 56 | Macroorchidism (HP:0000053) | 2.04522302 |
| 57 | Hyperkalemia (HP:0002153) | 2.04490885 |
| 58 | Interstitial pulmonary disease (HP:0006530) | 2.02390657 |
| 59 | Aplasia cutis congenita (HP:0001057) | 2.00306030 |
| 60 | Increased connective tissue (HP:0009025) | 1.99594509 |
| 61 | Premature skin wrinkling (HP:0100678) | 1.98776324 |
| 62 | Disproportionate tall stature (HP:0001519) | 1.95885412 |
| 63 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.95356372 |
| 64 | Abnormality of the 4th metacarpal (HP:0010012) | 1.95283531 |
| 65 | Round ear (HP:0100830) | 1.94926977 |
| 66 | Pulmonary artery stenosis (HP:0004415) | 1.93798699 |
| 67 | Menorrhagia (HP:0000132) | 1.92725040 |
| 68 | Absent frontal sinuses (HP:0002688) | 1.89426590 |
| 69 | Difficulty running (HP:0009046) | 1.89402570 |
| 70 | Polycythemia (HP:0001901) | 1.88635166 |
| 71 | Popliteal pterygium (HP:0009756) | 1.88309094 |
| 72 | Easy fatigability (HP:0003388) | 1.87723533 |
| 73 | Hyporeflexia of lower limbs (HP:0002600) | 1.83937358 |
| 74 | Wormian bones (HP:0002645) | 1.83505954 |
| 75 | Epistaxis (HP:0000421) | 1.83429315 |
| 76 | Distal arthrogryposis (HP:0005684) | 1.82265439 |
| 77 | Bell-shaped thorax (HP:0001591) | 1.82099514 |
| 78 | Limited elbow extension (HP:0001377) | 1.81382027 |
| 79 | Abnormality of incisor morphology (HP:0011063) | 1.80819920 |
| 80 | Acute myeloid leukemia (HP:0004808) | 1.80740772 |
| 81 | Midline defect of the nose (HP:0004122) | 1.80558758 |
| 82 | Striae distensae (HP:0001065) | 1.80467783 |
| 83 | Broad palm (HP:0001169) | 1.80277400 |
| 84 | Anteriorly placed anus (HP:0001545) | 1.80058186 |
| 85 | Arterial tortuosity (HP:0005116) | 1.79241259 |
| 86 | Blue sclerae (HP:0000592) | 1.78753674 |
| 87 | Cervical subluxation (HP:0003308) | 1.78701647 |
| 88 | White forelock (HP:0002211) | 1.78406515 |
| 89 | Ulnar bowing (HP:0003031) | 1.78094080 |
| 90 | Subaortic stenosis (HP:0001682) | 1.78047487 |
| 91 | Abnormality of the left ventricular outflow tract (HP:0011103) | 1.78047487 |
| 92 | Papilledema (HP:0001085) | 1.77870498 |
| 93 | Depressed nasal tip (HP:0000437) | 1.77666387 |
| 94 | Hematochezia (HP:0002573) | 1.75626653 |
| 95 | Broad thumb (HP:0011304) | 1.75394391 |
| 96 | Milia (HP:0001056) | 1.74560962 |
| 97 | Dilatation of the ascending aorta (HP:0005111) | 1.73764822 |
| 98 | Ectopia lentis (HP:0001083) | 1.73372479 |
| 99 | Ulnar deviation of the wrist (HP:0003049) | 1.72930519 |
| 100 | Venous insufficiency (HP:0005293) | 1.72841964 |
| 101 | Venous abnormality (HP:0002624) | 1.72233675 |
| 102 | Laryngomalacia (HP:0001601) | 1.71957777 |
| 103 | Broad hallux (HP:0010055) | 1.71503839 |
| 104 | Fragile skin (HP:0001030) | 1.71120582 |
| 105 | Myocardial infarction (HP:0001658) | 1.69832810 |
| 106 | Thick nail (HP:0001805) | 1.68982539 |
| 107 | Genetic anticipation (HP:0003743) | 1.68470530 |
| 108 | Bruising susceptibility (HP:0000978) | 1.67776247 |
| 109 | Bladder diverticulum (HP:0000015) | 1.67559714 |
| 110 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.67489808 |
| 111 | Supernumerary ribs (HP:0005815) | 1.66597305 |
| 112 | Elbow flexion contracture (HP:0002987) | 1.66369165 |
| 113 | Vascular tortuosity (HP:0004948) | 1.66040933 |
| 114 | Malignant hyperthermia (HP:0002047) | 1.65904842 |
| 115 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.65769265 |
| 116 | Joint laxity (HP:0001388) | 1.65752336 |
| 117 | Neonatal short-limb short stature (HP:0008921) | 1.65635099 |
| 118 | Limited hip movement (HP:0008800) | 1.65323496 |
| 119 | Broad toe (HP:0001837) | 1.65300127 |
| 120 | Exostoses (HP:0100777) | 1.64974719 |
| 121 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.64702079 |
| 122 | Gingival bleeding (HP:0000225) | 1.64211043 |
| 123 | Stroke (HP:0001297) | 1.63525123 |
| 124 | Esophageal varix (HP:0002040) | 1.62735654 |
| 125 | Emphysema (HP:0002097) | 1.62536624 |
| 126 | Hypoplastic labia majora (HP:0000059) | 1.61494506 |
| 127 | Mitral regurgitation (HP:0001653) | 1.61367890 |
| 128 | Spinal rigidity (HP:0003306) | 1.60832943 |
| 129 | Ureteral obstruction (HP:0006000) | 1.60430956 |
| 130 | Flared iliac wings (HP:0002869) | 1.60242221 |
| 131 | Eczematoid dermatitis (HP:0000976) | 1.60152532 |
| 132 | Dislocated radial head (HP:0003083) | 1.59981144 |
| 133 | Oligodontia (HP:0000677) | 1.59858353 |
| 134 | Muscle fiber inclusion bodies (HP:0100299) | 1.59208897 |
| 135 | Asymmetry of the thorax (HP:0001555) | 1.58900869 |
| 136 | Genu recurvatum (HP:0002816) | 1.58010792 |
| 137 | Distal lower limb muscle weakness (HP:0009053) | 1.57647476 |
| 138 | Wide anterior fontanel (HP:0000260) | 1.57646348 |
| 139 | Mitral stenosis (HP:0001718) | 1.57195362 |
| 140 | Hypoplasia of the maxilla (HP:0000327) | 1.55891348 |
| 141 | Dysostosis multiplex (HP:0000943) | 1.55442027 |
| 142 | Thin ribs (HP:0000883) | 1.54833816 |
| 143 | Sudden death (HP:0001699) | 1.54534853 |
| 144 | Soft skin (HP:0000977) | 1.54494218 |
| 145 | Congenital stationary night blindness (HP:0007642) | 1.53645648 |
| 146 | Thin bony cortex (HP:0002753) | 1.53628223 |
| 147 | Cellulitis (HP:0100658) | 1.53402816 |
| 148 | Broad long bones (HP:0005622) | 1.52463496 |
| 149 | Thoracolumbar scoliosis (HP:0002944) | 1.52077876 |
| 150 | Ureteral stenosis (HP:0000071) | 1.51660435 |
| 151 | Thick eyebrow (HP:0000574) | 1.51516167 |
| 152 | Nemaline bodies (HP:0003798) | 1.51298419 |
| 153 | Turricephaly (HP:0000262) | 1.50701974 |
| 154 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.50615544 |
| 155 | Craniofacial hyperostosis (HP:0004493) | 1.50213652 |
| 156 | Hemorrhage of the eye (HP:0011885) | 1.50004379 |
| 157 | Bulbar palsy (HP:0001283) | 1.49937218 |
| 158 | Pigmentary retinal degeneration (HP:0001146) | 1.49294084 |
| 159 | Joint stiffness (HP:0001387) | 1.49177549 |
| 160 | Advanced eruption of teeth (HP:0006288) | 1.45976678 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SIK1 | 3.15715788 |
| 2 | CDK12 | 3.08489001 |
| 3 | LATS1 | 2.85573624 |
| 4 | ICK | 2.65887353 |
| 5 | CAMK1D | 2.57376904 |
| 6 | MYLK | 2.39458646 |
| 7 | BRD4 | 2.27117578 |
| 8 | CAMK1G | 2.19797052 |
| 9 | FGFR3 | 2.01094857 |
| 10 | TGFBR2 | 2.00171682 |
| 11 | DMPK | 1.94048913 |
| 12 | ERN1 | 1.93326704 |
| 13 | DDR2 | 1.87372198 |
| 14 | RIPK1 | 1.86714790 |
| 15 | EPHB1 | 1.74281586 |
| 16 | TTN | 1.73853049 |
| 17 | EPHA3 | 1.73133316 |
| 18 | MAP3K13 | 1.69851371 |
| 19 | STK38 | 1.65322977 |
| 20 | AKT3 | 1.62524463 |
| 21 | JAK1 | 1.54431822 |
| 22 | RIPK4 | 1.46794791 |
| 23 | MAP4K1 | 1.43358735 |
| 24 | STK3 | 1.40921030 |
| 25 | TRPM7 | 1.39726517 |
| 26 | STK38L | 1.39335674 |
| 27 | TAOK1 | 1.38996108 |
| 28 | LATS2 | 1.38070998 |
| 29 | MAP2K3 | 1.36746287 |
| 30 | TRIB3 | 1.36657054 |
| 31 | TAOK2 | 1.36608146 |
| 32 | PRKD3 | 1.32707859 |
| 33 | FGFR2 | 1.30954809 |
| 34 | KSR2 | 1.27907310 |
| 35 | PDGFRA | 1.24483128 |
| 36 | MAP3K7 | 1.22981652 |
| 37 | MELK | 1.22682618 |
| 38 | MAP3K10 | 1.21243071 |
| 39 | PRKD2 | 1.19870210 |
| 40 | PDGFRB | 1.18673459 |
| 41 | MAP3K1 | 1.17646862 |
| 42 | CHUK | 1.16831188 |
| 43 | MAPKAPK3 | 1.16696591 |
| 44 | PTK2B | 1.15906225 |
| 45 | MAP3K2 | 1.15294780 |
| 46 | PTK6 | 1.14695416 |
| 47 | MTOR | 1.14054657 |
| 48 | CDK6 | 1.09136770 |
| 49 | MARK3 | 1.05660825 |
| 50 | INSRR | 1.05596201 |
| 51 | SGK223 | 1.04858158 |
| 52 | SGK494 | 1.04858158 |
| 53 | NUAK1 | 1.04313529 |
| 54 | CDC42BPA | 1.03385589 |
| 55 | PRKAA2 | 1.03381976 |
| 56 | CSK | 1.03231609 |
| 57 | MARK2 | 1.01025166 |
| 58 | JAK3 | 1.00189590 |
| 59 | IRAK4 | 1.00148301 |
| 60 | PIK3CA | 0.99704704 |
| 61 | PIK3CG | 0.97741687 |
| 62 | TAOK3 | 0.97147963 |
| 63 | TIE1 | 0.97085629 |
| 64 | FER | 0.95205344 |
| 65 | WNK1 | 0.94676814 |
| 66 | MAPK12 | 0.93989236 |
| 67 | RET | 0.93613980 |
| 68 | SIK3 | 0.93598793 |
| 69 | CSF1R | 0.92885880 |
| 70 | MOS | 0.92280903 |
| 71 | TEC | 0.91938957 |
| 72 | PINK1 | 0.91745078 |
| 73 | BMX | 0.91728892 |
| 74 | FGFR1 | 0.90929233 |
| 75 | BTK | 0.89877664 |
| 76 | SGK3 | 0.89850552 |
| 77 | MAP3K14 | 0.89556723 |
| 78 | KIT | 0.89437882 |
| 79 | TNK2 | 0.89430230 |
| 80 | TYK2 | 0.87260401 |
| 81 | TXK | 0.85086700 |
| 82 | HCK | 0.85043756 |
| 83 | ZAK | 0.84414323 |
| 84 | FGFR4 | 0.83928371 |
| 85 | ITK | 0.82623146 |
| 86 | NEK9 | 0.80174369 |
| 87 | CDK9 | 0.78450258 |
| 88 | MAPK7 | 0.78010115 |
| 89 | FRK | 0.76642019 |
| 90 | PDPK1 | 0.75111014 |
| 91 | MAP3K3 | 0.74939203 |
| 92 | IRAK3 | 0.73136609 |
| 93 | MAP3K6 | 0.71883148 |
| 94 | CDK3 | 0.68815551 |
| 95 | CAMK4 | 0.67979853 |
| 96 | IKBKB | 0.67785921 |
| 97 | PRKD1 | 0.67731936 |
| 98 | STK10 | 0.67409897 |
| 99 | EPHB2 | 0.67313241 |
| 100 | RPS6KA6 | 0.65095770 |
| 101 | PIM2 | 0.63707369 |
| 102 | RPS6KA2 | 0.63694760 |
| 103 | MATK | 0.63367738 |
| 104 | NLK | 0.62935374 |
| 105 | YES1 | 0.60557044 |
| 106 | MAPK11 | 0.59595356 |
| 107 | RPS6KA4 | 0.59364905 |
| 108 | PIM1 | 0.59143021 |
| 109 | EEF2K | 0.58920310 |
| 110 | PRPF4B | 0.58548603 |
| 111 | PKN2 | 0.58482755 |
| 112 | ROCK1 | 0.58427159 |
| 113 | HIPK2 | 0.57399618 |
| 114 | PTK2 | 0.56630043 |
| 115 | RPS6KL1 | 0.56474403 |
| 116 | RPS6KC1 | 0.56474403 |
| 117 | LRRK2 | 0.55122188 |
| 118 | PRKAA1 | 0.54514775 |
| 119 | MAPK15 | 0.54272397 |
| 120 | STK4 | 0.50963140 |
| 121 | IRAK1 | 0.50958744 |
| 122 | SGK2 | 0.49300775 |
| 123 | MAPK1 | 0.48803834 |
| 124 | MET | 0.48737550 |
| 125 | PDK1 | 0.48603986 |
| 126 | SIK2 | 0.47964761 |
| 127 | MAPKAPK2 | 0.47794257 |
| 128 | IKBKE | 0.46103198 |
| 129 | JAK2 | 0.45842857 |
| 130 | PAK2 | 0.45646076 |
| 131 | MAPK3 | 0.45095974 |
| 132 | OBSCN | 0.44968326 |
| 133 | ZAP70 | 0.43832746 |
| 134 | BLK | 0.43453110 |
| 135 | LCK | 0.42681598 |
| 136 | ABL1 | 0.42640604 |
| 137 | MAP2K1 | 0.40947129 |
| 138 | LMTK2 | 0.39013177 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.06465578 |
| 2 | Lysine degradation_Homo sapiens_hsa00310 | 2.04319623 |
| 3 | Adherens junction_Homo sapiens_hsa04520 | 1.90992985 |
| 4 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.69781166 |
| 5 | Viral myocarditis_Homo sapiens_hsa05416 | 1.68999841 |
| 6 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.64176912 |
| 7 | Focal adhesion_Homo sapiens_hsa04510 | 1.62167734 |
| 8 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.61450775 |
| 9 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.58863028 |
| 10 | Leishmaniasis_Homo sapiens_hsa05140 | 1.57915886 |
| 11 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.56062205 |
| 12 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.51187427 |
| 13 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.49490890 |
| 14 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.46887929 |
| 15 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.46012659 |
| 16 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.43727336 |
| 17 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.43058619 |
| 18 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.42606741 |
| 19 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.42016028 |
| 20 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.41801943 |
| 21 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.41735437 |
| 22 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.41179801 |
| 23 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.39961164 |
| 24 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.34529805 |
| 25 | Measles_Homo sapiens_hsa05162 | 1.33084117 |
| 26 | Malaria_Homo sapiens_hsa05144 | 1.31753591 |
| 27 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.29805983 |
| 28 | Insulin resistance_Homo sapiens_hsa04931 | 1.27117432 |
| 29 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.26905191 |
| 30 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.21589758 |
| 31 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.21390656 |
| 32 | Prostate cancer_Homo sapiens_hsa05215 | 1.19703426 |
| 33 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.15175271 |
| 34 | Amoebiasis_Homo sapiens_hsa05146 | 1.12675635 |
| 35 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.12403542 |
| 36 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.12178658 |
| 37 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.11419292 |
| 38 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.10062162 |
| 39 | Glioma_Homo sapiens_hsa05214 | 1.09598233 |
| 40 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.09348085 |
| 41 | Hepatitis B_Homo sapiens_hsa05161 | 1.09208771 |
| 42 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.06884667 |
| 43 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.06110376 |
| 44 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.05985965 |
| 45 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.05735008 |
| 46 | Renin secretion_Homo sapiens_hsa04924 | 1.05610536 |
| 47 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.05088406 |
| 48 | Platelet activation_Homo sapiens_hsa04611 | 1.05051903 |
| 49 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.04067530 |
| 50 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.03719153 |
| 51 | Thyroid cancer_Homo sapiens_hsa05216 | 1.02897462 |
| 52 | Colorectal cancer_Homo sapiens_hsa05210 | 1.02700294 |
| 53 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.01965354 |
| 54 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.01276521 |
| 55 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.00823474 |
| 56 | Pathways in cancer_Homo sapiens_hsa05200 | 0.98264779 |
| 57 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.97944196 |
| 58 | Influenza A_Homo sapiens_hsa05164 | 0.96583921 |
| 59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.96475986 |
| 60 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.95578081 |
| 61 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.95346272 |
| 62 | Other glycan degradation_Homo sapiens_hsa00511 | 0.93735384 |
| 63 | Endometrial cancer_Homo sapiens_hsa05213 | 0.92334656 |
| 64 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.92180566 |
| 65 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.92025397 |
| 66 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.90223195 |
| 67 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.90132938 |
| 68 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.89525450 |
| 69 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.89477826 |
| 70 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.88468630 |
| 71 | Gap junction_Homo sapiens_hsa04540 | 0.87715286 |
| 72 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.87713227 |
| 73 | Tuberculosis_Homo sapiens_hsa05152 | 0.86697900 |
| 74 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.86215749 |
| 75 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.86029338 |
| 76 | Circadian rhythm_Homo sapiens_hsa04710 | 0.85683662 |
| 77 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.84480631 |
| 78 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.84404453 |
| 79 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.84064922 |
| 80 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.84046968 |
| 81 | Melanoma_Homo sapiens_hsa05218 | 0.83334521 |
| 82 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.83270498 |
| 83 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.82944085 |
| 84 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.82667469 |
| 85 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.82174691 |
| 86 | HTLV-I infection_Homo sapiens_hsa05166 | 0.81552171 |
| 87 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.80369819 |
| 88 | Salivary secretion_Homo sapiens_hsa04970 | 0.79929770 |
| 89 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.77742836 |
| 90 | Long-term potentiation_Homo sapiens_hsa04720 | 0.77457770 |
| 91 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.76727165 |
| 92 | Apoptosis_Homo sapiens_hsa04210 | 0.76695872 |
| 93 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.76596957 |
| 94 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.75220396 |
| 95 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.74848706 |
| 96 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.74826341 |
| 97 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.74687518 |
| 98 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.74086638 |
| 99 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.74027760 |
| 100 | Shigellosis_Homo sapiens_hsa05131 | 0.73563746 |
| 101 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.72932054 |
| 102 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.72370619 |
| 103 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.72182551 |
| 104 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.71888085 |
| 105 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.70203470 |
| 106 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.67175288 |
| 107 | Hepatitis C_Homo sapiens_hsa05160 | 0.67132032 |
| 108 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.66586045 |
| 109 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.64551513 |
| 110 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.64477914 |
| 111 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.63813360 |
| 112 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.63393118 |
| 113 | Endocytosis_Homo sapiens_hsa04144 | 0.63331064 |
| 114 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.63208432 |
| 115 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.62715317 |
| 116 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.62028571 |
| 117 | ABC transporters_Homo sapiens_hsa02010 | 0.61643622 |
| 118 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.61274755 |
| 119 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.60987987 |
| 120 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.60391033 |
| 121 | Salmonella infection_Homo sapiens_hsa05132 | 0.60057652 |
| 122 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.60044011 |
| 123 | Pertussis_Homo sapiens_hsa05133 | 0.59980206 |
| 124 | Bladder cancer_Homo sapiens_hsa05219 | 0.59942980 |
| 125 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.59796745 |
| 126 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.59475747 |
| 127 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.59393087 |
| 128 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.59056374 |
| 129 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.58341441 |
| 130 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.57133749 |

