ATF7IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.37436261
2neural tube formation (GO:0001841)5.00471917
3axon ensheathment in central nervous system (GO:0032291)4.33657648
4central nervous system myelination (GO:0022010)4.33657648
5nucleobase catabolic process (GO:0046113)3.92102875
6pre-miRNA processing (GO:0031054)3.90701333
7limb bud formation (GO:0060174)3.83168610
8interkinetic nuclear migration (GO:0022027)3.79398701
9negative regulation of execution phase of apoptosis (GO:1900118)3.60457307
10regulation of somitogenesis (GO:0014807)3.52734706
11establishment of protein localization to Golgi (GO:0072600)3.45668663
12presynaptic membrane assembly (GO:0097105)3.41903304
13retina layer formation (GO:0010842)3.29957876
14establishment of nucleus localization (GO:0040023)3.29109473
15histone H3-K4 trimethylation (GO:0080182)3.28589070
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.28580053
17positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.23616579
18mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.23616579
19olfactory bulb development (GO:0021772)3.19732432
20activated T cell proliferation (GO:0050798)3.18153385
21histone H2A acetylation (GO:0043968)3.17818762
22microtubule anchoring (GO:0034453)3.17245212
23negative regulation of DNA recombination (GO:0045910)3.14182369
24cytoplasmic mRNA processing body assembly (GO:0033962)3.13268787
25central nervous system neuron axonogenesis (GO:0021955)3.09987209
26protein targeting to Golgi (GO:0000042)3.09829924
27nucleus localization (GO:0051647)3.04950517
28positive regulation of protein kinase C signaling (GO:0090037)3.03614723
29presynaptic membrane organization (GO:0097090)3.01658635
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00106755
31retinal ganglion cell axon guidance (GO:0031290)2.99480340
32cranial nerve morphogenesis (GO:0021602)2.95875021
33eye photoreceptor cell differentiation (GO:0001754)2.95020036
34photoreceptor cell differentiation (GO:0046530)2.95020036
35DNA integration (GO:0015074)2.91718696
36lymphoid progenitor cell differentiation (GO:0002320)2.90643030
37eyelid development in camera-type eye (GO:0061029)2.90238554
38axonal fasciculation (GO:0007413)2.87251812
39neuronal stem cell maintenance (GO:0097150)2.87174923
40retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87107457
41monoubiquitinated protein deubiquitination (GO:0035520)2.85806592
42pyrimidine dimer repair (GO:0006290)2.83097616
43centriole replication (GO:0007099)2.82725222
44regulation of telomere maintenance (GO:0032204)2.80850528
45neurotransmitter-gated ion channel clustering (GO:0072578)2.79926611
46definitive hemopoiesis (GO:0060216)2.79379002
47mesenchymal cell differentiation involved in renal system development (GO:2001012)2.75330679
48mesenchymal cell differentiation involved in kidney development (GO:0072161)2.75330679
49DNA double-strand break processing (GO:0000729)2.71282479
50calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.71135212
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70664574
52negative regulation of translation, ncRNA-mediated (GO:0040033)2.70664574
53regulation of translation, ncRNA-mediated (GO:0045974)2.70664574
54postsynaptic membrane organization (GO:0001941)2.70021177
55mechanosensory behavior (GO:0007638)2.69830670
56lateral sprouting from an epithelium (GO:0060601)2.69829990
57short-term memory (GO:0007614)2.69569267
58establishment of mitochondrion localization (GO:0051654)2.69290641
59mRNA splice site selection (GO:0006376)2.68582076
60histone mRNA catabolic process (GO:0071044)2.68374353
61microtubule nucleation (GO:0007020)2.67749423
62nonmotile primary cilium assembly (GO:0035058)2.65555465
63regulation of pigment cell differentiation (GO:0050932)2.65269406
64negative regulation of oligodendrocyte differentiation (GO:0048715)2.65140764
65forebrain neuron differentiation (GO:0021879)2.64584998
66synapse assembly (GO:0007416)2.63516914
67head development (GO:0060322)2.62550371
68histone H3-K36 demethylation (GO:0070544)2.61256884
69intraciliary transport (GO:0042073)2.60870626
70negative regulation of myoblast differentiation (GO:0045662)2.60185923
71ncRNA catabolic process (GO:0034661)2.57238018
72somite development (GO:0061053)2.56715987
73dosage compensation (GO:0007549)2.55994041
74positive regulation of developmental pigmentation (GO:0048087)2.55519627
75cell proliferation in forebrain (GO:0021846)2.53683570
76vocalization behavior (GO:0071625)2.52868650
77auditory behavior (GO:0031223)2.51755195
78cerebral cortex radially oriented cell migration (GO:0021799)2.50255130
79histone H3-K4 methylation (GO:0051568)2.48710271
80regulation of growth hormone secretion (GO:0060123)2.48193346
81regulation of timing of cell differentiation (GO:0048505)2.46943214
82regulation of histone H3-K9 methylation (GO:0051570)2.46775691
83protein K11-linked deubiquitination (GO:0035871)2.46190823
84neuron recognition (GO:0008038)2.46178279
85cerebellar Purkinje cell differentiation (GO:0021702)2.45886742
86cerebral cortex cell migration (GO:0021795)2.45711651
87histone lysine methylation (GO:0034968)2.44836717
88facial nerve structural organization (GO:0021612)2.43716324
89positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.43008563
90organ growth (GO:0035265)2.42955406
91spinal cord motor neuron differentiation (GO:0021522)2.42901922
92peptidyl-lysine methylation (GO:0018022)2.42762658
93positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.42263544
94peptidyl-lysine trimethylation (GO:0018023)2.41477841
95appendage development (GO:0048736)2.40970671
96limb development (GO:0060173)2.40970671
97centriole assembly (GO:0098534)2.40895561
98cranial nerve structural organization (GO:0021604)2.40615952
99GMP metabolic process (GO:0046037)2.40413219
100regulation of gene silencing by RNA (GO:0060966)2.40395549
101regulation of posttranscriptional gene silencing (GO:0060147)2.40395549
102regulation of gene silencing by miRNA (GO:0060964)2.40395549
103histone lysine demethylation (GO:0070076)2.39722047
104mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39545670
105righting reflex (GO:0060013)2.39176352
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.38813183
107DNA ligation (GO:0006266)2.38504311
108behavioral response to ethanol (GO:0048149)2.38157577
109histone H3-K9 methylation (GO:0051567)2.37995581
110positive regulation of granulocyte differentiation (GO:0030854)2.37012505
111hippocampus development (GO:0021766)2.36787986
112behavioral response to nicotine (GO:0035095)2.36785312
113cell differentiation in spinal cord (GO:0021515)2.35985785
114cell differentiation involved in metanephros development (GO:0072202)2.35478653
115epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.34039509
116dentate gyrus development (GO:0021542)2.33826257
117endocardial cushion morphogenesis (GO:0003203)2.33611581
118male sex determination (GO:0030238)2.33518947
119regulation of collateral sprouting (GO:0048670)2.33151881
120radial glial cell differentiation (GO:0060019)2.32566874
121regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32529068
122nephron epithelium development (GO:0072009)2.30675913
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29507611
124regulation of oligodendrocyte differentiation (GO:0048713)2.28565889
125V(D)J recombination (GO:0033151)2.28168674
126nerve growth factor signaling pathway (GO:0038180)2.28005728
127left/right axis specification (GO:0070986)2.27284163
128regulation of development, heterochronic (GO:0040034)2.27144702
129histone H2B ubiquitination (GO:0033523)2.27071939
130negative regulation of histone methylation (GO:0031061)2.25782528
131regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.25657360
132sympathetic nervous system development (GO:0048485)2.25392170
133face development (GO:0060324)2.25257060
134epithelial tube formation (GO:0072175)2.24815638
135cell differentiation involved in kidney development (GO:0061005)2.24638256
136histone demethylation (GO:0016577)2.24387584
137regulation of telomere maintenance via telomerase (GO:0032210)2.24220564
138mesonephros development (GO:0001823)2.21822327
139cardiac ventricle formation (GO:0003211)2.21433093
140negative regulation of keratinocyte proliferation (GO:0010839)2.20539222
141interferon-gamma production (GO:0032609)2.20392190
142central nervous system projection neuron axonogenesis (GO:0021952)2.19767352
143collecting duct development (GO:0072044)2.19670707
144DNA methylation involved in gamete generation (GO:0043046)2.17224062
145heart valve formation (GO:0003188)2.16415839
146generation of neurons (GO:0048699)2.15740627
147otic vesicle formation (GO:0030916)2.15542073
148mesenchyme morphogenesis (GO:0072132)2.14985133
149kinetochore assembly (GO:0051382)2.14571886
150photoreceptor cell maintenance (GO:0045494)2.14566444
151somatic stem cell division (GO:0048103)2.14459773
152nephron tubule development (GO:0072080)2.14285782
153histone H3-K9 modification (GO:0061647)2.11219152
154metanephric nephron tubule development (GO:0072234)2.10613048
155metanephric tubule development (GO:0072170)2.10613048
156negative regulation of axon guidance (GO:1902668)2.09824970
157renal tubule development (GO:0061326)2.09074987
158positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.08319491
159regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.08319491
160microtubule depolymerization (GO:0007019)2.08164713
161negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.07082271
162kinetochore organization (GO:0051383)2.05534433
163regulation of histone H3-K27 methylation (GO:0061085)2.05230817
164regulation of non-canonical Wnt signaling pathway (GO:2000050)2.03471685
165cardiac chamber formation (GO:0003207)2.02179643
166cranial nerve development (GO:0021545)2.01972779
167mesenchymal cell differentiation (GO:0048762)2.01933212
168regulation of histone H3-K4 methylation (GO:0051569)2.01080405
169female gonad development (GO:0008585)2.00955446
170cornea development in camera-type eye (GO:0061303)2.00557398
171positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.00368051
172regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.00368051
173pattern specification involved in kidney development (GO:0061004)2.00007560
174neuron cell-cell adhesion (GO:0007158)1.99583590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89794448
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.28870875
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85221368
4GBX2_23144817_ChIP-Seq_PC3_Human2.84667958
5ZNF274_21170338_ChIP-Seq_K562_Hela2.64662627
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.58741438
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43296308
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37488557
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.30982523
10AR_21572438_ChIP-Seq_LNCaP_Human2.27385708
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.23081863
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11371667
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09159685
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08046523
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.06457275
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05231200
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.01649006
18RNF2_27304074_Chip-Seq_NSC_Mouse1.99275685
19TAF15_26573619_Chip-Seq_HEK293_Human1.98596300
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96574348
21RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90276319
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88584525
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87180259
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85700593
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85700593
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85473759
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84417227
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81674145
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77926011
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77562131
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77476789
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.74257091
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72457663
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.70879347
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.67445952
36IGF1R_20145208_ChIP-Seq_DFB_Human1.66578473
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65000890
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64769347
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61995037
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56070161
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55416219
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55198845
43SCL_19346495_ChIP-Seq_HPC-7_Human1.54278340
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.54193783
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52955898
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52734598
47CBP_20019798_ChIP-Seq_JUKART_Human1.52734598
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50753236
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50495878
50* P300_19829295_ChIP-Seq_ESCs_Human1.49559947
51FUS_26573619_Chip-Seq_HEK293_Human1.47814156
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.46614526
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46278757
54EWS_26573619_Chip-Seq_HEK293_Human1.45898008
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.45306300
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45043938
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44565468
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43626724
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40962925
60* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38641213
61* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38641213
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38191760
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.36871274
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.36400797
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.33442052
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.32731134
67ER_23166858_ChIP-Seq_MCF-7_Human1.31814990
68VDR_22108803_ChIP-Seq_LS180_Human1.31502179
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.29829429
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29340646
71BCAT_22108803_ChIP-Seq_LS180_Human1.28599809
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28231855
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27816500
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27283771
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26494592
76AR_25329375_ChIP-Seq_VCAP_Human1.25386929
77* RUNX2_22187159_ChIP-Seq_PCA_Human1.24670249
78DROSHA_22980978_ChIP-Seq_HELA_Human1.24456638
79P300_18555785_Chip-Seq_ESCs_Mouse1.24300950
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24129289
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24032038
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23572514
83AHR_22903824_ChIP-Seq_MCF-7_Human1.23076743
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22954616
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22905371
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22403566
87P53_22387025_ChIP-Seq_ESCs_Mouse1.22345276
88TP53_16413492_ChIP-PET_HCT116_Human1.22285679
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.22221519
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22106503
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21669023
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.20770408
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.20028220
94IRF1_19129219_ChIP-ChIP_H3396_Human1.19423149
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17440853
96* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17135088
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.15349661
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14899701
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14843322
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14681535
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.14488489
102SOX9_26525672_Chip-Seq_HEART_Mouse1.14348350
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14327292
104NMYC_18555785_Chip-Seq_ESCs_Mouse1.13523396
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13517964
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.12975811
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12776951
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12328240
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.12122025
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12058564
111STAT3_23295773_ChIP-Seq_U87_Human1.11583169
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.11388104
113* TCF4_23295773_ChIP-Seq_U87_Human1.11170640
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09277499
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.08832438
116ZFX_18555785_Chip-Seq_ESCs_Mouse1.08464387
117TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08291027
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08253110
119REST_21632747_ChIP-Seq_MESCs_Mouse1.08021236
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08006995
121KDM2B_26808549_Chip-Seq_REH_Human1.07492955
122CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07240648
123* TCF4_22108803_ChIP-Seq_LS180_Human1.06712244
124* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05995528
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05989078
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05395111
127RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05184823
128SOX2_18555785_Chip-Seq_ESCs_Mouse1.04719478
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04347004
130TCF4_18268006_ChIP-ChIP_LS174T_Human1.04225560
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03979874
132RUNX_20019798_ChIP-Seq_JUKART_Human1.03944625
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03934462
134SOX2_16153702_ChIP-ChIP_HESCs_Human1.03193695
135CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01997055
136KLF4_18555785_Chip-Seq_ESCs_Mouse1.01807949
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01767566
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99731895
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98325159
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98165144
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97165453
142* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97121951
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96819540
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96532983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.95920369
2MP0005409_darkened_coat_color4.55085043
3MP0001188_hyperpigmentation4.25677883
4MP0000566_synostosis4.11069286
5MP0004381_abnormal_hair_follicle3.61616245
6MP0002102_abnormal_ear_morphology3.11201969
7MP0003880_abnormal_central_pattern2.80270286
8MP0006292_abnormal_olfactory_placode2.63520287
9MP0005174_abnormal_tail_pigmentation2.48908138
10MP0001529_abnormal_vocalization2.48074063
11MP0001984_abnormal_olfaction2.32055432
12MP0003890_abnormal_embryonic-extraembry2.30886220
13MP0000015_abnormal_ear_pigmentation2.22848320
14MP0002822_catalepsy2.17645521
15MP0003122_maternal_imprinting2.07232289
16MP0005423_abnormal_somatic_nervous2.02467862
17MP0002249_abnormal_larynx_morphology1.97676889
18MP0005187_abnormal_penis_morphology1.76194033
19MP0003567_abnormal_fetal_cardiomyocyte1.72377649
20MP0003221_abnormal_cardiomyocyte_apopto1.72299572
21MP0004742_abnormal_vestibular_system1.64287737
22MP0003938_abnormal_ear_development1.61785887
23MP0003787_abnormal_imprinting1.59084164
24MP0000049_abnormal_middle_ear1.56471472
25MP0000778_abnormal_nervous_system1.52548980
26MP0004859_abnormal_synaptic_plasticity1.50604242
27MP0002095_abnormal_skin_pigmentation1.49126030
28MP0002277_abnormal_respiratory_mucosa1.46934521
29MP0005248_abnormal_Harderian_gland1.42069247
30MP0002938_white_spotting1.41659458
31MP0008995_early_reproductive_senescence1.41327248
32MP0002177_abnormal_outer_ear1.40371994
33MP0002653_abnormal_ependyma_morphology1.39536798
34MP0009250_abnormal_appendicular_skeleto1.37960312
35MP0000569_abnormal_digit_pigmentation1.37951898
36MP0003937_abnormal_limbs/digits/tail_de1.37729989
37MP0004142_abnormal_muscle_tone1.33630279
38MP0008057_abnormal_DNA_replication1.29789970
39MP0000955_abnormal_spinal_cord1.27824689
40MP0004924_abnormal_behavior1.27641553
41MP0005386_behavior/neurological_phenoty1.27641553
42MP0003635_abnormal_synaptic_transmissio1.27180899
43MP0004811_abnormal_neuron_physiology1.25971055
44MP0002396_abnormal_hematopoietic_system1.25451701
45MP0001486_abnormal_startle_reflex1.25151671
46MP0009046_muscle_twitch1.24514948
47MP0003119_abnormal_digestive_system1.24441495
48MP0002063_abnormal_learning/memory/cond1.23686663
49MP0001986_abnormal_taste_sensitivity1.23566154
50MP0000383_abnormal_hair_follicle1.23256238
51MP0002009_preneoplasia1.21337924
52MP0010030_abnormal_orbit_morphology1.20164751
53MP0000631_abnormal_neuroendocrine_gland1.19906564
54MP0008789_abnormal_olfactory_epithelium1.19275819
55MP0005551_abnormal_eye_electrophysiolog1.18322562
56MP0004270_analgesia1.18105976
57MP0001346_abnormal_lacrimal_gland1.15343374
58MP0000026_abnormal_inner_ear1.15143211
59MP0002735_abnormal_chemical_nociception1.15126849
60MP0002152_abnormal_brain_morphology1.08736380
61MP0001286_abnormal_eye_development1.07937531
62MP0006072_abnormal_retinal_apoptosis1.07435778
63MP0002572_abnormal_emotion/affect_behav1.04637380
64MP0003941_abnormal_skin_development1.03502914
65MP0005075_abnormal_melanosome_morpholog1.01221952
66MP0003315_abnormal_perineum_morphology1.00654935
67MP0002751_abnormal_autonomic_nervous1.00534542
68MP0003755_abnormal_palate_morphology0.99398876
69MP0004134_abnormal_chest_morphology0.98757247
70MP0003935_abnormal_craniofacial_develop0.98561424
71MP0009745_abnormal_behavioral_response0.97467563
72MP0004145_abnormal_muscle_electrophysio0.97029347
73MP0002638_abnormal_pupillary_reflex0.96439997
74MP0005394_taste/olfaction_phenotype0.95947910
75MP0005499_abnormal_olfactory_system0.95947910
76MP0004133_heterotaxia0.95609568
77MP0001879_abnormal_lymphatic_vessel0.94917712
78MP0002272_abnormal_nervous_system0.94427844
79MP0002736_abnormal_nociception_after0.93728076
80MP0000427_abnormal_hair_cycle0.93604583
81MP0002752_abnormal_somatic_nervous0.91277630
82MP0003385_abnormal_body_wall0.90955619
83MP0002234_abnormal_pharynx_morphology0.90544716
84MP0004197_abnormal_fetal_growth/weight/0.90191877
85MP0006276_abnormal_autonomic_nervous0.90014098
86MP0005171_absent_coat_pigmentation0.89850787
87MP0009703_decreased_birth_body0.89714385
88MP0003763_abnormal_thymus_physiology0.89479103
89MP0002233_abnormal_nose_morphology0.89389481
90MP0005257_abnormal_intraocular_pressure0.89358683
91MP0000579_abnormal_nail_morphology0.87711007
92MP0009379_abnormal_foot_pigmentation0.87450289
93MP0002116_abnormal_craniofacial_bone0.87219125
94MP0001177_atelectasis0.87132389
95MP0008877_abnormal_DNA_methylation0.85349994
96MP0000465_gastrointestinal_hemorrhage0.83216685
97MP0001963_abnormal_hearing_physiology0.81606795
98MP0000762_abnormal_tongue_morphology0.81568477
99MP0003861_abnormal_nervous_system0.80734748
100MP0002697_abnormal_eye_size0.80311943
101MP0005645_abnormal_hypothalamus_physiol0.80079745
102MP0005646_abnormal_pituitary_gland0.80070333
103MP0005253_abnormal_eye_physiology0.78607150
104MP0005195_abnormal_posterior_eye0.78586953
105MP0000467_abnormal_esophagus_morphology0.77688072
106MP0001968_abnormal_touch/_nociception0.77493123
107MP0000432_abnormal_head_morphology0.76417868
108MP0003121_genomic_imprinting0.76233221
109MP0001340_abnormal_eyelid_morphology0.76212721
110MP0005391_vision/eye_phenotype0.76075059
111MP0001485_abnormal_pinna_reflex0.73197621
112MP0003828_pulmonary_edema0.72642679
113MP0001299_abnormal_eye_distance/0.72273756
114MP0002081_perinatal_lethality0.72174961
115MP0002282_abnormal_trachea_morphology0.71844950
116MP0002163_abnormal_gland_morphology0.71692781
117MP0002734_abnormal_mechanical_nocicepti0.71570441
118MP0002557_abnormal_social/conspecific_i0.71325469
119MP0002098_abnormal_vibrissa_morphology0.70472186
120MP0008569_lethality_at_weaning0.69920562
121MP0002084_abnormal_developmental_patter0.68593829
122MP0002067_abnormal_sensory_capabilities0.68443974
123MP0000428_abnormal_craniofacial_morphol0.68220220
124MP0002882_abnormal_neuron_morphology0.67725253
125MP0001293_anophthalmia0.67630410
126MP0001502_abnormal_circadian_rhythm0.67382766
127MP0003950_abnormal_plasma_membrane0.66827745
128MP0005377_hearing/vestibular/ear_phenot0.66673720
129MP0003878_abnormal_ear_physiology0.66673720
130MP0003698_abnormal_male_reproductive0.66645884
131MP0002075_abnormal_coat/hair_pigmentati0.66259560
132MP0008058_abnormal_DNA_repair0.64910429
133MP0001943_abnormal_respiration0.64174459
134MP0002069_abnormal_eating/drinking_beha0.63688083
135MP0002184_abnormal_innervation0.63308638
136MP0000920_abnormal_myelination0.63159503
137MP0002092_abnormal_eye_morphology0.63123824
138MP0000647_abnormal_sebaceous_gland0.63009205
139MP0000613_abnormal_salivary_gland0.62957096
140MP0002909_abnormal_adrenal_gland0.62298571
141MP0002928_abnormal_bile_duct0.61810289
142MP0000703_abnormal_thymus_morphology0.61438832
143MP0004885_abnormal_endolymph0.60932733
144MP0002114_abnormal_axial_skeleton0.59677878
145MP0001186_pigmentation_phenotype0.59423100
146MP0002132_abnormal_respiratory_system0.58590430
147MP0002109_abnormal_limb_morphology0.58519611

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)3.57676420
2Papillary thyroid carcinoma (HP:0002895)3.29529710
3Colon cancer (HP:0003003)3.25677506
4Medulloblastoma (HP:0002885)3.09849055
5Alacrima (HP:0000522)3.09042884
6Abnormality of the fingertips (HP:0001211)3.03496043
7Sex reversal (HP:0012245)3.01378632
8Abnormal sex determination (HP:0012244)3.01378632
9Genetic anticipation (HP:0003743)2.99505409
10Drooling (HP:0002307)2.98830953
11Cortical dysplasia (HP:0002539)2.87005813
12Lissencephaly (HP:0001339)2.86875977
13Excessive salivation (HP:0003781)2.86492035
14Aplasia cutis congenita (HP:0001057)2.83578323
15Abnormality of the axillary hair (HP:0100134)2.82129095
16Abnormality of secondary sexual hair (HP:0009888)2.82129095
17Decreased lacrimation (HP:0000633)2.81467831
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71839884
19Chronic hepatic failure (HP:0100626)2.68185467
20Abnormality of the labia minora (HP:0012880)2.63705665
21Medial flaring of the eyebrow (HP:0010747)2.63176549
22Gait imbalance (HP:0002141)2.62934146
23Chromsome breakage (HP:0040012)2.62466771
24Attenuation of retinal blood vessels (HP:0007843)2.61149131
25Septo-optic dysplasia (HP:0100842)2.60421665
26Obstructive sleep apnea (HP:0002870)2.58014267
27Congenital primary aphakia (HP:0007707)2.56266786
28Nasolacrimal duct obstruction (HP:0000579)2.54957297
29Amyotrophic lateral sclerosis (HP:0007354)2.52031702
30Nephrogenic diabetes insipidus (HP:0009806)2.51786581
31Genital tract atresia (HP:0001827)2.51394880
32Abnormality of incisor morphology (HP:0011063)2.50703523
33Lip pit (HP:0100267)2.50280985
34Midline defect of the nose (HP:0004122)2.50134852
35Hip dysplasia (HP:0001385)2.46017480
36Vaginal atresia (HP:0000148)2.45860471
37Hyperventilation (HP:0002883)2.45325057
38Cupped ear (HP:0000378)2.42882565
39Abnormal ciliary motility (HP:0012262)2.38859072
40Stomach cancer (HP:0012126)2.36431914
41Protruding tongue (HP:0010808)2.35812951
42Absent/shortened dynein arms (HP:0200106)2.35709546
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.35709546
44Poor coordination (HP:0002370)2.34890372
45Progressive cerebellar ataxia (HP:0002073)2.33881779
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29788684
47Agammaglobulinemia (HP:0004432)2.29772201
48White forelock (HP:0002211)2.29422537
49Duplication of thumb phalanx (HP:0009942)2.28902281
50Vitreoretinal degeneration (HP:0000655)2.27952328
51Abnormality of the nasolacrimal system (HP:0000614)2.25377313
52Thyroid carcinoma (HP:0002890)2.22738115
53Abnormality of the lacrimal duct (HP:0011481)2.21600781
54Partial duplication of thumb phalanx (HP:0009944)2.19074290
55Ectopic kidney (HP:0000086)2.16791623
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.16003388
57Decreased central vision (HP:0007663)2.14603750
58Absent septum pellucidum (HP:0001331)2.12557212
59Broad foot (HP:0001769)2.11893438
60Pancreatic cysts (HP:0001737)2.11199658
61Abnormal hair whorl (HP:0010721)2.10654589
62Abnormality of the septum pellucidum (HP:0007375)2.10192376
63Pachygyria (HP:0001302)2.09437223
64Overfolded helix (HP:0000396)2.07231013
65Duplicated collecting system (HP:0000081)2.05465495
66Neoplasm of the adrenal cortex (HP:0100641)2.05123134
67Patchy hypopigmentation of hair (HP:0011365)2.04699900
68Abnormality of the renal collecting system (HP:0004742)2.04292698
69Absent speech (HP:0001344)2.03891206
70Abnormality of the musculature of the pelvis (HP:0001469)2.03408110
71Abnormality of the hip-girdle musculature (HP:0001445)2.03408110
72Retinal dysplasia (HP:0007973)2.02907051
73Atonic seizures (HP:0010819)2.02884131
74Oligodactyly (hands) (HP:0001180)2.00925409
75Neoplasm of the oral cavity (HP:0100649)2.00858877
76Glioma (HP:0009733)2.00309476
77Optic nerve hypoplasia (HP:0000609)1.99241587
78Abnormal respiratory motile cilium physiology (HP:0012261)1.99200023
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.98556162
80Short 4th metacarpal (HP:0010044)1.98556162
81Truncal obesity (HP:0001956)1.97822835
82High anterior hairline (HP:0009890)1.97749142
83Aqueductal stenosis (HP:0002410)1.96466207
84Abnormality of the nasal septum (HP:0000419)1.96282993
85Congenital stationary night blindness (HP:0007642)1.95714732
86Partial duplication of the phalanx of hand (HP:0009999)1.95593544
87Specific learning disability (HP:0001328)1.94669396
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.94006799
89Degeneration of the lateral corticospinal tracts (HP:0002314)1.94006799
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.93440345
91Germ cell neoplasia (HP:0100728)1.92326380
92Gaze-evoked nystagmus (HP:0000640)1.91755378
93Chin dimple (HP:0010751)1.91302641
94Pelvic girdle muscle weakness (HP:0003749)1.91253408
95Abnormally folded helix (HP:0008544)1.91229799
96True hermaphroditism (HP:0010459)1.90950711
97Abnormality of the columella (HP:0009929)1.90864233
98Growth hormone deficiency (HP:0000824)1.90261850
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88831230
100Abnormality of the parietal bone (HP:0002696)1.88042876
101Anal stenosis (HP:0002025)1.87767711
102Abnormality of the right ventricle (HP:0001707)1.87450596
103Laryngomalacia (HP:0001601)1.87066254
104Partial agenesis of the corpus callosum (HP:0001338)1.87028041
105Conical tooth (HP:0000698)1.86820249
106Urinary urgency (HP:0000012)1.86265677
107Abnormality of the incisor (HP:0000676)1.85296300
108Abnormality of the astrocytes (HP:0100707)1.85135965
109Astrocytoma (HP:0009592)1.85135965
110Tented upper lip vermilion (HP:0010804)1.84581782
111Progressive inability to walk (HP:0002505)1.83342856
112Micropenis (HP:0000054)1.83342153
113Polyphagia (HP:0002591)1.82810487
114Abnormality of the corticospinal tract (HP:0002492)1.80877665
115Thyroid-stimulating hormone excess (HP:0002925)1.79489926
116Short foot (HP:0001773)1.79426561
117Focal motor seizures (HP:0011153)1.78940967
118Abnormal respiratory epithelium morphology (HP:0012253)1.78211753
119Abnormal respiratory motile cilium morphology (HP:0005938)1.78211753
120Pancreatic fibrosis (HP:0100732)1.77420034
121Exotropia (HP:0000577)1.77188163
122Nephronophthisis (HP:0000090)1.77130703
123Volvulus (HP:0002580)1.76907506
124Split foot (HP:0001839)1.76162759
125Atelectasis (HP:0100750)1.74897632
126Labial hypoplasia (HP:0000066)1.74693237
127Febrile seizures (HP:0002373)1.74044650
128Thickened helices (HP:0000391)1.73826215
129Preaxial hand polydactyly (HP:0001177)1.73619825
130Hypoplasia of the brainstem (HP:0002365)1.72064619
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72064619
132Abnormality of salivation (HP:0100755)1.71620835
133Thyroiditis (HP:0100646)1.71414011
134Focal seizures (HP:0007359)1.70854549
135Anophthalmia (HP:0000528)1.70288182
136Rhabdomyosarcoma (HP:0002859)1.69933450
137Narrow forehead (HP:0000341)1.69826728
138Intestinal atresia (HP:0011100)1.68845722
139Patellar aplasia (HP:0006443)1.68596042
140Postaxial hand polydactyly (HP:0001162)1.68483841
141Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67856202
142Abnormality of the renal medulla (HP:0100957)1.67675179
143Abnormality of the pubic bones (HP:0003172)1.67486705
144Inability to walk (HP:0002540)1.67195620
145Impaired vibration sensation in the lower limbs (HP:0002166)1.66884608
146T lymphocytopenia (HP:0005403)1.64653516
147Rimmed vacuoles (HP:0003805)1.64269589
148Nephroblastoma (Wilms tumor) (HP:0002667)1.64228353
149Polymicrogyria (HP:0002126)1.63636339
150Hypoplastic iliac wings (HP:0002866)1.63360842
151Trigonocephaly (HP:0000243)1.62593634
152Abnormality of midbrain morphology (HP:0002418)1.62508611
153Male pseudohermaphroditism (HP:0000037)1.62308602
154Broad-based gait (HP:0002136)1.61870813
155Supernumerary bones of the axial skeleton (HP:0009144)1.61727304
156Abnormality of the antihelix (HP:0009738)1.60297416
157Gonadal dysgenesis (HP:0000133)1.59967805
158Abnormal rod and cone electroretinograms (HP:0008323)1.59596180
159Supernumerary ribs (HP:0005815)1.58446981
160Anomalous pulmonary venous return (HP:0010772)1.54660266
161Abnormality of the pulmonary veins (HP:0011718)1.53926691
162Sleep apnea (HP:0010535)1.53744935
163Limited hip movement (HP:0008800)1.53710233
164Supernumerary spleens (HP:0009799)1.53290039
165Embryonal renal neoplasm (HP:0011794)1.52994010
166Intellectual disability, moderate (HP:0002342)1.51806699
167Renal agenesis (HP:0000104)1.50805168
168Renal hypoplasia (HP:0000089)1.50272452
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.49939010
170Absent forearm bone (HP:0003953)1.49338640
171Aplasia involving forearm bones (HP:0009822)1.49338640
172Abnormality of the intervertebral disk (HP:0005108)1.49282977
173Aplasia involving bones of the upper limbs (HP:0009823)1.48939288
174Aplasia of the phalanges of the hand (HP:0009802)1.48939288
175Aplasia involving bones of the extremities (HP:0009825)1.48939288
176Cutaneous finger syndactyly (HP:0010554)1.48364958
177Mixed hearing impairment (HP:0000410)1.47890483
178Bony spicule pigmentary retinopathy (HP:0007737)1.47724250
179Concave nail (HP:0001598)1.47556704
180Acute lymphatic leukemia (HP:0006721)1.46186963
181Absent radius (HP:0003974)1.45535605
182Tubulointerstitial nephritis (HP:0001970)1.45514671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.83332745
2MKNK23.85602856
3MAP3K43.76986810
4MARK13.06940565
5MAP2K72.81637892
6WNK32.78125067
7MKNK12.57226514
8TLK12.50680742
9BRD42.50450900
10TNIK2.49054287
11FRK2.37382484
12PRPF4B2.15684152
13CLK12.03091302
14TRIM281.95914204
15GRK11.84677399
16ERBB31.82490982
17TIE11.79389803
18TXK1.69425823
19BLK1.60822911
20CDK121.60490081
21PHKG21.56979894
22PHKG11.56979894
23EPHA41.54329651
24CAMKK21.52393697
25CAMK1G1.47429747
26MAP3K61.44789633
27TAOK31.41064588
28PKN11.40011896
29NUAK11.38534080
30IRAK41.36074889
31SRPK11.35297906
32MAP3K101.33030269
33MAP2K41.32565301
34MAP4K21.32006476
35INSRR1.30742484
36YES11.29107822
37SIK31.28554813
38CSNK1G21.25493984
39CDK31.24390676
40NEK61.23542775
41MAPK131.18806256
42DMPK1.14260549
43NLK1.14106705
44MUSK1.12012786
45BMPR1B1.09983031
46MAPK151.08274771
47IRAK21.06546319
48CSNK1G31.06458125
49FES1.06376680
50CDK91.03269768
51UHMK11.01969984
52PRKD20.97923614
53FGFR30.97072199
54CDK80.96928705
55VRK10.96322118
56DYRK1B0.96009057
57PAK30.95603191
58CAMK1D0.95496836
59IRAK10.94983938
60FGFR20.94615236
61DYRK30.93442767
62TEC0.92132761
63MARK20.90739078
64SIK20.89791752
65HIPK20.88884692
66RPS6KA40.88795787
67PNCK0.85741446
68EPHA30.85709582
69OBSCN0.85272730
70PRKAA20.85002835
71KSR10.84566152
72KIT0.83091069
73PLK20.81889838
74EIF2AK20.79672198
75CDK190.75783020
76DYRK1A0.74342356
77STK390.73444571
78RPS6KA50.73402427
79WNK10.73253749
80NTRK20.70683544
81ADRBK20.69532669
82PINK10.69357738
83MELK0.69218313
84IKBKE0.68509776
85GRK70.67541705
86CSNK1A1L0.67116717
87MAP3K140.66487247
88MAP3K50.65904160
89DYRK20.65729061
90STK160.64776130
91ERBB20.64466426
92EPHB10.64083405
93TGFBR20.62367950
94FGR0.62115604
95ACVR1B0.62044314
96BTK0.59273976
97ZAK0.59121374
98ATM0.59045458
99MAPKAPK50.58636890
100PRKG10.58012426
101ATR0.56896081
102BCR0.56356227
103CCNB10.55987866
104EGFR0.55463439
105CSNK1G10.54151279
106CDK50.53805560
107EPHB20.53095069
108ROCK20.52687359
109TNK20.52297005
110SYK0.50871223
111BMPR20.49657678
112STK100.49124881
113MINK10.49007247
114LCK0.48709042
115HCK0.47760536
116CDK70.47556356
117TRPM70.47531184
118PLK40.46699721
119MAPK100.45932533
120CDC70.45720233
121STK38L0.45375486
122CAMK40.45206662
123LATS10.45015181
124PRKCQ0.44434173
125SGK20.43767818
126OXSR10.43389238
127SGK4940.43353642
128SGK2230.43353642
129FER0.41553002
130MAP4K10.41260704
131CSK0.41149820
132CAMK10.40804014
133LYN0.40772605
134MAPK90.40612945
135PRKAA10.39952009
136STK110.39287956
137PIK3CA0.39214981
138CSNK1D0.39071068
139MAP3K70.38166212
140PRKCE0.38041994
141CAMK2A0.36717911
142SGK30.35919803
143PRKACB0.35557067
144GSK3B0.34414208
145CDK60.34026232

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.58138401
2Fanconi anemia pathway_Homo sapiens_hsa034602.11803444
3Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.73742569
4Axon guidance_Homo sapiens_hsa043601.66211846
5Primary immunodeficiency_Homo sapiens_hsa053401.62976618
6Notch signaling pathway_Homo sapiens_hsa043301.55491752
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55152149
8Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52623281
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49242114
10Nicotine addiction_Homo sapiens_hsa050331.43806162
11Dopaminergic synapse_Homo sapiens_hsa047281.42943995
12Basal cell carcinoma_Homo sapiens_hsa052171.42600752
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41089912
14Non-homologous end-joining_Homo sapiens_hsa034501.34635622
15Wnt signaling pathway_Homo sapiens_hsa043101.29275218
16Alcoholism_Homo sapiens_hsa050341.29198415
17Regulation of autophagy_Homo sapiens_hsa041401.29105267
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20026702
19Taste transduction_Homo sapiens_hsa047421.19901294
20MicroRNAs in cancer_Homo sapiens_hsa052061.18662063
21Ether lipid metabolism_Homo sapiens_hsa005651.18274408
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17949614
23Homologous recombination_Homo sapiens_hsa034401.17302576
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17135727
25Long-term depression_Homo sapiens_hsa047301.14747788
26Hedgehog signaling pathway_Homo sapiens_hsa043401.13382087
27Glutamatergic synapse_Homo sapiens_hsa047241.12857658
28Basal transcription factors_Homo sapiens_hsa030221.12204243
29Sphingolipid metabolism_Homo sapiens_hsa006001.11497320
30Morphine addiction_Homo sapiens_hsa050321.11377823
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11009797
32Hematopoietic cell lineage_Homo sapiens_hsa046401.09491373
33T cell receptor signaling pathway_Homo sapiens_hsa046601.08111360
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07506721
35Serotonergic synapse_Homo sapiens_hsa047261.06975757
36Oocyte meiosis_Homo sapiens_hsa041141.05057643
37Dorso-ventral axis formation_Homo sapiens_hsa043201.03554779
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.01724498
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00810153
40B cell receptor signaling pathway_Homo sapiens_hsa046620.99226450
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98934889
42FoxO signaling pathway_Homo sapiens_hsa040680.98056498
43Melanogenesis_Homo sapiens_hsa049160.97987310
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97856093
45Choline metabolism in cancer_Homo sapiens_hsa052310.97292793
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96765077
47Spliceosome_Homo sapiens_hsa030400.95265529
48Ras signaling pathway_Homo sapiens_hsa040140.93514783
49RNA degradation_Homo sapiens_hsa030180.90849960
50ErbB signaling pathway_Homo sapiens_hsa040120.89289946
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89192790
52Propanoate metabolism_Homo sapiens_hsa006400.89121174
53Calcium signaling pathway_Homo sapiens_hsa040200.88729354
54MAPK signaling pathway_Homo sapiens_hsa040100.88295580
55Endometrial cancer_Homo sapiens_hsa052130.86770784
56Autoimmune thyroid disease_Homo sapiens_hsa053200.85199724
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84213596
58Hippo signaling pathway_Homo sapiens_hsa043900.83832869
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83599689
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.83572607
61Amphetamine addiction_Homo sapiens_hsa050310.82337107
62Pathways in cancer_Homo sapiens_hsa052000.81126501
63Circadian entrainment_Homo sapiens_hsa047130.80362325
64cAMP signaling pathway_Homo sapiens_hsa040240.79694099
65mRNA surveillance pathway_Homo sapiens_hsa030150.79529382
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78965453
67Lysine degradation_Homo sapiens_hsa003100.76677868
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.75909126
69Gap junction_Homo sapiens_hsa045400.75896115
70Butanoate metabolism_Homo sapiens_hsa006500.75887253
71Measles_Homo sapiens_hsa051620.75757429
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75707580
73Circadian rhythm_Homo sapiens_hsa047100.75511225
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75354164
75Prostate cancer_Homo sapiens_hsa052150.75269869
76Salivary secretion_Homo sapiens_hsa049700.75265112
77Renin secretion_Homo sapiens_hsa049240.74938841
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74448404
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74176469
80Renal cell carcinoma_Homo sapiens_hsa052110.74052525
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.73963093
82Cocaine addiction_Homo sapiens_hsa050300.71816865
83Herpes simplex infection_Homo sapiens_hsa051680.71670710
84Chemokine signaling pathway_Homo sapiens_hsa040620.71648023
85Ovarian steroidogenesis_Homo sapiens_hsa049130.71377973
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71202119
87RNA transport_Homo sapiens_hsa030130.70000666
88Cell cycle_Homo sapiens_hsa041100.69998319
89Rap1 signaling pathway_Homo sapiens_hsa040150.69528296
90Type II diabetes mellitus_Homo sapiens_hsa049300.68453327
91Melanoma_Homo sapiens_hsa052180.68383745
92Prolactin signaling pathway_Homo sapiens_hsa049170.67982124
93Steroid biosynthesis_Homo sapiens_hsa001000.67858912
94Olfactory transduction_Homo sapiens_hsa047400.66622796
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66046013
96Viral carcinogenesis_Homo sapiens_hsa052030.65217020
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64733723
98HTLV-I infection_Homo sapiens_hsa051660.64646927
99Oxytocin signaling pathway_Homo sapiens_hsa049210.64501528
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64118110
101TGF-beta signaling pathway_Homo sapiens_hsa043500.63898488
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63884550
103Colorectal cancer_Homo sapiens_hsa052100.63639033
104AMPK signaling pathway_Homo sapiens_hsa041520.63549805
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.62744525
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62602151
107GnRH signaling pathway_Homo sapiens_hsa049120.62595875
108Platelet activation_Homo sapiens_hsa046110.62501637
109Acute myeloid leukemia_Homo sapiens_hsa052210.62434275
110Hepatitis B_Homo sapiens_hsa051610.62409245
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62311960
112Arachidonic acid metabolism_Homo sapiens_hsa005900.62311623
113Systemic lupus erythematosus_Homo sapiens_hsa053220.62031293
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61791742
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.61348172
116Cholinergic synapse_Homo sapiens_hsa047250.61227291
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.59812671
118Adherens junction_Homo sapiens_hsa045200.59638453
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59628114
120Dilated cardiomyopathy_Homo sapiens_hsa054140.59253512
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.58676309
122Inositol phosphate metabolism_Homo sapiens_hsa005620.58403799
123Base excision repair_Homo sapiens_hsa034100.58290103
124Osteoclast differentiation_Homo sapiens_hsa043800.58061019
125Long-term potentiation_Homo sapiens_hsa047200.57924706
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57680188
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56684557
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56600625
129GABAergic synapse_Homo sapiens_hsa047270.56368888
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56001792
131Other glycan degradation_Homo sapiens_hsa005110.55822698
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55718943
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55236362
134Viral myocarditis_Homo sapiens_hsa054160.50410619
135Mismatch repair_Homo sapiens_hsa034300.47397865
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46814881
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45378101
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44755831
139Tight junction_Homo sapiens_hsa045300.44076304

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