ATF7IP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.67508279
2metaphase plate congression (GO:0051310)5.55693916
3protein localization to kinetochore (GO:0034501)5.00816426
4piRNA metabolic process (GO:0034587)5.00697040
5nuclear pore complex assembly (GO:0051292)4.98490948
6synaptonemal complex assembly (GO:0007130)4.98130914
7nuclear pore organization (GO:0006999)4.97215040
8DNA replication checkpoint (GO:0000076)4.74055058
9protein localization to chromosome, centromeric region (GO:0071459)4.70076707
10synaptonemal complex organization (GO:0070193)4.63296574
11establishment of chromosome localization (GO:0051303)4.50410041
12microtubule depolymerization (GO:0007019)4.44425791
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42924863
14meiotic chromosome segregation (GO:0045132)4.39767727
15protein K6-linked ubiquitination (GO:0085020)4.37710186
16chromatin remodeling at centromere (GO:0031055)4.35276293
17regulation of spindle organization (GO:0090224)4.33510331
18histone exchange (GO:0043486)4.33313164
19male meiosis (GO:0007140)4.24661113
20attachment of spindle microtubules to kinetochore (GO:0008608)4.22477440
21CENP-A containing nucleosome assembly (GO:0034080)4.20986370
22purine nucleobase biosynthetic process (GO:0009113)4.20454766
23male meiosis I (GO:0007141)4.15631145
24mitotic chromosome condensation (GO:0007076)4.15371198
25meiosis I (GO:0007127)4.06557405
26regulation of meiosis I (GO:0060631)4.04012409
27kinetochore organization (GO:0051383)4.01227166
28DNA replication-dependent nucleosome assembly (GO:0006335)3.97198223
29DNA replication-dependent nucleosome organization (GO:0034723)3.97198223
30positive regulation of gamma-delta T cell activation (GO:0046645)3.96910270
31DNA replication-independent nucleosome organization (GO:0034724)3.95447244
32DNA replication-independent nucleosome assembly (GO:0006336)3.95447244
33positive regulation of chromosome segregation (GO:0051984)3.94125300
34kinetochore assembly (GO:0051382)3.93789612
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.92493570
36positive regulation of B cell differentiation (GO:0045579)3.90719620
37monoubiquitinated protein deubiquitination (GO:0035520)3.90406701
38meiotic nuclear division (GO:0007126)3.90071178
39DNA deamination (GO:0045006)3.89346993
40DNA replication initiation (GO:0006270)3.89063248
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88481492
42mitotic sister chromatid segregation (GO:0000070)3.87418536
43mitotic nuclear envelope disassembly (GO:0007077)3.84802505
44nucleobase biosynthetic process (GO:0046112)3.84009564
45pore complex assembly (GO:0046931)3.81238588
46ribosome biogenesis (GO:0042254)3.79140246
47regulation of mitotic spindle organization (GO:0060236)3.78569125
48chromosome organization involved in meiosis (GO:0070192)3.76569916
49regulation of chromosome segregation (GO:0051983)3.75838291
50DNA methylation involved in gamete generation (GO:0043046)3.75475954
51ribosome assembly (GO:0042255)3.75036851
52spindle checkpoint (GO:0031577)3.66194441
53protein localization to chromosome (GO:0034502)3.65706011
54maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64837189
55meiotic cell cycle process (GO:1903046)3.62342990
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.62284102
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62284102
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62284102
59nuclear envelope disassembly (GO:0051081)3.58870377
60membrane disassembly (GO:0030397)3.58870377
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.54168263
62reciprocal meiotic recombination (GO:0007131)3.50474167
63reciprocal DNA recombination (GO:0035825)3.50474167
64mitotic sister chromatid cohesion (GO:0007064)3.48022448
65resolution of meiotic recombination intermediates (GO:0000712)3.46166280
66maturation of 5.8S rRNA (GO:0000460)3.45969607
67inner cell mass cell proliferation (GO:0001833)3.45226272
68sister chromatid cohesion (GO:0007062)3.41729911
69chromosome segregation (GO:0007059)3.39384671
70regulation of RNA export from nucleus (GO:0046831)3.39360829
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38708545
72negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.37599420
73RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.35404834
74regulation of centrosome cycle (GO:0046605)3.34404280
75mast cell activation involved in immune response (GO:0002279)3.33684594
76mast cell degranulation (GO:0043303)3.33684594
77rRNA modification (GO:0000154)3.33402539
78regulation of sister chromatid cohesion (GO:0007063)3.33263895
79sister chromatid segregation (GO:0000819)3.33022805
80negative regulation of chromosome segregation (GO:0051985)3.32267087
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31761401
82regulation of helicase activity (GO:0051095)3.30399615
83regulation of B cell receptor signaling pathway (GO:0050855)3.29347895
84histone H2A monoubiquitination (GO:0035518)3.28142312
85mitotic spindle checkpoint (GO:0071174)3.26900483
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26647217
87negative regulation of sister chromatid segregation (GO:0033046)3.26647217
88negative regulation of mitotic sister chromatid separation (GO:2000816)3.26647217
89negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26647217
90regulation of centriole replication (GO:0046599)3.22699765
91regulation of mitotic sister chromatid separation (GO:0010965)3.21428787
92regulation of mitotic sister chromatid segregation (GO:0033047)3.21428787
93regulation of sister chromatid segregation (GO:0033045)3.21428787
94spindle assembly checkpoint (GO:0071173)3.20901091
95negative regulation of DNA-dependent DNA replication (GO:2000104)3.20809330
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18011540
97DNA synthesis involved in DNA repair (GO:0000731)3.16243678
98regulation of alpha-beta T cell proliferation (GO:0046640)3.16204475
99mitotic spindle assembly checkpoint (GO:0007094)3.15436301
100ATP-dependent chromatin remodeling (GO:0043044)3.13926681
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.13819788
102chromatin assembly or disassembly (GO:0006333)3.11403603
103mast cell activation (GO:0045576)3.11097652
104regulation of telomere maintenance via telomerase (GO:0032210)3.10993346
105DNA strand elongation involved in DNA replication (GO:0006271)3.06891290
106regulation of posttranscriptional gene silencing (GO:0060147)3.05187332
107regulation of gene silencing by miRNA (GO:0060964)3.05187332
108regulation of gene silencing by RNA (GO:0060966)3.05187332
109positive regulation of granulocyte differentiation (GO:0030854)3.04840532
110termination of RNA polymerase I transcription (GO:0006363)3.03712212
111purine deoxyribonucleotide catabolic process (GO:0009155)3.03146803
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02885777
113positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02465958
114regulation of spindle checkpoint (GO:0090231)3.02160446
115regulation of B cell differentiation (GO:0045577)2.96737040
116regulation of gamma-delta T cell differentiation (GO:0045586)2.90328613
117regulation of germinal center formation (GO:0002634)2.90108613
118rRNA catabolic process (GO:0016075)2.87955805
119mannosylation (GO:0097502)2.83689275
120tryptophan catabolic process (GO:0006569)2.83273342
121indole-containing compound catabolic process (GO:0042436)2.83273342
122indolalkylamine catabolic process (GO:0046218)2.83273342
123protein complex biogenesis (GO:0070271)2.81809226
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76674674
125regulation of gamma-delta T cell activation (GO:0046643)2.75422410
126positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.74927952
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73653944
128purinergic nucleotide receptor signaling pathway (GO:0035590)2.72982738
129organelle membrane fusion (GO:0090174)2.72656304
130positive regulation of defense response to virus by host (GO:0002230)2.72600411
131mitochondrial respiratory chain complex assembly (GO:0033108)2.71247379
132ATP synthesis coupled proton transport (GO:0015986)2.69248547
133energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69248547
134Peyers patch development (GO:0048541)2.69083422
135mucosal-associated lymphoid tissue development (GO:0048537)2.69083422
136tryptophan metabolic process (GO:0006568)2.66690509
137base-excision repair, AP site formation (GO:0006285)2.66065987
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.65435057
139NADH dehydrogenase complex assembly (GO:0010257)2.65435057
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65435057
141regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.63035213
142autophagic vacuole fusion (GO:0000046)2.61567339
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61145116
144synapsis (GO:0007129)2.59802645
145intra-S DNA damage checkpoint (GO:0031573)2.58359490
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.56088236
147tolerance induction (GO:0002507)2.55342737
148purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.54497089
149negative T cell selection (GO:0043383)2.54299215
150indolalkylamine metabolic process (GO:0006586)2.53479169
151proteasome assembly (GO:0043248)2.52501710
152adenosine metabolic process (GO:0046085)2.52257010
153B cell receptor signaling pathway (GO:0050853)2.51286977
154preassembly of GPI anchor in ER membrane (GO:0016254)2.51163466
155GPI anchor metabolic process (GO:0006505)2.49619099
156positive regulation of histone H3-K4 methylation (GO:0051571)2.49531459
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49189478
158deoxyribose phosphate catabolic process (GO:0046386)2.49163681
159response to interferon-beta (GO:0035456)2.48952906
160cellular response to exogenous dsRNA (GO:0071360)2.47697244
161GPI anchor biosynthetic process (GO:0006506)2.47677140
162centriole replication (GO:0007099)2.46722501
163cytochrome complex assembly (GO:0017004)2.45904442
164cellular response to interferon-beta (GO:0035458)2.45671434
165regulation of hypersensitivity (GO:0002883)2.45457211
166purine deoxyribonucleotide metabolic process (GO:0009151)2.44652931
167negative thymic T cell selection (GO:0045060)2.43823057
168regulation of regulatory T cell differentiation (GO:0045589)2.43704297
169deoxyribonucleotide catabolic process (GO:0009264)2.42864112
170axoneme assembly (GO:0035082)2.42859453
171leukocyte degranulation (GO:0043299)2.42799566
172regulation of T-helper 1 cell differentiation (GO:0045625)2.42347582
173regulation of female gonad development (GO:2000194)2.38137134
174regulation of B cell apoptotic process (GO:0002902)2.37526944
175purine-containing compound salvage (GO:0043101)2.37409602
176cilium or flagellum-dependent cell motility (GO:0001539)2.37019860
177purine nucleotide salvage (GO:0032261)2.36777109
178L-fucose catabolic process (GO:0042355)2.36002544
179fucose catabolic process (GO:0019317)2.36002544
180L-fucose metabolic process (GO:0042354)2.36002544
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.35131133
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.35131133
183epithelial cilium movement (GO:0003351)2.32894652
184negative regulation of thymocyte apoptotic process (GO:0070244)2.32682457
185regulation of T cell receptor signaling pathway (GO:0050856)2.31156857
186ubiquinone biosynthetic process (GO:0006744)2.30804484
187neural tube formation (GO:0001841)2.30290559
188regulation of memory T cell differentiation (GO:0043380)2.30093027
189positive regulation of T cell differentiation in thymus (GO:0033089)2.29482427
190respiratory chain complex IV assembly (GO:0008535)2.29281918
191positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.27126165
192positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26866393
193positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.26762500
194histamine secretion (GO:0001821)2.19903401
195T cell migration (GO:0072678)2.19594366
196response to pheromone (GO:0019236)2.19252023
197recombinational repair (GO:0000725)2.18552529
198double-strand break repair via homologous recombination (GO:0000724)2.18437459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75588622
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.30245712
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.46357302
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.45372208
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.27195820
6E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04059756
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69273685
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.57314374
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82813214
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82794694
11AR_21909140_ChIP-Seq_LNCAP_Human2.77150369
12ZNF274_21170338_ChIP-Seq_K562_Hela2.71489845
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71153438
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65691641
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.60660173
16VDR_22108803_ChIP-Seq_LS180_Human2.57088853
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55341574
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49611063
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48691083
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38224591
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.38055440
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.33081444
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.32450636
24IGF1R_20145208_ChIP-Seq_DFB_Human2.28316047
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25801840
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25108694
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25103106
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24469922
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17661693
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16002757
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15114482
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11657119
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.08924393
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07718568
35MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07443124
36NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04220203
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03378603
38E2F1_21310950_ChIP-Seq_MCF-7_Human2.00401118
39XRN2_22483619_ChIP-Seq_HELA_Human1.91943306
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91635072
41VDR_23849224_ChIP-Seq_CD4+_Human1.90854043
42MYB_26560356_Chip-Seq_TH2_Human1.86477425
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.85111206
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81548814
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78944740
46GATA3_26560356_Chip-Seq_TH2_Human1.75248279
47* EWS_26573619_Chip-Seq_HEK293_Human1.73460361
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72834664
49RUNX_20019798_ChIP-Seq_JUKART_Human1.72208675
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.67233272
51* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.66767455
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66580877
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63659517
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60297933
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58652308
56FUS_26573619_Chip-Seq_HEK293_Human1.57534746
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57210357
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56924471
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55921138
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55614295
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55614295
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55614295
63FOXP3_21729870_ChIP-Seq_TREG_Human1.54526780
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54251506
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.50209525
66GATA1_22025678_ChIP-Seq_K562_Human1.50037719
67TAF15_26573619_Chip-Seq_HEK293_Human1.48593594
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47025457
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45329519
70DCP1A_22483619_ChIP-Seq_HELA_Human1.45164168
71GABP_19822575_ChIP-Seq_HepG2_Human1.45144845
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44938648
73GATA3_27048872_Chip-Seq_THYMUS_Human1.44163037
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40826519
75SCL_19346495_ChIP-Seq_HPC-7_Human1.40665411
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39713603
77TTF2_22483619_ChIP-Seq_HELA_Human1.39364669
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38935194
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38499168
80ER_23166858_ChIP-Seq_MCF-7_Human1.38027882
81* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37914161
82* FOXA1_25329375_ChIP-Seq_VCAP_Human1.37914161
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37348815
84KDM5A_27292631_Chip-Seq_BREAST_Human1.35881131
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.34667879
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34155766
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32521850
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.32398239
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31604408
90TP53_22573176_ChIP-Seq_HFKS_Human1.31569698
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30646843
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.29822959
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29667775
94ELK1_19687146_ChIP-ChIP_HELA_Human1.28557375
95IRF1_19129219_ChIP-ChIP_H3396_Human1.27301642
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.26938804
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25879554
98BP1_19119308_ChIP-ChIP_Hs578T_Human1.25782036
99NANOG_19829295_ChIP-Seq_ESCs_Human1.24033992
100SOX2_19829295_ChIP-Seq_ESCs_Human1.24033992
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23213575
102SPI1_23547873_ChIP-Seq_NB4_Human1.21761326
103P300_19829295_ChIP-Seq_ESCs_Human1.21041047
104* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20020167
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19413203
106* AR_20517297_ChIP-Seq_VCAP_Human1.19404364
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16218691
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15556637
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15275855
110CBP_20019798_ChIP-Seq_JUKART_Human1.14922918
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14922918
112MYB_26560356_Chip-Seq_TH1_Human1.14422041
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14054319
114* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13657436
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12084421
116* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11757802
117EGR1_19374776_ChIP-ChIP_THP-1_Human1.11460184
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.10650798
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.10335336
120TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09362721
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.08687053
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08521310
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.07479626
124IRF8_27001747_Chip-Seq_BMDM_Mouse1.06228413
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05854272
126SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04539502
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04300879
128* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04071055
129RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03906111
130GATA3_26560356_Chip-Seq_TH1_Human1.03664422
131TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03184930
132NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02891190
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01686497
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99013544
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98999285
136STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98394632
137TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96731316
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96102296
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95751787
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.95655049
141MYC_18940864_ChIP-ChIP_HL60_Human0.94841963
142NCOR_22424771_ChIP-Seq_293T_Human0.93607821
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92935800
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.92306908
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92271829
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91388121
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90875806
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90399900
149GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90282658
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90132296
151GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90060067
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.89884930
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89617641
154* KAP1_27257070_Chip-Seq_ESCs_Mouse0.89151022
155ETV1_20927104_ChIP-Seq_GIST48_Human0.89113370
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84116505
157HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83668627
158NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83476032
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83318828
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82011474
161POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81868175
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81292423
163NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81239225
164NOTCH1_21737748_ChIP-Seq_TLL_Human0.80977172
165ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79921548
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79788741
167SRF_21415370_ChIP-Seq_HL-1_Mouse0.79700145
168NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77097517
169CIITA_25753668_ChIP-Seq_RAJI_Human0.76131715
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75073746
171SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74253117
172SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74221589
173SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.74084073
174SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73217368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.37468602
2MP0008057_abnormal_DNA_replication4.67418622
3MP0003111_abnormal_nucleus_morphology4.49704409
4MP0010094_abnormal_chromosome_stability4.43852526
5MP0008877_abnormal_DNA_methylation4.39101717
6MP0004957_abnormal_blastocyst_morpholog3.93671644
7MP0003077_abnormal_cell_cycle3.92333141
8MP0008058_abnormal_DNA_repair3.70247786
9MP0004147_increased_porphyrin_level3.37774213
10MP0008007_abnormal_cellular_replicative3.07615781
11MP0005671_abnormal_response_to3.01301893
12MP0003123_paternal_imprinting2.68498847
13MP0001835_abnormal_antigen_presentation2.67829337
14MP0003718_maternal_effect2.62810345
15MP0010307_abnormal_tumor_latency2.57713867
16MP0002210_abnormal_sex_determination2.55658088
17MP0001929_abnormal_gametogenesis2.52515612
18MP0001730_embryonic_growth_arrest2.43272820
19MP0008932_abnormal_embryonic_tissue2.41093401
20MP0002138_abnormal_hepatobiliary_system2.33381738
21MP0001800_abnormal_humoral_immune2.30805012
22MP0003195_calcinosis2.28507759
23MP0003786_premature_aging2.27996502
24MP0005410_abnormal_fertilization2.26790642
25MP0003724_increased_susceptibility_to2.23885652
26MP0000350_abnormal_cell_proliferation2.16663429
27MP0001145_abnormal_male_reproductive2.16044853
28MP0005646_abnormal_pituitary_gland2.08844934
29MP0000653_abnormal_sex_gland1.99265371
30MP0005000_abnormal_immune_tolerance1.96929070
31MP0006292_abnormal_olfactory_placode1.95755678
32MP0003698_abnormal_male_reproductive1.95526110
33MP0005380_embryogenesis_phenotype1.92147737
34MP0001672_abnormal_embryogenesis/_devel1.92147737
35MP0003763_abnormal_thymus_physiology1.91578514
36MP0005075_abnormal_melanosome_morpholog1.91464305
37MP0002148_abnormal_hypersensitivity_rea1.90180274
38MP0002723_abnormal_immune_serum1.84905950
39MP0002452_abnormal_antigen_presenting1.79137015
40MP0008875_abnormal_xenobiotic_pharmacok1.77415415
41MP0002139_abnormal_hepatobiliary_system1.74084263
42MP0003315_abnormal_perineum_morphology1.73755321
43MP0001790_abnormal_immune_system1.72167637
44MP0005387_immune_system_phenotype1.72167637
45MP0002653_abnormal_ependyma_morphology1.71751946
46MP0009785_altered_susceptibility_to1.71494058
47MP0002085_abnormal_embryonic_tissue1.70513843
48MP0001697_abnormal_embryo_size1.69351311
49MP0000372_irregular_coat_pigmentation1.68899515
50MP0009697_abnormal_copulation1.68025804
51MP0002132_abnormal_respiratory_system1.67290164
52MP0002084_abnormal_developmental_patter1.66672385
53MP0001819_abnormal_immune_cell1.66115607
54MP0002420_abnormal_adaptive_immunity1.65401273
55MP0008995_early_reproductive_senescence1.63242667
56MP0002398_abnormal_bone_marrow1.60465021
57MP0005084_abnormal_gallbladder_morpholo1.59232294
58MP0003984_embryonic_growth_retardation1.59118845
59MP0008872_abnormal_physiological_respon1.57619347
60MP0003656_abnormal_erythrocyte_physiolo1.54430086
61MP0003890_abnormal_embryonic-extraembry1.54283260
62MP0002088_abnormal_embryonic_growth/wei1.53598562
63MP0000689_abnormal_spleen_morphology1.52875249
64MP0009333_abnormal_splenocyte_physiolog1.50860358
65MP0002160_abnormal_reproductive_system1.50477450
66MP0005464_abnormal_platelet_physiology1.45554703
67MP0001764_abnormal_homeostasis1.44753964
68MP0002009_preneoplasia1.43926230
69MP0000716_abnormal_immune_system1.42005622
70MP0002080_prenatal_lethality1.39256411
71MP0003941_abnormal_skin_development1.37637947
72MP0009764_decreased_sensitivity_to1.36676059
73MP0003436_decreased_susceptibility_to1.35595558
74MP0002161_abnormal_fertility/fecundity1.35155850
75MP0010234_abnormal_vibrissa_follicle1.34657327
76MP0002086_abnormal_extraembryonic_tissu1.34467773
77MP0001119_abnormal_female_reproductive1.34239132
78MP0006036_abnormal_mitochondrial_physio1.33107218
79MP0002166_altered_tumor_susceptibility1.31642169
80MP0003252_abnormal_bile_duct1.31144759
81MP0005076_abnormal_cell_differentiation1.30434584
82MP0003121_genomic_imprinting1.29079096
83MP0003937_abnormal_limbs/digits/tail_de1.28565890
84MP0005025_abnormal_response_to1.26384781
85MP0002405_respiratory_system_inflammati1.24516838
86MP0002722_abnormal_immune_system1.24291458
87MP0004197_abnormal_fetal_growth/weight/1.23605930
88MP0000685_abnormal_immune_system1.22489591
89MP0010352_gastrointestinal_tract_polyps1.21439224
90MP0002419_abnormal_innate_immunity1.20183253
91MP0002429_abnormal_blood_cell1.18627355
92MP0001293_anophthalmia1.16632448
93MP0000313_abnormal_cell_death1.15767550
94MP0001873_stomach_inflammation1.15597236
95MP0002396_abnormal_hematopoietic_system1.14872257
96MP0002006_tumorigenesis1.11739213
97MP0005085_abnormal_gallbladder_physiolo1.11128177
98MP0005389_reproductive_system_phenotype1.10008909
99MP0006072_abnormal_retinal_apoptosis1.07988561
100MP0003136_yellow_coat_color1.07625690
101MP0002876_abnormal_thyroid_physiology1.06791731
102MP0000703_abnormal_thymus_morphology1.06665493
103MP0002837_dystrophic_cardiac_calcinosis1.06446144
104MP0003699_abnormal_female_reproductive1.06290772
105MP0010155_abnormal_intestine_physiology1.04622023
106MP0003119_abnormal_digestive_system1.04374476
107MP0001845_abnormal_inflammatory_respons1.03469009
108MP0002102_abnormal_ear_morphology1.02389722
109MP0008469_abnormal_protein_level1.01519495
110MP0008004_abnormal_stomach_pH1.01388149
111MP0003787_abnormal_imprinting1.00209677
112MP0005636_abnormal_mineral_homeostasis0.99362592
113MP0002019_abnormal_tumor_incidence0.98054011
114MP0005551_abnormal_eye_electrophysiolog0.97259396
115MP0000465_gastrointestinal_hemorrhage0.95400130
116MP0009278_abnormal_bone_marrow0.94707047
117MP0002277_abnormal_respiratory_mucosa0.94021328
118MP0001986_abnormal_taste_sensitivity0.90928902
119MP0004142_abnormal_muscle_tone0.90352685
120MP0001853_heart_inflammation0.90298094
121MP0005395_other_phenotype0.90294652
122MP0005451_abnormal_body_composition0.89981237
123MP0005167_abnormal_blood-brain_barrier0.89191110
124MP0002163_abnormal_gland_morphology0.89128306
125MP0003567_abnormal_fetal_cardiomyocyte0.88693725
126MP0005253_abnormal_eye_physiology0.87743505
127MP0005379_endocrine/exocrine_gland_phen0.87620836
128MP0010329_abnormal_lipoprotein_level0.86822017
129MP0005365_abnormal_bile_salt0.86448199
130MP0003936_abnormal_reproductive_system0.86192230
131MP0005332_abnormal_amino_acid0.85542520
132MP0009672_abnormal_birth_weight0.84441605
133MP0010030_abnormal_orbit_morphology0.84182968
134MP0003186_abnormal_redox_activity0.82752077
135MP0003646_muscle_fatigue0.82612031
136MP0009703_decreased_birth_body0.81938639
137MP0000432_abnormal_head_morphology0.79757790
138MP0006082_CNS_inflammation0.78817050
139MP0001286_abnormal_eye_development0.77928799
140MP0001849_ear_inflammation0.77756999
141MP0006035_abnormal_mitochondrial_morpho0.76950692
142MP0001501_abnormal_sleep_pattern0.76510084
143MP0005621_abnormal_cell_physiology0.76251244
144MP0005645_abnormal_hypothalamus_physiol0.75747029
145MP0003755_abnormal_palate_morphology0.75356596
146MP0000569_abnormal_digit_pigmentation0.75345353
147MP0005647_abnormal_sex_gland0.75183317
148MP0000579_abnormal_nail_morphology0.74216011
149MP0003303_peritoneal_inflammation0.73866578
150MP0004133_heterotaxia0.73656468
151MP0000490_abnormal_crypts_of0.73095796
152MP0004215_abnormal_myocardial_fiber0.72294838
153MP0003950_abnormal_plasma_membrane0.71694869
154MP0002111_abnormal_tail_morphology0.71297668
155MP0004264_abnormal_extraembryonic_tissu0.70484084
156MP0000627_abnormal_mammary_gland0.70071401
157MP0005384_cellular_phenotype0.69291017
158MP0003938_abnormal_ear_development0.68463490
159MP0003806_abnormal_nucleotide_metabolis0.68301393
160MP0003221_abnormal_cardiomyocyte_apopto0.66195973
161MP0004808_abnormal_hematopoietic_stem0.65675838
162MP0003861_abnormal_nervous_system0.65654074
163MP0002092_abnormal_eye_morphology0.65020562
164MP0000428_abnormal_craniofacial_morphol0.62251025
165MP0000566_synostosis0.61811748
166MP0003283_abnormal_digestive_organ0.60789686
167MP0003935_abnormal_craniofacial_develop0.59854532
168MP0005187_abnormal_penis_morphology0.58998967
169MP0001919_abnormal_reproductive_system0.56651681
170MP0001661_extended_life_span0.56167530
171MP0002697_abnormal_eye_size0.56022709
172MP0001545_abnormal_hematopoietic_system0.55821668
173MP0005397_hematopoietic_system_phenotyp0.55821668
174MP0004185_abnormal_adipocyte_glucose0.55140244
175MP0000516_abnormal_urinary_system0.54984794
176MP0005367_renal/urinary_system_phenotyp0.54984794
177MP0010678_abnormal_skin_adnexa0.51903689
178MP0000462_abnormal_digestive_system0.51660071
179MP0005408_hypopigmentation0.48811105

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.62079762
2Chromsome breakage (HP:0040012)5.52583002
3Birth length less than 3rd percentile (HP:0003561)5.46105623
4Breast hypoplasia (HP:0003187)4.89511370
5Abnormality of the labia minora (HP:0012880)4.40916368
6Impulsivity (HP:0100710)4.32865931
7Meckel diverticulum (HP:0002245)3.98722897
8Abnormality of the preputium (HP:0100587)3.89210161
9Abnormality of chromosome stability (HP:0003220)3.88660723
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.83622745
11Supernumerary spleens (HP:0009799)3.80500524
12Aplasia/Hypoplasia of the uvula (HP:0010293)3.77568956
13Abnormal spermatogenesis (HP:0008669)3.77042623
14Abnormality of the ileum (HP:0001549)3.72301421
15Carpal bone hypoplasia (HP:0001498)3.72149198
16Patellar aplasia (HP:0006443)3.69834742
17Abnormality of B cell number (HP:0010975)3.63268231
18Azoospermia (HP:0000027)3.56790629
19Panhypogammaglobulinemia (HP:0003139)3.53720891
20Absent radius (HP:0003974)3.52473660
21Aplasia/Hypoplasia of the patella (HP:0006498)3.43447519
22Facial hemangioma (HP:0000329)3.42773394
23Absent forearm bone (HP:0003953)3.30368302
24Aplasia involving forearm bones (HP:0009822)3.30368302
25B lymphocytopenia (HP:0010976)3.24429957
26Severe combined immunodeficiency (HP:0004430)3.23613622
27Pancreatic cysts (HP:0001737)3.14869722
28Stomatitis (HP:0010280)3.11244082
29Autoimmune hemolytic anemia (HP:0001890)3.01047488
30Duodenal stenosis (HP:0100867)3.00145193
31Small intestinal stenosis (HP:0012848)3.00145193
32Ectopic kidney (HP:0000086)2.88073092
33Pancreatic fibrosis (HP:0100732)2.85554209
34Ependymoma (HP:0002888)2.84671179
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.80892201
36Oral leukoplakia (HP:0002745)2.80256803
37Stomach cancer (HP:0012126)2.78102386
38Agammaglobulinemia (HP:0004432)2.77502364
39Elevated erythrocyte sedimentation rate (HP:0003565)2.74405798
40Abnormality of the prostate (HP:0008775)2.69562461
41Breast aplasia (HP:0100783)2.68682672
42Horseshoe kidney (HP:0000085)2.63922062
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.63489918
44Absent thumb (HP:0009777)2.62800365
45Rough bone trabeculation (HP:0100670)2.62479213
46Oligodactyly (HP:0012165)2.62332905
47IgG deficiency (HP:0004315)2.62209735
48Abnormality of the renal cortex (HP:0011035)2.58834375
49Combined immunodeficiency (HP:0005387)2.58528475
50Shawl scrotum (HP:0000049)2.58285814
51Selective tooth agenesis (HP:0001592)2.56318937
52Aplasia/Hypoplasia of the breasts (HP:0010311)2.53728990
53Short thumb (HP:0009778)2.52047559
54Absent/shortened dynein arms (HP:0200106)2.51562208
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.51562208
56Molar tooth sign on MRI (HP:0002419)2.50014342
57Abnormality of midbrain morphology (HP:0002418)2.50014342
58Myelodysplasia (HP:0002863)2.49698381
59Medulloblastoma (HP:0002885)2.49099723
60Oligodactyly (hands) (HP:0001180)2.48789913
61Abolished electroretinogram (ERG) (HP:0000550)2.48439065
62True hermaphroditism (HP:0010459)2.48207131
63Capillary hemangiomas (HP:0005306)2.48085188
64Abnormality of T cells (HP:0002843)2.47380504
65Abnormality of the carotid arteries (HP:0005344)2.45877155
66Nephroblastoma (Wilms tumor) (HP:0002667)2.45528847
67Sloping forehead (HP:0000340)2.44734536
68Abnormality of the duodenum (HP:0002246)2.44578257
69Chronic bronchitis (HP:0004469)2.44483870
70Abnormal biliary tract physiology (HP:0012439)2.42534819
71Bile duct proliferation (HP:0001408)2.42534819
72Abnormality of T cell physiology (HP:0011840)2.41976559
73Thyroiditis (HP:0100646)2.41154677
74Rhabdomyosarcoma (HP:0002859)2.40451917
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39298475
76Bone marrow hypocellularity (HP:0005528)2.39009925
77Duplicated collecting system (HP:0000081)2.37797986
78Abnormal ciliary motility (HP:0012262)2.36690530
79Aplasia/hypoplasia of the humerus (HP:0006507)2.36119951
80Renal cortical cysts (HP:0000803)2.35858931
81Abnormal respiratory motile cilium physiology (HP:0012261)2.35536531
82Prostate neoplasm (HP:0100787)2.34486474
83Mitochondrial inheritance (HP:0001427)2.33109203
84Congenital stationary night blindness (HP:0007642)2.31946055
85Triphalangeal thumb (HP:0001199)2.31759760
86Aplasia/Hypoplasia of the sternum (HP:0006714)2.30934762
87Abnormal rod and cone electroretinograms (HP:0008323)2.30797755
88Abnormality of T cell number (HP:0011839)2.29613470
89Colon cancer (HP:0003003)2.29521857
90Cerebral hypomyelination (HP:0006808)2.29317395
91Tracheoesophageal fistula (HP:0002575)2.28887334
92Rhinitis (HP:0012384)2.28085777
93Acute necrotizing encephalopathy (HP:0006965)2.27953360
94Clubbing of toes (HP:0100760)2.27790990
95Type II lissencephaly (HP:0007260)2.27663120
96Abnormality of the anterior horn cell (HP:0006802)2.26448259
97Degeneration of anterior horn cells (HP:0002398)2.26448259
98Embryonal renal neoplasm (HP:0011794)2.26138137
99Neoplasm of the pancreas (HP:0002894)2.25877978
100Premature ovarian failure (HP:0008209)2.24772552
101Male infertility (HP:0003251)2.24253211
102Recurrent sinusitis (HP:0011108)2.22904722
103Abnormality of the heme biosynthetic pathway (HP:0010472)2.22253838
104T lymphocytopenia (HP:0005403)2.22045877
105Attenuation of retinal blood vessels (HP:0007843)2.21610056
106Papillary thyroid carcinoma (HP:0002895)2.21455491
1073-Methylglutaconic aciduria (HP:0003535)2.20193153
108IgM deficiency (HP:0002850)2.19119242
109Increased CSF lactate (HP:0002490)2.18821497
110Increased hepatocellular lipid droplets (HP:0006565)2.18666595
111Aplastic anemia (HP:0001915)2.18226186
112Acute encephalopathy (HP:0006846)2.16747469
113Abnormal lung lobation (HP:0002101)2.16285531
114Ureteral duplication (HP:0000073)2.15893876
115Abnormality of the lower motor neuron (HP:0002366)2.15001290
116Recurrent fungal infections (HP:0002841)2.12956664
117Nephronophthisis (HP:0000090)2.12665343
118Secondary amenorrhea (HP:0000869)2.12079051
119Reticulocytopenia (HP:0001896)2.09753161
120Abnormal respiratory motile cilium morphology (HP:0005938)2.08573638
121Abnormal respiratory epithelium morphology (HP:0012253)2.08573638
122Chronic hepatic failure (HP:0100626)2.08048694
123Abnormal mitochondria in muscle tissue (HP:0008316)2.05195186
124Chronic sinusitis (HP:0011109)2.04485266
125Encephalitis (HP:0002383)2.04091904
126Cafe-au-lait spot (HP:0000957)2.02367511
127Recurrent viral infections (HP:0004429)2.02098322
128Abnormality of the astrocytes (HP:0100707)2.01980038
129Astrocytoma (HP:0009592)2.01980038
130Abnormal trabecular bone morphology (HP:0100671)2.01650400
131Abnormality of the renal collecting system (HP:0004742)2.00627416
132Myositis (HP:0100614)2.00290789
133Abnormality of eosinophils (HP:0001879)1.99906438
134Neutropenia (HP:0001875)1.99714335
13511 pairs of ribs (HP:0000878)1.98877541
136Lipid accumulation in hepatocytes (HP:0006561)1.98130168
137Agnosia (HP:0010524)1.97876269
138Progressive macrocephaly (HP:0004481)1.97638018
139Type I transferrin isoform profile (HP:0003642)1.97468873
140Facial cleft (HP:0002006)1.97083931
141Prominent nose (HP:0000448)1.96959571
142Abnormality of lateral ventricle (HP:0030047)1.95246845
143Abnormality of the renal medulla (HP:0100957)1.95119612
144Squamous cell carcinoma (HP:0002860)1.93233984
145Vasculitis (HP:0002633)1.92980138
146Hypoproteinemia (HP:0003075)1.92542233
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92311564
148Hepatic necrosis (HP:0002605)1.92166896
149Hepatocellular necrosis (HP:0001404)1.91425224
150Short humerus (HP:0005792)1.91163398
151Decreased central vision (HP:0007663)1.91055732
152Autoimmune thrombocytopenia (HP:0001973)1.90900522
153Glioma (HP:0009733)1.90190440
154Decreased circulating renin level (HP:0003351)1.89962647
155Methylmalonic acidemia (HP:0002912)1.89908272
156Eosinophilia (HP:0001880)1.89831161
157Medial flaring of the eyebrow (HP:0010747)1.89587768
158Chronic otitis media (HP:0000389)1.89206200
159Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89201369
160Increased intramyocellular lipid droplets (HP:0012240)1.88875460
161Metaphyseal dysplasia (HP:0100255)1.85358038
162Meningitis (HP:0001287)1.85074192
163Cleft eyelid (HP:0000625)1.84609732
164Bronchiectasis (HP:0002110)1.84540348
165Neoplasm of the oral cavity (HP:0100649)1.84396057
166Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83418221
167Atresia of the external auditory canal (HP:0000413)1.83384363
168Hypokalemic alkalosis (HP:0001949)1.81187763
169Infertility (HP:0000789)1.80717194
170Biliary tract neoplasm (HP:0100574)1.80362318
171Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80165432
172Abnormal protein N-linked glycosylation (HP:0012347)1.80165432
173Abnormal protein glycosylation (HP:0012346)1.80165432
174Abnormal glycosylation (HP:0012345)1.80165432
175Arteriovenous malformation (HP:0100026)1.79895131
176Abnormal number of erythroid precursors (HP:0012131)1.79795622
177Stenosis of the external auditory canal (HP:0000402)1.79611076
178Granulocytopenia (HP:0001913)1.79187081
179Retrobulbar optic neuritis (HP:0100654)1.77606953
180Optic neuritis (HP:0100653)1.77606953
181Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76648589
182Hyperglycinemia (HP:0002154)1.74882965
183Sandal gap (HP:0001852)1.74362999
184Missing ribs (HP:0000921)1.74226766
185Constricted visual fields (HP:0001133)1.73965105
186Increased serum lactate (HP:0002151)1.73158823
187Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73058447
188Aplasia/Hypoplasia of the spleen (HP:0010451)1.72899127
189Recurrent bronchitis (HP:0002837)1.71049612
190Asplenia (HP:0001746)1.70975028
191Exertional dyspnea (HP:0002875)1.69698996
192Abnormality of male internal genitalia (HP:0000022)1.69500279
193Cystic liver disease (HP:0006706)1.66426660
194Recurrent cutaneous fungal infections (HP:0011370)1.65860776
195Chronic mucocutaneous candidiasis (HP:0002728)1.65860776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.52509263
2CDC73.98738616
3TAOK33.62354163
4BUB13.52758724
5NEK23.40138897
6FRK3.17587755
7BRSK23.09284993
8SRPK13.02794418
9TEC2.96502400
10STK38L2.94398008
11TTK2.93724607
12MAP4K22.83433261
13ACVR1B2.78156854
14PLK42.77424321
15TXK2.70499664
16LATS22.55216377
17CDK122.49822689
18PLK12.46987764
19PDK42.45196844
20PDK32.45196844
21BMPR1B2.33484004
22EIF2AK12.33397409
23LATS12.13053313
24DYRK32.08566744
25ITK2.06268616
26CHEK22.03116220
27PLK32.00758205
28MAP4K11.99135274
29TIE11.94894645
30ADRBK21.82178525
31NEK11.80953837
32KIT1.76996920
33AURKB1.76932184
34GRK11.76088670
35SYK1.75777589
36RIPK41.75506204
37BTK1.73879339
38STK31.70292961
39PDK21.66126332
40BMPR21.65973534
41BRSK11.65616164
42MST41.63882765
43CDK71.62748759
44IKBKE1.56048821
45CHEK11.54731785
46IKBKB1.52478587
47MKNK21.51194013
48MATK1.50804564
49ATR1.42864353
50PNCK1.42770556
51VRK11.37544877
52WNK41.32045289
53MAP3K141.30025776
54EIF2AK31.26367014
55PIK3CG1.24746603
56TNIK1.23157974
57EPHA21.20311559
58FES1.19980058
59IRAK11.16637826
60CCNB11.15994746
61PIK3CA1.15346915
62ATM1.14688222
63AURKA1.13987786
64CDK41.13750648
65TBK11.12740868
66MELK1.11533501
67MKNK11.11502895
68LYN1.11461457
69CDK191.10752295
70JAK31.07238590
71IRAK41.05407198
72AKT31.04782078
73GRK61.02800411
74TSSK61.02646080
75PRKCQ0.99446878
76TESK20.98115116
77TRPM70.97410470
78BCKDK0.94767329
79CDK20.94363641
80NLK0.90183216
81MARK30.89826091
82LCK0.89008835
83CSF1R0.87240845
84BRD40.86488250
85FLT30.84193223
86EIF2AK20.82329320
87MAP3K80.82164222
88DYRK20.81482826
89IRAK30.80635255
90OXSR10.79187226
91NME20.79110628
92STK390.78969038
93CDK10.78888134
94RPS6KA40.78391643
95STK40.77403363
96MAP3K60.76385425
97TNK20.76353320
98TLK10.75571462
99MAP2K20.75068279
100TRIM280.74311669
101BRAF0.73832626
102PASK0.73088088
103ZAK0.72827078
104ERBB30.70821359
105CAMKK20.69818674
106ERBB40.68714019
107CDK30.68704595
108STK380.68480573
109NEK60.67990457
110TGFBR10.67022394
111MAPK130.66869824
112STK160.66648052
113INSRR0.66371944
114HCK0.65160804
115GRK70.64812159
116PRKCI0.64462881
117PBK0.62298653
118RPS6KB20.59311636
119ALK0.59202147
120VRK20.59097109
121STK240.58388307
122BLK0.58082850
123MAPKAPK30.57163728
124ABL10.56240767
125CSNK2A10.53943723
126CSNK2A20.53030751
127MAP2K60.52082505
128CDK60.51555938
129PIM10.51490718
130PAK10.51186597
131CSNK1E0.49033760
132ZAP700.48016448
133STK100.47898063
134SCYL20.46750019
135TYK20.45901243
136NME10.44066986
137CHUK0.43454058
138PINK10.41336109
139IGF1R0.39800755
140MAPKAPK50.39298502
141OBSCN0.39002596
142CDK90.37107579
143MAPK100.37091798
144TESK10.36840848
145CDK80.36721548
146MTOR0.36449970
147KDR0.36292849
148CSK0.36055344
149MAPK150.33931699
150PRKAA10.33632869
151WNK30.32415823
152MAPK110.31726502
153CSNK1D0.31628625
154PRKDC0.31599170
155MAPK140.30175067
156GSK3B0.29435976
157NUAK10.27906054
158ABL20.25309302
159TYRO30.23156123
160RPS6KA50.22431344
161RAF10.22322278
162CSNK1G10.21137505
163AKT20.20606470
164MUSK0.19416297
165PRKD30.18636705
166PAK40.17413740
167AKT10.16777867
168DYRK1A0.16615549
169MAPK10.15759031

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.75826939
2RNA polymerase_Homo sapiens_hsa030204.34866357
3RNA transport_Homo sapiens_hsa030133.71654704
4DNA replication_Homo sapiens_hsa030303.66901149
5Mismatch repair_Homo sapiens_hsa034303.57172284
6Homologous recombination_Homo sapiens_hsa034403.49329389
7Basal transcription factors_Homo sapiens_hsa030223.48681159
8Asthma_Homo sapiens_hsa053103.43467998
9Fanconi anemia pathway_Homo sapiens_hsa034603.41871842
10Vitamin B6 metabolism_Homo sapiens_hsa007503.40490324
11Cell cycle_Homo sapiens_hsa041103.39462984
12Intestinal immune network for IgA production_Homo sapiens_hsa046723.17741223
13Primary immunodeficiency_Homo sapiens_hsa053403.16168635
14Spliceosome_Homo sapiens_hsa030403.03810634
15Allograft rejection_Homo sapiens_hsa053302.86539345
16Graft-versus-host disease_Homo sapiens_hsa053322.68837608
17Autoimmune thyroid disease_Homo sapiens_hsa053202.67792004
18Nucleotide excision repair_Homo sapiens_hsa034202.64489418
19Pyrimidine metabolism_Homo sapiens_hsa002402.45141242
20mRNA surveillance pathway_Homo sapiens_hsa030152.30940087
21Type I diabetes mellitus_Homo sapiens_hsa049402.24098349
22RNA degradation_Homo sapiens_hsa030182.14010603
23One carbon pool by folate_Homo sapiens_hsa006702.13098020
24Base excision repair_Homo sapiens_hsa034102.08550185
25Proteasome_Homo sapiens_hsa030502.08356973
26p53 signaling pathway_Homo sapiens_hsa041152.00209127
27Oxidative phosphorylation_Homo sapiens_hsa001901.98045300
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84330803
29Nitrogen metabolism_Homo sapiens_hsa009101.83596892
30Non-homologous end-joining_Homo sapiens_hsa034501.81644450
31Oocyte meiosis_Homo sapiens_hsa041141.74640882
32Caffeine metabolism_Homo sapiens_hsa002321.69911206
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66754503
34Parkinsons disease_Homo sapiens_hsa050121.66114370
35Ribosome_Homo sapiens_hsa030101.62486081
36Staphylococcus aureus infection_Homo sapiens_hsa051501.62258438
37Protein export_Homo sapiens_hsa030601.61005155
38Purine metabolism_Homo sapiens_hsa002301.58251159
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49987810
40Hematopoietic cell lineage_Homo sapiens_hsa046401.47392412
41Phototransduction_Homo sapiens_hsa047441.42162473
42Rheumatoid arthritis_Homo sapiens_hsa053231.36753009
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35069267
44Butanoate metabolism_Homo sapiens_hsa006501.29226989
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25900844
46Chemical carcinogenesis_Homo sapiens_hsa052041.24605138
47Leishmaniasis_Homo sapiens_hsa051401.22698374
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.22329307
49Epstein-Barr virus infection_Homo sapiens_hsa051691.21374741
50Peroxisome_Homo sapiens_hsa041461.21068321
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.17246202
52Pentose phosphate pathway_Homo sapiens_hsa000301.14614640
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12816407
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10537963
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10324231
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07262300
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07133020
58Propanoate metabolism_Homo sapiens_hsa006401.05416901
59Tryptophan metabolism_Homo sapiens_hsa003801.02938158
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.02055440
61Retinol metabolism_Homo sapiens_hsa008301.01805426
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00108520
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99419065
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96728875
65Selenocompound metabolism_Homo sapiens_hsa004500.96424037
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.96334220
67Olfactory transduction_Homo sapiens_hsa047400.95276661
68TGF-beta signaling pathway_Homo sapiens_hsa043500.95078937
69Biosynthesis of amino acids_Homo sapiens_hsa012300.91740320
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90770613
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.90008382
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88765772
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88278975
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85210080
75Herpes simplex infection_Homo sapiens_hsa051680.82081661
76MicroRNAs in cancer_Homo sapiens_hsa052060.81262748
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79864979
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79085300
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78298690
80Viral carcinogenesis_Homo sapiens_hsa052030.77417417
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.75839701
82Alzheimers disease_Homo sapiens_hsa050100.75234957
83Viral myocarditis_Homo sapiens_hsa054160.73024096
84Systemic lupus erythematosus_Homo sapiens_hsa053220.69918822
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69272749
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68779741
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65087138
88Hippo signaling pathway_Homo sapiens_hsa043900.64588118
89Folate biosynthesis_Homo sapiens_hsa007900.61167185
90Legionellosis_Homo sapiens_hsa051340.58978685
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58612834
92Linoleic acid metabolism_Homo sapiens_hsa005910.57984632
93HTLV-I infection_Homo sapiens_hsa051660.57385982
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57360517
95T cell receptor signaling pathway_Homo sapiens_hsa046600.56247883
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.53855368
97Huntingtons disease_Homo sapiens_hsa050160.53756531
98Basal cell carcinoma_Homo sapiens_hsa052170.53533192
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52629214
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.51837793
101Glutathione metabolism_Homo sapiens_hsa004800.51579085
102Antigen processing and presentation_Homo sapiens_hsa046120.50620543
103Small cell lung cancer_Homo sapiens_hsa052220.50577605
104Thyroid cancer_Homo sapiens_hsa052160.50212986
105Measles_Homo sapiens_hsa051620.47013683
106Sulfur metabolism_Homo sapiens_hsa009200.46484301
107Taste transduction_Homo sapiens_hsa047420.45084808
108B cell receptor signaling pathway_Homo sapiens_hsa046620.44679441
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43833966
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43107721
111Fat digestion and absorption_Homo sapiens_hsa049750.43002192
112ABC transporters_Homo sapiens_hsa020100.40834738
113Hedgehog signaling pathway_Homo sapiens_hsa043400.40007218
114Tuberculosis_Homo sapiens_hsa051520.39124183
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37175499
116Collecting duct acid secretion_Homo sapiens_hsa049660.36283284
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.35421276
118Arachidonic acid metabolism_Homo sapiens_hsa005900.33802999
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31033891
120Vitamin digestion and absorption_Homo sapiens_hsa049770.30584595
121Regulation of autophagy_Homo sapiens_hsa041400.29248950
122Adherens junction_Homo sapiens_hsa045200.28312956
123FoxO signaling pathway_Homo sapiens_hsa040680.27224704
124Tight junction_Homo sapiens_hsa045300.25861341
125Carbon metabolism_Homo sapiens_hsa012000.25797795
126Lysine degradation_Homo sapiens_hsa003100.24305192
127Arginine and proline metabolism_Homo sapiens_hsa003300.23743993
128mTOR signaling pathway_Homo sapiens_hsa041500.23466109
129Dorso-ventral axis formation_Homo sapiens_hsa043200.23371243
130Pathways in cancer_Homo sapiens_hsa052000.23335770
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22379065
132Wnt signaling pathway_Homo sapiens_hsa043100.21975306
133Metabolic pathways_Homo sapiens_hsa011000.20263666
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19027804
135Circadian rhythm_Homo sapiens_hsa047100.17961439
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17897054
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17851006
138Colorectal cancer_Homo sapiens_hsa052100.17176463
139Prostate cancer_Homo sapiens_hsa052150.17003589
140Influenza A_Homo sapiens_hsa051640.16807288
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16501521
142Ether lipid metabolism_Homo sapiens_hsa005650.15899124
143Sulfur relay system_Homo sapiens_hsa041220.15861723
144Fructose and mannose metabolism_Homo sapiens_hsa000510.15768764
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13704556
146Notch signaling pathway_Homo sapiens_hsa043300.13219860
147Glucagon signaling pathway_Homo sapiens_hsa049220.11367839
148Melanoma_Homo sapiens_hsa052180.11138369
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08999188
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08995329
151Inositol phosphate metabolism_Homo sapiens_hsa005620.07266234
152HIF-1 signaling pathway_Homo sapiens_hsa040660.07187917
153Alcoholism_Homo sapiens_hsa050340.06579140
154Sphingolipid metabolism_Homo sapiens_hsa006000.04636068
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03871699
156Bladder cancer_Homo sapiens_hsa052190.03129080
157Hepatitis B_Homo sapiens_hsa051610.02025979
158NOD-like receptor signaling pathway_Homo sapiens_hsa046210.01401693
159Mineral absorption_Homo sapiens_hsa049780.01057435
160Renal cell carcinoma_Homo sapiens_hsa052110.00948574

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