ATG10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.93807653
2behavioral response to nicotine (GO:0035095)4.21669510
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.19487983
4signal peptide processing (GO:0006465)4.09789688
5viral transcription (GO:0019083)4.09464017
6translational termination (GO:0006415)4.00765150
7ribosomal small subunit assembly (GO:0000028)3.84920538
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.79730063
9daunorubicin metabolic process (GO:0044597)3.76914929
10polyketide metabolic process (GO:0030638)3.76914929
11doxorubicin metabolic process (GO:0044598)3.76914929
12neutrophil activation involved in immune response (GO:0002283)3.73172282
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65818283
14cotranslational protein targeting to membrane (GO:0006613)3.64796115
15water-soluble vitamin biosynthetic process (GO:0042364)3.63767424
16response to peptidoglycan (GO:0032494)3.62789780
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62108307
18eosinophil chemotaxis (GO:0048245)3.60170618
19protein targeting to ER (GO:0045047)3.58525738
20proteasome assembly (GO:0043248)3.57458127
21cytochrome complex assembly (GO:0017004)3.49025228
22protein-cofactor linkage (GO:0018065)3.47978717
23translational elongation (GO:0006414)3.45624255
24inositol phosphate catabolic process (GO:0071545)3.45195936
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40219053
26protein localization to endoplasmic reticulum (GO:0070972)3.38716823
27chaperone-mediated protein transport (GO:0072321)3.36288325
28protein complex biogenesis (GO:0070271)3.34215454
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31715582
30eosinophil migration (GO:0072677)3.29764562
31inositol phosphate dephosphorylation (GO:0046855)3.28767247
32phosphorylated carbohydrate dephosphorylation (GO:0046838)3.28767247
33regulation of metalloenzyme activity (GO:0048552)3.26817837
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24477341
35phagosome maturation (GO:0090382)3.22268050
36histamine transport (GO:0051608)3.19865006
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19786130
38histamine secretion (GO:0001821)3.17709701
39presynaptic membrane assembly (GO:0097105)3.17056329
40response to pheromone (GO:0019236)3.14894554
41ATP biosynthetic process (GO:0006754)3.12357850
42superoxide anion generation (GO:0042554)3.11335012
43respiratory burst (GO:0045730)3.09811276
44ribosomal small subunit biogenesis (GO:0042274)3.08988967
45regulation of oxidative phosphorylation (GO:0002082)3.07913447
46hydrogen ion transmembrane transport (GO:1902600)3.07512277
47dopamine transport (GO:0015872)3.07190360
48protein localization to cilium (GO:0061512)3.05531324
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05129246
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05129246
51regulation of mast cell activation (GO:0033003)3.03695191
52preassembly of GPI anchor in ER membrane (GO:0016254)3.03599822
53maturation of 5.8S rRNA (GO:0000460)3.03594595
54maturation of SSU-rRNA (GO:0030490)3.03433212
55purinergic nucleotide receptor signaling pathway (GO:0035590)3.02914535
56termination of RNA polymerase III transcription (GO:0006386)3.01559885
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.01559885
58respiratory chain complex IV assembly (GO:0008535)2.99668681
59pseudouridine synthesis (GO:0001522)2.99563965
60cellular protein complex disassembly (GO:0043624)2.96405262
61intracellular protein transmembrane import (GO:0044743)2.95389176
62rRNA modification (GO:0000154)2.93792513
63negative regulation of dendrite morphogenesis (GO:0050774)2.92698532
64L-fucose catabolic process (GO:0042355)2.92688351
65fucose catabolic process (GO:0019317)2.92688351
66L-fucose metabolic process (GO:0042354)2.92688351
67proton transport (GO:0015992)2.92660603
68tryptophan catabolic process (GO:0006569)2.91209594
69indole-containing compound catabolic process (GO:0042436)2.91209594
70indolalkylamine catabolic process (GO:0046218)2.91209594
71purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89429950
72toxin transport (GO:1901998)2.88697096
73viral life cycle (GO:0019058)2.88142296
74mannosylation (GO:0097502)2.87894946
75respiratory electron transport chain (GO:0022904)2.87687085
76hydrogen transport (GO:0006818)2.87640615
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87484253
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84454936
79translational initiation (GO:0006413)2.83808281
80replication fork processing (GO:0031297)2.83630144
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82814220
82translation (GO:0006412)2.81831070
83regulation of mast cell activation involved in immune response (GO:0033006)2.81627997
84cellular ketone body metabolic process (GO:0046950)2.80828922
85norepinephrine metabolic process (GO:0042415)2.80768236
86viral protein processing (GO:0019082)2.80576110
87electron transport chain (GO:0022900)2.80318880
88negative regulation of mast cell activation (GO:0033004)2.80163717
89nucleotide transmembrane transport (GO:1901679)2.79393038
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79324367
91ribosomal large subunit biogenesis (GO:0042273)2.79087923
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79000889
93glycoside metabolic process (GO:0016137)2.78541982
94indolalkylamine metabolic process (GO:0006586)2.77507770
95prostate gland growth (GO:0060736)2.76354388
96axoneme assembly (GO:0035082)2.75782499
97negative regulation of phagocytosis (GO:0050765)2.74810764
98positive regulation of mitochondrial fission (GO:0090141)2.74006453
99regulation of mast cell degranulation (GO:0043304)2.73111439
100positive regulation of prostaglandin secretion (GO:0032308)2.71886098
101mitochondrial respiratory chain complex assembly (GO:0033108)2.71453406
102positive regulation of antigen processing and presentation (GO:0002579)2.69943968
103regulation of antigen processing and presentation (GO:0002577)2.69850407
104presynaptic membrane organization (GO:0097090)2.68722972
105anterograde synaptic vesicle transport (GO:0048490)2.65635502
106male meiosis I (GO:0007141)2.65598951
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.65141759
108NADH dehydrogenase complex assembly (GO:0010257)2.65141759
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65141759
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.63314348
111tRNA processing (GO:0008033)2.61445235
112protein K6-linked ubiquitination (GO:0085020)2.60293970
113regulation of T-helper 1 cell differentiation (GO:0045625)2.59749918
114nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59676853
115kidney morphogenesis (GO:0060993)2.58747558
116negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.58746143
117ketone body metabolic process (GO:1902224)2.58731880
118positive regulation of lymphocyte migration (GO:2000403)2.58242496
119negative regulation of telomere maintenance (GO:0032205)2.58219312
120epithelial cilium movement (GO:0003351)2.57215175
121defense response to protozoan (GO:0042832)2.56576721
122regulation of type B pancreatic cell apoptotic process (GO:2000674)2.56447201
123intracellular pH reduction (GO:0051452)2.56261165
124recombinational repair (GO:0000725)2.55977682
125positive regulation of mast cell degranulation (GO:0043306)2.55542676
126positive regulation of mast cell activation involved in immune response (GO:0033008)2.55542676
127double-strand break repair via homologous recombination (GO:0000724)2.54530753
128organelle disassembly (GO:1903008)2.54156792
129nonmotile primary cilium assembly (GO:0035058)2.54075874
130GPI anchor metabolic process (GO:0006505)2.53921144
131adaptation of signaling pathway (GO:0023058)2.53721493
132rRNA methylation (GO:0031167)2.53720846
133ubiquinone biosynthetic process (GO:0006744)2.52943255
134sulfation (GO:0051923)2.52940736
135piRNA metabolic process (GO:0034587)2.52790628
136regulation of chemokine biosynthetic process (GO:0045073)2.51671600
137tryptophan metabolic process (GO:0006568)2.51391215
138cellular component biogenesis (GO:0044085)2.51145359
139centriole replication (GO:0007099)2.51041061
140reactive oxygen species biosynthetic process (GO:1903409)2.50963486
141kynurenine metabolic process (GO:0070189)2.50821531
142microglial cell activation (GO:0001774)2.50287756
143heart process (GO:0003015)2.48300352
144heart contraction (GO:0060047)2.48300352
145cytidine metabolic process (GO:0046087)2.47822721
146cytidine catabolic process (GO:0006216)2.47822721
147cytidine deamination (GO:0009972)2.47822721
148dentate gyrus development (GO:0021542)2.46206924
149ATP synthesis coupled proton transport (GO:0015986)2.45470660
150energy coupled proton transport, down electrochemical gradient (GO:0015985)2.45470660
151positive regulation of T cell migration (GO:2000406)2.44987516
152transferrin transport (GO:0033572)2.44932732
153regulation of neuron projection regeneration (GO:0070570)2.44736034
154regulation of axon regeneration (GO:0048679)2.44736034
155nucleoside diphosphate catabolic process (GO:0009134)2.42941270
156protein neddylation (GO:0045116)2.42363697
157hydrogen peroxide biosynthetic process (GO:0050665)2.41469096
158dendritic cell migration (GO:0036336)2.40283639
159response to interferon-beta (GO:0035456)2.39776773
160regulation of activation of Janus kinase activity (GO:0010533)2.38902504
161dendritic cell chemotaxis (GO:0002407)2.38677004
162cellular response to interferon-beta (GO:0035458)2.37454973
163energy homeostasis (GO:0097009)2.37101307
164pH reduction (GO:0045851)2.35378304
165positive regulation of chemokine biosynthetic process (GO:0045080)2.33995165
166mast cell activation (GO:0045576)2.33878981
167fucose metabolic process (GO:0006004)2.33556119
168aminoglycoside antibiotic metabolic process (GO:0030647)2.33487336
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.33369035
170regulation of mitochondrial translation (GO:0070129)2.32561674
171G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.32502442
172platelet dense granule organization (GO:0060155)2.31913002
173neutrophil activation (GO:0042119)2.31769238
174positive regulation of cAMP-mediated signaling (GO:0043950)2.31584736
175interferon-gamma production (GO:0032609)2.31320488
176protein maturation by protein folding (GO:0022417)2.30158316
177peptidyl-histidine modification (GO:0018202)2.29889255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.86285680
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.55287018
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54883498
4ZNF274_21170338_ChIP-Seq_K562_Hela3.32956045
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29277911
6GBX2_23144817_ChIP-Seq_PC3_Human3.18531018
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.14096386
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.96408378
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70723352
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60484127
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60054066
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56956811
13IGF1R_20145208_ChIP-Seq_DFB_Human2.54926092
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54071650
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51442464
16TAF15_26573619_Chip-Seq_HEK293_Human2.43988126
17VDR_22108803_ChIP-Seq_LS180_Human2.23113833
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21592845
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15382543
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.11759448
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09861302
22VDR_23849224_ChIP-Seq_CD4+_Human1.99619854
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96963801
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.89473604
25MYC_18940864_ChIP-ChIP_HL60_Human1.85167611
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81201695
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80793858
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80776400
29P300_19829295_ChIP-Seq_ESCs_Human1.78774795
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75939552
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74928470
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71345627
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68735718
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66380294
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65586401
36TP53_22573176_ChIP-Seq_HFKS_Human1.64859813
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62625796
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.61395674
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.56389879
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56115591
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55491421
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.54036116
43* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53259711
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51924178
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.51858431
46IRF1_19129219_ChIP-ChIP_H3396_Human1.50715254
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49341015
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47963409
49P53_22387025_ChIP-Seq_ESCs_Mouse1.47658776
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47095751
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.47095751
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.46750463
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.46364352
54FOXP3_21729870_ChIP-Seq_TREG_Human1.45632310
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.44682811
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42017760
57EZH2_22144423_ChIP-Seq_EOC_Human1.39585370
58BCAT_22108803_ChIP-Seq_LS180_Human1.38567245
59NMYC_18555785_Chip-Seq_ESCs_Mouse1.38530029
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38528313
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.37671520
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36216417
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.35450251
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35165163
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34759539
66ER_23166858_ChIP-Seq_MCF-7_Human1.34575790
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34544169
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33357197
69* SMAD4_21799915_ChIP-Seq_A2780_Human1.33141884
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31677990
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31383607
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30901452
73CBP_20019798_ChIP-Seq_JUKART_Human1.30901452
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30891569
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30657331
76P300_18555785_Chip-Seq_ESCs_Mouse1.29981911
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.29970543
78FUS_26573619_Chip-Seq_HEK293_Human1.29787735
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29374540
80AR_20517297_ChIP-Seq_VCAP_Human1.28657901
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.27534607
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25424631
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24332040
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22455915
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22455915
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.21996511
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21951005
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21263856
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20930059
90NCOR_22424771_ChIP-Seq_293T_Human1.20475041
91* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19792478
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.19744451
93SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19710686
94PU1_27457419_Chip-Seq_LIVER_Mouse1.18840283
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18655195
96E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17893484
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17549293
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.16557670
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16399164
100ZFX_18555785_Chip-Seq_ESCs_Mouse1.15961062
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15791372
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.15565211
103CTCF_18555785_Chip-Seq_ESCs_Mouse1.15439701
104ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14197770
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.13296385
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12840577
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12818165
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.12728713
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11746236
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11731503
111* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10950856
112EWS_26573619_Chip-Seq_HEK293_Human1.10725844
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10000401
114AR_25329375_ChIP-Seq_VCAP_Human1.09445634
115TCF4_22108803_ChIP-Seq_LS180_Human1.08858183
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.08400381
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08350814
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08069185
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07392290
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07182624
121STAT4_19710469_ChIP-ChIP_TH1__Mouse1.06935607
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.06646241
123* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05292546
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.05025729
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05007830
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04449722
127JUN_21703547_ChIP-Seq_K562_Human1.04181089
128* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04108413
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03363430
130EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02314049
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02133225
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00921990
133NANOG_19829295_ChIP-Seq_ESCs_Human1.00281617
134SOX2_19829295_ChIP-Seq_ESCs_Human1.00281617
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99156921
136ELK1_19687146_ChIP-ChIP_HELA_Human0.99051522
137SMAD3_21741376_ChIP-Seq_EPCs_Human0.97577441
138* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97376919
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97187545
140FOXH1_21741376_ChIP-Seq_EPCs_Human0.97004443
141* HOXB7_26014856_ChIP-Seq_BT474_Human0.96895894
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96632625
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96632625
144OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95649193
145SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95493958
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95253069
147RNF2_27304074_Chip-Seq_NSC_Mouse0.95179309
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94477855
149TCF4_23295773_ChIP-Seq_U87_Human0.93947300
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.92693607
151ERG_20517297_ChIP-Seq_VCAP_Human0.92225524
152HTT_18923047_ChIP-ChIP_STHdh_Human0.91325651
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91037933
154STAT3_23295773_ChIP-Seq_U87_Human0.90681202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.53241720
2MP0009697_abnormal_copulation3.33580366
3MP0002102_abnormal_ear_morphology3.13480517
4MP0003183_abnormal_peptide_metabolism2.91209616
5MP0010386_abnormal_urinary_bladder2.80019914
6MP0000372_irregular_coat_pigmentation2.80001702
7MP0005171_absent_coat_pigmentation2.79189313
8MP0001986_abnormal_taste_sensitivity2.76985359
9MP0002148_abnormal_hypersensitivity_rea2.73162233
10MP0002876_abnormal_thyroid_physiology2.71787220
11MP0003724_increased_susceptibility_to2.64064551
12MP0009379_abnormal_foot_pigmentation2.63860892
13MP0009785_altered_susceptibility_to2.55772963
14MP0008877_abnormal_DNA_methylation2.40808307
15MP0006072_abnormal_retinal_apoptosis2.38489295
16MP0005379_endocrine/exocrine_gland_phen2.29314874
17MP0005646_abnormal_pituitary_gland2.20222405
18MP0005671_abnormal_response_to2.17818994
19MP0001188_hyperpigmentation2.17513693
20MP0003806_abnormal_nucleotide_metabolis2.17257345
21MP0002735_abnormal_chemical_nociception2.16275604
22MP0006276_abnormal_autonomic_nervous2.13306434
23MP0005551_abnormal_eye_electrophysiolog2.11948357
24MP0005310_abnormal_salivary_gland2.08360073
25MP0006082_CNS_inflammation2.05143957
26MP0002938_white_spotting1.95119670
27MP0002163_abnormal_gland_morphology1.92709672
28MP0002638_abnormal_pupillary_reflex1.91101998
29MP0002419_abnormal_innate_immunity1.89279085
30MP0006292_abnormal_olfactory_placode1.89275002
31MP0003880_abnormal_central_pattern1.88805605
32MP0003718_maternal_effect1.86717002
33MP0001905_abnormal_dopamine_level1.85490980
34MP0003011_delayed_dark_adaptation1.79662300
35MP0005000_abnormal_immune_tolerance1.79352166
36MP0008872_abnormal_physiological_respon1.76947906
37MP0005645_abnormal_hypothalamus_physiol1.76203810
38MP0003195_calcinosis1.74022526
39MP0002837_dystrophic_cardiac_calcinosis1.73655793
40MP0000569_abnormal_digit_pigmentation1.73141681
41MP0002736_abnormal_nociception_after1.72209093
42MP0005025_abnormal_response_to1.71179123
43MP0000681_abnormal_thyroid_gland1.70482194
44MP0005253_abnormal_eye_physiology1.70386078
45MP0005387_immune_system_phenotype1.68773534
46MP0001790_abnormal_immune_system1.68773534
47MP0001984_abnormal_olfaction1.66049543
48MP0005409_darkened_coat_color1.65969324
49MP0008875_abnormal_xenobiotic_pharmacok1.65108096
50MP0001485_abnormal_pinna_reflex1.62007792
51MP0004147_increased_porphyrin_level1.59507026
52MP0004885_abnormal_endolymph1.57516400
53MP0001968_abnormal_touch/_nociception1.55841747
54MP0008058_abnormal_DNA_repair1.52282029
55MP0001501_abnormal_sleep_pattern1.49422661
56MP0000631_abnormal_neuroendocrine_gland1.48930954
57MP0002693_abnormal_pancreas_physiology1.48222626
58MP0003436_decreased_susceptibility_to1.47894572
59MP0004145_abnormal_muscle_electrophysio1.47161338
60MP0000685_abnormal_immune_system1.43743789
61MP0002723_abnormal_immune_serum1.43510057
62MP0002132_abnormal_respiratory_system1.42208836
63MP0003646_muscle_fatigue1.41823377
64MP0002452_abnormal_antigen_presenting1.41725414
65MP0002653_abnormal_ependyma_morphology1.39332483
66MP0002234_abnormal_pharynx_morphology1.35068957
67MP0002277_abnormal_respiratory_mucosa1.34693871
68MP0009046_muscle_twitch1.32620693
69MP0005377_hearing/vestibular/ear_phenot1.32617222
70MP0003878_abnormal_ear_physiology1.32617222
71MP0001819_abnormal_immune_cell1.31417011
72MP0002420_abnormal_adaptive_immunity1.30754702
73MP0005075_abnormal_melanosome_morpholog1.29785375
74MP0001800_abnormal_humoral_immune1.29114295
75MP0003283_abnormal_digestive_organ1.28880830
76MP0004133_heterotaxia1.27742114
77MP0008995_early_reproductive_senescence1.26858203
78MP0001293_anophthalmia1.23536307
79MP0003186_abnormal_redox_activity1.20714171
80MP0004782_abnormal_surfactant_physiolog1.20496480
81MP0002160_abnormal_reproductive_system1.20422700
82MP0008789_abnormal_olfactory_epithelium1.18598208
83MP0000427_abnormal_hair_cycle1.17556100
84MP0005389_reproductive_system_phenotype1.16675329
85MP0008260_abnormal_autophagy1.09458546
86MP0005464_abnormal_platelet_physiology1.08720924
87MP0000015_abnormal_ear_pigmentation1.07526705
88MP0005535_abnormal_body_temperature1.07160601
89MP0004510_myositis1.06454298
90MP0000678_abnormal_parathyroid_gland1.06218723
91MP0003252_abnormal_bile_duct1.06027816
92MP0001502_abnormal_circadian_rhythm1.04929139
93MP0001845_abnormal_inflammatory_respons1.02468723
94MP0002734_abnormal_mechanical_nocicepti1.01648781
95MP0005084_abnormal_gallbladder_morpholo1.01002724
96MP0004215_abnormal_myocardial_fiber1.00128224
97MP0002928_abnormal_bile_duct0.99995335
98MP0002733_abnormal_thermal_nociception0.99122659
99MP0000538_abnormal_urinary_bladder0.97440176
100MP0009745_abnormal_behavioral_response0.96629157
101MP0001970_abnormal_pain_threshold0.95650373
102MP0001486_abnormal_startle_reflex0.94284687
103MP0004742_abnormal_vestibular_system0.93843650
104MP0002006_tumorigenesis0.92574115
105MP0003786_premature_aging0.92528540
106MP0002272_abnormal_nervous_system0.92319201
107MP0001919_abnormal_reproductive_system0.91574299
108MP0008469_abnormal_protein_level0.91508342
109MP0001764_abnormal_homeostasis0.90880788
110MP0009764_decreased_sensitivity_to0.90151471
111MP0005085_abnormal_gallbladder_physiolo0.89379687
112MP0005360_urolithiasis0.88969673
113MP0005195_abnormal_posterior_eye0.87968300
114MP0001929_abnormal_gametogenesis0.87553233
115MP0005058_abnormal_lysosome_morphology0.87104791
116MP0002822_catalepsy0.86036828
117MP0001186_pigmentation_phenotype0.84451863
118MP0006036_abnormal_mitochondrial_physio0.83792566
119MP0000230_abnormal_systemic_arterial0.82294136
120MP0002210_abnormal_sex_determination0.81622306
121MP0002064_seizures0.80216848
122MP0005410_abnormal_fertilization0.80168970
123MP0001346_abnormal_lacrimal_gland0.79852842
124MP0000026_abnormal_inner_ear0.79486225
125MP0000716_abnormal_immune_system0.79199546
126MP0004043_abnormal_pH_regulation0.78980757
127MP0002933_joint_inflammation0.78527893
128MP0003763_abnormal_thymus_physiology0.78174979
129MP0005332_abnormal_amino_acid0.76753417
130MP0001851_eye_inflammation0.76201127
131MP0002572_abnormal_emotion/affect_behav0.76035327
132MP0002557_abnormal_social/conspecific_i0.75466926
133MP0001533_abnormal_skeleton_physiology0.75355114
134MP0000653_abnormal_sex_gland0.74855565
135MP0001529_abnormal_vocalization0.73778045
136MP0003698_abnormal_male_reproductive0.73053316
137MP0002282_abnormal_trachea_morphology0.72691590
138MP0005174_abnormal_tail_pigmentation0.72641630
139MP0005391_vision/eye_phenotype0.72368053
140MP0002909_abnormal_adrenal_gland0.71987228
141MP0002752_abnormal_somatic_nervous0.71432089
142MP0003172_abnormal_lysosome_physiology0.70413841
143MP0002405_respiratory_system_inflammati0.69378943
144MP0002138_abnormal_hepatobiliary_system0.67837627
145MP0003136_yellow_coat_color0.67626564
146MP0008004_abnormal_stomach_pH0.67209924
147MP0004142_abnormal_muscle_tone0.66678324
148MP0002067_abnormal_sensory_capabilities0.65803893
149MP0002078_abnormal_glucose_homeostasis0.64398298
150MP0003191_abnormal_cellular_cholesterol0.64381659
151MP0002095_abnormal_skin_pigmentation0.64031553
152MP0003787_abnormal_imprinting0.62896115
153MP0003122_maternal_imprinting0.62741863
154MP0002166_altered_tumor_susceptibility0.61162899
155MP0002751_abnormal_autonomic_nervous0.60089993
156MP0000371_diluted_coat_color0.59196035

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.81600431
2Acute necrotizing encephalopathy (HP:0006965)4.23575543
3Progressive macrocephaly (HP:0004481)4.08793288
4Pancreatic cysts (HP:0001737)4.04085274
5Abnormal mitochondria in muscle tissue (HP:0008316)3.93937824
6Mitochondrial inheritance (HP:0001427)3.74177763
7Abnormality of midbrain morphology (HP:0002418)3.67496794
8Molar tooth sign on MRI (HP:0002419)3.67496794
9Congenital stationary night blindness (HP:0007642)3.50286413
10Type I transferrin isoform profile (HP:0003642)3.34547526
11Recurrent abscess formation (HP:0002722)3.29762650
12Nephronophthisis (HP:0000090)3.27240121
13Acute encephalopathy (HP:0006846)3.23112566
14Increased CSF lactate (HP:0002490)3.19360977
15Hepatic necrosis (HP:0002605)3.14505859
16Hepatocellular necrosis (HP:0001404)3.09753302
17Methylmalonic acidemia (HP:0002912)3.07062900
18Abnormal number of erythroid precursors (HP:0012131)3.04375207
19Recurrent bacterial skin infections (HP:0005406)3.00385629
20Increased IgM level (HP:0003496)2.95223371
21Congenital, generalized hypertrichosis (HP:0004540)2.94099467
22Eczematoid dermatitis (HP:0000976)2.90665721
23Abnormality of the renal cortex (HP:0011035)2.88086858
24Retrobulbar optic neuritis (HP:0100654)2.85113506
25Optic neuritis (HP:0100653)2.85113506
26Abnormality of cells of the erythroid lineage (HP:0012130)2.75513417
27Abnormality of the renal medulla (HP:0100957)2.74836981
28Renal Fanconi syndrome (HP:0001994)2.73053235
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69433364
30Abnormal protein N-linked glycosylation (HP:0012347)2.69433364
31Abnormal protein glycosylation (HP:0012346)2.69433364
32Abnormal glycosylation (HP:0012345)2.69433364
33Increased hepatocellular lipid droplets (HP:0006565)2.68657563
34Methylmalonic aciduria (HP:0012120)2.60741339
353-Methylglutaconic aciduria (HP:0003535)2.58349975
36Generalized aminoaciduria (HP:0002909)2.58014963
37Abolished electroretinogram (ERG) (HP:0000550)2.53495968
38Neuroendocrine neoplasm (HP:0100634)2.53475304
39Myositis (HP:0100614)2.53204665
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52812835
41Abnormality of alanine metabolism (HP:0010916)2.52812835
42Hyperalaninemia (HP:0003348)2.52812835
43Abnormal rod and cone electroretinograms (HP:0008323)2.45123363
44Attenuation of retinal blood vessels (HP:0007843)2.38913992
45Elevated erythrocyte sedimentation rate (HP:0003565)2.38733534
46Orchitis (HP:0100796)2.38255640
47Pheochromocytoma (HP:0002666)2.34865060
48Lipid accumulation in hepatocytes (HP:0006561)2.34792701
49Abnormal hair whorl (HP:0010721)2.34587858
50Exertional dyspnea (HP:0002875)2.33034648
51Medial flaring of the eyebrow (HP:0010747)2.33021796
52Reduced antithrombin III activity (HP:0001976)2.32689740
53Hypoplasia of the fovea (HP:0007750)2.31649814
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.31649814
55Optic disc pallor (HP:0000543)2.31513843
56Abnormal drinking behavior (HP:0030082)2.29588916
57Polydipsia (HP:0001959)2.29588916
58Macrocytic anemia (HP:0001972)2.28804191
59Pendular nystagmus (HP:0012043)2.27080612
60Nephrogenic diabetes insipidus (HP:0009806)2.26421923
61Vacuolated lymphocytes (HP:0001922)2.25925484
62Type II lissencephaly (HP:0007260)2.24872874
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21496475
64Prostate neoplasm (HP:0100787)2.20204870
65Exercise intolerance (HP:0003546)2.17631914
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17195479
67Cystic liver disease (HP:0006706)2.16670231
68Chronic hepatic failure (HP:0100626)2.15870625
69Tubular atrophy (HP:0000092)2.15836992
70Increased intramyocellular lipid droplets (HP:0012240)2.14192321
71Thyroiditis (HP:0100646)2.13595377
72Bone cyst (HP:0012062)2.11536809
73Congenital primary aphakia (HP:0007707)2.10765314
74Reticulocytopenia (HP:0001896)2.09922018
75Febrile seizures (HP:0002373)2.08823154
76Type 2 muscle fiber atrophy (HP:0003554)2.08036653
77Sclerocornea (HP:0000647)2.07946009
78Chronic obstructive pulmonary disease (HP:0006510)2.07868737
79Obstructive lung disease (HP:0006536)2.07868737
80Cerebral edema (HP:0002181)2.06496987
81Conjunctival hamartoma (HP:0100780)2.06110929
82Concave nail (HP:0001598)2.06109564
83Chronic diarrhea (HP:0002028)2.05672296
84Recurrent skin infections (HP:0001581)2.05625146
85Lactic acidosis (HP:0003128)2.05517866
86Abnormality of renal resorption (HP:0011038)2.05492589
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04569711
88Decreased central vision (HP:0007663)2.02917455
89Chronic sinusitis (HP:0011109)2.01744101
90Recurrent gram-negative bacterial infections (HP:0005420)2.00517762
91Abnormality of the prostate (HP:0008775)2.00425973
92Abnormality of vitamin B metabolism (HP:0004340)2.00351880
93Gait imbalance (HP:0002141)1.98579618
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97538627
95Bile duct proliferation (HP:0001408)1.97076012
96Abnormal biliary tract physiology (HP:0012439)1.97076012
97Aplastic anemia (HP:0001915)1.95859894
98True hermaphroditism (HP:0010459)1.95161882
99Respiratory failure (HP:0002878)1.95028280
100Abnormality of the vitamin B12 metabolism (HP:0004341)1.93416899
101Focal motor seizures (HP:0011153)1.92568239
102Lethargy (HP:0001254)1.91545157
103Abnormal ciliary motility (HP:0012262)1.90606511
104Axonal loss (HP:0003447)1.90317722
105Chronic mucocutaneous candidiasis (HP:0002728)1.90182975
106Recurrent cutaneous fungal infections (HP:0011370)1.90182975
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90165443
108Mediastinal lymphadenopathy (HP:0100721)1.89876799
109Large for gestational age (HP:0001520)1.89593012
110Colon cancer (HP:0003003)1.89313527
111Congenital sensorineural hearing impairment (HP:0008527)1.89186245
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.88309294
113Absent/shortened dynein arms (HP:0200106)1.88309294
114Vasculitis (HP:0002633)1.88127345
115Renal cortical cysts (HP:0000803)1.87851004
116Abnormal respiratory epithelium morphology (HP:0012253)1.87785828
117Abnormal respiratory motile cilium morphology (HP:0005938)1.87785828
118Alveolar cell carcinoma (HP:0006519)1.87710479
119Polyuria (HP:0000103)1.87007622
120Neoplasm of the adrenal gland (HP:0100631)1.86284439
121Furrowed tongue (HP:0000221)1.86137620
122Abnormality of macular pigmentation (HP:0008002)1.85109674
123Meningitis (HP:0001287)1.84889443
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.84875211
125Pancreatic fibrosis (HP:0100732)1.83222523
126Symptomatic seizures (HP:0011145)1.82976055
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82865884
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82865884
129Male pseudohermaphroditism (HP:0000037)1.82716403
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.82367990
131Pulmonary infiltrates (HP:0002113)1.82091208
132Increased serum lactate (HP:0002151)1.81454587
133Anencephaly (HP:0002323)1.81184693
134Increased muscle lipid content (HP:0009058)1.80839772
135Abnormality of the pons (HP:0007361)1.80812454
136Recurrent fungal infections (HP:0002841)1.79568371
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78739310
138Rib fusion (HP:0000902)1.78373579
139Osteomyelitis (HP:0002754)1.78232918
140Abnormality of serum amino acid levels (HP:0003112)1.78118559
141Inability to walk (HP:0002540)1.77708086
142Recurrent pneumonia (HP:0006532)1.76709626
143Congenital hepatic fibrosis (HP:0002612)1.76320198
144Hypoplasia of the pons (HP:0012110)1.76213159
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.75987761
146Progressive inability to walk (HP:0002505)1.75855099
147Renal tubular dysfunction (HP:0000124)1.75667594
148Patchy hypopigmentation of hair (HP:0011365)1.75475714
149Abnormality of the fovea (HP:0000493)1.74998496
150Abnormality of urine glucose concentration (HP:0011016)1.74605246
151Glycosuria (HP:0003076)1.74605246
152Hyperventilation (HP:0002883)1.74535634
153Epileptic encephalopathy (HP:0200134)1.74098830
154Hypoglycemic seizures (HP:0002173)1.73471251
155Keratoconjunctivitis (HP:0001096)1.70884769
156Basal ganglia calcification (HP:0002135)1.69939901
157Abnormality of glycolipid metabolism (HP:0010969)1.68532993
158Abnormality of liposaccharide metabolism (HP:0010968)1.68532993
159Abnormality of glycosphingolipid metabolism (HP:0004343)1.68532993
160Keratoconjunctivitis sicca (HP:0001097)1.68061230
161Thyroid carcinoma (HP:0002890)1.67762829
162Premature loss of primary teeth (HP:0006323)1.66713936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.04745459
2TLK13.35501502
3MAP3K123.23131325
4BMPR23.06240833
5MAP3K142.70028323
6CASK2.65307964
7SIK32.59098596
8MAP4K22.30265650
9TNIK2.26204931
10GRK12.23147697
11TXK2.21644397
12STK162.21465237
13ACVR1B2.16549101
14IRAK42.15473398
15VRK21.97688529
16MUSK1.97337662
17GRK71.93999798
18ADRBK21.90691435
19TEC1.87152816
20RIPK41.86660969
21PRPF4B1.81724198
22MAP2K71.73169073
23IRAK31.66481178
24MST41.62462306
25BMPR1B1.62420869
26PINK11.55420428
27FES1.47584468
28WNK41.44882397
29ARAF1.42781957
30AKT31.41562295
31PIK3CG1.40854651
32OXSR11.39697225
33MKNK21.38867733
34PIM21.38696379
35MYLK1.32292388
36ERBB31.32074515
37IRAK11.31588833
38INSRR1.31470623
39TAOK31.30814162
40BUB11.30454091
41IKBKB1.26080471
42BLK1.25320935
43MAP3K131.17476971
44CCNB11.17063977
45TGFBR11.16475402
46KIT1.15405694
47IKBKE1.15015620
48SGK21.14673592
49FLT31.14405177
50BCKDK1.13780690
51CAMKK21.11115677
52DYRK21.10853233
53NEK91.09203859
54CDK81.07966742
55BTK1.07076616
56GRK51.04603098
57TIE11.01343632
58BRAF0.99416764
59NLK0.98144176
60MAPKAPK50.96863976
61SYK0.96400069
62ZAK0.92445518
63PLK40.90615431
64STK390.90260953
65PLK30.88188889
66PHKG20.85335850
67PHKG10.85335850
68CDK190.84219171
69WEE10.83623992
70EPHA30.83112683
71EIF2AK20.81672242
72NTRK30.80609092
73SGK2230.80104364
74SGK4940.80104364
75YES10.79719031
76TRIM280.79014757
77CDC70.78560557
78PNCK0.77940560
79OBSCN0.77210926
80PLK20.76323426
81BRSK20.75890695
82PRKCE0.74375519
83ADRBK10.74261181
84LYN0.73768106
85WNK30.72674989
86MAPK130.71016919
87NME20.69963985
88SRPK10.69631167
89BCR0.68531895
90DAPK20.67305096
91CSNK1G10.66793253
92TYK20.65597888
93RPS6KA50.65411406
94TBK10.65039329
95STK240.64555770
96NEK20.63429436
97TGFBR20.62870891
98VRK10.62439558
99KDR0.61625326
100EIF2AK30.61533908
101PRKCG0.61409428
102MAP4K10.60077562
103STK38L0.58721562
104NEK10.58714977
105MAPK150.57466339
106TRPM70.56816849
107PAK30.56123815
108JAK30.55746287
109PLK10.55247813
110CSNK1G20.54509398
111CSNK1G30.54048717
112FGFR30.53387693
113MAP3K40.52987368
114PASK0.52698055
115MKNK10.52687280
116IRAK20.52337927
117TSSK60.51251076
118TNK20.49857357
119TAF10.49591945
120ATR0.48725533
121PIK3CA0.48283908
122PRKACA0.46701340
123ZAP700.46671552
124NEK60.45874584
125FGFR20.45808553
126PDK20.45156399
127ITK0.44888953
128PRKCD0.43672761
129PBK0.42348294
130CHEK20.42029179
131CDK30.41684947
132CSNK2A10.41497053
133LCK0.41490505
134MAP2K20.40937799
135LIMK10.40457642
136NUAK10.39887729
137EIF2AK10.39048471
138STK30.38581371
139PKN10.37518399
140CSNK2A20.36952664
141AURKB0.36576711
142CHUK0.36463860
143HIPK20.36429510
144MAP2K60.36342170
145PRKCA0.35580406
146PRKCQ0.35231671
147CAMK2D0.33884828
148MATK0.33559236
149DAPK10.32653157
150CAMK2A0.32364149
151NME10.32095162

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.31011356
2Ribosome_Homo sapiens_hsa030103.95540370
3Oxidative phosphorylation_Homo sapiens_hsa001903.64458478
4Parkinsons disease_Homo sapiens_hsa050122.99226244
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.78474272
6Collecting duct acid secretion_Homo sapiens_hsa049662.52567550
7Rheumatoid arthritis_Homo sapiens_hsa053232.41990900
8Alzheimers disease_Homo sapiens_hsa050102.28916236
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18314149
10Asthma_Homo sapiens_hsa053102.01714993
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.00718868
12Graft-versus-host disease_Homo sapiens_hsa053321.99625536
13Allograft rejection_Homo sapiens_hsa053301.97465716
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94965130
15Huntingtons disease_Homo sapiens_hsa050161.91898779
16Linoleic acid metabolism_Homo sapiens_hsa005911.84311342
17Proteasome_Homo sapiens_hsa030501.76322941
18Fanconi anemia pathway_Homo sapiens_hsa034601.73923752
19Vibrio cholerae infection_Homo sapiens_hsa051101.71761530
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.69486104
21Nitrogen metabolism_Homo sapiens_hsa009101.67094041
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64328788
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64200456
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63816510
25Legionellosis_Homo sapiens_hsa051341.59300854
26Phagosome_Homo sapiens_hsa041451.54903819
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54288807
28Autoimmune thyroid disease_Homo sapiens_hsa053201.53160967
29Type I diabetes mellitus_Homo sapiens_hsa049401.52031768
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47416758
31RNA degradation_Homo sapiens_hsa030181.45709516
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44864724
33Caffeine metabolism_Homo sapiens_hsa002321.44181512
34Leishmaniasis_Homo sapiens_hsa051401.41348286
35Synaptic vesicle cycle_Homo sapiens_hsa047211.40227451
36Pertussis_Homo sapiens_hsa051331.39933444
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38730100
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35081734
39Selenocompound metabolism_Homo sapiens_hsa004501.34847215
40Sulfur metabolism_Homo sapiens_hsa009201.34477005
41Butanoate metabolism_Homo sapiens_hsa006501.33170573
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33101817
43Propanoate metabolism_Homo sapiens_hsa006401.30994005
44Other glycan degradation_Homo sapiens_hsa005111.30223595
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27570504
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21986013
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.21608644
48Serotonergic synapse_Homo sapiens_hsa047261.20095769
49Fatty acid elongation_Homo sapiens_hsa000621.18903528
50Tryptophan metabolism_Homo sapiens_hsa003801.18793214
51Chemical carcinogenesis_Homo sapiens_hsa052041.16225334
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14983074
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14100516
54One carbon pool by folate_Homo sapiens_hsa006701.13526176
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11752294
56Mismatch repair_Homo sapiens_hsa034301.10403265
57Nucleotide excision repair_Homo sapiens_hsa034201.08786587
58Primary immunodeficiency_Homo sapiens_hsa053401.07822299
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05245595
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.02326095
61African trypanosomiasis_Homo sapiens_hsa051431.01400256
62Nicotine addiction_Homo sapiens_hsa050330.99849955
63Retinol metabolism_Homo sapiens_hsa008300.98962872
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98007462
65Staphylococcus aureus infection_Homo sapiens_hsa051500.94153973
66Tuberculosis_Homo sapiens_hsa051520.94137145
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92953680
68Lysosome_Homo sapiens_hsa041420.91628966
69Hematopoietic cell lineage_Homo sapiens_hsa046400.89846746
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89564117
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88223886
72Measles_Homo sapiens_hsa051620.87164289
73RNA polymerase_Homo sapiens_hsa030200.86612235
74Arachidonic acid metabolism_Homo sapiens_hsa005900.86462334
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85114174
76Taste transduction_Homo sapiens_hsa047420.83816319
77Folate biosynthesis_Homo sapiens_hsa007900.80355002
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79103974
79Spliceosome_Homo sapiens_hsa030400.79099592
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78889820
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.78774570
82Vitamin digestion and absorption_Homo sapiens_hsa049770.78031685
83Morphine addiction_Homo sapiens_hsa050320.77990864
84Non-homologous end-joining_Homo sapiens_hsa034500.77013242
85Chemokine signaling pathway_Homo sapiens_hsa040620.76671557
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76557836
87Cardiac muscle contraction_Homo sapiens_hsa042600.72908337
88Osteoclast differentiation_Homo sapiens_hsa043800.71737659
89Malaria_Homo sapiens_hsa051440.71398716
90RNA transport_Homo sapiens_hsa030130.70311975
91DNA replication_Homo sapiens_hsa030300.69969731
92Olfactory transduction_Homo sapiens_hsa047400.69779692
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69237728
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.68555826
95Sphingolipid metabolism_Homo sapiens_hsa006000.68528712
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66867868
97Salmonella infection_Homo sapiens_hsa051320.66043116
98N-Glycan biosynthesis_Homo sapiens_hsa005100.64410642
99* Regulation of autophagy_Homo sapiens_hsa041400.63039288
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62246466
101TNF signaling pathway_Homo sapiens_hsa046680.61472753
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60320987
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59717991
104Fat digestion and absorption_Homo sapiens_hsa049750.58082329
105Influenza A_Homo sapiens_hsa051640.56730529
106Base excision repair_Homo sapiens_hsa034100.56343213
107Circadian entrainment_Homo sapiens_hsa047130.56132370
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55940554
109Circadian rhythm_Homo sapiens_hsa047100.54224490
110Peroxisome_Homo sapiens_hsa041460.53834488
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53571574
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52963926
113beta-Alanine metabolism_Homo sapiens_hsa004100.52250138
114Mineral absorption_Homo sapiens_hsa049780.50683962
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48913463
116Cocaine addiction_Homo sapiens_hsa050300.48190402
117Herpes simplex infection_Homo sapiens_hsa051680.47168004
118Insulin secretion_Homo sapiens_hsa049110.46714287
119Glutathione metabolism_Homo sapiens_hsa004800.45689343
120Sulfur relay system_Homo sapiens_hsa041220.44580004
121Histidine metabolism_Homo sapiens_hsa003400.44221991
122Purine metabolism_Homo sapiens_hsa002300.43347500
123Systemic lupus erythematosus_Homo sapiens_hsa053220.42767741
124Basal transcription factors_Homo sapiens_hsa030220.42067094
125Ether lipid metabolism_Homo sapiens_hsa005650.40696385
126Calcium signaling pathway_Homo sapiens_hsa040200.40674751
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.40425321
128B cell receptor signaling pathway_Homo sapiens_hsa046620.39397049
129Antigen processing and presentation_Homo sapiens_hsa046120.38977888
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.38608173
131Phenylalanine metabolism_Homo sapiens_hsa003600.38240187
132Amphetamine addiction_Homo sapiens_hsa050310.38171693
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37265717
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37144013
135Metabolic pathways_Homo sapiens_hsa011000.36906666
136Homologous recombination_Homo sapiens_hsa034400.36691072
137Steroid biosynthesis_Homo sapiens_hsa001000.36235836
138ABC transporters_Homo sapiens_hsa020100.35114067
139Ovarian steroidogenesis_Homo sapiens_hsa049130.34479995
140GABAergic synapse_Homo sapiens_hsa047270.34443985
141Fatty acid degradation_Homo sapiens_hsa000710.33990283
142Shigellosis_Homo sapiens_hsa051310.32076817
143Pyrimidine metabolism_Homo sapiens_hsa002400.31467895
144Dopaminergic synapse_Homo sapiens_hsa047280.31190577
145Tyrosine metabolism_Homo sapiens_hsa003500.30742911
146Phototransduction_Homo sapiens_hsa047440.29897537
147Pyruvate metabolism_Homo sapiens_hsa006200.28536516
148Renin secretion_Homo sapiens_hsa049240.27533784
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27280817
150Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25781885

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