ATG12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.51183870
2meiotic chromosome segregation (GO:0045132)5.44972047
3negative regulation of microtubule polymerization (GO:0031115)5.05688735
4protein K11-linked deubiquitination (GO:0035871)5.02665264
5synaptic vesicle maturation (GO:0016188)4.81657564
6nucleobase catabolic process (GO:0046113)4.69180604
7sequestering of actin monomers (GO:0042989)4.41578317
8peptidyl-threonine dephosphorylation (GO:0035970)4.38530484
9synaptic vesicle exocytosis (GO:0016079)4.28537918
10L-fucose catabolic process (GO:0042355)4.20527356
11fucose catabolic process (GO:0019317)4.20527356
12L-fucose metabolic process (GO:0042354)4.20527356
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.18690951
14rRNA methylation (GO:0031167)4.09554604
15UDP-N-acetylglucosamine metabolic process (GO:0006047)4.04289878
16rRNA modification (GO:0000154)3.91586361
17positive regulation of mitochondrial fission (GO:0090141)3.87643130
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87466106
19DNA double-strand break processing (GO:0000729)3.83481384
20negative regulation of dendrite morphogenesis (GO:0050774)3.80882405
21water-soluble vitamin biosynthetic process (GO:0042364)3.80679628
22rRNA catabolic process (GO:0016075)3.80404490
23platelet dense granule organization (GO:0060155)3.78175529
24melanosome localization (GO:0032400)3.77941056
25acrosome assembly (GO:0001675)3.75448399
26signal peptide processing (GO:0006465)3.71943509
27vocalization behavior (GO:0071625)3.71846980
28reciprocal DNA recombination (GO:0035825)3.58374002
29reciprocal meiotic recombination (GO:0007131)3.58374002
30protein K6-linked ubiquitination (GO:0085020)3.57219513
31pigment granule localization (GO:0051875)3.54105881
32layer formation in cerebral cortex (GO:0021819)3.52679237
33regulation of synaptic vesicle exocytosis (GO:2000300)3.47276233
34protein localization to microtubule (GO:0035372)3.43659849
35cullin deneddylation (GO:0010388)3.41725450
36neurofilament cytoskeleton organization (GO:0060052)3.38044236
37generation of neurons (GO:0048699)3.37589775
38regulation of cAMP-dependent protein kinase activity (GO:2000479)3.37021069
39snRNA processing (GO:0016180)3.33059522
40protein-cofactor linkage (GO:0018065)3.32612409
41mismatch repair (GO:0006298)3.31670783
42proteasome assembly (GO:0043248)3.29870332
43glutamate secretion (GO:0014047)3.29066125
44protein deneddylation (GO:0000338)3.25442871
45regulation of synaptic vesicle transport (GO:1902803)3.24883415
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24312925
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23960302
48response to pheromone (GO:0019236)3.20773911
49energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.20624169
50ATP hydrolysis coupled proton transport (GO:0015991)3.20624169
51transferrin transport (GO:0033572)3.20447190
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19183874
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19183874
54neurotransmitter-gated ion channel clustering (GO:0072578)3.17274694
55negative regulation of cell killing (GO:0031342)3.16668087
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16668087
57replication fork processing (GO:0031297)3.16233701
58neuron cell-cell adhesion (GO:0007158)3.15890448
59protein localization to synapse (GO:0035418)3.15871884
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.15345172
61behavioral response to nicotine (GO:0035095)3.12769503
62inner ear receptor stereocilium organization (GO:0060122)3.12327440
63phagocytosis, recognition (GO:0006910)3.11221535
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11053669
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10944788
66endosome to melanosome transport (GO:0035646)3.10768951
67endosome to pigment granule transport (GO:0043485)3.10768951
68proline transport (GO:0015824)3.10513061
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09478425
70histone H3-K4 trimethylation (GO:0080182)3.08185727
71photoreceptor cell maintenance (GO:0045494)3.07660585
72protein neddylation (GO:0045116)3.07543405
73de novo protein folding (GO:0006458)3.05509152
74protein complex biogenesis (GO:0070271)3.04874719
75adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04623500
76regulation of synapse structural plasticity (GO:0051823)3.03050107
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02711274
78postsynaptic membrane organization (GO:0001941)3.02105213
79regulation of meiosis I (GO:0060631)3.02018264
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01776532
81regulation of microtubule polymerization (GO:0031113)3.01160323
82neurotransmitter secretion (GO:0007269)3.01038821
83regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00753722
84regulation of mitotic spindle checkpoint (GO:1903504)3.00753722
85regulation of DNA endoreduplication (GO:0032875)2.99361598
86mitochondrial respiratory chain complex assembly (GO:0033108)2.98838719
87positive regulation of histone H3-K4 methylation (GO:0051571)2.98128610
88regulation of glutamate receptor signaling pathway (GO:1900449)2.97281134
89kynurenine metabolic process (GO:0070189)2.96963254
90auditory receptor cell stereocilium organization (GO:0060088)2.96895473
91respiratory chain complex IV assembly (GO:0008535)2.96863002
92chaperone-mediated protein transport (GO:0072321)2.96171902
93vesicle localization (GO:0051648)2.94423575
94somite development (GO:0061053)2.94189432
95mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94138459
96mitochondrial respiratory chain complex I assembly (GO:0032981)2.94138459
97NADH dehydrogenase complex assembly (GO:0010257)2.94138459
98negative regulation of DNA-dependent DNA replication (GO:2000104)2.94047882
99tryptophan catabolic process (GO:0006569)2.93904168
100indole-containing compound catabolic process (GO:0042436)2.93904168
101indolalkylamine catabolic process (GO:0046218)2.93904168
102regulation of nuclear cell cycle DNA replication (GO:0033262)2.93513495
103mitochondrion transport along microtubule (GO:0047497)2.90494115
104establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.90494115
105cell migration in hindbrain (GO:0021535)2.90131390
106ferric iron transport (GO:0015682)2.88811104
107trivalent inorganic cation transport (GO:0072512)2.88811104
108recombinational repair (GO:0000725)2.88584092
109adenosine metabolic process (GO:0046085)2.88496384
110mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.87960196
111nonmotile primary cilium assembly (GO:0035058)2.86500182
112double-strand break repair via homologous recombination (GO:0000724)2.85645326
113regulation of MHC class II biosynthetic process (GO:0045346)2.84534253
114de novo posttranslational protein folding (GO:0051084)2.84238789
115axon cargo transport (GO:0008088)2.83657247
116neural tube formation (GO:0001841)2.83534058
117magnesium ion transport (GO:0015693)2.81791496
118cilium morphogenesis (GO:0060271)2.81676069
119tachykinin receptor signaling pathway (GO:0007217)2.81553624
120DNA deamination (GO:0045006)2.80466222
121purine nucleobase biosynthetic process (GO:0009113)2.76234906
122negative regulation of dendrite development (GO:2000171)2.75680896
123N-acetylglucosamine metabolic process (GO:0006044)2.73605180
124axon regeneration (GO:0031103)2.73018638
125snRNA metabolic process (GO:0016073)2.72043527
126phagosome maturation (GO:0090382)2.71430572
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.71317881
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71317881
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71317881
130nucleotide transmembrane transport (GO:1901679)2.71070810
131regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.70813081
132exploration behavior (GO:0035640)2.70002170
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69594538
134regulation of mitochondrial fission (GO:0090140)2.69097415
135regulation of oxidative phosphorylation (GO:0002082)2.68982214
136cellular ketone body metabolic process (GO:0046950)2.68277628
137regulation of defense response to virus by virus (GO:0050690)2.67574213
138positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66287331
139dopamine receptor signaling pathway (GO:0007212)2.64711390
140anterograde synaptic vesicle transport (GO:0048490)2.64484874
141synapse assembly (GO:0007416)2.64010561
142cytochrome complex assembly (GO:0017004)2.62070761
143indolalkylamine metabolic process (GO:0006586)2.61152118
144regulation of translational termination (GO:0006449)2.59646977
145detection of light stimulus involved in sensory perception (GO:0050962)2.58797858
146detection of light stimulus involved in visual perception (GO:0050908)2.58797858
147locomotory exploration behavior (GO:0035641)2.57055361
148centriole replication (GO:0007099)2.56859298
149cilium organization (GO:0044782)2.56849740
150anterograde axon cargo transport (GO:0008089)2.56731801
151histone H2A acetylation (GO:0043968)2.56689717
152regulation of hexokinase activity (GO:1903299)2.56638255
153regulation of glucokinase activity (GO:0033131)2.56638255
154positive regulation of synapse maturation (GO:0090129)2.56393974
155negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.55388757
156regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55119749
157cellular copper ion homeostasis (GO:0006878)2.54714966
158cilium assembly (GO:0042384)2.52948689
159epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52597512
160negative regulation of protein polymerization (GO:0032272)2.52518582
161detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.52365440
162detection of temperature stimulus involved in sensory perception (GO:0050961)2.52365440
163positive regulation of glycoprotein biosynthetic process (GO:0010560)2.52298085
164negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.51779230
165barbed-end actin filament capping (GO:0051016)2.51594139
166antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.51455725
167antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.50115438
168antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.50115438
169positive regulation of protein complex disassembly (GO:0043243)2.50044820
170negative regulation of membrane potential (GO:0045837)2.49484959
171tryptophan metabolic process (GO:0006568)2.47672706
172mitochondrial RNA metabolic process (GO:0000959)2.46997273
173regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46851780
174nucleobase biosynthetic process (GO:0046112)2.46709222
175Golgi to endosome transport (GO:0006895)2.45979010
176pantothenate metabolic process (GO:0015939)2.45547590
177ncRNA catabolic process (GO:0034661)2.45207357
178negative regulation of mast cell activation (GO:0033004)2.44814149
179nucleobase-containing small molecule interconversion (GO:0015949)2.44433143
180regulation of protein kinase A signaling (GO:0010738)2.44056961
181intraciliary transport (GO:0042073)2.43319024
182neutrophil mediated immunity (GO:0002446)2.42338458
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42283854
184G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.41359598
185ketone body metabolic process (GO:1902224)2.40593617
186positive regulation of glycoprotein metabolic process (GO:1903020)2.40517157
187clathrin coat assembly (GO:0048268)2.40340113
188negative regulation of meiosis (GO:0045835)2.40135053
189positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.39374098
190synaptic vesicle transport (GO:0048489)2.39054681
191establishment of synaptic vesicle localization (GO:0097480)2.39054681
192axon extension (GO:0048675)2.37687619
193establishment of mitochondrion localization (GO:0051654)2.36225287
194regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.35731671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.71181108
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.22650162
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.11955866
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.00568296
5IGF1R_20145208_ChIP-Seq_DFB_Human3.75853884
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79228887
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67828047
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59246629
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43282174
10VDR_22108803_ChIP-Seq_LS180_Human2.42465039
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.39355575
12REST_21632747_ChIP-Seq_MESCs_Mouse2.36490572
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36477588
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.34763278
15GBX2_23144817_ChIP-Seq_PC3_Human2.32185312
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31343953
17EZH2_22144423_ChIP-Seq_EOC_Human2.30379451
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29201957
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.18684695
20* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17053327
21ZNF274_21170338_ChIP-Seq_K562_Hela2.16315308
22ELK1_19687146_ChIP-ChIP_HELA_Human2.14233723
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04034325
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97058377
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96723732
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96020512
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82592915
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79625035
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78612236
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75228331
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75193417
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72827154
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.69228144
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69212862
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66540412
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65630172
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63685469
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63606649
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62355250
40MYC_18940864_ChIP-ChIP_HL60_Human1.60883746
41AR_21572438_ChIP-Seq_LNCaP_Human1.57321363
42JUN_21703547_ChIP-Seq_K562_Human1.53302725
43EGR1_19032775_ChIP-ChIP_M12_Human1.52458975
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.51869803
45BCAT_22108803_ChIP-Seq_LS180_Human1.47315737
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.46729780
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45263755
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45098278
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44526151
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43798001
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43156312
52IRF1_19129219_ChIP-ChIP_H3396_Human1.42552093
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42431645
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42425362
55TAF15_26573619_Chip-Seq_HEK293_Human1.41850544
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41463309
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41462969
58VDR_23849224_ChIP-Seq_CD4+_Human1.40347011
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.39480881
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37998397
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37503715
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37100287
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36773511
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35989284
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35632097
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34287172
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34188925
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33682808
69TCF4_23295773_ChIP-Seq_U87_Human1.32872229
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32414044
71P300_19829295_ChIP-Seq_ESCs_Human1.30770956
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30481685
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.30384065
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.29727651
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.29574389
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29258926
77* EST1_17652178_ChIP-ChIP_JURKAT_Human1.28720550
78RNF2_27304074_Chip-Seq_NSC_Mouse1.28348672
79* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26859919
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26684563
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26511330
82TP53_22573176_ChIP-Seq_HFKS_Human1.26090770
83CDX2_22108803_ChIP-Seq_LS180_Human1.25126133
84* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24519774
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24032503
86STAT3_23295773_ChIP-Seq_U87_Human1.23098385
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22858632
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22128877
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21818316
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20707072
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20686690
92TCF4_22108803_ChIP-Seq_LS180_Human1.20262297
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20225755
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19658025
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.18869064
96SRF_21415370_ChIP-Seq_HL-1_Mouse1.18289292
97CRX_20693478_ChIP-Seq_RETINA_Mouse1.18130940
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.17343352
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16272119
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16026775
101SOX2_19829295_ChIP-Seq_ESCs_Human1.15896858
102NANOG_19829295_ChIP-Seq_ESCs_Human1.15896858
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15685695
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15002770
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14702938
106* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11586825
107EWS_26573619_Chip-Seq_HEK293_Human1.11226498
108* FOXP3_21729870_ChIP-Seq_TREG_Human1.10782127
109* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09695644
110* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09695644
111* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09538550
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09321698
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09321698
114SMAD4_21799915_ChIP-Seq_A2780_Human1.09037063
115P53_22387025_ChIP-Seq_ESCs_Mouse1.09014870
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06673435
117ZNF263_19887448_ChIP-Seq_K562_Human1.06394883
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06153312
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.06110945
120POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06051676
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.05341998
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.03124532
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.03102976
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02985307
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02965485
126CMYC_18555785_Chip-Seq_ESCs_Mouse1.01067363
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.00937311
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.00537989
129P300_18555785_Chip-Seq_ESCs_Mouse0.99311425
130SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98292957
131* RUNX2_22187159_ChIP-Seq_PCA_Human0.98268361
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98123555
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96951856
134STAT3_18555785_Chip-Seq_ESCs_Mouse0.96774743
135DCP1A_22483619_ChIP-Seq_HELA_Human0.96703928
136HOXB7_26014856_ChIP-Seq_BT474_Human0.96313140
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95428652
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94724084
139REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93718562
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93090344
141MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91404862
142UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90839599
143JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90549690
144ER_23166858_ChIP-Seq_MCF-7_Human0.90062269
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.88990892
146AR_25329375_ChIP-Seq_VCAP_Human0.88976150
147MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88560180
148CBP_20019798_ChIP-Seq_JUKART_Human0.88103189
149IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88103189
150TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85289152
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84821847
152MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84631501
153EZH2_27304074_Chip-Seq_ESCs_Mouse0.84318017
154SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84287447
155SMRT_27268052_Chip-Seq_Bcells_Human0.82622925
156FUS_26573619_Chip-Seq_HEK293_Human0.81791969
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81737697
158TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81274166
159SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80759516
160GABP_19822575_ChIP-Seq_HepG2_Human0.80667318
161GATA3_21867929_ChIP-Seq_TH1_Mouse0.80579409
162CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80457634
163MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79944115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.50654798
2MP0001968_abnormal_touch/_nociception4.14450399
3MP0002736_abnormal_nociception_after4.06973266
4MP0002735_abnormal_chemical_nociception3.93482966
5MP0003195_calcinosis3.33598196
6MP0003303_peritoneal_inflammation3.20069311
7MP0002734_abnormal_mechanical_nocicepti2.93808734
8MP0006276_abnormal_autonomic_nervous2.91347444
9MP0003635_abnormal_synaptic_transmissio2.89849774
10MP0006072_abnormal_retinal_apoptosis2.86172539
11MP0003880_abnormal_central_pattern2.85669838
12MP0004270_analgesia2.84482177
13MP0008877_abnormal_DNA_methylation2.80989693
14MP0002733_abnormal_thermal_nociception2.79684463
15MP0003656_abnormal_erythrocyte_physiolo2.75264271
16MP0002063_abnormal_learning/memory/cond2.66126321
17MP0004858_abnormal_nervous_system2.60784902
18MP0005646_abnormal_pituitary_gland2.58529730
19MP0003646_muscle_fatigue2.36401800
20MP0001970_abnormal_pain_threshold2.35098445
21MP0005253_abnormal_eye_physiology2.30602834
22MP0005551_abnormal_eye_electrophysiolog2.27695954
23MP0003329_amyloid_beta_deposits2.23862838
24MP0003011_delayed_dark_adaptation2.20442201
25MP0001440_abnormal_grooming_behavior2.11658356
26MP0009745_abnormal_behavioral_response2.10639228
27MP0002837_dystrophic_cardiac_calcinosis2.01834841
28MP0006292_abnormal_olfactory_placode1.96636355
29MP0006054_spinal_hemorrhage1.95358609
30MP0002064_seizures1.93280189
31MP0000427_abnormal_hair_cycle1.92683092
32MP0000569_abnormal_digit_pigmentation1.84838989
33MP0009046_muscle_twitch1.84185087
34MP0004811_abnormal_neuron_physiology1.81293305
35MP0002572_abnormal_emotion/affect_behav1.80862460
36MP0004215_abnormal_myocardial_fiber1.78532971
37MP0002638_abnormal_pupillary_reflex1.74576976
38MP0002184_abnormal_innervation1.70366804
39MP0004147_increased_porphyrin_level1.68584072
40MP0005367_renal/urinary_system_phenotyp1.68539407
41MP0000516_abnormal_urinary_system1.68539407
42MP0003221_abnormal_cardiomyocyte_apopto1.65075209
43MP0003136_yellow_coat_color1.64815997
44MP0005084_abnormal_gallbladder_morpholo1.63092128
45MP0005085_abnormal_gallbladder_physiolo1.60742934
46MP0003879_abnormal_hair_cell1.60493648
47MP0000631_abnormal_neuroendocrine_gland1.60316290
48MP0010386_abnormal_urinary_bladder1.58865479
49MP0000778_abnormal_nervous_system1.55882338
50MP0004924_abnormal_behavior1.52469480
51MP0005386_behavior/neurological_phenoty1.52469480
52MP0002067_abnormal_sensory_capabilities1.52101078
53MP0001188_hyperpigmentation1.51752323
54MP0002938_white_spotting1.51211310
55MP0000604_amyloidosis1.50891721
56MP0001502_abnormal_circadian_rhythm1.50824148
57MP0004885_abnormal_endolymph1.44629774
58MP0005645_abnormal_hypothalamus_physiol1.43275720
59MP0002928_abnormal_bile_duct1.41999261
60MP0003186_abnormal_redox_activity1.40826463
61MP0001764_abnormal_homeostasis1.35526828
62MP0000343_altered_response_to1.31789831
63MP0000647_abnormal_sebaceous_gland1.29016873
64MP0002234_abnormal_pharynx_morphology1.28234934
65MP0001986_abnormal_taste_sensitivity1.28204303
66MP0002557_abnormal_social/conspecific_i1.26541511
67MP0008569_lethality_at_weaning1.25262548
68MP0003172_abnormal_lysosome_physiology1.21995060
69MP0003183_abnormal_peptide_metabolism1.21087428
70MP0004043_abnormal_pH_regulation1.20915925
71MP0001984_abnormal_olfaction1.19628279
72MP0000371_diluted_coat_color1.19013423
73MP0001485_abnormal_pinna_reflex1.17064952
74MP0005332_abnormal_amino_acid1.15547760
75MP0001293_anophthalmia1.13170825
76MP0001177_atelectasis1.11769076
77MP0005423_abnormal_somatic_nervous1.11054787
78MP0005187_abnormal_penis_morphology1.10598158
79MP0005360_urolithiasis1.10435305
80MP0003937_abnormal_limbs/digits/tail_de1.10006082
81MP0004133_heterotaxia1.09139627
82MP0009764_decreased_sensitivity_to1.08972028
83MP0005310_abnormal_salivary_gland1.07034123
84MP0006036_abnormal_mitochondrial_physio1.06919393
85MP0002066_abnormal_motor_capabilities/c1.05791910
86MP0001324_abnormal_eye_pigmentation1.05359528
87MP0005195_abnormal_posterior_eye1.03085132
88MP0002132_abnormal_respiratory_system1.02884855
89MP0002909_abnormal_adrenal_gland1.02879273
90MP0004484_altered_response_of1.02493422
91MP0001905_abnormal_dopamine_level1.02100106
92MP0001529_abnormal_vocalization0.99666766
93MP0003119_abnormal_digestive_system0.99621167
94MP0002090_abnormal_vision0.99543304
95MP0008057_abnormal_DNA_replication0.98911502
96MP0002272_abnormal_nervous_system0.98477549
97MP0002751_abnormal_autonomic_nervous0.98164064
98MP0005464_abnormal_platelet_physiology0.98154418
99MP0003718_maternal_effect0.98040920
100MP0005391_vision/eye_phenotype0.97872258
101MP0008260_abnormal_autophagy0.95917371
102MP0006035_abnormal_mitochondrial_morpho0.95734607
103MP0000015_abnormal_ear_pigmentation0.94920832
104MP0003567_abnormal_fetal_cardiomyocyte0.94750751
105MP0000955_abnormal_spinal_cord0.93464726
106MP0008775_abnormal_heart_ventricle0.92048410
107MP0005535_abnormal_body_temperature0.92001594
108MP0002160_abnormal_reproductive_system0.91988453
109MP0002396_abnormal_hematopoietic_system0.91916003
110MP0008875_abnormal_xenobiotic_pharmacok0.91587232
111MP0009780_abnormal_chondrocyte_physiolo0.91559717
112MP0001286_abnormal_eye_development0.90120932
113MP0010094_abnormal_chromosome_stability0.88578443
114MP0004742_abnormal_vestibular_system0.88215590
115MP0001501_abnormal_sleep_pattern0.85248266
116MP0003283_abnormal_digestive_organ0.82820442
117MP0002095_abnormal_skin_pigmentation0.82772412
118MP0001486_abnormal_startle_reflex0.82072867
119MP0003252_abnormal_bile_duct0.81807821
120MP0005167_abnormal_blood-brain_barrier0.81707372
121MP0002693_abnormal_pancreas_physiology0.81344087
122MP0002882_abnormal_neuron_morphology0.81135922
123MP0004085_abnormal_heartbeat0.79931664
124MP0000538_abnormal_urinary_bladder0.79772036
125MP0004130_abnormal_muscle_cell0.78648545
126MP0005395_other_phenotype0.78609982
127MP0002254_reproductive_system_inflammat0.78371427
128MP0008874_decreased_physiological_sensi0.77893513
129MP0005166_decreased_susceptibility_to0.77800796
130MP0001756_abnormal_urination0.77301082
131MP0000230_abnormal_systemic_arterial0.77083801
132MP0003787_abnormal_imprinting0.76394681
133MP0002163_abnormal_gland_morphology0.76322865
134MP0002876_abnormal_thyroid_physiology0.76183096
135MP0002752_abnormal_somatic_nervous0.76054696
136MP0000358_abnormal_cell_content/0.75742249
137MP0002102_abnormal_ear_morphology0.74773765
138MP0000372_irregular_coat_pigmentation0.74755653
139MP0003724_increased_susceptibility_to0.73665991
140MP0002152_abnormal_brain_morphology0.71767212
141MP0009697_abnormal_copulation0.71090035
142MP0005389_reproductive_system_phenotype0.68791721
143MP0009785_altered_susceptibility_to0.63250578
144MP0002419_abnormal_innate_immunity0.62698884
145MP0002069_abnormal_eating/drinking_beha0.62593722
146MP0004233_abnormal_muscle_weight0.62457980
147MP0003121_genomic_imprinting0.62452383
148MP0003077_abnormal_cell_cycle0.62262470
149MP0001963_abnormal_hearing_physiology0.61224882
150MP0003122_maternal_imprinting0.60458938
151MP0001545_abnormal_hematopoietic_system0.60262763
152MP0005397_hematopoietic_system_phenotyp0.60262763
153MP0003436_decreased_susceptibility_to0.58613037
154MP0001119_abnormal_female_reproductive0.57028053
155MP0008058_abnormal_DNA_repair0.56444162
156MP0003123_paternal_imprinting0.54005887
157MP0001186_pigmentation_phenotype0.52803028
158MP0003693_abnormal_embryo_hatching0.52436906
159MP0003315_abnormal_perineum_morphology0.51038917
160MP0008872_abnormal_physiological_respon0.50873935
161MP0004142_abnormal_muscle_tone0.50426265

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.32979477
2Mutism (HP:0002300)4.30817080
3Pancreatic cysts (HP:0001737)4.20778276
4Focal motor seizures (HP:0011153)3.98508234
5Hypothermia (HP:0002045)3.95078321
6Pancreatic fibrosis (HP:0100732)3.92856020
7Abnormality of midbrain morphology (HP:0002418)3.87640038
8Molar tooth sign on MRI (HP:0002419)3.87640038
9True hermaphroditism (HP:0010459)3.80678894
10Fetal akinesia sequence (HP:0001989)3.69790134
11Cortical dysplasia (HP:0002539)3.47093069
12Limb dystonia (HP:0002451)3.42833830
13Generalized hypopigmentation of hair (HP:0011358)3.38284999
14Polyphagia (HP:0002591)3.31972108
15Visual hallucinations (HP:0002367)3.28801441
16Medial flaring of the eyebrow (HP:0010747)3.27588213
17Lower limb asymmetry (HP:0100559)3.25786831
18Amyotrophic lateral sclerosis (HP:0007354)3.20254010
19Abnormality of alanine metabolism (HP:0010916)3.11622111
20Hyperalaninemia (HP:0003348)3.11622111
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11622111
22Nephronophthisis (HP:0000090)3.11474211
23Chronic hepatic failure (HP:0100626)2.97886214
24Epileptic encephalopathy (HP:0200134)2.96578525
25Abnormality of the lumbar spine (HP:0100712)2.95207357
26Ankle clonus (HP:0011448)2.93536999
27Delusions (HP:0000746)2.91935733
28Abnormality of the motor neurons (HP:0002450)2.83577696
29Abnormal neuron morphology (HP:0012757)2.83577696
30Attenuation of retinal blood vessels (HP:0007843)2.81622782
31Abnormal rod and cone electroretinograms (HP:0008323)2.77749646
32Focal seizures (HP:0007359)2.77283973
33Birth length less than 3rd percentile (HP:0003561)2.76145290
34Congenital stationary night blindness (HP:0007642)2.76050071
35Atrophy/Degeneration involving motor neurons (HP:0007373)2.75519494
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.75486548
37Abnormality of the renal cortex (HP:0011035)2.73947638
38Progressive inability to walk (HP:0002505)2.72405329
39Oligomenorrhea (HP:0000876)2.71511260
40Abnormal eating behavior (HP:0100738)2.68638522
41Abnormality of the renal medulla (HP:0100957)2.68436653
42Unsteady gait (HP:0002317)2.64549611
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64135469
44Broad-based gait (HP:0002136)2.63758917
45Increased serum pyruvate (HP:0003542)2.58520267
46Abnormality of glycolysis (HP:0004366)2.58520267
47Absence seizures (HP:0002121)2.58343320
48Personality changes (HP:0000751)2.58194948
49Acute necrotizing encephalopathy (HP:0006965)2.57284168
50Congenital primary aphakia (HP:0007707)2.56362487
51Gait imbalance (HP:0002141)2.56307432
52Torticollis (HP:0000473)2.55780524
53Abnormal biliary tract physiology (HP:0012439)2.53010660
54Bile duct proliferation (HP:0001408)2.53010660
55Progressive macrocephaly (HP:0004481)2.51247432
56Craniofacial dystonia (HP:0012179)2.48151465
57Shoulder girdle muscle weakness (HP:0003547)2.47570107
58Neoplasm of the adrenal gland (HP:0100631)2.44142504
59Drooling (HP:0002307)2.42640125
60Excessive salivation (HP:0003781)2.42640125
61Rimmed vacuoles (HP:0003805)2.41914802
62Increased CSF lactate (HP:0002490)2.41623838
63Congenital, generalized hypertrichosis (HP:0004540)2.41442146
64Decreased central vision (HP:0007663)2.40910604
65Methylmalonic acidemia (HP:0002912)2.40684415
66Mitochondrial inheritance (HP:0001427)2.40579525
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.40485172
68Focal dystonia (HP:0004373)2.38994884
69Type II lissencephaly (HP:0007260)2.37692762
70Diminished motivation (HP:0000745)2.37626184
71Increased hepatocellular lipid droplets (HP:0006565)2.35054121
72Atonic seizures (HP:0010819)2.32924676
73Poor suck (HP:0002033)2.32599274
74Nephrogenic diabetes insipidus (HP:0009806)2.32573763
75Urinary urgency (HP:0000012)2.32380965
76Pendular nystagmus (HP:0012043)2.31877543
77Papilledema (HP:0001085)2.31586335
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27298085
79Thyroid-stimulating hormone excess (HP:0002925)2.27015149
80Bony spicule pigmentary retinopathy (HP:0007737)2.26786830
81Lissencephaly (HP:0001339)2.26762291
82Neuroendocrine neoplasm (HP:0100634)2.26384106
83Apathy (HP:0000741)2.26219336
84Progressive microcephaly (HP:0000253)2.25715245
85Abnormality of the vocal cords (HP:0008777)2.25519837
86Tubular atrophy (HP:0000092)2.25279532
87Viral hepatitis (HP:0006562)2.23352817
88Genital tract atresia (HP:0001827)2.21861491
89Renal cortical cysts (HP:0000803)2.20627857
90Acute encephalopathy (HP:0006846)2.19883067
91Dialeptic seizures (HP:0011146)2.19363856
92Febrile seizures (HP:0002373)2.19313700
93Furrowed tongue (HP:0000221)2.18817387
94Vaginal atresia (HP:0000148)2.18043090
95Neoplasm of the adrenal cortex (HP:0100641)2.17598033
96Impaired pain sensation (HP:0007328)2.17324867
97Abnormality of pain sensation (HP:0010832)2.17324867
98Lipid accumulation in hepatocytes (HP:0006561)2.17246690
99Generalized hypopigmentation (HP:0007513)2.17107172
100Abnormal drinking behavior (HP:0030082)2.16123154
101Polydipsia (HP:0001959)2.16123154
102Anencephaly (HP:0002323)2.16089301
103Inability to walk (HP:0002540)2.15281685
104Sclerocornea (HP:0000647)2.12749792
105Inappropriate behavior (HP:0000719)2.12005438
106Hyperphosphaturia (HP:0003109)2.10782636
107Congenital hepatic fibrosis (HP:0002612)2.10409831
108Generalized tonic-clonic seizures (HP:0002069)2.10335775
109Intestinal atresia (HP:0011100)2.09895963
110Pigmentary retinal degeneration (HP:0001146)2.09086904
111Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08951256
1123-Methylglutaconic aciduria (HP:0003535)2.08234913
113Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08047700
114Hypoplasia of the brainstem (HP:0002365)2.08047700
115Pachygyria (HP:0001302)2.07234130
116Loss of speech (HP:0002371)2.06665324
117Cystic liver disease (HP:0006706)2.05532703
118Abnormal mitochondria in muscle tissue (HP:0008316)2.03935092
119Disinhibition (HP:0000734)2.02468659
120Abolished electroretinogram (ERG) (HP:0000550)2.01478476
121Hypoplasia of the fovea (HP:0007750)2.00851000
122Aplasia/Hypoplasia of the fovea (HP:0008060)2.00851000
123Respiratory difficulties (HP:0002880)1.99768769
124Impaired vibration sensation in the lower limbs (HP:0002166)1.99645439
125Abnormality of the labia minora (HP:0012880)1.98051220
126Abnormal hair whorl (HP:0010721)1.97537817
127Postaxial foot polydactyly (HP:0001830)1.96986528
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.96886773
129Abnormality of placental membranes (HP:0011409)1.96747611
130Amniotic constriction ring (HP:0009775)1.96747611
131Akinesia (HP:0002304)1.96499308
132Gaze-evoked nystagmus (HP:0000640)1.96323476
133Hepatocellular necrosis (HP:0001404)1.96251643
134Increased corneal curvature (HP:0100692)1.96085582
135Keratoconus (HP:0000563)1.96085582
136Abnormality of the anterior horn cell (HP:0006802)1.95075931
137Degeneration of anterior horn cells (HP:0002398)1.95075931
138Male pseudohermaphroditism (HP:0000037)1.94737640
139Meckel diverticulum (HP:0002245)1.94657554
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.93980785
141Abnormality of macular pigmentation (HP:0008002)1.92554340
142Abnormality of the corticospinal tract (HP:0002492)1.91612879
143Choroideremia (HP:0001139)1.91035887
144Methylmalonic aciduria (HP:0012120)1.90669946
145Heterochromia iridis (HP:0001100)1.90553511
146Hyperventilation (HP:0002883)1.89880518
147Increased intramyocellular lipid droplets (HP:0012240)1.89755224
148Chronic bronchitis (HP:0004469)1.89321607
149Poor speech (HP:0002465)1.88900202
150Sleep apnea (HP:0010535)1.87895364
151Truncal ataxia (HP:0002078)1.87681606
152Abnormality of the ileum (HP:0001549)1.87339139
153Abnormality of the pons (HP:0007361)1.86902821
154Neoplasm of the peripheral nervous system (HP:0100007)1.85817660
155Retinitis pigmentosa (HP:0000510)1.85562039
156Hypoplasia of the pons (HP:0012110)1.85415521
157Sloping forehead (HP:0000340)1.85403246
158Poor coordination (HP:0002370)1.84902968
159Occipital encephalocele (HP:0002085)1.84370156
160Agitation (HP:0000713)1.84215181
161Postaxial hand polydactyly (HP:0001162)1.83336163
162Hepatic necrosis (HP:0002605)1.82298208
163Abnormality of chromosome stability (HP:0003220)1.81902774
164Glioma (HP:0009733)1.81578134
165Iris hypopigmentation (HP:0007730)1.81278529
166Pelvic girdle muscle weakness (HP:0003749)1.81197859
167Disproportionate short-trunk short stature (HP:0003521)1.81071980
168Cerebellar dysplasia (HP:0007033)1.80911934
169Poor eye contact (HP:0000817)1.80539290
170Frequent falls (HP:0002359)1.80122688
171Ependymoma (HP:0002888)1.79628187
172Pheochromocytoma (HP:0002666)1.78730213
173Asymmetric growth (HP:0100555)1.78307498
174Enlarged kidneys (HP:0000105)1.77800894
175Increased muscle lipid content (HP:0009058)1.77428283
176Increased serum lactate (HP:0002151)1.76767371
177Amblyopia (HP:0000646)1.76559640
178Polymicrogyria (HP:0002126)1.76540369
179Thyroiditis (HP:0100646)1.76391474
180Astigmatism (HP:0000483)1.75042763
181Hemiparesis (HP:0001269)1.73730828
182Renal Fanconi syndrome (HP:0001994)1.73505547
183Aplasia/hypoplasia of the uterus (HP:0008684)1.73336141
184Fair hair (HP:0002286)1.73166354
185Biliary tract neoplasm (HP:0100574)1.72259947
186Preaxial hand polydactyly (HP:0001177)1.72204416
187Abnormality of the fovea (HP:0000493)1.71931527
188Colon cancer (HP:0003003)1.68084790
189Optic disc pallor (HP:0000543)1.67958595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.67588296
2MAP3K123.91393987
3CASK2.97231541
4MINK12.94176101
5BLK2.76362024
6TRIM282.67611996
7MAP2K72.58770535
8BMPR1B2.47693199
9ERBB32.44823024
10ZAK2.41580702
11NUAK12.37024829
12MST42.32481591
13MAP3K42.22445882
14LATS22.17676443
15MAP4K22.17614904
16LMTK22.08029200
17MKNK22.07042887
18LIMK12.04752907
19BCKDK1.99201910
20MAP3K91.96854586
21PDK41.91896390
22PDK31.91896390
23MAP3K61.89166539
24TNIK1.83387051
25NTRK21.81582998
26DAPK21.81045151
27SCYL21.80666770
28PLK21.74035948
29MAPK131.70667612
30DYRK21.68072816
31NTRK31.67742411
32BCR1.65471595
33DAPK11.64742955
34WNK31.63069612
35MAP2K41.57807238
36ARAF1.54624464
37PINK11.54394811
38TSSK61.51538852
39ADRBK21.50596607
40TESK11.41254099
41STK161.39390989
42GRK11.35038355
43STK391.27933572
44EIF2AK31.24655008
45MKNK11.23998893
46RET1.19315099
47STK38L1.15062897
48KSR11.14800813
49BRSK21.12200711
50PLK31.11029603
51CCNB11.08369426
52MAP2K61.07871274
53TLK11.07602832
54GRK51.07049240
55WNK41.06304585
56RPS6KA21.05940355
57FES1.03094205
58PLK41.02970193
59WEE11.02631065
60MAP3K51.00662228
61INSRR1.00411832
62OXSR11.00215825
63CSNK1G21.00081437
64BMPR20.98780057
65EPHA40.96757433
66CSNK1G30.95924238
67MAPKAPK30.93946000
68TAF10.92885563
69VRK10.91498298
70PIM20.87179185
71RAF10.86498683
72KSR20.86287789
73STK30.85373448
74CDK180.84921261
75CDK140.83540497
76PHKG20.83450027
77PHKG10.83450027
78RPS6KA40.83379543
79PAK30.81673175
80PDK20.79590726
81SIK30.78314967
82NEK10.77071673
83ABL20.76954665
84FGFR20.76635729
85FER0.76474865
86PLK10.75533360
87CDK150.74899623
88BUB10.72941374
89PRKCZ0.71749631
90CDK50.70618856
91DYRK1A0.69660773
92MAPKAPK50.69136228
93GRK70.68356574
94NEK20.68165052
95RIPK40.67376545
96TAOK20.66924603
97YES10.66163887
98AKT30.64715253
99EIF2AK20.63552755
100PRPF4B0.62632130
101TYRO30.61534784
102CDK11A0.61153558
103CAMKK20.60720559
104BRAF0.60143906
105CAMKK10.58299887
106FGFR30.58047147
107PTK2B0.57554055
108IRAK40.57193029
109PAK60.57081125
110ILK0.56741811
111PBK0.55236156
112TIE10.54634423
113MAP2K30.53765451
114EEF2K0.53101611
115MYLK0.51472405
116PRKCG0.51098840
117BRSK10.51090459
118FGFR10.49811064
119AURKA0.49477287
120ADRBK10.49359094
121PRKCI0.49024715
122SRPK10.48871903
123ZAP700.47596731
124PKN10.47376422
125CSNK1A1L0.47189117
126ACVR1B0.47124341
127TNK20.46966232
128PRKCE0.46302406
129CSNK1G10.45831781
130MAP3K30.45459293
131CAMK1D0.45320997
132CAMK40.44515137
133DYRK30.44473652
134CAMK2A0.43592702
135MAP2K10.43142077
136SYK0.42483327
137MUSK0.39678065
138STK240.39441610
139CSNK1E0.38812757
140TTK0.37913568
141FRK0.36324875
142PRKCQ0.36145207
143NLK0.35627990
144LATS10.34594418
145RPS6KB20.33678831
146MAPK40.33098510
147TEC0.33093509
148TAOK30.33079501
149ATR0.33001620
150GRK60.32689424
151EIF2AK10.31617249
152CSNK1A10.31572869
153ROCK10.31398320
154CAMK2B0.31080789
155TRPM70.30935037
156PRKD30.30619720
157PAK40.30542990
158RPS6KA50.30241419
159CHEK20.30209821

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.43755710
2Protein export_Homo sapiens_hsa030603.45611747
3Collecting duct acid secretion_Homo sapiens_hsa049663.00140949
4Olfactory transduction_Homo sapiens_hsa047402.90045611
5Propanoate metabolism_Homo sapiens_hsa006402.86099539
6Proteasome_Homo sapiens_hsa030502.65484669
7Nicotine addiction_Homo sapiens_hsa050332.41374811
8Dopaminergic synapse_Homo sapiens_hsa047282.25286845
9Caffeine metabolism_Homo sapiens_hsa002322.22450659
10Phototransduction_Homo sapiens_hsa047442.10445216
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07356698
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01844583
13Homologous recombination_Homo sapiens_hsa034402.01208889
14Fanconi anemia pathway_Homo sapiens_hsa034601.98804224
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98579488
16Vibrio cholerae infection_Homo sapiens_hsa051101.97725621
17Linoleic acid metabolism_Homo sapiens_hsa005911.97492609
18Phagosome_Homo sapiens_hsa041451.95986165
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93033345
20RNA degradation_Homo sapiens_hsa030181.92766695
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90423120
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.86217549
23Long-term potentiation_Homo sapiens_hsa047201.80369254
24One carbon pool by folate_Homo sapiens_hsa006701.77795003
25Non-homologous end-joining_Homo sapiens_hsa034501.75799336
26Oocyte meiosis_Homo sapiens_hsa041141.75180927
27Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.72689102
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71365143
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67533539
30Butanoate metabolism_Homo sapiens_hsa006501.67220926
31Sulfur metabolism_Homo sapiens_hsa009201.64286018
32Circadian entrainment_Homo sapiens_hsa047131.61940045
33Mismatch repair_Homo sapiens_hsa034301.59708530
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.56264891
35Oxidative phosphorylation_Homo sapiens_hsa001901.53488703
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53363463
37Amphetamine addiction_Homo sapiens_hsa050311.52680899
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.51806967
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49973055
40Tryptophan metabolism_Homo sapiens_hsa003801.49612833
41Cholinergic synapse_Homo sapiens_hsa047251.47824300
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47080370
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46454380
44Parkinsons disease_Homo sapiens_hsa050121.44678263
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40380690
46Ether lipid metabolism_Homo sapiens_hsa005651.40229116
47GABAergic synapse_Homo sapiens_hsa047271.36197643
48Morphine addiction_Homo sapiens_hsa050321.36138194
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35668025
50Endometrial cancer_Homo sapiens_hsa052131.34287835
51Nitrogen metabolism_Homo sapiens_hsa009101.32457415
52Steroid biosynthesis_Homo sapiens_hsa001001.28871706
53Huntingtons disease_Homo sapiens_hsa050161.24865168
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22811022
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22649982
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20673264
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16882483
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16195074
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13998560
60Pyruvate metabolism_Homo sapiens_hsa006201.13361782
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11046321
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10700579
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09995673
64Gap junction_Homo sapiens_hsa045401.08287902
65Peroxisome_Homo sapiens_hsa041461.05785399
66Tuberculosis_Homo sapiens_hsa051521.04635174
67Selenocompound metabolism_Homo sapiens_hsa004501.03365291
68Fatty acid degradation_Homo sapiens_hsa000711.01000183
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.99638067
70Glioma_Homo sapiens_hsa052140.98560487
71Serotonergic synapse_Homo sapiens_hsa047260.98111341
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97562144
73Long-term depression_Homo sapiens_hsa047300.97478720
74* Regulation of autophagy_Homo sapiens_hsa041400.97176225
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96180661
76Nucleotide excision repair_Homo sapiens_hsa034200.95510520
77Cocaine addiction_Homo sapiens_hsa050300.94114275
78Alzheimers disease_Homo sapiens_hsa050100.93561786
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92507623
80Glutamatergic synapse_Homo sapiens_hsa047240.92418119
81Folate biosynthesis_Homo sapiens_hsa007900.92017650
82Circadian rhythm_Homo sapiens_hsa047100.89616306
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89324835
84RNA polymerase_Homo sapiens_hsa030200.85251629
85GnRH signaling pathway_Homo sapiens_hsa049120.82367925
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82312642
87Fatty acid metabolism_Homo sapiens_hsa012120.82246195
88Pertussis_Homo sapiens_hsa051330.81980963
89Basal transcription factors_Homo sapiens_hsa030220.79647381
90Mineral absorption_Homo sapiens_hsa049780.78617413
91Salmonella infection_Homo sapiens_hsa051320.78144487
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77653664
93Rheumatoid arthritis_Homo sapiens_hsa053230.76595436
94Thyroid cancer_Homo sapiens_hsa052160.75539852
95VEGF signaling pathway_Homo sapiens_hsa043700.75458951
96Pentose phosphate pathway_Homo sapiens_hsa000300.75422613
97Colorectal cancer_Homo sapiens_hsa052100.74251590
98Legionellosis_Homo sapiens_hsa051340.74118483
99Salivary secretion_Homo sapiens_hsa049700.72295665
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.70701469
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69469486
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69325943
103Pyrimidine metabolism_Homo sapiens_hsa002400.68732040
104Axon guidance_Homo sapiens_hsa043600.67525349
105Metabolic pathways_Homo sapiens_hsa011000.67118935
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65884903
107ErbB signaling pathway_Homo sapiens_hsa040120.65394218
108Epstein-Barr virus infection_Homo sapiens_hsa051690.64043066
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63296954
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63193175
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62311363
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62263105
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61804717
114Oxytocin signaling pathway_Homo sapiens_hsa049210.61477573
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.61102485
116Retinol metabolism_Homo sapiens_hsa008300.60860828
117Spliceosome_Homo sapiens_hsa030400.60512876
118N-Glycan biosynthesis_Homo sapiens_hsa005100.60321874
119Purine metabolism_Homo sapiens_hsa002300.59975910
120Cardiac muscle contraction_Homo sapiens_hsa042600.59727190
121Renin secretion_Homo sapiens_hsa049240.59664706
122Estrogen signaling pathway_Homo sapiens_hsa049150.59348699
123Leishmaniasis_Homo sapiens_hsa051400.58160738
124Alcoholism_Homo sapiens_hsa050340.56742955
125Apoptosis_Homo sapiens_hsa042100.56295752
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55933906
127RNA transport_Homo sapiens_hsa030130.55520910
128Hedgehog signaling pathway_Homo sapiens_hsa043400.53185489
129Endocytosis_Homo sapiens_hsa041440.52875959
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51936271
131Chemical carcinogenesis_Homo sapiens_hsa052040.50673606
132mTOR signaling pathway_Homo sapiens_hsa041500.50542352
133mRNA surveillance pathway_Homo sapiens_hsa030150.49571963
134Taste transduction_Homo sapiens_hsa047420.49300243
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49262188
136Prolactin signaling pathway_Homo sapiens_hsa049170.48761279
137Gastric acid secretion_Homo sapiens_hsa049710.48322851
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47380183
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45998277
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45651384
141Arachidonic acid metabolism_Homo sapiens_hsa005900.45373835
142Lysosome_Homo sapiens_hsa041420.45318991
143p53 signaling pathway_Homo sapiens_hsa041150.45081038
144Base excision repair_Homo sapiens_hsa034100.45022407
145Calcium signaling pathway_Homo sapiens_hsa040200.44415746
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43316888
147Cell cycle_Homo sapiens_hsa041100.40737165
148Insulin secretion_Homo sapiens_hsa049110.39555159
149Glutathione metabolism_Homo sapiens_hsa004800.38712535
150Influenza A_Homo sapiens_hsa051640.38154612
151Sulfur relay system_Homo sapiens_hsa041220.38091467
152Hepatitis C_Homo sapiens_hsa051600.37974861
153Insulin signaling pathway_Homo sapiens_hsa049100.37848263
154* FoxO signaling pathway_Homo sapiens_hsa040680.36881005
155Melanogenesis_Homo sapiens_hsa049160.36135877
156Fat digestion and absorption_Homo sapiens_hsa049750.32502667
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32134639
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31565207
159Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31019915
160PPAR signaling pathway_Homo sapiens_hsa033200.30780038
161beta-Alanine metabolism_Homo sapiens_hsa004100.30410154
162Lysine degradation_Homo sapiens_hsa003100.28619243
163Vitamin B6 metabolism_Homo sapiens_hsa007500.27693524

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