ATG12P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of centriole replication (GO:0046599)7.15405045
2histone H3-K9 demethylation (GO:0033169)6.54104671
3melanin biosynthetic process (GO:0042438)6.17986261
4negative regulation of organelle assembly (GO:1902116)5.67431719
5melanin metabolic process (GO:0006582)5.53552856
6secondary metabolite biosynthetic process (GO:0044550)5.23330348
7positive regulation of chemokine secretion (GO:0090197)5.03625260
8negative regulation of fatty acid biosynthetic process (GO:0045717)4.99754270
9adaptation of signaling pathway (GO:0023058)4.92339625
10regulation of meiosis I (GO:0060631)4.78556183
11mitotic sister chromatid segregation (GO:0000070)4.63086587
12dosage compensation (GO:0007549)4.44786058
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.40611050
14signal peptide processing (GO:0006465)4.36949564
15regulation of centrosome duplication (GO:0010824)4.36030173
16long-chain fatty acid biosynthetic process (GO:0042759)4.33422874
17sister chromatid segregation (GO:0000819)4.32100496
18regulation of chemokine secretion (GO:0090196)4.29641509
19negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.20019415
20regulation of centrosome cycle (GO:0046605)4.04696968
21removal of superoxide radicals (GO:0019430)3.93387406
22cellular response to superoxide (GO:0071451)3.93387406
23cellular response to oxygen radical (GO:0071450)3.93387406
24protein K6-linked ubiquitination (GO:0085020)3.88038986
25endosome to melanosome transport (GO:0035646)3.87509306
26endosome to pigment granule transport (GO:0043485)3.87509306
27monoubiquitinated protein deubiquitination (GO:0035520)3.83395922
28blastocyst development (GO:0001824)3.74259522
29regulation of tight junction assembly (GO:2000810)3.71686595
30negative regulation of meiosis (GO:0045835)3.66913117
31regulation of cholesterol esterification (GO:0010872)3.66173980
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.61706410
33synaptonemal complex assembly (GO:0007130)3.60775462
34pigment cell differentiation (GO:0050931)3.60300933
35negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.55065806
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.55065806
37regulation of translation, ncRNA-mediated (GO:0045974)3.55065806
38nitric oxide biosynthetic process (GO:0006809)3.54061092
39linoleic acid metabolic process (GO:0043651)3.52835208
40negative regulation of histone acetylation (GO:0035067)3.51912373
41regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.51011582
42synaptonemal complex organization (GO:0070193)3.46187343
43melanocyte differentiation (GO:0030318)3.38289001
44high-density lipoprotein particle remodeling (GO:0034375)3.36702728
45cellular copper ion homeostasis (GO:0006878)3.34307089
46protein prenylation (GO:0018342)3.31926158
47prenylation (GO:0097354)3.31926158
48sister chromatid cohesion (GO:0007062)3.30178902
49negative regulation of neurological system process (GO:0031645)3.29431972
50attachment of spindle microtubules to kinetochore (GO:0008608)3.28189393
51response to superoxide (GO:0000303)3.25294330
52low-density lipoprotein particle remodeling (GO:0034374)3.22097273
53regulation of hippo signaling (GO:0035330)3.20185182
54mitotic chromosome condensation (GO:0007076)3.18950032
55histone lysine demethylation (GO:0070076)3.16302466
56regulation of DNA endoreduplication (GO:0032875)3.14734663
57negative regulation of receptor-mediated endocytosis (GO:0048261)3.08666705
58melanosome organization (GO:0032438)3.08209546
59positive regulation of histone H3-K4 methylation (GO:0051571)3.08194528
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08159369
61positive regulation of keratinocyte differentiation (GO:0045618)3.06666875
62positive regulation of response to oxidative stress (GO:1902884)3.05881048
63positive regulation of cellular response to oxidative stress (GO:1900409)3.05881048
64positive regulation of T cell cytokine production (GO:0002726)3.03999540
65protein localization to kinetochore (GO:0034501)2.99845880
66positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.97268165
67positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94345516
68DNA ligation (GO:0006266)2.94273163
69regulation of non-canonical Wnt signaling pathway (GO:2000050)2.94061972
70response to oxygen radical (GO:0000305)2.91993445
71protein demethylation (GO:0006482)2.91897292
72protein dealkylation (GO:0008214)2.91897292
73histone demethylation (GO:0016577)2.89990788
74negative regulation of protein localization to cell surface (GO:2000009)2.89360905
75centrosome organization (GO:0051297)2.88723561
76plasma membrane repair (GO:0001778)2.87315663
774-hydroxyproline metabolic process (GO:0019471)2.87217266
78pigment granule organization (GO:0048753)2.87144812
79negative regulation of peptidyl-lysine acetylation (GO:2000757)2.86662440
80pre-miRNA processing (GO:0031054)2.84737020
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83858318
82regulation of mitotic spindle checkpoint (GO:1903504)2.83858318
83regulation of pigment cell differentiation (GO:0050932)2.83168007
84neuroepithelial cell differentiation (GO:0060563)2.82983510
85musculoskeletal movement (GO:0050881)2.80042895
86multicellular organismal movement (GO:0050879)2.80042895
87negative regulation of fatty acid metabolic process (GO:0045922)2.77747656
88centriole replication (GO:0007099)2.77025787
89regulation of cytokine secretion involved in immune response (GO:0002739)2.76129530
90ER overload response (GO:0006983)2.75089947
91positive regulation of DNA repair (GO:0045739)2.74008044
92chromosome organization involved in meiosis (GO:0070192)2.73322605
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70764925
94reverse cholesterol transport (GO:0043691)2.69121584
95pericardium development (GO:0060039)2.68083336
96positive regulation of mRNA processing (GO:0050685)2.67099305
97paraxial mesoderm development (GO:0048339)2.66989694
98nodal signaling pathway (GO:0038092)2.65158138
99notochord development (GO:0030903)2.64512574
100peptidyl-proline hydroxylation (GO:0019511)2.63985988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.80271012
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.35758025
3AR_21909140_ChIP-Seq_LNCAP_Human3.61128966
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.12247732
5PIAS1_25552417_ChIP-Seq_VCAP_Human3.08094685
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.98666298
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.58383723
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41673396
9E2F7_22180533_ChIP-Seq_HELA_Human2.27222903
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26786033
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.23921617
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20024548
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16712638
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01934408
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98343365
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98098505
17E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.94671685
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86428600
19ZNF274_21170338_ChIP-Seq_K562_Hela1.84143386
20CTNNB1_20460455_ChIP-Seq_HCT116_Human1.79691890
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.71803840
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70602770
23BCAT_22108803_ChIP-Seq_LS180_Human1.65485183
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59325817
25FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56191608
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55017737
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52932902
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52739649
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.49578161
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47715709
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47027405
32FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46336538
33TBL1_22424771_ChIP-Seq_293T_Human1.45760428
34FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.45336229
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43681674
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42814787
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42479625
38AHR_22903824_ChIP-Seq_MCF-7_Human1.40719334
39VDR_22108803_ChIP-Seq_LS180_Human1.38059775
40KDM5A_27292631_Chip-Seq_BREAST_Human1.36621046
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.35997078
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.34998797
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.34964485
44STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34760667
45CBP_20019798_ChIP-Seq_JUKART_Human1.34431203
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34431203
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34130021
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34130021
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.33499411
50GBX2_23144817_ChIP-Seq_PC3_Human1.32466132
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30920009
52FUS_26573619_Chip-Seq_HEK293_Human1.30301211
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30174827
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30040266
55NFYB_21822215_ChIP-Seq_K562_Human1.29919989
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25634615
57CDX2_22108803_ChIP-Seq_LS180_Human1.24148627
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.23961694
59IRF1_19129219_ChIP-ChIP_H3396_Human1.23595187
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22293932
61NFYA_21822215_ChIP-Seq_K562_Human1.21920142
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20922081
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20922081
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.20838926
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20331008
66ER_23166858_ChIP-Seq_MCF-7_Human1.20138845
67EWS_26573619_Chip-Seq_HEK293_Human1.19081859
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18827459
69CHD1_26751641_Chip-Seq_LNCaP_Human1.18640947
70P300_19829295_ChIP-Seq_ESCs_Human1.17311893
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17263796
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.17195313
73RXR_22108803_ChIP-Seq_LS180_Human1.16918881
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16221005
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15979208
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.14897165
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14782217
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.14319425
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.10413760
80HNFA_21074721_ChIP-Seq_CACO-2_Human1.09859858
81GATA6_25053715_ChIP-Seq_YYC3_Human1.08226749
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07271906
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04910115
84CBP_21632823_ChIP-Seq_H3396_Human1.04726704
85CLOCK_20551151_ChIP-Seq_293T_Human1.04210204
86TP53_16413492_ChIP-PET_HCT116_Human1.03909810
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.02626540
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.01517568
89GATA6_21074721_ChIP-Seq_CACO-2_Human1.01481974
90ELK1_19687146_ChIP-ChIP_HELA_Human1.01322100
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00131484
92PHF8_20622853_ChIP-Seq_HELA_Human1.00006848
93TCF4_23295773_ChIP-Seq_U87_Human0.99142070
94CJUN_26792858_Chip-Seq_BT549_Human0.99050682
95SMAD4_21799915_ChIP-Seq_A2780_Human0.98984774
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97707827
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97563012
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97351740
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.97214838
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96987493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005408_hypopigmentation7.29895810
2MP0000372_irregular_coat_pigmentation4.86012335
3MP0003806_abnormal_nucleotide_metabolis4.51816206
4MP0005171_absent_coat_pigmentation4.50783147
5MP0003705_abnormal_hypodermis_morpholog4.02357349
6MP0008057_abnormal_DNA_replication3.88695324
7MP0002095_abnormal_skin_pigmentation3.04492865
8MP0000371_diluted_coat_color2.92398763
9MP0003136_yellow_coat_color2.90087457
10MP0000015_abnormal_ear_pigmentation2.87810377
11MP0003950_abnormal_plasma_membrane2.51972251
12MP0002877_abnormal_melanocyte_morpholog2.45672460
13MP0002234_abnormal_pharynx_morphology2.40564841
14MP0002938_white_spotting2.30492401
15MP0003718_maternal_effect2.11682802
16MP0002075_abnormal_coat/hair_pigmentati2.07096442
17MP0001186_pigmentation_phenotype1.99116201
18MP0000569_abnormal_digit_pigmentation1.98423317
19MP0005075_abnormal_melanosome_morpholog1.94999044
20MP0001324_abnormal_eye_pigmentation1.74476201
21MP0010094_abnormal_chromosome_stability1.70423688
22MP0004510_myositis1.66588582
23MP0005174_abnormal_tail_pigmentation1.62954187
24MP0001986_abnormal_taste_sensitivity1.60502252
25MP0002638_abnormal_pupillary_reflex1.52435319
26MP0003077_abnormal_cell_cycle1.45939257
27MP0004381_abnormal_hair_follicle1.39428007
28MP0000749_muscle_degeneration1.39061190
29MP0008058_abnormal_DNA_repair1.36310620
30MP0002102_abnormal_ear_morphology1.35905341
31MP0003111_abnormal_nucleus_morphology1.32894598
32MP0005167_abnormal_blood-brain_barrier1.30666794
33MP0003011_delayed_dark_adaptation1.30011285
34MP0004133_heterotaxia1.27599584
35MP0008932_abnormal_embryonic_tissue1.25052328
36MP0005377_hearing/vestibular/ear_phenot1.24979296
37MP0003878_abnormal_ear_physiology1.24979296
38MP0002090_abnormal_vision1.20078069
39MP0001485_abnormal_pinna_reflex1.17542278
40MP0010307_abnormal_tumor_latency1.13906034
41MP0005423_abnormal_somatic_nervous1.09831928
42MP0005395_other_phenotype1.09506560
43MP0004084_abnormal_cardiac_muscle1.09290645
44MP0000427_abnormal_hair_cycle1.08568071
45MP0005248_abnormal_Harderian_gland1.07847492
46MP0005551_abnormal_eye_electrophysiolog1.07844245
47MP0004883_abnormal_blood_vessel1.07221838
48MP0008789_abnormal_olfactory_epithelium1.06638105
49MP0005253_abnormal_eye_physiology1.06145267
50MP0004043_abnormal_pH_regulation1.01968585
51MP0001756_abnormal_urination1.00225741
52MP0005083_abnormal_biliary_tract0.98323427
53MP0008007_abnormal_cellular_replicative0.93708088
54MP0003693_abnormal_embryo_hatching0.93696680
55MP0003937_abnormal_limbs/digits/tail_de0.90073911
56MP0005257_abnormal_intraocular_pressure0.86149019
57MP0003880_abnormal_central_pattern0.83042451
58MP0005076_abnormal_cell_differentiation0.81905500
59MP0010368_abnormal_lymphatic_system0.81309032
60MP0005164_abnormal_response_to0.81024023
61MP0001299_abnormal_eye_distance/0.79487900
62MP0003941_abnormal_skin_development0.76268394
63MP0001666_abnormal_nutrient_absorption0.73647665
64MP0003045_fibrosis0.73554456
65MP0005621_abnormal_cell_physiology0.72870000
66MP0004272_abnormal_basement_membrane0.71269258
67MP0002909_abnormal_adrenal_gland0.70979952
68MP0005023_abnormal_wound_healing0.69706355
69MP0003786_premature_aging0.69228502
70MP0002653_abnormal_ependyma_morphology0.68563181
71MP0005220_abnormal_exocrine_pancreas0.68220025
72MP0002697_abnormal_eye_size0.66955966
73MP0010329_abnormal_lipoprotein_level0.66096452
74MP0000383_abnormal_hair_follicle0.64980520
75MP0004957_abnormal_blastocyst_morpholog0.64390445
76MP0000230_abnormal_systemic_arterial0.64248162
77MP0001879_abnormal_lymphatic_vessel0.62279207
78MP0003828_pulmonary_edema0.59724788
79MP0003186_abnormal_redox_activity0.57695805
80MP0005360_urolithiasis0.57136710
81MP0004036_abnormal_muscle_relaxation0.56286383
82MP0005499_abnormal_olfactory_system0.55963241
83MP0005394_taste/olfaction_phenotype0.55963241
84MP0009703_decreased_birth_body0.55815095
85MP0003632_abnormal_nervous_system0.55207272
86MP0000367_abnormal_coat/_hair0.55031133
87MP0003935_abnormal_craniofacial_develop0.54945875
88MP0003566_abnormal_cell_adhesion0.54876209
89MP0000566_synostosis0.53564546
90MP0005266_abnormal_metabolism0.52500644
91MP0005376_homeostasis/metabolism_phenot0.50957901
92MP0006054_spinal_hemorrhage0.50351333
93MP0002177_abnormal_outer_ear0.50165780
94MP0002098_abnormal_vibrissa_morphology0.49649094
95MP0002111_abnormal_tail_morphology0.49420499
96MP0004885_abnormal_endolymph0.48923120
97MP0002168_other_aberrant_phenotype0.46942423
98MP0010678_abnormal_skin_adnexa0.46707771
99MP0000377_abnormal_hair_follicle0.46640818
100MP0010234_abnormal_vibrissa_follicle0.45656695

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)4.75620369
2Aplasia/Hypoplasia of the sacrum (HP:0008517)4.00454559
3Abnormal auditory evoked potentials (HP:0006958)4.00369408
4Hypopigmentation of the fundus (HP:0007894)3.96997161
5Hypoplasia of the pons (HP:0012110)3.84848387
6Abnormality of the pons (HP:0007361)3.82393513
7Ocular albinism (HP:0001107)3.69218682
8Blue irides (HP:0000635)3.64138820
9Aplasia/Hypoplasia of the fovea (HP:0008060)3.48502347
10Hypoplasia of the fovea (HP:0007750)3.48502347
11Aplasia/Hypoplasia of the macula (HP:0008059)3.45485065
12Congenital sensorineural hearing impairment (HP:0008527)3.44838528
13Osteomalacia (HP:0002749)3.25288254
14Generalized hypopigmentation of hair (HP:0011358)3.23095272
15Aplasia/Hypoplasia affecting the retina (HP:0008061)3.20509729
16Iris hypopigmentation (HP:0007730)3.14735818
17Amelogenesis imperfecta (HP:0000705)3.09457545
18Abnormality of the nasal septum (HP:0000419)3.06296158
19Aplasia/Hypoplasia of the tibia (HP:0005772)3.05738825
20Rhabdomyosarcoma (HP:0002859)2.91124958
21Duplicated collecting system (HP:0000081)2.86688936
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83718857
23Depressed nasal tip (HP:0000437)2.82882846
24White forelock (HP:0002211)2.70542736
25Clubbing of toes (HP:0100760)2.67845640
26Astigmatism (HP:0000483)2.59311870
27Meckel diverticulum (HP:0002245)2.57607752
28Short tibia (HP:0005736)2.57417717
29Decreased central vision (HP:0007663)2.51946753
30Abnormality of the ileum (HP:0001549)2.51710085
31Abnormality of the parathyroid morphology (HP:0011766)2.49022441
32Thin ribs (HP:0000883)2.46993128
33Absent/shortened dynein arms (HP:0200106)2.46801376
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.46801376
35Lip pit (HP:0100267)2.46657132
36Patchy hypopigmentation of hair (HP:0011365)2.44660120
37Abnormality of the renal collecting system (HP:0004742)2.44347076
38Long foot (HP:0001833)2.43728885
39Long clavicles (HP:0000890)2.43452774
40Abnormality of the fovea (HP:0000493)2.42106134
41Chorioretinal atrophy (HP:0000533)2.37361943
42Pterygium (HP:0001059)2.34475112
43Vitreoretinal degeneration (HP:0000655)2.32810334
44Premature graying of hair (HP:0002216)2.31973650
45Generalized hypopigmentation (HP:0007513)2.29825260
46Irregular epiphyses (HP:0010582)2.27184578
47Myelomeningocele (HP:0002475)2.23612340
48Intellectual disability, moderate (HP:0002342)2.22479850
49Amniotic constriction ring (HP:0009775)2.21171287
50Abnormality of placental membranes (HP:0011409)2.21171287
51Gaze-evoked nystagmus (HP:0000640)2.16243292
52Intestinal atresia (HP:0011100)2.16031723
53Abnormality of the fetal cardiovascular system (HP:0010948)2.13210696
54Abnormal umbilical cord blood vessels (HP:0011403)2.13210696
55Single umbilical artery (HP:0001195)2.13210696
56Anencephaly (HP:0002323)2.09209418
57Small hand (HP:0200055)2.08498252
58Freckling (HP:0001480)2.07826883
59Ectopic kidney (HP:0000086)2.06565342
60Drooling (HP:0002307)2.04839342
61Fibular hypoplasia (HP:0003038)2.04467063
62Enlarged kidneys (HP:0000105)1.99880224
63Chromsome breakage (HP:0040012)1.99549026
64Aplasia/Hypoplasia of the uvula (HP:0010293)1.98447985
65Absent radius (HP:0003974)1.97356323
66Retinal detachment (HP:0000541)1.94684415
67Pulmonary artery stenosis (HP:0004415)1.94468830
68Aortic aneurysm (HP:0004942)1.92109234
69Aplasia/Hypoplasia of the sternum (HP:0006714)1.92073354
70Type 2 muscle fiber atrophy (HP:0003554)1.91761780
71Poor head control (HP:0002421)1.91235464
72Aplasia/Hypoplasia of the fibula (HP:0006492)1.89964088
73Congenital stationary night blindness (HP:0007642)1.89917773
74Duodenal stenosis (HP:0100867)1.88161487
75Small intestinal stenosis (HP:0012848)1.88161487
76Aplasia of the musculature (HP:0100854)1.86774218
77Oral leukoplakia (HP:0002745)1.84141046
78Abnormality of the ischium (HP:0003174)1.83012385
79Aplasia involving forearm bones (HP:0009822)1.82650918
80Absent forearm bone (HP:0003953)1.82650918
81Abnormality of the preputium (HP:0100587)1.82531160
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80087591
83Oligohydramnios (HP:0001562)1.78828691
84Abnormality of the duodenum (HP:0002246)1.78221856
85Excessive salivation (HP:0003781)1.78058094
86Leiomyosarcoma (HP:0100243)1.75236585
87Uterine leiomyosarcoma (HP:0002891)1.75236585
88Birth length less than 3rd percentile (HP:0003561)1.74956187
89Horseshoe kidney (HP:0000085)1.74673678
90Weak cry (HP:0001612)1.73828552
91Abnormality of the umbilical cord (HP:0010881)1.73361035
92Abnormality of the axillary hair (HP:0100134)1.71873942
93Abnormality of secondary sexual hair (HP:0009888)1.71873942
94Neoplasm of striated muscle (HP:0009728)1.71812573
95Hepatoblastoma (HP:0002884)1.70786656
96Transposition of the great arteries (HP:0001669)1.69219881
97Abnormal connection of the cardiac segments (HP:0011545)1.69219881
98Abnormal ventriculo-arterial connection (HP:0011563)1.69219881
99Abnormality of chromosome stability (HP:0003220)1.67893750
100Aqueductal stenosis (HP:0002410)1.66282754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.30265068
2PLK43.99479958
3FRK3.58682038
4AKT33.36145749
5WEE13.21073699
6PDK22.78727659
7PLK22.66749405
8BRSK22.54268364
9MKNK22.34454303
10OBSCN2.25948629
11SRPK12.16872853
12CAMK1D2.04452668
13LATS11.91450504
14CDC71.77241114
15TNIK1.60844140
16STK381.60544819
17PKN21.55793792
18TAF11.55736590
19BUB11.54438057
20NEK21.47872666
21EIF2AK31.46560865
22SGK21.43264073
23MKNK11.42453796
24PAK31.42408418
25BMPR1B1.37676817
26ACVR1B1.37418893
27BRD41.37195140
28CAMK1G1.31471646
29STK38L1.29261330
30NME11.27324148
31TTK1.21995386
32PRKAA21.20047296
33MYLK1.17053560
34MELK1.08328207
35ZAK1.06501886
36PLK31.05667754
37MAP3K71.03309250
38NLK1.03280007
39MARK31.02577788
40STK30.99305675
41STK390.98894681
42STK100.96663478
43PBK0.96495408
44CDK120.90283035
45YES10.87108606
46LIMK10.86620600
47SGK2230.85958622
48SGK4940.85958622
49FGFR10.85292045
50LATS20.82117172
51BRSK10.79078559
52ATR0.78484487
53CDK40.78020474
54IRAK20.76584373
55GSK3A0.74981857
56CHEK20.74578187
57ERBB30.74528111
58PLK10.73885964
59CSNK1G10.72691288
60FER0.71300189
61EIF2AK20.69632443
62UHMK10.67776020
63CSNK1A1L0.67450692
64PTK2B0.66533315
65EPHA40.66227717
66ADRBK10.65683884
67TAOK30.64163751
68WNK10.63198526
69DYRK1A0.62666765
70NEK60.62377035
71VRK10.62303839
72CDC42BPA0.59781623
73MAP2K60.57483882
74AKT10.56405038
75STK110.55878407
76AURKB0.55449290
77AURKA0.54571406
78PRKCH0.52406977
79MAP3K40.49066074
80PTK20.48957256
81PTK60.48492257
82CDK80.47863059
83SGK30.47815523
84ERBB20.47675620
85STK40.47524872
86CHUK0.43410604
87OXSR10.42658290
88VRK20.42600659
89NUAK10.42581990
90MTOR0.41314392
91CDK10.40984821
92ERBB40.39355244
93PDGFRB0.38997901
94MAP3K30.37567145
95SGK10.36474017
96PRKAA10.35403303
97MINK10.34120577
98EGFR0.34095859
99IRAK10.33896469
100TGFBR10.32816334

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.55210456
2Fanconi anemia pathway_Homo sapiens_hsa034603.27987354
3Homologous recombination_Homo sapiens_hsa034403.15551039
4Protein export_Homo sapiens_hsa030602.53774149
5RNA polymerase_Homo sapiens_hsa030202.41906414
6Circadian rhythm_Homo sapiens_hsa047102.41036634
7Lysine degradation_Homo sapiens_hsa003102.21642281
8Propanoate metabolism_Homo sapiens_hsa006401.99092921
9Butanoate metabolism_Homo sapiens_hsa006501.96218490
10Steroid biosynthesis_Homo sapiens_hsa001001.95936063
11One carbon pool by folate_Homo sapiens_hsa006701.94400733
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87254025
13Adherens junction_Homo sapiens_hsa045201.81657516
14beta-Alanine metabolism_Homo sapiens_hsa004101.76256667
15Histidine metabolism_Homo sapiens_hsa003401.61679439
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60745574
17Thyroid hormone synthesis_Homo sapiens_hsa049181.58915745
18Cell cycle_Homo sapiens_hsa041101.57030482
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54642852
20Prostate cancer_Homo sapiens_hsa052151.49504273
21Proteasome_Homo sapiens_hsa030501.38747294
22DNA replication_Homo sapiens_hsa030301.38052632
23TGF-beta signaling pathway_Homo sapiens_hsa043501.32651120
24Mismatch repair_Homo sapiens_hsa034301.30828491
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27489259
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27173790
27Non-homologous end-joining_Homo sapiens_hsa034501.26614466
28Tryptophan metabolism_Homo sapiens_hsa003801.25957042
29Fructose and mannose metabolism_Homo sapiens_hsa000511.24511239
30Pyrimidine metabolism_Homo sapiens_hsa002401.23629880
31MicroRNAs in cancer_Homo sapiens_hsa052061.21378696
32p53 signaling pathway_Homo sapiens_hsa041151.20997643
33Base excision repair_Homo sapiens_hsa034101.16542501
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13123838
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08490250
36Tyrosine metabolism_Homo sapiens_hsa003500.99463472
37Inositol phosphate metabolism_Homo sapiens_hsa005620.93833213
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90945706
39Pyruvate metabolism_Homo sapiens_hsa006200.89673308
40Sulfur relay system_Homo sapiens_hsa041220.88170554
41Folate biosynthesis_Homo sapiens_hsa007900.86396942
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86298302
43Hippo signaling pathway_Homo sapiens_hsa043900.84841746
44Linoleic acid metabolism_Homo sapiens_hsa005910.84128371
45Olfactory transduction_Homo sapiens_hsa047400.82214687
46Small cell lung cancer_Homo sapiens_hsa052220.82195442
47Arginine and proline metabolism_Homo sapiens_hsa003300.80477248
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.80369053
49Mineral absorption_Homo sapiens_hsa049780.79144495
50Ovarian steroidogenesis_Homo sapiens_hsa049130.78880380
51Insulin resistance_Homo sapiens_hsa049310.78702661
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77579935
53Arachidonic acid metabolism_Homo sapiens_hsa005900.77229301
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76433884
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72559326
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72515410
57ABC transporters_Homo sapiens_hsa020100.71726249
58Melanogenesis_Homo sapiens_hsa049160.70680716
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69825204
60Fatty acid degradation_Homo sapiens_hsa000710.69042307
61Taste transduction_Homo sapiens_hsa047420.68699068
62Nitrogen metabolism_Homo sapiens_hsa009100.68483127
63Purine metabolism_Homo sapiens_hsa002300.66609520
64Peroxisome_Homo sapiens_hsa041460.65382073
65Huntingtons disease_Homo sapiens_hsa050160.62578483
66N-Glycan biosynthesis_Homo sapiens_hsa005100.61525909
67Tight junction_Homo sapiens_hsa045300.60228685
68FoxO signaling pathway_Homo sapiens_hsa040680.59445662
69Glucagon signaling pathway_Homo sapiens_hsa049220.53916310
70AMPK signaling pathway_Homo sapiens_hsa041520.50890306
71Metabolic pathways_Homo sapiens_hsa011000.50361218
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.49876481
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46124068
74RNA transport_Homo sapiens_hsa030130.44991476
75Colorectal cancer_Homo sapiens_hsa052100.43377103
76Fatty acid biosynthesis_Homo sapiens_hsa000610.41407922
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41387858
78Fatty acid metabolism_Homo sapiens_hsa012120.41275348
79Retinol metabolism_Homo sapiens_hsa008300.40986000
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38635545
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37041000
82Salivary secretion_Homo sapiens_hsa049700.36703938
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36639453
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36300693
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36103707
86Pathways in cancer_Homo sapiens_hsa052000.34029019
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.33434780
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31515904
89Wnt signaling pathway_Homo sapiens_hsa043100.30930630
90Oocyte meiosis_Homo sapiens_hsa041140.30329570
91Bile secretion_Homo sapiens_hsa049760.30173277
92Nucleotide excision repair_Homo sapiens_hsa034200.28896233
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28119585
94Vibrio cholerae infection_Homo sapiens_hsa051100.27971035
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27797224
96Ether lipid metabolism_Homo sapiens_hsa005650.27523818
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27159934
98Glutathione metabolism_Homo sapiens_hsa004800.26539763
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23943574
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22221032

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