ATG13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal complex assembly (GO:0007172)4.24234963
2regulation of plasminogen activation (GO:0010755)4.16901308
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01649030
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.00544644
5L-phenylalanine catabolic process (GO:0006559)4.00544644
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.95487158
7synaptic vesicle maturation (GO:0016188)3.92214054
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.83973213
9L-phenylalanine metabolic process (GO:0006558)3.83973213
10neuromuscular process controlling posture (GO:0050884)3.64871836
11homocysteine metabolic process (GO:0050667)3.63655865
12negative regulation of cell killing (GO:0031342)3.52070188
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52070188
14COPII vesicle coating (GO:0048208)3.48968418
15glutamate secretion (GO:0014047)3.43423019
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36821565
17desmosome organization (GO:0002934)3.32004590
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26633083
19negative regulation of cell size (GO:0045792)3.26057939
20neuronal action potential propagation (GO:0019227)3.22765648
21aromatic amino acid family catabolic process (GO:0009074)3.21658123
22retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.21348124
23kynurenine metabolic process (GO:0070189)3.20583880
24amino acid import (GO:0043090)3.20298407
25RNA localization (GO:0006403)3.17766018
26microtubule nucleation (GO:0007020)3.16290835
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15634051
28positive regulation of nuclease activity (GO:0032075)3.15281045
29white fat cell differentiation (GO:0050872)3.13847397
30regulation of synaptic vesicle exocytosis (GO:2000300)3.13729296
31synaptic vesicle exocytosis (GO:0016079)3.13127666
32protein retention in ER lumen (GO:0006621)3.12836402
33peptidyl-proline hydroxylation (GO:0019511)3.10736265
34gamma-aminobutyric acid transport (GO:0015812)3.03190914
35positive regulation of protein dephosphorylation (GO:0035307)3.01445907
36macroautophagy (GO:0016236)3.01426916
37transferrin transport (GO:0033572)3.00727457
382-oxoglutarate metabolic process (GO:0006103)2.98999570
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97762254
40activation of protein kinase A activity (GO:0034199)2.96730999
41regulation of synaptic vesicle transport (GO:1902803)2.94981898
42cell communication by electrical coupling (GO:0010644)2.94554383
43cysteine metabolic process (GO:0006534)2.93790381
44dicarboxylic acid catabolic process (GO:0043649)2.92932522
45neurotransmitter secretion (GO:0007269)2.90981070
46dicarboxylic acid biosynthetic process (GO:0043650)2.89629441
47endoplasmic reticulum unfolded protein response (GO:0030968)2.89598211
48aspartate family amino acid catabolic process (GO:0009068)2.89269390
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.89012918
50synaptic vesicle docking involved in exocytosis (GO:0016081)2.88830941
51vesicle coating (GO:0006901)2.87562776
52serine family amino acid catabolic process (GO:0009071)2.86492294
53carnitine shuttle (GO:0006853)2.86292715
54regulation of cholesterol homeostasis (GO:2000188)2.84825830
55detection of calcium ion (GO:0005513)2.84014957
56locomotory exploration behavior (GO:0035641)2.83931231
57regulation of cholesterol storage (GO:0010885)2.83696211
58Golgi transport vesicle coating (GO:0048200)2.83204207
59COPI coating of Golgi vesicle (GO:0048205)2.83204207
60NADH metabolic process (GO:0006734)2.82847573
61biotin metabolic process (GO:0006768)2.81089528
62L-amino acid import (GO:0043092)2.80892070
63protein localization to endosome (GO:0036010)2.80217768
64cellular response to unfolded protein (GO:0034620)2.78679458
65chemosensory behavior (GO:0007635)2.78004739
66negative regulation of catenin import into nucleus (GO:0035414)2.77953084
67glutamate metabolic process (GO:0006536)2.77586503
68regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.76807031
69trivalent inorganic cation transport (GO:0072512)2.75929655
70ferric iron transport (GO:0015682)2.75929655
71lysine metabolic process (GO:0006553)2.75871862
72lysine catabolic process (GO:0006554)2.75871862
73regulation of nuclease activity (GO:0032069)2.74592869
74indole-containing compound catabolic process (GO:0042436)2.72635116
75indolalkylamine catabolic process (GO:0046218)2.72635116
76tryptophan catabolic process (GO:0006569)2.72635116
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.72031670
78barbed-end actin filament capping (GO:0051016)2.72002180
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.70268409
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68513271
81cellular modified amino acid catabolic process (GO:0042219)2.67388719
82cell communication involved in cardiac conduction (GO:0086065)2.66847094
83sodium ion export (GO:0071436)2.66025443
84fatty acid transmembrane transport (GO:1902001)2.64638047
85alpha-amino acid catabolic process (GO:1901606)2.63868838
86cellular response to topologically incorrect protein (GO:0035967)2.62833138
87tryptophan metabolic process (GO:0006568)2.62008991
88regulation of neuronal synaptic plasticity (GO:0048168)2.61479437
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.60397259
90response to pheromone (GO:0019236)2.60390739
91cellular amino acid catabolic process (GO:0009063)2.60324298
92ER-nucleus signaling pathway (GO:0006984)2.59882125
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.57975593
94fructose metabolic process (GO:0006000)2.55732906
95vocalization behavior (GO:0071625)2.54300674
96alpha-linolenic acid metabolic process (GO:0036109)2.53520068
97modulation by virus of host process (GO:0019054)2.53285454
98sulfur amino acid catabolic process (GO:0000098)2.51301121
99modulation by symbiont of host cellular process (GO:0044068)2.49636055
100cellular potassium ion homeostasis (GO:0030007)2.49314326
101negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.48818258
102regulation of synapse structural plasticity (GO:0051823)2.48496278
103histone H4-K12 acetylation (GO:0043983)2.48375946
104mannose metabolic process (GO:0006013)2.47802314
105cellular ketone body metabolic process (GO:0046950)2.47568699
106aromatic amino acid family metabolic process (GO:0009072)2.47044611
107glycine transport (GO:0015816)2.46496235
108negative regulation of blood vessel endothelial cell migration (GO:0043537)2.46088786
109fatty acid homeostasis (GO:0055089)2.45805386
110response to lipoprotein particle (GO:0055094)2.45756418
111oxaloacetate metabolic process (GO:0006107)2.45457184
112vesicle targeting (GO:0006903)2.45115376
113regulation of gamma-delta T cell differentiation (GO:0045586)2.44885479
114growth hormone secretion (GO:0030252)2.44877537
115branched-chain amino acid catabolic process (GO:0009083)2.44863281
116bile acid biosynthetic process (GO:0006699)2.44769282
117creatine metabolic process (GO:0006600)2.42678328
118antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42158788
119regulation of regulated secretory pathway (GO:1903305)2.41501270
120CDP-diacylglycerol metabolic process (GO:0046341)2.41430110
121amino-acid betaine metabolic process (GO:0006577)2.41406972
122protein-chromophore linkage (GO:0018298)2.41210516
123endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40952918
124cell migration in hindbrain (GO:0021535)2.40740270
125negative regulation of erythrocyte differentiation (GO:0045647)2.40513329
126mitochondrion degradation (GO:0000422)2.40422810
127regulation of autophagic vacuole assembly (GO:2000785)2.39578050
128positive regulation of synapse maturation (GO:0090129)2.39416373
129regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39339775
130glyoxylate metabolic process (GO:0046487)2.38063707
131G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.37256372
132long-term memory (GO:0007616)2.37041718
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35514392
134coenzyme catabolic process (GO:0009109)2.35435753
135regulation of ARF protein signal transduction (GO:0032012)2.34905230
136positive regulation of membrane potential (GO:0045838)2.34819908
137neuromuscular process controlling balance (GO:0050885)2.34634083
138positive regulation of protein homooligomerization (GO:0032464)2.34467906
139membrane depolarization during action potential (GO:0086010)2.34354519
140sarcoplasmic reticulum calcium ion transport (GO:0070296)2.33994162
141response to parathyroid hormone (GO:0071107)2.33039504
142primary amino compound metabolic process (GO:1901160)2.32806706
143short-chain fatty acid metabolic process (GO:0046459)2.32221180
144regulation of glutamate receptor signaling pathway (GO:1900449)2.32091725
145neurotransmitter transport (GO:0006836)2.31656674
146protein hydroxylation (GO:0018126)2.31636576
147triglyceride homeostasis (GO:0070328)2.31237966
148acylglycerol homeostasis (GO:0055090)2.31237966
149regulation of bile acid biosynthetic process (GO:0070857)2.30597866
150* autophagic vacuole assembly (GO:0000045)2.30516347
151positive regulation of sodium ion transport (GO:0010765)2.30487445
152L-serine metabolic process (GO:0006563)2.30255194
153intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.29858321
154protein targeting to plasma membrane (GO:0072661)2.29613325
155regulation of sodium ion transmembrane transporter activity (GO:2000649)2.29569631
156regulation of defense response to virus by virus (GO:0050690)2.29479311
157carboxylic acid catabolic process (GO:0046395)2.29306696
158organic acid catabolic process (GO:0016054)2.29306696
159cerebellar Purkinje cell layer development (GO:0021680)2.28605894
160phosphatidylglycerol biosynthetic process (GO:0006655)2.28251003
161triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.27212708
162regulation of neurotransmitter levels (GO:0001505)2.26974785
163bile acid metabolic process (GO:0008206)2.26640423
1644-hydroxyproline metabolic process (GO:0019471)2.26533168
165response to endoplasmic reticulum stress (GO:0034976)2.26216789
166fatty acid beta-oxidation (GO:0006635)2.25185862
167cerebellar granule cell differentiation (GO:0021707)2.24481136
168positive regulation of pseudopodium assembly (GO:0031274)2.24270139
169negative regulation of innate immune response (GO:0045824)2.24134756
170protein insertion into membrane (GO:0051205)2.24089685
171neuronal ion channel clustering (GO:0045161)2.23618423
172regulation of gamma-delta T cell activation (GO:0046643)2.22854595
173regulation of protein dephosphorylation (GO:0035304)2.22854494
174innervation (GO:0060384)2.22161630
175megakaryocyte development (GO:0035855)2.21117185
176regulation of tight junction assembly (GO:2000810)2.17341251
177negative regulation of viral release from host cell (GO:1902187)2.16822432
178regulation of superoxide anion generation (GO:0032928)2.16536063
179regulation of leukocyte degranulation (GO:0043300)2.16253824
180RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.14340993
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.14340993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.08754311
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.14033351
3PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77410996
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.64481617
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.52559363
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.44480870
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40115756
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36977247
9REST_18959480_ChIP-ChIP_MESCs_Mouse2.33563654
10REST_21632747_ChIP-Seq_MESCs_Mouse2.28732408
11EZH2_22144423_ChIP-Seq_EOC_Human2.23039347
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19242055
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.18183800
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17092442
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.13345330
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13240124
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08557009
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.05270505
19DROSHA_22980978_ChIP-Seq_HELA_Human2.04326311
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98216892
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94699913
22KDM2B_26808549_Chip-Seq_DND41_Human1.92864672
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90589856
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82133686
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82039715
26TCF7_22412390_ChIP-Seq_EML_Mouse1.81132207
27MYC_22102868_ChIP-Seq_BL_Human1.78533651
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77855090
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74246970
30CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67530976
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.66534103
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65844327
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64312255
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63755585
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63529987
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63372610
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60720915
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59814419
39CTCF_27219007_Chip-Seq_Bcells_Human1.59807601
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.57383684
41VDR_21846776_ChIP-Seq_THP-1_Human1.57003946
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56780188
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47816381
44KDM2B_26808549_Chip-Seq_K562_Human1.47203703
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44726906
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43415591
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42861572
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42800069
49LXR_22292898_ChIP-Seq_THP-1_Human1.42699308
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42662732
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42519165
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42399770
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42088671
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.41222042
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40105489
56SMC4_20622854_ChIP-Seq_HELA_Human1.39259762
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.38874006
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36161879
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35923508
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35726071
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34748300
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34323731
63P68_20966046_ChIP-Seq_HELA_Human1.33668294
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32220606
65ZNF263_19887448_ChIP-Seq_K562_Human1.32076848
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.31592206
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30613499
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.29813297
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29440558
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29351817
71NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28679423
72TP53_22127205_ChIP-Seq_IMR90_Human1.28310163
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27976036
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.27806525
75TET1_21490601_ChIP-Seq_MESCs_Mouse1.27800973
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26742823
77UTX_26944678_Chip-Seq_JUKART_Human1.25558017
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25009135
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24126764
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23754626
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23487328
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23245010
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23245010
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22396210
85GATA1_19941826_ChIP-Seq_K562_Human1.21591469
86STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20265413
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19963349
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19506152
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19030601
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18579803
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18126494
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.17463554
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.17384907
94KLF4_19829295_ChIP-Seq_ESCs_Human1.17223869
95NCOR1_26117541_ChIP-Seq_K562_Human1.17182852
96CREB1_26743006_Chip-Seq_LNCaP_Human1.16764701
97MAF_26560356_Chip-Seq_TH2_Human1.16148730
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15852487
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15067091
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14893058
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.14841470
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14482153
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12797913
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.11949502
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10896423
106SPI1_23127762_ChIP-Seq_K562_Human1.10338890
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09784300
108STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09761567
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.09658260
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09051221
111FOXA2_19822575_ChIP-Seq_HepG2_Human1.06976150
112ATF3_27146783_Chip-Seq_COLON_Human1.06841830
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06265631
114MAF_26560356_Chip-Seq_TH1_Human1.04585805
115SA1_27219007_Chip-Seq_Bcells_Human1.04547682
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04280713
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03509316
118RNF2_27304074_Chip-Seq_ESCs_Mouse1.03451001
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00166390
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98978559
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98748730
122RACK7_27058665_Chip-Seq_MCF-7_Human0.98407288
123FOXH1_21741376_ChIP-Seq_ESCs_Human0.98386331
124OCT4_19829295_ChIP-Seq_ESCs_Human0.98363766
125PHF8_20622854_ChIP-Seq_HELA_Human0.98288614
126* TP63_22573176_ChIP-Seq_HFKS_Human0.97874879
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96868428
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95873462
129GBX2_23144817_ChIP-Seq_PC3_Human0.93941824
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93923199
131EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93655297
132P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93343645
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91187868
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90901995
135E2F1_20622854_ChIP-Seq_HELA_Human0.90781280
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88811805
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88677431
138BCOR_27268052_Chip-Seq_Bcells_Human0.87542954
139EZH2_27304074_Chip-Seq_ESCs_Mouse0.87355622
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.85518485
141SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84568972
142TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83584434
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82567166
144SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81998727
145AHR_22903824_ChIP-Seq_MCF-7_Human0.81203519
146AR_19668381_ChIP-Seq_PC3_Human0.81039421
147GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80636162
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80398130
149ERA_21632823_ChIP-Seq_H3396_Human0.79762215
150OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.79547015
151JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.79175810
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78967060
153ZFP281_27345836_Chip-Seq_ESCs_Mouse0.78041204
154BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77819960
155RARA_24833708_ChIP-Seq_LIVER_Mouse0.77803591
156CTCF_20526341_ChIP-Seq_ESCs_Human0.77759536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.88593963
2MP0003705_abnormal_hypodermis_morpholog3.70981230
3MP0002139_abnormal_hepatobiliary_system3.64444602
4MP0005365_abnormal_bile_salt3.21650478
5MP0005085_abnormal_gallbladder_physiolo3.05274863
6MP0003724_increased_susceptibility_to2.86332811
7MP0004270_analgesia2.80534703
8MP0002822_catalepsy2.76093212
9MP0002837_dystrophic_cardiac_calcinosis2.70963158
10MP0009840_abnormal_foam_cell2.60078587
11MP0002909_abnormal_adrenal_gland2.58454495
12MP0003436_decreased_susceptibility_to2.47597753
13MP0005360_urolithiasis2.43530323
14MP0003195_calcinosis2.40035306
15MP0003635_abnormal_synaptic_transmissio2.36342316
16MP0004043_abnormal_pH_regulation2.09907740
17MP0005423_abnormal_somatic_nervous2.07491933
18MP0002064_seizures2.01308066
19MP0005083_abnormal_biliary_tract1.95398307
20MP0000920_abnormal_myelination1.93135816
21MP0003806_abnormal_nucleotide_metabolis1.89189436
22MP0003329_amyloid_beta_deposits1.84894606
23MP0009745_abnormal_behavioral_response1.79369381
24MP0003300_gastrointestinal_ulcer1.78100419
25MP0009046_muscle_twitch1.76740535
26MP0002063_abnormal_learning/memory/cond1.75425994
27MP0001533_abnormal_skeleton_physiology1.72845004
28MP0003880_abnormal_central_pattern1.71013315
29MP0002272_abnormal_nervous_system1.68938397
30MP0002653_abnormal_ependyma_morphology1.65037243
31MP0004510_myositis1.64835176
32MP0010329_abnormal_lipoprotein_level1.64735537
33MP0002132_abnormal_respiratory_system1.63759219
34MP0005332_abnormal_amino_acid1.62635477
35MP0001666_abnormal_nutrient_absorption1.60667717
36MP0005646_abnormal_pituitary_gland1.59006829
37MP0003879_abnormal_hair_cell1.58113786
38MP0002254_reproductive_system_inflammat1.57738815
39MP0008875_abnormal_xenobiotic_pharmacok1.54554313
40MP0003183_abnormal_peptide_metabolism1.54161045
41MP0003075_altered_response_to1.52136972
42MP0002734_abnormal_mechanical_nocicepti1.46641256
43MP0004947_skin_inflammation1.46273652
44MP0002572_abnormal_emotion/affect_behav1.45311494
45MP0002736_abnormal_nociception_after1.43026906
46MP0002118_abnormal_lipid_homeostasis1.42727400
47MP0009780_abnormal_chondrocyte_physiolo1.41820955
48MP0002733_abnormal_thermal_nociception1.39415736
49MP0001661_extended_life_span1.38280282
50MP0003283_abnormal_digestive_organ1.37723166
51MP0000747_muscle_weakness1.37671018
52MP0003252_abnormal_bile_duct1.36642755
53MP0001501_abnormal_sleep_pattern1.36545663
54MP0008260_abnormal_autophagy1.36414795
55MP0002295_abnormal_pulmonary_circulatio1.36127189
56MP0004145_abnormal_muscle_electrophysio1.35577898
57MP0001486_abnormal_startle_reflex1.35445103
58MP0005670_abnormal_white_adipose1.35272217
59MP0004233_abnormal_muscle_weight1.34421764
60MP0002078_abnormal_glucose_homeostasis1.34095468
61MP0003172_abnormal_lysosome_physiology1.33907975
62MP0002735_abnormal_chemical_nociception1.33489667
63MP0003646_muscle_fatigue1.32875090
64MP0008961_abnormal_basal_metabolism1.32793782
65MP0004885_abnormal_endolymph1.31658599
66MP0008995_early_reproductive_senescence1.31532896
67MP0005058_abnormal_lysosome_morphology1.31522722
68MP0000751_myopathy1.31028710
69MP0002089_abnormal_postnatal_growth/wei1.29672618
70MP0004858_abnormal_nervous_system1.25959941
71MP0001968_abnormal_touch/_nociception1.25674942
72MP0009278_abnormal_bone_marrow1.25439665
73MP0003634_abnormal_glial_cell1.24399553
74MP0003191_abnormal_cellular_cholesterol1.24343441
75MP0002693_abnormal_pancreas_physiology1.23019632
76MP0004036_abnormal_muscle_relaxation1.22886025
77MP0005535_abnormal_body_temperature1.22785811
78MP0001970_abnormal_pain_threshold1.22678828
79MP0002269_muscular_atrophy1.22362690
80MP0008569_lethality_at_weaning1.20958912
81MP0001440_abnormal_grooming_behavior1.20958071
82MP0002229_neurodegeneration1.19863608
83MP0004147_increased_porphyrin_level1.17878315
84MP0000013_abnormal_adipose_tissue1.17500042
85MP0004185_abnormal_adipocyte_glucose1.16281954
86MP0000604_amyloidosis1.16270157
87MP0010386_abnormal_urinary_bladder1.15398877
88MP0003868_abnormal_feces_composition1.14979084
89MP0001502_abnormal_circadian_rhythm1.14666723
90MP0004130_abnormal_muscle_cell1.12444085
91MP0001944_abnormal_pancreas_morphology1.11655889
92MP0002067_abnormal_sensory_capabilities1.11392318
93MP0005645_abnormal_hypothalamus_physiol1.09358430
94MP0005076_abnormal_cell_differentiation1.06851797
95MP0003690_abnormal_glial_cell1.06794191
96MP0004924_abnormal_behavior1.06210636
97MP0005386_behavior/neurological_phenoty1.06210636
98MP0000955_abnormal_spinal_cord1.02570979
99MP0002138_abnormal_hepatobiliary_system1.02291286
100MP0005451_abnormal_body_composition1.01883204
101MP0003566_abnormal_cell_adhesion1.01350783
102MP0000749_muscle_degeneration1.00313098
103MP0004381_abnormal_hair_follicle0.99293035
104MP0002066_abnormal_motor_capabilities/c0.98892522
105MP0003953_abnormal_hormone_level0.96880682
106MP0003137_abnormal_impulse_conducting0.96815615
107MP0000858_altered_metastatic_potential0.96620539
108MP0005319_abnormal_enzyme/_coenzyme0.95803236
109MP0004084_abnormal_cardiac_muscle0.95146043
110MP0004019_abnormal_vitamin_homeostasis0.94675600
111MP0003656_abnormal_erythrocyte_physiolo0.94480533
112MP0009333_abnormal_splenocyte_physiolog0.94202754
113MP0000003_abnormal_adipose_tissue0.93719319
114MP0006036_abnormal_mitochondrial_physio0.93474124
115MP0003123_paternal_imprinting0.93322048
116MP0003633_abnormal_nervous_system0.93313385
117MP0001851_eye_inflammation0.93304498
118MP0004085_abnormal_heartbeat0.93301079
119MP0004811_abnormal_neuron_physiology0.92333717
120MP0002069_abnormal_eating/drinking_beha0.92325359
121MP0000609_abnormal_liver_physiology0.92082487
122MP0008874_decreased_physiological_sensi0.89171655
123MP0005220_abnormal_exocrine_pancreas0.85400765
124MP0005330_cardiomyopathy0.84097032
125MP0001765_abnormal_ion_homeostasis0.84031879
126MP0005390_skeleton_phenotype0.82677144
127MP0009643_abnormal_urine_homeostasis0.82495037
128MP0004215_abnormal_myocardial_fiber0.81663139
129MP0001756_abnormal_urination0.80891564
130MP0002419_abnormal_innate_immunity0.80269225
131MP0003631_nervous_system_phenotype0.80177884
132MP0002184_abnormal_innervation0.79647019
133MP0005000_abnormal_immune_tolerance0.79557952
134MP0001348_abnormal_lacrimal_gland0.78425698
135MP0002998_abnormal_bone_remodeling0.77785407
136MP0004264_abnormal_extraembryonic_tissu0.73802335
137MP0003763_abnormal_thymus_physiology0.72611071
138MP0003045_fibrosis0.69146315
139MP0001270_distended_abdomen0.67444193
140MP0005025_abnormal_response_to0.67411146
141MP0003279_aneurysm0.65652632
142MP0005164_abnormal_response_to0.65178641
143MP0005464_abnormal_platelet_physiology0.63615517
144MP0002971_abnormal_brown_adipose0.61374474
145MP0003795_abnormal_bone_structure0.60160721
146MP0001346_abnormal_lacrimal_gland0.58730618
147MP0002163_abnormal_gland_morphology0.58181324
148MP0000015_abnormal_ear_pigmentation0.56885861
149MP0002970_abnormal_white_adipose0.55887040
150MP0003303_peritoneal_inflammation0.55109237
151MP0005167_abnormal_blood-brain_barrier0.53370568
152MP0003866_abnormal_defecation0.53145898
153MP0002876_abnormal_thyroid_physiology0.53001056

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)3.95074005
2Hyperinsulinemic hypoglycemia (HP:0000825)3.84811012
3Gout (HP:0001997)3.84532864
4Hyperglycinemia (HP:0002154)3.69840147
5Focal motor seizures (HP:0011153)3.61682302
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55865541
7Myokymia (HP:0002411)3.55048050
8Hyperglycinuria (HP:0003108)3.54834793
9Hypoglycemic coma (HP:0001325)3.47695482
10Ketosis (HP:0001946)3.35621277
11Ketoacidosis (HP:0001993)3.35582557
12Bundle branch block (HP:0011710)3.27765256
13Abnormality of glycine metabolism (HP:0010895)3.16952573
14Abnormality of serine family amino acid metabolism (HP:0010894)3.16952573
15Visual hallucinations (HP:0002367)3.14216982
16Intrahepatic cholestasis (HP:0001406)3.11628667
17Esophageal varix (HP:0002040)3.11276241
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.93616515
19Hypoglycemic seizures (HP:0002173)2.91826434
20Hyperglycemia (HP:0003074)2.87844633
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.86225948
22Ventricular fibrillation (HP:0001663)2.83066151
23Atrioventricular block (HP:0001678)2.83034320
24Insomnia (HP:0100785)2.80773547
25Exercise-induced myalgia (HP:0003738)2.77891474
26Focal seizures (HP:0007359)2.75999972
27Loss of speech (HP:0002371)2.75229166
28Hyperammonemia (HP:0001987)2.72138680
29Biconcave vertebral bodies (HP:0004586)2.71222598
30Obstructive sleep apnea (HP:0002870)2.69622249
31Hypercortisolism (HP:0001578)2.63317425
32Abnormality of the lower motor neuron (HP:0002366)2.63186023
33Distal upper limb amyotrophy (HP:0007149)2.61720401
34Upper limb amyotrophy (HP:0009129)2.61720401
35Cerebral inclusion bodies (HP:0100314)2.60600945
36Hand muscle atrophy (HP:0009130)2.60046890
37Hyperlipoproteinemia (HP:0010980)2.59435493
38Abnormality of liposaccharide metabolism (HP:0010968)2.59247948
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.59247948
40Abnormality of glycolipid metabolism (HP:0010969)2.59247948
41Gastrointestinal dysmotility (HP:0002579)2.58122342
42Status epilepticus (HP:0002133)2.56081519
43Heart block (HP:0012722)2.55722821
44Supranuclear gaze palsy (HP:0000605)2.55392144
45Myocardial infarction (HP:0001658)2.54850886
46Ileus (HP:0002595)2.54263543
47Clonus (HP:0002169)2.51139749
48Xanthomatosis (HP:0000991)2.48735199
49Heterochromia iridis (HP:0001100)2.46501401
50Abnormal umbilical cord blood vessels (HP:0011403)2.46339974
51Single umbilical artery (HP:0001195)2.46339974
52Abnormality of the fetal cardiovascular system (HP:0010948)2.46339974
53Generalized tonic-clonic seizures (HP:0002069)2.45461049
54Symptomatic seizures (HP:0011145)2.45283760
55Epileptic encephalopathy (HP:0200134)2.44924199
56Abnormal social behavior (HP:0012433)2.39763250
57Impaired social interactions (HP:0000735)2.39763250
58Visceral angiomatosis (HP:0100761)2.38607142
59Anorexia (HP:0002039)2.36398533
60Testicular atrophy (HP:0000029)2.35813067
61Oligomenorrhea (HP:0000876)2.35361668
62Late onset (HP:0003584)2.32675395
63Abnormality of binocular vision (HP:0011514)2.32596477
64Diplopia (HP:0000651)2.32596477
65Deep venous thrombosis (HP:0002625)2.32119870
66Abnormal gallbladder physiology (HP:0012438)2.30291145
67Cholecystitis (HP:0001082)2.30291145
68Neurofibrillary tangles (HP:0002185)2.29934589
69Abnormal atrioventricular conduction (HP:0005150)2.29790001
70Growth hormone excess (HP:0000845)2.28531251
71Pheochromocytoma (HP:0002666)2.26381831
72Back pain (HP:0003418)2.26189582
73Insulin-resistant diabetes mellitus (HP:0000831)2.26140604
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25360840
75Poor eye contact (HP:0000817)2.21348456
76Peripheral hypomyelination (HP:0007182)2.21221656
77Sudden death (HP:0001699)2.20801671
78Neuronal loss in central nervous system (HP:0002529)2.17860345
79Myoglobinuria (HP:0002913)2.17016719
80Large for gestational age (HP:0001520)2.16688307
81Hyperparathyroidism (HP:0000843)2.16319209
82Slow saccadic eye movements (HP:0000514)2.15963928
83Polygenic inheritance (HP:0010982)2.14336791
84Tetraplegia (HP:0002445)2.14287620
85Abnormality of fatty-acid metabolism (HP:0004359)2.12900402
86Abnormality of the intrinsic pathway (HP:0010989)2.12749200
87EEG with generalized epileptiform discharges (HP:0011198)2.11604920
88Dysostosis multiplex (HP:0000943)2.10566790
89Complement deficiency (HP:0004431)2.09798022
90Absence seizures (HP:0002121)2.09727585
91Spinal canal stenosis (HP:0003416)2.09648757
92Vertebral compression fractures (HP:0002953)2.09636830
93Ankle clonus (HP:0011448)2.09162569
94Dialeptic seizures (HP:0011146)2.09108586
95Pulmonary embolism (HP:0002204)2.08912196
96Pustule (HP:0200039)2.07955700
97Epileptiform EEG discharges (HP:0011182)2.07922991
98Cerebral hypomyelination (HP:0006808)2.06126073
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.05480623
100Hypsarrhythmia (HP:0002521)2.04859571
101Syncope (HP:0001279)2.04012783
102Dicarboxylic aciduria (HP:0003215)2.02832249
103Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02832249
104Hemangiomatosis (HP:0007461)2.02031657
105Global brain atrophy (HP:0002283)2.01990682
106Abnormality of serum amino acid levels (HP:0003112)2.01647400
107Atonic seizures (HP:0010819)2.01141262
108Abnormal gallbladder morphology (HP:0012437)2.01105876
109Hyporeflexia of lower limbs (HP:0002600)2.01051014
110Myopathic facies (HP:0002058)1.99937225
111Postural instability (HP:0002172)1.99566184
112Fatigue (HP:0012378)1.99516295
113Progressive cerebellar ataxia (HP:0002073)1.99210668
114Febrile seizures (HP:0002373)1.97927706
115Action tremor (HP:0002345)1.97545472
116Conjugated hyperbilirubinemia (HP:0002908)1.95971728
117Myositis (HP:0100614)1.95534846
118Spastic gait (HP:0002064)1.94817471
119Prolonged partial thromboplastin time (HP:0003645)1.94246715
120Depression (HP:0000716)1.94177531
121Eczematoid dermatitis (HP:0000976)1.93830811
122Delusions (HP:0000746)1.93716461
123Ventricular arrhythmia (HP:0004308)1.93630704
124Hyperuricemia (HP:0002149)1.92908139
125Increased purine levels (HP:0004368)1.92908139
126Dysmetric saccades (HP:0000641)1.92800989
127Cholelithiasis (HP:0001081)1.92325653
128Abnormality of endocrine pancreas physiology (HP:0012093)1.90887815
129Abnormality of the pancreatic islet cells (HP:0006476)1.90887815
130Anxiety (HP:0000739)1.90745572
131Systemic lupus erythematosus (HP:0002725)1.90692476
132Neuroendocrine neoplasm (HP:0100634)1.89626615
133Irritability (HP:0000737)1.89527319
134Hypoalphalipoproteinemia (HP:0003233)1.89299689
135Palpitations (HP:0001962)1.88140045
136Abnormality of polysaccharide metabolism (HP:0011012)1.87928930
137Progressive muscle weakness (HP:0003323)1.87336577
138Skin nodule (HP:0200036)1.87154043
139Resting tremor (HP:0002322)1.87095289
140Abnormality of purine metabolism (HP:0004352)1.86672500
141Truncal ataxia (HP:0002078)1.86195731
142Hyperacusis (HP:0010780)1.85758433
143Small epiphyses (HP:0010585)1.85134096
144Abnormality of alanine metabolism (HP:0010916)1.84464677
145Hyperalaninemia (HP:0003348)1.84464677
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84464677
147Intention tremor (HP:0002080)1.84231689
148Death in childhood (HP:0003819)1.83857867
149Glomerulonephritis (HP:0000099)1.83549195
150Mitral stenosis (HP:0001718)1.83380570
151Dysmetria (HP:0001310)1.83085277
152Torticollis (HP:0000473)1.82960798
153Urinary bladder sphincter dysfunction (HP:0002839)1.82364805
154Generalized aminoaciduria (HP:0002909)1.82080457
155Gingival bleeding (HP:0000225)1.81760279
156Urinary glycosaminoglycan excretion (HP:0003541)1.81695041
157Mucopolysacchariduria (HP:0008155)1.81695041
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81458214
159Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81458214
160Hypercalciuria (HP:0002150)1.80856735
161Disproportionate tall stature (HP:0001519)1.80781591
162Poor speech (HP:0002465)1.79053710
163Microcytic anemia (HP:0001935)1.75382458
164Abnormality of the umbilical cord (HP:0010881)1.72628292
165Dementia (HP:0000726)1.72314098
166Urinary incontinence (HP:0000020)1.72068028
167Congenital sensorineural hearing impairment (HP:0008527)1.68259647
168Insulin resistance (HP:0000855)1.68211476
169Abnormality of alkaline phosphatase activity (HP:0004379)1.66492522
170Osteoarthritis (HP:0002758)1.66325674
171Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66036404
172Reticulocytosis (HP:0001923)1.65221963
173Hammertoe (HP:0001765)1.65033958
174Elevated alkaline phosphatase (HP:0003155)1.64979620
175White forelock (HP:0002211)1.64781593
176Recurrent abscess formation (HP:0002722)1.64351158
177Cortical visual impairment (HP:0100704)1.63575609
178Increased cerebral lipofuscin (HP:0011813)1.62621900
179Rigidity (HP:0002063)1.62570828
180Abnormality of the heme biosynthetic pathway (HP:0010472)1.62002851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.46081968
2AKT33.34302170
3LMTK23.03098847
4MAP3K92.94056663
5EPHA42.76369861
6BCKDK2.76208421
7PRPF4B2.70554088
8MAP3K32.37692585
9INSRR2.36337177
10ERN12.29129640
11PAK62.24923322
12MAP2K32.22696371
13NTRK12.20050122
14PINK12.08112182
15DAPK22.03794036
16RIPK41.94314021
17PRKD31.81134915
18KSR21.76163214
19STK381.72611391
20CAMKK21.72595966
21SMG11.69230412
22CAMKK11.68816261
23MAP2K41.65302932
24IRAK31.60331668
25SIK31.57979827
26MAP3K41.55551760
27PRKD21.51345068
28MAP4K11.51064863
29ICK1.49388717
30TESK11.46850127
31FGR1.46120613
32TAOK31.44319339
33SIK11.44258136
34PHKG21.42835699
35PHKG11.42835699
36ARAF1.42687439
37EPHA21.35296737
38MAP3K21.33622248
39LIMK11.33499733
40NEK11.33122404
41SGK2231.32652982
42SGK4941.32652982
43GRK61.26716490
44MAP3K11.24369610
45TAOK11.23805530
46SGK31.22382412
47MINK11.21847787
48DYRK1B1.19169362
49CDK91.16605673
50TRIB31.13036048
51GRK51.11835790
52CDC42BPA1.06027284
53MARK11.05768408
54FES1.05244138
55PDPK11.03069178
56SGK21.01643732
57CDK50.98924703
58ALK0.96702351
59PRKCG0.95357333
60PRKCI0.95284304
61EPHA30.95105424
62PRKCH0.94010793
63PAK30.93878215
64CAMK2G0.93873483
65FGFR40.93672708
66ZAP700.93586866
67NEK60.93155078
68JAK30.92234318
69PTK60.88288796
70TAOK20.87846637
71TYRO30.86680450
72CAMK10.86580033
73PDGFRA0.84024661
74IRAK20.83305743
75MAPK150.82867375
76CAMK2D0.80919256
77TESK20.79097815
78BRAF0.78241814
79PDK10.77255603
80DAPK10.76393470
81PRKAA10.74582054
82HIPK20.74154879
83SIK20.73998448
84RIPK10.73607097
85PNCK0.73281488
86PIM20.72629412
87CAMK40.71881513
88RET0.70412703
89WNK10.70238531
90WNK40.69566543
91PDK30.67691890
92PDK40.67691890
93UHMK10.66524355
94PRKG20.66419100
95MAP2K70.66405884
96IRAK40.66239189
97MAPK110.66221106
98CAMK2B0.66178095
99MAPKAPK30.65459689
100PAK40.65456517
101JAK20.62332771
102NTRK20.61849900
103TBK10.61060754
104CLK10.61058653
105BMPR20.61042732
106MTOR0.60499858
107EEF2K0.60319364
108STK110.60112894
109MARK20.59869830
110CAMK1G0.59199707
111CAMK2A0.57396150
112JAK10.56804386
113MAP3K110.55210806
114YES10.55165759
115KSR10.54762025
116PRKACG0.53956708
117BMX0.53941147
118PRKD10.53832144
119MAPK100.53088129
120FER0.52935515
121PKN10.52858677
122MAP2K10.52229749
123TNK20.52155937
124CDK120.51885170
125CDK190.51519506
126EPHB10.50148130
127DAPK30.49789883
128OXSR10.49558429
129CAMK1D0.48808969
130MAP3K70.47811017
131RPS6KA30.47618342
132SGK10.47274931
133MAPK70.46765845
134MAPKAPK20.44668318
135BRSK10.44606253
136MAP2K20.44300229
137PRKCZ0.42809313
138FLT30.42575508
139PTK20.42500363
140RPS6KA20.42007992
141MAPK120.40851601
142FYN0.39385107
143PRKCD0.35516904

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18142702
2Nitrogen metabolism_Homo sapiens_hsa009102.92560743
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.69044595
4Arginine biosynthesis_Homo sapiens_hsa002202.33683461
5Other glycan degradation_Homo sapiens_hsa005112.27357514
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.23532232
7Synaptic vesicle cycle_Homo sapiens_hsa047212.13428855
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11751464
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00139889
10Insulin secretion_Homo sapiens_hsa049111.89554111
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86843696
12Butanoate metabolism_Homo sapiens_hsa006501.82173519
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75395516
14Vitamin B6 metabolism_Homo sapiens_hsa007501.73901123
15Tryptophan metabolism_Homo sapiens_hsa003801.68640302
16Fatty acid degradation_Homo sapiens_hsa000711.64096207
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60065089
18GABAergic synapse_Homo sapiens_hsa047271.53690191
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50304811
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49769902
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42348098
22Acute myeloid leukemia_Homo sapiens_hsa052211.36821867
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34556001
24Nicotine addiction_Homo sapiens_hsa050331.32195511
25Bile secretion_Homo sapiens_hsa049761.31117549
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30034818
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29875026
28Propanoate metabolism_Homo sapiens_hsa006401.29403392
29ErbB signaling pathway_Homo sapiens_hsa040121.28624576
30Type II diabetes mellitus_Homo sapiens_hsa049301.27794139
31beta-Alanine metabolism_Homo sapiens_hsa004101.22277500
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22145657
33Sulfur relay system_Homo sapiens_hsa041221.21642101
34Amphetamine addiction_Homo sapiens_hsa050311.21505372
35Circadian entrainment_Homo sapiens_hsa047131.21281586
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.21017309
37Taste transduction_Homo sapiens_hsa047421.19567391
38Endocytosis_Homo sapiens_hsa041441.18919836
39Fructose and mannose metabolism_Homo sapiens_hsa000511.18028061
40* Regulation of autophagy_Homo sapiens_hsa041401.17764829
41Fatty acid metabolism_Homo sapiens_hsa012121.17111613
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15565665
43Glioma_Homo sapiens_hsa052141.13914979
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13883979
45Olfactory transduction_Homo sapiens_hsa047401.13023732
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.10491639
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.10166860
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10093250
49ABC transporters_Homo sapiens_hsa020101.09212002
50Collecting duct acid secretion_Homo sapiens_hsa049661.08435292
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06944655
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06912379
53Chronic myeloid leukemia_Homo sapiens_hsa052201.06387038
54Long-term potentiation_Homo sapiens_hsa047201.04685348
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04647558
56Circadian rhythm_Homo sapiens_hsa047101.04590172
57Glutamatergic synapse_Homo sapiens_hsa047241.04096810
58Thyroid cancer_Homo sapiens_hsa052161.02682947
59GnRH signaling pathway_Homo sapiens_hsa049121.02067841
60Choline metabolism in cancer_Homo sapiens_hsa052311.02043914
61Carbon metabolism_Homo sapiens_hsa012000.99761389
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99480957
63Peroxisome_Homo sapiens_hsa041460.99164991
64Folate biosynthesis_Homo sapiens_hsa007900.98875767
65PPAR signaling pathway_Homo sapiens_hsa033200.98850126
66Morphine addiction_Homo sapiens_hsa050320.98558942
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.97063295
68Pancreatic secretion_Homo sapiens_hsa049720.96262752
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95946218
70Biosynthesis of amino acids_Homo sapiens_hsa012300.95741083
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.94284617
72mTOR signaling pathway_Homo sapiens_hsa041500.93942821
73Non-small cell lung cancer_Homo sapiens_hsa052230.93844326
74Cocaine addiction_Homo sapiens_hsa050300.92018017
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91985233
76VEGF signaling pathway_Homo sapiens_hsa043700.91914134
77Fat digestion and absorption_Homo sapiens_hsa049750.91693665
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91260437
79Salivary secretion_Homo sapiens_hsa049700.90097724
80Lysosome_Homo sapiens_hsa041420.89308298
81Arginine and proline metabolism_Homo sapiens_hsa003300.88177571
82Glycerolipid metabolism_Homo sapiens_hsa005610.87080567
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85858892
84Osteoclast differentiation_Homo sapiens_hsa043800.85692666
85Dopaminergic synapse_Homo sapiens_hsa047280.85352943
86Histidine metabolism_Homo sapiens_hsa003400.82976750
87AMPK signaling pathway_Homo sapiens_hsa041520.82745192
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82437053
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.82033342
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81321326
91Sphingolipid metabolism_Homo sapiens_hsa006000.80269586
92Chemokine signaling pathway_Homo sapiens_hsa040620.78713908
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77827042
94Endometrial cancer_Homo sapiens_hsa052130.77456421
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77073343
96Starch and sucrose metabolism_Homo sapiens_hsa005000.76705464
97Selenocompound metabolism_Homo sapiens_hsa004500.76661152
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74852976
99Phenylalanine metabolism_Homo sapiens_hsa003600.74731790
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74257903
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74199660
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.74160107
103Estrogen signaling pathway_Homo sapiens_hsa049150.73597129
104Pyruvate metabolism_Homo sapiens_hsa006200.73529964
105Glucagon signaling pathway_Homo sapiens_hsa049220.73311307
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73232782
107Gastric acid secretion_Homo sapiens_hsa049710.73177482
108Prion diseases_Homo sapiens_hsa050200.73095925
109Complement and coagulation cascades_Homo sapiens_hsa046100.72116036
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71929525
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71331685
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70191956
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.69995784
114Cholinergic synapse_Homo sapiens_hsa047250.69624279
115Ras signaling pathway_Homo sapiens_hsa040140.69350529
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68708647
117Vibrio cholerae infection_Homo sapiens_hsa051100.68385344
118Calcium signaling pathway_Homo sapiens_hsa040200.67801939
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.67256119
120Galactose metabolism_Homo sapiens_hsa000520.65595292
121Sulfur metabolism_Homo sapiens_hsa009200.60372572
122Insulin signaling pathway_Homo sapiens_hsa049100.59606989
123Renal cell carcinoma_Homo sapiens_hsa052110.59005349
124Insulin resistance_Homo sapiens_hsa049310.58807846
125Hepatitis C_Homo sapiens_hsa051600.57743198
126Oxytocin signaling pathway_Homo sapiens_hsa049210.57697840
127Cardiac muscle contraction_Homo sapiens_hsa042600.57441801
128Shigellosis_Homo sapiens_hsa051310.57275246
129Inositol phosphate metabolism_Homo sapiens_hsa005620.57050830
130Fatty acid elongation_Homo sapiens_hsa000620.56838871
131HIF-1 signaling pathway_Homo sapiens_hsa040660.56402672
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55153634
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54257856
134TNF signaling pathway_Homo sapiens_hsa046680.52276256
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51546021
136MAPK signaling pathway_Homo sapiens_hsa040100.51434535
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51356116
138Apoptosis_Homo sapiens_hsa042100.51217175
139B cell receptor signaling pathway_Homo sapiens_hsa046620.51109104
140* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50997443
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50743844
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50542025
143T cell receptor signaling pathway_Homo sapiens_hsa046600.50140529
144Lysine degradation_Homo sapiens_hsa003100.49851446
145cAMP signaling pathway_Homo sapiens_hsa040240.49158505
146Prolactin signaling pathway_Homo sapiens_hsa049170.48924272
147Fatty acid biosynthesis_Homo sapiens_hsa000610.48221744
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48138512
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.46337966
150Bladder cancer_Homo sapiens_hsa052190.46256192
151Axon guidance_Homo sapiens_hsa043600.45109835
152Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44783364
153Pancreatic cancer_Homo sapiens_hsa052120.44613659
154Renin secretion_Homo sapiens_hsa049240.44292950

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