ATG16L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12914862
2G-protein coupled receptor internalization (GO:0002031)4.12265984
3protein localization to endosome (GO:0036010)4.02574834
4histone H3-K36 demethylation (GO:0070544)3.79880599
5embryonic process involved in female pregnancy (GO:0060136)3.75886031
6histone H3-K4 trimethylation (GO:0080182)3.69298815
7Golgi transport vesicle coating (GO:0048200)3.66287740
8COPI coating of Golgi vesicle (GO:0048205)3.66287740
9response to laminar fluid shear stress (GO:0034616)3.57038981
10regulation of RNA export from nucleus (GO:0046831)3.38804780
11regulation of nucleobase-containing compound transport (GO:0032239)3.37046538
12signal complex assembly (GO:0007172)3.33726967
13positive regulation of gamma-delta T cell activation (GO:0046645)3.31075351
14dosage compensation (GO:0007549)3.28560521
15nuclear pore organization (GO:0006999)3.26871128
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.23647309
17superoxide anion generation (GO:0042554)3.23432290
18spliceosomal tri-snRNP complex assembly (GO:0000244)3.17582145
19regulation of histone H3-K27 methylation (GO:0061085)3.14170431
20negative regulation of granulocyte differentiation (GO:0030853)3.11468670
21histone lysine demethylation (GO:0070076)2.98125616
22histone demethylation (GO:0016577)2.97802814
23negative regulation of DNA-dependent DNA replication (GO:2000104)2.92276743
24histone H3-K4 methylation (GO:0051568)2.89092640
25regulation of hexokinase activity (GO:1903299)2.88339882
26regulation of glucokinase activity (GO:0033131)2.88339882
27activation of Rac GTPase activity (GO:0032863)2.86438425
28cell-substrate adherens junction assembly (GO:0007045)2.86293415
29focal adhesion assembly (GO:0048041)2.86293415
30mitochondrion distribution (GO:0048311)2.84721208
31peptidyl-lysine trimethylation (GO:0018023)2.84233718
32regulation of necroptotic process (GO:0060544)2.83639384
33adherens junction assembly (GO:0034333)2.81628216
34dicarboxylic acid biosynthetic process (GO:0043650)2.81142503
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80158087
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79925694
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79885048
38adenosine metabolic process (GO:0046085)2.79830489
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78943576
40pore complex assembly (GO:0046931)2.78260105
41synaptic vesicle docking involved in exocytosis (GO:0016081)2.77960642
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77900673
43negative regulation of translation, ncRNA-mediated (GO:0040033)2.77900673
44regulation of translation, ncRNA-mediated (GO:0045974)2.77900673
45regulation of DNA endoreduplication (GO:0032875)2.76036380
46histone H3-K9 demethylation (GO:0033169)2.73872212
47phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.73593081
48negative regulation of erythrocyte differentiation (GO:0045647)2.72445850
49positive regulation of Cdc42 GTPase activity (GO:0043089)2.70141670
50negative regulation of protein localization to plasma membrane (GO:1903077)2.69967971
51cAMP catabolic process (GO:0006198)2.69569190
52ionotropic glutamate receptor signaling pathway (GO:0035235)2.69177965
53histone H3-K9 methylation (GO:0051567)2.67589118
54cell-substrate junction assembly (GO:0007044)2.67074053
55homocysteine metabolic process (GO:0050667)2.66605514
56hypotonic response (GO:0006971)2.64721670
57stress fiber assembly (GO:0043149)2.64196340
58regulation of glutamate receptor signaling pathway (GO:1900449)2.63859489
59tryptophan metabolic process (GO:0006568)2.63839632
60apoptotic process involved in morphogenesis (GO:0060561)2.63643298
61mitotic sister chromatid cohesion (GO:0007064)2.61968731
62positive regulation of humoral immune response (GO:0002922)2.61871202
63positive regulation of cellular amide metabolic process (GO:0034250)2.61106316
64regulation of NFAT protein import into nucleus (GO:0051532)2.61014220
65protein demethylation (GO:0006482)2.59968780
66protein dealkylation (GO:0008214)2.59968780
67negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.58915103
68tryptophan catabolic process (GO:0006569)2.58712421
69indole-containing compound catabolic process (GO:0042436)2.58712421
70indolalkylamine catabolic process (GO:0046218)2.58712421
71ribosome assembly (GO:0042255)2.58554075
72positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.57208255
73thymic T cell selection (GO:0045061)2.56866226
74opioid receptor signaling pathway (GO:0038003)2.56673075
75basic amino acid transport (GO:0015802)2.56207586
76NIK/NF-kappaB signaling (GO:0038061)2.55764740
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55421264
78negative regulation of necroptotic process (GO:0060546)2.53280938
79hemidesmosome assembly (GO:0031581)2.53178726
80regulation of B cell receptor signaling pathway (GO:0050855)2.52987891
81regulation of gamma-delta T cell differentiation (GO:0045586)2.52459525
82cerebellar Purkinje cell differentiation (GO:0021702)2.52360487
83positive T cell selection (GO:0043368)2.52158562
84regulation of ARF protein signal transduction (GO:0032012)2.51937214
85negative regulation of cell killing (GO:0031342)2.51528502
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51528502
87regulation of helicase activity (GO:0051095)2.51205098
88protein-lipid complex assembly (GO:0065005)2.50610494
89leukocyte aggregation (GO:0070486)2.49933675
90regulation of synapse maturation (GO:0090128)2.49775484
91cellular protein complex localization (GO:0034629)2.49353464
92T cell selection (GO:0045058)2.49215910
93response to host immune response (GO:0052572)2.48980751
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48980751
95snRNA transcription (GO:0009301)2.48269494
96regulation of anoikis (GO:2000209)2.47793570
97positive thymic T cell selection (GO:0045059)2.47611973
98negative thymic T cell selection (GO:0045060)2.47487347
99dentate gyrus development (GO:0021542)2.46374748
100replicative senescence (GO:0090399)2.46331021
101hepatocyte apoptotic process (GO:0097284)2.46070516
102DNA synthesis involved in DNA repair (GO:0000731)2.45682971
103synaptic transmission, glutamatergic (GO:0035249)2.45324322
104positive regulation of fibroblast migration (GO:0010763)2.43752156
105antigen processing and presentation of endogenous antigen (GO:0019883)2.43418470
106positive regulation of CREB transcription factor activity (GO:0032793)2.43201724
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.42632428
108interkinetic nuclear migration (GO:0022027)2.42577125
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.42510835
110regulation of gamma-delta T cell activation (GO:0046643)2.42096803
111regulation of transforming growth factor beta2 production (GO:0032909)2.42090507
112peptidyl-threonine phosphorylation (GO:0018107)2.41919148
113DNA strand renaturation (GO:0000733)2.40973079
114phosphatidylethanolamine metabolic process (GO:0046337)2.40389988
115urea cycle (GO:0000050)2.40368229
116urea metabolic process (GO:0019627)2.40368229
117peptidyl-threonine modification (GO:0018210)2.39505598
118negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.39211684
119histone lysine methylation (GO:0034968)2.38541955
120negative T cell selection (GO:0043383)2.38480539
121histone H3-K9 modification (GO:0061647)2.36564844
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.36260632
123response to pheromone (GO:0019236)2.35409842
124protein K6-linked ubiquitination (GO:0085020)2.35169693
125positive regulation of keratinocyte differentiation (GO:0045618)2.34144181
126negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.34022613
127amine catabolic process (GO:0009310)2.33973103
128cellular biogenic amine catabolic process (GO:0042402)2.33973103
129vesicle coating (GO:0006901)2.33725999
130germinal center formation (GO:0002467)2.33641786
131mannose metabolic process (GO:0006013)2.33431183
132regulation of defense response to virus by virus (GO:0050690)2.33408468
133phospholipid homeostasis (GO:0055091)2.32692577
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.32655176
135detection of other organism (GO:0098543)2.32157857
136regulation of cholesterol homeostasis (GO:2000188)2.31941507
137regulation of retinoic acid receptor signaling pathway (GO:0048385)2.31642319
138plasma lipoprotein particle assembly (GO:0034377)2.30142487
139positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30113979
140very-low-density lipoprotein particle assembly (GO:0034379)2.29863200
141alanine transport (GO:0032328)2.29266549
142COPII vesicle coating (GO:0048208)2.29135836
143phosphatidylglycerol biosynthetic process (GO:0006655)2.28275178
144cellular hyperosmotic response (GO:0071474)2.28270926
145response to muramyl dipeptide (GO:0032495)2.27731570
146response to host (GO:0075136)2.26774695
147response to host defenses (GO:0052200)2.26774695
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.26774695
149regulation of response to interferon-gamma (GO:0060330)2.26555878
150phosphorelay signal transduction system (GO:0000160)2.26348145
151regulation of protein polyubiquitination (GO:1902914)2.25452827
152activation of JUN kinase activity (GO:0007257)2.24802057
153chaperone mediated protein folding requiring cofactor (GO:0051085)2.24512443
154regulation of granulocyte differentiation (GO:0030852)2.24329511
1553-UTR-mediated mRNA stabilization (GO:0070935)2.23948419
156protein export from nucleus (GO:0006611)2.23946537
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.23874681
158modulation by virus of host process (GO:0019054)2.23862262
159positive regulation of insulin receptor signaling pathway (GO:0046628)2.23670312
160synaptic vesicle endocytosis (GO:0048488)2.22987733
161DNA integration (GO:0015074)2.22730648
162glycine transport (GO:0015816)2.22538135
163negative regulation of anoikis (GO:2000811)2.21911740
164mammary gland epithelial cell proliferation (GO:0033598)2.21182981
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.20891200
166cyclic nucleotide catabolic process (GO:0009214)2.20177953
167positive regulation of leukocyte apoptotic process (GO:2000108)2.19519589
168peptidyl-lysine methylation (GO:0018022)2.19303175
169nuclear pore complex assembly (GO:0051292)2.19129274
170male sex determination (GO:0030238)2.18440532
171receptor recycling (GO:0001881)2.18355199
172interferon-gamma secretion (GO:0072643)2.18114623
173neuron-neuron synaptic transmission (GO:0007270)2.17862981
174polyketide metabolic process (GO:0030638)2.16449826
175doxorubicin metabolic process (GO:0044598)2.16449826
176daunorubicin metabolic process (GO:0044597)2.16449826
177detection of bacterium (GO:0016045)2.16241963
178modulation by symbiont of host cellular process (GO:0044068)2.15986135
179monoubiquitinated protein deubiquitination (GO:0035520)2.15776664
180response to interleukin-15 (GO:0070672)2.15692130
181positive regulation of T cell apoptotic process (GO:0070234)2.14504059
182modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.14483884
183modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.14483884
184positive regulation by organism of defense response of other organism involved in symbiotic interact2.14483884
185modulation by symbiont of host immune response (GO:0052553)2.14483884
186positive regulation by symbiont of host defense response (GO:0052509)2.14483884
187modulation by symbiont of host defense response (GO:0052031)2.14483884
188glutamate receptor signaling pathway (GO:0007215)2.14316661
189I-kappaB phosphorylation (GO:0007252)2.14175401
190negative regulation of meiosis (GO:0045835)2.14141322
191early endosome to late endosome transport (GO:0045022)2.14037854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.26991127
2GBX2_23144817_ChIP-Seq_PC3_Human3.59419492
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.49713986
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35338274
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.16994890
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.13437633
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.06340160
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.97178466
9MYC_22102868_ChIP-Seq_BL_Human2.49672013
10TCF7_22412390_ChIP-Seq_EML_Mouse2.25999752
11* NFE2_27457419_Chip-Seq_LIVER_Mouse2.25785393
12* FLI1_27457419_Chip-Seq_LIVER_Mouse2.23588071
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22539621
14* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.21319732
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.20415956
16E2F7_22180533_ChIP-Seq_HELA_Human2.18854718
17* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15422893
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15302719
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11284939
20EZH2_22144423_ChIP-Seq_EOC_Human2.06448050
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03186513
22ZNF263_19887448_ChIP-Seq_K562_Human2.02942565
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02362227
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00868647
25* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.98794971
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.95734820
27* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94627444
28* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.93901434
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92313660
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87384649
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83068223
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82239686
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81963275
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.81390009
35CLOCK_20551151_ChIP-Seq_293T_Human1.80157393
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79879815
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79068924
38* EZH2_27294783_Chip-Seq_NPCs_Mouse1.78112627
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77865782
40DROSHA_22980978_ChIP-Seq_HELA_Human1.77093575
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.77031115
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75702553
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73827833
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73125384
45* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72940214
46KDM2B_26808549_Chip-Seq_DND41_Human1.69597945
47MAF_26560356_Chip-Seq_TH1_Human1.69526900
48STAT3_23295773_ChIP-Seq_U87_Human1.68795638
49VDR_21846776_ChIP-Seq_THP-1_Human1.67996467
50* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67168882
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.64032207
52* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61071812
53* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61071812
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61010795
55* E2F1_18555785_Chip-Seq_ESCs_Mouse1.60572386
56SMAD4_21799915_ChIP-Seq_A2780_Human1.60207177
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59934456
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.59301259
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59128576
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.58361237
61* NMYC_18555785_Chip-Seq_ESCs_Mouse1.57193268
62* NANOG_18555785_Chip-Seq_ESCs_Mouse1.54481679
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52853492
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48993836
65REST_21632747_ChIP-Seq_MESCs_Mouse1.48026150
66* PU1_27457419_Chip-Seq_LIVER_Mouse1.47908218
67TCF4_23295773_ChIP-Seq_U87_Human1.47397461
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47289388
69* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46398842
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46310557
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45862541
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45376664
73MYB_26560356_Chip-Seq_TH2_Human1.45295626
74* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43980432
75IGF1R_20145208_ChIP-Seq_DFB_Human1.43622438
76* STAT3_18555785_Chip-Seq_ESCs_Mouse1.43511592
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43283878
78* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43165863
79TFEB_21752829_ChIP-Seq_HELA_Human1.43009153
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.42580470
81* P53_22387025_ChIP-Seq_ESCs_Mouse1.42469098
82MYB_26560356_Chip-Seq_TH1_Human1.42434316
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.41912980
84CIITA_25753668_ChIP-Seq_RAJI_Human1.41305810
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40966361
86RACK7_27058665_Chip-Seq_MCF-7_Human1.40777116
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39455849
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39205341
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39108518
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38468938
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38367002
92* OCT4_18555785_Chip-Seq_ESCs_Mouse1.37482974
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37400465
94* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37119782
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36571137
96* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36562728
97SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35628210
98* CMYC_18555785_Chip-Seq_ESCs_Mouse1.35469753
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35319992
100* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34821153
101AHR_22903824_ChIP-Seq_MCF-7_Human1.34352036
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33884223
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.33834824
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33623475
105UTX_26944678_Chip-Seq_JUKART_Human1.33227799
106* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33206429
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32477321
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31864254
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31062396
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31052690
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.29822616
112MAF_26560356_Chip-Seq_TH2_Human1.28923067
113P300_19829295_ChIP-Seq_ESCs_Human1.28913228
114* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28655784
115* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28103038
116* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27699199
117* SOX2_18555785_Chip-Seq_ESCs_Mouse1.27331330
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26451647
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25368315
120* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24764623
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24725268
122TAF15_26573619_Chip-Seq_HEK293_Human1.24147345
123IRF8_27001747_Chip-Seq_BMDM_Mouse1.23784665
124* ZFX_18555785_Chip-Seq_ESCs_Mouse1.23729673
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23355728
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23355728
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22426566
128* CTCF_18555785_Chip-Seq_ESCs_Mouse1.22164826
129EWS_26573619_Chip-Seq_HEK293_Human1.22077911
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21889725
131GATA2_21666600_ChIP-Seq_HMVEC_Human1.21077601
132* P300_18555785_Chip-Seq_ESCs_Mouse1.20006715
133ESR1_20079471_ChIP-ChIP_T-47D_Human1.19791670
134* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18528020
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18157788
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17484111
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17244660
138* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16889303
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16557075
140TP63_19390658_ChIP-ChIP_HaCaT_Human1.16538763
141KDM2B_26808549_Chip-Seq_K562_Human1.16450296
142PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15868835
143ATF3_27146783_Chip-Seq_COLON_Human1.15752501
144NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14944862
145RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14639226
146ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14584621
147SPI1_23547873_ChIP-Seq_NB4_Human1.14170671
148NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13962489
149CHD1_26751641_Chip-Seq_LNCaP_Human1.13737159
150ARNT_22903824_ChIP-Seq_MCF-7_Human1.13736960
151RUNX2_22187159_ChIP-Seq_PCA_Human1.13441567
152* KLF4_18555785_Chip-Seq_ESCs_Mouse1.13377172
153SOX2_21211035_ChIP-Seq_LN229_Gbm1.12608022
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12511102
155* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11334713
156AR_19668381_ChIP-Seq_PC3_Human1.11313179
157* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10620990
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10598348
159EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10481681
160MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09879861
161* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09588311
162RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09540126
163EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09492259
164HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09436506
165AR_21572438_ChIP-Seq_LNCaP_Human1.09275009
166RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09167613
167WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08495898
168FOXM1_23109430_ChIP-Seq_U2OS_Human1.08433062
169NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07272368
170AR_25329375_ChIP-Seq_VCAP_Human1.06956266
171RARB_27405468_Chip-Seq_BRAIN_Mouse1.06310601
172* PU_27001747_Chip-Seq_BMDM_Mouse1.05650894
173* VDR_24763502_ChIP-Seq_THP-1_Human1.05374146
174UBF1/2_26484160_Chip-Seq_HMECs_Human1.05034867
175GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03962674
176* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03944106
177FOXO3_23340844_ChIP-Seq_DLD1_Human1.03875333
178RUNX_20019798_ChIP-Seq_JUKART_Human1.03775961
179ESR1_21235772_ChIP-Seq_MCF-7_Human1.03636499
180JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03539350
181* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02044724
182SMAD3_21741376_ChIP-Seq_HESCs_Human1.01868552
183GATA1_22025678_ChIP-Seq_K562_Human0.98775428
184TP53_16413492_ChIP-PET_HCT116_Human0.98644181
185MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98171941
186TBL1_22424771_ChIP-Seq_293T_Human0.96423926
187* ETV1_20927104_ChIP-Seq_GIST48_Human0.96382579
188IRF8_21731497_ChIP-ChIP_J774_Mouse0.95356201
189SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94429008
190RXR_22108803_ChIP-Seq_LS180_Human0.93185054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.15968641
2MP0004859_abnormal_synaptic_plasticity3.98650874
3MP0003787_abnormal_imprinting3.86543850
4* MP0008260_abnormal_autophagy3.69583612
5MP0005670_abnormal_white_adipose3.58040924
6MP0002822_catalepsy3.12442695
7MP0003191_abnormal_cellular_cholesterol2.94363140
8MP0001188_hyperpigmentation2.81908289
9MP0003705_abnormal_hypodermis_morpholog2.65511816
10MP0010234_abnormal_vibrissa_follicle2.62000221
11MP0009840_abnormal_foam_cell2.50360811
12MP0000015_abnormal_ear_pigmentation2.38869298
13MP0006292_abnormal_olfactory_placode2.36623401
14MP0010352_gastrointestinal_tract_polyps2.36043238
15MP0009697_abnormal_copulation2.33761291
16MP0003566_abnormal_cell_adhesion2.25673375
17MP0004510_myositis2.22703911
18MP0005076_abnormal_cell_differentiation2.10930088
19MP0003111_abnormal_nucleus_morphology2.09082120
20MP0008058_abnormal_DNA_repair2.08531224
21MP0003436_decreased_susceptibility_to2.03948273
22MP0005085_abnormal_gallbladder_physiolo1.98469388
23MP0005365_abnormal_bile_salt1.97813416
24MP0004185_abnormal_adipocyte_glucose1.95058306
25MP0004947_skin_inflammation1.87295769
26MP0002796_impaired_skin_barrier1.85861255
27MP0005174_abnormal_tail_pigmentation1.83019651
28MP0003453_abnormal_keratinocyte_physiol1.82178761
29MP0005646_abnormal_pituitary_gland1.82119051
30MP0000371_diluted_coat_color1.79442942
31MP0004264_abnormal_extraembryonic_tissu1.77081896
32MP0005451_abnormal_body_composition1.75150375
33MP0008961_abnormal_basal_metabolism1.74142521
34MP0009745_abnormal_behavioral_response1.70874202
35MP0005058_abnormal_lysosome_morphology1.67625058
36MP0005409_darkened_coat_color1.66726435
37MP0001986_abnormal_taste_sensitivity1.62135816
38MP0003252_abnormal_bile_duct1.61538400
39MP0010094_abnormal_chromosome_stability1.60528925
40MP0002876_abnormal_thyroid_physiology1.60293788
41MP0008995_early_reproductive_senescence1.58846543
42MP0002102_abnormal_ear_morphology1.58606600
43MP0001501_abnormal_sleep_pattern1.56556676
44MP0001915_intracranial_hemorrhage1.55914928
45MP0003635_abnormal_synaptic_transmissio1.54001009
46MP0000858_altered_metastatic_potential1.52874106
47MP0002063_abnormal_learning/memory/cond1.52171411
48MP0004233_abnormal_muscle_weight1.51228079
49MP0001730_embryonic_growth_arrest1.51006817
50MP0003828_pulmonary_edema1.49562980
51MP0003221_abnormal_cardiomyocyte_apopto1.45619790
52MP0005501_abnormal_skin_physiology1.45202695
53MP0010307_abnormal_tumor_latency1.42693623
54* MP0005621_abnormal_cell_physiology1.42587553
55MP0000465_gastrointestinal_hemorrhage1.41421025
56MP0003329_amyloid_beta_deposits1.39292281
57MP0001849_ear_inflammation1.38226850
58MP0003300_gastrointestinal_ulcer1.36486124
59MP0002060_abnormal_skin_morphology1.35879205
60MP0008877_abnormal_DNA_methylation1.34499850
61MP0001984_abnormal_olfaction1.33501818
62MP0002877_abnormal_melanocyte_morpholog1.33090372
63MP0002139_abnormal_hepatobiliary_system1.31193450
64MP0001835_abnormal_antigen_presentation1.30765046
65MP0002086_abnormal_extraembryonic_tissu1.30291441
66MP0004957_abnormal_blastocyst_morpholog1.29683124
67MP0002735_abnormal_chemical_nociception1.28927986
68MP0003693_abnormal_embryo_hatching1.28608435
69MP0002396_abnormal_hematopoietic_system1.27978466
70MP0000703_abnormal_thymus_morphology1.27954971
71MP0001486_abnormal_startle_reflex1.27943863
72MP0003183_abnormal_peptide_metabolism1.24991611
73MP0000350_abnormal_cell_proliferation1.24354682
74MP0005645_abnormal_hypothalamus_physiol1.24065006
75MP0009764_decreased_sensitivity_to1.22197541
76MP0003172_abnormal_lysosome_physiology1.21314282
77MP0003984_embryonic_growth_retardation1.20946569
78MP0002138_abnormal_hepatobiliary_system1.17034372
79MP0005360_urolithiasis1.16006282
80MP0002088_abnormal_embryonic_growth/wei1.15840508
81MP0001216_abnormal_epidermal_layer1.15462813
82MP0001851_eye_inflammation1.14854108
83MP0000604_amyloidosis1.14810992
84MP0005380_embryogenesis_phenotype1.14692991
85MP0001672_abnormal_embryogenesis/_devel1.14692991
86MP0003077_abnormal_cell_cycle1.12631195
87MP0009046_muscle_twitch1.12102696
88MP0002398_abnormal_bone_marrow1.12042048
89MP0003718_maternal_effect1.11504290
90MP0002166_altered_tumor_susceptibility1.10527239
91MP0002009_preneoplasia1.09945229
92MP0000427_abnormal_hair_cycle1.09772243
93MP0002572_abnormal_emotion/affect_behav1.09526585
94MP0003943_abnormal_hepatobiliary_system1.08863447
95MP0001119_abnormal_female_reproductive1.08230177
96MP0005647_abnormal_sex_gland1.07635359
97MP0003303_peritoneal_inflammation1.07035298
98MP0010329_abnormal_lipoprotein_level1.06503395
99* MP0010155_abnormal_intestine_physiology1.05564180
100MP0002928_abnormal_bile_duct1.05445890
101MP0001968_abnormal_touch/_nociception1.05324056
102MP0005257_abnormal_intraocular_pressure1.05061670
103MP0009333_abnormal_splenocyte_physiolog1.04124041
104* MP0005384_cellular_phenotype1.03780372
105MP0009278_abnormal_bone_marrow1.03700167
106MP0003121_genomic_imprinting1.03151541
107MP0000733_abnormal_muscle_development1.02709389
108MP0005397_hematopoietic_system_phenotyp1.02028917
109MP0001545_abnormal_hematopoietic_system1.02028917
110MP0003879_abnormal_hair_cell1.01982919
111MP0003763_abnormal_thymus_physiology1.01503120
112* MP0002420_abnormal_adaptive_immunity1.00770919
113MP0005023_abnormal_wound_healing1.00591774
114MP0002080_prenatal_lethality1.00327821
115MP0002332_abnormal_exercise_endurance0.99845546
116* MP0001819_abnormal_immune_cell0.99131941
117MP0001800_abnormal_humoral_immune0.99005371
118MP0001502_abnormal_circadian_rhythm0.98414240
119MP0001873_stomach_inflammation0.97697022
120MP0003656_abnormal_erythrocyte_physiolo0.97502309
121MP0005171_absent_coat_pigmentation0.97410395
122MP0002722_abnormal_immune_system0.97126204
123MP0005000_abnormal_immune_tolerance0.94373914
124* MP0000490_abnormal_crypts_of0.93501003
125MP0002075_abnormal_coat/hair_pigmentati0.93460952
126MP0000537_abnormal_urethra_morphology0.93144477
127MP0002557_abnormal_social/conspecific_i0.92883277
128MP0001348_abnormal_lacrimal_gland0.91336951
129MP0000716_abnormal_immune_system0.90616797
130MP0002405_respiratory_system_inflammati0.90372133
131MP0008007_abnormal_cellular_replicative0.90246716
132MP0005551_abnormal_eye_electrophysiolog0.89801052
133MP0003646_muscle_fatigue0.89709738
134MP0002006_tumorigenesis0.89054676
135MP0004381_abnormal_hair_follicle0.89039051
136MP0005075_abnormal_melanosome_morpholog0.88619966
137MP0001177_atelectasis0.87963319
138MP0002067_abnormal_sensory_capabilities0.87527673
139MP0004484_altered_response_of0.85974245
140MP0003045_fibrosis0.84744609
141MP0004215_abnormal_myocardial_fiber0.83519925
142MP0008057_abnormal_DNA_replication0.82783245
143MP0002429_abnormal_blood_cell0.82721009
144MP0000689_abnormal_spleen_morphology0.81921353
145MP0010630_abnormal_cardiac_muscle0.81821492
146MP0002184_abnormal_innervation0.81754694
147MP0000313_abnormal_cell_death0.81622694
148MP0002095_abnormal_skin_pigmentation0.80741709
149MP0001697_abnormal_embryo_size0.80468754
150MP0005025_abnormal_response_to0.79160098
151MP0002064_seizures0.77617549
152MP0005535_abnormal_body_temperature0.77515513
153MP0009765_abnormal_xenobiotic_induced0.77391385
154MP0003699_abnormal_female_reproductive0.77325718
155MP0005464_abnormal_platelet_physiology0.76935578
156MP0009931_abnormal_skin_appearance0.76378627
157MP0002638_abnormal_pupillary_reflex0.76049102
158MP0001790_abnormal_immune_system0.75366834
159MP0005387_immune_system_phenotype0.75366834
160MP0009780_abnormal_chondrocyte_physiolo0.74570922
161MP0003786_premature_aging0.74378842
162MP0001186_pigmentation_phenotype0.74259806
163MP0001440_abnormal_grooming_behavior0.73590216
164MP0003115_abnormal_respiratory_system0.72531876
165MP0003866_abnormal_defecation0.72391289
166MP0004808_abnormal_hematopoietic_stem0.71694786
167MP0001853_heart_inflammation0.71586906
168MP0005395_other_phenotype0.71298134
169* MP0002419_abnormal_innate_immunity0.69558317
170* MP0002723_abnormal_immune_serum0.69395743
171MP0003941_abnormal_skin_development0.68388640
172MP0000609_abnormal_liver_physiology0.67530483
173MP0003890_abnormal_embryonic-extraembry0.66671055
174MP0005334_abnormal_fat_pad0.66513636
175MP0003868_abnormal_feces_composition0.66395982
176MP0003091_abnormal_cell_migration0.65777021
177MP0005310_abnormal_salivary_gland0.64732220
178* MP0002452_abnormal_antigen_presenting0.64471364

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.61863255
2Chromsome breakage (HP:0040012)5.12974625
3Febrile seizures (HP:0002373)4.56805557
4Prostate neoplasm (HP:0100787)3.95792299
5Subacute progressive viral hepatitis (HP:0006572)3.45680489
6Distal lower limb amyotrophy (HP:0008944)3.19032957
7Broad face (HP:0000283)3.16582671
8Abnormality of the fingertips (HP:0001211)3.15575193
9Protruding tongue (HP:0010808)3.10614746
10Abnormal delayed hypersensitivity skin test (HP:0002963)2.91037069
11Anal stenosis (HP:0002025)2.85467353
12Renal cortical cysts (HP:0000803)2.80164985
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.77647183
14Eczematoid dermatitis (HP:0000976)2.74552761
15Congenital stationary night blindness (HP:0007642)2.74470107
16Lower limb amyotrophy (HP:0007210)2.73543538
17Fair hair (HP:0002286)2.71188431
18Focal motor seizures (HP:0011153)2.70080892
19Arterial tortuosity (HP:0005116)2.65904944
20Slow saccadic eye movements (HP:0000514)2.62585004
21Generalized hypopigmentation of hair (HP:0011358)2.57094434
22Duplicated collecting system (HP:0000081)2.51097880
23Abnormality of pyrimidine metabolism (HP:0004353)2.50966810
24Micronodular cirrhosis (HP:0001413)2.50023738
25Chronic mucocutaneous candidiasis (HP:0002728)2.48696673
26Recurrent cutaneous fungal infections (HP:0011370)2.48696673
27Shoulder girdle muscle weakness (HP:0003547)2.44905103
28Abnormality of the prostate (HP:0008775)2.43166168
29Flat acetabular roof (HP:0003180)2.42450038
30Neoplasm of the adrenal cortex (HP:0100641)2.42076784
31Upper limb muscle weakness (HP:0003484)2.41166220
32Insidious onset (HP:0003587)2.37382866
33Termporal pattern (HP:0011008)2.37382866
34Abnormality of DNA repair (HP:0003254)2.37238917
35Vascular tortuosity (HP:0004948)2.33244809
36Abnormality of the renal collecting system (HP:0004742)2.29330736
37Ankyloglossia (HP:0010296)2.28865706
38Fatigue (HP:0012378)2.28092131
39Abnormality of oral frenula (HP:0000190)2.27760102
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.26553212
41Recurrent fungal infections (HP:0002841)2.24253809
42Pelvic girdle muscle weakness (HP:0003749)2.23818033
43Distal lower limb muscle weakness (HP:0009053)2.20567269
44Colitis (HP:0002583)2.16843849
45Postural instability (HP:0002172)2.16698694
46Oligodactyly (hands) (HP:0001180)2.16504337
47Osteolytic defects of the hand bones (HP:0009699)2.14950815
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.14950815
49Poor eye contact (HP:0000817)2.14591065
50Abnormality of the carotid arteries (HP:0005344)2.14387649
51Long palpebral fissure (HP:0000637)2.14287152
52Ankle clonus (HP:0011448)2.13162845
53Distal upper limb amyotrophy (HP:0007149)2.11863269
54Upper limb amyotrophy (HP:0009129)2.11863269
55Chronic hepatic failure (HP:0100626)2.10272705
56Deep venous thrombosis (HP:0002625)2.08723077
57Clubbing of toes (HP:0100760)2.08100982
58Status epilepticus (HP:0002133)2.07333101
59Focal seizures (HP:0007359)2.05646376
60Albinism (HP:0001022)2.04745148
61Blue irides (HP:0000635)2.04120392
62Viral hepatitis (HP:0006562)2.02806933
63Joint hemorrhage (HP:0005261)2.02642065
64Panhypogammaglobulinemia (HP:0003139)2.02505325
65Abnormality of chromosome stability (HP:0003220)2.02375935
66Cerebral aneurysm (HP:0004944)2.01833097
67Gingival bleeding (HP:0000225)2.00892044
68Milia (HP:0001056)2.00229794
69Entropion (HP:0000621)1.99368655
70T lymphocytopenia (HP:0005403)1.99201052
71Spastic gait (HP:0002064)1.98826335
72Abnormality of the preputium (HP:0100587)1.98741002
73Impaired social interactions (HP:0000735)1.96021785
74Abnormal social behavior (HP:0012433)1.96021785
75Difficulty climbing stairs (HP:0003551)1.95209989
76Recurrent bacterial skin infections (HP:0005406)1.95084032
77Impulsivity (HP:0100710)1.94273955
78Lip pit (HP:0100267)1.93878694
79Interstitial pulmonary disease (HP:0006530)1.93601616
80Osteomalacia (HP:0002749)1.91365229
81Ectopic kidney (HP:0000086)1.91056330
82Abnormality of the distal phalanges of the toes (HP:0010182)1.90814067
83Absent speech (HP:0001344)1.90424793
84Meckel diverticulum (HP:0002245)1.89379791
85Centrally nucleated skeletal muscle fibers (HP:0003687)1.87511740
86Abnormality of macrophages (HP:0004311)1.86912651
87Alveolar cell carcinoma (HP:0006519)1.85175912
88Neoplasm of the tracheobronchial system (HP:0100552)1.84850422
89Hand muscle atrophy (HP:0009130)1.84839939
90Urethral obstruction (HP:0000796)1.84500825
91Dislocated radial head (HP:0003083)1.83783162
92Increased connective tissue (HP:0009025)1.82154118
93Generalized tonic-clonic seizures (HP:0002069)1.81991071
94Abnormality of the hip-girdle musculature (HP:0001445)1.81827841
95Abnormality of the musculature of the pelvis (HP:0001469)1.81827841
96Basal cell carcinoma (HP:0002671)1.81501390
97Prolonged bleeding time (HP:0003010)1.80957921
98Spinal cord lesions (HP:0100561)1.80718266
99Syringomyelia (HP:0003396)1.80718266
100Aplasia/Hypoplasia of the macula (HP:0008059)1.80330781
101Distal sensory impairment (HP:0002936)1.79891003
102Sparse lateral eyebrow (HP:0005338)1.79620646
103Short nail (HP:0001799)1.79355820
104Generalized hypopigmentation (HP:0007513)1.78953183
105Mesomelia (HP:0003027)1.78641525
106Gaze-evoked nystagmus (HP:0000640)1.77615104
107Recurrent abscess formation (HP:0002722)1.77161595
108Cerebral inclusion bodies (HP:0100314)1.76509696
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.75937230
110Hypoplasia of the fovea (HP:0007750)1.75937230
111Selective tooth agenesis (HP:0001592)1.75222685
112Progressive external ophthalmoplegia (HP:0000590)1.74431907
113Ulnar bowing (HP:0003031)1.74094683
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.73642721
115Coarse hair (HP:0002208)1.73561121
116Urinary urgency (HP:0000012)1.73064239
117Epileptic encephalopathy (HP:0200134)1.71905927
118Metaphyseal cupping (HP:0003021)1.71104174
119Abnormal platelet volume (HP:0011876)1.71057978
120Elfin facies (HP:0004428)1.70993191
121Frequent falls (HP:0002359)1.70975263
122Amyotrophic lateral sclerosis (HP:0007354)1.70920370
123Cellulitis (HP:0100658)1.70144950
124Abnormality of the ileum (HP:0001549)1.70030117
125Vertebral arch anomaly (HP:0008438)1.69918142
126Recurrent viral infections (HP:0004429)1.69484637
127Microvesicular hepatic steatosis (HP:0001414)1.69473840
128Decreased central vision (HP:0007663)1.69351121
129Abnormality of the lower motor neuron (HP:0002366)1.69169903
130Hemiplegia (HP:0002301)1.68341722
131Severe visual impairment (HP:0001141)1.68210205
132Abnormality of T cell number (HP:0011839)1.68010609
133Asymmetry of the thorax (HP:0001555)1.67891724
134Excessive salivation (HP:0003781)1.67739301
135Drooling (HP:0002307)1.67739301
136Conjugated hyperbilirubinemia (HP:0002908)1.66995975
137Urinary bladder sphincter dysfunction (HP:0002839)1.66278318
138Hemorrhage of the eye (HP:0011885)1.66171337
139Thick nail (HP:0001805)1.66169952
140Absent frontal sinuses (HP:0002688)1.66157988
141Submucous cleft hard palate (HP:0000176)1.66139734
142Spondylolisthesis (HP:0003302)1.65822398
143Pustule (HP:0200039)1.65751062
144Pendular nystagmus (HP:0012043)1.65496162
145Neuronal loss in central nervous system (HP:0002529)1.64925663
146Tetraparesis (HP:0002273)1.64289785
147Gingivitis (HP:0000230)1.63665786
148Upper motor neuron abnormality (HP:0002127)1.63654401
149Abnormality of the labia minora (HP:0012880)1.62340630
150Delayed puberty (HP:0000823)1.62319499
151Cheilitis (HP:0100825)1.61869187
152Cubitus valgus (HP:0002967)1.61867393
153Long eyelashes (HP:0000527)1.61682755
154Dilatation of the ascending aorta (HP:0005111)1.60861738
155Progressive cerebellar ataxia (HP:0002073)1.60716208
156Mask-like facies (HP:0000298)1.60710444
157Mediastinal lymphadenopathy (HP:0100721)1.60307317
158Chronic diarrhea (HP:0002028)1.60210276
159Renal cell carcinoma (HP:0005584)1.59520449
160Heterotopia (HP:0002282)1.59490598
161Prominent nose (HP:0000448)1.59343807
162Abnormality of the nasal septum (HP:0000419)1.59197133
163Hypoplasia of the thymus (HP:0000778)1.59095476
164Myocardial infarction (HP:0001658)1.58755847
165Abnormality of homocysteine metabolism (HP:0010919)1.57678088
166Homocystinuria (HP:0002156)1.57678088
167Ragged-red muscle fibers (HP:0003200)1.57417069
168Increased mean platelet volume (HP:0011877)1.57303981
169Atrophic scars (HP:0001075)1.57108295
170Progressive hearing impairment (HP:0001730)1.56344778
171Neurofibrillary tangles (HP:0002185)1.55963268
172Papillary thyroid carcinoma (HP:0002895)1.55372335
173Abnormality of the radial head (HP:0003995)1.55087976
174Poikiloderma (HP:0001029)1.55081999
175Vertebral compression fractures (HP:0002953)1.54955645
176Peripheral hypomyelination (HP:0007182)1.54890564
177Exotropia (HP:0000577)1.54760378
178Deep philtrum (HP:0002002)1.54663748
179Thin bony cortex (HP:0002753)1.54271739
180J-shaped sella turcica (HP:0002680)1.53938675
181Acute hepatic failure (HP:0006554)1.53620253
182Periodontitis (HP:0000704)1.53553791
183Increased IgM level (HP:0003496)1.53315094
184Bundle branch block (HP:0011710)1.53236193
185Lower limb muscle weakness (HP:0007340)1.53029379
186Bile duct proliferation (HP:0001408)1.53012706
187Abnormal biliary tract physiology (HP:0012439)1.53012706
188Abnormality of the distal phalanx of the thumb (HP:0009617)1.52888709
189Achilles tendon contracture (HP:0001771)1.52803086
190Deviation of the thumb (HP:0009603)1.51812900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K133.75531294
2BRD43.18049460
3TRIB33.04732812
4BMPR22.81300716
5CAMK1D2.63629954
6MST1R2.61155965
7AKT32.40043012
8SCYL22.36174220
9ZAK2.34451665
10CDK122.32052164
11NTRK32.23831723
12MAP3K142.19460651
13DAPK22.14842565
14EPHA42.12682129
15SIK22.04931059
16IRAK32.03094161
17TAOK31.98078629
18MAP3K91.95519800
19LMTK21.95213070
20SGK21.83652268
21EPHB11.80608937
22MAP2K31.79469193
23TTN1.73656226
24CAMK1G1.72669081
25INSRR1.67785857
26TXK1.67111450
27ICK1.62544139
28MAP3K31.60016108
29PDGFRA1.57758185
30EIF2AK21.53572593
31SMG11.52751428
32TRIM281.47485216
33KSR11.45594656
34MAP3K41.44422793
35MAP2K71.43798392
36MAP3K21.43394864
37KSR21.43316670
38FRK1.41986172
39SIK31.39238849
40RIPK41.39104986
41SGK31.38053512
42SIK11.37713992
43TSSK61.32796455
44JAK11.26534932
45STK101.25599298
46PAK41.24545770
47ZAP701.24013498
48GRK11.23242669
49ERN11.21079527
50IRAK41.14656608
51PLK41.14000255
52STK381.13886726
53MOS1.11408494
54JAK31.11263201
55MAP3K11.11070943
56PINK11.09220126
57TAOK21.04333522
58MKNK21.01926402
59GRK60.99712424
60ERBB30.98745591
61EPHA20.95679935
62TNK20.95399397
63CAMK40.93980155
64SGK10.92851766
65MAP3K100.92695340
66STK38L0.92152823
67CDK30.90511343
68CASK0.90392969
69PDGFRB0.90389554
70MELK0.90089459
71CDK60.89043307
72TBK10.87447087
73BCR0.87415744
74IKBKE0.86549475
75TTK0.86000172
76NEK60.85828252
77RIPK10.85548034
78PKN20.85380923
79FGR0.85226183
80PRPF4B0.85188424
81CDK90.84645134
82MAP3K60.81739133
83MAPK70.81097689
84PIK3CG0.81028468
85MARK30.81006736
86CHUK0.80212587
87MAP3K50.79692720
88MTOR0.79018562
89MET0.78830068
90PTK60.77144383
91BTK0.77029165
92CAMKK20.76558050
93PLK20.75361690
94LATS20.74424380
95SGK4940.73945707
96SGK2230.73945707
97CDK40.72967934
98EEF2K0.72886941
99PTK20.71658504
100BMX0.70972419
101MAP3K110.70535345
102PBK0.67479295
103CAMK10.67199188
104ATR0.67045754
105FGFR30.66694245
106IRAK20.66576889
107STK240.65788149
108MAP3K70.65589064
109ERBB40.65283429
110RAF10.64312486
111TNIK0.63374149
112FGFR40.62224477
113MAP3K120.61873195
114DAPK10.61844995
115WNK10.61531066
116DYRK1B0.60919088
117MAP4K10.60384369
118TYK20.59643566
119LATS10.59139522
120PRKAA20.58527010
121PRKAA10.57187144
122NTRK20.56996191
123CAMKK10.56778748
124HCK0.56290743
125ALK0.56238028
126MAP3K80.54559078
127PAK60.54549819
128TESK20.54325309
129RET0.53415509
130MAP2K40.51788671
131NLK0.51722830
132PIM10.51707254
133YES10.51401492
134ITK0.51254017
135PRKCH0.50585704
136TESK10.50544356
137STK110.49818881
138FES0.48231535
139LRRK20.47385617
140IKBKB0.47211621
141MAPK130.47063405
142LCK0.46735151
143TYRO30.45985738
144EGFR0.45811959
145DYRK1A0.45589761
146PRKD30.45251183
147RPS6KB10.44519072
148MAPK110.43678496
149MARK20.42122348
150AKT20.40053777
151ATM0.39540919
152STK40.39160491
153AKT10.38982710
154PRKCG0.38526282
155FGFR20.37788162
156BLK0.37637094
157GSK3B0.37459185
158MAPK140.36684377
159MAPK100.36320787
160TAOK10.36103482
161CDC42BPA0.36062541
162CSK0.35917216

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.46323183
2Olfactory transduction_Homo sapiens_hsa047402.32956694
3Chronic myeloid leukemia_Homo sapiens_hsa052201.95661415
4Acute myeloid leukemia_Homo sapiens_hsa052211.86658956
5Morphine addiction_Homo sapiens_hsa050321.86498600
6Pancreatic cancer_Homo sapiens_hsa052121.85114434
7Non-small cell lung cancer_Homo sapiens_hsa052231.84581220
8Lysine degradation_Homo sapiens_hsa003101.79618007
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.70789026
10Arginine biosynthesis_Homo sapiens_hsa002201.62397176
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59591073
12Fanconi anemia pathway_Homo sapiens_hsa034601.56939254
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55628539
14Thyroid cancer_Homo sapiens_hsa052161.54600016
15Renal cell carcinoma_Homo sapiens_hsa052111.53607153
16T cell receptor signaling pathway_Homo sapiens_hsa046601.50395195
17ABC transporters_Homo sapiens_hsa020101.48787655
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.45783346
19Other glycan degradation_Homo sapiens_hsa005111.45120840
20Shigellosis_Homo sapiens_hsa051311.43919746
21Hepatitis B_Homo sapiens_hsa051611.42401807
22Circadian rhythm_Homo sapiens_hsa047101.38517714
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36424890
24Inositol phosphate metabolism_Homo sapiens_hsa005621.35868759
25One carbon pool by folate_Homo sapiens_hsa006701.35152605
26Adherens junction_Homo sapiens_hsa045201.33596719
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31850282
28VEGF signaling pathway_Homo sapiens_hsa043701.30576559
29Colorectal cancer_Homo sapiens_hsa052101.29142330
30Type II diabetes mellitus_Homo sapiens_hsa049301.28949015
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27981880
32Glutamatergic synapse_Homo sapiens_hsa047241.27257455
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26304015
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.24862957
35Phototransduction_Homo sapiens_hsa047441.24011345
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.23706510
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.22629808
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22181843
39Synaptic vesicle cycle_Homo sapiens_hsa047211.21006889
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16748465
41Proteoglycans in cancer_Homo sapiens_hsa052051.16324466
42Viral carcinogenesis_Homo sapiens_hsa052031.16048041
43Staphylococcus aureus infection_Homo sapiens_hsa051501.14871135
44Taste transduction_Homo sapiens_hsa047421.14839161
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12919249
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12103307
47Prostate cancer_Homo sapiens_hsa052151.10895793
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10307865
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09434718
50Toxoplasmosis_Homo sapiens_hsa051451.09327627
51Circadian entrainment_Homo sapiens_hsa047131.08565476
52Insulin secretion_Homo sapiens_hsa049111.07493418
53Endocytosis_Homo sapiens_hsa041441.06460497
54Complement and coagulation cascades_Homo sapiens_hsa046101.04944318
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04004681
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02574465
57Ovarian steroidogenesis_Homo sapiens_hsa049131.00972996
58GABAergic synapse_Homo sapiens_hsa047271.00126273
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99425208
60Calcium signaling pathway_Homo sapiens_hsa040200.97688202
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97453735
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95695161
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93793642
64Influenza A_Homo sapiens_hsa051640.93264884
65Viral myocarditis_Homo sapiens_hsa054160.93176915
66MicroRNAs in cancer_Homo sapiens_hsa052060.92322827
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91537845
68TNF signaling pathway_Homo sapiens_hsa046680.91497184
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91425511
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.91150974
71Cholinergic synapse_Homo sapiens_hsa047250.90651426
72Pentose phosphate pathway_Homo sapiens_hsa000300.89695087
73HIF-1 signaling pathway_Homo sapiens_hsa040660.88669857
74Focal adhesion_Homo sapiens_hsa045100.88251572
75HTLV-I infection_Homo sapiens_hsa051660.88022156
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86151283
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.85138211
78Leishmaniasis_Homo sapiens_hsa051400.85100708
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84990177
80Primary immunodeficiency_Homo sapiens_hsa053400.84487801
81Herpes simplex infection_Homo sapiens_hsa051680.84387554
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83901091
83AMPK signaling pathway_Homo sapiens_hsa041520.83451693
84Long-term potentiation_Homo sapiens_hsa047200.81752956
85cAMP signaling pathway_Homo sapiens_hsa040240.81220182
86FoxO signaling pathway_Homo sapiens_hsa040680.79783652
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79626432
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79544426
89Oxytocin signaling pathway_Homo sapiens_hsa049210.77891516
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.77675831
91mRNA surveillance pathway_Homo sapiens_hsa030150.76278711
92Epstein-Barr virus infection_Homo sapiens_hsa051690.75520431
93Choline metabolism in cancer_Homo sapiens_hsa052310.75362128
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.75221901
95Measles_Homo sapiens_hsa051620.75014951
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74608307
97beta-Alanine metabolism_Homo sapiens_hsa004100.73939360
98Chemokine signaling pathway_Homo sapiens_hsa040620.73807681
99Bladder cancer_Homo sapiens_hsa052190.69947101
100Legionellosis_Homo sapiens_hsa051340.69730285
101Sphingolipid metabolism_Homo sapiens_hsa006000.69601458
102GnRH signaling pathway_Homo sapiens_hsa049120.69302002
103Salivary secretion_Homo sapiens_hsa049700.69262377
104mTOR signaling pathway_Homo sapiens_hsa041500.68567530
105Osteoclast differentiation_Homo sapiens_hsa043800.67570512
106Estrogen signaling pathway_Homo sapiens_hsa049150.67541241
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66472823
108Hematopoietic cell lineage_Homo sapiens_hsa046400.66285527
109Type I diabetes mellitus_Homo sapiens_hsa049400.65838041
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65537065
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64521790
112Insulin resistance_Homo sapiens_hsa049310.63697910
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63098461
114Amoebiasis_Homo sapiens_hsa051460.62886401
115Vitamin B6 metabolism_Homo sapiens_hsa007500.62373196
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62258916
117Graft-versus-host disease_Homo sapiens_hsa053320.60665724
118Amphetamine addiction_Homo sapiens_hsa050310.59427997
119Endometrial cancer_Homo sapiens_hsa052130.58588951
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57629906
121MAPK signaling pathway_Homo sapiens_hsa040100.57486037
122Platelet activation_Homo sapiens_hsa046110.56553443
123Glucagon signaling pathway_Homo sapiens_hsa049220.56218898
124Hepatitis C_Homo sapiens_hsa051600.54983453
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53889258
126Tuberculosis_Homo sapiens_hsa051520.53016221
127Cell cycle_Homo sapiens_hsa041100.52668274
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.52403945
129Systemic lupus erythematosus_Homo sapiens_hsa053220.52401587
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.51748458
131B cell receptor signaling pathway_Homo sapiens_hsa046620.51594303
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51426356
133Apoptosis_Homo sapiens_hsa042100.50134709
134Dopaminergic synapse_Homo sapiens_hsa047280.49421496
135Notch signaling pathway_Homo sapiens_hsa043300.48799715
136Salmonella infection_Homo sapiens_hsa051320.48665225
137Prion diseases_Homo sapiens_hsa050200.48616000
138Rap1 signaling pathway_Homo sapiens_hsa040150.48342011
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47714043
140Prolactin signaling pathway_Homo sapiens_hsa049170.47697817
141Small cell lung cancer_Homo sapiens_hsa052220.47110039
142Tryptophan metabolism_Homo sapiens_hsa003800.45698104
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.45202844
144Starch and sucrose metabolism_Homo sapiens_hsa005000.44904809
145Vitamin digestion and absorption_Homo sapiens_hsa049770.44704509
146Glioma_Homo sapiens_hsa052140.44354902
147Bile secretion_Homo sapiens_hsa049760.44029138
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43519701
149Long-term depression_Homo sapiens_hsa047300.42362754
150Non-homologous end-joining_Homo sapiens_hsa034500.42192855
151Allograft rejection_Homo sapiens_hsa053300.41981741
152Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40939277
153Serotonergic synapse_Homo sapiens_hsa047260.40824346
154Dorso-ventral axis formation_Homo sapiens_hsa043200.40596219
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40051040
156ErbB signaling pathway_Homo sapiens_hsa040120.39975146
157Insulin signaling pathway_Homo sapiens_hsa049100.39711032

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