ATG16L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.74058013
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.79243630
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.79243630
4modulation by symbiont of host immune response (GO:0052553)5.79243630
5positive regulation by symbiont of host defense response (GO:0052509)5.79243630
6modulation by symbiont of host defense response (GO:0052031)5.79243630
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.79243630
8detection of other organism (GO:0098543)5.23826677
9detection of bacterium (GO:0016045)5.06852509
10regulation of RIG-I signaling pathway (GO:0039535)4.95354996
11regulation of gamma-delta T cell activation (GO:0046643)4.91991028
12B cell receptor signaling pathway (GO:0050853)4.82274119
13macrophage activation involved in immune response (GO:0002281)4.80749602
14regulation of gamma-delta T cell differentiation (GO:0045586)4.71739514
15cellular extravasation (GO:0045123)4.69261782
16regulation of B cell receptor signaling pathway (GO:0050855)4.69258936
17leukocyte aggregation (GO:0070486)4.51939469
18detection of external biotic stimulus (GO:0098581)4.48734012
19negative regulation of lymphocyte mediated immunity (GO:0002707)4.38260839
20interferon-gamma production (GO:0032609)4.37497627
21regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.32566431
22positive thymic T cell selection (GO:0045059)4.32528341
23negative regulation of interleukin-12 production (GO:0032695)4.27354609
24detection of molecule of bacterial origin (GO:0032490)4.26187619
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19057757
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19057757
27antigen processing and presentation of endogenous antigen (GO:0019883)4.19018780
28leukocyte migration involved in inflammatory response (GO:0002523)4.16148220
29NIK/NF-kappaB signaling (GO:0038061)4.14506939
30positive regulation of B cell differentiation (GO:0045579)4.13513563
31regulation of interferon-beta biosynthetic process (GO:0045357)4.12799517
32microglial cell activation (GO:0001774)4.03444100
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.97502433
34response to host immune response (GO:0052572)3.97502433
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.95752641
36B cell proliferation (GO:0042100)3.95715262
37detection of biotic stimulus (GO:0009595)3.94887751
38regulation of B cell differentiation (GO:0045577)3.93630317
39positive T cell selection (GO:0043368)3.88395306
40immunoglobulin mediated immune response (GO:0016064)3.87671423
41negative regulation of leukocyte mediated immunity (GO:0002704)3.87670986
42neutrophil mediated immunity (GO:0002446)3.84699643
43regulation of isotype switching to IgG isotypes (GO:0048302)3.84447098
44regulation of mast cell degranulation (GO:0043304)3.81847463
45negative T cell selection (GO:0043383)3.78423186
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.77079384
47regulation of histone H3-K27 methylation (GO:0061085)3.73122407
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72347495
49negative regulation of T cell mediated immunity (GO:0002710)3.70793311
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.70786005
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.70765670
52negative regulation of cell killing (GO:0031342)3.70765670
53macrophage activation (GO:0042116)3.68828129
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.67613567
55response to host (GO:0075136)3.67613567
56response to host defenses (GO:0052200)3.67613567
57myeloid cell activation involved in immune response (GO:0002275)3.64971988
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.64505732
59negative regulation of erythrocyte differentiation (GO:0045647)3.63525848
60negative thymic T cell selection (GO:0045060)3.62406395
61T cell migration (GO:0072678)3.61712339
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.59614040
63response to muramyl dipeptide (GO:0032495)3.58310270
64antigen processing and presentation via MHC class Ib (GO:0002475)3.54627086
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52699979
66regulation of mast cell activation involved in immune response (GO:0033006)3.52104275
67T cell homeostasis (GO:0043029)3.51720681
68cellular response to interleukin-15 (GO:0071350)3.50232403
69regulation of interleukin-12 biosynthetic process (GO:0045075)3.49188349
70regulation of T cell receptor signaling pathway (GO:0050856)3.47657860
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.47550073
72negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.46395530
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.45812806
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.42720587
75positive regulation of DNA recombination (GO:0045911)3.42241956
76antigen receptor-mediated signaling pathway (GO:0050851)3.42114687
77regulation of leukocyte degranulation (GO:0043300)3.40823889
78positive regulation of mast cell activation (GO:0033005)3.39724949
79T cell selection (GO:0045058)3.36922316
80negative regulation of phagocytosis (GO:0050765)3.35759098
81cellular response to zinc ion (GO:0071294)3.33733518
82B cell homeostasis (GO:0001782)3.33207561
83type I interferon signaling pathway (GO:0060337)3.30713223
84cellular response to type I interferon (GO:0071357)3.30713223
85response to type I interferon (GO:0034340)3.30309252
86regulation of mast cell activation (GO:0033003)3.30246721
87positive regulation of isotype switching (GO:0045830)3.29925923
88CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.26194485
89regulation of T cell tolerance induction (GO:0002664)3.26165345
90regulation of tolerance induction (GO:0002643)3.26150140
91leukocyte degranulation (GO:0043299)3.25232699
92defense response to protozoan (GO:0042832)3.25051099
93thymic T cell selection (GO:0045061)3.24818410
94response to interleukin-15 (GO:0070672)3.23851928
95myeloid leukocyte mediated immunity (GO:0002444)3.23752591
96production of molecular mediator involved in inflammatory response (GO:0002532)3.22306053
97N-acetylneuraminate metabolic process (GO:0006054)3.21951516
98positive regulation of B cell proliferation (GO:0030890)3.19317559
99lymphocyte homeostasis (GO:0002260)3.17646379
100positive regulation of B cell activation (GO:0050871)3.16909180
101regulation of T cell mediated cytotoxicity (GO:0001914)3.12290363
102T cell lineage commitment (GO:0002360)3.09995840
103positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09334480
104response to protozoan (GO:0001562)3.08932641
105neutrophil activation (GO:0042119)3.07642764
106negative regulation of interleukin-6 production (GO:0032715)3.06677326
107neutrophil activation involved in immune response (GO:0002283)3.06527719
108regulation of alpha-beta T cell proliferation (GO:0046640)3.05384809
109negative regulation of T-helper cell differentiation (GO:0045623)3.04810665
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04810665
111germinal center formation (GO:0002467)3.04429951
112positive regulation of granulocyte differentiation (GO:0030854)3.03142722
113regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02890209
114negative regulation of innate immune response (GO:0045824)3.02494141
115mature B cell differentiation (GO:0002335)3.00655730
116B cell mediated immunity (GO:0019724)2.99903387
117negative regulation of T cell receptor signaling pathway (GO:0050860)2.99632994
118regulation of regulated secretory pathway (GO:1903305)2.98597654
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98311321
120positive regulation of interleukin-2 production (GO:0032743)2.97886473
121response to peptidoglycan (GO:0032494)2.96425124
122regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95400630
123positive regulation of humoral immune response (GO:0002922)2.95159477
124positive regulation of mast cell degranulation (GO:0043306)2.94343447
125positive regulation of mast cell activation involved in immune response (GO:0033008)2.94343447
126regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93926054
127regulation of natural killer cell mediated immunity (GO:0002715)2.93926054
128tolerance induction (GO:0002507)2.91808760
129negative regulation of type 2 immune response (GO:0002829)2.90272911
130T cell receptor signaling pathway (GO:0050852)2.88302341
131regulation of B cell proliferation (GO:0030888)2.87789510
132regulation of regulatory T cell differentiation (GO:0045589)2.84466371
133tRNA methylation (GO:0030488)2.82664354
134regulation of isotype switching (GO:0045191)2.81210348
135leukocyte homeostasis (GO:0001776)2.78536585
136activated T cell proliferation (GO:0050798)2.77717026
137alpha-beta T cell differentiation involved in immune response (GO:0002293)2.76407512
138alpha-beta T cell activation involved in immune response (GO:0002287)2.76407512
139T cell differentiation involved in immune response (GO:0002292)2.76407512
140lymphocyte proliferation (GO:0046651)2.74868788
141granulocyte activation (GO:0036230)2.71828776
142superoxide anion generation (GO:0042554)2.71035597
143regulation of B cell activation (GO:0050864)2.69598685
144T-helper cell differentiation (GO:0042093)2.69360356
145CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.69360356
146positive regulation of B cell mediated immunity (GO:0002714)2.67237637
147positive regulation of immunoglobulin mediated immune response (GO:0002891)2.67237637
148positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66598646
149lymphoid progenitor cell differentiation (GO:0002320)2.65852173
150mononuclear cell proliferation (GO:0032943)2.65735254
151regulation of germinal center formation (GO:0002634)2.64496597
152positive regulation of interferon-alpha production (GO:0032727)2.63878297
153mast cell activation (GO:0045576)2.63464709
154respiratory burst (GO:0045730)2.61405986
155negative regulation of execution phase of apoptosis (GO:1900118)2.60642690
156myeloid dendritic cell activation (GO:0001773)2.60515810
157B cell activation (GO:0042113)2.58358603
158regulation of interleukin-2 biosynthetic process (GO:0045076)2.56417836
159regulation of interleukin-2 production (GO:0032663)2.54130411
160immune response-activating cell surface receptor signaling pathway (GO:0002429)2.53938925
161interferon-gamma-mediated signaling pathway (GO:0060333)2.53528515
162regulation of necroptotic process (GO:0060544)2.53450498
163regulation of respiratory burst (GO:0060263)2.52676312
164regulation of interferon-alpha production (GO:0032647)2.51945011
165regulation of B cell mediated immunity (GO:0002712)2.49372167
166regulation of immunoglobulin production (GO:0002637)2.49363525
167alpha-beta T cell activation (GO:0046631)2.48544733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.43109504
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.64238766
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.31940426
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26947945
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.78415437
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18197247
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18066784
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90671198
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83905815
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.71199260
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61933680
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60532067
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.54491298
14RUNX_20019798_ChIP-Seq_JUKART_Human2.53039245
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45219031
16SCL_19346495_ChIP-Seq_HPC-7_Human2.38880691
17E2F7_22180533_ChIP-Seq_HELA_Human2.32655482
18GATA1_22025678_ChIP-Seq_K562_Human2.31718307
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.28943610
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28335302
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24282150
22* SPI1_23547873_ChIP-Seq_NB4_Human2.20193728
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.18410217
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14486948
25CIITA_25753668_ChIP-Seq_RAJI_Human2.11810651
26* MYB_26560356_Chip-Seq_TH2_Human2.11642802
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06894217
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03085523
29* MYB_26560356_Chip-Seq_TH1_Human2.00785357
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93468796
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.93289648
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92115024
33KDM2B_26808549_Chip-Seq_DND41_Human1.90837861
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.86139178
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85187736
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82301941
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78303588
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77446728
39* MYC_22102868_ChIP-Seq_BL_Human1.75649701
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74796283
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74176501
42* MAF_26560356_Chip-Seq_TH1_Human1.73000841
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.72559974
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.72449155
45VDR_23849224_ChIP-Seq_CD4+_Human1.69127113
46VDR_21846776_ChIP-Seq_THP-1_Human1.67702795
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67126520
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.66892170
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.66229069
50* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63491668
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.62973115
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58797755
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57970956
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57699283
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54449310
56* VDR_24763502_ChIP-Seq_THP-1_Human1.53675241
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51282420
58* UTX_26944678_Chip-Seq_JUKART_Human1.50116225
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49966552
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48684398
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48644233
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48368531
63GATA3_27048872_Chip-Seq_THYMUS_Human1.46341376
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45753034
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45405793
66* ELK3_25401928_ChIP-Seq_HUVEC_Human1.43633183
67LXR_22292898_ChIP-Seq_THP-1_Human1.42734607
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42295218
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41683082
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38721902
71* SPI1_23127762_ChIP-Seq_K562_Human1.37474190
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36294327
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34154312
74GATA3_26560356_Chip-Seq_TH2_Human1.33728901
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.33678548
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.33188930
77* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32329322
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32024940
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32024402
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31718926
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.30845450
82PU_27001747_Chip-Seq_BMDM_Mouse1.30097751
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28536273
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26225916
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25594724
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24641917
87GATA1_19941826_ChIP-Seq_K562_Human1.23938564
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23271959
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23256594
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22846071
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22651629
92BCL6_27268052_Chip-Seq_Bcells_Human1.22053074
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21245066
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.21189206
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20399074
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19000624
97ELK1_19687146_ChIP-ChIP_HELA_Human1.18512244
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16582213
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.16474623
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13706081
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12389073
102TFEB_21752829_ChIP-Seq_HELA_Human1.10646544
103* BCOR_27268052_Chip-Seq_Bcells_Human1.10286979
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09998208
105* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08011039
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07030538
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06433907
108E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04072934
109MAF_26560356_Chip-Seq_TH2_Human1.03501426
110* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02837452
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02714627
112CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01258192
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01176767
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.99431445
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98065241
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97594061
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97420610
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97091406
119NCOR1_26117541_ChIP-Seq_K562_Human0.97067537
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96148631
121* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95979396
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.94710911
123YY1_21170310_ChIP-Seq_MESCs_Mouse0.94274936
124GATA2_19941826_ChIP-Seq_K562_Human0.93778718
125* TCF7_22412390_ChIP-Seq_EML_Mouse0.91723207
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.90756939
127SPI1_20517297_ChIP-Seq_HL60_Human0.89591647
128NMYC_18555785_Chip-Seq_ESCs_Mouse0.89574742
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.89310562
130VDR_24787735_ChIP-Seq_THP-1_Human0.89274286
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88994981
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88815110
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88160161
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87606186
135PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87279197
136IRF1_19129219_ChIP-ChIP_H3396_Human0.87233116
137* P68_20966046_ChIP-Seq_HELA_Human0.81438848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.92088005
2MP0005671_abnormal_response_to3.54275545
3MP0005387_immune_system_phenotype3.21254480
4MP0001790_abnormal_immune_system3.21254480
5MP0001800_abnormal_humoral_immune3.16038779
6MP0003763_abnormal_thymus_physiology3.11182427
7MP0000685_abnormal_immune_system3.09025197
8MP0005075_abnormal_melanosome_morpholog2.73574076
9MP0002452_abnormal_antigen_presenting2.63272941
10MP0009785_altered_susceptibility_to2.60933414
11MP0005000_abnormal_immune_tolerance2.55047326
12MP0002723_abnormal_immune_serum2.52305165
13MP0004381_abnormal_hair_follicle2.50285611
14MP0002420_abnormal_adaptive_immunity2.49028177
15MP0001819_abnormal_immune_cell2.45947968
16MP0003300_gastrointestinal_ulcer2.30287485
17MP0002398_abnormal_bone_marrow2.27215100
18MP0003191_abnormal_cellular_cholesterol2.23916028
19MP0002396_abnormal_hematopoietic_system2.22316393
20MP0009333_abnormal_splenocyte_physiolog2.18864446
21MP0002419_abnormal_innate_immunity2.14164379
22MP0000716_abnormal_immune_system2.12778421
23MP0005025_abnormal_response_to2.11247861
24MP0003693_abnormal_embryo_hatching2.05883624
25MP0000689_abnormal_spleen_morphology2.01334230
26MP0003183_abnormal_peptide_metabolism1.99171590
27MP0003866_abnormal_defecation1.96500942
28MP0002148_abnormal_hypersensitivity_rea1.93330909
29MP0002166_altered_tumor_susceptibility1.90890255
30MP0000015_abnormal_ear_pigmentation1.89418593
31MP0009278_abnormal_bone_marrow1.89203742
32MP0002722_abnormal_immune_system1.84220115
33MP0000703_abnormal_thymus_morphology1.81881676
34MP0008260_abnormal_autophagy1.79293802
35MP0004510_myositis1.78008879
36MP0003436_decreased_susceptibility_to1.77617573
37MP0001873_stomach_inflammation1.70990946
38MP0002429_abnormal_blood_cell1.69511372
39MP0003172_abnormal_lysosome_physiology1.62723449
40MP0002405_respiratory_system_inflammati1.56572333
41MP0010386_abnormal_urinary_bladder1.52995379
42MP0000569_abnormal_digit_pigmentation1.52703981
43MP0002933_joint_inflammation1.51993131
44MP0008058_abnormal_DNA_repair1.47257255
45MP0001845_abnormal_inflammatory_respons1.45717286
46MP0002693_abnormal_pancreas_physiology1.44713172
47MP0005409_darkened_coat_color1.41972159
48MP0010155_abnormal_intestine_physiology1.41941204
49MP0005174_abnormal_tail_pigmentation1.40340002
50MP0002006_tumorigenesis1.40316582
51MP0005464_abnormal_platelet_physiology1.40061733
52MP0001545_abnormal_hematopoietic_system1.39363930
53MP0005397_hematopoietic_system_phenotyp1.39363930
54MP0004883_abnormal_blood_vessel1.37373129
55MP0004808_abnormal_hematopoietic_stem1.36648963
56MP0008057_abnormal_DNA_replication1.36076735
57MP0001851_eye_inflammation1.33659009
58MP0001853_heart_inflammation1.32341186
59MP0002876_abnormal_thyroid_physiology1.31438890
60MP0001188_hyperpigmentation1.29675867
61MP0003724_increased_susceptibility_to1.26850640
62MP0001986_abnormal_taste_sensitivity1.25425908
63MP0002009_preneoplasia1.24131887
64MP0005310_abnormal_salivary_gland1.20371384
65MP0005645_abnormal_hypothalamus_physiol1.19412892
66MP0000490_abnormal_crypts_of1.18518098
67MP0003111_abnormal_nucleus_morphology1.18437248
68MP0004947_skin_inflammation1.18186686
69MP0003075_altered_response_to1.09864368
70MP0005379_endocrine/exocrine_gland_phen1.08719594
71MP0002095_abnormal_skin_pigmentation1.07314279
72MP0003879_abnormal_hair_cell1.06691292
73MP0006082_CNS_inflammation1.06583027
74MP0005164_abnormal_response_to1.04052147
75MP0003303_peritoneal_inflammation1.00633201
76MP0002928_abnormal_bile_duct1.00358381
77MP0003690_abnormal_glial_cell0.99322028
78MP0000465_gastrointestinal_hemorrhage0.99138964
79MP0002163_abnormal_gland_morphology0.98642205
80MP0008469_abnormal_protein_level0.98109650
81MP0002138_abnormal_hepatobiliary_system0.97563252
82MP0010094_abnormal_chromosome_stability0.96569904
83MP0005058_abnormal_lysosome_morphology0.96236609
84MP0003943_abnormal_hepatobiliary_system0.93059935
85MP0006292_abnormal_olfactory_placode0.91322858
86MP0005451_abnormal_body_composition0.90859539
87MP0005166_decreased_susceptibility_to0.90337493
88MP0005390_skeleton_phenotype0.89712281
89MP0003868_abnormal_feces_composition0.88284519
90MP0000372_irregular_coat_pigmentation0.88092995
91MP0001663_abnormal_digestive_system0.84064573
92MP0009840_abnormal_foam_cell0.81568737
93MP0002132_abnormal_respiratory_system0.81242431
94MP0009763_increased_sensitivity_to0.81188563
95MP0001186_pigmentation_phenotype0.80555355
96MP0003077_abnormal_cell_cycle0.79534818
97MP0004130_abnormal_muscle_cell0.77715076
98MP0000371_diluted_coat_color0.76841781
99MP0002638_abnormal_pupillary_reflex0.75413356
100MP0002998_abnormal_bone_remodeling0.75370183
101MP0001764_abnormal_homeostasis0.75366147
102MP0003448_altered_tumor_morphology0.74541848
103MP0003045_fibrosis0.73721007
104MP0001944_abnormal_pancreas_morphology0.73228747
105MP0003656_abnormal_erythrocyte_physiolo0.73110835
106MP0008004_abnormal_stomach_pH0.72273151
107MP0002019_abnormal_tumor_incidence0.69945664
108MP0002075_abnormal_coat/hair_pigmentati0.68380233
109MP0005083_abnormal_biliary_tract0.67511511
110MP0000858_altered_metastatic_potential0.67031601
111MP0000604_amyloidosis0.66589744
112MP0000013_abnormal_adipose_tissue0.66315040
113MP0000343_altered_response_to0.65265693
114MP0009765_abnormal_xenobiotic_induced0.64772316
115MP0003795_abnormal_bone_structure0.64752337
116MP0002277_abnormal_respiratory_mucosa0.64271300
117MP0000249_abnormal_blood_vessel0.63475248
118MP0002168_other_aberrant_phenotype0.62683299
119MP0003787_abnormal_imprinting0.62590197
120MP0004782_abnormal_surfactant_physiolog0.62295595
121MP0008874_decreased_physiological_sensi0.61592947
122MP0001533_abnormal_skeleton_physiology0.60202321
123MP0003828_pulmonary_edema0.60201367
124MP0003786_premature_aging0.60009709
125MP0009764_decreased_sensitivity_to0.57851567
126MP0005076_abnormal_cell_differentiation0.55987016
127MP0005388_respiratory_system_phenotype0.53018223
128MP0002133_abnormal_respiratory_system0.53018223
129MP0001958_emphysema0.52197907
130MP0005319_abnormal_enzyme/_coenzyme0.51862285
131MP0003806_abnormal_nucleotide_metabolis0.50655027
132MP0002332_abnormal_exercise_endurance0.49742038
133MP0003221_abnormal_cardiomyocyte_apopto0.49403884
134MP0005377_hearing/vestibular/ear_phenot0.48768518

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.45475741
2Agammaglobulinemia (HP:0004432)4.96656943
3Panhypogammaglobulinemia (HP:0003139)4.50105134
4Gastrointestinal infarctions (HP:0005244)4.46968017
5Stomatitis (HP:0010280)4.38677015
6Recurrent abscess formation (HP:0002722)4.14435476
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.13188329
8Meningitis (HP:0001287)3.97731738
9IgM deficiency (HP:0002850)3.92292785
10Recurrent fungal infections (HP:0002841)3.88933360
11Increased IgE level (HP:0003212)3.86109595
12Spontaneous hematomas (HP:0007420)3.80168038
13Recurrent viral infections (HP:0004429)3.78499799
14Eczematoid dermatitis (HP:0000976)3.77757952
15Keratoconjunctivitis sicca (HP:0001097)3.71683512
16Recurrent bronchitis (HP:0002837)3.64519955
17Recurrent bacterial skin infections (HP:0005406)3.62585083
18Recurrent cutaneous fungal infections (HP:0011370)3.60970914
19Chronic mucocutaneous candidiasis (HP:0002728)3.60970914
20T lymphocytopenia (HP:0005403)3.60686048
21Abnormality of B cell number (HP:0010975)3.56232327
22B lymphocytopenia (HP:0010976)3.56232327
23Mediastinal lymphadenopathy (HP:0100721)3.53842110
24IgG deficiency (HP:0004315)3.53248684
25Hypochromic microcytic anemia (HP:0004840)3.50218720
26Abnormality of T cell number (HP:0011839)3.49942211
27Thyroiditis (HP:0100646)3.46306660
28Chest pain (HP:0100749)3.45840300
29Keratoconjunctivitis (HP:0001096)3.45576112
30Chronic diarrhea (HP:0002028)3.43175130
31Gastrointestinal stroma tumor (HP:0100723)3.42396211
32Abnormality of T cells (HP:0002843)3.41136050
33Urticaria (HP:0001025)3.37643029
34Hypochromic anemia (HP:0001931)3.32551197
35Chronic otitis media (HP:0000389)3.30854943
36Severe combined immunodeficiency (HP:0004430)3.29255593
37Abnormality of T cell physiology (HP:0011840)3.17673068
38Abnormality of the fingertips (HP:0001211)3.17169969
39Hemoptysis (HP:0002105)3.16825869
40Lymphopenia (HP:0001888)3.04927336
41Episodic fever (HP:0001954)2.99220160
42Chronic sinusitis (HP:0011109)2.97437236
43Recurrent sinusitis (HP:0011108)2.97077909
44Gingivitis (HP:0000230)2.94790683
45Chronic obstructive pulmonary disease (HP:0006510)2.94106392
46Obstructive lung disease (HP:0006536)2.94106392
47Epistaxis (HP:0000421)2.91797853
48Increased IgM level (HP:0003496)2.91587066
49Pustule (HP:0200039)2.91090285
50Vasculitis (HP:0002633)2.90719757
51Gingival bleeding (HP:0000225)2.89966312
52Peritonitis (HP:0002586)2.89245362
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.86771322
54Recurrent skin infections (HP:0001581)2.85937162
55Arterial thrombosis (HP:0004420)2.83191741
56Cellulitis (HP:0100658)2.82472738
57Abnormality of eosinophils (HP:0001879)2.80407001
58Hypoplasia of the thymus (HP:0000778)2.78874549
59Pulmonary embolism (HP:0002204)2.77601922
60Inflammation of the large intestine (HP:0002037)2.76430575
61IgA deficiency (HP:0002720)2.72745079
62Recurrent pneumonia (HP:0006532)2.70234248
63Abnormal hair whorl (HP:0010721)2.69922294
64Amyloidosis (HP:0011034)2.67886927
65Combined immunodeficiency (HP:0005387)2.64215189
66Lymphoma (HP:0002665)2.63236549
67Neutropenia (HP:0001875)2.62457089
68Encephalitis (HP:0002383)2.61937776
69Anorexia (HP:0002039)2.61817956
70Abnormality of macrophages (HP:0004311)2.60936440
71Gastrointestinal inflammation (HP:0004386)2.57030024
72Eosinophilia (HP:0001880)2.56819523
73Colitis (HP:0002583)2.51934880
74Cheilitis (HP:0100825)2.49308511
75Elevated erythrocyte sedimentation rate (HP:0003565)2.48122161
76Basal ganglia calcification (HP:0002135)2.45523193
77Abnormality of the pleura (HP:0002103)2.44495596
78Petechiae (HP:0000967)2.44314461
79Microcytic anemia (HP:0001935)2.42946272
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42841366
81Recurrent gram-negative bacterial infections (HP:0005420)2.40738569
82Abnormality of the peritoneum (HP:0002585)2.40471044
83Granulocytopenia (HP:0001913)2.35570395
84Microvesicular hepatic steatosis (HP:0001414)2.33603354
85Recurrent lower respiratory tract infections (HP:0002783)2.31658822
86Gangrene (HP:0100758)2.29052557
87Retrobulbar optic neuritis (HP:0100654)2.26910557
88Optic neuritis (HP:0100653)2.26910557
89Leukopenia (HP:0001882)2.21482625
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21123804
91Abnormality of DNA repair (HP:0003254)2.19295630
92Viral hepatitis (HP:0006562)2.18540102
93Osteomyelitis (HP:0002754)2.18460399
94Mitral stenosis (HP:0001718)2.17800273
95Chromsome breakage (HP:0040012)2.17433786
96Type I transferrin isoform profile (HP:0003642)2.16972722
97Emphysema (HP:0002097)2.16325603
98Myositis (HP:0100614)2.15630569
99Skin ulcer (HP:0200042)2.14220624
100Abnormality of the endocardium (HP:0004306)2.12732590
101Hepatosplenomegaly (HP:0001433)2.11154169
102Abnormality of liposaccharide metabolism (HP:0010968)2.09822827
103Abnormality of glycosphingolipid metabolism (HP:0004343)2.09822827
104Abnormality of glycolipid metabolism (HP:0010969)2.09822827
105Vacuolated lymphocytes (HP:0001922)2.07914040
106Increased serum ferritin (HP:0003281)2.07867172
107Reduced antithrombin III activity (HP:0001976)2.07695333
108Renal cortical cysts (HP:0000803)2.06571734
109Glomerulopathy (HP:0100820)2.06387280
110Leukocytosis (HP:0001974)2.05754594
111Purpura (HP:0000979)2.05480264
112Abnormality of iron homeostasis (HP:0011031)2.02127492
113Bronchitis (HP:0012387)2.01201185
114Acne (HP:0001061)1.99247662
115Hypoproteinemia (HP:0003075)1.99061060
116Increased cerebral lipofuscin (HP:0011813)1.98516631
117Sepsis (HP:0100806)1.96546370
118Slow saccadic eye movements (HP:0000514)1.96181208
119Restrictive lung disease (HP:0002091)1.96019000
120Abnormal platelet volume (HP:0011876)1.95320269
121Verrucae (HP:0200043)1.95117952
122Papilloma (HP:0012740)1.95117952
123Vertigo (HP:0002321)1.95040987
124Acute hepatic failure (HP:0006554)1.94089381
125Prolonged bleeding time (HP:0003010)1.93940867
126Keratitis (HP:0000491)1.93650727
127Papilledema (HP:0001085)1.93282981
128Autoimmune thrombocytopenia (HP:0001973)1.92531642
129Abnormality of the pericardium (HP:0001697)1.92294735
130Pulmonary infiltrates (HP:0002113)1.90190893
131Skin rash (HP:0000988)1.89506939
132Hypergammaglobulinemia (HP:0010702)1.86804319
133Clubbing of toes (HP:0100760)1.86301143
134Premature loss of primary teeth (HP:0006323)1.85727822
135Decreased circulating renin level (HP:0003351)1.84036893
1363-Methylglutaconic aciduria (HP:0003535)1.83992973
137Periodontitis (HP:0000704)1.82505628
138Abnormality of the prostate (HP:0008775)1.82135436
139Metaphyseal cupping (HP:0003021)1.80827699
140Recurrent otitis media (HP:0000403)1.78631189
141Entropion (HP:0000621)1.77795060
142Prolonged neonatal jaundice (HP:0006579)1.76535561
143Stomach cancer (HP:0012126)1.74860038
144Birth length less than 3rd percentile (HP:0003561)1.74309767
145Febrile seizures (HP:0002373)1.73076805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.34214322
2TXK3.65500661
3IRAK33.19624259
4ERN13.00358018
5MAP3K142.83163738
6IRAK42.60830849
7RIPK42.20267375
8ZAP702.19158510
9INSRR2.16215191
10JAK32.15312395
11EPHB12.04384354
12ZAK1.88181749
13MAP3K131.85420954
14BUB11.84543285
15IKBKE1.81556956
16SYK1.80763016
17EIF2AK31.80212079
18TEC1.78532184
19NLK1.73329674
20TAOK11.72652125
21MAP3K31.72145528
22STK161.71349843
23IKBKB1.68120017
24BTK1.61990411
25MAP3K111.57814816
26FGR1.56322878
27MAP3K121.54779942
28TYK21.53831134
29TNIK1.39494392
30JAK21.37344659
31BLK1.35627006
32SIK31.34638763
33CASK1.31046278
34JAK11.30600308
35YES11.30346933
36MAPK151.30054824
37ITK1.28535622
38MAP3K11.28380136
39KIT1.27018942
40TRIB31.26460626
41CLK11.24365238
42LCK1.23944215
43EIF2AK21.23248983
44GRK61.22191586
45TAOK31.20960660
46HCK1.20955876
47CHUK1.18008362
48MARK21.17623048
49PIM11.15806451
50LYN1.15803501
51FES1.15268799
52MARK31.14626743
53SIK21.13803304
54KSR21.12228172
55PTK61.09438194
56EPHA21.05492984
57MAP3K101.04138900
58PIK3CG1.02652441
59SGK21.00170602
60MAP3K70.97696276
61TSSK60.97458382
62TNK20.96700758
63TBK10.93955286
64SGK30.93066595
65CSF1R0.92847302
66BMPR20.92464938
67HIPK20.90220122
68PASK0.90206010
69MAPK70.89562352
70CSK0.89377810
71PDK10.89260862
72SRPK10.88289570
73CAMKK20.86331776
74WEE10.82815423
75MAP3K60.80931569
76STK100.80359596
77IRAK20.80311479
78MATK0.79968606
79SMG10.79626865
80TLK10.78574381
81BRSK20.78164663
82CCNB10.77552112
83PDPK10.77298283
84PTK2B0.76712297
85MAPK120.76346066
86PIM20.75728385
87ACVR1B0.72959089
88TESK20.71863961
89ARAF0.70130956
90TAOK20.69129944
91BRD40.68885688
92CDC42BPA0.68295854
93LRRK20.67692730
94STK240.67410734
95FGFR40.65782555
96SIK10.65642908
97DYRK1B0.65256940
98FGFR30.65255493
99PRKCQ0.63872659
100FYN0.63744980
101CDK190.63265636
102TGFBR20.62915029
103STK110.62791176
104STK40.60486801
105MAP2K40.60435212
106PNCK0.60020330
107GRK10.59883969
108CDK30.59033070
109FRK0.58852198
110DAPK20.57525061
111MAP3K20.54707521
112STK380.53648755
113MAP2K60.53068306
114RPS6KA50.52535500
115MAPK40.51882914
116VRK10.51791583
117RPS6KL10.51605923
118RPS6KC10.51605923
119RET0.51081085
120NME20.49560370
121EPHA30.47750804
122BRAF0.47283441
123MKNK20.46663765
124MELK0.46294054
125PRKCH0.44806457
126ADRBK20.44755362
127CAMKK10.44502807
128NUAK10.43654522
129CDK40.43455916
130PRPF4B0.43410196
131PRKD20.41884038
132ATR0.40715755
133PRKCD0.40296208
134CAMK10.40023183
135MAP3K50.39691590
136BRSK10.39561403
137RPS6KA60.38710217
138MAP2K70.38482808
139GRK70.37903693
140WNK10.37115444
141RAF10.36720043
142PKN20.36401406
143MAPKAPK20.35972616
144IRAK10.35353727
145PRKCI0.33360587
146MAP2K30.33180672
147RPS6KB10.32979400
148CDK120.32060079
149MAP2K20.29569464
150PRKCZ0.28863761

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.72799058
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.95582236
3Staphylococcus aureus infection_Homo sapiens_hsa051502.76243276
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.66921091
5Allograft rejection_Homo sapiens_hsa053302.59288331
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.55349616
7B cell receptor signaling pathway_Homo sapiens_hsa046622.51151870
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.33552477
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08649471
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04377727
11Graft-versus-host disease_Homo sapiens_hsa053321.98362166
12T cell receptor signaling pathway_Homo sapiens_hsa046601.92968706
13Hematopoietic cell lineage_Homo sapiens_hsa046401.91601796
14Measles_Homo sapiens_hsa051621.87498772
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71860482
16Type I diabetes mellitus_Homo sapiens_hsa049401.69622235
17Antigen processing and presentation_Homo sapiens_hsa046121.69127110
18Leishmaniasis_Homo sapiens_hsa051401.68685998
19Non-homologous end-joining_Homo sapiens_hsa034501.67707479
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61904724
21Autoimmune thyroid disease_Homo sapiens_hsa053201.61041332
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57997189
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57651919
24* Regulation of autophagy_Homo sapiens_hsa041401.56343977
25Osteoclast differentiation_Homo sapiens_hsa043801.52398141
26Protein export_Homo sapiens_hsa030601.46627187
27Base excision repair_Homo sapiens_hsa034101.46483476
28Asthma_Homo sapiens_hsa053101.46280754
29Herpes simplex infection_Homo sapiens_hsa051681.41203287
30Other glycan degradation_Homo sapiens_hsa005111.40664362
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34251639
32Non-small cell lung cancer_Homo sapiens_hsa052231.28827466
33Homologous recombination_Homo sapiens_hsa034401.27658176
34Phagosome_Homo sapiens_hsa041451.27375651
35Fanconi anemia pathway_Homo sapiens_hsa034601.22671134
36Proteasome_Homo sapiens_hsa030501.20273807
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13950604
38Rheumatoid arthritis_Homo sapiens_hsa053231.10242497
39Epstein-Barr virus infection_Homo sapiens_hsa051691.06460058
40Chemokine signaling pathway_Homo sapiens_hsa040621.02619160
41VEGF signaling pathway_Homo sapiens_hsa043701.01597085
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01341886
43Chronic myeloid leukemia_Homo sapiens_hsa052201.00784656
44Pancreatic cancer_Homo sapiens_hsa052121.00483005
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.97914482
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.97902703
47Tuberculosis_Homo sapiens_hsa051520.95783464
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91862639
49Apoptosis_Homo sapiens_hsa042100.87342643
50Influenza A_Homo sapiens_hsa051640.84476791
51Acute myeloid leukemia_Homo sapiens_hsa052210.83662745
52Hepatitis B_Homo sapiens_hsa051610.83078817
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82980020
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82792976
55Inositol phosphate metabolism_Homo sapiens_hsa005620.82082046
56Notch signaling pathway_Homo sapiens_hsa043300.81009468
57Renal cell carcinoma_Homo sapiens_hsa052110.78749381
58TNF signaling pathway_Homo sapiens_hsa046680.78581887
59Endocytosis_Homo sapiens_hsa041440.78013149
60Lysosome_Homo sapiens_hsa041420.77924957
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.77846864
62DNA replication_Homo sapiens_hsa030300.77820778
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77508909
64Circadian rhythm_Homo sapiens_hsa047100.74502772
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74040770
66Toxoplasmosis_Homo sapiens_hsa051450.73338036
67Dorso-ventral axis formation_Homo sapiens_hsa043200.72847656
68Choline metabolism in cancer_Homo sapiens_hsa052310.71642134
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71562321
70Insulin secretion_Homo sapiens_hsa049110.71442883
71Nicotine addiction_Homo sapiens_hsa050330.70374746
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69428679
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.69383899
74GnRH signaling pathway_Homo sapiens_hsa049120.69214800
75Mismatch repair_Homo sapiens_hsa034300.68739451
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68150376
77Sphingolipid metabolism_Homo sapiens_hsa006000.67960836
78Type II diabetes mellitus_Homo sapiens_hsa049300.66311962
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.66155105
80Pyrimidine metabolism_Homo sapiens_hsa002400.65875207
81Malaria_Homo sapiens_hsa051440.65190792
82Basal transcription factors_Homo sapiens_hsa030220.65120412
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64188449
84RNA polymerase_Homo sapiens_hsa030200.63086891
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62639746
86ABC transporters_Homo sapiens_hsa020100.62386129
87Endometrial cancer_Homo sapiens_hsa052130.62095396
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61866433
89Morphine addiction_Homo sapiens_hsa050320.60939292
90mTOR signaling pathway_Homo sapiens_hsa041500.60246821
91Amoebiasis_Homo sapiens_hsa051460.58931420
92Nucleotide excision repair_Homo sapiens_hsa034200.57958174
93Insulin resistance_Homo sapiens_hsa049310.56177423
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55923922
95Shigellosis_Homo sapiens_hsa051310.55327097
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54474349
97Colorectal cancer_Homo sapiens_hsa052100.54083317
98Legionellosis_Homo sapiens_hsa051340.53566939
99FoxO signaling pathway_Homo sapiens_hsa040680.51917388
100HIF-1 signaling pathway_Homo sapiens_hsa040660.51259039
101Spliceosome_Homo sapiens_hsa030400.50909038
102Platelet activation_Homo sapiens_hsa046110.48993647
103Hepatitis C_Homo sapiens_hsa051600.47895211
104HTLV-I infection_Homo sapiens_hsa051660.47605434
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.46207905
106Rap1 signaling pathway_Homo sapiens_hsa040150.45512354
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.45163473
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44603281
109ErbB signaling pathway_Homo sapiens_hsa040120.42786650
110Estrogen signaling pathway_Homo sapiens_hsa049150.41821784
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41807950
112Viral myocarditis_Homo sapiens_hsa054160.41788257
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41722558
114Prolactin signaling pathway_Homo sapiens_hsa049170.41201738
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41062809
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40312202
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39045153
118p53 signaling pathway_Homo sapiens_hsa041150.38883394
119Prostate cancer_Homo sapiens_hsa052150.37612797
120Purine metabolism_Homo sapiens_hsa002300.36976753
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36752710
122N-Glycan biosynthesis_Homo sapiens_hsa005100.36490965
123Pertussis_Homo sapiens_hsa051330.34705028
124African trypanosomiasis_Homo sapiens_hsa051430.34124025
125RNA degradation_Homo sapiens_hsa030180.33253418
126MAPK signaling pathway_Homo sapiens_hsa040100.32821347
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32465095
128Glioma_Homo sapiens_hsa052140.32105625
129Collecting duct acid secretion_Homo sapiens_hsa049660.30513750
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.30025416
131Viral carcinogenesis_Homo sapiens_hsa052030.28879818
132Salmonella infection_Homo sapiens_hsa051320.28200153
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27888574

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