ATG2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein required for autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.31925205
2polyketide metabolic process (GO:0030638)6.31925205
3doxorubicin metabolic process (GO:0044598)6.31925205
4histone H4-K5 acetylation (GO:0043981)4.71908151
5histone H4-K8 acetylation (GO:0043982)4.71908151
6interkinetic nuclear migration (GO:0022027)4.55216438
7histone H4-K12 acetylation (GO:0043983)4.40928638
8proline transport (GO:0015824)4.36694807
9maintenance of protein location in nucleus (GO:0051457)4.19138799
10histone H3-K36 demethylation (GO:0070544)4.09789327
11pre-miRNA processing (GO:0031054)4.08184012
12negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.05757233
13negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.99893054
14somite rostral/caudal axis specification (GO:0032525)3.99059549
15coenzyme catabolic process (GO:0009109)3.94364757
16histone H3-K9 demethylation (GO:0033169)3.94042389
17histone H4-K16 acetylation (GO:0043984)3.89428173
18mitochondrion distribution (GO:0048311)3.81606988
19protein targeting to Golgi (GO:0000042)3.77843361
20regulation of telomere maintenance via telomerase (GO:0032210)3.75888031
21aminoglycoside antibiotic metabolic process (GO:0030647)3.74403850
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.70498836
23nuclear pore complex assembly (GO:0051292)3.67416831
24regulation of ARF protein signal transduction (GO:0032012)3.66900847
25synaptic vesicle maturation (GO:0016188)3.62328410
26Golgi to endosome transport (GO:0006895)3.56864039
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.49998030
28negative regulation of cell cycle G2/M phase transition (GO:1902750)3.46720210
29nucleus localization (GO:0051647)3.46386178
30cerebellar granule cell differentiation (GO:0021707)3.42572332
31establishment of protein localization to Golgi (GO:0072600)3.40589983
32regulation of response to osmotic stress (GO:0047484)3.39928651
33retrograde transport, vesicle recycling within Golgi (GO:0000301)3.38754761
34positive regulation of histone deacetylation (GO:0031065)3.37741755
35nuclear pore organization (GO:0006999)3.34329523
36histone H3-K4 methylation (GO:0051568)3.34086716
37stress granule assembly (GO:0034063)3.31299862
38mitotic sister chromatid segregation (GO:0000070)3.22662168
39glutamate secretion (GO:0014047)3.22128589
40regulation of MHC class I biosynthetic process (GO:0045343)3.20567439
41histone lysine demethylation (GO:0070076)3.19994649
42cellular response to ethanol (GO:0071361)3.19981274
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19694614
44regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.14865944
45hormone catabolic process (GO:0042447)3.12990482
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.09663052
47histone demethylation (GO:0016577)3.08810340
48regulation of NFAT protein import into nucleus (GO:0051532)3.08413125
49establishment of nucleus localization (GO:0040023)3.06363774
50cellular modified amino acid catabolic process (GO:0042219)3.02085067
51peptidyl-threonine phosphorylation (GO:0018107)2.99320660
52regulation of histone H3-K27 methylation (GO:0061085)2.99040063
53sister chromatid segregation (GO:0000819)2.98029881
54negative regulation of erythrocyte differentiation (GO:0045647)2.97732161
55mitochondrion localization (GO:0051646)2.96943104
56striatum development (GO:0021756)2.94241203
57peptidyl-threonine modification (GO:0018210)2.93787676
58regulation of nuclear cell cycle DNA replication (GO:0033262)2.91236167
59regulation of RNA export from nucleus (GO:0046831)2.90124439
60protein localization to kinetochore (GO:0034501)2.89928261
61lipid translocation (GO:0034204)2.88292160
62phospholipid translocation (GO:0045332)2.88292160
63cytoplasmic mRNA processing body assembly (GO:0033962)2.88181441
64embryonic camera-type eye morphogenesis (GO:0048596)2.85061722
65regulation of cilium movement (GO:0003352)2.83623185
66heterochromatin organization (GO:0070828)2.82841815
67macroautophagy (GO:0016236)2.82418351
68chromatin assembly (GO:0031497)2.81389936
69negative regulation of telomerase activity (GO:0051974)2.79766813
70insulin-like growth factor receptor signaling pathway (GO:0048009)2.79574846
71negative regulation of potassium ion transmembrane transport (GO:1901380)2.77016590
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.75157591
73positive regulation of synapse maturation (GO:0090129)2.74943299
74negative regulation of dendrite morphogenesis (GO:0050774)2.73243707
75response to dietary excess (GO:0002021)2.71584428
76cerebellar Purkinje cell differentiation (GO:0021702)2.71097408
77histone H3-K4 trimethylation (GO:0080182)2.70294019
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.70023675
79protein K48-linked deubiquitination (GO:0071108)2.69870192
80phenol-containing compound catabolic process (GO:0019336)2.69500981
81definitive hemopoiesis (GO:0060216)2.69130688
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.68766447
83positive regulation of protein deacetylation (GO:0090312)2.67950751
84regulation of nucleobase-containing compound transport (GO:0032239)2.67235908
85neurotransmitter-gated ion channel clustering (GO:0072578)2.66762950
86NLS-bearing protein import into nucleus (GO:0006607)2.65946770
87regulation of telomere maintenance (GO:0032204)2.65032106
88monoubiquitinated protein deubiquitination (GO:0035520)2.64727071
89pore complex assembly (GO:0046931)2.64237563
90protein dealkylation (GO:0008214)2.63403514
91protein demethylation (GO:0006482)2.63403514
92rRNA transcription (GO:0009303)2.62039538
93neurotransmitter secretion (GO:0007269)2.60846856
94ventricular system development (GO:0021591)2.60360720
95regulation of synaptic vesicle exocytosis (GO:2000300)2.59714199
96receptor recycling (GO:0001881)2.57037525
97negative regulation of neurotransmitter secretion (GO:0046929)2.55627341
98intestinal epithelial cell development (GO:0060576)2.55383627
99muscle organ morphogenesis (GO:0048644)2.55087313
100peptidyl-lysine trimethylation (GO:0018023)2.52695943
101protein polyglutamylation (GO:0018095)2.51932485
102regulation of skeletal muscle cell differentiation (GO:2001014)2.51901376
103vocalization behavior (GO:0071625)2.51531308
104mitochondrion transport along microtubule (GO:0047497)2.51077851
105establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51077851
106positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.50392778
107vesicle transport along microtubule (GO:0047496)2.49155543
108positive regulation of Rap GTPase activity (GO:0032854)2.47886325
109L-amino acid import (GO:0043092)2.47514401
110negative regulation of histone methylation (GO:0031061)2.47033251
111epoxygenase P450 pathway (GO:0019373)2.46871307
112protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.46520587
113synaptic vesicle exocytosis (GO:0016079)2.45706365
114branching involved in mammary gland duct morphogenesis (GO:0060444)2.44961518
115negative regulation of inclusion body assembly (GO:0090084)2.44885301
116cerebral cortex development (GO:0021987)2.41901308
117tachykinin receptor signaling pathway (GO:0007217)2.41425054
118locomotory exploration behavior (GO:0035641)2.40908803
119regulation of gamma-delta T cell differentiation (GO:0045586)2.40851783
120negative regulation of epidermis development (GO:0045683)2.38601604
121positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37000685
122intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.36887826
123cell migration in hindbrain (GO:0021535)2.35737464
124cell differentiation in hindbrain (GO:0021533)2.34383073
125establishment of mitochondrion localization (GO:0051654)2.34078002
126regulation of glucose import in response to insulin stimulus (GO:2001273)2.33910388
127growth hormone receptor signaling pathway (GO:0060396)2.33278346
128regulation of Rap GTPase activity (GO:0032317)2.33196664
129histone lysine methylation (GO:0034968)2.31362448
130glycolytic process (GO:0006096)2.30813922
131protein localization to cilium (GO:0061512)2.30089175
132regulation of protein polyubiquitination (GO:1902914)2.29920971
133regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29422952
134negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.28787491
135regulation of synaptic vesicle transport (GO:1902803)2.28171362
136apical protein localization (GO:0045176)2.27961345
137positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.26673179
138RNA stabilization (GO:0043489)2.26063180
139mRNA stabilization (GO:0048255)2.26063180
140detection of temperature stimulus (GO:0016048)2.26052723
141transepithelial transport (GO:0070633)2.25652888
142phosphatidylinositol dephosphorylation (GO:0046856)2.25480777
143interleukin-6-mediated signaling pathway (GO:0070102)2.25217559
144early endosome to late endosome transport (GO:0045022)2.25016938
145cytidine catabolic process (GO:0006216)2.24774463
146microtubule nucleation (GO:0007020)2.22946830
147myoblast fusion (GO:0007520)2.20550797
148regulation of establishment of cell polarity (GO:2000114)2.20194498
149regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19732049
150cellular response to epinephrine stimulus (GO:0071872)2.19690279
151positive regulation of gamma-delta T cell activation (GO:0046645)2.19385785
152regulation of Rac protein signal transduction (GO:0035020)2.18959333
153phospholipid dephosphorylation (GO:0046839)2.16306602
154cellular response to growth hormone stimulus (GO:0071378)2.14750078
155peptidyl-serine phosphorylation (GO:0018105)2.14701580
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.14145592
157regulation of ARF GTPase activity (GO:0032312)2.13573894
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.11926226
159hypotonic response (GO:0006971)2.11354544
160positive regulation of granulocyte differentiation (GO:0030854)2.11194377
161mannose metabolic process (GO:0006013)2.10374606
162embryonic process involved in female pregnancy (GO:0060136)2.08422663
163phosphatidylinositol phosphorylation (GO:0046854)2.07186627
164histone H3-K9 modification (GO:0061647)2.06647568
165peptidyl-lysine methylation (GO:0018022)2.06339128
166nucleus organization (GO:0006997)2.05695973
167mitotic sister chromatid cohesion (GO:0007064)2.05449371
168syncytium formation by plasma membrane fusion (GO:0000768)2.04771917
169embryonic retina morphogenesis in camera-type eye (GO:0060059)2.04123233
170oocyte development (GO:0048599)2.03743574
171negative regulation of fatty acid transport (GO:2000192)2.03124679
172regulation of gamma-delta T cell activation (GO:0046643)2.02299470
173COPII vesicle coating (GO:0048208)2.01915297
174nerve growth factor signaling pathway (GO:0038180)2.01335411
175response to epinephrine (GO:0071871)1.99900433
176peptidyl-serine modification (GO:0018209)1.99551215
177embryonic eye morphogenesis (GO:0048048)1.97614517
178positive regulation of Rab GTPase activity (GO:0032851)1.97095806
179regulation of Rab GTPase activity (GO:0032313)1.97095806
180negative regulation of cell killing (GO:0031342)1.96034595
181negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.96034595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.57007546
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.57007546
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.57007546
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.64667509
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28533460
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.17275555
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.03204771
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.94057042
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.57460723
10GBX2_23144817_ChIP-Seq_PC3_Human2.42188119
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.34578041
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.29585113
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.27603970
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21345704
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21296234
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15720480
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14335988
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.13789379
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.08717694
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.01201440
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97843478
22TBX3_20139965_ChIP-Seq_ESCs_Mouse1.96950903
23TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96347359
24TBX3_20139965_ChIP-Seq_MESCs_Mouse1.96329714
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93907425
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.87793339
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.86267172
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.84792771
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83630671
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.76326015
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76180130
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75803291
33REST_21632747_ChIP-Seq_MESCs_Mouse1.74618749
34RUNX_20019798_ChIP-Seq_JUKART_Human1.67874064
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65901971
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63340567
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60979765
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60795472
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59843673
40EZH2_22144423_ChIP-Seq_EOC_Human1.58988678
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58213754
42STAT3_23295773_ChIP-Seq_U87_Human1.56210892
43TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.55633704
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55327501
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54355258
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53079811
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50389473
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49830852
49AR_21572438_ChIP-Seq_LNCaP_Human1.49290333
50NANOG_16518401_ChIP-PET_MESCs_Mouse1.47652946
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47599964
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.45761425
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45594416
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43360528
55AHR_22903824_ChIP-Seq_MCF-7_Human1.42188719
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41643739
57AR_19668381_ChIP-Seq_PC3_Human1.41408555
58E2F1_17053090_ChIP-ChIP_MCF-7_Human1.38410735
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37596275
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.36531182
61SCL_19346495_ChIP-Seq_HPC-7_Human1.36435326
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36069526
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.35754795
64* FOXO3_23340844_ChIP-Seq_DLD1_Human1.35585499
65PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.34773958
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29784321
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29490183
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29477484
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.27792798
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27733140
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27484109
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27326970
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26791113
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25769985
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.22877075
76POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.22005096
77RNF2_27304074_Chip-Seq_NSC_Mouse1.21593074
78SMAD4_21799915_ChIP-Seq_A2780_Human1.21156653
79IRF1_19129219_ChIP-ChIP_H3396_Human1.20681432
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20574218
81* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20101454
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19796483
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18548744
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18299591
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17840594
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17022160
87TCF7_22412390_ChIP-Seq_EML_Mouse1.16314053
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14962875
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14414978
90ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13949055
91PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13834517
92KDM2B_26808549_Chip-Seq_K562_Human1.13119302
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12506541
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11775966
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11600323
96* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11539982
97TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.11247356
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10889806
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10502209
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10090907
101RXR_22108803_ChIP-Seq_LS180_Human1.09874110
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09753213
103GATA1_19941826_ChIP-Seq_K562_Human1.08856278
104GATA2_19941826_ChIP-Seq_K562_Human1.07208737
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06865692
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06767139
107MYC_22102868_ChIP-Seq_BL_Human1.06664806
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06585066
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.06584181
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04862412
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.04800150
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04000048
113TCF4_23295773_ChIP-Seq_U87_Human1.03650701
114VDR_24787735_ChIP-Seq_THP-1_Human1.03498519
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02724386
116MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02655916
117NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01620132
118TAF15_26573619_Chip-Seq_HEK293_Human1.01115374
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.00291646
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00250439
121TP63_23658742_ChIP-Seq_EP156T_Human0.97658371
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97464643
123KDM2B_26808549_Chip-Seq_REH_Human0.97222285
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96401176
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96401176
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.96114386
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.95785214
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95603696
129TP53_16413492_ChIP-PET_HCT116_Human0.95531941
130IRF8_22096565_ChIP-ChIP_GC-B_Human0.95463335
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95317296
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95317296
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.95069083
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.95031188
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94919284
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.94648102
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94502350
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94342912
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94022446
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93726425
141GATA1_22025678_ChIP-Seq_K562_Human0.93712341
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93431403
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92950422
144* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.92304134
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92221397
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92170584
147PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91664666
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91287366
149ISL1_27105846_Chip-Seq_CPCs_Mouse0.91027865
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89237467
151EGR1_19374776_ChIP-ChIP_THP-1_Human0.89083288
152ER_23166858_ChIP-Seq_MCF-7_Human0.88868502
153DROSHA_22980978_ChIP-Seq_HELA_Human0.88692495
154GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88523830
155SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87313044
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.87267845
157NANOG_21062744_ChIP-ChIP_HESCs_Human0.86767634
158HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85295717
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85152569
160E2F7_22180533_ChIP-Seq_HELA_Human0.84782844
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84203630
162GATA1_26923725_Chip-Seq_HPCs_Mouse0.83214865
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.82809292
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82731880
165SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82350858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.30118630
2MP0004264_abnormal_extraembryonic_tissu3.36638441
3MP0003122_maternal_imprinting3.20848469
4MP0003787_abnormal_imprinting3.10565272
5MP0003890_abnormal_embryonic-extraembry3.05883729
6MP0005394_taste/olfaction_phenotype2.90094964
7MP0005499_abnormal_olfactory_system2.90094964
8MP0005409_darkened_coat_color2.78638476
9MP0004858_abnormal_nervous_system2.67935973
10MP0003121_genomic_imprinting2.67693910
11MP0009046_muscle_twitch2.51551445
12MP0002653_abnormal_ependyma_morphology2.42452971
13MP0010234_abnormal_vibrissa_follicle2.32139596
14MP0000569_abnormal_digit_pigmentation2.28931213
15MP0002396_abnormal_hematopoietic_system2.24675523
16MP0003183_abnormal_peptide_metabolism2.20349145
17MP0004036_abnormal_muscle_relaxation2.20236970
18MP0004130_abnormal_muscle_cell2.11195785
19MP0003763_abnormal_thymus_physiology2.09955901
20MP0004859_abnormal_synaptic_plasticity2.08104881
21MP0008057_abnormal_DNA_replication2.03064329
22MP0002166_altered_tumor_susceptibility2.01048776
23MP0005076_abnormal_cell_differentiation2.00020742
24MP0003011_delayed_dark_adaptation1.96681337
25MP0008961_abnormal_basal_metabolism1.96502495
26MP0002332_abnormal_exercise_endurance1.96182350
27MP0006035_abnormal_mitochondrial_morpho1.95655692
28MP0003656_abnormal_erythrocyte_physiolo1.85250502
29MP0006292_abnormal_olfactory_placode1.84798318
30MP0005275_abnormal_skin_tensile1.84241774
31MP0004084_abnormal_cardiac_muscle1.84017548
32MP0003635_abnormal_synaptic_transmissio1.81266966
33MP0003690_abnormal_glial_cell1.80807218
34MP0003646_muscle_fatigue1.77519653
35MP0003091_abnormal_cell_migration1.70959347
36MP0002572_abnormal_emotion/affect_behav1.70729125
37MP0010678_abnormal_skin_adnexa1.68064896
38MP0001486_abnormal_startle_reflex1.67110746
39MP0002254_reproductive_system_inflammat1.67055578
40MP0004270_analgesia1.64725323
41MP0004885_abnormal_endolymph1.64620294
42MP0002064_seizures1.62619968
43MP0005075_abnormal_melanosome_morpholog1.62598522
44MP0003705_abnormal_hypodermis_morpholog1.57035786
45MP0000383_abnormal_hair_follicle1.55428703
46MP0004043_abnormal_pH_regulation1.51471548
47MP0002063_abnormal_learning/memory/cond1.51036222
48MP0000733_abnormal_muscle_development1.45188175
49MP0005257_abnormal_intraocular_pressure1.41630527
50MP0009703_decreased_birth_body1.38783390
51MP0008872_abnormal_physiological_respon1.37690796
52MP0001984_abnormal_olfaction1.35677698
53MP0004808_abnormal_hematopoietic_stem1.35246691
54MP0005380_embryogenesis_phenotype1.35072409
55MP0001672_abnormal_embryogenesis/_devel1.35072409
56MP0009745_abnormal_behavioral_response1.33398072
57MP0002006_tumorigenesis1.32634000
58MP0002088_abnormal_embryonic_growth/wei1.31099614
59MP0003984_embryonic_growth_retardation1.30992842
60MP0005451_abnormal_body_composition1.29907441
61MP0009115_abnormal_fat_cell1.29307470
62MP0009780_abnormal_chondrocyte_physiolo1.26885126
63MP0003123_paternal_imprinting1.23980658
64MP0003868_abnormal_feces_composition1.22840959
65MP0002971_abnormal_brown_adipose1.21882205
66MP0001958_emphysema1.20519002
67MP0001851_eye_inflammation1.17305491
68MP0002272_abnormal_nervous_system1.15060360
69MP0008877_abnormal_DNA_methylation1.14114622
70MP0002877_abnormal_melanocyte_morpholog1.13037078
71MP0006138_congestive_heart_failure1.12866937
72MP0001440_abnormal_grooming_behavior1.12530900
73MP0010352_gastrointestinal_tract_polyps1.12175457
74MP0005666_abnormal_adipose_tissue1.11262474
75MP0005551_abnormal_eye_electrophysiolog1.10815420
76MP0003828_pulmonary_edema1.09867878
77MP0004484_altered_response_of1.08328700
78MP0002127_abnormal_cardiovascular_syste1.08280882
79MP0010368_abnormal_lymphatic_system1.07510747
80MP0002734_abnormal_mechanical_nocicepti1.07420669
81MP0002909_abnormal_adrenal_gland1.07366698
82MP0002822_catalepsy1.04868685
83MP0000955_abnormal_spinal_cord1.04138402
84MP0002067_abnormal_sensory_capabilities1.02117706
85MP0004924_abnormal_behavior1.01820945
86MP0005386_behavior/neurological_phenoty1.01820945
87MP0004142_abnormal_muscle_tone1.01641609
88MP0009672_abnormal_birth_weight0.99686032
89MP0003453_abnormal_keratinocyte_physiol0.99169855
90MP0004185_abnormal_adipocyte_glucose0.98071240
91MP0003119_abnormal_digestive_system0.97200948
92MP0002108_abnormal_muscle_morphology0.96818725
93MP0002229_neurodegeneration0.96733955
94MP0002086_abnormal_extraembryonic_tissu0.95877932
95MP0002970_abnormal_white_adipose0.95853228
96MP0002084_abnormal_developmental_patter0.95339427
97MP0001177_atelectasis0.94465579
98MP0004197_abnormal_fetal_growth/weight/0.94429192
99MP0001348_abnormal_lacrimal_gland0.91054142
100MP0001270_distended_abdomen0.90981048
101MP0002269_muscular_atrophy0.90022253
102MP0003300_gastrointestinal_ulcer0.89206766
103MP0004233_abnormal_muscle_weight0.87834127
104MP0003935_abnormal_craniofacial_develop0.87597448
105MP0005266_abnormal_metabolism0.87213947
106MP0000759_abnormal_skeletal_muscle0.87000464
107MP0000428_abnormal_craniofacial_morphol0.86984573
108MP0005646_abnormal_pituitary_gland0.86882981
109MP0008569_lethality_at_weaning0.86668276
110MP0008770_decreased_survivor_rate0.86525642
111MP0003861_abnormal_nervous_system0.86489065
112MP0002184_abnormal_innervation0.85745984
113MP0003566_abnormal_cell_adhesion0.85579131
114MP0004087_abnormal_muscle_fiber0.85511732
115MP0001661_extended_life_span0.85472078
116MP0000703_abnormal_thymus_morphology0.85441493
117MP0010307_abnormal_tumor_latency0.84556942
118MP0002882_abnormal_neuron_morphology0.83991211
119MP0003632_abnormal_nervous_system0.83733961
120MP0003045_fibrosis0.83722155
121MP0002133_abnormal_respiratory_system0.83394238
122MP0005388_respiratory_system_phenotype0.83394238
123MP0003880_abnormal_central_pattern0.83359257
124MP0000350_abnormal_cell_proliferation0.83143639
125MP0001324_abnormal_eye_pigmentation0.82346760
126MP0000920_abnormal_myelination0.81755971
127MP0004085_abnormal_heartbeat0.81610715
128MP0003283_abnormal_digestive_organ0.81352262
129MP0004811_abnormal_neuron_physiology0.81051804
130MP0005375_adipose_tissue_phenotype0.80792962
131MP0003191_abnormal_cellular_cholesterol0.80734024
132MP0002152_abnormal_brain_morphology0.80543463
133MP0002114_abnormal_axial_skeleton0.80248586
134MP0010630_abnormal_cardiac_muscle0.80217869
135MP0004947_skin_inflammation0.80018024
136MP0000747_muscle_weakness0.79075345
137MP0001879_abnormal_lymphatic_vessel0.79057227
138MP0002085_abnormal_embryonic_tissue0.78675884
139MP0001501_abnormal_sleep_pattern0.78660613
140MP0003329_amyloid_beta_deposits0.78588253
141MP0000778_abnormal_nervous_system0.78569978
142MP0004134_abnormal_chest_morphology0.78356267
143MP0005310_abnormal_salivary_gland0.77863620
144MP0005623_abnormal_meninges_morphology0.77339649
145MP0005621_abnormal_cell_physiology0.75505975
146MP0002081_perinatal_lethality0.75369256
147MP0000003_abnormal_adipose_tissue0.74956152
148MP0002557_abnormal_social/conspecific_i0.74894029
149MP0003879_abnormal_hair_cell0.74796113
150MP0002233_abnormal_nose_morphology0.74475365
151MP0001784_abnormal_fluid_regulation0.73993195
152MP0005253_abnormal_eye_physiology0.73378840
153MP0002925_abnormal_cardiovascular_devel0.72979606
154MP0003631_nervous_system_phenotype0.72906635
155MP0003755_abnormal_palate_morphology0.72735910
156MP0000427_abnormal_hair_cycle0.72037801
157MP0008789_abnormal_olfactory_epithelium0.71280622
158MP0000749_muscle_degeneration0.70341115
159MP0002998_abnormal_bone_remodeling0.70059984
160MP0000678_abnormal_parathyroid_gland0.69772396
161MP0000751_myopathy0.69768920
162MP0000013_abnormal_adipose_tissue0.68801187
163MP0005423_abnormal_somatic_nervous0.68138035
164MP0003252_abnormal_bile_duct0.67990191
165MP0006072_abnormal_retinal_apoptosis0.67629790
166MP0002168_other_aberrant_phenotype0.67518608
167MP0003115_abnormal_respiratory_system0.67420948
168MP0002752_abnormal_somatic_nervous0.67239924
169MP0003633_abnormal_nervous_system0.65927470
170MP0004145_abnormal_muscle_electrophysio0.64993594
171MP0000371_diluted_coat_color0.62998089
172MP0004381_abnormal_hair_follicle0.62907267
173MP0005670_abnormal_white_adipose0.62234082
174MP0002138_abnormal_hepatobiliary_system0.62098425
175MP0002060_abnormal_skin_morphology0.61940584

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.13914086
2Abnormality of the lower motor neuron (HP:0002366)4.83912754
3Hyperventilation (HP:0002883)4.44959141
4Bilateral microphthalmos (HP:0007633)4.40541629
5Ependymoma (HP:0002888)4.04838758
6Hepatoblastoma (HP:0002884)3.93760593
7Epileptic encephalopathy (HP:0200134)3.93260915
8Abnormality of the astrocytes (HP:0100707)3.81682362
9Astrocytoma (HP:0009592)3.81682362
10Febrile seizures (HP:0002373)3.76561893
11Abnormality of the fingertips (HP:0001211)3.29772751
12Resting tremor (HP:0002322)3.28975827
13Neoplasm of striated muscle (HP:0009728)3.16725728
14Macroorchidism (HP:0000053)3.00475430
15Rib fusion (HP:0000902)3.00286983
16Hypoplasia of the fovea (HP:0007750)2.94910317
17Aplasia/Hypoplasia of the fovea (HP:0008060)2.94910317
18Abnormality of the corticospinal tract (HP:0002492)2.93512363
19Rhabdomyosarcoma (HP:0002859)2.90230181
20Subaortic stenosis (HP:0001682)2.90134374
21Abnormality of the left ventricular outflow tract (HP:0011103)2.90134374
22Glioma (HP:0009733)2.89638068
23Atonic seizures (HP:0010819)2.85056351
24Hyperinsulinemic hypoglycemia (HP:0000825)2.84916530
25Hypopigmentation of the fundus (HP:0007894)2.82228425
26Focal seizures (HP:0007359)2.81908919
27Horizontal nystagmus (HP:0000666)2.64841331
28Neoplasm of the heart (HP:0100544)2.63408767
29Spontaneous hematomas (HP:0007420)2.63296813
30Overgrowth (HP:0001548)2.62840525
31Truncal obesity (HP:0001956)2.62830457
32Abnormality of chromosome segregation (HP:0002916)2.61670582
33Generalized hypotonia (HP:0001290)2.61176718
34Narrow palate (HP:0000189)2.48336853
35Amyotrophic lateral sclerosis (HP:0007354)2.48149599
36Aplasia/Hypoplasia of the macula (HP:0008059)2.46530414
37Excessive salivation (HP:0003781)2.44553566
38Drooling (HP:0002307)2.44553566
39Bifid tongue (HP:0010297)2.38894114
40Aortic aneurysm (HP:0004942)2.38561557
41Intestinal fistula (HP:0100819)2.38124480
42Open mouth (HP:0000194)2.36214054
43Focal motor seizures (HP:0011153)2.36011120
44Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.35674982
45Tetraplegia (HP:0002445)2.32571947
46Dialeptic seizures (HP:0011146)2.32333499
47Hyperkalemia (HP:0002153)2.28346761
48Sandal gap (HP:0001852)2.26233142
49Amblyopia (HP:0000646)2.24814934
50Malignant neoplasm of the central nervous system (HP:0100836)2.24560626
51Aplasia/Hypoplasia affecting the retina (HP:0008061)2.23805869
52Obstructive sleep apnea (HP:0002870)2.22514563
53Abnormality of the fovea (HP:0000493)2.20328837
54Status epilepticus (HP:0002133)2.17400155
55Neonatal hypoglycemia (HP:0001998)2.16536742
56Hyporeflexia of lower limbs (HP:0002600)2.15945889
57Dysmetric saccades (HP:0000641)2.15073826
58Insidious onset (HP:0003587)2.14785534
59Termporal pattern (HP:0011008)2.14785534
60Heterotopia (HP:0002282)2.13705710
61Abnormality of the labia minora (HP:0012880)2.12687892
62Abnormality of the salivary glands (HP:0010286)2.12277229
63Vertebral arch anomaly (HP:0008438)2.10367667
64Acute myeloid leukemia (HP:0004808)2.10171964
65Spinal cord lesions (HP:0100561)2.08707445
66Syringomyelia (HP:0003396)2.08707445
67Broad face (HP:0000283)2.06865350
68Fair hair (HP:0002286)2.06299213
69Cubitus valgus (HP:0002967)2.05682570
70Volvulus (HP:0002580)2.04316553
71Impulsivity (HP:0100710)2.03701350
72Nervous tissue neoplasm (HP:0030060)2.03528942
73Neuroectodermal neoplasm (HP:0030061)2.03528942
74Neuroepithelial neoplasm (HP:0030063)2.03528942
75Thyroid carcinoma (HP:0002890)2.02753645
76Mitral valve prolapse (HP:0001634)2.01855603
77Sensory axonal neuropathy (HP:0003390)2.01834803
78Poikilocytosis (HP:0004447)2.01091912
79Absent frontal sinuses (HP:0002688)1.99153738
80Hamartoma of the eye (HP:0010568)1.98952165
81Hand muscle atrophy (HP:0009130)1.98791716
82Papilledema (HP:0001085)1.98536289
83Difficulty running (HP:0009046)1.98425912
84Pseudobulbar signs (HP:0002200)1.97880090
85Arterial tortuosity (HP:0005116)1.97824088
86Ragged-red muscle fibers (HP:0003200)1.97478970
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97294186
88Papillary thyroid carcinoma (HP:0002895)1.97183443
89Subacute progressive viral hepatitis (HP:0006572)1.95552786
90Rectovaginal fistula (HP:0000143)1.93977078
91Rectal fistula (HP:0100590)1.93977078
92Short humerus (HP:0005792)1.93727857
93Generalized hypopigmentation of hair (HP:0011358)1.92904080
94Protruding tongue (HP:0010808)1.91551039
95Absence seizures (HP:0002121)1.90963318
96Nephroblastoma (Wilms tumor) (HP:0002667)1.90944662
97Germ cell neoplasia (HP:0100728)1.90583285
98Upper motor neuron abnormality (HP:0002127)1.89829306
99Generalized tonic-clonic seizures (HP:0002069)1.89510071
100Menstrual irregularities (HP:0000858)1.87634841
101Blue irides (HP:0000635)1.87170761
102Abnormality of the ischium (HP:0003174)1.86988983
103Dyschromatopsia (HP:0007641)1.86496731
104Dysdiadochokinesis (HP:0002075)1.85959544
105Visceral angiomatosis (HP:0100761)1.85915928
106Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.84061700
107Skin tags (HP:0010609)1.83043768
108Mask-like facies (HP:0000298)1.82648690
109Postural instability (HP:0002172)1.82029919
110Scanning speech (HP:0002168)1.81188544
111Deeply set eye (HP:0000490)1.80272455
112Preauricular skin tag (HP:0000384)1.79520261
113Abnormality of the epiphyses of the hand (HP:0005924)1.77417412
114Gaze-evoked nystagmus (HP:0000640)1.77141356
115Limb hypertonia (HP:0002509)1.76881410
116Hemangiomatosis (HP:0007461)1.75980548
117Deep philtrum (HP:0002002)1.75792186
118Vascular tortuosity (HP:0004948)1.75545250
119Complete atrioventricular canal defect (HP:0001674)1.75498589
120Freckling (HP:0001480)1.74364740
121Relative macrocephaly (HP:0004482)1.74257816
122Visual hallucinations (HP:0002367)1.73918114
123Large earlobe (HP:0009748)1.72827537
124Hemiparesis (HP:0001269)1.72406937
125Embryonal renal neoplasm (HP:0011794)1.72368626
126Ankyloglossia (HP:0010296)1.72010509
127Tented upper lip vermilion (HP:0010804)1.71177531
128Bowel incontinence (HP:0002607)1.71075135
129Failure to thrive in infancy (HP:0001531)1.70207352
130Urinary bladder sphincter dysfunction (HP:0002839)1.69666297
131Flat acetabular roof (HP:0003180)1.69497279
132Cerebral aneurysm (HP:0004944)1.69348707
133Distal upper limb amyotrophy (HP:0007149)1.69320258
134Upper limb amyotrophy (HP:0009129)1.69320258
135Colitis (HP:0002583)1.69247938
136Impaired vibratory sensation (HP:0002495)1.68685008
137Multiple enchondromatosis (HP:0005701)1.68605622
138Action tremor (HP:0002345)1.68434193
139Exercise-induced myalgia (HP:0003738)1.67949423
140Impaired vibration sensation in the lower limbs (HP:0002166)1.67949201
141Skin nodule (HP:0200036)1.67441503
142Abnormality of ocular smooth pursuit (HP:0000617)1.67416005
143Cone-rod dystrophy (HP:0000548)1.66960089
144Mild short stature (HP:0003502)1.66930975
145Esophageal varix (HP:0002040)1.66921891
146Tongue fasciculations (HP:0001308)1.66820966
147Hamartoma (HP:0010566)1.66494225
148Genetic anticipation (HP:0003743)1.65554621
149Hypoplastic ischia (HP:0003175)1.65401370
150Testicular atrophy (HP:0000029)1.65321917
151Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.64308373
152Medulloblastoma (HP:0002885)1.64303774
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.64106642
154Osteolytic defects of the hand bones (HP:0009699)1.64106642
155Shawl scrotum (HP:0000049)1.64024228
156Aneurysm (HP:0002617)1.63862069
157Dislocated radial head (HP:0003083)1.63542287
158Vaginal fistula (HP:0004320)1.63540894
159Abnormal hair whorl (HP:0010721)1.63012381
160Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62687607
161Aplasia/hypoplasia of the humerus (HP:0006507)1.62679008
162Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62591231
163Spastic tetraparesis (HP:0001285)1.62123865
164Tapered finger (HP:0001182)1.61797897
165Abnormal biliary tract physiology (HP:0012439)1.61725702
166Bile duct proliferation (HP:0001408)1.61725702
167Broad palm (HP:0001169)1.61680614
168Persistence of primary teeth (HP:0006335)1.60268826
169Hypoplasia of the iris (HP:0007676)1.60201396
170Increased variability in muscle fiber diameter (HP:0003557)1.59540604
171Lip pit (HP:0100267)1.58681630
172Spondylolisthesis (HP:0003302)1.58370020
173Abnormality of the distal phalanx of the thumb (HP:0009617)1.57835838
174Atrioventricular canal defect (HP:0006695)1.57736351
175Cystic hygroma (HP:0000476)1.55594029
176Slow saccadic eye movements (HP:0000514)1.55208049
177Cranial hyperostosis (HP:0004437)1.54763253
178Thick eyebrow (HP:0000574)1.54248645
179Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.53754976
180Degeneration of the lateral corticospinal tracts (HP:0002314)1.53754976
181T lymphocytopenia (HP:0005403)1.53290540
182Lower limb muscle weakness (HP:0007340)1.52843571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.77725504
2GRK53.31263336
3AKT33.16604286
4GRK62.63037246
5LMTK22.46394236
6MAP3K42.36092641
7PRPF4B2.24361903
8MAP2K42.18081151
9WNK12.11320718
10TYRO32.07073106
11ERN11.84086036
12SGK21.80518438
13NTRK31.78751979
14CASK1.75414444
15SGK31.73375868
16NEK91.68612935
17MAPK71.67377403
18GRK11.60573540
19TRIB31.58832322
20MAP3K21.57354634
21MAP3K131.57015892
22TRPM71.53946038
23ADRBK21.52505853
24NLK1.49881947
25FGFR31.41477256
26MAP3K71.40813502
27MARK21.38877520
28PRKG21.35248275
29MAP2K31.33886483
30KSR21.29872936
31MAP3K91.29186941
32NEK61.28285435
33SGK2231.26254810
34SGK4941.26254810
35BRD41.26217249
36SCYL21.25722091
37MAP2K71.24380408
38CSF1R1.23541771
39CAMKK21.23161206
40TTK1.21764672
41OBSCN1.20684294
42CAMK41.20453515
43JAK11.19160536
44PIK3CG1.18653468
45ALK1.16305710
46NTRK21.15391603
47PRKD31.13713585
48CAMKK11.13395247
49NTRK11.09937970
50TTN1.08377915
51TAOK31.06969252
52CAMK1D1.03597712
53PDGFRB1.03300668
54CAMK1G0.98792373
55INSRR0.97865085
56PRKCH0.97860734
57MTOR0.97135646
58SIK10.95729983
59YES10.93158514
60CDK60.93113177
61ICK0.91465068
62ACVR1B0.89160843
63FGFR40.89153539
64RIPK40.87164009
65MAP3K140.85624228
66PDK40.83891062
67PDK30.83891062
68PIK3CA0.82129863
69STK30.81874940
70PAK60.81340729
71HIPK20.81104863
72STK380.80946030
73CHEK20.77188493
74GRK70.75811851
75PRKAA20.75793712
76PRKAA10.75579923
77ADRBK10.74370436
78FGFR20.73369409
79RIPK10.72948923
80JAK20.69724920
81CHEK10.69438457
82MATK0.68182437
83CAMK10.66841824
84CDK30.65854698
85JAK30.65777008
86SIK20.65466142
87MAPK110.65011585
88TYK20.64982617
89MAP3K10.64284317
90AKT20.64179642
91MOS0.64090643
92DAPK20.63973891
93PTK2B0.63910432
94EPHA30.61644957
95MAPK100.61406381
96MAP3K100.61101321
97LATS10.60685175
98EPHA40.60544978
99MINK10.60056192
100PLK20.59234054
101STK100.58120016
102TSSK60.57625666
103MELK0.57413700
104TNK20.57093642
105STK110.56820047
106PRKCG0.55940469
107BTK0.55375556
108TGFBR20.55026360
109CSNK1E0.54805403
110HCK0.54337927
111RPS6KA30.53724802
112MET0.53679013
113PDPK10.53278509
114ZAP700.51553603
115DMPK0.51252742
116RPS6KB10.51179647
117RET0.50479697
118FRK0.50475514
119RAF10.50339929
120IRAK20.49908280
121RPS6KB20.49772802
122IRAK10.49597874
123DYRK1A0.48826441
124GSK3B0.48252898
125KSR10.46958292
126BLK0.46220268
127CDK20.45276911
128EEF2K0.45274469
129MARK10.44459100
130PDGFRA0.44267080
131ITK0.43827807
132IKBKE0.43483065
133DYRK1B0.43228728
134ATM0.42984627
135PDK10.42921649
136MAP3K60.42588722
137MAP4K10.42320343
138PNCK0.41682364
139MAPK140.41671150
140CSNK1D0.41132288
141SGK10.40398317
142TAOK20.40321925
143CDK50.40200097
144CDK40.39148234
145PKN20.38897276
146CDK10.38627859
147FGFR10.38463458
148CDK80.37416353
149PRKACB0.37251421
150MAPK80.36906212
151CDC42BPA0.36895352
152SIK30.35435681
153PAK30.34540963
154MAPK120.33082542

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.00607834
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.85182359
3Synaptic vesicle cycle_Homo sapiens_hsa047212.21518319
4Fructose and mannose metabolism_Homo sapiens_hsa000512.13037691
5Nicotine addiction_Homo sapiens_hsa050332.04362232
6mTOR signaling pathway_Homo sapiens_hsa041501.84762459
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.83041366
8GABAergic synapse_Homo sapiens_hsa047271.82888208
9Long-term potentiation_Homo sapiens_hsa047201.73975320
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.68909449
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65135974
12Olfactory transduction_Homo sapiens_hsa047401.60244241
13Taste transduction_Homo sapiens_hsa047421.57186482
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52961317
15Chronic myeloid leukemia_Homo sapiens_hsa052201.50504866
16B cell receptor signaling pathway_Homo sapiens_hsa046621.36895906
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34790589
18Acute myeloid leukemia_Homo sapiens_hsa052211.34679222
19Glutamatergic synapse_Homo sapiens_hsa047241.34250179
20Lysine degradation_Homo sapiens_hsa003101.31636260
21Morphine addiction_Homo sapiens_hsa050321.31164654
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30643336
23Renal cell carcinoma_Homo sapiens_hsa052111.29496795
24Pancreatic cancer_Homo sapiens_hsa052121.29390484
25Inositol phosphate metabolism_Homo sapiens_hsa005621.28593588
26Galactose metabolism_Homo sapiens_hsa000521.27728456
27Circadian entrainment_Homo sapiens_hsa047131.26046780
28Circadian rhythm_Homo sapiens_hsa047101.25138855
29Insulin secretion_Homo sapiens_hsa049111.24809047
30Dopaminergic synapse_Homo sapiens_hsa047281.20742332
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20566986
32Prolactin signaling pathway_Homo sapiens_hsa049171.20170610
33Long-term depression_Homo sapiens_hsa047301.19929018
34Salivary secretion_Homo sapiens_hsa049701.19351388
35Type II diabetes mellitus_Homo sapiens_hsa049301.16603619
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15725172
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15432371
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14672047
39FoxO signaling pathway_Homo sapiens_hsa040681.14416546
40VEGF signaling pathway_Homo sapiens_hsa043701.13863773
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.13755277
42Prostate cancer_Homo sapiens_hsa052151.12882992
43Renin secretion_Homo sapiens_hsa049241.11875752
44T cell receptor signaling pathway_Homo sapiens_hsa046601.10581720
45Platelet activation_Homo sapiens_hsa046111.08104310
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07626588
47Amphetamine addiction_Homo sapiens_hsa050311.05572730
48ErbB signaling pathway_Homo sapiens_hsa040121.05093777
49Nitrogen metabolism_Homo sapiens_hsa009101.04665682
50Bile secretion_Homo sapiens_hsa049761.04209310
51Calcium signaling pathway_Homo sapiens_hsa040201.02530962
52Adherens junction_Homo sapiens_hsa045201.01698963
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01556682
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00881708
55AMPK signaling pathway_Homo sapiens_hsa041520.99783260
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99691354
57Serotonergic synapse_Homo sapiens_hsa047260.97383031
58Glucagon signaling pathway_Homo sapiens_hsa049220.96505087
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95377491
60ABC transporters_Homo sapiens_hsa020100.94869714
61Endometrial cancer_Homo sapiens_hsa052130.94674973
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.94592084
63Non-small cell lung cancer_Homo sapiens_hsa052230.93839145
64mRNA surveillance pathway_Homo sapiens_hsa030150.93647886
65Focal adhesion_Homo sapiens_hsa045100.93053461
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92391649
67MicroRNAs in cancer_Homo sapiens_hsa052060.92030964
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90188726
69Arginine biosynthesis_Homo sapiens_hsa002200.89936992
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89810929
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89719258
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89357086
73Choline metabolism in cancer_Homo sapiens_hsa052310.89008987
74Dorso-ventral axis formation_Homo sapiens_hsa043200.88952088
75cAMP signaling pathway_Homo sapiens_hsa040240.88653372
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.88211003
77Pancreatic secretion_Homo sapiens_hsa049720.87879646
78Fatty acid biosynthesis_Homo sapiens_hsa000610.87758884
79Small cell lung cancer_Homo sapiens_hsa052220.86407262
80Osteoclast differentiation_Homo sapiens_hsa043800.86135288
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84790326
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82896305
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82100215
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81986166
85Oxytocin signaling pathway_Homo sapiens_hsa049210.78631979
86Selenocompound metabolism_Homo sapiens_hsa004500.78567881
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.77164557
88Collecting duct acid secretion_Homo sapiens_hsa049660.76863111
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.76091368
90GnRH signaling pathway_Homo sapiens_hsa049120.75929386
91Measles_Homo sapiens_hsa051620.75636722
92Butanoate metabolism_Homo sapiens_hsa006500.75400726
93Proteoglycans in cancer_Homo sapiens_hsa052050.75080974
94Glioma_Homo sapiens_hsa052140.74934464
95Insulin resistance_Homo sapiens_hsa049310.73062589
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.73044700
97Hepatitis B_Homo sapiens_hsa051610.72991905
98Insulin signaling pathway_Homo sapiens_hsa049100.72676819
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72067399
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71721556
101Hepatitis C_Homo sapiens_hsa051600.71494199
102Amoebiasis_Homo sapiens_hsa051460.71336880
103Notch signaling pathway_Homo sapiens_hsa043300.69530812
104Colorectal cancer_Homo sapiens_hsa052100.69294316
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.67430791
106Carbon metabolism_Homo sapiens_hsa012000.66604703
107Biosynthesis of amino acids_Homo sapiens_hsa012300.64269324
108Thyroid cancer_Homo sapiens_hsa052160.64024824
109Cholinergic synapse_Homo sapiens_hsa047250.63496823
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61193395
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61172073
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61134426
113Pyruvate metabolism_Homo sapiens_hsa006200.60555578
114Glycerolipid metabolism_Homo sapiens_hsa005610.60526845
115Phototransduction_Homo sapiens_hsa047440.60431636
116Ras signaling pathway_Homo sapiens_hsa040140.60177610
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59586160
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58775988
119MAPK signaling pathway_Homo sapiens_hsa040100.58465252
120ECM-receptor interaction_Homo sapiens_hsa045120.58406716
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56933192
122Gastric acid secretion_Homo sapiens_hsa049710.56850266
123Chemokine signaling pathway_Homo sapiens_hsa040620.56804931
124Toxoplasmosis_Homo sapiens_hsa051450.56748265
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56449029
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55816347
127TNF signaling pathway_Homo sapiens_hsa046680.55815419
128Endocytosis_Homo sapiens_hsa041440.55603800
129Gap junction_Homo sapiens_hsa045400.55548282
130Tryptophan metabolism_Homo sapiens_hsa003800.54825667
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53494477
132Influenza A_Homo sapiens_hsa051640.53307184
133Melanoma_Homo sapiens_hsa052180.52376949
134Cocaine addiction_Homo sapiens_hsa050300.52318917
135Ovarian steroidogenesis_Homo sapiens_hsa049130.51440227
136Estrogen signaling pathway_Homo sapiens_hsa049150.51125442
137Rap1 signaling pathway_Homo sapiens_hsa040150.48858647
138Dilated cardiomyopathy_Homo sapiens_hsa054140.48814642
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.48238909
140Vibrio cholerae infection_Homo sapiens_hsa051100.46650822
141Wnt signaling pathway_Homo sapiens_hsa043100.46180320
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42504079
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.41826513
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.41804640

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