ATG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.64028879
2L-phenylalanine catabolic process (GO:0006559)5.64028879
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.40063289
4L-phenylalanine metabolic process (GO:0006558)5.40063289
5aromatic amino acid family catabolic process (GO:0009074)4.84241526
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.31252805
7cysteine metabolic process (GO:0006534)4.21829306
8bile acid biosynthetic process (GO:0006699)4.15974516
9peptidyl-glutamic acid carboxylation (GO:0017187)4.11407921
10protein carboxylation (GO:0018214)4.11407921
11proteasome assembly (GO:0043248)4.08343855
12tryptophan catabolic process (GO:0006569)4.04033047
13indole-containing compound catabolic process (GO:0042436)4.04033047
14indolalkylamine catabolic process (GO:0046218)4.04033047
15aldehyde catabolic process (GO:0046185)4.00989494
16alpha-linolenic acid metabolic process (GO:0036109)3.92770192
17glyoxylate metabolic process (GO:0046487)3.89724849
18tryptophan metabolic process (GO:0006568)3.86552400
19low-density lipoprotein particle remodeling (GO:0034374)3.78220648
20regulation of cholesterol esterification (GO:0010872)3.76440778
21response to peptidoglycan (GO:0032494)3.69856999
22kynurenine metabolic process (GO:0070189)3.63467022
23neutrophil activation involved in immune response (GO:0002283)3.62016879
24cofactor catabolic process (GO:0051187)3.60702569
25disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.60237135
26killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.60237135
27blood coagulation, intrinsic pathway (GO:0007597)3.58011202
28aromatic amino acid family metabolic process (GO:0009072)3.58004664
29immunoglobulin mediated immune response (GO:0016064)3.57176003
30bile acid metabolic process (GO:0008206)3.52744336
31complement activation, alternative pathway (GO:0006957)3.52640387
32sulfur amino acid catabolic process (GO:0000098)3.52430513
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47612739
34regulation of protein activation cascade (GO:2000257)3.47445105
35high-density lipoprotein particle remodeling (GO:0034375)3.46239659
36regulation of fibrinolysis (GO:0051917)3.42428187
37plasma lipoprotein particle remodeling (GO:0034369)3.41282395
38protein-lipid complex remodeling (GO:0034368)3.41282395
39macromolecular complex remodeling (GO:0034367)3.41282395
40urea metabolic process (GO:0019627)3.40168659
41urea cycle (GO:0000050)3.40168659
42negative regulation of fibrinolysis (GO:0051918)3.38156008
43positive regulation by symbiont of host defense response (GO:0052509)3.37579132
44modulation by symbiont of host defense response (GO:0052031)3.37579132
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37579132
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37579132
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.37579132
48modulation by symbiont of host immune response (GO:0052553)3.37579132
49serine family amino acid catabolic process (GO:0009071)3.36867604
50coenzyme catabolic process (GO:0009109)3.36645531
51regulation of triglyceride catabolic process (GO:0010896)3.35341934
52nitrogen cycle metabolic process (GO:0071941)3.33592756
53antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.32658881
54regulation of complement activation (GO:0030449)3.29287604
55tyrosine metabolic process (GO:0006570)3.26383824
56ethanol oxidation (GO:0006069)3.24440464
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.24365564
58serine family amino acid biosynthetic process (GO:0009070)3.23521617
59respiratory burst (GO:0045730)3.23025290
60B cell mediated immunity (GO:0019724)3.22784254
61positive regulation of mast cell degranulation (GO:0043306)3.21259816
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.21259816
63microglial cell activation (GO:0001774)3.20671627
64serine family amino acid metabolic process (GO:0009069)3.19418407
65opsonization (GO:0008228)3.18125997
66macrophage activation involved in immune response (GO:0002281)3.17437733
67detection of molecule of bacterial origin (GO:0032490)3.16998218
68glycine metabolic process (GO:0006544)3.14407763
69plasma lipoprotein particle clearance (GO:0034381)3.12603547
70negative regulation of interleukin-12 production (GO:0032695)3.12420187
71phospholipid efflux (GO:0033700)3.11907793
72imidazole-containing compound metabolic process (GO:0052803)3.11086074
73alpha-amino acid catabolic process (GO:1901606)3.08646882
74positive regulation of mast cell activation (GO:0033005)3.06506808
75fibrinolysis (GO:0042730)3.04283399
76amino-acid betaine metabolic process (GO:0006577)3.04002904
77cellular biogenic amine catabolic process (GO:0042402)3.01779685
78amine catabolic process (GO:0009310)3.01779685
79positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.00820249
80primary alcohol catabolic process (GO:0034310)3.00535720
81disruption of cells of other organism (GO:0044364)2.99762886
82killing of cells of other organism (GO:0031640)2.99762886
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99107733
84neutrophil mediated immunity (GO:0002446)2.98125240
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96517877
86homocysteine metabolic process (GO:0050667)2.96391014
87myeloid cell activation involved in immune response (GO:0002275)2.96041467
88ethanol metabolic process (GO:0006067)2.88632883
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87904235
90triglyceride homeostasis (GO:0070328)2.86564836
91acylglycerol homeostasis (GO:0055090)2.86564836
92protein activation cascade (GO:0072376)2.86063876
93indolalkylamine metabolic process (GO:0006586)2.85561047
94reverse cholesterol transport (GO:0043691)2.85539175
95positive regulation of gamma-delta T cell activation (GO:0046645)2.85359133
96neutrophil activation (GO:0042119)2.84428071
97bile acid and bile salt transport (GO:0015721)2.84366934
98L-serine metabolic process (GO:0006563)2.84240429
99interferon-gamma-mediated signaling pathway (GO:0060333)2.84110811
100cholesterol efflux (GO:0033344)2.83704226
101DNA deamination (GO:0045006)2.82923180
102S-adenosylmethionine metabolic process (GO:0046500)2.81212092
103positive regulation of cellular amine metabolic process (GO:0033240)2.80650534
104Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80384084
105regulation of B cell receptor signaling pathway (GO:0050855)2.80376083
106response to interferon-beta (GO:0035456)2.79600163
107positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79086569
108urate metabolic process (GO:0046415)2.78565657
109very long-chain fatty acid metabolic process (GO:0000038)2.78195194
110cellular amino acid catabolic process (GO:0009063)2.77988003
111mast cell activation (GO:0045576)2.77416580
112NAD biosynthetic process (GO:0009435)2.76726298
113pyridine nucleotide biosynthetic process (GO:0019363)2.75493088
114nicotinamide nucleotide biosynthetic process (GO:0019359)2.75493088
115signal peptide processing (GO:0006465)2.74960063
116antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.73870364
117cellular glucuronidation (GO:0052695)2.73257306
118cell wall macromolecule catabolic process (GO:0016998)2.72613235
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72096832
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70646710
121macrophage activation (GO:0042116)2.70530565
122positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.69433465
123complement activation (GO:0006956)2.69372107
124positive regulation of interferon-alpha production (GO:0032727)2.68794473
125cellular ketone body metabolic process (GO:0046950)2.68702966
126regulation of RIG-I signaling pathway (GO:0039535)2.68586591
127benzene-containing compound metabolic process (GO:0042537)2.68365053
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68225470
129negative regulation of ligase activity (GO:0051352)2.68225470
130very-low-density lipoprotein particle assembly (GO:0034379)2.68211979
131regulation of cholesterol metabolic process (GO:0090181)2.67842253
132acute-phase response (GO:0006953)2.67497002
133deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.67342760
134short-chain fatty acid metabolic process (GO:0046459)2.66679862
135response to nitrosative stress (GO:0051409)2.66277205
136ribosome assembly (GO:0042255)2.65250393
137purine deoxyribonucleotide catabolic process (GO:0009155)2.64989432
138granulocyte activation (GO:0036230)2.64856222
139complement activation, classical pathway (GO:0006958)2.64454992
140regulation of interferon-alpha production (GO:0032647)2.64445772
141purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.63276514
142negative regulation of growth of symbiont in host (GO:0044130)2.62197854
143negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.62197854
144modulation of growth of symbiont involved in interaction with host (GO:0044144)2.62197854
145regulation of growth of symbiont in host (GO:0044126)2.62197854
146negative regulation of sterol transport (GO:0032372)2.62081626
147negative regulation of cholesterol transport (GO:0032375)2.62081626
148positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62060995
149regulation of cellular amino acid metabolic process (GO:0006521)2.61803668
150plasma lipoprotein particle organization (GO:0071827)2.61480754
151glucuronate metabolic process (GO:0019585)2.61426202
152uronic acid metabolic process (GO:0006063)2.61426202
153DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61031683
154positive regulation of type 2 immune response (GO:0002830)2.60295246
155regulation of inflammatory response to antigenic stimulus (GO:0002861)2.60046287
156organic acid catabolic process (GO:0016054)2.59510264
157carboxylic acid catabolic process (GO:0046395)2.59510264
158regulation of interferon-beta biosynthetic process (GO:0045357)2.58924405
159ribosomal large subunit biogenesis (GO:0042273)2.58907111
160positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.58475575
161regulation of mast cell degranulation (GO:0043304)2.57293017
162detection of external biotic stimulus (GO:0098581)2.56769646
163regulation of mast cell activation (GO:0033003)2.55781856
164intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55226852
165signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55226852
166cellular response to interferon-beta (GO:0035458)2.54902301
167response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53532429
168response to host immune response (GO:0052572)2.53532429
169positive regulation of B cell differentiation (GO:0045579)2.53345308
170chaperone-mediated protein transport (GO:0072321)2.52879014
171anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52138060
172signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51909068
173signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51909068
174signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51909068
175regulation of hypersensitivity (GO:0002883)2.49499842
176detection of other organism (GO:0098543)2.47251882
177response to xenobiotic stimulus (GO:0009410)2.45297246
178positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.44609096
179deoxyribose phosphate catabolic process (GO:0046386)2.43874410
180negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42736940
181defense response to protozoan (GO:0042832)2.41943931
182termination of RNA polymerase III transcription (GO:0006386)2.41746898
183transcription elongation from RNA polymerase III promoter (GO:0006385)2.41746898
184positive regulation of ligase activity (GO:0051351)2.41726276
185signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41420282
186signal transduction involved in DNA damage checkpoint (GO:0072422)2.41420282
187positive regulation of interleukin-17 production (GO:0032740)2.38062767
188myeloid leukocyte mediated immunity (GO:0002444)2.37445919
189positive regulation of interferon-beta production (GO:0032728)2.36727086
190regulation of mast cell activation involved in immune response (GO:0033006)2.36433420
191regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.34882164
192signal transduction involved in cell cycle checkpoint (GO:0072395)2.34790253
193ATP synthesis coupled proton transport (GO:0015986)2.34252038
194energy coupled proton transport, down electrochemical gradient (GO:0015985)2.34252038
195leukocyte degranulation (GO:0043299)2.33973956
196regulation of alpha-beta T cell proliferation (GO:0046640)2.33190046
197cellular response to interferon-gamma (GO:0071346)2.33030922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.32423397
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.98156815
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.60145115
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.21737823
5* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.87198011
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.55444577
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.54819918
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38291075
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.18680040
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11321928
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.96949684
12E2F7_22180533_ChIP-Seq_HELA_Human2.84368771
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.67624017
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30150603
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24139453
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19663289
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.18973277
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18728525
19GATA1_22025678_ChIP-Seq_K562_Human2.16137495
20FOXP3_21729870_ChIP-Seq_TREG_Human2.12427123
21* IRF8_27001747_Chip-Seq_BMDM_Mouse2.08326551
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06888607
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05123912
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.00435090
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95364053
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92715700
27* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92210589
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87933992
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83010712
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80601345
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79609003
32TFEB_21752829_ChIP-Seq_HELA_Human1.78747114
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.77982810
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77753809
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77349734
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75746683
37* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74968495
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69332240
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67514692
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65958555
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65035465
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64701006
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59696647
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58471265
45SPI1_23547873_ChIP-Seq_NB4_Human1.58144480
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55609195
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55230203
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54670049
49GABP_19822575_ChIP-Seq_HepG2_Human1.51598161
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48417891
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46374642
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45359984
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42627719
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.39242680
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38380941
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35611271
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33672525
58TTF2_22483619_ChIP-Seq_HELA_Human1.33424858
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32668236
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.32478072
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29454339
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28729115
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28222391
64* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26149106
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22028629
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21714450
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21120124
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20124413
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19694718
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19459777
71VDR_23849224_ChIP-Seq_CD4+_Human1.19186969
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18642354
73HTT_18923047_ChIP-ChIP_STHdh_Human1.17108863
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16527566
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16480940
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16311336
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12987783
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11324126
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.11232377
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08608030
81SCL_19346495_ChIP-Seq_HPC-7_Human1.07224845
82GATA3_27048872_Chip-Seq_THYMUS_Human1.06920540
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06536140
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.06132881
85* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05951296
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05264009
87DCP1A_22483619_ChIP-Seq_HELA_Human1.05099241
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04452270
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.03409073
90CIITA_25753668_ChIP-Seq_RAJI_Human1.03077451
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01368050
92KDM5A_27292631_Chip-Seq_BREAST_Human1.01276216
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01161583
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99578339
95* EST1_17652178_ChIP-ChIP_JURKAT_Human0.99456729
96XRN2_22483619_ChIP-Seq_HELA_Human0.98933469
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98745449
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98568746
99MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98296589
100ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98270969
101FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98121690
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97399757
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96029789
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95532142
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95386423
106MYB_26560356_Chip-Seq_TH2_Human0.94483150
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.94329130
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93586792
109VDR_24763502_ChIP-Seq_THP-1_Human0.93565134
110E2F1_21310950_ChIP-Seq_MCF-7_Human0.93302247
111E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92889748
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.92647056
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92425011
114PU_27001747_Chip-Seq_BMDM_Mouse0.92393400
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92237772
116MYC_18555785_ChIP-Seq_MESCs_Mouse0.90266737
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90068012
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88686446
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88505857
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88442928
121CLOCK_20551151_ChIP-Seq_293T_Human0.87920624
122GATA3_26560356_Chip-Seq_TH2_Human0.87321398
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.86614813
124EGR1_19032775_ChIP-ChIP_M12_Human0.85748258
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85107504
126MYB_26560356_Chip-Seq_TH1_Human0.84242003
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83463532
128PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82007532
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81784938
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81721707
131ELK1_19687146_ChIP-ChIP_HELA_Human0.80693017
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79548983
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77711269
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77407815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.43928652
2MP0005360_urolithiasis4.72997823
3MP0005365_abnormal_bile_salt4.03791846
4MP0005085_abnormal_gallbladder_physiolo3.93689589
5MP0008875_abnormal_xenobiotic_pharmacok3.60744865
6MP0003806_abnormal_nucleotide_metabolis3.49473394
7MP0009840_abnormal_foam_cell3.06665045
8MP0003724_increased_susceptibility_to2.63951706
9MP0002138_abnormal_hepatobiliary_system2.58797868
10MP0003436_decreased_susceptibility_to2.46005757
11MP0003252_abnormal_bile_duct2.40330737
12MP0001835_abnormal_antigen_presentation2.30544867
13MP0003195_calcinosis2.27167292
14MP0010329_abnormal_lipoprotein_level2.20001506
15MP0005332_abnormal_amino_acid2.16389118
16MP0005083_abnormal_biliary_tract2.13159270
17MP0003186_abnormal_redox_activity2.08193033
18MP0003191_abnormal_cellular_cholesterol2.01780437
19MP0001666_abnormal_nutrient_absorption1.95848297
20MP0003656_abnormal_erythrocyte_physiolo1.93930397
21MP0009785_altered_susceptibility_to1.91550830
22MP0002419_abnormal_innate_immunity1.83574756
23MP0001853_heart_inflammation1.83209365
24MP0002148_abnormal_hypersensitivity_rea1.78773183
25MP0008058_abnormal_DNA_repair1.78093659
26MP0005025_abnormal_response_to1.75953623
27MP0009764_decreased_sensitivity_to1.71421758
28MP0005451_abnormal_body_composition1.71418912
29MP0000609_abnormal_liver_physiology1.69020356
30MP0005000_abnormal_immune_tolerance1.67300859
31MP0000685_abnormal_immune_system1.65576049
32MP0008469_abnormal_protein_level1.61878460
33MP0003303_peritoneal_inflammation1.61616020
34MP0006082_CNS_inflammation1.60454364
35MP0001764_abnormal_homeostasis1.56948673
36MP0000015_abnormal_ear_pigmentation1.56829328
37MP0005671_abnormal_response_to1.55523317
38MP0002118_abnormal_lipid_homeostasis1.54298523
39MP0005319_abnormal_enzyme/_coenzyme1.52657665
40MP0000569_abnormal_digit_pigmentation1.52082117
41MP0005464_abnormal_platelet_physiology1.50013685
42MP0005584_abnormal_enzyme/coenzyme_acti1.49056179
43MP0010094_abnormal_chromosome_stability1.45991586
44MP0003011_delayed_dark_adaptation1.45541302
45MP0005310_abnormal_salivary_gland1.44948605
46MP0009697_abnormal_copulation1.44144743
47MP0000604_amyloidosis1.43090331
48MP0004957_abnormal_blastocyst_morpholog1.38374613
49MP0004019_abnormal_vitamin_homeostasis1.37722103
50MP0005075_abnormal_melanosome_morpholog1.35815836
51MP0001533_abnormal_skeleton_physiology1.35382600
52MP0002723_abnormal_immune_serum1.34631998
53MP0005397_hematopoietic_system_phenotyp1.33701206
54MP0001545_abnormal_hematopoietic_system1.33701206
55MP0003868_abnormal_feces_composition1.30685614
56MP0001845_abnormal_inflammatory_respons1.29589537
57MP0005084_abnormal_gallbladder_morpholo1.29449113
58MP0002452_abnormal_antigen_presenting1.29165018
59MP0001800_abnormal_humoral_immune1.28759216
60MP0009379_abnormal_foot_pigmentation1.26416016
61MP0003172_abnormal_lysosome_physiology1.25175916
62MP0006035_abnormal_mitochondrial_morpho1.23236544
63MP0001790_abnormal_immune_system1.20934577
64MP0005387_immune_system_phenotype1.20934577
65MP0005410_abnormal_fertilization1.18860728
66MP0009763_increased_sensitivity_to1.17686177
67MP0004381_abnormal_hair_follicle1.17322776
68MP0005058_abnormal_lysosome_morphology1.16749786
69MP0003718_maternal_effect1.15864285
70MP0003075_altered_response_to1.12960338
71MP0005636_abnormal_mineral_homeostasis1.12851720
72MP0002420_abnormal_adaptive_immunity1.12837572
73MP0001819_abnormal_immune_cell1.12380056
74MP0003077_abnormal_cell_cycle1.11611363
75MP0009643_abnormal_urine_homeostasis1.10499707
76MP0003693_abnormal_embryo_hatching1.10355547
77MP0005174_abnormal_tail_pigmentation1.09143661
78MP0002166_altered_tumor_susceptibility1.07891096
79MP0002396_abnormal_hematopoietic_system1.05796405
80MP0000920_abnormal_myelination1.04673401
81MP0000703_abnormal_thymus_morphology1.04287647
82MP0003866_abnormal_defecation1.02593310
83MP0003690_abnormal_glial_cell1.01588402
84MP0008057_abnormal_DNA_replication1.00538241
85MP0003300_gastrointestinal_ulcer0.99574561
86MP0006036_abnormal_mitochondrial_physio0.98882057
87MP0000358_abnormal_cell_content/0.97032197
88MP0003786_premature_aging0.96950913
89MP0003448_altered_tumor_morphology0.95006299
90MP0009333_abnormal_splenocyte_physiolog0.93746176
91MP0000465_gastrointestinal_hemorrhage0.92436064
92MP0001727_abnormal_embryo_implantation0.91657475
93MP0003329_amyloid_beta_deposits0.91378142
94MP0002405_respiratory_system_inflammati0.90503500
95MP0004947_skin_inflammation0.88424477
96MP0002019_abnormal_tumor_incidence0.87728369
97MP0000598_abnormal_liver_morphology0.86818786
98MP0004808_abnormal_hematopoietic_stem0.86100774
99MP0008877_abnormal_DNA_methylation0.85828609
100MP0002254_reproductive_system_inflammat0.85680564
101MP0005220_abnormal_exocrine_pancreas0.85419886
102MP0000716_abnormal_immune_system0.85019702
103MP0000313_abnormal_cell_death0.83997729
104MP0005164_abnormal_response_to0.83654768
105MP0005166_decreased_susceptibility_to0.82905185
106MP0009642_abnormal_blood_homeostasis0.81886798
107MP0002933_joint_inflammation0.81046634
108MP0005408_hypopigmentation0.81014678
109MP0009765_abnormal_xenobiotic_induced0.80986435
110MP0000343_altered_response_to0.80343331
111MP0010155_abnormal_intestine_physiology0.79414121
112MP0002006_tumorigenesis0.79144962
113MP0003221_abnormal_cardiomyocyte_apopto0.78380255
114MP0001851_eye_inflammation0.77093157
115MP0003111_abnormal_nucleus_morphology0.76294399
116MP0000689_abnormal_spleen_morphology0.74818403
117MP0001542_abnormal_bone_strength0.74466289
118MP0005376_homeostasis/metabolism_phenot0.73155771
119MP0002095_abnormal_skin_pigmentation0.71299678
120MP0000858_altered_metastatic_potential0.70952726
121MP0008260_abnormal_autophagy0.70756783
122MP0003638_abnormal_response/metabolism_0.70505933
123MP0008007_abnormal_cellular_replicative0.70465445
124MP0005647_abnormal_sex_gland0.69956666
125MP0004782_abnormal_surfactant_physiolog0.69942592
126MP0002398_abnormal_bone_marrow0.69494064
127MP0000490_abnormal_crypts_of0.68685570
128MP0001661_extended_life_span0.68552707
129MP0004147_increased_porphyrin_level0.68275901
130MP0002429_abnormal_blood_cell0.68167457
131MP0003183_abnormal_peptide_metabolism0.66085317
132MP0005266_abnormal_metabolism0.65650014
133MP0003646_muscle_fatigue0.65572383
134MP0001929_abnormal_gametogenesis0.65220638
135MP0003828_pulmonary_edema0.65127980
136MP0002132_abnormal_respiratory_system0.64529787
137MP0003763_abnormal_thymus_physiology0.63755459
138MP0005535_abnormal_body_temperature0.63248252
139MP0002136_abnormal_kidney_physiology0.63060333
140MP0008873_increased_physiological_sensi0.62734858
141MP0002722_abnormal_immune_system0.61922920

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.95348995
2Prolonged partial thromboplastin time (HP:0003645)5.00474488
3Intrahepatic cholestasis (HP:0001406)4.37879839
4Xanthomatosis (HP:0000991)4.27120230
5Recurrent gram-negative bacterial infections (HP:0005420)4.14242375
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.12969440
7Hyperlipoproteinemia (HP:0010980)4.10653990
8Hypobetalipoproteinemia (HP:0003563)4.10383176
9Deep venous thrombosis (HP:0002625)4.09401861
10Recurrent bacterial skin infections (HP:0005406)3.69342113
11Chronic mucocutaneous candidiasis (HP:0002728)3.65144539
12Recurrent cutaneous fungal infections (HP:0011370)3.65144539
13Chronic obstructive pulmonary disease (HP:0006510)3.62363715
14Obstructive lung disease (HP:0006536)3.62363715
15Joint hemorrhage (HP:0005261)3.58143220
16Recurrent abscess formation (HP:0002722)3.40523025
17Eczematoid dermatitis (HP:0000976)3.31739195
18Abnormality of the common coagulation pathway (HP:0010990)3.27534273
19Complement deficiency (HP:0004431)3.20151479
20Myositis (HP:0100614)3.17305470
21Fat malabsorption (HP:0002630)3.14412598
22Recurrent fungal infections (HP:0002841)3.11297159
23Acute necrotizing encephalopathy (HP:0006965)3.05304706
24Reduced antithrombin III activity (HP:0001976)3.01372921
25Retrobulbar optic neuritis (HP:0100654)3.00742355
26Optic neuritis (HP:0100653)3.00742355
27Hyperammonemia (HP:0001987)3.00252953
28Hyperglycinemia (HP:0002154)2.95197100
29Aplastic anemia (HP:0001915)2.92595490
30Abnormal mitochondria in muscle tissue (HP:0008316)2.90667013
31Orchitis (HP:0100796)2.87277603
32Steatorrhea (HP:0002570)2.86573756
33Abnormality of methionine metabolism (HP:0010901)2.86005234
34Hypoglycemic coma (HP:0001325)2.82184250
35Vacuolated lymphocytes (HP:0001922)2.82083094
36Abnormality of serine family amino acid metabolism (HP:0010894)2.79571182
37Abnormality of glycine metabolism (HP:0010895)2.79571182
38Abnormality of macrophages (HP:0004311)2.78440436
39Hemoptysis (HP:0002105)2.76967730
40Mitochondrial inheritance (HP:0001427)2.75400296
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74511614
42Increased CSF lactate (HP:0002490)2.74113811
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.74006824
44Systemic lupus erythematosus (HP:0002725)2.70790422
45Hypolipoproteinemia (HP:0010981)2.70409067
46Ketosis (HP:0001946)2.68785552
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66532617
48Type I transferrin isoform profile (HP:0003642)2.66382885
49Hyperglycinuria (HP:0003108)2.63266869
50Meningitis (HP:0001287)2.62982730
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62844037
52Anorexia (HP:0002039)2.61759853
53Abnormality of the intrinsic pathway (HP:0010989)2.60562244
54Abnormality of complement system (HP:0005339)2.60468565
55Recurrent skin infections (HP:0001581)2.60306280
56Epidermoid cyst (HP:0200040)2.56855379
57Encephalitis (HP:0002383)2.55960979
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.55648377
59Abnormality of fatty-acid metabolism (HP:0004359)2.55183029
60Progressive macrocephaly (HP:0004481)2.55169233
61Abnormality of serum amino acid levels (HP:0003112)2.49251290
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.48864718
63Glomerulonephritis (HP:0000099)2.48709246
64Vasculitis (HP:0002633)2.48442285
65Myocardial infarction (HP:0001658)2.46648678
66Agnosia (HP:0010524)2.45829674
67Generalized aminoaciduria (HP:0002909)2.43828928
68Hyperbilirubinemia (HP:0002904)2.43200619
69Gastrointestinal infarctions (HP:0005244)2.41306827
70Abnormality of glycolipid metabolism (HP:0010969)2.40696011
71Abnormality of liposaccharide metabolism (HP:0010968)2.40696011
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.40696011
73Cerebral edema (HP:0002181)2.40167242
74Axonal loss (HP:0003447)2.37838775
75Keratoconjunctivitis (HP:0001096)2.37364332
76Conjugated hyperbilirubinemia (HP:0002908)2.37227535
77Abnormality of the prostate (HP:0008775)2.36967534
78Purpura (HP:0000979)2.36136762
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35260674
80Dicarboxylic aciduria (HP:0003215)2.35260674
81Polyneuropathy (HP:0001271)2.35195709
82Recurrent viral infections (HP:0004429)2.35114899
83Mediastinal lymphadenopathy (HP:0100721)2.33940279
84Gangrene (HP:0100758)2.31209954
85Increased serum ferritin (HP:0003281)2.28186087
86Hepatic necrosis (HP:0002605)2.28098213
87Amyloidosis (HP:0011034)2.27865903
88Abnormality of iron homeostasis (HP:0011031)2.27488257
89Upper motor neuron abnormality (HP:0002127)2.26912395
90Skin rash (HP:0000988)2.26857065
91Panhypogammaglobulinemia (HP:0003139)2.26359226
92Microvesicular hepatic steatosis (HP:0001414)2.25446342
93Exertional dyspnea (HP:0002875)2.24538419
94Elevated erythrocyte sedimentation rate (HP:0003565)2.23093749
95Pulmonary infiltrates (HP:0002113)2.22273404
96Lethargy (HP:0001254)2.22264248
97Gingival bleeding (HP:0000225)2.21891031
98Increased IgM level (HP:0003496)2.20780549
99Delayed CNS myelination (HP:0002188)2.19209872
100T lymphocytopenia (HP:0005403)2.18140811
101Hypercholesterolemia (HP:0003124)2.17653955
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15995330
103Abnormal protein N-linked glycosylation (HP:0012347)2.15995330
104Abnormal protein glycosylation (HP:0012346)2.15995330
105Abnormal glycosylation (HP:0012345)2.15995330
106Keratoconjunctivitis sicca (HP:0001097)2.15661190
107Chronic otitis media (HP:0000389)2.15380555
108IgG deficiency (HP:0004315)2.15032874
109Multiple enchondromatosis (HP:0005701)2.14897778
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11452816
111Abnormality of transition element cation homeostasis (HP:0011030)2.10419578
112Granulocytopenia (HP:0001913)2.08218139
113Abnormality of cells of the erythroid lineage (HP:0012130)2.07977748
114Menorrhagia (HP:0000132)2.07099221
115Abnormality of T cells (HP:0002843)2.06967892
116Abnormality of pyrimidine metabolism (HP:0004353)2.06894534
117Epistaxis (HP:0000421)2.05890230
118Acanthocytosis (HP:0001927)2.05536767
119Fatigue (HP:0012378)2.05535006
120Spastic paraparesis (HP:0002313)2.03667539
121Increased intramyocellular lipid droplets (HP:0012240)2.01430416
122Leukocytosis (HP:0001974)2.01351408
123Abnormal spermatogenesis (HP:0008669)2.00510459
124Hypoalphalipoproteinemia (HP:0003233)2.00237899
125Chest pain (HP:0100749)1.99989509
126Oral leukoplakia (HP:0002745)1.99694327
127Renal Fanconi syndrome (HP:0001994)1.98858749
128Abnormality of T cell number (HP:0011839)1.98063198
129Increased muscle lipid content (HP:0009058)1.98005829
130Amaurosis fugax (HP:0100576)1.97942927
131Cerebral hemorrhage (HP:0001342)1.97653658
132Basal ganglia calcification (HP:0002135)1.97344358
133Abnormality of nucleobase metabolism (HP:0010932)1.97288846
134Lactic acidosis (HP:0003128)1.97152158
135Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96949290
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96949290
137Hepatocellular necrosis (HP:0001404)1.96748347
138Increased serum lactate (HP:0002151)1.96441771
139Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95972047
140Abnormality of T cell physiology (HP:0011840)1.95662688
141Ketoacidosis (HP:0001993)1.94802647
142Hepatosplenomegaly (HP:0001433)1.94087865
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.93993229
144Glomerulopathy (HP:0100820)1.93265788
145Irritability (HP:0000737)1.93141343
146Metabolic acidosis (HP:0001942)1.93026071
147Abnormality of purine metabolism (HP:0004352)1.92486002
1483-Methylglutaconic aciduria (HP:0003535)1.92352019
149Pancreatitis (HP:0001733)1.92027659
150Disinhibition (HP:0000734)1.91766846
151Stomatitis (HP:0010280)1.91423168
152Glycosuria (HP:0003076)1.90948980
153Abnormality of urine glucose concentration (HP:0011016)1.90948980
154Eosinophilia (HP:0001880)1.90730567
155Lipid accumulation in hepatocytes (HP:0006561)1.90536544
156Urticaria (HP:0001025)1.90374292
157Abnormality of the pleura (HP:0002103)1.90171164
158Acute encephalopathy (HP:0006846)1.88876627
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.88207018
160Nausea (HP:0002018)1.88105052
161Vascular calcification (HP:0004934)1.87729414
162Tinnitus (HP:0000360)1.85478161
163Pulmonary fibrosis (HP:0002206)1.85374347
164Acute hepatic failure (HP:0006554)1.85138543
165Opisthotonus (HP:0002179)1.84403978
166Brushfield spots (HP:0001088)1.84307360
167Pulmonary embolism (HP:0002204)1.84005542
168Increased hepatocellular lipid droplets (HP:0006565)1.82151034
169Paraparesis (HP:0002385)1.81438717
170Degeneration of anterior horn cells (HP:0002398)1.81417212
171Abnormality of the anterior horn cell (HP:0006802)1.81417212
172Spontaneous abortion (HP:0005268)1.80491989
173Petechiae (HP:0000967)1.80204340
174Microcytic anemia (HP:0001935)1.80011170
175Neurofibrillary tangles (HP:0002185)1.79771047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.45687256
2BCKDK2.80263265
3PIM22.79038867
4EIF2AK32.61519359
5BLK2.59383964
6EIF2AK12.41360827
7IRAK42.37883775
8RIPK42.37651440
9TYK22.30435651
10STK162.17551607
11TEC2.16803050
12PBK2.16493655
13TBK12.16102329
14ERN12.08179579
15ACVR1B2.07690475
16TAOK32.04043383
17IRAK31.89975386
18KDR1.83552837
19ABL21.83263928
20NEK11.82780587
21TESK21.81918070
22KIT1.79813267
23ARAF1.78432022
24MAP3K141.76325201
25MAP4K11.58668234
26BTK1.57841559
27VRK21.46051373
28NLK1.45045984
29PIK3CG1.41225405
30BUB11.39418754
31IKBKE1.35198972
32SRPK11.33752542
33NEK91.33253209
34FLT31.31399584
35RPS6KA41.30447362
36LRRK21.25163810
37TNIK1.23130172
38IRAK11.22153761
39FGFR41.21273805
40JAK31.20494024
41FES1.19741366
42PLK41.19224366
43IKBKB1.16404375
44PDK21.14735157
45IRAK21.14171339
46ZAP701.07462545
47TRIM281.07123655
48LYN1.05939590
49CSF1R1.03360300
50BMPR1B1.03225999
51MAPKAPK51.02287810
52MST40.98964034
53SCYL20.97965365
54SYK0.97656824
55ITK0.97206944
56MAPK150.96758109
57DYRK30.96458096
58FGR0.95832034
59MAP4K20.95480237
60EPHB10.93923924
61MAP3K10.89537393
62MATK0.88539562
63PAK40.87940954
64CSK0.87643228
65MARK30.86726984
66MST1R0.86257251
67MAPK40.84630976
68SIK10.83014356
69JAK20.82266694
70GRK60.81869934
71PLK20.81322128
72PIM10.81072412
73JAK10.80495669
74VRK10.79697306
75PRKCQ0.79237834
76MAPK110.79059348
77PTK2B0.77993400
78DAPK10.76977580
79RAF10.76968937
80STK390.76262921
81ERBB40.74728346
82GRK70.72525037
83MYLK0.72408851
84LCK0.72115190
85MAP3K120.71964153
86TESK10.71943963
87CDK190.70293977
88BRAF0.68668646
89MAP3K110.66413979
90TAOK20.65872717
91BMPR20.65190695
92TXK0.65136049
93ILK0.64417797
94PAK10.63686206
95MUSK0.59618819
96ABL10.58920400
97WEE10.58859395
98CDC70.58284167
99MAP2K30.58141431
100MAP3K30.57433131
101AURKB0.54602039
102HCK0.52905045
103PLK10.52719884
104ADRBK20.52035158
105CDK80.51783458
106RPS6KA50.51394326
107PRKG20.49768831
108CDK70.49215105
109STK40.49201612
110TNK20.48804705
111DYRK20.48485679
112TRPM70.47871146
113EIF2AK20.47584117
114PRKCD0.46911204
115CSNK2A20.46809377
116STK100.46355116
117CSNK2A10.44454761
118EGFR0.44046291
119MOS0.42685071
120CAMKK20.41931711
121FGFR20.41634110
122DYRK1B0.40915264
123PLK30.40902732
124MAP3K50.40479361
125MAPKAPK30.40474673
126CSNK1G10.39451346
127NUAK10.39325007
128FRK0.38618239
129OXSR10.38434061
130INSRR0.36834599
131MAP3K80.35737225
132BRSK20.35725742
133CSNK1G30.35083464
134MAPK120.34815614
135MAP3K130.34608756
136TGFBR20.34119282
137SIK30.33158781

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.80350765
2Allograft rejection_Homo sapiens_hsa053303.36157060
3Autoimmune thyroid disease_Homo sapiens_hsa053203.04760140
4Type I diabetes mellitus_Homo sapiens_hsa049402.87679661
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71736557
6Caffeine metabolism_Homo sapiens_hsa002322.61573153
7Nitrogen metabolism_Homo sapiens_hsa009102.58505030
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48808843
9Folate biosynthesis_Homo sapiens_hsa007902.45382216
10Complement and coagulation cascades_Homo sapiens_hsa046102.40855357
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36368418
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35818320
13Antigen processing and presentation_Homo sapiens_hsa046122.30502431
14Staphylococcus aureus infection_Homo sapiens_hsa051502.23726870
15Peroxisome_Homo sapiens_hsa041462.15079138
16Histidine metabolism_Homo sapiens_hsa003402.14962367
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04371033
18Arginine biosynthesis_Homo sapiens_hsa002202.00790085
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96955914
20DNA replication_Homo sapiens_hsa030301.93945780
21Fatty acid degradation_Homo sapiens_hsa000711.92300611
22Tryptophan metabolism_Homo sapiens_hsa003801.91906249
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87671312
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86730726
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86034478
26Viral myocarditis_Homo sapiens_hsa054161.82918723
27Mismatch repair_Homo sapiens_hsa034301.81788188
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.81425053
29Chemical carcinogenesis_Homo sapiens_hsa052041.80764904
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75804527
31Protein export_Homo sapiens_hsa030601.75458530
32Fatty acid elongation_Homo sapiens_hsa000621.69161051
33Steroid biosynthesis_Homo sapiens_hsa001001.67835436
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.66655156
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57475446
36Retinol metabolism_Homo sapiens_hsa008301.53431905
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51631678
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51382221
39beta-Alanine metabolism_Homo sapiens_hsa004101.50996347
40Sulfur metabolism_Homo sapiens_hsa009201.50947732
41Homologous recombination_Homo sapiens_hsa034401.49352998
42Vitamin B6 metabolism_Homo sapiens_hsa007501.46662997
43PPAR signaling pathway_Homo sapiens_hsa033201.45485968
44Ribosome_Homo sapiens_hsa030101.41943100
45Primary immunodeficiency_Homo sapiens_hsa053401.40372314
46Butanoate metabolism_Homo sapiens_hsa006501.39541671
47Herpes simplex infection_Homo sapiens_hsa051681.37915302
48Propanoate metabolism_Homo sapiens_hsa006401.37682113
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34436461
50Proteasome_Homo sapiens_hsa030501.34069510
51Nucleotide excision repair_Homo sapiens_hsa034201.28509074
52Pentose phosphate pathway_Homo sapiens_hsa000301.25987356
53Sulfur relay system_Homo sapiens_hsa041221.24562323
54Base excision repair_Homo sapiens_hsa034101.24433195
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23848363
56Fatty acid metabolism_Homo sapiens_hsa012121.22059775
57Influenza A_Homo sapiens_hsa051641.21928607
58Huntingtons disease_Homo sapiens_hsa050161.21490095
59Non-homologous end-joining_Homo sapiens_hsa034501.20549297
60Spliceosome_Homo sapiens_hsa030401.18041589
61RNA transport_Homo sapiens_hsa030131.11803056
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11753157
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.10582277
64Phenylalanine metabolism_Homo sapiens_hsa003601.10509709
65Epstein-Barr virus infection_Homo sapiens_hsa051691.09546173
66Selenocompound metabolism_Homo sapiens_hsa004501.08206783
67Basal transcription factors_Homo sapiens_hsa030221.05860226
68Tyrosine metabolism_Homo sapiens_hsa003501.04085321
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03588205
70Glutathione metabolism_Homo sapiens_hsa004801.01219181
71Toxoplasmosis_Homo sapiens_hsa051451.00689893
72* Regulation of autophagy_Homo sapiens_hsa041401.00511645
73Shigellosis_Homo sapiens_hsa051310.98019273
74Vitamin digestion and absorption_Homo sapiens_hsa049770.97034788
75Starch and sucrose metabolism_Homo sapiens_hsa005000.95654376
76Measles_Homo sapiens_hsa051620.94333444
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90798044
78Pyruvate metabolism_Homo sapiens_hsa006200.88932929
79Collecting duct acid secretion_Homo sapiens_hsa049660.87334978
80RNA degradation_Homo sapiens_hsa030180.86049056
81Arginine and proline metabolism_Homo sapiens_hsa003300.84718596
82Biosynthesis of amino acids_Homo sapiens_hsa012300.84624710
83Systemic lupus erythematosus_Homo sapiens_hsa053220.82935160
84Oxidative phosphorylation_Homo sapiens_hsa001900.82155830
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77552144
86Fat digestion and absorption_Homo sapiens_hsa049750.75211884
87African trypanosomiasis_Homo sapiens_hsa051430.74995659
88Carbon metabolism_Homo sapiens_hsa012000.74846940
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74620473
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.72661038
91Salmonella infection_Homo sapiens_hsa051320.72482017
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72035274
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.71531065
94Leishmaniasis_Homo sapiens_hsa051400.70842831
95ABC transporters_Homo sapiens_hsa020100.70583394
96Lysosome_Homo sapiens_hsa041420.69215997
97Fanconi anemia pathway_Homo sapiens_hsa034600.67707555
98Metabolic pathways_Homo sapiens_hsa011000.67565587
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65130254
100Bile secretion_Homo sapiens_hsa049760.61633912
101Pertussis_Homo sapiens_hsa051330.61172568
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58196326
103Pyrimidine metabolism_Homo sapiens_hsa002400.58165035
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57280628
105Phagosome_Homo sapiens_hsa041450.56847301
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.55910601
107RNA polymerase_Homo sapiens_hsa030200.54768396
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54740556
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54656298
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53898502
111Purine metabolism_Homo sapiens_hsa002300.52947392
112Parkinsons disease_Homo sapiens_hsa050120.52919993
113Malaria_Homo sapiens_hsa051440.52778970
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50784736
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.50449752
116Cell cycle_Homo sapiens_hsa041100.48414362
117Other glycan degradation_Homo sapiens_hsa005110.47545663
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47484899
119Glycerolipid metabolism_Homo sapiens_hsa005610.45056330
120Asthma_Homo sapiens_hsa053100.44538626
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44257117
122Legionellosis_Homo sapiens_hsa051340.44196155
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41107448
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40984172
125mRNA surveillance pathway_Homo sapiens_hsa030150.40333789
126Apoptosis_Homo sapiens_hsa042100.39299669
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39287348
128B cell receptor signaling pathway_Homo sapiens_hsa046620.39174241
129Tuberculosis_Homo sapiens_hsa051520.38683918
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38079882
131T cell receptor signaling pathway_Homo sapiens_hsa046600.37562816
132p53 signaling pathway_Homo sapiens_hsa041150.37028311
133Osteoclast differentiation_Homo sapiens_hsa043800.36245854
134Hepatitis B_Homo sapiens_hsa051610.35697135
135Sphingolipid metabolism_Homo sapiens_hsa006000.35443503
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35411519
137TNF signaling pathway_Homo sapiens_hsa046680.34630796
138Linoleic acid metabolism_Homo sapiens_hsa005910.34194858
139Chemokine signaling pathway_Homo sapiens_hsa040620.33719851
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32902664
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.32679463
142One carbon pool by folate_Homo sapiens_hsa006700.31716860
143HTLV-I infection_Homo sapiens_hsa051660.30969129
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29392128
145Alzheimers disease_Homo sapiens_hsa050100.29229716
146Graft-versus-host disease_Homo sapiens_hsa053320.28811518
147Arachidonic acid metabolism_Homo sapiens_hsa005900.28423127
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28319692
149Hematopoietic cell lineage_Homo sapiens_hsa046400.27871704
150Renin-angiotensin system_Homo sapiens_hsa046140.27706437
151Rheumatoid arthritis_Homo sapiens_hsa053230.26879453
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26404429
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24900746
154Viral carcinogenesis_Homo sapiens_hsa052030.23617666
155Glycosaminoglycan degradation_Homo sapiens_hsa005310.23452145
156N-Glycan biosynthesis_Homo sapiens_hsa005100.22717451
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22617504
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22523326

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