ATG4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.20906079
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.20906079
3antigen processing and presentation of endogenous antigen (GO:0019883)6.63874228
4proteasome assembly (GO:0043248)4.42477979
5antigen processing and presentation via MHC class Ib (GO:0002475)4.27677972
6positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)4.05996533
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.86080543
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78796243
9COPII vesicle coating (GO:0048208)3.78465146
10positive regulation of antigen processing and presentation (GO:0002579)3.71269319
11regulation of cellular amino acid metabolic process (GO:0006521)3.70517260
12ribosome assembly (GO:0042255)3.60696933
13NADH metabolic process (GO:0006734)3.57313726
14valine metabolic process (GO:0006573)3.53245279
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51030899
16respiratory burst (GO:0045730)3.49312854
17ER to Golgi vesicle-mediated transport (GO:0006888)3.36626234
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35027819
19activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.34741819
20protoporphyrinogen IX metabolic process (GO:0046501)3.33828800
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29163780
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26907735
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24822469
24porphyrin-containing compound biosynthetic process (GO:0006779)3.21867485
25regulation of antigen processing and presentation (GO:0002577)3.21150985
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17387082
27signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17387082
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17189066
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17189066
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17189066
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16645663
32porphyrin-containing compound metabolic process (GO:0006778)3.16401820
33positive regulation of natural killer cell differentiation (GO:0032825)3.10875904
34tetrapyrrole biosynthetic process (GO:0033014)3.10123124
35positive regulation of gamma-delta T cell activation (GO:0046645)3.09838059
36protoporphyrinogen IX biosynthetic process (GO:0006782)3.08800808
37COPI coating of Golgi vesicle (GO:0048205)3.07152184
38Golgi transport vesicle coating (GO:0048200)3.07152184
39protein deneddylation (GO:0000338)3.07118980
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04004619
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.04004619
42tricarboxylic acid cycle (GO:0006099)3.03707697
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00872859
44positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.99819704
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99761571
46negative regulation of ligase activity (GO:0051352)2.99761571
47neutrophil activation involved in immune response (GO:0002283)2.98833200
48cysteine metabolic process (GO:0006534)2.98091727
49cytokinetic process (GO:0032506)2.97722659
50piRNA metabolic process (GO:0034587)2.96088728
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95937316
52positive regulation of ligase activity (GO:0051351)2.95683294
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94654613
54signal transduction involved in cell cycle checkpoint (GO:0072395)2.93270581
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.89575456
56kynurenine metabolic process (GO:0070189)2.87650961
57negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.87571411
587-methylguanosine mRNA capping (GO:0006370)2.84948625
59protein maturation by protein folding (GO:0022417)2.84898215
60production of molecular mediator involved in inflammatory response (GO:0002532)2.84487352
61hydrogen peroxide biosynthetic process (GO:0050665)2.81967878
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.80237915
63positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.80004493
64tryptophan metabolic process (GO:0006568)2.79555312
65alpha-linolenic acid metabolic process (GO:0036109)2.78976532
66ribonucleoprotein complex disassembly (GO:0032988)2.78310333
67signal peptide processing (GO:0006465)2.77949909
68low-density lipoprotein particle clearance (GO:0034383)2.77695672
69oxaloacetate metabolic process (GO:0006107)2.77316016
70positive regulation of interferon-alpha production (GO:0032727)2.74830108
71aldehyde catabolic process (GO:0046185)2.74805999
72regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74772730
73antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.73815126
747-methylguanosine RNA capping (GO:0009452)2.73788523
75RNA capping (GO:0036260)2.73788523
76cellular response to zinc ion (GO:0071294)2.73683913
77tryptophan catabolic process (GO:0006569)2.69851938
78indole-containing compound catabolic process (GO:0042436)2.69851938
79indolalkylamine catabolic process (GO:0046218)2.69851938
80sulfur amino acid catabolic process (GO:0000098)2.69851548
81galactose catabolic process (GO:0019388)2.69695648
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69601482
83L-phenylalanine catabolic process (GO:0006559)2.69601482
84respiratory electron transport chain (GO:0022904)2.67618093
85aromatic amino acid family catabolic process (GO:0009074)2.67296309
86reactive oxygen species biosynthetic process (GO:1903409)2.67232238
87cullin deneddylation (GO:0010388)2.66247908
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65836650
89tetrapyrrole metabolic process (GO:0033013)2.62683532
90nucleobase-containing small molecule interconversion (GO:0015949)2.62364371
91electron transport chain (GO:0022900)2.61607000
92heart process (GO:0003015)2.60533538
93heart contraction (GO:0060047)2.60533538
94purine-containing compound salvage (GO:0043101)2.59390426
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58813720
96L-phenylalanine metabolic process (GO:0006558)2.58813720
97regulation of interferon-alpha production (GO:0032647)2.58376573
98complement activation, alternative pathway (GO:0006957)2.58300684
99regulation of cellular amine metabolic process (GO:0033238)2.55132768
100plasma lipoprotein particle clearance (GO:0034381)2.53552126
101muscle filament sliding (GO:0030049)2.53415554
102actin-myosin filament sliding (GO:0033275)2.53415554
103response to hydroperoxide (GO:0033194)2.53334775
104lysine catabolic process (GO:0006554)2.52950332
105lysine metabolic process (GO:0006553)2.52950332
106sequestering of metal ion (GO:0051238)2.51876433
107negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.51399677
108amino-acid betaine transport (GO:0015838)2.50860685
109carnitine transport (GO:0015879)2.50860685
110deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.49220666
111ubiquinone biosynthetic process (GO:0006744)2.48645038
112regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48627050
113urate metabolic process (GO:0046415)2.47765499
114regulation of acyl-CoA biosynthetic process (GO:0050812)2.46546548
115apoptotic DNA fragmentation (GO:0006309)2.45679808
116purine nucleotide salvage (GO:0032261)2.45653540
117regulation of ligase activity (GO:0051340)2.45584366
118membrane budding (GO:0006900)2.45221886
119fatty acid beta-oxidation (GO:0006635)2.44916024
120negative regulation of protein ubiquitination (GO:0031397)2.44451994
121carnitine transmembrane transport (GO:1902603)2.44081470
122regulation of metalloenzyme activity (GO:0048552)2.43883045
123glycosphingolipid catabolic process (GO:0046479)2.43100345
124peptidyl-histidine modification (GO:0018202)2.42692401
125regulation of ubiquitin-protein transferase activity (GO:0051438)2.42261216
126positive regulation of DNA-templated transcription, elongation (GO:0032786)2.41956526
127NADPH regeneration (GO:0006740)2.41712968
128vesicle coating (GO:0006901)2.41258478
129peroxisome fission (GO:0016559)2.41009169
130chaperone-mediated protein transport (GO:0072321)2.40792307
131pyrimidine ribonucleoside catabolic process (GO:0046133)2.40582924
132protein carboxylation (GO:0018214)2.40532794
133peptidyl-glutamic acid carboxylation (GO:0017187)2.40532794
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40375675
135cellular ketone body metabolic process (GO:0046950)2.40227517
136heme metabolic process (GO:0042168)2.39584694
137positive regulation of cell cycle arrest (GO:0071158)2.39331993
138positive regulation of Rho protein signal transduction (GO:0035025)2.37270695
139hemoglobin metabolic process (GO:0020027)2.37064306
140heme biosynthetic process (GO:0006783)2.37061111
141regulation of interferon-beta biosynthetic process (GO:0045357)2.36457254
142leukocyte aggregation (GO:0070486)2.36166217
143glycolipid catabolic process (GO:0019377)2.36098872
144quinone biosynthetic process (GO:1901663)2.35988961
145necroptotic process (GO:0070266)2.35118631
146ribosomal large subunit biogenesis (GO:0042273)2.35000934
147regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.34967335
148positive regulation of receptor internalization (GO:0002092)2.34728381
149negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.34627508
150pentose-phosphate shunt (GO:0006098)2.33465577
151anterograde synaptic vesicle transport (GO:0048490)2.31333278
152vesicle fusion (GO:0006906)2.31310258
153glycerol ether metabolic process (GO:0006662)2.30894105
154response to type I interferon (GO:0034340)2.30713866
155lipid particle organization (GO:0034389)2.30258751
156regulation of natural killer cell differentiation (GO:0032823)2.28917908
157T cell migration (GO:0072678)2.28830925
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.28763793
159branched-chain amino acid metabolic process (GO:0009081)2.27875272
160cellular response to type I interferon (GO:0071357)2.27067423
161type I interferon signaling pathway (GO:0060337)2.27067423
162cellular response to exogenous dsRNA (GO:0071360)2.26103822
163striated muscle atrophy (GO:0014891)2.25816222
164positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.25080864
165fatty acid oxidation (GO:0019395)2.24282759
166lipid oxidation (GO:0034440)2.23907892
167peptide catabolic process (GO:0043171)2.23873583
168positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23544786
169Arp2/3 complex-mediated actin nucleation (GO:0034314)2.23489621
170tricarboxylic acid metabolic process (GO:0072350)2.23170181
171positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.23094485
172glyoxylate metabolic process (GO:0046487)2.22684192
173regulation of gamma-delta T cell differentiation (GO:0045586)2.19843387
174negative regulation of lipid storage (GO:0010888)2.18962465
175skeletal muscle adaptation (GO:0043501)2.18626016
176lipopolysaccharide-mediated signaling pathway (GO:0031663)2.17349129
177immunoglobulin mediated immune response (GO:0016064)2.17273262
178NADP metabolic process (GO:0006739)2.17104721
179hydrogen peroxide catabolic process (GO:0042744)2.15694072
180positive regulation of hemostasis (GO:1900048)2.13687578
181positive regulation of blood coagulation (GO:0030194)2.13687578
182short-chain fatty acid metabolic process (GO:0046459)2.13530552
183positive regulation by symbiont of host defense response (GO:0052509)2.12306350
184modulation by symbiont of host defense response (GO:0052031)2.12306350
185modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12306350
186modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.12306350
187positive regulation by organism of defense response of other organism involved in symbiotic interact2.12306350
188modulation by symbiont of host immune response (GO:0052553)2.12306350
1892-oxoglutarate metabolic process (GO:0006103)2.11587763
190drug transmembrane transport (GO:0006855)2.11160961
191response to peptidoglycan (GO:0032494)2.10541506
192positive regulation of coagulation (GO:0050820)2.09891153
193triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.09595918
194maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.09440278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.13678721
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.54207621
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.91368719
4GATA1_22025678_ChIP-Seq_K562_Human3.84165603
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.78612915
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.76211774
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.59526717
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.35042573
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11855265
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03651235
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.98312912
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94327351
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88815815
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.88522585
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.85149813
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.78676969
17* EST1_17652178_ChIP-ChIP_JURKAT_Human2.77147216
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72045237
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68543116
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58850378
21ELK1_19687146_ChIP-ChIP_HELA_Human2.54313297
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45963465
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.41789121
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.40429084
25* ETS1_20019798_ChIP-Seq_JURKAT_Human2.36582257
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.31162618
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28427004
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26779539
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25847089
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21557734
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20014025
32VDR_23849224_ChIP-Seq_CD4+_Human2.17402158
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.16312744
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11665655
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09912683
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07032508
37TRIM28_21343339_ChIP-Seq_HEK293_Human2.03510636
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00668590
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98977981
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98142791
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96816235
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96728021
43DCP1A_22483619_ChIP-Seq_HELA_Human1.93375828
44FOXP3_21729870_ChIP-Seq_TREG_Human1.81919076
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81895009
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80119287
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79667918
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79325656
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63011357
50* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62285417
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61053156
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60383411
53CLOCK_20551151_ChIP-Seq_293T_Human1.57995082
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56777415
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54124914
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54070859
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.54006283
58MYB_26560356_Chip-Seq_TH2_Human1.53922522
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52895095
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46673777
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46340357
62GABP_19822575_ChIP-Seq_HepG2_Human1.44883057
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44858728
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44715206
65SPI1_23547873_ChIP-Seq_NB4_Human1.43699603
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39696338
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35505224
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35395230
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34425070
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34175343
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34075109
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33327499
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32094893
74SCL_19346495_ChIP-Seq_HPC-7_Human1.29594986
75MAF_26560356_Chip-Seq_TH1_Human1.29483850
76RUNX_20019798_ChIP-Seq_JUKART_Human1.29424585
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29323546
78MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26610125
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26128775
80GATA1_19941826_ChIP-Seq_K562_Human1.24857938
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24144191
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.24097615
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23680485
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23469687
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22914504
86KDM5A_27292631_Chip-Seq_BREAST_Human1.22141163
87MYB_26560356_Chip-Seq_TH1_Human1.21874457
88SOX2_20726797_ChIP-Seq_SW620_Human1.21593183
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20747096
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20622133
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19831778
92ELF5_23300383_ChIP-Seq_T47D_Human1.17205514
93GATA3_27048872_Chip-Seq_THYMUS_Human1.17189417
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.17001123
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16907035
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16311691
97GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16291684
98TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16189284
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13058974
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12508133
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11698048
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08917767
103PU_27001747_Chip-Seq_BMDM_Mouse1.07811975
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07285046
105MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06916742
106MYC_18555785_ChIP-Seq_MESCs_Mouse1.06495603
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06459099
108SMAD_19615063_ChIP-ChIP_OVARY_Human1.05353833
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.05262268
110SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04089344
111GATA2_19941826_ChIP-Seq_K562_Human1.03104900
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03024060
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02787057
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02109441
115VDR_24763502_ChIP-Seq_THP-1_Human1.01748321
116CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01208806
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00994422
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.00776434
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00484279
120TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00424505
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00346956
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99967026
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99348670
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.98649700
125VDR_24787735_ChIP-Seq_THP-1_Human0.98425600
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.98301208
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98059308
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98045960
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97256570
130HTT_18923047_ChIP-ChIP_STHdh_Human0.97199633
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96046052
132GATA4_25053715_ChIP-Seq_YYC3_Human0.95565446
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95130987
134TFEB_21752829_ChIP-Seq_HELA_Human0.94908757
135GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94648276
136UTX_26944678_Chip-Seq_JUKART_Human0.93387833
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93330207
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91329121
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91273270
140ESR1_21235772_ChIP-Seq_MCF-7_Human0.90979332
141SALL4_22934838_ChIP-ChIP_CD34+_Human0.90095237
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89475316
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89380497
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89380497
145GATA3_26560356_Chip-Seq_TH2_Human0.89297711
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89241554
147EGR1_19032775_ChIP-ChIP_M12_Human0.88773117
148CDX2_22108803_ChIP-Seq_LS180_Human0.88630292
149PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88188048
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87759188
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87420138
152ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87273532
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85966538
154E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85556385
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84604319
156* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84449787
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82953488
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81385610

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation4.08044534
2MP0003950_abnormal_plasma_membrane2.86352982
3MP0001835_abnormal_antigen_presentation2.77219638
4MP0002139_abnormal_hepatobiliary_system2.77050813
5MP0006036_abnormal_mitochondrial_physio2.65861626
6MP0000685_abnormal_immune_system2.52568291
7MP0005058_abnormal_lysosome_morphology2.47673249
8MP0005360_urolithiasis2.41449154
9MP0009785_altered_susceptibility_to2.34167933
10MP0010234_abnormal_vibrissa_follicle2.33410574
11MP0003806_abnormal_nucleotide_metabolis2.32819555
12MP0002837_dystrophic_cardiac_calcinosis2.30631048
13MP0003436_decreased_susceptibility_to2.23654756
14MP0003724_increased_susceptibility_to2.21180401
15MP0003656_abnormal_erythrocyte_physiolo2.19094611
16MP0003195_calcinosis2.12814322
17MP0006082_CNS_inflammation2.02319738
18MP0000372_irregular_coat_pigmentation1.99900496
19MP0006054_spinal_hemorrhage1.98772441
20MP0000013_abnormal_adipose_tissue1.98192197
21MP0003300_gastrointestinal_ulcer1.93469911
22MP0004084_abnormal_cardiac_muscle1.92559372
23MP0002166_altered_tumor_susceptibility1.91280042
24MP0002148_abnormal_hypersensitivity_rea1.88358062
25MP0008875_abnormal_xenobiotic_pharmacok1.84693389
26MP0001727_abnormal_embryo_implantation1.83551591
27MP0008438_abnormal_cutaneous_collagen1.83327808
28MP0003186_abnormal_redox_activity1.83209747
29MP0003786_premature_aging1.82958812
30MP0002419_abnormal_innate_immunity1.82400932
31MP0005000_abnormal_immune_tolerance1.82237522
32MP0005025_abnormal_response_to1.81543777
33MP0004036_abnormal_muscle_relaxation1.80443709
34MP0005387_immune_system_phenotype1.79252741
35MP0001790_abnormal_immune_system1.79252741
36MP0003011_delayed_dark_adaptation1.76612775
37MP0009780_abnormal_chondrocyte_physiolo1.70237411
38MP0005330_cardiomyopathy1.69989117
39MP0004147_increased_porphyrin_level1.68761061
40MP0000749_muscle_degeneration1.67735536
41MP0005365_abnormal_bile_salt1.67419569
42MP0006035_abnormal_mitochondrial_morpho1.65921620
43MP0005085_abnormal_gallbladder_physiolo1.62118881
44MP0002006_tumorigenesis1.60705826
45MP0002138_abnormal_hepatobiliary_system1.58532582
46MP0001800_abnormal_humoral_immune1.55800426
47MP0001879_abnormal_lymphatic_vessel1.55455722
48MP0001533_abnormal_skeleton_physiology1.55349620
49MP0002452_abnormal_antigen_presenting1.55194551
50MP0001853_heart_inflammation1.55030431
51MP0005464_abnormal_platelet_physiology1.53543717
52MP0009643_abnormal_urine_homeostasis1.52528317
53MP0001958_emphysema1.52318699
54MP0005671_abnormal_response_to1.50989439
55MP0004145_abnormal_muscle_electrophysio1.50868531
56MP0005083_abnormal_biliary_tract1.49537980
57MP0009764_decreased_sensitivity_to1.47830725
58MP0000358_abnormal_cell_content/1.47400147
59MP0008058_abnormal_DNA_repair1.45862181
60MP0005332_abnormal_amino_acid1.45717192
61MP0003252_abnormal_bile_duct1.45143332
62MP0002723_abnormal_immune_serum1.44026601
63MP0001845_abnormal_inflammatory_respons1.41920639
64MP0003191_abnormal_cellular_cholesterol1.40100751
65MP0008469_abnormal_protein_level1.39694368
66MP0009840_abnormal_foam_cell1.39386116
67MP0004215_abnormal_myocardial_fiber1.38324192
68MP0004947_skin_inflammation1.37884667
69MP0008775_abnormal_heart_ventricle1.36232684
70MP0003221_abnormal_cardiomyocyte_apopto1.33551834
71MP0002420_abnormal_adaptive_immunity1.33354982
72MP0001819_abnormal_immune_cell1.33114688
73MP0005165_increased_susceptibility_to1.33112212
74MP0004019_abnormal_vitamin_homeostasis1.33002520
75MP0002405_respiratory_system_inflammati1.25148896
76MP0000609_abnormal_liver_physiology1.24296529
77MP0002332_abnormal_exercise_endurance1.23281172
78MP0002972_abnormal_cardiac_muscle1.21948864
79MP0003828_pulmonary_edema1.21130467
80MP0002877_abnormal_melanocyte_morpholog1.20346290
81MP0009763_increased_sensitivity_to1.20131263
82MP0003705_abnormal_hypodermis_morpholog1.20047883
83MP0000747_muscle_weakness1.18529618
84MP0003718_maternal_effect1.17721576
85MP0000465_gastrointestinal_hemorrhage1.16786738
86MP0005584_abnormal_enzyme/coenzyme_acti1.14096089
87MP0002933_joint_inflammation1.13942853
88MP0001873_stomach_inflammation1.13710837
89MP0004957_abnormal_blastocyst_morpholog1.11133525
90MP0001666_abnormal_nutrient_absorption1.10430979
91MP0010155_abnormal_intestine_physiology1.09188121
92MP0005319_abnormal_enzyme/_coenzyme1.08219533
93MP0010329_abnormal_lipoprotein_level1.08128797
94MP0005451_abnormal_body_composition1.07727054
95MP0001764_abnormal_homeostasis1.07084355
96MP0009333_abnormal_splenocyte_physiolog1.07050541
97MP0003763_abnormal_thymus_physiology1.05709749
98MP0002136_abnormal_kidney_physiology1.05125331
99MP0000858_altered_metastatic_potential1.04899568
100MP0000716_abnormal_immune_system1.04092485
101MP0000343_altered_response_to1.03053706
102MP0002398_abnormal_bone_marrow1.02056243
103MP0004484_altered_response_of1.02025584
104MP0002876_abnormal_thyroid_physiology1.00717987
105MP0003566_abnormal_cell_adhesion1.00034952
106MP0005408_hypopigmentation0.99995465
107MP0004185_abnormal_adipocyte_glucose0.99334643
108MP0001661_extended_life_span0.97910158
109MP0002998_abnormal_bone_remodeling0.97629602
110MP0002269_muscular_atrophy0.97398506
111MP0003303_peritoneal_inflammation0.97214013
112MP0002254_reproductive_system_inflammat0.94428446
113MP0003279_aneurysm0.94345044
114MP0002127_abnormal_cardiovascular_syste0.94106141
115MP0002971_abnormal_brown_adipose0.92272180
116MP0002429_abnormal_blood_cell0.92253248
117MP0000689_abnormal_spleen_morphology0.91782372
118MP0005666_abnormal_adipose_tissue0.91741651
119MP0000598_abnormal_liver_morphology0.91377919
120MP0008260_abnormal_autophagy0.91253482
121MP0002118_abnormal_lipid_homeostasis0.90147315
122MP0000604_amyloidosis0.89861107
123MP0005636_abnormal_mineral_homeostasis0.89539165
124MP0009384_cardiac_valve_regurgitation0.86706400
125MP0005075_abnormal_melanosome_morpholog0.86672007
126MP0003448_altered_tumor_morphology0.86634061
127MP0003868_abnormal_feces_composition0.85028064
128MP0005266_abnormal_metabolism0.84843267
129MP0000249_abnormal_blood_vessel0.84510999
130MP0003693_abnormal_embryo_hatching0.84297365
131MP0004043_abnormal_pH_regulation0.83254077
132MP0005395_other_phenotype0.83039645
133MP0002722_abnormal_immune_system0.82340763
134MP0002168_other_aberrant_phenotype0.81858396
135MP0003172_abnormal_lysosome_physiology0.81392867
136MP0001756_abnormal_urination0.80032802
137MP0000003_abnormal_adipose_tissue0.79191549
138MP0005084_abnormal_gallbladder_morpholo0.79182378
139MP0003646_muscle_fatigue0.78209436
140MP0005410_abnormal_fertilization0.78071597
141MP0004130_abnormal_muscle_cell0.76608011
142MP0004510_myositis0.75913882
143MP0010368_abnormal_lymphatic_system0.75562378
144MP0003795_abnormal_bone_structure0.74467732
145MP0001544_abnormal_cardiovascular_syste0.74319001
146MP0005385_cardiovascular_system_phenoty0.74319001
147MP0005620_abnormal_muscle_contractility0.73587744
148MP0002295_abnormal_pulmonary_circulatio0.72479572
149MP0005220_abnormal_exocrine_pancreas0.71890590
150MP0004233_abnormal_muscle_weight0.71415785
151MP0005376_homeostasis/metabolism_phenot0.71373017
152MP0009765_abnormal_xenobiotic_induced0.71256801
153MP0004272_abnormal_basement_membrane0.70114405
154MP0005164_abnormal_response_to0.69460746
155MP0004087_abnormal_muscle_fiber0.68397973
156MP0010386_abnormal_urinary_bladder0.66807716
157MP0001730_embryonic_growth_arrest0.66005877
158MP0009115_abnormal_fat_cell0.59597390

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)4.20670283
2Recurrent gram-negative bacterial infections (HP:0005420)4.20378050
3Eczematoid dermatitis (HP:0000976)3.95397845
4Fatigue (HP:0012378)3.78380782
5Progressive external ophthalmoplegia (HP:0000590)3.76555266
6Vacuolated lymphocytes (HP:0001922)3.62719951
7Recurrent abscess formation (HP:0002722)3.43061830
8Sensory axonal neuropathy (HP:0003390)3.41922840
9Recurrent bacterial skin infections (HP:0005406)3.36378625
10Ragged-red muscle fibers (HP:0003200)3.23056429
11Hepatic necrosis (HP:0002605)3.19858185
12Nemaline bodies (HP:0003798)3.17534112
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.14981709
14Progressive muscle weakness (HP:0003323)3.14767224
15Generalized aminoaciduria (HP:0002909)3.08917970
16Abnormality of macrophages (HP:0004311)2.96529637
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94680352
18Hypokinesia (HP:0002375)2.94516581
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.94511759
20Hypoglycemic coma (HP:0001325)2.94104894
21Vascular calcification (HP:0004934)2.93079251
22EMG: myopathic abnormalities (HP:0003458)2.92709973
23Muscle fiber inclusion bodies (HP:0100299)2.91701129
24Xanthomatosis (HP:0000991)2.82950387
25Cardiovascular calcification (HP:0011915)2.82553401
26Autoimmune hemolytic anemia (HP:0001890)2.78006511
27Metaphyseal dysplasia (HP:0100255)2.68937878
28Abnormality of fatty-acid metabolism (HP:0004359)2.67754449
29Increased intramyocellular lipid droplets (HP:0012240)2.67625652
30Increased serum pyruvate (HP:0003542)2.65921610
31Abnormal mitochondria in muscle tissue (HP:0008316)2.65400147
32Myocardial infarction (HP:0001658)2.64011875
33Amniotic constriction ring (HP:0009775)2.62765549
34Abnormality of placental membranes (HP:0011409)2.62765549
35Elevated erythrocyte sedimentation rate (HP:0003565)2.62282038
36Abnormality of purine metabolism (HP:0004352)2.61487385
37Paralysis (HP:0003470)2.60458123
38Deep venous thrombosis (HP:0002625)2.55413425
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53714879
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53714879
41Increased muscle lipid content (HP:0009058)2.53590393
42Nausea (HP:0002018)2.53217544
43Dicarboxylic aciduria (HP:0003215)2.53118056
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53118056
45Hypoalphalipoproteinemia (HP:0003233)2.52253047
46Acute necrotizing encephalopathy (HP:0006965)2.51637026
47Dysostosis multiplex (HP:0000943)2.51494832
48Recurrent viral infections (HP:0004429)2.50668001
49Rhabdomyolysis (HP:0003201)2.49490489
50Recurrent skin infections (HP:0001581)2.48534012
51Mitochondrial inheritance (HP:0001427)2.48382866
52Exercise intolerance (HP:0003546)2.46549059
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45230048
54Hepatocellular necrosis (HP:0001404)2.44408916
55Increased CSF lactate (HP:0002490)2.43744935
56Proximal tubulopathy (HP:0000114)2.43235856
57Complement deficiency (HP:0004431)2.42575035
58Ketosis (HP:0001946)2.41125902
59Steatorrhea (HP:0002570)2.40026752
60Cholelithiasis (HP:0001081)2.38350639
61Abnormality of glycolysis (HP:0004366)2.36479558
62Aortic aneurysm (HP:0004942)2.34568537
63Poikilocytosis (HP:0004447)2.34296538
64Systemic lupus erythematosus (HP:0002725)2.34092881
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.33795249
66Osteolytic defects of the hand bones (HP:0009699)2.33795249
67Abnormality of the common coagulation pathway (HP:0010990)2.33445140
68Tetraparesis (HP:0002273)2.32851468
69Abnormal hemoglobin (HP:0011902)2.31432192
70Abnormality of liposaccharide metabolism (HP:0010968)2.30052075
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.30052075
72Abnormality of glycolipid metabolism (HP:0010969)2.30052075
73Premature ovarian failure (HP:0008209)2.29952131
74Chronic otitis media (HP:0000389)2.29804172
75Abnormal gallbladder morphology (HP:0012437)2.29530911
76Urticaria (HP:0001025)2.29453320
77Progressive macrocephaly (HP:0004481)2.25901970
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24808661
79Gingivitis (HP:0000230)2.24179867
80Recurrent fungal infections (HP:0002841)2.23283555
81Polycythemia (HP:0001901)2.21806976
82Cerebral hemorrhage (HP:0001342)2.19568927
83Palpitations (HP:0001962)2.19400785
84Acute encephalopathy (HP:0006846)2.18439271
85Abnormality of T cell number (HP:0011839)2.15384959
86Exercise-induced myalgia (HP:0003738)2.13745246
87Hyperammonemia (HP:0001987)2.10895840
88Cerebral edema (HP:0002181)2.10260008
89Recurrent pneumonia (HP:0006532)2.09786332
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.09139981
91Myoglobinuria (HP:0002913)2.09078155
92Reduced antithrombin III activity (HP:0001976)2.06591044
93Purpura (HP:0000979)2.06567150
94Joint hemorrhage (HP:0005261)2.06538721
95Interstitial pulmonary disease (HP:0006530)2.06526137
96Abnormality of nucleobase metabolism (HP:0010932)2.06483443
97Hypolipoproteinemia (HP:0010981)2.05362387
98Intrahepatic cholestasis (HP:0001406)2.04276204
99Increased serum lactate (HP:0002151)2.04262286
100Asymmetric septal hypertrophy (HP:0001670)2.04223469
101Fat malabsorption (HP:0002630)2.03806106
102Renal Fanconi syndrome (HP:0001994)2.02590626
103Petechiae (HP:0000967)2.01753852
104Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01700913
105Ketoacidosis (HP:0001993)2.01378054
106Impaired proprioception (HP:0010831)1.99700819
107Popliteal pterygium (HP:0009756)1.98877345
108Abnormality of sulfur amino acid metabolism (HP:0004339)1.98713411
109Hyporeflexia of lower limbs (HP:0002600)1.98640221
110Lactic acidosis (HP:0003128)1.98604895
111Hydroxyprolinuria (HP:0003080)1.98190368
112Abnormality of proline metabolism (HP:0010907)1.98190368
113Cellulitis (HP:0100658)1.97372966
114Lipid accumulation in hepatocytes (HP:0006561)1.97168748
115Mediastinal lymphadenopathy (HP:0100721)1.96205280
116Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95570474
117Abnormality of lateral ventricle (HP:0030047)1.95469571
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94838143
119Renal cortical cysts (HP:0000803)1.94426761
120Prolonged partial thromboplastin time (HP:0003645)1.94375403
121Urinary glycosaminoglycan excretion (HP:0003541)1.94045019
122Mucopolysacchariduria (HP:0008155)1.94045019
123Metaphyseal cupping (HP:0003021)1.92579534
124Abnormality of the intrinsic pathway (HP:0010989)1.91964527
125Increased hepatocellular lipid droplets (HP:0006565)1.91867608
126Hyperphosphatemia (HP:0002905)1.91699166
127Orthostatic hypotension (HP:0001278)1.91687622
128Abnormality of glycine metabolism (HP:0010895)1.91538150
129Abnormality of serine family amino acid metabolism (HP:0010894)1.91538150
130Hypertriglyceridemia (HP:0002155)1.90840027
131Abnormality of complement system (HP:0005339)1.89300721
132Recurrent lower respiratory tract infections (HP:0002783)1.89212902
133Esophageal varix (HP:0002040)1.89196917
134Myositis (HP:0100614)1.87880095
135Hyperlipoproteinemia (HP:0010980)1.87008635
136Acanthocytosis (HP:0001927)1.86714272
137Beaking of vertebral bodies (HP:0004568)1.86611027
138Vertebral compression fractures (HP:0002953)1.86562247
139Cholecystitis (HP:0001082)1.86407331
140Abnormal gallbladder physiology (HP:0012438)1.86407331
141Osteomyelitis (HP:0002754)1.86176351
142Lethargy (HP:0001254)1.86124014
143Hyperglycinemia (HP:0002154)1.85464970
144Glycosuria (HP:0003076)1.85058871
145Abnormality of urine glucose concentration (HP:0011016)1.85058871
146Ileus (HP:0002595)1.84978146
147Hyperbilirubinemia (HP:0002904)1.84557358
148Neuroendocrine neoplasm (HP:0100634)1.84492758
149Methylmalonic acidemia (HP:0002912)1.83154803
150Spondylolisthesis (HP:0003302)1.82750179
151Abnormality of alanine metabolism (HP:0010916)1.82388405
152Hyperalaninemia (HP:0003348)1.82388405
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82388405
154Recurrent bronchitis (HP:0002837)1.81714784
155Progressive neurologic deterioration (HP:0002344)1.81101886
156Hepatocellular carcinoma (HP:0001402)1.80742404
157Bundle branch block (HP:0011710)1.80443710
158Exercise-induced muscle cramps (HP:0003710)1.80226194
159Increased purine levels (HP:0004368)1.80206691
160Hyperuricemia (HP:0002149)1.80206691
161CNS demyelination (HP:0007305)1.78990009
162Metabolic acidosis (HP:0001942)1.78766730
163T lymphocytopenia (HP:0005403)1.78187744
164Hemorrhage of the eye (HP:0011885)1.77078512
165Axonal loss (HP:0003447)1.75811423
166Progressive hearing impairment (HP:0001730)1.75371329
167Abnormality of T cell physiology (HP:0011840)1.75355982
168Peritonitis (HP:0002586)1.74302066
169Abnormality of polysaccharide metabolism (HP:0011012)1.73696286
170Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73696286
171Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73696286
172Vasculitis (HP:0002633)1.72828506
173Respiratory failure (HP:0002878)1.72589404
174Muscle hypertrophy of the lower extremities (HP:0008968)1.72058854
175Calf muscle hypertrophy (HP:0008981)1.71429417
176Abnormality of the gallbladder (HP:0005264)1.71423377
177Type I transferrin isoform profile (HP:0003642)1.71080999
178Pathologic fracture (HP:0002756)1.71010291
179Distal arthrogryposis (HP:0005684)1.70634913
180Abnormal protein glycosylation (HP:0012346)1.69507001
181Abnormal glycosylation (HP:0012345)1.69507001
182Abnormal protein N-linked glycosylation (HP:0012347)1.69507001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.43876740
2MAP3K123.14214762
3NEK12.92007890
4MAP3K142.70531088
5MAP4K12.28270247
6TBK12.28017564
7ERN12.20508170
8TYK22.17459228
9IRAK42.15319947
10NEK92.10014007
11PDK22.04658811
12BCKDK2.01637340
13IRAK31.99893938
14MAP3K31.99840766
15TXK1.99046045
16MST41.98286862
17STK101.97444179
18PBK1.97270954
19TIE11.97135949
20JAK31.95170868
21FLT31.84401767
22LMTK21.84304843
23MAP3K21.84064619
24PIK3CG1.72798571
25TTN1.72618062
26JAK11.72457503
27FGFR41.71306026
28EPHB11.71184995
29LRRK21.71073059
30TAOK31.68117326
31IKBKE1.66337083
32TEC1.63815736
33TRIM281.59635091
34TRPM71.56608435
35ZAP701.55208187
36KIT1.48298499
37CAMK1D1.48073754
38MAPKAPK31.40108477
39EPHA31.37224206
40FRK1.36783011
41TRIB31.35670453
42PTK61.35606802
43CSK1.35076506
44NME21.32460867
45KDR1.31783918
46BLK1.28216264
47ITK1.26173003
48MAP4K21.24977505
49BTK1.22810337
50IKBKB1.20348770
51SIK11.18622187
52PIK3CA1.16809120
53RPS6KA41.15116990
54RAF11.14035282
55SYK1.12301099
56WNK41.12098385
57CCNB11.09511957
58ERBB31.09404867
59NUAK11.08903666
60EPHA21.03464289
61PKN21.03214421
62KSR21.01792957
63TESK11.01409205
64CSF1R0.97581093
65MYLK0.97312410
66PRKCQ0.95782001
67JAK20.94455222
68MAPKAPK50.93905007
69TGFBR20.92925515
70ARAF0.92147498
71LCK0.90870587
72MELK0.90468960
73STK40.88846532
74PAK40.88782044
75RPS6KB20.88245064
76OBSCN0.86637554
77AKT20.84689064
78STK160.84536172
79MAP2K10.84293017
80PHKG10.83458722
81PHKG20.83458722
82EIF2AK10.83292521
83ABL20.81795459
84MST1R0.81736896
85MAP2K30.79257067
86LYN0.79027683
87CHUK0.78228292
88IRAK10.78158761
89TSSK60.75705269
90ILK0.75498029
91LIMK10.74526251
92HCK0.74373894
93PIM10.73991695
94TTK0.71689872
95PRKG20.71656081
96MARK30.71439663
97BMX0.69568824
98TLK10.69065854
99FER0.68636362
100DYRK30.67244152
101SCYL20.67079437
102FGFR30.66372928
103STK240.65736634
104RIPK10.64631961
105MAP3K130.62995682
106MAPK110.62379089
107MAP3K80.61426613
108MET0.60549923
109TESK20.58215027
110ACVR1B0.57803536
111MAP3K50.57534134
112PLK10.57262284
113PRKD20.57262014
114MAPKAPK20.56899711
115STK30.55895342
116GRK70.55426319
117PLK30.53941125
118BRSK20.52656414
119PRKCD0.50383042
120PRKD10.48766871
121BMPR20.48546662
122STK390.48366553
123IGF1R0.48311335
124EGFR0.47959235
125CAMKK20.46155075
126BUB10.46136323
127PAK30.42990098
128PRKCH0.42893326
129PDK10.42535448
130MAP3K10.42209201
131PRKAA20.41715677
132RIPK40.41484413
133KSR10.40168661
134PDPK10.40102572
135DYRK1B0.40048618
136CSNK1A1L0.39756574
137STK380.39701563
138INSR0.39655259
139PTK2B0.39520562
140FES0.39139445
141PIM20.38196400
142CAMK1G0.37132355
143ZAK0.36683845
144CSNK1G30.36605878
145ABL10.36511995
146INSRR0.36315485
147BRAF0.34083514
148SRPK10.33240469
149PRKACB0.32662995
150TAOK20.31508896
151PAK10.30996758
152CLK10.30203093
153DAPK30.27937504
154PRKCI0.27770425
155PLK20.27396809
156CSNK2A10.26882486
157DAPK10.26873392
158TAOK10.25398926

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.72239708
2Proteasome_Homo sapiens_hsa030504.83117401
3Oxidative phosphorylation_Homo sapiens_hsa001902.48754731
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21960693
5Parkinsons disease_Homo sapiens_hsa050122.21280038
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.08957768
7Staphylococcus aureus infection_Homo sapiens_hsa051502.07567749
8Basal transcription factors_Homo sapiens_hsa030222.06323180
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.95025054
10Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.94389956
11Fatty acid degradation_Homo sapiens_hsa000711.92048839
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90861092
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88078879
14Graft-versus-host disease_Homo sapiens_hsa053321.78318444
15Sulfur metabolism_Homo sapiens_hsa009201.78288758
16Tryptophan metabolism_Homo sapiens_hsa003801.75973644
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74144540
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68844921
19Complement and coagulation cascades_Homo sapiens_hsa046101.67125829
20Peroxisome_Homo sapiens_hsa041461.65790459
21Collecting duct acid secretion_Homo sapiens_hsa049661.64939636
22Malaria_Homo sapiens_hsa051441.54050933
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53858975
24Propanoate metabolism_Homo sapiens_hsa006401.53794204
25Legionellosis_Homo sapiens_hsa051341.51900150
26Leishmaniasis_Homo sapiens_hsa051401.50413495
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49986600
28Other glycan degradation_Homo sapiens_hsa005111.48491304
29Lysosome_Homo sapiens_hsa041421.45131792
30Selenocompound metabolism_Homo sapiens_hsa004501.43560470
31Antigen processing and presentation_Homo sapiens_hsa046121.42190172
32Protein export_Homo sapiens_hsa030601.40715185
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40342783
34Alzheimers disease_Homo sapiens_hsa050101.38145351
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.38138789
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37736341
37Fatty acid metabolism_Homo sapiens_hsa012121.36905922
38Starch and sucrose metabolism_Homo sapiens_hsa005001.34970350
39Huntingtons disease_Homo sapiens_hsa050161.34878493
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34627359
41PPAR signaling pathway_Homo sapiens_hsa033201.34206449
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.26751393
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.23339148
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17964067
45ABC transporters_Homo sapiens_hsa020101.17862328
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17025902
47Nucleotide excision repair_Homo sapiens_hsa034201.16247149
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16115037
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14463453
50Vibrio cholerae infection_Homo sapiens_hsa051101.12201565
51Chemical carcinogenesis_Homo sapiens_hsa052041.11828111
52beta-Alanine metabolism_Homo sapiens_hsa004101.09267837
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08928331
54Arginine biosynthesis_Homo sapiens_hsa002201.08419516
55Histidine metabolism_Homo sapiens_hsa003401.08153450
56Non-homologous end-joining_Homo sapiens_hsa034501.08117715
57Primary immunodeficiency_Homo sapiens_hsa053401.05084447
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04554677
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04364184
60Allograft rejection_Homo sapiens_hsa053301.04061269
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01355341
62Measles_Homo sapiens_hsa051620.99984802
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99975190
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97787241
65Rheumatoid arthritis_Homo sapiens_hsa053230.96216611
66RNA polymerase_Homo sapiens_hsa030200.95801520
67Fatty acid elongation_Homo sapiens_hsa000620.94576679
68Mismatch repair_Homo sapiens_hsa034300.94441851
69Hematopoietic cell lineage_Homo sapiens_hsa046400.94412994
70Nitrogen metabolism_Homo sapiens_hsa009100.93039868
71Galactose metabolism_Homo sapiens_hsa000520.92108987
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90847736
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90647660
74Sphingolipid metabolism_Homo sapiens_hsa006000.89911322
75Glutathione metabolism_Homo sapiens_hsa004800.89502039
76Phenylalanine metabolism_Homo sapiens_hsa003600.84826628
77Pertussis_Homo sapiens_hsa051330.84093482
78Circadian rhythm_Homo sapiens_hsa047100.83871767
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.83075660
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82800369
81N-Glycan biosynthesis_Homo sapiens_hsa005100.81486531
82Osteoclast differentiation_Homo sapiens_hsa043800.80381735
83One carbon pool by folate_Homo sapiens_hsa006700.80199304
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80093593
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79615557
86Tyrosine metabolism_Homo sapiens_hsa003500.79269840
87Steroid biosynthesis_Homo sapiens_hsa001000.78985084
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78266700
89Renin-angiotensin system_Homo sapiens_hsa046140.78177829
90Carbon metabolism_Homo sapiens_hsa012000.77868316
91Butanoate metabolism_Homo sapiens_hsa006500.75470453
92Pyrimidine metabolism_Homo sapiens_hsa002400.75199433
93Metabolic pathways_Homo sapiens_hsa011000.74864873
94Tuberculosis_Homo sapiens_hsa051520.74602806
95Vitamin digestion and absorption_Homo sapiens_hsa049770.73831732
96Phagosome_Homo sapiens_hsa041450.73738069
97Folate biosynthesis_Homo sapiens_hsa007900.72035560
98Apoptosis_Homo sapiens_hsa042100.70612573
99Influenza A_Homo sapiens_hsa051640.70552267
100TNF signaling pathway_Homo sapiens_hsa046680.69292833
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.66642776
102Pentose phosphate pathway_Homo sapiens_hsa000300.66075527
103Toxoplasmosis_Homo sapiens_hsa051450.65274611
104Fat digestion and absorption_Homo sapiens_hsa049750.64648861
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64620020
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.64614502
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62283435
108Systemic lupus erythematosus_Homo sapiens_hsa053220.62129886
109Retinol metabolism_Homo sapiens_hsa008300.61773067
110Cardiac muscle contraction_Homo sapiens_hsa042600.60976754
111Homologous recombination_Homo sapiens_hsa034400.58139866
112Dorso-ventral axis formation_Homo sapiens_hsa043200.58065402
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.56342227
114Pyruvate metabolism_Homo sapiens_hsa006200.55584925
115Hepatitis C_Homo sapiens_hsa051600.55421313
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54687691
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.54644195
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54159119
119Glycerolipid metabolism_Homo sapiens_hsa005610.53535071
120Insulin resistance_Homo sapiens_hsa049310.53442626
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53311208
122African trypanosomiasis_Homo sapiens_hsa051430.52986665
123Herpes simplex infection_Homo sapiens_hsa051680.51316140
124Purine metabolism_Homo sapiens_hsa002300.50999975
125Biosynthesis of amino acids_Homo sapiens_hsa012300.50968648
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.50474689
127Arginine and proline metabolism_Homo sapiens_hsa003300.49846016
128Bile secretion_Homo sapiens_hsa049760.47931152
129B cell receptor signaling pathway_Homo sapiens_hsa046620.47798174
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.47363751
131Fructose and mannose metabolism_Homo sapiens_hsa000510.46247659
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45992033
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45170802
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43884362
135Salmonella infection_Homo sapiens_hsa051320.43870671
136Asthma_Homo sapiens_hsa053100.43175627
137Viral myocarditis_Homo sapiens_hsa054160.42533915
138Autoimmune thyroid disease_Homo sapiens_hsa053200.42466007
139Type I diabetes mellitus_Homo sapiens_hsa049400.42177955
140p53 signaling pathway_Homo sapiens_hsa041150.38259151
141Mineral absorption_Homo sapiens_hsa049780.37283763
142* Regulation of autophagy_Homo sapiens_hsa041400.35095351
143RNA transport_Homo sapiens_hsa030130.35088300
144Shigellosis_Homo sapiens_hsa051310.34387322
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.33083867
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31044034

Most similar genes based on co-expression Upload to Enrichr

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