ATG4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.97087598
2L-phenylalanine metabolic process (GO:0006558)4.72960293
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.72960293
4lysine catabolic process (GO:0006554)4.55258319
5lysine metabolic process (GO:0006553)4.55258319
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.45493036
7serine family amino acid catabolic process (GO:0009071)4.14612044
8glycine metabolic process (GO:0006544)4.14271242
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.12260258
10L-phenylalanine catabolic process (GO:0006559)4.12260258
11cysteine metabolic process (GO:0006534)4.07075714
12heme biosynthetic process (GO:0006783)4.00787847
13sulfur amino acid catabolic process (GO:0000098)3.94628637
14amino-acid betaine metabolic process (GO:0006577)3.89703931
15porphyrin-containing compound biosynthetic process (GO:0006779)3.87687093
163-UTR-mediated mRNA stabilization (GO:0070935)3.86755755
17GDP-mannose metabolic process (GO:0019673)3.82656282
18glyoxylate metabolic process (GO:0046487)3.77358578
19protoporphyrinogen IX metabolic process (GO:0046501)3.76940556
20creatine metabolic process (GO:0006600)3.75388782
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.72134848
222-oxoglutarate metabolic process (GO:0006103)3.67499729
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65122141
24negative regulation of cell killing (GO:0031342)3.65122141
25NADH metabolic process (GO:0006734)3.63237839
26aromatic amino acid family catabolic process (GO:0009074)3.61561710
27serine family amino acid metabolic process (GO:0009069)3.55955273
28kynurenine metabolic process (GO:0070189)3.55652719
29homocysteine metabolic process (GO:0050667)3.54586889
30tetrapyrrole biosynthetic process (GO:0033014)3.53718937
31aspartate family amino acid catabolic process (GO:0009068)3.46519736
32NIK/NF-kappaB signaling (GO:0038061)3.43308284
33fatty acid beta-oxidation (GO:0006635)3.42217842
34folic acid metabolic process (GO:0046655)3.40750780
35viral transcription (GO:0019083)3.39634161
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38296090
37protoporphyrinogen IX biosynthetic process (GO:0006782)3.36674115
38carnitine metabolic process (GO:0009437)3.35868252
39heme metabolic process (GO:0042168)3.34569434
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32046529
41valine metabolic process (GO:0006573)3.30534859
42tricarboxylic acid cycle (GO:0006099)3.29746467
43regulation of triglyceride catabolic process (GO:0010896)3.29411322
44regulation of cholesterol homeostasis (GO:2000188)3.28857987
45porphyrin-containing compound metabolic process (GO:0006778)3.28550412
46positive regulation of lipoprotein lipase activity (GO:0051006)3.26452495
47positive regulation of triglyceride lipase activity (GO:0061365)3.26452495
48translational termination (GO:0006415)3.21489749
49apoptotic process involved in morphogenesis (GO:0060561)3.21037380
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20977854
51indole-containing compound catabolic process (GO:0042436)3.19896537
52indolalkylamine catabolic process (GO:0046218)3.19896537
53tryptophan catabolic process (GO:0006569)3.19896537
54serine family amino acid biosynthetic process (GO:0009070)3.18691222
55negative regulation of necroptotic process (GO:0060546)3.17994930
56mucosal-associated lymphoid tissue development (GO:0048537)3.17356552
57Peyers patch development (GO:0048541)3.17356552
58negative regulation of cholesterol transport (GO:0032375)3.17347763
59negative regulation of sterol transport (GO:0032372)3.17347763
60fatty acid oxidation (GO:0019395)3.17051338
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16667484
62oxidative phosphorylation (GO:0006119)3.15783612
63antigen processing and presentation of endogenous antigen (GO:0019883)3.14205587
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12156607
65cellular ketone body metabolic process (GO:0046950)3.11072375
66cellular response to virus (GO:0098586)3.10568414
67regulation of necrotic cell death (GO:0010939)3.10304085
68modulation by virus of host process (GO:0019054)3.09346833
69alpha-amino acid catabolic process (GO:1901606)3.09196381
70bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08994790
71lipid oxidation (GO:0034440)3.08297973
72proline biosynthetic process (GO:0006561)3.08215144
73carnitine shuttle (GO:0006853)3.07387458
74translational elongation (GO:0006414)3.06147017
75fatty acid catabolic process (GO:0009062)3.05221681
76positive regulation of gamma-delta T cell activation (GO:0046645)3.03608022
77urea cycle (GO:0000050)3.03547261
78urea metabolic process (GO:0019627)3.03547261
79response to peptidoglycan (GO:0032494)3.03107004
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.01983362
81intestinal cholesterol absorption (GO:0030299)3.00922910
82oxaloacetate metabolic process (GO:0006107)2.98132472
83tryptophan metabolic process (GO:0006568)2.97766623
84short-chain fatty acid metabolic process (GO:0046459)2.97617264
85tricarboxylic acid metabolic process (GO:0072350)2.97348088
86aromatic amino acid family metabolic process (GO:0009072)2.96421915
87fatty acid transmembrane transport (GO:1902001)2.96252924
88cellular amino acid catabolic process (GO:0009063)2.95350430
89modulation by symbiont of host cellular process (GO:0044068)2.95194352
90phospholipid efflux (GO:0033700)2.93579375
91positive thymic T cell selection (GO:0045059)2.93102394
92positive regulation of triglyceride metabolic process (GO:0090208)2.91856727
93activation of MAPKKK activity (GO:0000185)2.91372366
94acetyl-CoA metabolic process (GO:0006084)2.90404151
95regulation of necroptotic process (GO:0060544)2.90288262
96galactose catabolic process (GO:0019388)2.89630485
97detection of bacterium (GO:0016045)2.89604989
98negative regulation of fatty acid biosynthetic process (GO:0045717)2.87800859
99pentose-phosphate shunt (GO:0006098)2.87773238
100response to mercury ion (GO:0046689)2.86195991
101high-density lipoprotein particle remodeling (GO:0034375)2.85871116
102nucleoside diphosphate biosynthetic process (GO:0009133)2.85851233
103oxygen transport (GO:0015671)2.85340517
104positive regulation of Cdc42 GTPase activity (GO:0043089)2.85139758
105nitrogen cycle metabolic process (GO:0071941)2.85042659
106regulation of gamma-delta T cell differentiation (GO:0045586)2.84950172
107fructose metabolic process (GO:0006000)2.83137934
108skeletal muscle contraction (GO:0003009)2.83108958
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82235019
1104-hydroxyproline metabolic process (GO:0019471)2.81891081
111drug catabolic process (GO:0042737)2.81700298
112regulation of fatty acid oxidation (GO:0046320)2.81385622
113ethanol oxidation (GO:0006069)2.81245149
114negative regulation of fibrinolysis (GO:0051918)2.80668876
115maternal placenta development (GO:0001893)2.80543227
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80346531
117pyrimidine nucleoside catabolic process (GO:0046135)2.80261558
118nucleoside salvage (GO:0043174)2.79222790
119monocarboxylic acid catabolic process (GO:0072329)2.78664565
120DNA deamination (GO:0045006)2.78378922
121carboxylic acid catabolic process (GO:0046395)2.78278396
122organic acid catabolic process (GO:0016054)2.78278396
123regulation of cholesterol metabolic process (GO:0090181)2.78092577
124ATP synthesis coupled proton transport (GO:0015986)2.77899754
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77899754
126leukocyte aggregation (GO:0070486)2.76662640
127nucleotide salvage (GO:0043173)2.76161754
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76154376
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.76154376
130modulation by symbiont of host immune response (GO:0052553)2.76154376
131positive regulation by symbiont of host defense response (GO:0052509)2.76154376
132modulation by symbiont of host defense response (GO:0052031)2.76154376
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76154376
134regulation of gamma-delta T cell activation (GO:0046643)2.74667962
135bile acid biosynthetic process (GO:0006699)2.74180827
136protein targeting to ER (GO:0045047)2.74092964
137pyrimidine-containing compound salvage (GO:0008655)2.73418533
138pyrimidine nucleoside salvage (GO:0043097)2.73418533
139plasma lipoprotein particle assembly (GO:0034377)2.73407270
140amino-acid betaine transport (GO:0015838)2.72850387
141carnitine transport (GO:0015879)2.72850387
142negative regulation of cell size (GO:0045792)2.72459608
143respiratory electron transport chain (GO:0022904)2.72300400
144erythrocyte maturation (GO:0043249)2.71500236
145ribosomal small subunit biogenesis (GO:0042274)2.69638564
146regulation of early endosome to late endosome transport (GO:2000641)2.69259627
147embryonic process involved in female pregnancy (GO:0060136)2.67794385
148detection of other organism (GO:0098543)2.67625312
149regulation of chromatin binding (GO:0035561)2.66493905
150deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65396348
151intracellular estrogen receptor signaling pathway (GO:0030520)2.64832344
152thymic T cell selection (GO:0045061)2.63073995
153barbed-end actin filament capping (GO:0051016)2.62583459
154negative regulation of viral release from host cell (GO:1902187)2.59922210
155mannose metabolic process (GO:0006013)2.55800753
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.55777657
157positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51028966
158germinal center formation (GO:0002467)2.48483511
159intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.47150967
160pentose metabolic process (GO:0019321)2.43174268
161granulocyte differentiation (GO:0030851)2.42610263
162gas transport (GO:0015669)2.41413159
163negative regulation of myotube differentiation (GO:0010832)2.41303118
164regulation of interferon-beta biosynthetic process (GO:0045357)2.40219587
165purine nucleotide salvage (GO:0032261)2.38250598
166response to muramyl dipeptide (GO:0032495)2.38231474
167endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.36849279
168glucose catabolic process (GO:0006007)2.36846107
169mature B cell differentiation involved in immune response (GO:0002313)2.36584333
170negative regulation of necrotic cell death (GO:0060547)2.36366698
171regulation of superoxide anion generation (GO:0032928)2.36003594
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35970222
173negative regulation of toll-like receptor signaling pathway (GO:0034122)2.34345595
174actin-myosin filament sliding (GO:0033275)2.32500205
175muscle filament sliding (GO:0030049)2.32500205
176regulation of mast cell degranulation (GO:0043304)2.32047253
177erythrocyte development (GO:0048821)2.31809387
178regulation of leukocyte degranulation (GO:0043300)2.30523610
179NADPH regeneration (GO:0006740)2.30101737
180regulation of NFAT protein import into nucleus (GO:0051532)2.30041291
181negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.28250604
182pinocytosis (GO:0006907)2.28195940
183lipopolysaccharide-mediated signaling pathway (GO:0031663)2.28068516
184regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28049127
185epithelial cell differentiation involved in prostate gland development (GO:0060742)2.27909489
186gluconeogenesis (GO:0006094)2.27734890
187cellular response to arsenic-containing substance (GO:0071243)2.25700511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.74137274
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.79637824
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.48053982
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42193923
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.41212351
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.50779506
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.33593903
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23994265
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11880910
10ZNF263_19887448_ChIP-Seq_K562_Human2.09031505
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06471871
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.03064758
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01900545
14KDM2B_26808549_Chip-Seq_DND41_Human1.99779574
15EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98519531
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.95493200
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87242531
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81970689
19MYC_22102868_ChIP-Seq_BL_Human1.79862301
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77160933
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75772228
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.75373165
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75156396
24SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75005180
25VDR_24763502_ChIP-Seq_THP-1_Human1.74441947
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74062890
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71635006
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68045883
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65475692
30CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63175646
31VDR_21846776_ChIP-Seq_THP-1_Human1.60277225
32LXR_22292898_ChIP-Seq_THP-1_Human1.57535051
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56848048
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54933853
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54600223
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53886424
37* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53323105
38GATA1_22025678_ChIP-Seq_K562_Human1.50267969
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.45568749
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.45495170
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.45422675
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43102599
43NCOR1_26117541_ChIP-Seq_K562_Human1.40808866
44XRN2_22483619_ChIP-Seq_HELA_Human1.39690387
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.38356854
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37650867
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36825561
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.34027272
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32747430
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31936842
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31424520
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31175117
53DCP1A_22483619_ChIP-Seq_HELA_Human1.29512813
54* CREB1_26743006_Chip-Seq_LNCaP_Human1.29282890
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28266664
56BCOR_27268052_Chip-Seq_Bcells_Human1.27829025
57SMC4_20622854_ChIP-Seq_HELA_Human1.26130156
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.26072629
59KDM2B_26808549_Chip-Seq_K562_Human1.25869196
60RACK7_27058665_Chip-Seq_MCF-7_Human1.24899243
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.24810024
62ATF3_27146783_Chip-Seq_COLON_Human1.23834399
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23279470
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23043298
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22899165
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22702831
67* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22021784
68SCL_19346495_ChIP-Seq_HPC-7_Human1.21610159
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21375293
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21104906
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.20789898
72* P68_20966046_ChIP-Seq_HELA_Human1.19835042
73GATA1_19941826_ChIP-Seq_K562_Human1.18881624
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18862767
75BCL6_27268052_Chip-Seq_Bcells_Human1.18807111
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18674295
77* TET1_21451524_ChIP-Seq_MESCs_Mouse1.18633609
78CIITA_25753668_ChIP-Seq_RAJI_Human1.18600731
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18527924
80GABP_19822575_ChIP-Seq_HepG2_Human1.17786445
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.17762241
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17680626
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17583422
84MAF_26560356_Chip-Seq_TH2_Human1.17319523
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16420350
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16156955
87* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15852572
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15388008
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14984400
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14965225
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13780695
92MAF_26560356_Chip-Seq_TH1_Human1.13192835
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12564471
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12239067
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11919632
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11680533
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11481591
98E2F7_22180533_ChIP-Seq_HELA_Human1.11070782
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10548483
100SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10328028
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09955124
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09449483
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08474016
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06972221
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06909220
106SA1_27219007_Chip-Seq_Bcells_Human1.06601604
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06535147
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06363627
109* GATA1_19941827_ChIP-Seq_MEL_Mouse1.06187623
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.06055428
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.05369276
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04858055
113PHF8_20622854_ChIP-Seq_HELA_Human1.04693435
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.04480284
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04337499
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04134735
117IRF8_22096565_ChIP-ChIP_GC-B_Human1.03868844
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03516219
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02943014
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.02505478
121KDM5A_27292631_Chip-Seq_BREAST_Human1.02377780
122* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02224863
123THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01521992
124* CTCF_21964334_Chip-Seq_Bcells_Human1.01236451
125UTX_26944678_Chip-Seq_JUKART_Human1.01163231
126VDR_23849224_ChIP-Seq_CD4+_Human1.01155338
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01069843
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00796961
129* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00513515
130GATA6_25053715_ChIP-Seq_YYC3_Human1.00496042
131FOXP3_21729870_ChIP-Seq_TREG_Human1.00225031
132* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00172014
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99953773
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99854664
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98635103
136ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98377585
137TCF7_22412390_ChIP-Seq_EML_Mouse0.96194849
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.95833801
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.95352563
140* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94872027
141E2F1_20622854_ChIP-Seq_HELA_Human0.94706727
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92635131
143POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92601289
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92576179
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.92348948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.84002618
2MP0002139_abnormal_hepatobiliary_system4.73342389
3MP0009840_abnormal_foam_cell3.78531403
4MP0005085_abnormal_gallbladder_physiolo3.71594841
5MP0003806_abnormal_nucleotide_metabolis3.54790276
6MP0005365_abnormal_bile_salt3.43095261
7MP0005083_abnormal_biliary_tract3.14560899
8MP0008875_abnormal_xenobiotic_pharmacok3.00018004
9MP0003303_peritoneal_inflammation2.80199888
10MP0009278_abnormal_bone_marrow2.54665686
11MP0002837_dystrophic_cardiac_calcinosis2.46265065
12MP0001666_abnormal_nutrient_absorption2.45788331
13MP0003656_abnormal_erythrocyte_physiolo2.45021384
14MP0003646_muscle_fatigue2.35463025
15MP0003191_abnormal_cellular_cholesterol2.32297586
16MP0005332_abnormal_amino_acid2.28044555
17MP0006036_abnormal_mitochondrial_physio2.25747841
18MP0010329_abnormal_lipoprotein_level2.14860166
19MP0008260_abnormal_autophagy2.07401594
20MP0005451_abnormal_body_composition2.07088428
21MP0003252_abnormal_bile_duct2.03992697
22MP0003195_calcinosis1.95291201
23MP0003172_abnormal_lysosome_physiology1.85788434
24MP0003453_abnormal_keratinocyte_physiol1.83764256
25MP0009643_abnormal_urine_homeostasis1.83267597
26MP0000609_abnormal_liver_physiology1.78114309
27MP0004019_abnormal_vitamin_homeostasis1.77448288
28MP0000678_abnormal_parathyroid_gland1.75097555
29MP0004510_myositis1.74946905
30MP0005319_abnormal_enzyme/_coenzyme1.73542939
31MP0005397_hematopoietic_system_phenotyp1.57039740
32MP0001545_abnormal_hematopoietic_system1.57039740
33MP0000749_muscle_degeneration1.56712950
34MP0002118_abnormal_lipid_homeostasis1.53952396
35MP0005636_abnormal_mineral_homeostasis1.53495644
36MP0004147_increased_porphyrin_level1.53169732
37MP0001764_abnormal_homeostasis1.52380614
38MP0004233_abnormal_muscle_weight1.51737764
39MP0005330_cardiomyopathy1.51202492
40MP0002138_abnormal_hepatobiliary_system1.50855802
41MP0005076_abnormal_cell_differentiation1.49383282
42MP0003693_abnormal_embryo_hatching1.48698839
43MP0005464_abnormal_platelet_physiology1.46481668
44MP0006035_abnormal_mitochondrial_morpho1.45225504
45MP0004084_abnormal_cardiac_muscle1.44252017
46MP0005000_abnormal_immune_tolerance1.43938835
47MP0005670_abnormal_white_adipose1.43036776
48MP0002398_abnormal_bone_marrow1.39372482
49MP0002396_abnormal_hematopoietic_system1.39320396
50MP0004858_abnormal_nervous_system1.37268524
51MP0002419_abnormal_innate_immunity1.35524258
52MP0002132_abnormal_respiratory_system1.34894307
53MP0005387_immune_system_phenotype1.34743010
54MP0001790_abnormal_immune_system1.34743010
55MP0004043_abnormal_pH_regulation1.33937510
56MP0001849_ear_inflammation1.31614795
57MP0001819_abnormal_immune_cell1.31614376
58MP0002420_abnormal_adaptive_immunity1.31134148
59MP0005584_abnormal_enzyme/coenzyme_acti1.30733107
60MP0000759_abnormal_skeletal_muscle1.29600765
61MP0002269_muscular_atrophy1.26508975
62MP0010234_abnormal_vibrissa_follicle1.26048988
63MP0004130_abnormal_muscle_cell1.25978424
64MP0005666_abnormal_adipose_tissue1.25578732
65MP0004185_abnormal_adipocyte_glucose1.25432341
66MP0002723_abnormal_immune_serum1.24757656
67MP0004036_abnormal_muscle_relaxation1.24569315
68MP0004215_abnormal_myocardial_fiber1.24081398
69MP0003186_abnormal_redox_activity1.23497879
70MP0000703_abnormal_thymus_morphology1.22653697
71MP0000858_altered_metastatic_potential1.20298247
72MP0001800_abnormal_humoral_immune1.18867431
73MP0009379_abnormal_foot_pigmentation1.17398081
74MP0000747_muscle_weakness1.17124342
75MP0001835_abnormal_antigen_presentation1.16537636
76MP0002148_abnormal_hypersensitivity_rea1.15409910
77MP0002429_abnormal_blood_cell1.15298798
78MP0002452_abnormal_antigen_presenting1.15150180
79MP0000716_abnormal_immune_system1.14347419
80MP0001756_abnormal_urination1.14031240
81MP0003866_abnormal_defecation1.11963106
82MP0003705_abnormal_hypodermis_morpholog1.08534711
83MP0008961_abnormal_basal_metabolism1.07729343
84MP0002877_abnormal_melanocyte_morpholog1.07458478
85MP0000598_abnormal_liver_morphology1.07011121
86MP0000689_abnormal_spleen_morphology1.05160432
87MP0004145_abnormal_muscle_electrophysio1.05134436
88MP0000751_myopathy1.04876406
89MP0004808_abnormal_hematopoietic_stem1.04091971
90MP0004087_abnormal_muscle_fiber1.02637766
91MP0002106_abnormal_muscle_physiology1.01142403
92MP0002078_abnormal_glucose_homeostasis1.00573907
93MP0005266_abnormal_metabolism1.00016058
94MP0008469_abnormal_protein_level0.98523436
95MP0000750_abnormal_muscle_regeneration0.98004784
96MP0002405_respiratory_system_inflammati0.96971259
97MP0009931_abnormal_skin_appearance0.96059889
98MP0003724_increased_susceptibility_to0.95124319
99MP0005310_abnormal_salivary_gland0.94862054
100MP0002254_reproductive_system_inflammat0.94748513
101MP0003011_delayed_dark_adaptation0.93374636
102MP0001765_abnormal_ion_homeostasis0.93062517
103MP0001533_abnormal_skeleton_physiology0.91954555
104MP0003111_abnormal_nucleus_morphology0.91872115
105MP0001873_stomach_inflammation0.90481778
106MP0000313_abnormal_cell_death0.90432274
107MP0002796_impaired_skin_barrier0.90416836
108MP0000685_abnormal_immune_system0.89443973
109MP0003300_gastrointestinal_ulcer0.88954236
110MP0000015_abnormal_ear_pigmentation0.88295452
111MP0003221_abnormal_cardiomyocyte_apopto0.88174090
112MP0010155_abnormal_intestine_physiology0.87306977
113MP0004957_abnormal_blastocyst_morpholog0.86891663
114MP0000490_abnormal_crypts_of0.86778330
115MP0005166_decreased_susceptibility_to0.85741799
116MP0009333_abnormal_splenocyte_physiolog0.85605978
117MP0000003_abnormal_adipose_tissue0.85382698
118MP0004381_abnormal_hair_follicle0.85375327
119MP0009642_abnormal_blood_homeostasis0.84953208
120MP0003878_abnormal_ear_physiology0.84778660
121MP0005377_hearing/vestibular/ear_phenot0.84778660
122MP0000733_abnormal_muscle_development0.84659093
123MP0005671_abnormal_response_to0.83708157
124MP0003763_abnormal_thymus_physiology0.83028766
125MP0005058_abnormal_lysosome_morphology0.82440403
126MP0002971_abnormal_brown_adipose0.81839615
127MP0002136_abnormal_kidney_physiology0.80794032
128MP0005375_adipose_tissue_phenotype0.80136084
129MP0003436_decreased_susceptibility_to0.77383696
130MP0003868_abnormal_feces_composition0.77027872
131MP0010630_abnormal_cardiac_muscle0.76490102
132MP0004947_skin_inflammation0.75967926
133MP0004264_abnormal_extraembryonic_tissu0.75374264
134MP0000358_abnormal_cell_content/0.75361849
135MP0005501_abnormal_skin_physiology0.74344002
136MP0002822_catalepsy0.74105959
137MP0008775_abnormal_heart_ventricle0.73114925
138MP0001544_abnormal_cardiovascular_syste0.72845742
139MP0005385_cardiovascular_system_phenoty0.72845742
140MP0009763_increased_sensitivity_to0.71834520
141MP0001663_abnormal_digestive_system0.71470903
142MP0005025_abnormal_response_to0.69624486
143MP0005376_homeostasis/metabolism_phenot0.68518594
144MP0003137_abnormal_impulse_conducting0.68076790
145MP0002332_abnormal_exercise_endurance0.67142177
146MP0000477_abnormal_intestine_morphology0.66200016
147MP0001845_abnormal_inflammatory_respons0.64590895
148MP0009785_altered_susceptibility_to0.63938266
149MP0002722_abnormal_immune_system0.63299463
150MP0005334_abnormal_fat_pad0.62193629
151MP0002972_abnormal_cardiac_muscle0.61975179

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22956041
2Hypoglycemic coma (HP:0001325)3.95569494
3Xanthomatosis (HP:0000991)3.83182840
4Muscle fiber inclusion bodies (HP:0100299)3.81466243
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.69266753
6Myoglobinuria (HP:0002913)3.66289523
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.65385804
8Nemaline bodies (HP:0003798)3.63312749
9Hyperammonemia (HP:0001987)3.63026629
10Centrally nucleated skeletal muscle fibers (HP:0003687)3.62826623
11Hyperglycinuria (HP:0003108)3.62056878
12Abnormality of fatty-acid metabolism (HP:0004359)3.55077791
13Eczematoid dermatitis (HP:0000976)3.54505361
14Ketosis (HP:0001946)3.48179202
15Gout (HP:0001997)3.45971349
16Dicarboxylic aciduria (HP:0003215)3.43826606
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.43826606
18Rhabdomyolysis (HP:0003201)3.35467451
19Hyperglycinemia (HP:0002154)3.33386292
20Intrahepatic cholestasis (HP:0001406)3.32423601
21Hepatic necrosis (HP:0002605)3.24123362
22Abnormality of serine family amino acid metabolism (HP:0010894)3.19434208
23Abnormality of glycine metabolism (HP:0010895)3.19434208
24Hyperlipoproteinemia (HP:0010980)3.11781439
25Late onset (HP:0003584)3.07718373
26Distal lower limb muscle weakness (HP:0009053)3.04862494
27Malnutrition (HP:0004395)3.00882493
28Deep venous thrombosis (HP:0002625)2.99678782
29Ketoacidosis (HP:0001993)2.97372276
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91590099
31Hypobetalipoproteinemia (HP:0003563)2.90744105
32Generalized aminoaciduria (HP:0002909)2.86026280
33Increased connective tissue (HP:0009025)2.82338831
34Hypoalphalipoproteinemia (HP:0003233)2.82302684
35Increased IgE level (HP:0003212)2.79624377
36Poikilocytosis (HP:0004447)2.79199125
37Hyperbilirubinemia (HP:0002904)2.78438266
38Increased muscle lipid content (HP:0009058)2.77541331
39Ileus (HP:0002595)2.75698633
40Hypolipoproteinemia (HP:0010981)2.75095469
41Ventricular tachycardia (HP:0004756)2.72425748
42Lethargy (HP:0001254)2.70263220
43Bulbar palsy (HP:0001283)2.69907358
44Nausea (HP:0002018)2.66929598
45Metabolic acidosis (HP:0001942)2.66794056
46Type 1 muscle fiber predominance (HP:0003803)2.66504380
47Sudden death (HP:0001699)2.65865528
48Right ventricular cardiomyopathy (HP:0011663)2.60769346
49Cerebral edema (HP:0002181)2.60432465
50Hepatocellular necrosis (HP:0001404)2.60416098
51Reticulocytosis (HP:0001923)2.60277206
52Exercise-induced myalgia (HP:0003738)2.59032576
53Petechiae (HP:0000967)2.57859595
54Hypertensive crisis (HP:0100735)2.55626914
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54813815
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54813815
57Cholelithiasis (HP:0001081)2.52251958
58Ragged-red muscle fibers (HP:0003200)2.51915403
59Progressive muscle weakness (HP:0003323)2.49124673
60Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.47876402
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.47297389
62EMG: myopathic abnormalities (HP:0003458)2.46709899
63Abnormal gallbladder physiology (HP:0012438)2.44367302
64Cholecystitis (HP:0001082)2.44367302
65Abnormality of purine metabolism (HP:0004352)2.43503120
66Distal lower limb amyotrophy (HP:0008944)2.43012134
67Abnormality of skeletal muscle fiber size (HP:0012084)2.41899091
68Palpitations (HP:0001962)2.40037348
69Ventricular fibrillation (HP:0001663)2.38803499
70Increased intramyocellular lipid droplets (HP:0012240)2.36804332
71Diaphragmatic weakness (HP:0009113)2.36297213
72Abnormality of cells of the erythroid lineage (HP:0012130)2.34547791
73Muscle hypertrophy of the lower extremities (HP:0008968)2.34115619
74Colitis (HP:0002583)2.34097058
75Multiple enchondromatosis (HP:0005701)2.33647064
76Abnormal gallbladder morphology (HP:0012437)2.33118355
77Abnormality of nucleobase metabolism (HP:0010932)2.32525619
78Polycythemia (HP:0001901)2.32376333
79Vomiting (HP:0002013)2.32252606
80Muscle fiber splitting (HP:0003555)2.31943086
81Ulnar deviation of the wrist (HP:0003049)2.31716740
82Exercise-induced muscle cramps (HP:0003710)2.31397356
83Abnormality of macrophages (HP:0004311)2.31186173
84Abnormality of serum amino acid levels (HP:0003112)2.30970227
85Hyperuricemia (HP:0002149)2.29738018
86Increased purine levels (HP:0004368)2.29738018
87Recurrent abscess formation (HP:0002722)2.29143181
88Lactic acidosis (HP:0003128)2.28735545
89Hyperinsulinemic hypoglycemia (HP:0000825)2.28464571
90Gastrointestinal inflammation (HP:0004386)2.27599857
91Cellulitis (HP:0100658)2.27486157
92Difficulty climbing stairs (HP:0003551)2.27023983
93Prolonged partial thromboplastin time (HP:0003645)2.26934345
94Abnormality of urine glucose concentration (HP:0011016)2.26451156
95Glycosuria (HP:0003076)2.26451156
96Obstructive lung disease (HP:0006536)2.25235574
97Chronic obstructive pulmonary disease (HP:0006510)2.25235574
98Proximal tubulopathy (HP:0000114)2.24202744
99Abnormality of the thoracic spine (HP:0100711)2.24075064
100Acute encephalopathy (HP:0006846)2.23094278
101Abnormal number of erythroid precursors (HP:0012131)2.21761574
102Increased serum ferritin (HP:0003281)2.21723621
103Recurrent bacterial skin infections (HP:0005406)2.21448445
104Abnormality of sulfur amino acid metabolism (HP:0004339)2.21367922
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20965214
106Easy fatigability (HP:0003388)2.20771590
107Abnormality of reticulocytes (HP:0004312)2.17555073
108Acanthocytosis (HP:0001927)2.16877129
109Lipid accumulation in hepatocytes (HP:0006561)2.16238438
110Increased variability in muscle fiber diameter (HP:0003557)2.15007573
111Abnormality of the heme biosynthetic pathway (HP:0010472)2.14703022
112Increased serum lactate (HP:0002151)2.14049116
113Abnormality of the Achilles tendon (HP:0005109)2.10640853
114Abnormality of pyrimidine metabolism (HP:0004353)2.10570616
115Myopathic facies (HP:0002058)2.09351322
116Abnormality of transition element cation homeostasis (HP:0011030)2.08708754
117Calf muscle hypertrophy (HP:0008981)2.08232422
118Hyporeflexia of lower limbs (HP:0002600)2.07228726
119Abnormality of iron homeostasis (HP:0011031)2.06373911
120Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05087049
121Testicular atrophy (HP:0000029)2.04823405
122Recurrent viral infections (HP:0004429)2.04029178
123Obstructive sleep apnea (HP:0002870)2.03454242
124Recurrent fungal infections (HP:0002841)2.03219774
125Abnormal mitochondria in muscle tissue (HP:0008316)2.01830436
126Inflammation of the large intestine (HP:0002037)2.00937792
127Stomatitis (HP:0010280)2.00263222
128Increased CSF lactate (HP:0002490)1.99586057
129Mitochondrial inheritance (HP:0001427)1.98953936
130Thin bony cortex (HP:0002753)1.98031931
131Stridor (HP:0010307)1.97585821
132Progressive external ophthalmoplegia (HP:0000590)1.95950223
133Hyperactive renin-angiotensin system (HP:0000841)1.93404372
134EMG: neuropathic changes (HP:0003445)1.92748827
135Increased cerebral lipofuscin (HP:0011813)1.92463830
136Segmental peripheral demyelination/remyelination (HP:0003481)1.92141291
137Paralysis (HP:0003470)1.91549094
138Truncus arteriosus (HP:0001660)1.91337778
139Asymmetric septal hypertrophy (HP:0001670)1.90767281
140Macrocytic anemia (HP:0001972)1.90674312
141Hyperparathyroidism (HP:0000843)1.90080701
142Brushfield spots (HP:0001088)1.89867485
143Abnormality of the intrinsic pathway (HP:0010989)1.89637441
144Muscle stiffness (HP:0003552)1.89329519
145Thoracic kyphosis (HP:0002942)1.89094094
146Acute necrotizing encephalopathy (HP:0006965)1.89035120
147Pustule (HP:0200039)1.88983136
148Syncope (HP:0001279)1.88644040
149Hemorrhage of the eye (HP:0011885)1.87261244
150Abnormality of the fingertips (HP:0001211)1.87185619
151CNS demyelination (HP:0007305)1.86801246
152Achilles tendon contracture (HP:0001771)1.85570972
153Neck muscle weakness (HP:0000467)1.84728305
154Seborrheic dermatitis (HP:0001051)1.84452622
155Hypochromic anemia (HP:0001931)1.83993483
156Fatigue (HP:0012378)1.82863259
157Gastrointestinal dysmotility (HP:0002579)1.79660245
158Abnormality of the gallbladder (HP:0005264)1.79255289
159External ophthalmoplegia (HP:0000544)1.79117907
160Prolonged bleeding time (HP:0003010)1.78695310
161Bowel incontinence (HP:0002607)1.78685352
162Gastrointestinal infarctions (HP:0005244)1.78236289
163Subaortic stenosis (HP:0001682)1.78115945
164Abnormality of the left ventricular outflow tract (HP:0011103)1.78115945
165Round ear (HP:0100830)1.77133325
166Axonal loss (HP:0003447)1.76119634
167Abnormal large intestine physiology (HP:0012700)1.76076987
168Hyperacusis (HP:0010780)1.75557222
169Difficulty running (HP:0009046)1.73045753
170Ulnar bowing (HP:0003031)1.72295540
171Increased neuronal autofluorescent lipopigment (HP:0002074)1.71624242
172Generalized muscle weakness (HP:0003324)1.70725513

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.35351771
2BCKDK4.06714290
3PRPF4B3.61165627
4PKN23.37859212
5SMG12.96539473
6NME22.94823481
7ERN12.92925645
8TLK12.91593263
9MST1R2.81490566
10MAP3K102.26292410
11MAP3K112.17103683
12MAP4K11.94524064
13MAP2K21.83266335
14TESK21.78071486
15GRK61.75307902
16NME11.74804686
17FGFR41.66572829
18TTN1.60576381
19TYK21.59768713
20LMTK21.59113345
21EIF2AK11.56668959
22EPHA21.55728970
23NEK11.53765430
24KDR1.53690374
25FLT31.52299178
26MAP2K31.52095202
27RIPK41.51389518
28IRAK41.47329152
29NEK21.44708463
30PDK31.42469758
31PDK41.42469758
32PRKD21.32075700
33MAPK111.30622783
34PIK3CA1.26528282
35CDK121.26487592
36BUB11.23421935
37STK161.14298844
38TBK11.14014510
39ARAF1.12418944
40SIK31.10806225
41IRAK21.09906179
42HIPK21.09061623
43PTK61.09029025
44MAPKAPK31.07216908
45SCYL21.06644789
46STK101.05375705
47CDK191.05356030
48ZAP701.05181159
49OBSCN1.03768738
50TNK21.02977518
51CDK41.02286917
52TTK1.01496004
53EEF2K1.00018467
54RPS6KL10.99272508
55RPS6KC10.99272508
56MAP3K130.98266385
57MAPK120.98170322
58MAP3K140.95345661
59LRRK20.95087607
60RPS6KB20.94571487
61TAOK10.93072252
62STK40.92638448
63MAP2K60.89874614
64MARK20.89758891
65MAP3K30.89146752
66MAP3K80.88382081
67DAPK30.88236089
68IRAK30.87629081
69BMX0.85606979
70PIM20.84020243
71PHKG10.83394313
72PHKG20.83394313
73MAP3K70.83210449
74SIK10.83019490
75WNK40.82336404
76RPS6KA20.79743219
77TESK10.78317667
78RPS6KA60.77085537
79PRKG20.76462450
80MYLK0.76110317
81MAP3K10.75930976
82IKBKB0.74233297
83PIK3CG0.73285715
84VRK20.70148003
85MET0.69469926
86JAK20.66820026
87BTK0.65878510
88EIF2AK30.65779135
89IKBKE0.65099524
90WEE10.63991754
91BLK0.63126251
92KSR20.61607600
93AURKA0.60746653
94JAK30.60280612
95STK380.60160912
96TAOK30.58413359
97ILK0.57978653
98PAK40.56625012
99ABL20.56276473
100SIK20.55715047
101CDC42BPA0.55168752
102DYRK1B0.54453763
103HCK0.54400196
104AURKB0.54391499
105PRKAA10.54349104
106PRKCI0.52354879
107CDK70.51036153
108RPS6KA40.50251732
109MAP2K10.49056344
110JAK10.48660041
111DYRK30.48404414
112MAP3K50.48160298
113STK240.47383911
114NEK90.46753344
115CSK0.44903140
116MAPK70.44599725
117RPS6KA10.44585890
118AKT20.44057278
119STK38L0.43890579
120EPHB10.43883474
121MAPK150.43792128
122MAP3K60.43425699
123MARK30.43004167
124PTK20.41763591
125PRKD30.40843182
126MUSK0.40510383
127PLK10.40180587
128BRAF0.39181334
129PDK20.39066287
130MATK0.38888526
131PIM10.38285211
132TXK0.38206097
133PDPK10.38106439
134PRKAA20.36391744
135TAOK20.36017288
136RIPK10.34686132
137MTOR0.34435961
138ICK0.34158056
139MAPKAPK20.33730432
140PDK10.33452380
141SYK0.32352410

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.94175675
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86927293
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81449515
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.75526647
5Fatty acid degradation_Homo sapiens_hsa000712.72687462
6Sulfur relay system_Homo sapiens_hsa041222.71861298
7Acute myeloid leukemia_Homo sapiens_hsa052212.48181625
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37378212
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.23695965
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23114876
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22023539
12Arginine biosynthesis_Homo sapiens_hsa002202.20896515
13Propanoate metabolism_Homo sapiens_hsa006402.20669454
14Tryptophan metabolism_Homo sapiens_hsa003802.14897248
15Folate biosynthesis_Homo sapiens_hsa007902.10608309
16Carbon metabolism_Homo sapiens_hsa012002.10373463
17Ribosome_Homo sapiens_hsa030101.98041584
18B cell receptor signaling pathway_Homo sapiens_hsa046621.87672588
19Fat digestion and absorption_Homo sapiens_hsa049751.87417260
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.85784489
21Chronic myeloid leukemia_Homo sapiens_hsa052201.81550297
22Pyruvate metabolism_Homo sapiens_hsa006201.80251137
23Biosynthesis of amino acids_Homo sapiens_hsa012301.71581319
24Nitrogen metabolism_Homo sapiens_hsa009101.68776153
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67734778
26Non-small cell lung cancer_Homo sapiens_hsa052231.65554362
27Selenocompound metabolism_Homo sapiens_hsa004501.63428728
28VEGF signaling pathway_Homo sapiens_hsa043701.63223844
29Osteoclast differentiation_Homo sapiens_hsa043801.60664665
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59520939
31Notch signaling pathway_Homo sapiens_hsa043301.57058684
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.56977809
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.55873719
34Butanoate metabolism_Homo sapiens_hsa006501.55290396
35Fatty acid metabolism_Homo sapiens_hsa012121.54676748
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.54542956
37Fructose and mannose metabolism_Homo sapiens_hsa000511.49975074
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49068452
39Peroxisome_Homo sapiens_hsa041461.46593824
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.46037835
41Sulfur metabolism_Homo sapiens_hsa009201.45820508
42beta-Alanine metabolism_Homo sapiens_hsa004101.44261238
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43163271
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42109323
45Parkinsons disease_Homo sapiens_hsa050121.41906158
46PPAR signaling pathway_Homo sapiens_hsa033201.41656879
47Oxidative phosphorylation_Homo sapiens_hsa001901.38709484
48Pentose phosphate pathway_Homo sapiens_hsa000301.38324245
49Leishmaniasis_Homo sapiens_hsa051401.32134217
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31441717
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.28299406
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27627909
53Hepatitis C_Homo sapiens_hsa051601.26491435
54Caffeine metabolism_Homo sapiens_hsa002321.26240242
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24304478
56Pancreatic cancer_Homo sapiens_hsa052121.22758952
57Phenylalanine metabolism_Homo sapiens_hsa003601.21425556
58Apoptosis_Homo sapiens_hsa042101.20499022
59Vitamin B6 metabolism_Homo sapiens_hsa007501.20372842
60Bile secretion_Homo sapiens_hsa049761.17466692
61Galactose metabolism_Homo sapiens_hsa000521.16958325
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14315385
63Hepatitis B_Homo sapiens_hsa051611.13804359
64Histidine metabolism_Homo sapiens_hsa003401.13742683
65Starch and sucrose metabolism_Homo sapiens_hsa005001.13593796
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12225769
67One carbon pool by folate_Homo sapiens_hsa006701.12188555
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12054859
69Herpes simplex infection_Homo sapiens_hsa051681.11825458
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11219131
71Complement and coagulation cascades_Homo sapiens_hsa046101.07784368
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07500522
73T cell receptor signaling pathway_Homo sapiens_hsa046601.06491507
74TNF signaling pathway_Homo sapiens_hsa046681.04529628
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03905869
76Arginine and proline metabolism_Homo sapiens_hsa003301.02557828
77Neurotrophin signaling pathway_Homo sapiens_hsa047221.00382011
78ABC transporters_Homo sapiens_hsa020100.98957905
79Tuberculosis_Homo sapiens_hsa051520.98221102
80Cardiac muscle contraction_Homo sapiens_hsa042600.97648823
81Chemical carcinogenesis_Homo sapiens_hsa052040.96029262
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95855552
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94630899
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92710845
85Influenza A_Homo sapiens_hsa051640.91923782
86Glycerolipid metabolism_Homo sapiens_hsa005610.90942490
87Glutathione metabolism_Homo sapiens_hsa004800.88300122
88Viral carcinogenesis_Homo sapiens_hsa052030.87482938
89Toxoplasmosis_Homo sapiens_hsa051450.87202424
90Thyroid cancer_Homo sapiens_hsa052160.86538054
91Alzheimers disease_Homo sapiens_hsa050100.85272573
92HTLV-I infection_Homo sapiens_hsa051660.85120687
93Endometrial cancer_Homo sapiens_hsa052130.84788908
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84693109
95Huntingtons disease_Homo sapiens_hsa050160.84447184
96Salmonella infection_Homo sapiens_hsa051320.84396633
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84268868
98Shigellosis_Homo sapiens_hsa051310.82770283
99GnRH signaling pathway_Homo sapiens_hsa049120.81160484
100Retinol metabolism_Homo sapiens_hsa008300.80172870
101Epstein-Barr virus infection_Homo sapiens_hsa051690.79786120
102Prion diseases_Homo sapiens_hsa050200.79138281
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79029037
104mTOR signaling pathway_Homo sapiens_hsa041500.77924882
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.77822047
106Measles_Homo sapiens_hsa051620.76026362
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75630798
108Renal cell carcinoma_Homo sapiens_hsa052110.75265264
109Pyrimidine metabolism_Homo sapiens_hsa002400.73902491
110Vitamin digestion and absorption_Homo sapiens_hsa049770.73467256
111Metabolic pathways_Homo sapiens_hsa011000.72604230
112Staphylococcus aureus infection_Homo sapiens_hsa051500.71765182
113Lysosome_Homo sapiens_hsa041420.70994168
114Legionellosis_Homo sapiens_hsa051340.70151899
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69619838
116Proteasome_Homo sapiens_hsa030500.69363380
117Tyrosine metabolism_Homo sapiens_hsa003500.68324071
118Lysine degradation_Homo sapiens_hsa003100.68262530
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67046595
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64391323
121Inositol phosphate metabolism_Homo sapiens_hsa005620.64258638
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64060274
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61490568
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61432738
125Malaria_Homo sapiens_hsa051440.61355070
126Endocytosis_Homo sapiens_hsa041440.59985966
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.58974295
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.58845746
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58488525
130Viral myocarditis_Homo sapiens_hsa054160.57659400
131Fatty acid elongation_Homo sapiens_hsa000620.57168634
132Chemokine signaling pathway_Homo sapiens_hsa040620.57144218
133Prolactin signaling pathway_Homo sapiens_hsa049170.56873524
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56231336
135Insulin resistance_Homo sapiens_hsa049310.55810137
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.55678099
137Glioma_Homo sapiens_hsa052140.55208490
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55099755
139ErbB signaling pathway_Homo sapiens_hsa040120.50840690
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.50638228
141Hematopoietic cell lineage_Homo sapiens_hsa046400.50459453
142Prostate cancer_Homo sapiens_hsa052150.49073905
143DNA replication_Homo sapiens_hsa030300.48112121
144HIF-1 signaling pathway_Homo sapiens_hsa040660.46379297
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45036633
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43420707
147Mineral absorption_Homo sapiens_hsa049780.43385913
148Small cell lung cancer_Homo sapiens_hsa052220.39271945
149FoxO signaling pathway_Homo sapiens_hsa040680.39218879
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.37885126
151RNA polymerase_Homo sapiens_hsa030200.37589004
152Linoleic acid metabolism_Homo sapiens_hsa005910.37518003
153AMPK signaling pathway_Homo sapiens_hsa041520.32696673
154Protein export_Homo sapiens_hsa030600.32172560
155Systemic lupus erythematosus_Homo sapiens_hsa053220.31151277
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30544630
157Other glycan degradation_Homo sapiens_hsa005110.28147401
158Glucagon signaling pathway_Homo sapiens_hsa049220.27191286
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.26915605
160Bladder cancer_Homo sapiens_hsa052190.25106995
161Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24888219
162Base excision repair_Homo sapiens_hsa034100.24784840
163Primary immunodeficiency_Homo sapiens_hsa053400.23974074
164Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23126846
165Mismatch repair_Homo sapiens_hsa034300.22934653
166Insulin signaling pathway_Homo sapiens_hsa049100.22893486

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »