ATG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.75523992
2L-phenylalanine catabolic process (GO:0006559)4.75523992
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59311664
4L-phenylalanine metabolic process (GO:0006558)4.59311664
5aromatic amino acid family catabolic process (GO:0009074)4.53603912
6ribosome assembly (GO:0042255)4.48037400
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.41705666
8aldehyde catabolic process (GO:0046185)4.41078835
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.40797156
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.32376475
11tryptophan catabolic process (GO:0006569)4.27439047
12indole-containing compound catabolic process (GO:0042436)4.27439047
13indolalkylamine catabolic process (GO:0046218)4.27439047
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.24843766
15negative regulation of ligase activity (GO:0051352)4.05295541
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.05295541
17tryptophan metabolic process (GO:0006568)4.03328002
18regulation of meiosis I (GO:0060631)4.01570727
19urea metabolic process (GO:0019627)4.01477295
20urea cycle (GO:0000050)4.01477295
21cysteine metabolic process (GO:0006534)3.90105796
22DNA double-strand break processing (GO:0000729)3.88772121
23bile acid biosynthetic process (GO:0006699)3.86728225
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.83902395
25regulation of helicase activity (GO:0051095)3.83315756
26kynurenine metabolic process (GO:0070189)3.81293583
27regulation of cellular amino acid metabolic process (GO:0006521)3.79022843
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.78493234
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.73717974
30cullin deneddylation (GO:0010388)3.72038855
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.72005180
32establishment of integrated proviral latency (GO:0075713)3.70480412
33nitrogen cycle metabolic process (GO:0071941)3.66774354
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.64918593
35regulation of mitotic spindle checkpoint (GO:1903504)3.64918593
36positive regulation of ligase activity (GO:0051351)3.64558378
37DNA replication checkpoint (GO:0000076)3.64553859
38transcription from mitochondrial promoter (GO:0006390)3.63916892
39histone exchange (GO:0043486)3.62235641
40glyoxylate metabolic process (GO:0046487)3.60319549
41DNA damage response, detection of DNA damage (GO:0042769)3.58151658
42peptidyl-glutamic acid carboxylation (GO:0017187)3.56562053
43protein carboxylation (GO:0018214)3.56562053
44histone mRNA metabolic process (GO:0008334)3.54898437
45rRNA modification (GO:0000154)3.54017106
46regulation of ubiquitin-protein transferase activity (GO:0051438)3.52544062
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.48807969
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.48807969
49signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.48807969
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.47136385
51serine family amino acid catabolic process (GO:0009071)3.47130570
52sulfur amino acid catabolic process (GO:0000098)3.44148990
53mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43797935
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.42745180
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.42745180
56regulation of ligase activity (GO:0051340)3.41905501
57DNA catabolic process, exonucleolytic (GO:0000738)3.41287987
58glycine metabolic process (GO:0006544)3.39288571
59protein targeting to mitochondrion (GO:0006626)3.39032160
60signal transduction involved in DNA damage checkpoint (GO:0072422)3.38073438
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38073438
62aromatic amino acid family metabolic process (GO:0009072)3.37922608
63regulation of mitochondrial translation (GO:0070129)3.37678510
64high-density lipoprotein particle remodeling (GO:0034375)3.36978698
65spindle checkpoint (GO:0031577)3.36652990
66negative regulation of fibrinolysis (GO:0051918)3.36009995
67mitotic spindle checkpoint (GO:0071174)3.34327247
68signal transduction involved in cell cycle checkpoint (GO:0072395)3.34110318
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.30196819
70negative regulation of sister chromatid segregation (GO:0033046)3.30196819
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30196819
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.30196819
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30196819
74regulation of cholesterol esterification (GO:0010872)3.28743269
75DNA replication-independent nucleosome organization (GO:0034724)3.27315061
76DNA replication-independent nucleosome assembly (GO:0006336)3.27315061
77synapsis (GO:0007129)3.27062701
78mitochondrial RNA metabolic process (GO:0000959)3.26605145
79establishment of viral latency (GO:0019043)3.26355042
80negative regulation of chromosome segregation (GO:0051985)3.26289229
81rRNA methylation (GO:0031167)3.25052200
82cellular biogenic amine catabolic process (GO:0042402)3.24494503
83amine catabolic process (GO:0009310)3.24494503
84DNA strand elongation involved in DNA replication (GO:0006271)3.22231512
85mitotic metaphase plate congression (GO:0007080)3.21931146
86cellular ketone body metabolic process (GO:0046950)3.21350761
87nuclear pore complex assembly (GO:0051292)3.20340413
88bile acid metabolic process (GO:0008206)3.19080123
89S-adenosylmethionine metabolic process (GO:0046500)3.17800120
90formation of translation preinitiation complex (GO:0001731)3.17251888
91mitotic spindle assembly checkpoint (GO:0007094)3.16924679
92serine family amino acid biosynthetic process (GO:0009070)3.16717131
93maturation of 5.8S rRNA (GO:0000460)3.15627131
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14807805
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14807805
96telomere maintenance via semi-conservative replication (GO:0032201)3.14768874
97protein localization to mitochondrion (GO:0070585)3.14391118
98DNA strand elongation (GO:0022616)3.13782548
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13491112
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13491112
101protein localization to kinetochore (GO:0034501)3.13417257
102establishment of chromosome localization (GO:0051303)3.13344329
103regulation of fibrinolysis (GO:0051917)3.13328852
104spliceosomal snRNP assembly (GO:0000387)3.11858823
105spindle assembly checkpoint (GO:0071173)3.11688071
106serine family amino acid metabolic process (GO:0009069)3.11432250
107indolalkylamine metabolic process (GO:0006586)3.11360862
108cell cycle G1/S phase transition (GO:0044843)3.11033637
109G1/S transition of mitotic cell cycle (GO:0000082)3.11033637
110L-methionine salvage (GO:0071267)3.10885870
111L-methionine biosynthetic process (GO:0071265)3.10885870
112amino acid salvage (GO:0043102)3.10885870
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10730259
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10221027
115bile acid and bile salt transport (GO:0015721)3.10003933
116regulation of chromosome segregation (GO:0051983)3.09956050
117purine nucleobase biosynthetic process (GO:0009113)3.06955005
118regulation of protein activation cascade (GO:2000257)3.06510126
119oxidative phosphorylation (GO:0006119)3.06470196
120cellular glucuronidation (GO:0052695)3.06071925
121protein deneddylation (GO:0000338)3.06060864
122nuclear pore organization (GO:0006999)3.05995074
123plasma lipoprotein particle remodeling (GO:0034369)3.05139979
124protein-lipid complex remodeling (GO:0034368)3.05139979
125macromolecular complex remodeling (GO:0034367)3.05139979
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04884140
127organelle disassembly (GO:1903008)3.04246565
128pseudouridine synthesis (GO:0001522)3.03890775
129complement activation, alternative pathway (GO:0006957)3.03676705
130establishment of protein localization to mitochondrion (GO:0072655)3.03278182
131regulation of mitotic sister chromatid separation (GO:0010965)3.02190214
132regulation of mitotic sister chromatid segregation (GO:0033047)3.02190214
133regulation of sister chromatid segregation (GO:0033045)3.02190214
134* negative regulation of protein ubiquitination (GO:0031397)3.00800227
135arginine metabolic process (GO:0006525)2.99999373
136proteasome assembly (GO:0043248)2.99841319
137regulation of triglyceride catabolic process (GO:0010896)2.97558574
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.97132962
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97132962
140folic acid metabolic process (GO:0046655)2.96630125
141low-density lipoprotein particle remodeling (GO:0034374)2.96423800
142negative regulation of DNA recombination (GO:0045910)2.95915677
143negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.95762207
144tRNA aminoacylation for protein translation (GO:0006418)2.95731828
145ribosomal large subunit biogenesis (GO:0042273)2.94965420
146uronic acid metabolic process (GO:0006063)2.94007266
147glucuronate metabolic process (GO:0019585)2.94007266
148amino-acid betaine metabolic process (GO:0006577)2.91390978
149tyrosine metabolic process (GO:0006570)2.91180319
150cofactor catabolic process (GO:0051187)2.89879590
151one-carbon metabolic process (GO:0006730)2.89453048
152homocysteine metabolic process (GO:0050667)2.84760168
153alpha-amino acid catabolic process (GO:1901606)2.84284357
154attachment of spindle microtubules to kinetochore (GO:0008608)2.83912798
155regulation of complement activation (GO:0030449)2.83452938
156sulfur amino acid biosynthetic process (GO:0000097)2.81372997
157fibrinolysis (GO:0042730)2.80887072
158reverse cholesterol transport (GO:0043691)2.79488523
159CENP-A containing nucleosome assembly (GO:0034080)2.79053102
160benzene-containing compound metabolic process (GO:0042537)2.76767555
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76319897
162folic acid-containing compound biosynthetic process (GO:0009396)2.76168590
163killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.75371516
164disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.75371516
165acylglycerol homeostasis (GO:0055090)2.73234005
166triglyceride homeostasis (GO:0070328)2.73234005
167lysine catabolic process (GO:0006554)2.73098534
168lysine metabolic process (GO:0006553)2.73098534
169sulfur amino acid metabolic process (GO:0000096)2.71688675
170phospholipid efflux (GO:0033700)2.71215082
171L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71023971
172imidazole-containing compound metabolic process (GO:0052803)2.70727543
173ketone body metabolic process (GO:1902224)2.70204003
174alpha-linolenic acid metabolic process (GO:0036109)2.70039957
175coenzyme catabolic process (GO:0009109)2.69343619
176primary alcohol catabolic process (GO:0034310)2.69117581
177chromatin remodeling at centromere (GO:0031055)2.67087701
178complement activation, classical pathway (GO:0006958)2.67071142
179drug catabolic process (GO:0042737)2.66431933
180urate metabolic process (GO:0046415)2.66314388
181pteridine-containing compound biosynthetic process (GO:0042559)2.65882583
182response to misfolded protein (GO:0051788)2.63989547
183chaperone-mediated protein transport (GO:0072321)2.62465847
184regulation of glucokinase activity (GO:0033131)2.61165088
185regulation of hexokinase activity (GO:1903299)2.61165088
186pyridine nucleotide biosynthetic process (GO:0019363)2.59452364
187nicotinamide nucleotide biosynthetic process (GO:0019359)2.59452364
188cellular amino acid catabolic process (GO:0009063)2.57323615
189metaphase plate congression (GO:0051310)2.55484245
190complement activation (GO:0006956)2.52993126
191NAD biosynthetic process (GO:0009435)2.52480760
192cellular aldehyde metabolic process (GO:0006081)2.50743770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.38828292
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.12151055
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01176763
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.76350002
5E2F7_22180533_ChIP-Seq_HELA_Human3.68576693
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.43037202
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.38260559
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.36327721
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.19780445
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91023551
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.74072365
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.59493480
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.57706505
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.52196841
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46364986
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.28734110
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26359408
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26133148
19AR_21909140_ChIP-Seq_LNCAP_Human2.22986716
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.11607916
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09534081
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02028544
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00991172
24* SRF_21415370_ChIP-Seq_HL-1_Mouse1.99786682
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98414866
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96675161
27DCP1A_22483619_ChIP-Seq_HELA_Human1.94985900
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93072293
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90496792
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90223839
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89887546
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85953253
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84144697
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82775595
35* VDR_23849224_ChIP-Seq_CD4+_Human1.79542819
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.79528908
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78455926
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77459678
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75496481
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.74231928
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.72853091
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71976103
43* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.71283509
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68193013
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67497987
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66620022
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64880321
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64023945
49* GABP_19822575_ChIP-Seq_HepG2_Human1.62965846
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62771371
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61115552
52FOXP3_21729870_ChIP-Seq_TREG_Human1.56317197
53* ELK1_19687146_ChIP-ChIP_HELA_Human1.55149822
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48480799
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.42251895
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35391461
57* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34393542
58MYC_18940864_ChIP-ChIP_HL60_Human1.34354670
59ZNF274_21170338_ChIP-Seq_K562_Hela1.33819375
60EWS_26573619_Chip-Seq_HEK293_Human1.33394023
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30876617
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.25208447
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22541755
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22395214
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21796636
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20462789
67VDR_22108803_ChIP-Seq_LS180_Human1.19463335
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19135731
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19000009
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17622249
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17106947
72FUS_26573619_Chip-Seq_HEK293_Human1.15503587
73* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15481611
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11193444
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09289094
76HTT_18923047_ChIP-ChIP_STHdh_Human1.08814646
77* XRN2_22483619_ChIP-Seq_HELA_Human1.08669197
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.08461199
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08302917
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.05897956
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04911251
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00419970
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00167168
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98374762
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98316597
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97772072
87* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96677122
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.95562499
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94475318
90TTF2_22483619_ChIP-Seq_HELA_Human0.93895180
91* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93329672
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.93122145
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92776218
94* SPI1_23547873_ChIP-Seq_NB4_Human0.92697503
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91640979
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90255410
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89740564
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87764852
99IRF1_19129219_ChIP-ChIP_H3396_Human0.86812172
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86272139
101* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85389078
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85081904
103KDM5A_27292631_Chip-Seq_BREAST_Human0.84919858
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.82985940
105MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82983380
106* EZH2_27294783_Chip-Seq_NPCs_Mouse0.82481390
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81158759
108YY1_21170310_ChIP-Seq_MESCs_Mouse0.81148679
109IGF1R_20145208_ChIP-Seq_DFB_Human0.79507881
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79486747
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78492602
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77692923
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76783198
114ELF5_23300383_ChIP-Seq_T47D_Human0.76697452
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.76243159
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74948589
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74883706
118TP53_22573176_ChIP-Seq_HFKS_Human0.74338431
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74303230
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74148369
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73552059
122TAF15_26573619_Chip-Seq_HEK293_Human0.73483998
123* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72517815
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71904168
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71349527
126* TFEB_21752829_ChIP-Seq_HELA_Human0.71249462
127ERG_20517297_ChIP-Seq_VCAP_Human0.70711771
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70364020
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.69415253
130CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67475861
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.66274982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.24622208
2MP0005360_urolithiasis5.54950489
3MP0003806_abnormal_nucleotide_metabolis4.67751184
4MP0005085_abnormal_gallbladder_physiolo4.52076769
5MP0005365_abnormal_bile_salt4.15691669
6MP0008875_abnormal_xenobiotic_pharmacok3.51761453
7MP0003718_maternal_effect3.00994451
8MP0009840_abnormal_foam_cell2.97455645
9MP0005451_abnormal_body_composition2.83380684
10MP0003693_abnormal_embryo_hatching2.71226473
11MP0003941_abnormal_skin_development2.62632982
12MP0003186_abnormal_redox_activity2.43291877
13MP0000372_irregular_coat_pigmentation2.40452237
14MP0005083_abnormal_biliary_tract2.22470976
15MP0009697_abnormal_copulation2.22203197
16MP0002138_abnormal_hepatobiliary_system2.10166709
17MP0003252_abnormal_bile_duct2.07681396
18MP0003195_calcinosis2.04902028
19MP0003786_premature_aging2.03541147
20* MP0005332_abnormal_amino_acid2.00699706
21MP0010329_abnormal_lipoprotein_level1.99487514
22MP0010352_gastrointestinal_tract_polyps1.97984660
23MP0005408_hypopigmentation1.93672834
24MP0001764_abnormal_homeostasis1.91653192
25MP0000358_abnormal_cell_content/1.88597023
26MP0003890_abnormal_embryonic-extraembry1.88570003
27MP0004957_abnormal_blastocyst_morpholog1.84852111
28MP0001666_abnormal_nutrient_absorption1.77597674
29MP0000350_abnormal_cell_proliferation1.64982902
30MP0003656_abnormal_erythrocyte_physiolo1.64960454
31MP0003221_abnormal_cardiomyocyte_apopto1.62842098
32MP0000569_abnormal_digit_pigmentation1.60729930
33MP0003567_abnormal_fetal_cardiomyocyte1.60188831
34MP0003436_decreased_susceptibility_to1.58055269
35MP0000609_abnormal_liver_physiology1.57189452
36MP0001835_abnormal_antigen_presentation1.56002124
37MP0004147_increased_porphyrin_level1.55363068
38MP0002090_abnormal_vision1.52191578
39MP0010094_abnormal_chromosome_stability1.50537746
40MP0010234_abnormal_vibrissa_follicle1.48716531
41MP0001929_abnormal_gametogenesis1.47652899
42MP0001697_abnormal_embryo_size1.44757716
43MP0003950_abnormal_plasma_membrane1.44561548
44MP0003191_abnormal_cellular_cholesterol1.40847217
45MP0009785_altered_susceptibility_to1.40511784
46MP0005395_other_phenotype1.40016275
47MP0005319_abnormal_enzyme/_coenzyme1.34049541
48MP0009764_decreased_sensitivity_to1.31043036
49MP0004019_abnormal_vitamin_homeostasis1.30018851
50MP0010307_abnormal_tumor_latency1.29418407
51MP0006036_abnormal_mitochondrial_physio1.28347879
52MP0001672_abnormal_embryogenesis/_devel1.28251499
53MP0005380_embryogenesis_phenotype1.28251499
54MP0003111_abnormal_nucleus_morphology1.24504379
55MP0001529_abnormal_vocalization1.24340553
56MP0003077_abnormal_cell_cycle1.24005383
57MP0002080_prenatal_lethality1.22869579
58MP0001119_abnormal_female_reproductive1.21653669
59MP0003868_abnormal_feces_composition1.19451194
60MP0000313_abnormal_cell_death1.18810424
61MP0006082_CNS_inflammation1.18556835
62MP0006054_spinal_hemorrhage1.17785686
63MP0005084_abnormal_gallbladder_morpholo1.17056285
64MP0002084_abnormal_developmental_patter1.16136627
65MP0008469_abnormal_protein_level1.14663473
66MP0004782_abnormal_surfactant_physiolog1.13500405
67MP0001293_anophthalmia1.13114829
68MP0001145_abnormal_male_reproductive1.10138931
69MP0000647_abnormal_sebaceous_gland1.09904128
70MP0002118_abnormal_lipid_homeostasis1.08020306
71MP0003724_increased_susceptibility_to1.07902808
72MP0002419_abnormal_innate_immunity1.07209474
73MP0003011_delayed_dark_adaptation1.05089869
74MP0002085_abnormal_embryonic_tissue1.04924184
75* MP0000598_abnormal_liver_morphology1.04737777
76MP0005584_abnormal_enzyme/coenzyme_acti1.04580856
77MP0009643_abnormal_urine_homeostasis1.03584996
78MP0006072_abnormal_retinal_apoptosis1.03337349
79MP0008932_abnormal_embryonic_tissue1.01523336
80MP0008789_abnormal_olfactory_epithelium1.00671857
81* MP0009763_increased_sensitivity_to0.99208993
82MP0002160_abnormal_reproductive_system0.97427991
83MP0003984_embryonic_growth_retardation0.96834814
84MP0000015_abnormal_ear_pigmentation0.94821250
85MP0002088_abnormal_embryonic_growth/wei0.94565481
86MP0009333_abnormal_splenocyte_physiolog0.94536910
87* MP0004215_abnormal_myocardial_fiber0.93699546
88MP0001986_abnormal_taste_sensitivity0.93443760
89MP0005025_abnormal_response_to0.93170427
90MP0008058_abnormal_DNA_repair0.92576764
91MP0010368_abnormal_lymphatic_system0.92550850
92MP0005636_abnormal_mineral_homeostasis0.92297468
93MP0003646_muscle_fatigue0.90313089
94MP0006292_abnormal_olfactory_placode0.90286205
95MP0001177_atelectasis0.89843811
96MP0005376_homeostasis/metabolism_phenot0.89703868
97MP0001727_abnormal_embryo_implantation0.89389794
98MP0001845_abnormal_inflammatory_respons0.89371397
99MP0003699_abnormal_female_reproductive0.88531047
100MP0002148_abnormal_hypersensitivity_rea0.87057109
101MP0003937_abnormal_limbs/digits/tail_de0.86422391
102MP0002796_impaired_skin_barrier0.86323817
103MP0002102_abnormal_ear_morphology0.86290739
104MP0002132_abnormal_respiratory_system0.85651123
105MP0002086_abnormal_extraembryonic_tissu0.85532138
106MP0002938_white_spotting0.85104250
107MP0004233_abnormal_muscle_weight0.85095193
108MP0008007_abnormal_cellular_replicative0.84166798
109MP0005000_abnormal_immune_tolerance0.81622096
110MP0005410_abnormal_fertilization0.81586930
111MP0001800_abnormal_humoral_immune0.81511142
112* MP0005384_cellular_phenotype0.80845652
113MP0002736_abnormal_nociception_after0.80790625
114MP0005220_abnormal_exocrine_pancreas0.79308705
115MP0009765_abnormal_xenobiotic_induced0.77212283
116MP0005464_abnormal_platelet_physiology0.75324569
117MP0002019_abnormal_tumor_incidence0.74670486
118MP0002452_abnormal_antigen_presenting0.74581484
119MP0004197_abnormal_fetal_growth/weight/0.73665496
120MP0002233_abnormal_nose_morphology0.73496346
121MP0002723_abnormal_immune_serum0.72737889
122MP0005266_abnormal_metabolism0.72014685
123MP0003698_abnormal_male_reproductive0.71998933
124MP0005647_abnormal_sex_gland0.70396522
125MP0009703_decreased_birth_body0.70363481
126MP0005501_abnormal_skin_physiology0.70116849
127MP0000604_amyloidosis0.69636091
128MP0000653_abnormal_sex_gland0.69615585
129MP0000343_altered_response_to0.68554271
130MP0002277_abnormal_respiratory_mucosa0.65698741
131* MP0009642_abnormal_blood_homeostasis0.65235630
132MP0001661_extended_life_span0.64976715
133MP0000689_abnormal_spleen_morphology0.64806589
134MP0008877_abnormal_DNA_methylation0.63962163
135MP0002876_abnormal_thyroid_physiology0.63687614
136MP0002161_abnormal_fertility/fecundity0.62743754
137* MP0008260_abnormal_autophagy0.62736252
138MP0005389_reproductive_system_phenotype0.61938088
139MP0005367_renal/urinary_system_phenotyp0.61424389
140MP0000516_abnormal_urinary_system0.61424389
141MP0005379_endocrine/exocrine_gland_phen0.61265732
142MP0005075_abnormal_melanosome_morpholog0.60088898
143MP0005387_immune_system_phenotype0.60035030
144MP0001790_abnormal_immune_system0.60035030
145MP0001533_abnormal_skeleton_physiology0.59338306
146MP0001853_heart_inflammation0.59315616
147MP0003121_genomic_imprinting0.58515764
148MP0005671_abnormal_response_to0.58388114
149* MP0008873_increased_physiological_sensi0.57443589
150MP0002163_abnormal_gland_morphology0.57092634
151MP0001188_hyperpigmentation0.56965910
152MP0001919_abnormal_reproductive_system0.56681831
153MP0001819_abnormal_immune_cell0.56588800
154MP0001915_intracranial_hemorrhage0.56437119
155MP0002282_abnormal_trachea_morphology0.56200765
156MP0000465_gastrointestinal_hemorrhage0.55797076
157MP0002420_abnormal_adaptive_immunity0.55577620
158MP0000858_altered_metastatic_potential0.55487732
159MP0006035_abnormal_mitochondrial_morpho0.55085392
160MP0008057_abnormal_DNA_replication0.54974838
161MP0000427_abnormal_hair_cycle0.54970535
162MP0000685_abnormal_immune_system0.54478471
163MP0002751_abnormal_autonomic_nervous0.53755564
164MP0001881_abnormal_mammary_gland0.53416552
165MP0002210_abnormal_sex_determination0.52978123
166MP0001730_embryonic_growth_arrest0.52745483

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.42465253
2Hypobetalipoproteinemia (HP:0003563)5.11567691
3Deep venous thrombosis (HP:0002625)4.86645948
4Intrahepatic cholestasis (HP:0001406)4.84076372
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.60101077
6Prolonged partial thromboplastin time (HP:0003645)4.28298877
7Xanthomatosis (HP:0000991)3.74758399
8Type I transferrin isoform profile (HP:0003642)3.62343244
9Hyperglycinemia (HP:0002154)3.56029043
10Abnormality of methionine metabolism (HP:0010901)3.54594538
11Abnormality of alanine metabolism (HP:0010916)3.51719753
12Hyperalaninemia (HP:0003348)3.51719753
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.51719753
14Hypolipoproteinemia (HP:0010981)3.39700149
15Joint hemorrhage (HP:0005261)3.37404794
16Abnormality of pyrimidine metabolism (HP:0004353)3.32242734
17Fat malabsorption (HP:0002630)3.30011460
18Hyperammonemia (HP:0001987)3.28572110
19Abnormality of aspartate family amino acid metabolism (HP:0010899)3.28190578
20Degeneration of anterior horn cells (HP:0002398)3.23516959
21Abnormality of the anterior horn cell (HP:0006802)3.23516959
22Abnormal protein N-linked glycosylation (HP:0012347)3.21350864
23Abnormal protein glycosylation (HP:0012346)3.21350864
24Abnormal glycosylation (HP:0012345)3.21350864
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.21350864
26Multiple enchondromatosis (HP:0005701)3.14498432
27Abnormality of the common coagulation pathway (HP:0010990)3.13416335
28Recurrent gram-negative bacterial infections (HP:0005420)3.10231031
29Complement deficiency (HP:0004431)3.10128902
30Hyperlipoproteinemia (HP:0010980)3.04915217
31Abnormality of sulfur amino acid metabolism (HP:0004339)2.98954406
32Microvesicular hepatic steatosis (HP:0001414)2.93704578
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93567826
34Conjugated hyperbilirubinemia (HP:0002908)2.90965192
35Abnormality of serum amino acid levels (HP:0003112)2.89831399
36Steatorrhea (HP:0002570)2.88602504
37Abnormality of the intrinsic pathway (HP:0010989)2.88328801
38Medulloblastoma (HP:0002885)2.79168023
39Increased serum pyruvate (HP:0003542)2.78898996
40Abnormality of glycolysis (HP:0004366)2.78898996
41Cerebral edema (HP:0002181)2.77817544
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77504288
43Ependymoma (HP:0002888)2.77140293
44Abnormality of fatty-acid metabolism (HP:0004359)2.74111153
45Lethargy (HP:0001254)2.73320568
46Hyperglycinuria (HP:0003108)2.72123689
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71595706
48Chromsome breakage (HP:0040012)2.70811728
49Birth length less than 3rd percentile (HP:0003561)2.69511021
50Acute encephalopathy (HP:0006846)2.64745074
51Abnormality of serine family amino acid metabolism (HP:0010894)2.64078557
52Abnormality of glycine metabolism (HP:0010895)2.64078557
53Agnosia (HP:0010524)2.59566331
54Meckel diverticulum (HP:0002245)2.56377327
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56080605
56Abnormality of chromosome stability (HP:0003220)2.55648440
57Abnormality of the labia minora (HP:0012880)2.53236515
58Colon cancer (HP:0003003)2.52497553
59Hepatic necrosis (HP:0002605)2.50866487
60Rhabdomyosarcoma (HP:0002859)2.49947795
61Abnormality of the ileum (HP:0001549)2.49716019
62Abnormality of the preputium (HP:0100587)2.48853837
63Hyperbilirubinemia (HP:0002904)2.45976590
64Glioma (HP:0009733)2.45584764
65Abnormality of nucleobase metabolism (HP:0010932)2.45167455
66Abnormality of complement system (HP:0005339)2.41186648
67Hypoalphalipoproteinemia (HP:0003233)2.39754768
68Stenosis of the external auditory canal (HP:0000402)2.38459035
69Ketosis (HP:0001946)2.35561585
70Systemic lupus erythematosus (HP:0002725)2.35428552
71Abnormal lung lobation (HP:0002101)2.35363799
72Recurrent bacterial skin infections (HP:0005406)2.34875262
73Neoplasm of the adrenal gland (HP:0100631)2.33701709
74Neoplasm of the colon (HP:0100273)2.31620839
75Epidermoid cyst (HP:0200040)2.31368678
76Breast hypoplasia (HP:0003187)2.31344639
77Posterior subcapsular cataract (HP:0007787)2.29993478
78Oral leukoplakia (HP:0002745)2.29869979
79Reduced antithrombin III activity (HP:0001976)2.28221242
80Abnormality of urine glucose concentration (HP:0011016)2.27452490
81Glycosuria (HP:0003076)2.27452490
82Secondary amenorrhea (HP:0000869)2.26974102
83Spontaneous abortion (HP:0005268)2.26581039
84Hepatocellular necrosis (HP:0001404)2.26563762
85Acute necrotizing encephalopathy (HP:0006965)2.26534107
86Duodenal stenosis (HP:0100867)2.24917570
87Small intestinal stenosis (HP:0012848)2.24917570
88Sparse eyelashes (HP:0000653)2.22999430
89Facial cleft (HP:0002006)2.19625623
90Hypoglycemic coma (HP:0001325)2.18775741
91Vacuolated lymphocytes (HP:0001922)2.18692556
92Aplasia/Hypoplasia of the uvula (HP:0010293)2.18046590
93Premature ovarian failure (HP:0008209)2.17893363
94Irregular epiphyses (HP:0010582)2.16295492
95Short tibia (HP:0005736)2.15071408
96Atrophy/Degeneration involving motor neurons (HP:0007373)2.13962278
97Lipid accumulation in hepatocytes (HP:0006561)2.13833587
98Increased CSF lactate (HP:0002490)2.11855764
99Generalized aminoaciduria (HP:0002909)2.11648237
100Abnormality of the astrocytes (HP:0100707)2.10979918
101Astrocytoma (HP:0009592)2.10979918
102Papillary thyroid carcinoma (HP:0002895)2.10218029
103Metabolic acidosis (HP:0001942)2.09249958
104Median cleft lip (HP:0000161)2.07712588
105Abnormal mitochondria in muscle tissue (HP:0008316)2.07677508
106Malnutrition (HP:0004395)2.07119251
107Supernumerary spleens (HP:0009799)2.06895102
108Dicarboxylic aciduria (HP:0003215)2.06888824
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06888824
110Exercise intolerance (HP:0003546)2.04594648
111Glomerulonephritis (HP:0000099)2.03920457
112Biliary tract neoplasm (HP:0100574)2.03859734
113Mitochondrial inheritance (HP:0001427)2.03758088
114Hypercholesterolemia (HP:0003124)2.02208605
115Abnormality of purine metabolism (HP:0004352)2.01629815
116Increased hepatocellular lipid droplets (HP:0006565)2.00809678
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00729035
118Renal Fanconi syndrome (HP:0001994)2.00614317
119Hepatocellular carcinoma (HP:0001402)2.00194870
120Carpal bone hypoplasia (HP:0001498)1.99028434
121Proximal tubulopathy (HP:0000114)1.97501706
122Neoplasm of the small intestine (HP:0100833)1.97296183
123CNS demyelination (HP:0007305)1.96638832
124Increased serum lactate (HP:0002151)1.94905933
125Nephroblastoma (Wilms tumor) (HP:0002667)1.94834776
126Embryonal renal neoplasm (HP:0011794)1.93852175
127Recurrent abscess formation (HP:0002722)1.92805830
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.92347671
129Methylmalonic aciduria (HP:0012120)1.91738806
130Aplastic anemia (HP:0001915)1.91012238
131Breast carcinoma (HP:0003002)1.90858209
132Methylmalonic acidemia (HP:0002912)1.89849797
133Cerebral hypomyelination (HP:0006808)1.89679840
134Aplasia/hypoplasia of the uterus (HP:0008684)1.87731893
135Cortical dysplasia (HP:0002539)1.87065969
136Lactic acidosis (HP:0003128)1.85964066
137Neoplasm of the rectum (HP:0100743)1.84690248
138Respiratory failure (HP:0002878)1.84518895
139Irritability (HP:0000737)1.84067220
140Sensory axonal neuropathy (HP:0003390)1.84012959
141Gout (HP:0001997)1.83320839
142Tongue fasciculations (HP:0001308)1.82936008
143Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82769056
144Brushfield spots (HP:0001088)1.82661843
1453-Methylglutaconic aciduria (HP:0003535)1.82265060
146Abnormality of the duodenum (HP:0002246)1.81459920
147Autoamputation (HP:0001218)1.79881828
148Respiratory difficulties (HP:0002880)1.79690630
149Amniotic constriction ring (HP:0009775)1.79535716
150Abnormality of placental membranes (HP:0011409)1.79535716
151Myocardial infarction (HP:0001658)1.79356121
152Exertional dyspnea (HP:0002875)1.78669738
153Nausea (HP:0002018)1.77303226
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76641472
155Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76641472
156Pancreatitis (HP:0001733)1.75756126
157Megaloblastic anemia (HP:0001889)1.74796232
158Progressive macrocephaly (HP:0004481)1.74782475
159Progressive inability to walk (HP:0002505)1.74440919
160Flat capital femoral epiphysis (HP:0003370)1.73548318
161Hyperphosphaturia (HP:0003109)1.73321303
162Renal cortical cysts (HP:0000803)1.72820291
163Postnatal microcephaly (HP:0005484)1.72803238
164Vomiting (HP:0002013)1.70985744
165Eczematoid dermatitis (HP:0000976)1.70421212
166CNS hypomyelination (HP:0003429)1.70163457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.21661132
2ARAF3.04933067
3ZAK2.82125571
4PLK42.79761012
5BCKDK2.78748633
6TRIM282.72424352
7TAOK32.70884374
8STK38L2.69236137
9ERBB42.66585577
10BUB12.56494139
11BRAF2.52650906
12MAP3K122.42601364
13BMPR22.29862351
14PDK22.21673274
15EIF2AK32.21314524
16PBK2.06756270
17NME22.00303643
18MAP4K21.96104891
19MOS1.93381157
20ABL21.91200829
21STK161.81306034
22MAP3K61.76914192
23PIM21.71403275
24TTK1.71172859
25MST41.70129134
26LATS11.70120094
27LATS21.68886847
28CDK81.68262467
29NEK91.65929824
30ERBB31.56649724
31MAP3K31.55165205
32MAP3K141.53641960
33ACVR1B1.52370596
34WEE11.39643277
35FLT31.38830464
36CDK191.30152589
37TYK21.28972136
38PLK11.27944120
39STK391.27388657
40VRK21.26560970
41RAF11.24128180
42MAPKAPK31.23401235
43BRSK21.22076152
44SCYL21.20881505
45MKNK21.18086433
46VRK11.17726866
47IRAK31.17400547
48SRPK11.17231205
49BRSK11.13299670
50RPS6KA41.12620347
51CDC71.12228984
52STK31.09243159
53TAF11.08255927
54AURKA1.07173623
55PAK41.05459501
56DYRK21.05034049
57PIK3CG1.04919599
58OXSR11.04682276
59MAP3K131.04064884
60CSNK1G21.03866329
61IRAK41.03062190
62MELK1.02683841
63CSNK1A1L0.98562099
64STK240.97368292
65STK100.96035464
66TBK10.95449510
67AURKB0.94878601
68NLK0.94411487
69PLK30.87070879
70CCNB10.86473007
71MAP3K80.86290739
72ATR0.84980361
73JAK30.84423390
74PIM10.83613606
75NEK20.83381344
76NUAK10.81956286
77MUSK0.81817754
78PLK20.79242546
79MAP3K50.77402691
80MAPK110.77243859
81IKBKB0.75493145
82PNCK0.71434871
83CSNK1G30.70415704
84TLK10.70319453
85KIT0.69324292
86NME10.68945523
87TNIK0.68414098
88WNK30.67747424
89CSNK1G10.66865485
90EIF2AK20.64745023
91CLK10.64549460
92DAPK10.63971344
93CHEK20.63655284
94IKBKE0.62480345
95NEK60.59514494
96TESK10.58092782
97ATM0.57487392
98CHEK10.56948290
99BMPR1B0.56655922
100MYLK0.56460905
101KSR20.55971989
102SIK30.55782100
103LIMK10.53523798
104TRPM70.52082417
105TEC0.51928990
106CSNK2A10.51746382
107MET0.50766903
108DYRK30.50659512
109TXK0.49090979
110CSNK2A20.48187942
111MINK10.47320547
112CDK70.47234876
113MAP2K30.46787255
114KDR0.46272699
115CDK40.43151099
116BCR0.42644772
117MAP3K40.42353261
118TGFBR10.41235800
119MAP3K110.41027394
120CSF1R0.40831423
121FGFR40.40706333
122LYN0.40681973
123EGFR0.40620395
124PASK0.38581134
125NEK10.38303631
126GRK70.37348449
127JAK20.36880339
128CHUK0.36352416
129ILK0.35861726
130CDK60.34377486
131STK40.34160914
132MAPK40.33783580
133TAOK20.33688573
134GRK60.33128009
135MST1R0.32568188
136ABL10.32473352
137TESK20.31750828
138TSSK60.31484027
139MAP4K10.31083452
140KSR10.28682754
141CSNK1E0.28117904
142CDK140.27454711
143RPS6KB20.27260871
144MKNK10.27203511
145CDK180.25674164
146PAK10.24843737
147PAK30.24176925

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.36888071
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75036430
3Proteasome_Homo sapiens_hsa030502.28396675
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25257195
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18095886
6Folate biosynthesis_Homo sapiens_hsa007902.11250091
7Complement and coagulation cascades_Homo sapiens_hsa046102.07529985
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04203714
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03490204
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01631731
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94593912
12Peroxisome_Homo sapiens_hsa041461.92584019
13Arginine biosynthesis_Homo sapiens_hsa002201.91390261
14Tryptophan metabolism_Homo sapiens_hsa003801.91175761
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89345243
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.85784720
17Protein export_Homo sapiens_hsa030601.78265574
18RNA polymerase_Homo sapiens_hsa030201.75703127
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70654314
20Chemical carcinogenesis_Homo sapiens_hsa052041.69204356
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68116171
22Caffeine metabolism_Homo sapiens_hsa002321.60711928
23Histidine metabolism_Homo sapiens_hsa003401.60024990
24Staphylococcus aureus infection_Homo sapiens_hsa051501.59957203
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.59783131
26Fatty acid degradation_Homo sapiens_hsa000711.57759847
27DNA replication_Homo sapiens_hsa030301.55331766
28One carbon pool by folate_Homo sapiens_hsa006701.53720752
29Vitamin B6 metabolism_Homo sapiens_hsa007501.53335319
30Retinol metabolism_Homo sapiens_hsa008301.48654043
31Steroid biosynthesis_Homo sapiens_hsa001001.47493723
32Selenocompound metabolism_Homo sapiens_hsa004501.47227810
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.46596171
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45909119
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45564467
36Phenylalanine metabolism_Homo sapiens_hsa003601.41985121
37Pyrimidine metabolism_Homo sapiens_hsa002401.38296868
38Homologous recombination_Homo sapiens_hsa034401.32370243
39Propanoate metabolism_Homo sapiens_hsa006401.26998279
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25225777
41Mismatch repair_Homo sapiens_hsa034301.24337684
42mRNA surveillance pathway_Homo sapiens_hsa030151.24233883
43beta-Alanine metabolism_Homo sapiens_hsa004101.22441440
44Tyrosine metabolism_Homo sapiens_hsa003501.21935520
45Butanoate metabolism_Homo sapiens_hsa006501.21563516
46Alzheimers disease_Homo sapiens_hsa050101.20669944
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20445780
48Basal transcription factors_Homo sapiens_hsa030221.16868893
49Oocyte meiosis_Homo sapiens_hsa041141.16496499
50Sulfur metabolism_Homo sapiens_hsa009201.14556385
51Pyruvate metabolism_Homo sapiens_hsa006201.12275658
52Glutathione metabolism_Homo sapiens_hsa004801.11983701
53Nucleotide excision repair_Homo sapiens_hsa034201.10980414
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09781915
55Sulfur relay system_Homo sapiens_hsa041221.04461400
56Biosynthesis of amino acids_Homo sapiens_hsa012301.04321088
57Nitrogen metabolism_Homo sapiens_hsa009101.02861022
58Arginine and proline metabolism_Homo sapiens_hsa003301.02540227
59Fatty acid elongation_Homo sapiens_hsa000621.01471486
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.99633473
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96530179
62Fatty acid metabolism_Homo sapiens_hsa012120.95793415
63Base excision repair_Homo sapiens_hsa034100.94270569
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94202083
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93782166
66RNA degradation_Homo sapiens_hsa030180.92508677
67Starch and sucrose metabolism_Homo sapiens_hsa005000.92319245
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90723400
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90567160
70Non-homologous end-joining_Homo sapiens_hsa034500.89552335
71PPAR signaling pathway_Homo sapiens_hsa033200.88761192
72Cell cycle_Homo sapiens_hsa041100.88743049
73Ribosome_Homo sapiens_hsa030100.88680629
74Carbon metabolism_Homo sapiens_hsa012000.86640413
75Pentose phosphate pathway_Homo sapiens_hsa000300.85440705
76Other glycan degradation_Homo sapiens_hsa005110.85267218
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84588686
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81495441
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79935975
80* Regulation of autophagy_Homo sapiens_hsa041400.79372836
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78814865
82Vitamin digestion and absorption_Homo sapiens_hsa049770.73835095
83RNA transport_Homo sapiens_hsa030130.73044523
84N-Glycan biosynthesis_Homo sapiens_hsa005100.71746546
85Metabolic pathways_Homo sapiens_hsa011000.70833889
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69580811
87Oxidative phosphorylation_Homo sapiens_hsa001900.68659466
88Epstein-Barr virus infection_Homo sapiens_hsa051690.59378697
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59114997
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.56940136
91Legionellosis_Homo sapiens_hsa051340.56194272
92Purine metabolism_Homo sapiens_hsa002300.52075513
93Parkinsons disease_Homo sapiens_hsa050120.51978242
94Fat digestion and absorption_Homo sapiens_hsa049750.51073651
95* Shigellosis_Homo sapiens_hsa051310.50469248
96Galactose metabolism_Homo sapiens_hsa000520.48874757
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48010003
98Linoleic acid metabolism_Homo sapiens_hsa005910.45444408
99Fructose and mannose metabolism_Homo sapiens_hsa000510.44433312
100Circadian rhythm_Homo sapiens_hsa047100.40793531
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39940870
102Bile secretion_Homo sapiens_hsa049760.39225493
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39201426
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38405886
105Collecting duct acid secretion_Homo sapiens_hsa049660.37261929
106Fanconi anemia pathway_Homo sapiens_hsa034600.36846792
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36021529
108ABC transporters_Homo sapiens_hsa020100.35461087
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33947555
110Arachidonic acid metabolism_Homo sapiens_hsa005900.32395400
111Huntingtons disease_Homo sapiens_hsa050160.31781348
112p53 signaling pathway_Homo sapiens_hsa041150.31292731
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30942614
114Cardiac muscle contraction_Homo sapiens_hsa042600.30533029
115Spliceosome_Homo sapiens_hsa030400.30318266
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25376759
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25132717
118Phototransduction_Homo sapiens_hsa047440.19281568
119TGF-beta signaling pathway_Homo sapiens_hsa043500.18820019
120Herpes simplex infection_Homo sapiens_hsa051680.16336910
121Vibrio cholerae infection_Homo sapiens_hsa051100.14377679
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10642833
123Viral carcinogenesis_Homo sapiens_hsa052030.08677327

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