ATG9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)4.60664741
2sperm motility (GO:0030317)4.58972692
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.31934889
4cellular response to nitric oxide (GO:0071732)4.31299334
5acrosome reaction (GO:0007340)4.13266490
6Golgi transport vesicle coating (GO:0048200)4.05941931
7COPI coating of Golgi vesicle (GO:0048205)4.05941931
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.91993474
9protein retention in ER lumen (GO:0006621)3.91453823
10cytoskeletal anchoring at plasma membrane (GO:0007016)3.90254555
11CDP-diacylglycerol metabolic process (GO:0046341)3.83362432
12CDP-diacylglycerol biosynthetic process (GO:0016024)3.69360335
13fusion of sperm to egg plasma membrane (GO:0007342)3.68805121
14regulation of early endosome to late endosome transport (GO:2000641)3.66488354
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64099242
16membrane depolarization during action potential (GO:0086010)3.53958737
17neuromuscular process controlling posture (GO:0050884)3.52211321
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52056710
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.50523522
20protein localization to endosome (GO:0036010)3.49711039
21synaptic vesicle maturation (GO:0016188)3.49054895
22protein targeting to plasma membrane (GO:0072661)3.47493068
23negative regulation of inclusion body assembly (GO:0090084)3.47439471
24focal adhesion assembly (GO:0048041)3.47207626
25cell-substrate adherens junction assembly (GO:0007045)3.47207626
26response to nitrosative stress (GO:0051409)3.42946396
27cell-substrate junction assembly (GO:0007044)3.42560513
28neurotransmitter-gated ion channel clustering (GO:0072578)3.42441902
29regulation of cholesterol homeostasis (GO:2000188)3.42261873
30adherens junction assembly (GO:0034333)3.38577898
31peptidyl-threonine dephosphorylation (GO:0035970)3.36759635
32regulation of synapse structural plasticity (GO:0051823)3.35141258
33cellular response to reactive nitrogen species (GO:1902170)3.33820942
34basement membrane organization (GO:0071711)3.33476363
35vocalization behavior (GO:0071625)3.33463882
36regulation of synaptic vesicle transport (GO:1902803)3.30365139
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29826641
38proline biosynthetic process (GO:0006561)3.28888815
39barbed-end actin filament capping (GO:0051016)3.28424885
40plasma membrane fusion (GO:0045026)3.27670896
41organic cation transport (GO:0015695)3.25895630
42negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.25868021
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.22885980
44regulation of energy homeostasis (GO:2000505)3.18046184
45* mitochondrion degradation (GO:0000422)3.17950919
46positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16595480
47calcium ion-dependent exocytosis (GO:0017156)3.16160836
48response to nitric oxide (GO:0071731)3.13032046
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11801223
50regulation of synaptic vesicle exocytosis (GO:2000300)3.10541487
51very-low-density lipoprotein particle assembly (GO:0034379)3.10185556
52regulation of cholesterol biosynthetic process (GO:0045540)3.09336111
53protein carboxylation (GO:0018214)3.08690247
54peptidyl-glutamic acid carboxylation (GO:0017187)3.08690247
55acrosome assembly (GO:0001675)3.06130296
56postsynaptic membrane organization (GO:0001941)3.05128128
57stress fiber assembly (GO:0043149)3.03775396
58glucose 6-phosphate metabolic process (GO:0051156)3.00074103
59positive regulation of membrane potential (GO:0045838)2.99664679
60protein-lipid complex assembly (GO:0065005)2.99240176
61urea cycle (GO:0000050)2.97384659
62urea metabolic process (GO:0019627)2.97384659
63multicellular organism reproduction (GO:0032504)2.97030147
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96508263
65carnitine transmembrane transport (GO:1902603)2.96105344
66protein localization to synapse (GO:0035418)2.94854361
67amino-acid betaine metabolic process (GO:0006577)2.94705222
68hemidesmosome assembly (GO:0031581)2.93552756
69regulation of glutamate receptor signaling pathway (GO:1900449)2.91876304
70amino-acid betaine transport (GO:0015838)2.91194249
71carnitine transport (GO:0015879)2.91194249
72synaptic transmission, glutamatergic (GO:0035249)2.89857185
73cell communication by electrical coupling (GO:0010644)2.88897890
74fructose metabolic process (GO:0006000)2.88438000
75sperm capacitation (GO:0048240)2.88312894
76positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88039525
77regulation of cilium movement (GO:0003352)2.87684703
78desmosome organization (GO:0002934)2.86295470
79locomotory exploration behavior (GO:0035641)2.85515995
80cell wall macromolecule catabolic process (GO:0016998)2.85503182
81cell wall macromolecule metabolic process (GO:0044036)2.85503182
82negative regulation of erythrocyte differentiation (GO:0045647)2.85406723
83positive regulation of gluconeogenesis (GO:0045722)2.82866212
84gamma-aminobutyric acid transport (GO:0015812)2.79291717
85regulation of inclusion body assembly (GO:0090083)2.77651282
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77640397
874-hydroxyproline metabolic process (GO:0019471)2.75169963
88synaptic vesicle docking involved in exocytosis (GO:0016081)2.74709046
89plasma lipoprotein particle assembly (GO:0034377)2.73783184
90cellular potassium ion homeostasis (GO:0030007)2.73606246
91sodium ion export (GO:0071436)2.73231607
92presynaptic membrane assembly (GO:0097105)2.72895567
93regulation of ARF protein signal transduction (GO:0032012)2.71901507
94regulation of extracellular matrix disassembly (GO:0010715)2.71635482
95creatine metabolic process (GO:0006600)2.71619238
96proline metabolic process (GO:0006560)2.71145059
97apoptotic process involved in morphogenesis (GO:0060561)2.70832815
98regulation of neuronal synaptic plasticity (GO:0048168)2.69924297
99carnitine metabolic process (GO:0009437)2.68984775
100cerebellar Purkinje cell layer development (GO:0021680)2.68824411
101glutamate secretion (GO:0014047)2.68647848
102nitrogen cycle metabolic process (GO:0071941)2.67886134
103modulation by virus of host morphology or physiology (GO:0019048)2.66929184
104positive regulation of synapse maturation (GO:0090129)2.66655297
105regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65343718
106peptidyl-proline hydroxylation (GO:0019511)2.65275141
107synaptic vesicle exocytosis (GO:0016079)2.64087167
108positive regulation of receptor recycling (GO:0001921)2.63662439
109positive regulation of triglyceride biosynthetic process (GO:0010867)2.63452520
110mannose metabolic process (GO:0006013)2.61808704
111spermatid development (GO:0007286)2.61394510
112reproduction (GO:0000003)2.61370255
113neurotransmitter secretion (GO:0007269)2.58999638
114regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58711300
115sperm-egg recognition (GO:0035036)2.58265454
116skin morphogenesis (GO:0043589)2.57520111
117glutamate receptor signaling pathway (GO:0007215)2.56301897
118cell volume homeostasis (GO:0006884)2.56261465
119dendritic spine morphogenesis (GO:0060997)2.55415393
120regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55246838
121NADH metabolic process (GO:0006734)2.53921879
122serine family amino acid catabolic process (GO:0009071)2.52338442
123positive regulation of extracellular matrix organization (GO:1903055)2.50571204
124regulation of cholesterol metabolic process (GO:0090181)2.50137095
125long-term memory (GO:0007616)2.49585985
126sulfur amino acid catabolic process (GO:0000098)2.49173749
127cerebellar granule cell differentiation (GO:0021707)2.48396797
128activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.48396337
129regulation of triglyceride biosynthetic process (GO:0010866)2.47551652
130negative regulation of cell size (GO:0045792)2.47507633
131regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46333950
132actin filament depolymerization (GO:0030042)2.46245271
133semaphorin-plexin signaling pathway (GO:0071526)2.45615992
134gluconeogenesis (GO:0006094)2.45473907
135protein maturation by protein folding (GO:0022417)2.45456198
136calcium ion import (GO:0070509)2.45341558
137cell communication involved in cardiac conduction (GO:0086065)2.45211326
138epithelial cell-cell adhesion (GO:0090136)2.44989628
139alditol metabolic process (GO:0019400)2.42438244
140positive regulation of triglyceride metabolic process (GO:0090208)2.42136781
141neuron-neuron synaptic transmission (GO:0007270)2.41912452
142positive regulation of dendritic spine development (GO:0060999)2.41824966
143protoporphyrinogen IX metabolic process (GO:0046501)2.41823829
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41764681
145membrane depolarization (GO:0051899)2.40698446
146triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40691712
147disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.40134901
148killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.40134901
149regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.39952532
150cranial nerve morphogenesis (GO:0021602)2.39895056
151negative regulation of fibrinolysis (GO:0051918)2.39626272
152receptor recycling (GO:0001881)2.39367881
153positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39140766
154regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37868553
155cell-cell junction maintenance (GO:0045217)2.37458291
156layer formation in cerebral cortex (GO:0021819)2.37319691
157growth hormone secretion (GO:0030252)2.37179268
158protein hydroxylation (GO:0018126)2.35770510
159low-density lipoprotein particle clearance (GO:0034383)2.35743385
160positive regulation of lipoprotein lipase activity (GO:0051006)2.35622890
161positive regulation of triglyceride lipase activity (GO:0061365)2.35622890
162modulation by symbiont of host cellular process (GO:0044068)2.34884658
163hexose biosynthetic process (GO:0019319)2.34274511
164monosaccharide biosynthetic process (GO:0046364)2.34180307
165positive regulation of nuclease activity (GO:0032075)2.34157742
166negative regulation of fatty acid transport (GO:2000192)2.33499930
167endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.32578337
168activation of Rac GTPase activity (GO:0032863)2.30861610
169pinocytosis (GO:0006907)2.30120547
170regulation of response to osmotic stress (GO:0047484)2.29969989
171positive regulation of protein dephosphorylation (GO:0035307)2.29539325
172modulation by virus of host process (GO:0019054)2.27050474
173negative regulation of protein localization to plasma membrane (GO:1903077)2.26969140
174pentose-phosphate shunt (GO:0006098)2.26748659
175glucose catabolic process (GO:0006007)2.26324486
176glycolytic process (GO:0006096)2.25825369
177regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.24091430
178embryonic process involved in female pregnancy (GO:0060136)2.23312999
179actin filament capping (GO:0051693)2.22472679
180vesicle coating (GO:0006901)2.22349208
181positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.22173352
182regulation of extracellular matrix organization (GO:1903053)2.21420663
183L-serine transport (GO:0015825)2.21032932
184endocytic recycling (GO:0032456)2.19289858
185positive regulation of myotube differentiation (GO:0010831)2.18390268
186regulation of ARF GTPase activity (GO:0032312)2.16509207
187regulation of glucose import in response to insulin stimulus (GO:2001273)2.16413179
188negative regulation of fatty acid biosynthetic process (GO:0045717)2.14815000
189maternal placenta development (GO:0001893)2.14096642
190hemoglobin metabolic process (GO:0020027)2.12280980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.69254669
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.28193168
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.15334893
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.09012929
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.93182960
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.48062600
7RACK7_27058665_Chip-Seq_MCF-7_Human2.27018365
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25050049
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.16673125
10* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09102260
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99978683
12ZFP281_18757296_ChIP-ChIP_E14_Mouse1.97253902
13* REST_21632747_ChIP-Seq_MESCs_Mouse1.96770914
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95529520
15RARB_27405468_Chip-Seq_BRAIN_Mouse1.90097198
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88925730
17PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88263833
18TCF7_22412390_ChIP-Seq_EML_Mouse1.84816558
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.81887682
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81221552
21VDR_21846776_ChIP-Seq_THP-1_Human1.80277185
22CLOCK_20551151_ChIP-Seq_293T_Human1.77501860
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75339484
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73072605
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72515052
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.72214140
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.70599720
28MYC_22102868_ChIP-Seq_BL_Human1.70547380
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68854870
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67609652
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67063786
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63489714
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62499213
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.61723328
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61307602
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.61185737
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60635157
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59591262
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58763102
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58288857
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.56802201
42DROSHA_22980978_ChIP-Seq_HELA_Human1.56387353
43CTCF_27219007_Chip-Seq_Bcells_Human1.55255516
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54872622
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54341775
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51218857
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50700501
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47867540
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.46901499
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45821382
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44239351
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43128725
53CREB1_26743006_Chip-Seq_LNCaP_Human1.41061161
54LXR_22292898_ChIP-Seq_THP-1_Human1.40821960
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40270731
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40147383
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39180097
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38638240
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38086959
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.37762141
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.37599910
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37199091
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37199091
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36863414
65* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35083944
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.34083607
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31680756
68ZNF274_21170338_ChIP-Seq_K562_Hela1.30041573
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29775522
70GBX2_23144817_ChIP-Seq_PC3_Human1.29583307
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29002826
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28774340
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28431517
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27309270
75ATF3_27146783_Chip-Seq_COLON_Human1.26107446
76* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25025997
77SA1_27219007_Chip-Seq_Bcells_Human1.22207401
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21238933
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21085528
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20978172
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20826121
82* TP53_22127205_ChIP-Seq_IMR90_Human1.20537755
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19349839
84SMC4_20622854_ChIP-Seq_HELA_Human1.19106932
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18708876
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18165314
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17714556
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17102345
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16635151
90NCOR1_26117541_ChIP-Seq_K562_Human1.16618714
91KDM2B_26808549_Chip-Seq_K562_Human1.15529210
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14064178
93GATA1_19941826_ChIP-Seq_K562_Human1.13946921
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13545813
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11357411
96P68_20966046_ChIP-Seq_HELA_Human1.11281332
97TBX20_22080862_ChIP-Seq_HEART_Mouse1.10338934
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.10338934
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09893192
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09851916
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08823913
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08118461
103BCOR_27268052_Chip-Seq_Bcells_Human1.07716752
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.07162830
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.07076099
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07067897
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06732706
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06241020
109BCL6_27268052_Chip-Seq_Bcells_Human1.05584669
110ZNF263_19887448_ChIP-Seq_K562_Human1.05215405
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04435178
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03818254
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03634189
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03387723
115TP63_22573176_ChIP-Seq_HFKS_Human1.03364547
116GATA3_21867929_ChIP-Seq_CD8_Mouse1.03133905
117* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02471488
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02103508
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01570996
120CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01295373
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01265870
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00875226
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00838333
124SOX2_21211035_ChIP-Seq_LN229_Human1.00574618
125RARA_24833708_ChIP-Seq_LIVER_Mouse1.00430497
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00125291
127SA1_27219007_Chip-Seq_ERYTHROID_Human0.99668119
128EZH2_27304074_Chip-Seq_ESCs_Mouse0.99234006
129SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99092640
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98974582
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.98510197
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97658194
133P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97529526
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97265703
135PHF8_20622854_ChIP-Seq_HELA_Human0.97175679
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95568497
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95234310
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95051991
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.94380179
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94240889
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.93362724
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91851487
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90317305
144KLF4_19829295_ChIP-Seq_ESCs_Human0.90197045
145* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89344171
146SPI1_23127762_ChIP-Seq_K562_Human0.89186118
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88610814
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88458907
149OCT4_19829295_ChIP-Seq_ESCs_Human0.88181967
150KDM2B_26808549_Chip-Seq_DND41_Human0.87104592
151GATA2_19941826_ChIP-Seq_K562_Human0.86492348
152TET1_21490601_ChIP-Seq_MESCs_Mouse0.85230979
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85148059
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84544437
155SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84400812
156STAT1_17558387_ChIP-Seq_HELA_Human0.84398423
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83743244
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83343516
159ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82865126
160FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82374718
161* P53_21459846_ChIP-Seq_SAOS-2_Human0.82155921
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81637855
163JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81218105
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80767713
165E2F1_20622854_ChIP-Seq_HELA_Human0.80712270
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78471985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.45858329
2MP0002139_abnormal_hepatobiliary_system4.31839130
3MP0005451_abnormal_body_composition4.21805414
4MP0003646_muscle_fatigue4.16235536
5MP0004859_abnormal_synaptic_plasticity4.15153948
6MP0005410_abnormal_fertilization3.89810316
7MP0008438_abnormal_cutaneous_collagen3.39381743
8MP0003880_abnormal_central_pattern3.16533435
9MP0003566_abnormal_cell_adhesion2.93857435
10MP0003635_abnormal_synaptic_transmissio2.54583477
11MP0000751_myopathy2.53284031
12MP0004858_abnormal_nervous_system2.41186610
13MP0002837_dystrophic_cardiac_calcinosis2.39664205
14MP0005360_urolithiasis2.39593272
15MP0002822_catalepsy2.32359259
16MP0001849_ear_inflammation2.24790641
17MP0009840_abnormal_foam_cell2.23064058
18MP0003879_abnormal_hair_cell2.21120225
19MP0004272_abnormal_basement_membrane2.18395187
20MP0004270_analgesia2.16248411
21MP0003172_abnormal_lysosome_physiology2.15985125
22MP0010329_abnormal_lipoprotein_level2.14257707
23MP0005085_abnormal_gallbladder_physiolo2.13986469
24MP0004233_abnormal_muscle_weight2.13622384
25MP0005365_abnormal_bile_salt2.11245013
26MP0009745_abnormal_behavioral_response2.01457016
27MP0002064_seizures2.01380430
28MP0009046_muscle_twitch2.00154286
29MP0001968_abnormal_touch/_nociception1.94327386
30MP0000003_abnormal_adipose_tissue1.89955446
31* MP0008260_abnormal_autophagy1.88987489
32MP0005257_abnormal_intraocular_pressure1.86177977
33MP0003656_abnormal_erythrocyte_physiolo1.85025700
34MP0003329_amyloid_beta_deposits1.83968157
35MP0009780_abnormal_chondrocyte_physiolo1.75906504
36MP0004145_abnormal_muscle_electrophysio1.75113521
37MP0002063_abnormal_learning/memory/cond1.73709012
38MP0002876_abnormal_thyroid_physiology1.70449742
39MP0008569_lethality_at_weaning1.66668896
40MP0002089_abnormal_postnatal_growth/wei1.62921928
41MP0003279_aneurysm1.62790465
42MP0002272_abnormal_nervous_system1.62192205
43MP0005076_abnormal_cell_differentiation1.60423262
44MP0000749_muscle_degeneration1.55017860
45MP0008875_abnormal_xenobiotic_pharmacok1.54197328
46MP0000678_abnormal_parathyroid_gland1.53428280
47MP0002009_preneoplasia1.53285017
48MP0000013_abnormal_adipose_tissue1.51877731
49MP0001958_emphysema1.50842919
50MP0003453_abnormal_keratinocyte_physiol1.50839454
51MP0004130_abnormal_muscle_cell1.49945793
52MP0003698_abnormal_male_reproductive1.49837697
53MP0005623_abnormal_meninges_morphology1.48465302
54MP0004484_altered_response_of1.45873626
55MP0002877_abnormal_melanocyte_morpholog1.45088762
56MP0002734_abnormal_mechanical_nocicepti1.43613181
57MP0005375_adipose_tissue_phenotype1.43183782
58MP0005330_cardiomyopathy1.39266184
59MP0005409_darkened_coat_color1.38671201
60MP0002735_abnormal_chemical_nociception1.35996752
61MP0005423_abnormal_somatic_nervous1.35030012
62MP0005670_abnormal_white_adipose1.34421276
63MP0002572_abnormal_emotion/affect_behav1.33820173
64MP0006138_congestive_heart_failure1.31843968
65MP0010630_abnormal_cardiac_muscle1.29587734
66MP0001970_abnormal_pain_threshold1.29187217
67MP0002118_abnormal_lipid_homeostasis1.27506008
68MP0003091_abnormal_cell_migration1.26716510
69MP0010234_abnormal_vibrissa_follicle1.26442843
70MP0002249_abnormal_larynx_morphology1.26019205
71MP0002067_abnormal_sensory_capabilities1.25615521
72MP0000733_abnormal_muscle_development1.25588351
73MP0010030_abnormal_orbit_morphology1.24963027
74MP0002736_abnormal_nociception_after1.23283421
75MP0005083_abnormal_biliary_tract1.23029405
76MP0004185_abnormal_adipocyte_glucose1.22288456
77MP0004036_abnormal_muscle_relaxation1.21894485
78MP0005666_abnormal_adipose_tissue1.21191100
79MP0005275_abnormal_skin_tensile1.20663841
80MP0002909_abnormal_adrenal_gland1.19878459
81MP0006036_abnormal_mitochondrial_physio1.19805123
82MP0001501_abnormal_sleep_pattern1.18611945
83MP0005535_abnormal_body_temperature1.17237690
84MP0004215_abnormal_myocardial_fiber1.16304764
85MP0001486_abnormal_startle_reflex1.16065802
86MP0003075_altered_response_to1.15981554
87MP0001984_abnormal_olfaction1.15560467
88MP0005023_abnormal_wound_healing1.15496168
89MP0009384_cardiac_valve_regurgitation1.14732421
90MP0005332_abnormal_amino_acid1.14110134
91MP0003123_paternal_imprinting1.14031937
92MP0005501_abnormal_skin_physiology1.13752511
93MP0001440_abnormal_grooming_behavior1.12026360
94MP0000747_muscle_weakness1.11383088
95MP0002733_abnormal_thermal_nociception1.10380670
96MP0002060_abnormal_skin_morphology1.09191940
97MP0000681_abnormal_thyroid_gland1.08971647
98MP0003633_abnormal_nervous_system1.08607227
99MP0008874_decreased_physiological_sensi1.07267576
100MP0002796_impaired_skin_barrier1.06521208
101MP0001502_abnormal_circadian_rhythm1.04902916
102MP0004142_abnormal_muscle_tone1.03649498
103MP0001915_intracranial_hemorrhage1.02554192
104MP0008004_abnormal_stomach_pH1.02546161
105MP0004811_abnormal_neuron_physiology1.00910920
106MP0002106_abnormal_muscle_physiology1.00542624
107MP0000767_abnormal_smooth_muscle1.00423402
108MP0005584_abnormal_enzyme/coenzyme_acti1.00255715
109MP0006035_abnormal_mitochondrial_morpho1.00247089
110MP0000579_abnormal_nail_morphology0.99888536
111MP0000604_amyloidosis0.99783447
112MP0001765_abnormal_ion_homeostasis0.98496227
113MP0005166_decreased_susceptibility_to0.98224388
114MP0002971_abnormal_brown_adipose0.97919975
115MP0001929_abnormal_gametogenesis0.97452692
116MP0005319_abnormal_enzyme/_coenzyme0.94901666
117MP0010368_abnormal_lymphatic_system0.94555084
118MP0003634_abnormal_glial_cell0.92093889
119MP0004510_myositis0.91962888
120MP0000467_abnormal_esophagus_morphology0.91540125
121MP0002269_muscular_atrophy0.91202538
122MP0001348_abnormal_lacrimal_gland0.91019309
123MP0002078_abnormal_glucose_homeostasis0.90902133
124MP0000566_synostosis0.90170100
125MP0004084_abnormal_cardiac_muscle0.88769871
126MP0002896_abnormal_bone_mineralization0.88123067
127MP0006276_abnormal_autonomic_nervous0.86949177
128MP0005058_abnormal_lysosome_morphology0.86852919
129MP0000465_gastrointestinal_hemorrhage0.86445087
130MP0002166_altered_tumor_susceptibility0.86416193
131MP0000920_abnormal_myelination0.85754354
132MP0000858_altered_metastatic_potential0.84040426
133MP0003191_abnormal_cellular_cholesterol0.83700903
134MP0000609_abnormal_liver_physiology0.83694525
135MP0004264_abnormal_extraembryonic_tissu0.83540874
136MP0000762_abnormal_tongue_morphology0.83236198
137MP0001764_abnormal_homeostasis0.82968545
138MP0005636_abnormal_mineral_homeostasis0.82100175
139MP0000759_abnormal_skeletal_muscle0.81319159
140MP0002066_abnormal_motor_capabilities/c0.81132936
141MP0004087_abnormal_muscle_fiber0.80930715
142MP0008872_abnormal_physiological_respon0.80836469
143MP0005464_abnormal_platelet_physiology0.79836154
144MP0000534_abnormal_ureter_morphology0.79733653
145MP0003195_calcinosis0.78204904
146MP0005620_abnormal_muscle_contractility0.78180376
147MP0002557_abnormal_social/conspecific_i0.76498365
148MP0003303_peritoneal_inflammation0.75472352
149MP0002161_abnormal_fertility/fecundity0.74500298
150MP0005386_behavior/neurological_phenoty0.74144437
151MP0004924_abnormal_behavior0.74144437
152MP0003953_abnormal_hormone_level0.72808243
153MP0000015_abnormal_ear_pigmentation0.72007822
154MP0002972_abnormal_cardiac_muscle0.71898274
155* MP0005621_abnormal_cell_physiology0.71151646
156MP0000750_abnormal_muscle_regeneration0.70647931
157MP0005369_muscle_phenotype0.70266053
158MP0003115_abnormal_respiratory_system0.69954101
159MP0001661_extended_life_span0.68770745
160MP0009931_abnormal_skin_appearance0.68531937
161MP0009278_abnormal_bone_marrow0.65882990
162MP0002108_abnormal_muscle_morphology0.63609427
163MP0003385_abnormal_body_wall0.59869742
164MP0000462_abnormal_digestive_system0.58199312

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.85167322
2Reduced antithrombin III activity (HP:0001976)4.06883139
3Myokymia (HP:0002411)4.01827504
4Protrusio acetabuli (HP:0003179)3.90134445
5Bundle branch block (HP:0011710)3.81578633
6Exercise-induced myalgia (HP:0003738)3.72474278
7Focal seizures (HP:0007359)3.70841294
8Ventricular fibrillation (HP:0001663)3.65561579
9Premature rupture of membranes (HP:0001788)3.60468773
10Absent/shortened dynein arms (HP:0200106)3.56893976
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.56893976
12Cerebral aneurysm (HP:0004944)3.07740240
13Increased connective tissue (HP:0009025)3.07266741
14Type 1 muscle fiber predominance (HP:0003803)3.05363636
15Prolonged partial thromboplastin time (HP:0003645)2.95125041
16Distal lower limb amyotrophy (HP:0008944)2.92241612
17Hyperglycinuria (HP:0003108)2.89854490
18Distal lower limb muscle weakness (HP:0009053)2.89371266
19Gout (HP:0001997)2.88059473
20Centrally nucleated skeletal muscle fibers (HP:0003687)2.84697835
21Exercise-induced muscle cramps (HP:0003710)2.84104510
22Hyperglycinemia (HP:0002154)2.82911040
23Increased variability in muscle fiber diameter (HP:0003557)2.82858792
24Visual hallucinations (HP:0002367)2.82709412
25Type I transferrin isoform profile (HP:0003642)2.70274483
26Abnormality of skeletal muscle fiber size (HP:0012084)2.69593980
27Vertebral compression fractures (HP:0002953)2.69262733
28Spinal rigidity (HP:0003306)2.65193811
29Heart block (HP:0012722)2.62419294
30Infertility (HP:0000789)2.62258716
31Obstructive sleep apnea (HP:0002870)2.62249455
32Atrioventricular block (HP:0001678)2.60372913
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60003584
34Abnormality of the Achilles tendon (HP:0005109)2.58715595
35Distal upper limb amyotrophy (HP:0007149)2.58626260
36Upper limb amyotrophy (HP:0009129)2.58626260
37Achilles tendon contracture (HP:0001771)2.57090662
38Thoracic kyphosis (HP:0002942)2.54617888
39Febrile seizures (HP:0002373)2.53233661
40Syncope (HP:0001279)2.52711928
41Status epilepticus (HP:0002133)2.45241346
42Abnormal eating behavior (HP:0100738)2.45232365
43Dysmetric saccades (HP:0000641)2.42330924
44Mildly elevated creatine phosphokinase (HP:0008180)2.41804286
45Hemorrhage of the eye (HP:0011885)2.41433694
46Hyperacusis (HP:0010780)2.40622640
47Supranuclear gaze palsy (HP:0000605)2.39624233
48Depression (HP:0000716)2.38728126
49Calf muscle hypertrophy (HP:0008981)2.38046881
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37135076
51Progressive cerebellar ataxia (HP:0002073)2.37030191
52Sudden death (HP:0001699)2.36785645
53Lower limb amyotrophy (HP:0007210)2.36746466
54Abnormal atrioventricular conduction (HP:0005150)2.35756157
55Myoglobinuria (HP:0002913)2.35700742
56Ulnar bowing (HP:0003031)2.33721170
57Hemiplegia (HP:0002301)2.32179721
58Progressive muscle weakness (HP:0003323)2.31685886
59Abnormality of glycine metabolism (HP:0010895)2.31512448
60Abnormality of serine family amino acid metabolism (HP:0010894)2.31512448
61Fragile skin (HP:0001030)2.31007090
62Cerebral inclusion bodies (HP:0100314)2.28136964
63Action tremor (HP:0002345)2.27356845
64Gaze-evoked nystagmus (HP:0000640)2.27073937
65Late onset (HP:0003584)2.25896493
66Postural instability (HP:0002172)2.24268230
67Muscle fiber inclusion bodies (HP:0100299)2.23811468
68Muscle hypertrophy of the lower extremities (HP:0008968)2.23754198
69Hemiparesis (HP:0001269)2.23260284
70Nemaline bodies (HP:0003798)2.23105710
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.23015466
72Shallow orbits (HP:0000586)2.22758460
73Atrophic scars (HP:0001075)2.21998102
74Spastic tetraparesis (HP:0001285)2.20840593
75Abnormal social behavior (HP:0012433)2.20660223
76Impaired social interactions (HP:0000735)2.20660223
77Xanthomatosis (HP:0000991)2.20113552
78Hyperlipoproteinemia (HP:0010980)2.20030891
79Insomnia (HP:0100785)2.18978175
80Round ear (HP:0100830)2.18113216
81Ketosis (HP:0001946)2.17117431
82Muscle fiber splitting (HP:0003555)2.15781166
83Hyperbilirubinemia (HP:0002904)2.14424187
84Generalized tonic-clonic seizures (HP:0002069)2.14184715
85Poor eye contact (HP:0000817)2.13833969
86Dialeptic seizures (HP:0011146)2.12784857
87Abnormal EKG (HP:0003115)2.12164613
88Torticollis (HP:0000473)2.10675243
89Arterial tortuosity (HP:0005116)2.09663026
90Mutism (HP:0002300)2.09552347
91Ventricular arrhythmia (HP:0004308)2.09496161
92Neurofibrillary tangles (HP:0002185)2.08925718
93Abnormal gallbladder physiology (HP:0012438)2.08650146
94Cholecystitis (HP:0001082)2.08650146
95Ankle clonus (HP:0011448)2.08438225
96Poikilocytosis (HP:0004447)2.08098154
97Asymmetric septal hypertrophy (HP:0001670)2.07761640
98Cervical subluxation (HP:0003308)2.05296188
99Hyporeflexia of lower limbs (HP:0002600)2.05255767
100Vascular tortuosity (HP:0004948)2.03242900
101Deep venous thrombosis (HP:0002625)2.02935480
102Polycythemia (HP:0001901)2.02345393
103Back pain (HP:0003418)2.02273082
104Polyphagia (HP:0002591)2.01290771
105Myopathic facies (HP:0002058)2.00567733
106Atonic seizures (HP:0010819)1.99909787
107Reticulocytosis (HP:0001923)1.98738452
108Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98703286
109Hypercortisolism (HP:0001578)1.98547978
110Nonprogressive disorder (HP:0003680)1.97036364
111Cholelithiasis (HP:0001081)1.95760704
112Flat acetabular roof (HP:0003180)1.95403709
113Delusions (HP:0000746)1.94666886
114Hand muscle atrophy (HP:0009130)1.94372960
115Aneurysm (HP:0002617)1.94313406
116Disproportionate tall stature (HP:0001519)1.93648412
117Absence seizures (HP:0002121)1.93098741
118Abnormal protein glycosylation (HP:0012346)1.91045703
119Abnormal glycosylation (HP:0012345)1.91045703
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91045703
121Abnormal protein N-linked glycosylation (HP:0012347)1.91045703
122Myocardial infarction (HP:0001658)1.90712854
123Broad face (HP:0000283)1.90556108
124Stridor (HP:0010307)1.89140179
125Difficulty running (HP:0009046)1.88292333
126Wormian bones (HP:0002645)1.88079378
127Menorrhagia (HP:0000132)1.88004484
128Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87924620
129Muscle stiffness (HP:0003552)1.87390881
130Subaortic stenosis (HP:0001682)1.87153931
131Abnormality of the left ventricular outflow tract (HP:0011103)1.87153931
132Epileptic encephalopathy (HP:0200134)1.87038129
133Abnormality of the lower motor neuron (HP:0002366)1.86994540
134Lower limb hyperreflexia (HP:0002395)1.86787297
135Rhabdomyolysis (HP:0003201)1.86737829
136Cortical visual impairment (HP:0100704)1.86595506
137Mitral regurgitation (HP:0001653)1.86161057
138Difficulty climbing stairs (HP:0003551)1.85932807
139Abnormal respiratory epithelium morphology (HP:0012253)1.85602320
140Abnormal respiratory motile cilium morphology (HP:0005938)1.85602320
141Focal dystonia (HP:0004373)1.84559858
142Broad-based gait (HP:0002136)1.83492287
143Hyperammonemia (HP:0001987)1.83296653
144Generalized amyotrophy (HP:0003700)1.82625908
145Joint hemorrhage (HP:0005261)1.80353813
146Ulnar deviation of the wrist (HP:0003049)1.80329169
147Mitral stenosis (HP:0001718)1.79354245
148Annular pancreas (HP:0001734)1.78636081
149Dysdiadochokinesis (HP:0002075)1.78593811
150Abnormal gallbladder morphology (HP:0012437)1.78387849
151Hypercholesterolemia (HP:0003124)1.77850372
152EMG: myopathic abnormalities (HP:0003458)1.77492181
153Foot dorsiflexor weakness (HP:0009027)1.75342299
154Bladder diverticulum (HP:0000015)1.74215698
155Blue sclerae (HP:0000592)1.73662117
156Axonal loss (HP:0003447)1.73111935
157Slender build (HP:0001533)1.71958731
158Long palpebral fissure (HP:0000637)1.71915654
159Easy fatigability (HP:0003388)1.71439662
160Ventricular tachycardia (HP:0004756)1.71095537
161Advanced eruption of teeth (HP:0006288)1.70467114
162Thin bony cortex (HP:0002753)1.68330101
163Bulbar palsy (HP:0001283)1.68081414
164Abnormality of carpal bone ossification (HP:0006257)1.66759663
165Right ventricular cardiomyopathy (HP:0011663)1.65710046
166Diaphragmatic weakness (HP:0009113)1.64611886
167Aortic aneurysm (HP:0004942)1.63071659
168Abnormal ossification of hand bones (HP:0005921)1.62831423
169Purpura (HP:0000979)1.62617035
170Biconcave vertebral bodies (HP:0004586)1.62592843
171Aortic dissection (HP:0002647)1.61746164
172Elbow flexion contracture (HP:0002987)1.60268218
173Dilatation of the ascending aorta (HP:0005111)1.58976734
174Hyperextensible skin (HP:0000974)1.58075838
175Decreased motor nerve conduction velocity (HP:0003431)1.56158545
176Ankle contracture (HP:0006466)1.55628879
177Abnormality of the tricuspid valve (HP:0001702)1.55548133
178Abnormality of the gallbladder (HP:0005264)1.54231502
179Abnormality of the foot musculature (HP:0001436)1.53935853
180Premature skin wrinkling (HP:0100678)1.53111588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK36.97767622
2NLK4.30382294
3TNIK4.10367180
4SIK12.96984832
5SMG12.59352601
6SGK22.41469696
7RIPK12.29687024
8NTRK32.23911512
9PRKD32.22840267
10PDK42.17982562
11PDK32.17982562
12STK382.16862944
13TESK12.10954842
14FGFR42.09266733
15EPHA42.04597843
16PINK12.04539019
17EEF2K1.93641896
18MUSK1.93254231
19SGK2231.89648075
20SGK4941.89648075
21SGK31.86758088
22EIF2AK21.82659998
23CAMKK21.74537048
24RIPK41.74058518
25CDK121.73315755
26PDGFRA1.70639069
27PHKG21.59295275
28PHKG11.59295275
29EPHA21.59277087
30CAMKK11.58952373
31DAPK21.49504221
32MAP3K91.44790842
33MAP2K71.40968586
34ARAF1.36648892
35TAOK11.36119481
36GRK61.32294873
37EPHB11.30161014
38MAP3K121.29802274
39UHMK11.29688741
40CSNK1G11.29578034
41PAK61.24573584
42BMX1.21413166
43TESK21.20567582
44CAMK11.20555828
45DYRK1A1.19497793
46PTK21.17633759
47LATS21.17220940
48MAP2K61.16538326
49FES1.15869000
50PKN21.14807960
51MAP3K31.13942058
52KIT1.13091620
53BCKDK1.12839039
54MST1R1.08419914
55PDK21.03874840
56DDR21.01314634
57DYRK1B1.00099698
58MTOR0.98243543
59PAK40.96094553
60MAP3K60.95558864
61CDC42BPA0.95344108
62MINK10.94539299
63TYRO30.93926989
64MARK10.90151698
65RPS6KA20.88033721
66MAPK110.86900556
67PIM20.86881905
68MAP2K40.86277144
69MAP3K10.86079532
70PTK60.83567764
71TRPM70.77272430
72NME20.76450361
73KSR20.75864854
74LMTK20.73884585
75CDK190.73553572
76PDK10.73174491
77CAMK1D0.71651035
78MET0.71482003
79CAMK40.71459455
80PTK2B0.71308217
81SIK20.68710750
82MAP3K130.66266383
83RET0.66161089
84CASK0.65600192
85STK110.65368569
86ICK0.65093789
87OBSCN0.64061543
88PDPK10.64020306
89PRKG20.63333054
90MAP3K20.60980476
91IRAK20.60858347
92WNK10.59543613
93PRKCG0.59340077
94PRKD20.59311430
95LIMK10.57711367
96JAK20.56252075
97SGK10.55716518
98CDK40.55618210
99KSR10.55376897
100CDK50.55348906
101RAF10.54929657
102TEC0.53665765
103TRIB30.53664688
104TAOK20.53278748
105EPHB20.53192284
106FGFR30.52663079
107NTRK20.52092843
108MAPK40.50812398
109MOS0.50793808
110MAP3K80.49676447
111RPS6KL10.48666611
112RPS6KC10.48666611
113SYK0.48536704
114* PRKAA10.48166545
115DAPK10.48122779
116DMPK0.47819277
117MAPK120.47344213
118CDK150.46306987
119MAP3K110.46244203
120CDK11A0.46232711
121PRPF4B0.44301852
122PAK20.44157393
123BRAF0.43311222
124IRAK30.43157996
125CAMK1G0.43045495
126AKT20.43035418
127DAPK30.42005205
128HIPK20.41717073
129TTN0.41342890
130CAMK2A0.40648745
131CCNB10.40527729
132PIM10.40221898
133ZAP700.39947149
134CDK180.39435625
135MAPK100.39171891
136MAP2K30.38836001
137MAP3K70.38798365
138PRKD10.38773434
139MAP3K50.38627106
140CDK140.38066789
141MAPKAPK30.38053511
142MAP3K100.37866663
143IRAK40.35342210
144GRK50.33075415
145NTRK10.32140840
146PAK10.31142042
147PRKCZ0.30713686
148ERN10.30176891
149JAK10.29027079
150CAMK2G0.28585303
151MAP3K40.27983403
152MAPK130.26398032
153NEK10.24674390
154MARK20.23870633
155PRKACG0.23147973
156AKT30.22282640

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.94167506
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40143235
3Nicotine addiction_Homo sapiens_hsa050332.24319898
4Arginine biosynthesis_Homo sapiens_hsa002202.18465171
5Synaptic vesicle cycle_Homo sapiens_hsa047212.13748716
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13446160
7Nitrogen metabolism_Homo sapiens_hsa009102.13028991
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10268620
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.00273342
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77969416
11Other glycan degradation_Homo sapiens_hsa005111.67469168
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67433770
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.62154150
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.56871492
15Fatty acid degradation_Homo sapiens_hsa000711.53847374
16Sulfur relay system_Homo sapiens_hsa041221.53559098
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.53355116
18Circadian entrainment_Homo sapiens_hsa047131.50300633
19Glycerolipid metabolism_Homo sapiens_hsa005611.47691622
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46227081
21Glutamatergic synapse_Homo sapiens_hsa047241.45605913
22Amphetamine addiction_Homo sapiens_hsa050311.45134344
23Olfactory transduction_Homo sapiens_hsa047401.40379621
24Prion diseases_Homo sapiens_hsa050201.39549186
25Non-small cell lung cancer_Homo sapiens_hsa052231.39367967
26Long-term potentiation_Homo sapiens_hsa047201.38056632
27Notch signaling pathway_Homo sapiens_hsa043301.37009103
28Chronic myeloid leukemia_Homo sapiens_hsa052201.36574626
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36175997
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.35753892
31Bile secretion_Homo sapiens_hsa049761.34631343
32GABAergic synapse_Homo sapiens_hsa047271.32896814
33Glucagon signaling pathway_Homo sapiens_hsa049221.32788684
34VEGF signaling pathway_Homo sapiens_hsa043701.31919055
35ECM-receptor interaction_Homo sapiens_hsa045121.31370749
36Insulin secretion_Homo sapiens_hsa049111.31083208
37PPAR signaling pathway_Homo sapiens_hsa033201.30867921
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28405579
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27394669
40Bladder cancer_Homo sapiens_hsa052191.26850603
41Starch and sucrose metabolism_Homo sapiens_hsa005001.25718837
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23272702
43Salivary secretion_Homo sapiens_hsa049701.21911178
44Focal adhesion_Homo sapiens_hsa045101.21846053
45Pentose phosphate pathway_Homo sapiens_hsa000301.21733259
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21277179
47Endometrial cancer_Homo sapiens_hsa052131.20809655
48Morphine addiction_Homo sapiens_hsa050321.20651035
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20543931
50Glioma_Homo sapiens_hsa052141.20073417
51Regulation of autophagy_Homo sapiens_hsa041401.19724985
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18767782
53Acute myeloid leukemia_Homo sapiens_hsa052211.17575730
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17189619
55Fat digestion and absorption_Homo sapiens_hsa049751.16760663
56Fatty acid metabolism_Homo sapiens_hsa012121.16603954
57Propanoate metabolism_Homo sapiens_hsa006401.16270409
58Calcium signaling pathway_Homo sapiens_hsa040201.15387296
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14605867
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11919294
61Arginine and proline metabolism_Homo sapiens_hsa003301.11129943
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09686498
63Butanoate metabolism_Homo sapiens_hsa006501.08472257
64Fatty acid biosynthesis_Homo sapiens_hsa000611.07126023
65Carbon metabolism_Homo sapiens_hsa012001.07019164
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06360027
67Neurotrophin signaling pathway_Homo sapiens_hsa047221.03602149
68Thyroid cancer_Homo sapiens_hsa052161.02729202
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01167953
70Pancreatic cancer_Homo sapiens_hsa052121.00451823
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99846493
72Vibrio cholerae infection_Homo sapiens_hsa051100.99318348
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99269405
74ErbB signaling pathway_Homo sapiens_hsa040120.98127746
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97262142
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97081649
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96615379
78Vitamin digestion and absorption_Homo sapiens_hsa049770.95951393
79Gastric acid secretion_Homo sapiens_hsa049710.95894389
80ABC transporters_Homo sapiens_hsa020100.95538231
81Renal cell carcinoma_Homo sapiens_hsa052110.92683408
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92366848
83mTOR signaling pathway_Homo sapiens_hsa041500.92112414
84Cardiac muscle contraction_Homo sapiens_hsa042600.91680569
85Endocytosis_Homo sapiens_hsa041440.91284123
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89709796
87Biosynthesis of amino acids_Homo sapiens_hsa012300.89083830
88Fructose and mannose metabolism_Homo sapiens_hsa000510.88732064
89Amoebiasis_Homo sapiens_hsa051460.88461933
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85592043
91Proteoglycans in cancer_Homo sapiens_hsa052050.85568819
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.85244216
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85036040
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84414224
95Estrogen signaling pathway_Homo sapiens_hsa049150.83893185
96Taste transduction_Homo sapiens_hsa047420.83731095
97Complement and coagulation cascades_Homo sapiens_hsa046100.83588403
98Pyruvate metabolism_Homo sapiens_hsa006200.82265566
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.80796056
100Adherens junction_Homo sapiens_hsa045200.79745171
101Peroxisome_Homo sapiens_hsa041460.77308169
102HIF-1 signaling pathway_Homo sapiens_hsa040660.76664845
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76661257
104Phenylalanine metabolism_Homo sapiens_hsa003600.76374440
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.75512416
106Cholinergic synapse_Homo sapiens_hsa047250.74939929
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74311757
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74046380
109Small cell lung cancer_Homo sapiens_hsa052220.74006591
110Insulin signaling pathway_Homo sapiens_hsa049100.73992216
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73761233
112beta-Alanine metabolism_Homo sapiens_hsa004100.73623178
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72203585
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71635794
115Oxytocin signaling pathway_Homo sapiens_hsa049210.70724311
116cAMP signaling pathway_Homo sapiens_hsa040240.70615247
117Collecting duct acid secretion_Homo sapiens_hsa049660.70369769
118Melanogenesis_Homo sapiens_hsa049160.70101488
119Gap junction_Homo sapiens_hsa045400.69843443
120Dopaminergic synapse_Homo sapiens_hsa047280.69596200
121Circadian rhythm_Homo sapiens_hsa047100.69217773
122Tryptophan metabolism_Homo sapiens_hsa003800.69010571
123Choline metabolism in cancer_Homo sapiens_hsa052310.68615491
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67804366
125Insulin resistance_Homo sapiens_hsa049310.66620190
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.65709931
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63961347
128Cocaine addiction_Homo sapiens_hsa050300.60039344
129Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59536262
130Renin secretion_Homo sapiens_hsa049240.58848592
131Type II diabetes mellitus_Homo sapiens_hsa049300.58242644
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57704835
133AMPK signaling pathway_Homo sapiens_hsa041520.57629512
134Galactose metabolism_Homo sapiens_hsa000520.57093489
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.57080931
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56353240
137Axon guidance_Homo sapiens_hsa043600.54824096
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54439228
139Lysosome_Homo sapiens_hsa041420.54121594
140Pancreatic secretion_Homo sapiens_hsa049720.52765407
141Selenocompound metabolism_Homo sapiens_hsa004500.51570197
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.50515334
143Rap1 signaling pathway_Homo sapiens_hsa040150.49998813
144Folate biosynthesis_Homo sapiens_hsa007900.49952382
145GnRH signaling pathway_Homo sapiens_hsa049120.48521954
146Thyroid hormone synthesis_Homo sapiens_hsa049180.46885970
147Protein digestion and absorption_Homo sapiens_hsa049740.46829759
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45276370
149Colorectal cancer_Homo sapiens_hsa052100.44930620
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44357779
151Dilated cardiomyopathy_Homo sapiens_hsa054140.44167987
152N-Glycan biosynthesis_Homo sapiens_hsa005100.43487659
153Drug metabolism - other enzymes_Homo sapiens_hsa009830.42775988
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42754681
155Inositol phosphate metabolism_Homo sapiens_hsa005620.42429730

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