ATIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.55360255
2nuclear pore complex assembly (GO:0051292)5.52249907
3DNA unwinding involved in DNA replication (GO:0006268)5.22615883
4establishment of integrated proviral latency (GO:0075713)5.08381901
5protein localization to kinetochore (GO:0034501)4.94144646
6mitotic nuclear envelope disassembly (GO:0007077)4.48474822
7* folic acid-containing compound biosynthetic process (GO:0009396)4.20708482
8pore complex assembly (GO:0046931)4.19097192
9nuclear envelope disassembly (GO:0051081)4.17579256
10membrane disassembly (GO:0030397)4.17579256
11DNA replication initiation (GO:0006270)4.17503431
12DNA replication-dependent nucleosome organization (GO:0034723)4.11928260
13DNA replication-dependent nucleosome assembly (GO:0006335)4.11928260
14regulation of translational fidelity (GO:0006450)3.94297819
15DNA strand elongation involved in DNA replication (GO:0006271)3.93267498
16heterochromatin organization (GO:0070828)3.90990592
17protein localization to chromosome, centromeric region (GO:0071459)3.88553207
18DNA duplex unwinding (GO:0032508)3.88365203
19DNA geometric change (GO:0032392)3.86416626
20establishment of viral latency (GO:0019043)3.85324409
21formation of translation preinitiation complex (GO:0001731)3.84425611
22nucleobase biosynthetic process (GO:0046112)3.84075090
23L-serine metabolic process (GO:0006563)3.83425120
24mitotic sister chromatid segregation (GO:0000070)3.76781320
25DNA strand elongation (GO:0022616)3.73471254
26sister chromatid segregation (GO:0000819)3.71522151
27regulation of gene silencing by RNA (GO:0060966)3.68747846
28regulation of posttranscriptional gene silencing (GO:0060147)3.68747846
29regulation of gene silencing by miRNA (GO:0060964)3.68747846
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67688485
31tRNA aminoacylation for protein translation (GO:0006418)3.61381902
32* IMP biosynthetic process (GO:0006188)3.61104351
33pre-miRNA processing (GO:0031054)3.59502828
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55427290
35tRNA aminoacylation (GO:0043039)3.53057078
36amino acid activation (GO:0043038)3.53057078
37proteasome assembly (GO:0043248)3.52486970
38mitotic sister chromatid cohesion (GO:0007064)3.51632200
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50759768
40CENP-A containing nucleosome assembly (GO:0034080)3.49985217
41mitotic chromosome condensation (GO:0007076)3.49188480
42telomere maintenance via semi-conservative replication (GO:0032201)3.48807324
43chromatin assembly (GO:0031497)3.47211249
44regulation of translational termination (GO:0006449)3.44203913
45negative regulation of ligase activity (GO:0051352)3.41863713
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41863713
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35432817
48regulation of spindle organization (GO:0090224)3.33903776
49viral mRNA export from host cell nucleus (GO:0046784)3.29260560
50maturation of SSU-rRNA (GO:0030490)3.28675107
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27144467
52ribosome assembly (GO:0042255)3.26049786
53nuclear envelope organization (GO:0006998)3.25572910
54regulation of histone H3-K9 methylation (GO:0051570)3.25316285
55DNA replication checkpoint (GO:0000076)3.24666149
56mitotic metaphase plate congression (GO:0007080)3.24449470
57negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19208560
58mitotic recombination (GO:0006312)3.19150591
59* IMP metabolic process (GO:0046040)3.19107561
60spliceosomal snRNP assembly (GO:0000387)3.18965236
61positive regulation of chromosome segregation (GO:0051984)3.18528406
62non-recombinational repair (GO:0000726)3.17883432
63double-strand break repair via nonhomologous end joining (GO:0006303)3.17883432
64purine nucleobase biosynthetic process (GO:0009113)3.17487129
65ribosomal small subunit assembly (GO:0000028)3.17459880
66ribosomal small subunit biogenesis (GO:0042274)3.16782116
67protein complex localization (GO:0031503)3.16573143
68dosage compensation (GO:0007549)3.15688926
69proline biosynthetic process (GO:0006561)3.14990852
70telomere maintenance via recombination (GO:0000722)3.14512458
71nucleobase-containing small molecule interconversion (GO:0015949)3.13468902
72regulation of mitotic spindle organization (GO:0060236)3.13339036
73ribosome biogenesis (GO:0042254)3.11028689
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09273605
75histone arginine methylation (GO:0034969)3.08065504
76rRNA modification (GO:0000154)3.07838274
77RNA stabilization (GO:0043489)3.05910764
78mRNA stabilization (GO:0048255)3.05910764
79DNA ligation (GO:0006266)3.05273073
80translational termination (GO:0006415)3.03863302
81viral transcription (GO:0019083)3.03814478
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.03236343
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03236343
84negative regulation of histone methylation (GO:0031061)3.02450312
85DNA conformation change (GO:0071103)3.02273565
86regulation of mitochondrial translation (GO:0070129)3.02012985
87serine family amino acid biosynthetic process (GO:0009070)2.99423096
88spliceosomal tri-snRNP complex assembly (GO:0000244)2.98608342
89negative regulation of RNA splicing (GO:0033119)2.97431515
90telomere maintenance via telomere lengthening (GO:0010833)2.97246984
91DNA strand renaturation (GO:0000733)2.96459037
92negative regulation of chromosome segregation (GO:0051985)2.96164797
93chromatin assembly or disassembly (GO:0006333)2.95631876
94transcription from mitochondrial promoter (GO:0006390)2.95355703
95G1/S transition of mitotic cell cycle (GO:0000082)2.93544591
96cell cycle G1/S phase transition (GO:0044843)2.93544591
97ribosomal large subunit biogenesis (GO:0042273)2.93404939
98establishment of chromosome localization (GO:0051303)2.93070298
99rRNA metabolic process (GO:0016072)2.92901215
100base-excision repair (GO:0006284)2.92651227
101translational initiation (GO:0006413)2.92492902
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92423511
103peptidyl-arginine omega-N-methylation (GO:0035247)2.91947116
104regulation of cellular amino acid metabolic process (GO:0006521)2.91461043
105signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90362991
106signal transduction involved in DNA damage checkpoint (GO:0072422)2.90362991
107maturation of 5.8S rRNA (GO:0000460)2.90332894
108pseudouridine synthesis (GO:0001522)2.89939367
109DNA topological change (GO:0006265)2.89920584
110negative regulation of mitotic sister chromatid separation (GO:2000816)2.89539634
111negative regulation of sister chromatid segregation (GO:0033046)2.89539634
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89539634
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89539634
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89539634
115histone exchange (GO:0043486)2.88878343
116spindle checkpoint (GO:0031577)2.88717616
117ribonucleoprotein complex biogenesis (GO:0022613)2.88674392
118signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88460055
119signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88460055
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88460055
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87193609
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86867633
123metaphase plate congression (GO:0051310)2.86066848
124translational elongation (GO:0006414)2.84935856
125regulation of RNA export from nucleus (GO:0046831)2.84545648
126protein localization to chromosome (GO:0034502)2.83283339
127regulation of sister chromatid cohesion (GO:0007063)2.82007819
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.81956827
129kinetochore organization (GO:0051383)2.80498255
130negative regulation of mRNA processing (GO:0050686)2.80162809
131translesion synthesis (GO:0019985)2.79701330
132histone H2A monoubiquitination (GO:0035518)2.78814003
133mRNA transport (GO:0051028)2.77224649
134positive regulation of SMAD protein import into nucleus (GO:0060391)2.75876168
135negative regulation of mRNA metabolic process (GO:1903312)2.72320104
136chromatin remodeling at centromere (GO:0031055)2.69881794
137positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.69826495
138positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.69826495
139positive regulation of mitotic sister chromatid separation (GO:1901970)2.69826495
140regulation of chromosome segregation (GO:0051983)2.68653471
141postreplication repair (GO:0006301)2.68327210
142regulation of centrosome cycle (GO:0046605)2.67384808
143regulation of gene silencing (GO:0060968)2.66929251
144DNA replication-independent nucleosome assembly (GO:0006336)2.64635735
145DNA replication-independent nucleosome organization (GO:0034724)2.64635735
1463-UTR-mediated mRNA stabilization (GO:0070935)2.64452613
147RNA splicing, via transesterification reactions (GO:0000375)2.64150149
148RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.63657497
149mRNA splicing, via spliceosome (GO:0000398)2.63657497
150meiotic chromosome segregation (GO:0045132)2.63569450
151attachment of spindle microtubules to kinetochore (GO:0008608)2.63128722
152rRNA processing (GO:0006364)2.62646249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.56391729
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.59486134
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.87657639
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65776192
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31894936
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.18766263
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98632638
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91264979
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50562925
10MYC_22102868_ChIP-Seq_BL_Human2.48718671
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19208318
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16188607
13AR_21909140_ChIP-Seq_LNCAP_Human2.14177331
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13377859
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.08706093
16XRN2_22483619_ChIP-Seq_HELA_Human2.03191540
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89963369
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.84669297
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83774794
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81762125
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81084711
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77787535
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.72376288
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71979286
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69024502
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68913180
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68085928
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65335466
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.56815091
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56227542
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55228710
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55101362
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54396142
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50310531
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.50184226
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50026975
37VDR_23849224_ChIP-Seq_CD4+_Human1.49424405
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48311573
39FOXP3_21729870_ChIP-Seq_TREG_Human1.47362749
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45732836
41TTF2_22483619_ChIP-Seq_HELA_Human1.45062502
42KDM5A_27292631_Chip-Seq_BREAST_Human1.44783411
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43042435
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42878283
45CIITA_25753668_ChIP-Seq_RAJI_Human1.42625760
46DCP1A_22483619_ChIP-Seq_HELA_Human1.41927133
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.41294001
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39671442
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39246545
50VDR_21846776_ChIP-Seq_THP-1_Human1.38618516
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.38537320
52* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36689687
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36135595
54ZNF263_19887448_ChIP-Seq_K562_Human1.35406086
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35198752
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34914575
57ELK1_19687146_ChIP-ChIP_HELA_Human1.34444079
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34433957
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29790557
60* GABP_19822575_ChIP-Seq_HepG2_Human1.29785944
61TFEB_21752829_ChIP-Seq_HELA_Human1.27955506
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26966517
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26963623
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25526892
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25526892
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25526892
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23830589
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22172770
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22113825
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19930407
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19020102
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.18219655
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17986531
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17768173
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15048375
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12738898
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12401651
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12115585
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11288538
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10802592
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08125182
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07819204
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07069654
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07059669
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06738260
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06295773
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.06185279
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06007866
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05434123
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05094723
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04824260
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04373321
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02515906
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99009628
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.98087886
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98000180
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97980216
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97035238
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.96749385
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96417702
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96078962
102TCF7_22412390_ChIP-Seq_EML_Mouse0.95720049
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93204998
104UTX_26944678_Chip-Seq_JUKART_Human0.92895802
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91898460
106CHD1_26751641_Chip-Seq_LNCaP_Human0.91432288
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91358262
108* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90769852
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90618779
110TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89924345
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89865007
112MAF_26560356_Chip-Seq_TH1_Human0.89840892
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89683201
114* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89557450
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88094889
116ATF3_27146783_Chip-Seq_COLON_Human0.87778907
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87482216
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.86906652
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85605242
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85171730
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85007172
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84871297
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84867533
124* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84791726
125MYC_18940864_ChIP-ChIP_HL60_Human0.81420786
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80940191
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.80823958
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79504492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.69899867
2MP0003693_abnormal_embryo_hatching3.62799134
3MP0003111_abnormal_nucleus_morphology3.56856180
4MP0004957_abnormal_blastocyst_morpholog3.55388814
5MP0010352_gastrointestinal_tract_polyps3.48327910
6MP0008057_abnormal_DNA_replication3.22219963
7MP0003077_abnormal_cell_cycle3.15899023
8MP0003705_abnormal_hypodermis_morpholog2.68555019
9MP0010307_abnormal_tumor_latency2.38361638
10MP0001730_embryonic_growth_arrest2.36474908
11MP0008007_abnormal_cellular_replicative2.32161602
12MP0005076_abnormal_cell_differentiation2.29623392
13MP0002396_abnormal_hematopoietic_system2.21849048
14MP0000350_abnormal_cell_proliferation2.21638515
15MP0003123_paternal_imprinting2.17296763
16MP0008058_abnormal_DNA_repair2.09466041
17MP0008932_abnormal_embryonic_tissue2.00623084
18MP0003718_maternal_effect1.99045717
19MP0004197_abnormal_fetal_growth/weight/1.88788073
20MP0001672_abnormal_embryogenesis/_devel1.87383529
21MP0005380_embryogenesis_phenotype1.87383529
22MP0009697_abnormal_copulation1.83391905
23MP0003984_embryonic_growth_retardation1.75869646
24MP0003566_abnormal_cell_adhesion1.75652032
25MP0002088_abnormal_embryonic_growth/wei1.73769024
26MP0001697_abnormal_embryo_size1.73381939
27MP0002086_abnormal_extraembryonic_tissu1.72126576
28MP0002084_abnormal_developmental_patter1.71203771
29MP0004808_abnormal_hematopoietic_stem1.69855043
30MP0006035_abnormal_mitochondrial_morpho1.66722034
31MP0002085_abnormal_embryonic_tissue1.63421019
32MP0002796_impaired_skin_barrier1.59575705
33MP0002080_prenatal_lethality1.58972808
34MP0000490_abnormal_crypts_of1.55278748
35MP0000537_abnormal_urethra_morphology1.54572057
36MP0010030_abnormal_orbit_morphology1.53962330
37MP0002877_abnormal_melanocyte_morpholog1.53856101
38MP0003186_abnormal_redox_activity1.45038882
39MP0009053_abnormal_anal_canal1.43728459
40MP0005023_abnormal_wound_healing1.42093530
41MP0006036_abnormal_mitochondrial_physio1.39762112
42MP0005451_abnormal_body_composition1.38975999
43MP0003890_abnormal_embryonic-extraembry1.38580888
44MP0003786_premature_aging1.35156928
45MP0005408_hypopigmentation1.34251276
46MP0003567_abnormal_fetal_cardiomyocyte1.30721210
47MP0001661_extended_life_span1.30717776
48MP0002019_abnormal_tumor_incidence1.28967463
49MP0003121_genomic_imprinting1.26949462
50MP0002254_reproductive_system_inflammat1.25304612
51MP0001346_abnormal_lacrimal_gland1.25259016
52MP0001881_abnormal_mammary_gland1.24941422
53MP0000313_abnormal_cell_death1.22776657
54MP0008438_abnormal_cutaneous_collagen1.20967411
55MP0010234_abnormal_vibrissa_follicle1.20880143
56MP0003315_abnormal_perineum_morphology1.20490000
57MP0006054_spinal_hemorrhage1.18876577
58MP0000733_abnormal_muscle_development1.14191756
59MP0001293_anophthalmia1.13301797
60MP0001915_intracranial_hemorrhage1.10394140
61MP0009278_abnormal_bone_marrow1.10359617
62MP0002938_white_spotting1.07588534
63MP0001849_ear_inflammation1.07547754
64MP0000703_abnormal_thymus_morphology1.07503559
65MP0000858_altered_metastatic_potential1.03809971
66MP0009333_abnormal_splenocyte_physiolog1.03395937
67MP0005397_hematopoietic_system_phenotyp1.03064071
68MP0001545_abnormal_hematopoietic_system1.03064071
69MP0000428_abnormal_craniofacial_morphol0.98984746
70MP0008877_abnormal_DNA_methylation0.98723203
71MP0009672_abnormal_birth_weight0.98440199
72MP0002111_abnormal_tail_morphology0.96909780
73MP0009703_decreased_birth_body0.95568983
74MP0003119_abnormal_digestive_system0.94349063
75MP0002398_abnormal_bone_marrow0.93487701
76MP0003941_abnormal_skin_development0.93396051
77MP0003763_abnormal_thymus_physiology0.92510095
78MP0002722_abnormal_immune_system0.91972776
79MP0006292_abnormal_olfactory_placode0.90694767
80MP0002092_abnormal_eye_morphology0.90249530
81MP0004264_abnormal_extraembryonic_tissu0.89155864
82MP0003300_gastrointestinal_ulcer0.88169107
83MP0003806_abnormal_nucleotide_metabolis0.88006553
84MP0002163_abnormal_gland_morphology0.87950836
85MP0003937_abnormal_limbs/digits/tail_de0.86010075
86MP0001853_heart_inflammation0.84645926
87MP0000689_abnormal_spleen_morphology0.84457214
88MP0002925_abnormal_cardiovascular_devel0.83869242
89MP0005621_abnormal_cell_physiology0.81903427
90MP0002697_abnormal_eye_size0.81633504
91MP0005623_abnormal_meninges_morphology0.80255294
92MP0004185_abnormal_adipocyte_glucose0.78399976
93MP0005384_cellular_phenotype0.77596302
94MP0003091_abnormal_cell_migration0.76609448
95MP0000477_abnormal_intestine_morphology0.76251672
96MP0003115_abnormal_respiratory_system0.76152827
97MP0000432_abnormal_head_morphology0.76041741
98MP0005075_abnormal_melanosome_morpholog0.75261990
99MP0001929_abnormal_gametogenesis0.73709587
100MP0000678_abnormal_parathyroid_gland0.73495369
101MP0008260_abnormal_autophagy0.73086643
102MP0000579_abnormal_nail_morphology0.72753698
103MP0003448_altered_tumor_morphology0.72034347
104MP0008770_decreased_survivor_rate0.71718340
105MP0002060_abnormal_skin_morphology0.71195221
106MP0000566_synostosis0.70799645
107MP0000372_irregular_coat_pigmentation0.69852560
108MP0002429_abnormal_blood_cell0.69159486
109MP0003935_abnormal_craniofacial_develop0.67931430
110MP0003303_peritoneal_inflammation0.67316541
111MP0003221_abnormal_cardiomyocyte_apopto0.67211200
112MP0000358_abnormal_cell_content/0.66972133
113MP0004782_abnormal_surfactant_physiolog0.66620387
114MP0005501_abnormal_skin_physiology0.66070501
115MP0004233_abnormal_muscle_weight0.65634057
116MP0001286_abnormal_eye_development0.64733355
117MP0000653_abnormal_sex_gland0.64147140
118MP0003279_aneurysm0.64119934
119MP0001529_abnormal_vocalization0.63173535
120MP0001727_abnormal_embryo_implantation0.62990141
121MP0000371_diluted_coat_color0.62174652
122MP0003453_abnormal_keratinocyte_physiol0.61870126
123MP0001348_abnormal_lacrimal_gland0.60707478
124MP0000266_abnormal_heart_morphology0.60263301
125MP0005367_renal/urinary_system_phenotyp0.59299466
126MP0000516_abnormal_urinary_system0.59299466
127MP0000627_abnormal_mammary_gland0.59066839
128MP0001243_abnormal_dermal_layer0.58816101
129MP0002160_abnormal_reproductive_system0.58482476
130MP0002210_abnormal_sex_determination0.57497804
131MP0001145_abnormal_male_reproductive0.57222717
132MP0003943_abnormal_hepatobiliary_system0.56492523
133MP0003936_abnormal_reproductive_system0.56331646
134MP0003699_abnormal_female_reproductive0.56120606
135MP0002269_muscular_atrophy0.55929576
136MP0001216_abnormal_epidermal_layer0.55868759
137MP0002006_tumorigenesis0.55380747
138MP0005379_endocrine/exocrine_gland_phen0.53324668

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.14043401
2Increased serum pyruvate (HP:0003542)3.74825574
3Microvesicular hepatic steatosis (HP:0001414)3.74238013
4Ependymoma (HP:0002888)3.70732708
5Selective tooth agenesis (HP:0001592)3.59683682
6Abnormal gallbladder physiology (HP:0012438)3.16848231
7Cholecystitis (HP:0001082)3.16848231
8Progressive muscle weakness (HP:0003323)3.02882719
9Chromsome breakage (HP:0040012)2.92097829
10Deviation of the thumb (HP:0009603)2.88235887
11Medulloblastoma (HP:0002885)2.88125143
12Colon cancer (HP:0003003)2.77989143
13Astrocytoma (HP:0009592)2.77969864
14Abnormality of the astrocytes (HP:0100707)2.77969864
15Proximal placement of thumb (HP:0009623)2.71720813
16Nephroblastoma (Wilms tumor) (HP:0002667)2.70267420
17Reticulocytopenia (HP:0001896)2.65586831
18Progressive external ophthalmoplegia (HP:0000590)2.65514070
19Rhabdomyosarcoma (HP:0002859)2.62441229
20Short 4th metacarpal (HP:0010044)2.61224391
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61224391
22Increased nuchal translucency (HP:0010880)2.56672663
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56661262
24Basal cell carcinoma (HP:0002671)2.55787286
25Missing ribs (HP:0000921)2.55768472
26Abnormality of cells of the erythroid lineage (HP:0012130)2.55485769
27Cutaneous melanoma (HP:0012056)2.51483336
28Abnormality of methionine metabolism (HP:0010901)2.50792652
29Birth length less than 3rd percentile (HP:0003561)2.50480935
30Embryonal renal neoplasm (HP:0011794)2.49027681
31Agnosia (HP:0010524)2.46683472
32Horseshoe kidney (HP:0000085)2.45857730
33Macrocytic anemia (HP:0001972)2.45828388
34Type I transferrin isoform profile (HP:0003642)2.44888549
35Acute encephalopathy (HP:0006846)2.44523973
36Protrusio acetabuli (HP:0003179)2.43444711
37Abnormal number of erythroid precursors (HP:0012131)2.42632875
38Abnormality of chromosome stability (HP:0003220)2.40228789
39Increased density of long bones (HP:0006392)2.38629593
40Abnormality of the calcaneus (HP:0008364)2.34857156
41Abnormality of the anterior horn cell (HP:0006802)2.27494140
42Degeneration of anterior horn cells (HP:0002398)2.27494140
43Premature ovarian failure (HP:0008209)2.27202013
44Volvulus (HP:0002580)2.26257688
45Abnormality of the umbilical cord (HP:0010881)2.24580699
46Reduced antithrombin III activity (HP:0001976)2.23647467
47Glioma (HP:0009733)2.23344075
4811 pairs of ribs (HP:0000878)2.23339387
49Rough bone trabeculation (HP:0100670)2.19915577
50Neoplasm of striated muscle (HP:0009728)2.17302310
51Cerebral hypomyelination (HP:0006808)2.16700993
52Myelodysplasia (HP:0002863)2.14735106
53Increased serum lactate (HP:0002151)2.14647727
54Increased hepatocellular lipid droplets (HP:0006565)2.14117357
55Secondary amenorrhea (HP:0000869)2.12456897
56Meckel diverticulum (HP:0002245)2.12290711
57Acute necrotizing encephalopathy (HP:0006965)2.11797000
58Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10919224
59Abnormal number of incisors (HP:0011064)2.10895498
60Aplasia/hypoplasia of the humerus (HP:0006507)2.09869523
61Squamous cell carcinoma (HP:0002860)2.09698734
62Gastrointestinal carcinoma (HP:0002672)2.08866059
63Malignant gastrointestinal tract tumors (HP:0006749)2.08866059
64Biliary tract neoplasm (HP:0100574)2.08695177
65Abnormal mitochondria in muscle tissue (HP:0008316)2.07647631
66Testicular atrophy (HP:0000029)2.07223720
67Pancytopenia (HP:0001876)2.07202534
68Gout (HP:0001997)2.06578744
69Abnormality of cochlea (HP:0000375)2.05946474
70Short humerus (HP:0005792)2.05919151
71High pitched voice (HP:0001620)2.05649687
72Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04327959
73Hyperglycinuria (HP:0003108)2.02932569
74Abnormality of the ileum (HP:0001549)2.02666985
75Atresia of the external auditory canal (HP:0000413)2.02190689
76Pseudobulbar signs (HP:0002200)2.01937474
77Trismus (HP:0000211)2.00711240
78Absent thumb (HP:0009777)1.99806339
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.99679160
80Patellar aplasia (HP:0006443)1.99533562
81Amaurosis fugax (HP:0100576)1.98661459
82Choanal atresia (HP:0000453)1.98558071
83Microglossia (HP:0000171)1.98516842
84Abnormality of reticulocytes (HP:0004312)1.97631980
85Aplastic anemia (HP:0001915)1.96776774
86Increased CSF lactate (HP:0002490)1.96668525
87Ectopic kidney (HP:0000086)1.95985935
88Thrombocytosis (HP:0001894)1.94855857
89Cafe-au-lait spot (HP:0000957)1.94067129
90Lipid accumulation in hepatocytes (HP:0006561)1.93454830
91Neoplasm of the oral cavity (HP:0100649)1.93091404
92Ankle contracture (HP:0006466)1.93012470
93Septate vagina (HP:0001153)1.92587162
94Abnormality of serine family amino acid metabolism (HP:0010894)1.92444228
95Abnormality of glycine metabolism (HP:0010895)1.92444228
96Neoplasm of the pancreas (HP:0002894)1.92247159
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91542680
98Abnormal protein N-linked glycosylation (HP:0012347)1.91542680
99Abnormal protein glycosylation (HP:0012346)1.91542680
100Abnormal glycosylation (HP:0012345)1.91542680
101Prominent nose (HP:0000448)1.90602288
102Absent radius (HP:0003974)1.90301620
103Hyperacusis (HP:0010780)1.90265617
104Abnormality of the duodenum (HP:0002246)1.89381707
105Cerebral edema (HP:0002181)1.89288334
106Abnormal umbilical cord blood vessels (HP:0011403)1.88727232
107Single umbilical artery (HP:0001195)1.88727232
108Abnormality of the fetal cardiovascular system (HP:0010948)1.88727232
109Pallor (HP:0000980)1.88705440
110Multiple enchondromatosis (HP:0005701)1.88611647
111Facial cleft (HP:0002006)1.88186121
112Renal duplication (HP:0000075)1.88178558
113Adenoma sebaceum (HP:0009720)1.87673946
114Angiofibromas (HP:0010615)1.87673946
115Abnormality of the preputium (HP:0100587)1.87489450
116Sparse eyelashes (HP:0000653)1.86344830
117Cortical dysplasia (HP:0002539)1.85910185
118Skin tags (HP:0010609)1.85616652
119Abnormality of the 4th metacarpal (HP:0010012)1.85246200
120Aplasia/Hypoplasia of the patella (HP:0006498)1.84828576
121Duodenal stenosis (HP:0100867)1.84508949
122Small intestinal stenosis (HP:0012848)1.84508949
123Ulnar bowing (HP:0003031)1.83568098
124Triphalangeal thumb (HP:0001199)1.83288804
125Breast hypoplasia (HP:0003187)1.83008384
126Pancreatic islet-cell hyperplasia (HP:0004510)1.82865661
127Megaloblastic anemia (HP:0001889)1.82810293
128Abnormalities of placenta or umbilical cord (HP:0001194)1.81429820
129Abnormal platelet volume (HP:0011876)1.80220838
130Increased mean platelet volume (HP:0011877)1.78816725
131Shallow orbits (HP:0000586)1.78323296
132Long eyelashes (HP:0000527)1.77562047
133Preauricular skin tag (HP:0000384)1.77479360
134Impulsivity (HP:0100710)1.77322241
135Cerebral aneurysm (HP:0004944)1.76892296
136Abnormality of serum amino acid levels (HP:0003112)1.75706238
137Premature rupture of membranes (HP:0001788)1.74866065
138Bowel diverticulosis (HP:0005222)1.74465200
139Postnatal microcephaly (HP:0005484)1.74408101
140Absent forearm bone (HP:0003953)1.74190558
141Aplasia involving forearm bones (HP:0009822)1.74190558
142Oral leukoplakia (HP:0002745)1.73852730
143Neoplasm of the adrenal gland (HP:0100631)1.73628638
144Cleft eyelid (HP:0000625)1.73008996
145Abnormality of the carotid arteries (HP:0005344)1.72875963
146Ragged-red muscle fibers (HP:0003200)1.72841550
147Freckling (HP:0001480)1.71553856
148Sandal gap (HP:0001852)1.70312195
149Skull defect (HP:0001362)1.70216141
150Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70157972
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.69978825
152Genu recurvatum (HP:0002816)1.69347922
153Uterine neoplasm (HP:0010784)1.69141833
154Exercise intolerance (HP:0003546)1.68957154
155Ovarian neoplasm (HP:0100615)1.68422371
156Sloping forehead (HP:0000340)1.67573464
157Fused cervical vertebrae (HP:0002949)1.67390694
158Spastic diplegia (HP:0001264)1.67360032
159Rectal prolapse (HP:0002035)1.66413720
160Tracheoesophageal fistula (HP:0002575)1.65769916
161Deep philtrum (HP:0002002)1.64786893
162Pelvic girdle muscle weakness (HP:0003749)1.64277552
163Slender long bone (HP:0003100)1.63527701
164Metaphyseal cupping (HP:0003021)1.63189102
165Abnormal lung lobation (HP:0002101)1.63055580
166Rib fusion (HP:0000902)1.62638702
167Spinal muscular atrophy (HP:0007269)1.62062062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.22233776
2CDC73.74773393
3EEF2K3.73328176
4CDK123.49984123
5SMG13.06573694
6PKN22.88398819
7WEE12.71383077
8PBK2.68306726
9NEK22.31505857
10BUB12.29210784
11PASK2.26016741
12RPS6KB22.25335438
13TSSK62.24220775
14MAP3K102.12866029
15TTK2.04771636
16TAF12.02742537
17TRIB32.01821028
18STK101.97925704
19NEK11.93522025
20EPHA21.91505442
21NME11.77034796
22EIF2AK11.70939385
23MST41.70633158
24CDK71.61635340
25CDK41.58688085
26SCYL21.58375707
27TTN1.55996231
28SRPK11.54267761
29MAP3K81.54266273
30ATR1.47887480
31TGFBR11.47788845
32STK161.43161512
33PLK11.43144998
34PAK41.41902419
35MKNK11.39308773
36FLT31.35421028
37AURKB1.35300627
38LRRK21.34132199
39TLK11.32923199
40TESK21.32246217
41CHEK11.29228534
42CDK61.25203023
43NME21.23993971
44RPS6KA41.23879810
45EIF2AK21.12786190
46BRSK21.12007265
47PLK31.11538375
48MAP4K11.10697347
49MTOR1.08562379
50STK31.08335736
51BRD41.07686114
52ACVR1B1.06842873
53PIM11.05822095
54BMX1.05096592
55STK41.03828813
56CHEK21.00977804
57PTK60.99937583
58LATS10.97703411
59ATM0.96092132
60TRIM280.95978969
61DAPK10.94181473
62NUAK10.93587324
63MKNK20.92471648
64* ALK0.90352722
65CDK20.90319843
66PAK20.89554379
67PDGFRA0.86185530
68GRK60.85773014
69IRAK30.81646059
70CDK80.81405440
71MAP2K30.81305636
72PLK40.76349488
73AURKA0.74194076
74BCKDK0.73504992
75LATS20.72468327
76MELK0.71223156
77FGFR40.70011704
78ZAK0.66925977
79EIF2AK30.66423026
80PDK20.66075658
81JAK30.63647255
82FGFR10.61712644
83TESK10.61606597
84CDK10.59844092
85NEK90.59225702
86CSNK2A20.57504417
87CLK10.55514620
88AKT20.55417530
89DYRK30.55276938
90PAK10.54491545
91ERN10.52410236
92DDR20.51027088
93BTK0.50968188
94MST1R0.49913880
95CSF1R0.49565867
96MAPKAPK50.49525941
97VRK10.49250303
98ERBB40.48554404
99CSNK1E0.47358222
100BRAF0.46498383
101SIK30.46364837
102ICK0.45790099
103MAPKAPK30.45330167
104TAOK20.44903841
105RIPK10.44347337
106PRKDC0.43855586
107SIK10.43163653
108BRSK10.43008733
109CSNK1D0.42871838
110TRPM70.42335574
111CDK90.40729831
112MET0.38616148
113MAPK140.37199370
114CSNK2A10.35465149
115ILK0.35391670
116RPS6KC10.34455481
117RPS6KL10.34455481
118MAP3K90.33389587
119PRKCI0.33183289
120MAPK10.33125237
121AKT10.32721212
122CDK11A0.32166240
123CHUK0.32144913
124KDR0.31585816
125ZAP700.31472177
126CCNB10.30926606
127CDK180.29438047
128CSNK1G30.27860024
129CDK150.27821526
130CDK140.27701258
131CSNK1G10.24742646
132RAF10.22593143

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29495638
2Mismatch repair_Homo sapiens_hsa034303.72564558
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44744101
4RNA transport_Homo sapiens_hsa030133.10374409
5* One carbon pool by folate_Homo sapiens_hsa006702.97327820
6Spliceosome_Homo sapiens_hsa030402.90922829
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85193190
8Cell cycle_Homo sapiens_hsa041102.66129199
9Base excision repair_Homo sapiens_hsa034102.59864273
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54958101
11Nucleotide excision repair_Homo sapiens_hsa034202.38015552
12Homologous recombination_Homo sapiens_hsa034402.29296610
13Ribosome_Homo sapiens_hsa030102.22091358
14mRNA surveillance pathway_Homo sapiens_hsa030151.95826576
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.82564045
16Non-homologous end-joining_Homo sapiens_hsa034501.79974020
17Fanconi anemia pathway_Homo sapiens_hsa034601.78829134
18RNA polymerase_Homo sapiens_hsa030201.73060380
19p53 signaling pathway_Homo sapiens_hsa041151.68405575
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65953140
21RNA degradation_Homo sapiens_hsa030181.62556679
22Systemic lupus erythematosus_Homo sapiens_hsa053221.61370802
23Pyruvate metabolism_Homo sapiens_hsa006201.59965074
24Vitamin B6 metabolism_Homo sapiens_hsa007501.55289288
25Viral carcinogenesis_Homo sapiens_hsa052031.51940882
26Pyrimidine metabolism_Homo sapiens_hsa002401.50551329
27Antigen processing and presentation_Homo sapiens_hsa046121.31468296
28Protein export_Homo sapiens_hsa030601.30788830
29Fatty acid elongation_Homo sapiens_hsa000621.28491763
30MicroRNAs in cancer_Homo sapiens_hsa052061.28167056
31Proteasome_Homo sapiens_hsa030501.22978250
32Propanoate metabolism_Homo sapiens_hsa006401.20554735
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19251067
34Small cell lung cancer_Homo sapiens_hsa052221.16739333
35HTLV-I infection_Homo sapiens_hsa051661.12341152
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11156866
37Chronic myeloid leukemia_Homo sapiens_hsa052201.10346636
38Epstein-Barr virus infection_Homo sapiens_hsa051691.09732858
39Biosynthesis of amino acids_Homo sapiens_hsa012301.09613790
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09606748
41Thyroid cancer_Homo sapiens_hsa052161.07672177
42Selenocompound metabolism_Homo sapiens_hsa004501.07538854
43Herpes simplex infection_Homo sapiens_hsa051681.05323680
44Steroid biosynthesis_Homo sapiens_hsa001001.03953583
45Basal transcription factors_Homo sapiens_hsa030221.00840943
46Parkinsons disease_Homo sapiens_hsa050120.99091008
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.92640797
48Adherens junction_Homo sapiens_hsa045200.92336856
49Glutathione metabolism_Homo sapiens_hsa004800.90662704
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.90651484
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90280185
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90128595
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90015235
54Legionellosis_Homo sapiens_hsa051340.89931729
55Bladder cancer_Homo sapiens_hsa052190.88649759
56Folate biosynthesis_Homo sapiens_hsa007900.88609554
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86118486
58Fructose and mannose metabolism_Homo sapiens_hsa000510.85669524
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85382304
60Hippo signaling pathway_Homo sapiens_hsa043900.84778005
61Huntingtons disease_Homo sapiens_hsa050160.84743893
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84422635
63Oxidative phosphorylation_Homo sapiens_hsa001900.83530493
64Apoptosis_Homo sapiens_hsa042100.82388009
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81469235
66Colorectal cancer_Homo sapiens_hsa052100.79337725
67Viral myocarditis_Homo sapiens_hsa054160.78371268
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77862828
69TGF-beta signaling pathway_Homo sapiens_hsa043500.77616494
70Proteoglycans in cancer_Homo sapiens_hsa052050.77095743
71Lysine degradation_Homo sapiens_hsa003100.76189706
72mTOR signaling pathway_Homo sapiens_hsa041500.76169502
73Basal cell carcinoma_Homo sapiens_hsa052170.75362560
74Acute myeloid leukemia_Homo sapiens_hsa052210.68771712
75Hepatitis B_Homo sapiens_hsa051610.68182876
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68078374
77Notch signaling pathway_Homo sapiens_hsa043300.67147985
78Oocyte meiosis_Homo sapiens_hsa041140.65969393
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65332545
80Pentose phosphate pathway_Homo sapiens_hsa000300.64398283
81Arginine and proline metabolism_Homo sapiens_hsa003300.63273511
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63185243
83Non-small cell lung cancer_Homo sapiens_hsa052230.62472149
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.61933271
85Measles_Homo sapiens_hsa051620.60988142
86HIF-1 signaling pathway_Homo sapiens_hsa040660.59656873
87Shigellosis_Homo sapiens_hsa051310.59642439
88Fatty acid metabolism_Homo sapiens_hsa012120.59423421
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.57876127
90Primary immunodeficiency_Homo sapiens_hsa053400.57822803
91Prostate cancer_Homo sapiens_hsa052150.57295585
92Pancreatic cancer_Homo sapiens_hsa052120.55943850
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.55719615
94Focal adhesion_Homo sapiens_hsa045100.55416790
95Pathways in cancer_Homo sapiens_hsa052000.54161333
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.53953552
97* Metabolic pathways_Homo sapiens_hsa011000.51539538
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51527731
99Alcoholism_Homo sapiens_hsa050340.51347663
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51172058
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49660721
102Carbon metabolism_Homo sapiens_hsa012000.48434573
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47821649
104Endometrial cancer_Homo sapiens_hsa052130.47389213
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46510286
106* Purine metabolism_Homo sapiens_hsa002300.44106908
107Arginine biosynthesis_Homo sapiens_hsa002200.43626344
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41447018
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40657423
110B cell receptor signaling pathway_Homo sapiens_hsa046620.39877874
111Toxoplasmosis_Homo sapiens_hsa051450.38701258
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38693426
113ECM-receptor interaction_Homo sapiens_hsa045120.38670250
114Alzheimers disease_Homo sapiens_hsa050100.38037822
115Melanoma_Homo sapiens_hsa052180.37953354
116Influenza A_Homo sapiens_hsa051640.37179146
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36875123
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36753217
119Leishmaniasis_Homo sapiens_hsa051400.36747142
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36440547
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34457839
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34162162
123Hedgehog signaling pathway_Homo sapiens_hsa043400.33982924
124Phenylalanine metabolism_Homo sapiens_hsa003600.33920488
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33863796
126Tight junction_Homo sapiens_hsa045300.33661403
127N-Glycan biosynthesis_Homo sapiens_hsa005100.33075709
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33001449
129Hematopoietic cell lineage_Homo sapiens_hsa046400.31707205
130Sulfur relay system_Homo sapiens_hsa041220.31702860
131Galactose metabolism_Homo sapiens_hsa000520.31671711
132Vitamin digestion and absorption_Homo sapiens_hsa049770.30833109
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28814542
134Tyrosine metabolism_Homo sapiens_hsa003500.25648654
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24858012
136Fatty acid degradation_Homo sapiens_hsa000710.23196419
137Sulfur metabolism_Homo sapiens_hsa009200.19431482
138beta-Alanine metabolism_Homo sapiens_hsa004100.15119555
139Wnt signaling pathway_Homo sapiens_hsa043100.13539680
140Peroxisome_Homo sapiens_hsa041460.12198265
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09994028
142Starch and sucrose metabolism_Homo sapiens_hsa005000.08166236

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