ATL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.03534456
2hemidesmosome assembly (GO:0031581)4.63467536
3low-density lipoprotein particle clearance (GO:0034383)4.45572149
4regulation of integrin-mediated signaling pathway (GO:2001044)4.35836296
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.29918091
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.27836811
7L-phenylalanine catabolic process (GO:0006559)4.27836811
8positive regulation of fatty acid beta-oxidation (GO:0032000)4.27698217
9complement activation, alternative pathway (GO:0006957)4.21889389
10membrane raft organization (GO:0031579)4.11817745
11protein localization to endosome (GO:0036010)4.11134181
12regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.08991516
13UDP-N-acetylglucosamine metabolic process (GO:0006047)4.08604197
14negative regulation of fibrinolysis (GO:0051918)4.07482014
15L-phenylalanine metabolic process (GO:0006558)4.04157750
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.04157750
17urea metabolic process (GO:0019627)4.03053001
18urea cycle (GO:0000050)4.03053001
19desmosome organization (GO:0002934)4.00733366
20protein carboxylation (GO:0018214)3.97550384
21peptidyl-glutamic acid carboxylation (GO:0017187)3.97550384
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95510416
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.92996613
24sequestering of extracellular ligand from receptor (GO:0035581)3.92617290
25sulfur amino acid catabolic process (GO:0000098)3.89655895
26collagen fibril organization (GO:0030199)3.88003713
27Golgi transport vesicle coating (GO:0048200)3.83936587
28COPI coating of Golgi vesicle (GO:0048205)3.83936587
29COPII vesicle coating (GO:0048208)3.82091274
30regulation of protein activation cascade (GO:2000257)3.81409427
31aromatic amino acid family catabolic process (GO:0009074)3.77622331
32regulation of fatty acid beta-oxidation (GO:0031998)3.74576914
33iron ion import (GO:0097286)3.71618698
34valine metabolic process (GO:0006573)3.69984217
35plasma lipoprotein particle clearance (GO:0034381)3.69700445
36regulation of complement activation (GO:0030449)3.68429532
37epoxygenase P450 pathway (GO:0019373)3.62601795
38regulation of fibrinolysis (GO:0051917)3.61594762
39cysteine metabolic process (GO:0006534)3.57428048
40nitrogen cycle metabolic process (GO:0071941)3.56145975
41substrate-dependent cell migration (GO:0006929)3.55585314
42skin morphogenesis (GO:0043589)3.54700770
43sphingosine metabolic process (GO:0006670)3.49277493
44keratan sulfate catabolic process (GO:0042340)3.48767794
45positive regulation of lipid catabolic process (GO:0050996)3.46651306
46regulation of triglyceride catabolic process (GO:0010896)3.45112058
47mesenchymal-epithelial cell signaling (GO:0060638)3.44850815
48kynurenine metabolic process (GO:0070189)3.43026728
49growth hormone receptor signaling pathway (GO:0060396)3.42823646
50bile acid biosynthetic process (GO:0006699)3.39976079
51wound healing, spreading of epidermal cells (GO:0035313)3.38637157
52positive regulation of protein autophosphorylation (GO:0031954)3.36935819
53cellular response to vitamin (GO:0071295)3.34301887
54homocysteine metabolic process (GO:0050667)3.33754792
55positive regulation of fatty acid oxidation (GO:0046321)3.32752286
56positive regulation of endothelial cell apoptotic process (GO:2000353)3.29691058
57tryptophan catabolic process (GO:0006569)3.29545110
58indole-containing compound catabolic process (GO:0042436)3.29545110
59indolalkylamine catabolic process (GO:0046218)3.29545110
60regulation of cholesterol storage (GO:0010885)3.27629601
61regulation of cholesterol homeostasis (GO:2000188)3.26874258
62endodermal cell differentiation (GO:0035987)3.24617603
63lysine metabolic process (GO:0006553)3.24147170
64lysine catabolic process (GO:0006554)3.24147170
65regulation of metalloenzyme activity (GO:0048552)3.23314045
66high-density lipoprotein particle remodeling (GO:0034375)3.22814858
67regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.22066293
68chondrocyte proliferation (GO:0035988)3.21612569
69tryptophan metabolic process (GO:0006568)3.19315413
70interleukin-6-mediated signaling pathway (GO:0070102)3.19138145
71regulation of transforming growth factor beta1 production (GO:0032908)3.15686258
72amino-acid betaine metabolic process (GO:0006577)3.13714590
73cellular response to vitamin D (GO:0071305)3.11002433
74acylglycerol homeostasis (GO:0055090)3.10006383
75triglyceride homeostasis (GO:0070328)3.10006383
76glyoxylate metabolic process (GO:0046487)3.09816528
77phospholipid homeostasis (GO:0055091)3.09161706
78protein localization to cell surface (GO:0034394)3.07282918
79barbed-end actin filament capping (GO:0051016)3.06103826
80fibroblast migration (GO:0010761)3.05942560
81diol metabolic process (GO:0034311)3.05483480
82vascular endothelial growth factor signaling pathway (GO:0038084)3.03599607
83cell-substrate junction assembly (GO:0007044)3.02919009
84platelet-derived growth factor receptor signaling pathway (GO:0048008)3.02127755
85blood vessel maturation (GO:0001955)3.01752048
86regulation of sequestering of triglyceride (GO:0010889)3.01142197
87reverse cholesterol transport (GO:0043691)3.00969404
88positive regulation of glycolytic process (GO:0045821)3.00752130
89negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.00167060
90substrate adhesion-dependent cell spreading (GO:0034446)3.00120464
91negative regulation of protein localization to plasma membrane (GO:1903077)2.99824805
92bile acid metabolic process (GO:0008206)2.99406082
93cellular response to growth hormone stimulus (GO:0071378)2.99163693
94sprouting angiogenesis (GO:0002040)2.98596779
95sphingoid metabolic process (GO:0046519)2.98286474
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98055093
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98055093
98extracellular fibril organization (GO:0043206)2.96123064
99fatty acid transmembrane transport (GO:1902001)2.94425800
100type B pancreatic cell proliferation (GO:0044342)2.94380172
101negative regulation of fatty acid transport (GO:2000192)2.94255039
102negative regulation of cholesterol transport (GO:0032375)2.92434585
103negative regulation of sterol transport (GO:0032372)2.92434585
104glomerular visceral epithelial cell development (GO:0072015)2.91924148
105smooth muscle tissue development (GO:0048745)2.90557391
106triglyceride catabolic process (GO:0019433)2.89974539
107mesodermal cell differentiation (GO:0048333)2.89731986
108tyrosine metabolic process (GO:0006570)2.88331277
109fibrinolysis (GO:0042730)2.88251873
110cellular response to interferon-alpha (GO:0035457)2.88026334
111hypotonic response (GO:0006971)2.85950032
112ethanol oxidation (GO:0006069)2.85873753
113plasma lipoprotein particle remodeling (GO:0034369)2.85104664
114protein-lipid complex remodeling (GO:0034368)2.85104664
115macromolecular complex remodeling (GO:0034367)2.85104664
116positive regulation of fibroblast migration (GO:0010763)2.83563149
117regulation of transforming growth factor beta2 production (GO:0032909)2.83266973
118hyaluronan catabolic process (GO:0030214)2.83215866
119protein hydroxylation (GO:0018126)2.82834100
120phospholipid efflux (GO:0033700)2.81568497
121serine family amino acid catabolic process (GO:0009071)2.81538646
122acylglycerol catabolic process (GO:0046464)2.81079986
123neutral lipid catabolic process (GO:0046461)2.81079986
124regulation of plasminogen activation (GO:0010755)2.80694332
125regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.80027164
126dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77771282
127dicarboxylic acid biosynthetic process (GO:0043650)2.77637206
128fatty acid beta-oxidation (GO:0006635)2.76788837
129fibril organization (GO:0097435)2.74975481
130positive regulation of fatty acid metabolic process (GO:0045923)2.74632787
131lipoprotein metabolic process (GO:0042157)2.74158204
132epithelial cell-cell adhesion (GO:0090136)2.74156535
133endosome to melanosome transport (GO:0035646)2.73292132
134endosome to pigment granule transport (GO:0043485)2.73292132
135plasma lipoprotein particle assembly (GO:0034377)2.73178663
136fatty acid oxidation (GO:0019395)2.72660403
137linoleic acid metabolic process (GO:0043651)2.71517295
138protein-lipid complex assembly (GO:0065005)2.71271978
139acetyl-CoA metabolic process (GO:0006084)2.71257710
140positive regulation of triglyceride metabolic process (GO:0090208)2.70545697
141positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70368926
142endothelial cell morphogenesis (GO:0001886)2.69313942
143positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.69149551
144nucleotide-sugar biosynthetic process (GO:0009226)2.68783875
145negative regulation of anoikis (GO:2000811)2.67709437
146apoptotic cell clearance (GO:0043277)2.67216094
147lipid oxidation (GO:0034440)2.65716597
1482-oxoglutarate metabolic process (GO:0006103)2.65587229
149cell adhesion mediated by integrin (GO:0033627)2.64088825
150cholesterol efflux (GO:0033344)2.63091146
151vesicle coating (GO:0006901)2.61807089
152positive regulation of histone deacetylation (GO:0031065)2.60855091
153regulation of fatty acid oxidation (GO:0046320)2.60725864
154lymphangiogenesis (GO:0001946)2.60601979
155negative regulation of chondrocyte differentiation (GO:0032331)2.60491538
156chondrocyte development (GO:0002063)2.59971417
157antigen processing and presentation of endogenous antigen (GO:0019883)2.59866112
158complement activation (GO:0006956)2.59518532
159sterol homeostasis (GO:0055092)2.57442199
160cholesterol homeostasis (GO:0042632)2.57425066
161cellular glucuronidation (GO:0052695)2.56862946
162peptidyl-proline hydroxylation (GO:0019511)2.56653692
163regulation of lipid catabolic process (GO:0050994)2.56456625
164embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56293525
165cellular modified amino acid catabolic process (GO:0042219)2.55791707
166negative regulation of lipid transport (GO:0032369)2.55680062
167aromatic amino acid family metabolic process (GO:0009072)2.54979577
168sphingomyelin metabolic process (GO:0006684)2.54442668
169import into cell (GO:0098657)2.52904497
170negative regulation of fatty acid biosynthetic process (GO:0045717)2.51943128
171regulation of extracellular matrix disassembly (GO:0010715)2.51311578
172regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50827486
173negative regulation of adherens junction organization (GO:1903392)2.49109046
174negative regulation of focal adhesion assembly (GO:0051895)2.49109046
175negative regulation of cell junction assembly (GO:1901889)2.49109046
176negative regulation of axon extension involved in axon guidance (GO:0048843)2.48239015
177negative regulation of stem cell proliferation (GO:2000647)2.47906447
178positive regulation of macrophage activation (GO:0043032)2.47199609
179regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45885525
180collagen metabolic process (GO:0032963)2.44679985
181renal filtration (GO:0097205)2.43776165
182wound healing, spreading of cells (GO:0044319)2.42074926
183negative regulation of nitric oxide biosynthetic process (GO:0045019)2.40872054
184extracellular regulation of signal transduction (GO:1900115)2.40395367
185extracellular negative regulation of signal transduction (GO:1900116)2.40395367
186protein heterotrimerization (GO:0070208)2.40139894
187cell migration involved in sprouting angiogenesis (GO:0002042)2.38981759
188regulation of membrane protein ectodomain proteolysis (GO:0051043)2.38448384
189pericardium development (GO:0060039)2.37045984
190glomerular epithelial cell development (GO:0072310)2.35708848
191wound healing (GO:0042060)2.34696128
192muscle cell migration (GO:0014812)2.34528186
193positive regulation of endothelial cell migration (GO:0010595)2.32810284
194negative regulation of complement activation (GO:0045916)2.32515638
195membrane protein ectodomain proteolysis (GO:0006509)2.32442512
196regulation of protein autophosphorylation (GO:0031952)2.32106787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.49720525
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.86642805
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.70104434
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.35549613
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.26195577
6SMAD_19615063_ChIP-ChIP_OVARY_Human4.13051742
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.23320234
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18340254
9CLOCK_20551151_ChIP-Seq_293T_Human2.95471018
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.81532839
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.72574762
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64885853
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63526149
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.60847663
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.42573855
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.37072432
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09881006
18* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.08560980
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07676470
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.07481169
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.07248432
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04034471
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03275817
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.87365759
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79502415
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.74483406
27GATA1_22025678_ChIP-Seq_K562_Human1.73008916
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.71736043
29AHR_22903824_ChIP-Seq_MCF-7_Human1.70111730
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67659171
31JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67094734
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.65325487
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64850576
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63196026
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.60815223
36SOX2_20726797_ChIP-Seq_SW620_Human1.59898741
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58702876
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.58579770
39TP53_18474530_ChIP-ChIP_U2OS_Human1.52544413
40* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52387562
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52295160
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52132952
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.51715983
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49376697
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47506063
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46376065
47* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44800347
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44490964
49MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42824393
50TP63_23658742_ChIP-Seq_EP156T_Human1.37823379
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.37099098
52* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36737030
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.36666160
54TP53_16413492_ChIP-PET_HCT116_Human1.36116001
55ZNF263_19887448_ChIP-Seq_K562_Human1.35580957
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34318716
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32767061
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30737460
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.30411714
60CJUN_26792858_Chip-Seq_BT549_Human1.28828880
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27572392
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27518749
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27198231
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26018852
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25809809
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23302605
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22641367
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20827073
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18028792
70* BRD4_25478319_ChIP-Seq_HGPS_Human1.16540557
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16456578
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16378356
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15758995
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13936458
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13606580
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13606580
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.12105997
78RUNX_20019798_ChIP-Seq_JUKART_Human1.11864534
79TCF7_22412390_ChIP-Seq_EML_Mouse1.10967285
80GATA4_25053715_ChIP-Seq_YYC3_Human1.10762412
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10312299
82* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10163446
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09513801
84* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.08880869
85FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08565134
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07914862
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07914862
88CDX2_22108803_ChIP-Seq_LS180_Human1.07492399
89TFEB_21752829_ChIP-Seq_HELA_Human1.07472669
90KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07186401
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05325369
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04925437
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.04692318
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.04064974
95* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03851375
96* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03851375
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03805111
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.02989311
99HNF4A_19822575_ChIP-Seq_HepG2_Human1.02620989
100* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02523428
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02429754
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01742577
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01335767
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01213152
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01186507
106VDR_24787735_ChIP-Seq_THP-1_Human0.99286594
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96813938
108GATA6_25053715_ChIP-Seq_YYC3_Human0.96791376
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96401821
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.96160521
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.95969920
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95738411
113ELK1_19687146_ChIP-ChIP_HELA_Human0.95429586
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93380384
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.92798963
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.91902534
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90953829
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90287766
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89731294
120MYB_26560356_Chip-Seq_TH2_Human0.89318243
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89026645
122MAF_26560356_Chip-Seq_TH1_Human0.88957386
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88535831
124MYB_26560356_Chip-Seq_TH1_Human0.88292939
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87872966
126* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87618369
127ELF5_23300383_ChIP-Seq_T47D_Human0.87271256
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87059473
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86322666
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86269057
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.86096880
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85681646
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84450134
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83796547
135AR_21909140_ChIP-Seq_LNCAP_Human0.83085085
136GATA2_19941826_ChIP-Seq_K562_Human0.82789522
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80657817
138ATF3_27146783_Chip-Seq_COLON_Human0.80456278
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.79928981
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79694476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.62182500
2MP0008438_abnormal_cutaneous_collagen4.13601405
3MP0005360_urolithiasis4.05081853
4MP0003705_abnormal_hypodermis_morpholog3.59705337
5MP0003950_abnormal_plasma_membrane3.57281942
6MP0005365_abnormal_bile_salt3.57098700
7MP0005085_abnormal_gallbladder_physiolo3.06730721
8MP0005275_abnormal_skin_tensile2.91531144
9MP0003252_abnormal_bile_duct2.85921434
10MP0009780_abnormal_chondrocyte_physiolo2.67544902
11MP0010329_abnormal_lipoprotein_level2.45145087
12MP0008875_abnormal_xenobiotic_pharmacok2.35444662
13MP0003300_gastrointestinal_ulcer2.28345124
14MP0005670_abnormal_white_adipose2.08831262
15MP0005257_abnormal_intraocular_pressure2.00898819
16MP0010352_gastrointestinal_tract_polyps1.97499748
17MP0003191_abnormal_cellular_cholesterol1.78015173
18MP0004185_abnormal_adipocyte_glucose1.77660070
19MP0003941_abnormal_skin_development1.76324484
20MP0005666_abnormal_adipose_tissue1.76176101
21MP0000609_abnormal_liver_physiology1.72147035
22MP0005503_abnormal_tendon_morphology1.68615616
23MP0009840_abnormal_foam_cell1.67069134
24MP0003566_abnormal_cell_adhesion1.65279329
25MP0005171_absent_coat_pigmentation1.61218923
26MP0004130_abnormal_muscle_cell1.60500003
27MP0002166_altered_tumor_susceptibility1.59463951
28MP0010234_abnormal_vibrissa_follicle1.58670876
29MP0001879_abnormal_lymphatic_vessel1.57294553
30MP0001542_abnormal_bone_strength1.56956464
31MP0005623_abnormal_meninges_morphology1.56537005
32MP0002138_abnormal_hepatobiliary_system1.55045511
33MP0005083_abnormal_biliary_tract1.51058344
34MP0002060_abnormal_skin_morphology1.47355548
35MP0002118_abnormal_lipid_homeostasis1.44909106
36MP0003806_abnormal_nucleotide_metabolis1.43568424
37MP0001666_abnormal_nutrient_absorption1.41538212
38MP0005023_abnormal_wound_healing1.34594459
39MP0003828_pulmonary_edema1.31961907
40MP0002254_reproductive_system_inflammat1.29990933
41MP0002877_abnormal_melanocyte_morpholog1.29147448
42MP0005076_abnormal_cell_differentiation1.28325860
43MP0005375_adipose_tissue_phenotype1.28085677
44MP0004272_abnormal_basement_membrane1.27647686
45MP0005332_abnormal_amino_acid1.26868032
46MP0009384_cardiac_valve_regurgitation1.24911525
47MP0001958_emphysema1.24847879
48MP0001661_extended_life_span1.23848049
49MP0003279_aneurysm1.23676028
50MP0006054_spinal_hemorrhage1.21435178
51MP0000015_abnormal_ear_pigmentation1.20772073
52MP0005165_increased_susceptibility_to1.18270455
53MP0003091_abnormal_cell_migration1.17312924
54MP0005164_abnormal_response_to1.16194181
55MP0003045_fibrosis1.14186129
56MP0005319_abnormal_enzyme/_coenzyme1.14095253
57MP0005409_darkened_coat_color1.13694529
58MP0002006_tumorigenesis1.09667239
59MP0001243_abnormal_dermal_layer1.08797596
60MP0002168_other_aberrant_phenotype1.08632556
61MP0002971_abnormal_brown_adipose1.08371831
62MP0002009_preneoplasia1.07317313
63MP0000598_abnormal_liver_morphology1.06280180
64MP0005595_abnormal_vascular_smooth1.05538762
65MP0010368_abnormal_lymphatic_system1.04262400
66MP0000371_diluted_coat_color1.03986678
67MP0004947_skin_inflammation1.02369322
68MP0000569_abnormal_digit_pigmentation1.00158528
69MP0009115_abnormal_fat_cell1.00127755
70MP0003436_decreased_susceptibility_to0.99935635
71MP0003195_calcinosis0.99766138
72MP0010307_abnormal_tumor_latency0.99271468
73MP0005174_abnormal_tail_pigmentation0.96652722
74MP0003868_abnormal_feces_composition0.95371529
75MP0009053_abnormal_anal_canal0.95220681
76MP0003453_abnormal_keratinocyte_physiol0.94974638
77MP0005508_abnormal_skeleton_morphology0.93654738
78MP0010386_abnormal_urinary_bladder0.93587694
79MP0000003_abnormal_adipose_tissue0.92918471
80MP0000383_abnormal_hair_follicle0.92813081
81MP0005334_abnormal_fat_pad0.92017442
82MP0004084_abnormal_cardiac_muscle0.89958742
83MP0009643_abnormal_urine_homeostasis0.87924605
84MP0002896_abnormal_bone_mineralization0.86512441
85MP0008004_abnormal_stomach_pH0.86316175
86MP0002928_abnormal_bile_duct0.84330224
87MP0004233_abnormal_muscle_weight0.84013159
88MP0009763_increased_sensitivity_to0.83605738
89MP0001881_abnormal_mammary_gland0.83551118
90MP0001533_abnormal_skeleton_physiology0.81560889
91MP0001348_abnormal_lacrimal_gland0.80730659
92MP0005647_abnormal_sex_gland0.80612425
93MP0010771_integument_phenotype0.80413277
94MP0001299_abnormal_eye_distance/0.80141914
95MP0004019_abnormal_vitamin_homeostasis0.79927221
96MP0004134_abnormal_chest_morphology0.79198692
97MP0001851_eye_inflammation0.78477165
98MP0005501_abnormal_skin_physiology0.78373117
99MP0005584_abnormal_enzyme/coenzyme_acti0.77961078
100MP0000427_abnormal_hair_cycle0.76378780
101MP0000685_abnormal_immune_system0.76249834
102MP0000762_abnormal_tongue_morphology0.75913664
103MP0000733_abnormal_muscle_development0.75724101
104MP0000343_altered_response_to0.75476740
105MP0000604_amyloidosis0.75228138
106MP0002796_impaired_skin_barrier0.74188473
107MP0002295_abnormal_pulmonary_circulatio0.74105143
108MP0003303_peritoneal_inflammation0.73549198
109MP0008057_abnormal_DNA_replication0.73296089
110MP0005220_abnormal_exocrine_pancreas0.73068331
111MP0003656_abnormal_erythrocyte_physiolo0.70401394
112MP0002970_abnormal_white_adipose0.69996953
113MP0010678_abnormal_skin_adnexa0.69723063
114MP0005397_hematopoietic_system_phenotyp0.69392956
115MP0001545_abnormal_hematopoietic_system0.69392956
116MP0005464_abnormal_platelet_physiology0.69328547
117MP0001915_intracranial_hemorrhage0.68610146
118MP0002998_abnormal_bone_remodeling0.68546668
119MP0004883_abnormal_blood_vessel0.68470979
120MP0005197_abnormal_uvea_morphology0.67843369
121MP0009764_decreased_sensitivity_to0.67243569
122MP0000013_abnormal_adipose_tissue0.67006206
123MP0000377_abnormal_hair_follicle0.66558169
124MP0002108_abnormal_muscle_morphology0.65928322
125MP0001191_abnormal_skin_condition0.65813178
126MP0005390_skeleton_phenotype0.65412329
127MP0003724_increased_susceptibility_to0.65370784
128MP0005621_abnormal_cell_physiology0.65016298
129MP0005410_abnormal_fertilization0.65002649
130MP0000767_abnormal_smooth_muscle0.64981999
131MP0002128_abnormal_blood_circulation0.64758969
132MP0008469_abnormal_protein_level0.64476613
133MP0000249_abnormal_blood_vessel0.64029434
134MP0005408_hypopigmentation0.61449370
135MP0005058_abnormal_lysosome_morphology0.61411717
136MP0000627_abnormal_mammary_gland0.61408526
137MP0001756_abnormal_urination0.59294938
138MP0003448_altered_tumor_morphology0.59249620
139MP0001835_abnormal_antigen_presentation0.59234920
140MP0003795_abnormal_bone_structure0.58986897
141MP0001216_abnormal_epidermal_layer0.58905932
142MP0001614_abnormal_blood_vessel0.58628919
143MP0005388_respiratory_system_phenotype0.58406778
144MP0002133_abnormal_respiratory_system0.58406778
145MP0000465_gastrointestinal_hemorrhage0.58349505
146MP0002332_abnormal_exercise_endurance0.57973939
147MP0005395_other_phenotype0.57920949

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.96228318
2Protrusio acetabuli (HP:0003179)4.12154976
3Xanthomatosis (HP:0000991)4.01135182
4Complement deficiency (HP:0004431)3.89666329
5Vascular tortuosity (HP:0004948)3.85902633
6Intrahepatic cholestasis (HP:0001406)3.83823886
7Myocardial infarction (HP:0001658)3.82601501
8Arterial tortuosity (HP:0005116)3.78280657
9Spondylolisthesis (HP:0003302)3.59528944
10Peritonitis (HP:0002586)3.56070265
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.54029950
12Premature rupture of membranes (HP:0001788)3.47122300
13Epidermoid cyst (HP:0200040)3.33399113
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.23653393
15Abnormality of the common coagulation pathway (HP:0010990)3.22667629
16Short nail (HP:0001799)3.15251176
17Hyperlipoproteinemia (HP:0010980)3.08482255
18Ankle contracture (HP:0006466)3.07410555
19Wormian bones (HP:0002645)3.03761899
20Hypobetalipoproteinemia (HP:0003563)3.00143217
21Aortic aneurysm (HP:0004942)2.95496915
22Abnormality of complement system (HP:0005339)2.93988998
23Hypoalphalipoproteinemia (HP:0003233)2.89008986
24Vertebral compression fractures (HP:0002953)2.88466818
25Aortic dissection (HP:0002647)2.85960783
26Mitral valve prolapse (HP:0001634)2.85693324
27Cerebral aneurysm (HP:0004944)2.85310762
28Prolonged partial thromboplastin time (HP:0003645)2.85007533
29Absent frontal sinuses (HP:0002688)2.77503437
30Hypolipoproteinemia (HP:0010981)2.75117288
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.69189323
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68578897
33Hypercholesterolemia (HP:0003124)2.65822155
34Reduced subcutaneous adipose tissue (HP:0003758)2.63372703
35Overgrowth (HP:0001548)2.60890114
36Mitral stenosis (HP:0001718)2.59325004
37Shallow orbits (HP:0000586)2.58719960
38Hypoglycemic coma (HP:0001325)2.58578949
39Broad metatarsal (HP:0001783)2.56939349
40Hemorrhage of the eye (HP:0011885)2.55984800
41Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54525835
42Glucose intolerance (HP:0000833)2.50276085
43Increased mean platelet volume (HP:0011877)2.49242744
44Aortic regurgitation (HP:0001659)2.48428833
45Skin nodule (HP:0200036)2.47580257
46Abnormality of the intrinsic pathway (HP:0010989)2.45323485
47Esophageal varix (HP:0002040)2.43896813
48Joint hemorrhage (HP:0005261)2.40236519
49Spinal rigidity (HP:0003306)2.39920000
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.36894733
51Ketosis (HP:0001946)2.34645270
52Hyperammonemia (HP:0001987)2.34363246
53Tetraparesis (HP:0002273)2.34249113
54Dilatation of the ascending aorta (HP:0005111)2.33020432
55Delayed closure of the anterior fontanelle (HP:0001476)2.30717147
56Cervical subluxation (HP:0003308)2.30611375
57Spinal cord lesions (HP:0100561)2.28440819
58Syringomyelia (HP:0003396)2.28440819
59Aneurysm (HP:0002617)2.26420504
60Elbow flexion contracture (HP:0002987)2.24342424
61Cardiovascular calcification (HP:0011915)2.23169155
62Atrophic scars (HP:0001075)2.22733541
63Ectopia lentis (HP:0001083)2.22404284
64Abnormal platelet volume (HP:0011876)2.22325514
65Natal tooth (HP:0000695)2.21643447
66Abnormality of the distal phalanges of the toes (HP:0010182)2.19522898
67Spinal cord compression (HP:0002176)2.18747445
68Entropion (HP:0000621)2.15690672
69Abnormality of the frontal sinuses (HP:0002687)2.13555582
70Aortic valve stenosis (HP:0001650)2.12031684
71Abnormality of the acetabulum (HP:0003170)2.12003001
72Hepatocellular carcinoma (HP:0001402)2.11849385
73Subacute progressive viral hepatitis (HP:0006572)2.08395475
74Abnormality of proline metabolism (HP:0010907)2.08310106
75Hydroxyprolinuria (HP:0003080)2.08310106
76Follicular hyperkeratosis (HP:0007502)2.07564671
77Hematochezia (HP:0002573)2.06817739
78Spastic diplegia (HP:0001264)2.06467101
79Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.05312727
80Hypoplasia of the iris (HP:0007676)2.04215626
81Ulnar bowing (HP:0003031)2.03299591
82Fat malabsorption (HP:0002630)2.02005251
83Ovoid vertebral bodies (HP:0003300)2.01046485
84Abnormal glucose tolerance (HP:0001952)2.00756807
85Right ventricular cardiomyopathy (HP:0011663)2.00429443
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.00364466
87Abnormality of glycolipid metabolism (HP:0010969)2.00364466
88Abnormality of liposaccharide metabolism (HP:0010968)2.00364466
89Abnormal cartilage morphology (HP:0002763)2.00347881
90Blue sclerae (HP:0000592)1.99792969
91Abnormality of carpal bone ossification (HP:0006257)1.99361056
92Bilateral sensorineural hearing impairment (HP:0008619)1.98414578
93Hypertriglyceridemia (HP:0002155)1.98164224
94Macroorchidism (HP:0000053)1.96163427
95Abnormality of serine family amino acid metabolism (HP:0010894)1.95759640
96Abnormality of glycine metabolism (HP:0010895)1.95759640
97Increased connective tissue (HP:0009025)1.95141891
98Gingival bleeding (HP:0000225)1.94929829
99Persistence of primary teeth (HP:0006335)1.93616573
100Lymphangioma (HP:0100764)1.93429551
101Joint laxity (HP:0001388)1.91474718
102Abnormality of oral frenula (HP:0000190)1.91419816
103Hyperglycinuria (HP:0003108)1.90651847
104Acanthosis nigricans (HP:0000956)1.90490043
105Relative macrocephaly (HP:0004482)1.89822970
106Knee flexion contracture (HP:0006380)1.89261211
107* Osteolytic defects of the hand bones (HP:0009699)1.88554499
108* Osteolytic defects of the phalanges of the hand (HP:0009771)1.88554499
109Metaphyseal dysplasia (HP:0100255)1.86465628
110Turricephaly (HP:0000262)1.85952810
111Abnormality of the peritoneum (HP:0002585)1.84913110
112Onycholysis (HP:0001806)1.84608598
113Abnormal auditory evoked potentials (HP:0006958)1.84607506
114Asymmetry of the thorax (HP:0001555)1.82973079
115Striae distensae (HP:0001065)1.82361681
116Nephritis (HP:0000123)1.81310444
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80890594
118Albinism (HP:0001022)1.80583822
119Genu recurvatum (HP:0002816)1.80508302
120Hyperextensible skin (HP:0000974)1.79631262
121Vascular calcification (HP:0004934)1.79496414
122Ankyloglossia (HP:0010296)1.78934560
123Urinary glycosaminoglycan excretion (HP:0003541)1.78679598
124Mucopolysacchariduria (HP:0008155)1.78679598
125Abnormality of skull ossification (HP:0002703)1.78095276
126Enlarged penis (HP:0000040)1.77833096
127Abnormal ossification of hand bones (HP:0005921)1.76637185
128Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.76177152
129Hyperglycinemia (HP:0002154)1.76119601
130Bladder diverticulum (HP:0000015)1.75975100
131Wrist flexion contracture (HP:0001239)1.75923811
132Disproportionate tall stature (HP:0001519)1.75553474
133Alopecia of scalp (HP:0002293)1.75338499
134Abnormal delivery (HP:0001787)1.74478645
135Decreased skull ossification (HP:0004331)1.74437140
136Abnormality of methionine metabolism (HP:0010901)1.74430589
137Soft skin (HP:0000977)1.74338053
138Abnormality of dentin (HP:0010299)1.74098648
139Delayed cranial suture closure (HP:0000270)1.74023703
140Polycythemia (HP:0001901)1.74017488
141Systemic lupus erythematosus (HP:0002725)1.73931129
142Periodontitis (HP:0000704)1.73240496
143Abnormality of purine metabolism (HP:0004352)1.72561461
144Slender build (HP:0001533)1.72455940
145Abnormal hand bone ossification (HP:0010660)1.72230369
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71893087
147Abnormality of the 4th metacarpal (HP:0010012)1.70590069
148Broad face (HP:0000283)1.70376107
149Back pain (HP:0003418)1.70160500
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.69995033
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69969050
152Short 4th metacarpal (HP:0010044)1.69969050
153Rectal prolapse (HP:0002035)1.69050995
154Abnormality of Sharpey fibers (HP:0100685)1.69038885
155Coarse hair (HP:0002208)1.68179269
156Camptodactyly of toe (HP:0001836)1.68119668
157Increased density of long bones (HP:0006392)1.68049912
158Cutaneous melanoma (HP:0012056)1.67610413
159Mesomelia (HP:0003027)1.67185476
160Chondrocalcinosis (HP:0000934)1.67074511
161Gastrointestinal infarctions (HP:0005244)1.66292386
162Acanthocytosis (HP:0001927)1.66211655
163Dysostosis multiplex (HP:0000943)1.65647241
164Hamartoma of the eye (HP:0010568)1.65502814
165Ketoacidosis (HP:0001993)1.65234514
166Infantile muscular hypotonia (HP:0008947)1.64544329
167Abnormality of fatty-acid metabolism (HP:0004359)1.64285846
168Tibial bowing (HP:0002982)1.64119569
169Fragile skin (HP:0001030)1.64026566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.70510471
2TRIB33.65244521
3MYLK2.88543874
4LATS12.86362963
5MST42.77158555
6ERN12.73993725
7PKN22.64413786
8FGFR42.52043398
9CAMK1D2.47558933
10FRK2.36755693
11FGFR22.26373433
12RIPK12.01166706
13PDGFRA1.98501517
14TTN1.95672213
15EIF2AK31.92789985
16FGFR31.91058390
17CAMK1G1.84285456
18PTK61.83814090
19NEK91.82051183
20EEF2K1.80770488
21STK31.75662335
22TIE11.74933740
23ERBB31.74628180
24MAP3K121.71036341
25CDK121.67213845
26LIMK11.66873341
27JAK11.65704582
28FLT31.61966034
29DDR21.61833813
30CDK61.61607791
31EIF2AK11.59617654
32BRSK21.58042593
33EPHB11.57271479
34TRIM281.53679993
35IRAK31.50675631
36EPHA21.47489474
37TYK21.47381298
38BCKDK1.44143420
39AKT31.43948129
40TAOK31.41108059
41EPHA31.40055202
42JAK31.39062122
43LRRK21.36635724
44PBK1.36176662
45MAP3K101.34992358
46PDK41.28077708
47PDK31.28077708
48LATS21.24577254
49ACVR1B1.23197259
50BMPR21.20367741
51TGFBR21.20046857
52PDGFRB1.16862482
53SIK31.16840762
54STK101.16777120
55STK38L1.14688052
56TRPM71.11917098
57MTOR1.11741624
58MST1R1.10899491
59MOS1.09450283
60INSRR1.08353624
61BMX1.08054393
62MAPKAPK31.07797225
63STK381.05430564
64ICK1.04464036
65PAK21.00996031
66FGFR10.98889180
67STK390.97807272
68RET0.96667099
69TESK10.95694723
70TGFBR10.95610829
71PTK20.93631586
72MET0.93340418
73JAK20.92922484
74ILK0.91424500
75CSF1R0.90868491
76SCYL20.88015158
77MAP3K140.86946531
78ABL20.85923758
79RPS6KA40.84724328
80MAP2K30.80962058
81TBK10.80757492
82DYRK1B0.79561464
83ZAP700.78787415
84MAP3K20.75745709
85MAP2K10.75713599
86STK240.75207541
87CAMKK20.75187802
88PLK20.74694926
89PRKAA20.74674311
90CHUK0.74179883
91TSSK60.72553011
92MAP3K70.71961731
93NUAK10.71464057
94NEK10.71384259
95BCR0.70465350
96CDK40.68810815
97MAP4K10.67348587
98MAPK110.66438523
99ITK0.65778890
100CSK0.65597012
101FER0.64808394
102MAP3K60.63924360
103PRKD20.63633346
104MAP3K30.61365432
105PAK30.59522233
106KIT0.58292106
107GSK3A0.57480053
108CDK90.56939274
109BMPR1B0.56771400
110PDK20.56574490
111CLK10.56150589
112NEK20.54249300
113ROCK10.53728864
114ADRBK10.52676512
115KSR10.52552753
116SGK30.52202054
117TEC0.51758673
118DMPK0.51333518
119PTK2B0.50506837
120EGFR0.49995730
121ROCK20.49694919
122IGF1R0.49112126
123PIK3CG0.48731276
124PIK3CA0.48207129
125PRKCH0.47303734
126ERBB40.47248617
127STK40.45051920
128PDK10.43488838
129PDPK10.42057319
130MELK0.42005600
131INSR0.41626883
132PRKCE0.41308373
133CDK80.41232370
134PAK40.40841040
135WNK10.40797552
136IKBKB0.40415486
137PRKG20.39842263
138PRKD30.39722087
139PLK30.39398224
140MAP3K80.38407333
141MAPKAPK50.38235530
142MAPKAPK20.37975172
143ABL10.36933757
144ERBB20.35908655
145HCK0.35437846
146EPHB20.35135386
147PRKCI0.35071578
148TAF10.34975064
149IKBKE0.34640319
150NEK60.34329554
151PRKCQ0.34050249
152LMTK20.33714608
153PIM10.33457951
154EIF2AK20.33244629
155NTRK10.32768914

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.61105149
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.29351926
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64585493
4Fatty acid degradation_Homo sapiens_hsa000712.54239512
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.45466961
6Complement and coagulation cascades_Homo sapiens_hsa046102.45075620
7PPAR signaling pathway_Homo sapiens_hsa033202.44506759
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.39731331
9Arginine biosynthesis_Homo sapiens_hsa002202.23209019
10Tryptophan metabolism_Homo sapiens_hsa003802.15056498
11Caffeine metabolism_Homo sapiens_hsa002322.10695587
12Fatty acid metabolism_Homo sapiens_hsa012122.08222744
13Sphingolipid metabolism_Homo sapiens_hsa006002.04083863
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.03736064
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00601878
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00518482
17Propanoate metabolism_Homo sapiens_hsa006401.92464748
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91357541
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86413040
20Fatty acid biosynthesis_Homo sapiens_hsa000611.85851841
21Staphylococcus aureus infection_Homo sapiens_hsa051501.82914290
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71823528
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69517760
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.58310255
25Melanoma_Homo sapiens_hsa052181.55145482
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54293088
27TGF-beta signaling pathway_Homo sapiens_hsa043501.47761703
28Selenocompound metabolism_Homo sapiens_hsa004501.46665171
29Peroxisome_Homo sapiens_hsa041461.41352280
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39018539
31Other glycan degradation_Homo sapiens_hsa005111.38841432
32Chemical carcinogenesis_Homo sapiens_hsa052041.38528494
33Lysosome_Homo sapiens_hsa041421.37316507
34Thyroid cancer_Homo sapiens_hsa052161.33023509
35Lysine degradation_Homo sapiens_hsa003101.31377973
36N-Glycan biosynthesis_Homo sapiens_hsa005101.31362943
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27977378
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26838352
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.24287418
40Bile secretion_Homo sapiens_hsa049761.23680118
41Shigellosis_Homo sapiens_hsa051311.21695566
42beta-Alanine metabolism_Homo sapiens_hsa004101.19203458
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18523128
44Butanoate metabolism_Homo sapiens_hsa006501.17019109
45Pyruvate metabolism_Homo sapiens_hsa006201.16519107
46ABC transporters_Homo sapiens_hsa020101.16322234
47p53 signaling pathway_Homo sapiens_hsa041151.13995200
48Fat digestion and absorption_Homo sapiens_hsa049751.12935976
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.12194110
50Histidine metabolism_Homo sapiens_hsa003401.10633651
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09082431
52Phenylalanine metabolism_Homo sapiens_hsa003601.07257732
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06773696
54ECM-receptor interaction_Homo sapiens_hsa045121.06137821
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.03071951
56Retinol metabolism_Homo sapiens_hsa008301.02590206
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02259671
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02187741
59Insulin resistance_Homo sapiens_hsa049311.01107877
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00585485
61Starch and sucrose metabolism_Homo sapiens_hsa005001.00251120
62Glycerolipid metabolism_Homo sapiens_hsa005610.99669546
63Renal cell carcinoma_Homo sapiens_hsa052110.97071532
64Pathways in cancer_Homo sapiens_hsa052000.94538680
65Dorso-ventral axis formation_Homo sapiens_hsa043200.92072043
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91965633
67Sulfur metabolism_Homo sapiens_hsa009200.91225363
68Tyrosine metabolism_Homo sapiens_hsa003500.89535974
69Glioma_Homo sapiens_hsa052140.88770665
70Carbon metabolism_Homo sapiens_hsa012000.87597340
71Hippo signaling pathway_Homo sapiens_hsa043900.86835567
72Small cell lung cancer_Homo sapiens_hsa052220.84215948
73Vibrio cholerae infection_Homo sapiens_hsa051100.84022003
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.78070753
75Focal adhesion_Homo sapiens_hsa045100.76102888
76Endocytosis_Homo sapiens_hsa041440.75698063
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75195437
78Galactose metabolism_Homo sapiens_hsa000520.73901218
79AMPK signaling pathway_Homo sapiens_hsa041520.73571568
80Biosynthesis of amino acids_Homo sapiens_hsa012300.70788261
81Phagosome_Homo sapiens_hsa041450.70541330
82Dilated cardiomyopathy_Homo sapiens_hsa054140.68682963
83Hepatitis B_Homo sapiens_hsa051610.68395340
84Amoebiasis_Homo sapiens_hsa051460.67217645
85Toxoplasmosis_Homo sapiens_hsa051450.67183958
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67116169
87Chronic myeloid leukemia_Homo sapiens_hsa052200.66426675
88Adherens junction_Homo sapiens_hsa045200.65933775
89Steroid biosynthesis_Homo sapiens_hsa001000.65844096
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.65804078
91Proteoglycans in cancer_Homo sapiens_hsa052050.65013020
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.64920851
93Tight junction_Homo sapiens_hsa045300.63262496
94Circadian rhythm_Homo sapiens_hsa047100.62653112
95Inositol phosphate metabolism_Homo sapiens_hsa005620.62353353
96Mineral absorption_Homo sapiens_hsa049780.61198019
97Endometrial cancer_Homo sapiens_hsa052130.58978232
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58449163
99Viral carcinogenesis_Homo sapiens_hsa052030.57216219
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57131527
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55594144
102Glutathione metabolism_Homo sapiens_hsa004800.55436356
103Non-homologous end-joining_Homo sapiens_hsa034500.55395024
104Vitamin B6 metabolism_Homo sapiens_hsa007500.55289887
105Salmonella infection_Homo sapiens_hsa051320.54756369
106Protein export_Homo sapiens_hsa030600.54696078
107Protein digestion and absorption_Homo sapiens_hsa049740.54427997
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54421300
109Pertussis_Homo sapiens_hsa051330.54268701
110One carbon pool by folate_Homo sapiens_hsa006700.53896386
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52207077
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.50791090
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48037276
114HIF-1 signaling pathway_Homo sapiens_hsa040660.47878699
115Vitamin digestion and absorption_Homo sapiens_hsa049770.47667960
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47454127
117Apoptosis_Homo sapiens_hsa042100.46500697
118Legionellosis_Homo sapiens_hsa051340.46096400
119Pancreatic cancer_Homo sapiens_hsa052120.45855573
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45760830
121Glucagon signaling pathway_Homo sapiens_hsa049220.44956643
122Rap1 signaling pathway_Homo sapiens_hsa040150.44374513
123Renin-angiotensin system_Homo sapiens_hsa046140.44274839
124Non-small cell lung cancer_Homo sapiens_hsa052230.43737443
125Malaria_Homo sapiens_hsa051440.43631160
126Systemic lupus erythematosus_Homo sapiens_hsa053220.42722311
127Insulin signaling pathway_Homo sapiens_hsa049100.41279449
128mTOR signaling pathway_Homo sapiens_hsa041500.41091859
129MicroRNAs in cancer_Homo sapiens_hsa052060.40918088
130FoxO signaling pathway_Homo sapiens_hsa040680.40886623
131Pentose phosphate pathway_Homo sapiens_hsa000300.40794340
132Gap junction_Homo sapiens_hsa045400.39590459
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39152550
134Viral myocarditis_Homo sapiens_hsa054160.38064827
135Leishmaniasis_Homo sapiens_hsa051400.38018618
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.37777876
137Bladder cancer_Homo sapiens_hsa052190.37539230
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37402706
139Fatty acid elongation_Homo sapiens_hsa000620.37097307
140Acute myeloid leukemia_Homo sapiens_hsa052210.36301166
141Osteoclast differentiation_Homo sapiens_hsa043800.35960159
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.35823996
143Prostate cancer_Homo sapiens_hsa052150.35804227
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35708925
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.35453073
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34618342
147TNF signaling pathway_Homo sapiens_hsa046680.34275732
148African trypanosomiasis_Homo sapiens_hsa051430.34156892
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33134943
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.32937441
151Antigen processing and presentation_Homo sapiens_hsa046120.32936544
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32890161
153Hematopoietic cell lineage_Homo sapiens_hsa046400.31646859
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31317689
155Measles_Homo sapiens_hsa051620.29124907
156Platelet activation_Homo sapiens_hsa046110.27919527
157Prolactin signaling pathway_Homo sapiens_hsa049170.27003572
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.26887332
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26691875
160Folate biosynthesis_Homo sapiens_hsa007900.26520512
161Hepatitis C_Homo sapiens_hsa051600.26269017

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