ATOH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.30530526
2UDP-N-acetylglucosamine metabolic process (GO:0006047)8.11978804
3regulation of guanylate cyclase activity (GO:0031282)7.80229390
4sequestering of actin monomers (GO:0042989)7.69278573
5vitamin A metabolic process (GO:0006776)7.25101484
6intestinal cholesterol absorption (GO:0030299)6.58613871
7maintenance of gastrointestinal epithelium (GO:0030277)6.19386026
8actin filament depolymerization (GO:0030042)6.19057695
9angiotensin maturation (GO:0002003)5.90591096
10intestinal epithelial cell development (GO:0060576)5.84905109
11positive regulation of guanylate cyclase activity (GO:0031284)5.80084443
12positive regulation of respiratory burst (GO:0060267)5.77410520
13NADH metabolic process (GO:0006734)5.77299257
14regulation of systemic arterial blood pressure by hormone (GO:0001990)5.60911238
15regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.60911238
16endocrine process (GO:0050886)5.60911238
17lipoprotein transport (GO:0042953)5.47865128
18epoxygenase P450 pathway (GO:0019373)5.38230699
19fat-soluble vitamin biosynthetic process (GO:0042362)5.19167250
20regulation of systemic arterial blood pressure (GO:0003073)5.17466297
21sulfation (GO:0051923)5.10670967
22regulation of cellular extravasation (GO:0002691)5.06316261
23epithelial structure maintenance (GO:0010669)5.00066863
24receptor guanylyl cyclase signaling pathway (GO:0007168)4.95614673
25digestive system process (GO:0022600)4.92783899
26O-glycan processing (GO:0016266)4.92192323
27regulation of cGMP biosynthetic process (GO:0030826)4.79825744
28renal system process involved in regulation of blood volume (GO:0001977)4.78052155
29hormone catabolic process (GO:0042447)4.73901298
30flavonoid metabolic process (GO:0009812)4.70206420
31sulfate transmembrane transport (GO:1902358)4.58190426
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.54579663
33purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.54579663
34bundle of His cell to Purkinje myocyte communication (GO:0086069)4.50711729
35virion attachment to host cell (GO:0019062)4.47923546
36adhesion of symbiont to host cell (GO:0044650)4.47923546
37fructose metabolic process (GO:0006000)4.46105948
38bile acid and bile salt transport (GO:0015721)4.45670310
39regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.44925967
40gonadal mesoderm development (GO:0007506)4.38399006
41regulation of vitamin metabolic process (GO:0030656)4.33578066
42calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.27144064
43auditory receptor cell differentiation (GO:0042491)4.26621879
44diacylglycerol metabolic process (GO:0046339)4.24989672
45cellular response to hepatocyte growth factor stimulus (GO:0035729)4.20639371
46response to hepatocyte growth factor (GO:0035728)4.20639371
47drug metabolic process (GO:0017144)4.16356415
48nucleotide-sugar biosynthetic process (GO:0009226)4.11883018
49cellular glucuronidation (GO:0052695)3.92527553
50glomerular filtration (GO:0003094)3.91142404
51regulation of cGMP metabolic process (GO:0030823)3.90892581
52urea cycle (GO:0000050)3.85142927
53regulation of pseudopodium assembly (GO:0031272)3.82079155
54regulation of triglyceride catabolic process (GO:0010896)3.81716267
55nucleotide-sugar metabolic process (GO:0009225)3.80125987
56glomerulus development (GO:0032835)3.77911910
57renal system development (GO:0072001)3.77047446
58sulfate transport (GO:0008272)3.74540020
59peptide hormone processing (GO:0016486)3.73673168
60thrombin receptor signaling pathway (GO:0070493)3.73134575
61midgut development (GO:0007494)3.68351110
62positive regulation of actin filament depolymerization (GO:0030836)3.66805921
63urea metabolic process (GO:0019627)3.65916778
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65685933
65endocardial cushion development (GO:0003197)3.62776416
66transcytosis (GO:0045056)3.61969069
67regulation of bile acid biosynthetic process (GO:0070857)3.61780268
68arginine metabolic process (GO:0006525)3.59850048
69regulation of respiratory burst (GO:0060263)3.59637700
70drug catabolic process (GO:0042737)3.57740315
71cGMP biosynthetic process (GO:0006182)3.52689362
72uronic acid metabolic process (GO:0006063)3.51960134
73glucuronate metabolic process (GO:0019585)3.51960134
74renal filtration (GO:0097205)3.50397529
75oligosaccharide biosynthetic process (GO:0009312)3.49943011
76lung secretory cell differentiation (GO:0061140)3.49808354
77adhesion of symbiont to host (GO:0044406)3.48377177
78glucocorticoid biosynthetic process (GO:0006704)3.46513337
79very-low-density lipoprotein particle assembly (GO:0034379)3.46000056
80ethanol metabolic process (GO:0006067)3.45201646
81exogenous drug catabolic process (GO:0042738)3.42831188
82positive regulation of cGMP biosynthetic process (GO:0030828)3.40825851
83kidney morphogenesis (GO:0060993)3.39692097
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.39405891
85peptide catabolic process (GO:0043171)3.38569556
86vitamin transport (GO:0051180)3.38114539
87positive regulation of glycoprotein biosynthetic process (GO:0010560)3.37931482
88skeletal muscle adaptation (GO:0043501)3.36308014
89glandular epithelial cell differentiation (GO:0002067)3.35792341
90sulfur compound transport (GO:0072348)3.31755641
91sperm capacitation (GO:0048240)3.29949939
92transepithelial transport (GO:0070633)3.29434228
93striated muscle atrophy (GO:0014891)3.25531480
94alkaloid metabolic process (GO:0009820)3.24727621
95bicarbonate transport (GO:0015701)3.22329727
96proximal/distal pattern formation (GO:0009954)3.21049831
97vitamin transmembrane transport (GO:0035461)3.18648900
98nitrogen cycle metabolic process (GO:0071941)3.16211598
99cellular response to nitric oxide (GO:0071732)3.15988144
100positive regulation of Rho protein signal transduction (GO:0035025)3.15850553
101L-fucose catabolic process (GO:0042355)3.15596891
102fucose catabolic process (GO:0019317)3.15596891
103L-fucose metabolic process (GO:0042354)3.15596891
104ethanol oxidation (GO:0006069)3.15190707
105primary alcohol catabolic process (GO:0034310)3.15159208
106homocysteine metabolic process (GO:0050667)3.14642970
107nucleoside diphosphate biosynthetic process (GO:0009133)3.11254413
108cGMP-mediated signaling (GO:0019934)3.07903691
109negative regulation of keratinocyte proliferation (GO:0010839)3.06492783
110digestion (GO:0007586)3.04066101
111cytoskeletal anchoring at plasma membrane (GO:0007016)3.02920500
112protein O-linked glycosylation (GO:0006493)3.02848505
113antibacterial humoral response (GO:0019731)3.02750177
114membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.02427917
115negative regulation of epidermal cell differentiation (GO:0045605)3.01156796
116cellular response to pH (GO:0071467)3.00792508
117bile acid metabolic process (GO:0008206)3.00006009
118glycerol metabolic process (GO:0006071)2.99772797
119keratinocyte proliferation (GO:0043616)2.98001724
120positive regulation of glycoprotein metabolic process (GO:1903020)2.97921184
121eosinophil chemotaxis (GO:0048245)2.97119950
122tight junction assembly (GO:0070830)2.96040842
123disruption of cells of other organism (GO:0044364)2.95293257
124killing of cells of other organism (GO:0031640)2.95293257
125phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.92561433
126fat-soluble vitamin metabolic process (GO:0006775)2.92381787
127sodium ion homeostasis (GO:0055078)2.91831404
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91677390
129glycolipid catabolic process (GO:0019377)2.91265714
130modified amino acid transport (GO:0072337)2.91055578
131positive regulation of cGMP metabolic process (GO:0030825)2.89859190
132drinking behavior (GO:0042756)2.89857529
133antimicrobial humoral response (GO:0019730)2.89601541
134diterpenoid biosynthetic process (GO:0016102)2.89347327
135phospholipid scrambling (GO:0017121)2.85160854
136regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84737476
137branching involved in labyrinthine layer morphogenesis (GO:0060670)2.81397064
138hemidesmosome assembly (GO:0031581)2.81292014
139muscle atrophy (GO:0014889)2.80146166
140regulation of cholesterol homeostasis (GO:2000188)2.77748040
141sulfur amino acid catabolic process (GO:0000098)2.76995658
142hair cell differentiation (GO:0035315)2.75254014
143somite development (GO:0061053)2.74756524
144negative regulation of sodium ion transport (GO:0010766)2.71689679
145pyrimidine-containing compound transmembrane transport (GO:0072531)2.70587796
146respiratory tube development (GO:0030323)2.70305838
147regulation of cardioblast differentiation (GO:0051890)2.67941502
148embryonic digestive tract development (GO:0048566)2.67582837
149establishment of epithelial cell polarity (GO:0090162)2.67547202
150nucleotide transmembrane transport (GO:1901679)2.67509158
151lipid translocation (GO:0034204)2.64645732
152phospholipid translocation (GO:0045332)2.64645732
153positive regulation of pseudopodium assembly (GO:0031274)2.64361746
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.63436233
155phosphate ion transmembrane transport (GO:0035435)2.62616819
156inner ear receptor cell differentiation (GO:0060113)2.62571084
157inner ear receptor cell development (GO:0060119)2.61723480
158membrane repolarization during action potential (GO:0086011)2.60490634
159trophectodermal cell differentiation (GO:0001829)2.60052704
160thyroid hormone metabolic process (GO:0042403)2.59910642
161negative regulation of cell fate commitment (GO:0010454)2.55931879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.89193412
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.30727678
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.83487615
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.48458879
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.25714247
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.16152422
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.13032306
8EZH2_22144423_ChIP-Seq_EOC_Human3.05370968
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81622222
10SOX2_20726797_ChIP-Seq_SW620_Human2.71369503
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.50803360
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43585867
13GATA4_25053715_ChIP-Seq_YYC3_Human2.27677563
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.14276475
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13686363
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09464935
17GATA6_25053715_ChIP-Seq_YYC3_Human2.02376557
18PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.95127330
19DROSHA_22980978_ChIP-Seq_HELA_Human1.85394544
20VDR_22108803_ChIP-Seq_LS180_Human1.84016167
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.79451782
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77407413
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.77052302
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70571994
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66377913
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.64619422
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63536190
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62866740
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62636005
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.61277614
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60284218
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58463954
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.55395167
34KLF5_25053715_ChIP-Seq_YYC3_Human1.55228630
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.54003357
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53714526
37BCAT_22108803_ChIP-Seq_LS180_Human1.46606837
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.42792285
39CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38940817
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.37685442
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37638378
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36912932
43* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36435874
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36052710
45LXR_22292898_ChIP-Seq_THP-1_Human1.35908011
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.35424444
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34944107
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34653845
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31942304
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31791254
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30543599
52CDX2_22108803_ChIP-Seq_LS180_Human1.29605647
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27613886
54CLOCK_20551151_ChIP-Seq_293T_Human1.26022967
55* CBX2_27304074_Chip-Seq_ESCs_Mouse1.25126491
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.24951133
57* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23720885
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22548482
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22543288
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20446139
61CTCF_27219007_Chip-Seq_Bcells_Human1.19819690
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.19515008
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19323789
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19034574
65EGR1_19032775_ChIP-ChIP_M12_Human1.18386975
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16882179
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16414568
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16130111
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16119356
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15606553
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.13587204
72NANOG_20526341_ChIP-Seq_ESCs_Human1.11928833
73AR_21909140_ChIP-Seq_LNCAP_Human1.10417493
74SA1_27219007_Chip-Seq_Bcells_Human1.10154715
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09544519
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09465948
77* EZH2_27294783_Chip-Seq_ESCs_Mouse1.06995693
78* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06092450
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.05759641
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04921578
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04795187
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04795187
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04753106
84TP53_18474530_ChIP-ChIP_U2OS_Human1.04488816
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04245838
86RACK7_27058665_Chip-Seq_MCF-7_Human1.04096634
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.03222194
88* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02425699
89* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02425699
90AHR_22903824_ChIP-Seq_MCF-7_Human1.02299026
91* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01944340
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99698646
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.98878229
94FOXA2_19822575_ChIP-Seq_HepG2_Human0.98816086
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97864165
96TP53_16413492_ChIP-PET_HCT116_Human0.96226311
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96019505
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95644489
99CJUN_26792858_Chip-Seq_BT549_Human0.95285751
100* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94493795
101* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94127055
102* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94028868
103PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93647625
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92108971
105GATA2_19941826_ChIP-Seq_K562_Human0.91875494
106VDR_24787735_ChIP-Seq_THP-1_Human0.91841414
107RXR_22108803_ChIP-Seq_LS180_Human0.90167343
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89074605
109GATA1_26923725_Chip-Seq_HPCs_Mouse0.88918071
110* RING1B_27294783_Chip-Seq_ESCs_Mouse0.88594303
111KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88323220
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88053389
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87521464
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86743617
115* TCF4_22108803_ChIP-Seq_LS180_Human0.86500228
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86371669
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.86361843
118* EED_16625203_ChIP-ChIP_MESCs_Mouse0.86323051
119MYC_27129775_Chip-Seq_CORNEA_Mouse0.86001097
120* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85835411
121SOX2_22085726_ChIP-Seq_NPCs_Mouse0.85652639
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85267123
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85163863
124CEBPB_22108803_ChIP-Seq_LS180_Human0.85073050
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84746465
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84672939
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.84613419
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84487856
129STAT1_20625510_ChIP-Seq_HELA_Human0.84241748
130* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.83796608
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83730780
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83649976
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83410998
134* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83231374
135* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83000922
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.82964639
137BCL6_27268052_Chip-Seq_Bcells_Human0.82879560
138* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81921538
139CREB1_26743006_Chip-Seq_LNCaP_Human0.81784732
140STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.81723475
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81112000
142* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80730608
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.80535919
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.80441547
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79483911
146* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.78684274
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78663550
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78426158
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78295875
150* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77936409
151HNF4A_19822575_ChIP-Seq_HepG2_Human0.77585144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.12852727
2MP0010234_abnormal_vibrissa_follicle5.02813409
3MP0000462_abnormal_digestive_system4.61421623
4MP0001666_abnormal_nutrient_absorption4.55607589
5MP0005377_hearing/vestibular/ear_phenot4.25681306
6MP0003878_abnormal_ear_physiology4.25681306
7MP0003866_abnormal_defecation4.03184168
8MP0004264_abnormal_extraembryonic_tissu3.08231972
9MP0000537_abnormal_urethra_morphology2.89057524
10MP0005381_digestive/alimentary_phenotyp2.86986505
11MP0001485_abnormal_pinna_reflex2.83614975
12MP0001663_abnormal_digestive_system2.68528530
13MP0003705_abnormal_hypodermis_morpholog2.37164565
14* MP0010155_abnormal_intestine_physiology2.31854173
15MP0005085_abnormal_gallbladder_physiolo2.26539739
16MP0001873_stomach_inflammation2.22537685
17MP0001664_abnormal_digestion2.21080642
18MP0010352_gastrointestinal_tract_polyps2.17651606
19MP0009379_abnormal_foot_pigmentation2.15031118
20MP0003879_abnormal_hair_cell2.14324717
21* MP0000477_abnormal_intestine_morphology2.09232659
22MP0003868_abnormal_feces_composition2.08293873
23MP0006054_spinal_hemorrhage2.06190960
24MP0005187_abnormal_penis_morphology2.01620545
25MP0002638_abnormal_pupillary_reflex1.90448318
26MP0002822_catalepsy1.89156082
27MP0004134_abnormal_chest_morphology1.83941734
28MP0004147_increased_porphyrin_level1.81917191
29MP0001188_hyperpigmentation1.77645051
30* MP0000490_abnormal_crypts_of1.66348410
31MP0005670_abnormal_white_adipose1.63659009
32MP0003252_abnormal_bile_duct1.60761570
33MP0008875_abnormal_xenobiotic_pharmacok1.60306213
34MP0004858_abnormal_nervous_system1.58054985
35MP0010386_abnormal_urinary_bladder1.57650271
36MP0005167_abnormal_blood-brain_barrier1.57464652
37MP0001764_abnormal_homeostasis1.56174055
38MP0000538_abnormal_urinary_bladder1.52237373
39MP0003183_abnormal_peptide_metabolism1.47559408
40MP0002138_abnormal_hepatobiliary_system1.44377441
41MP0010678_abnormal_skin_adnexa1.37445455
42MP0000467_abnormal_esophagus_morphology1.37366714
43MP0005332_abnormal_amino_acid1.35208179
44MP0004043_abnormal_pH_regulation1.32736494
45MP0000566_synostosis1.29029061
46MP0001756_abnormal_urination1.27562719
47MP0005409_darkened_coat_color1.21763352
48MP0005503_abnormal_tendon_morphology1.21263207
49MP0005365_abnormal_bile_salt1.20377017
50MP0003938_abnormal_ear_development1.19332102
51MP0000613_abnormal_salivary_gland1.15608086
52MP0001501_abnormal_sleep_pattern1.14867203
53MP0000465_gastrointestinal_hemorrhage1.13988806
54MP0003300_gastrointestinal_ulcer1.12657052
55MP0002139_abnormal_hepatobiliary_system1.10840847
56MP0009384_cardiac_valve_regurgitation1.08771514
57MP0003315_abnormal_perineum_morphology1.08478985
58MP0001963_abnormal_hearing_physiology1.07654304
59MP0005166_decreased_susceptibility_to1.07177836
60MP0003806_abnormal_nucleotide_metabolis1.06680482
61MP0009780_abnormal_chondrocyte_physiolo1.05640059
62MP0002136_abnormal_kidney_physiology1.05607835
63MP0005645_abnormal_hypothalamus_physiol1.05504813
64MP0005257_abnormal_intraocular_pressure1.05405640
65MP0000230_abnormal_systemic_arterial1.04131114
66MP0002277_abnormal_respiratory_mucosa1.02849025
67MP0003283_abnormal_digestive_organ1.02504767
68MP0010329_abnormal_lipoprotein_level1.02177698
69* MP0000026_abnormal_inner_ear1.01615102
70MP0004270_analgesia1.00540855
71MP0000678_abnormal_parathyroid_gland0.98218552
72MP0004019_abnormal_vitamin_homeostasis0.97624735
73MP0002118_abnormal_lipid_homeostasis0.97106292
74MP0003385_abnormal_body_wall0.95258340
75MP0000470_abnormal_stomach_morphology0.94940891
76MP0002938_white_spotting0.94520716
77MP0008438_abnormal_cutaneous_collagen0.91950571
78MP0005448_abnormal_energy_balance0.91701298
79MP0001849_ear_inflammation0.91661190
80MP0004272_abnormal_basement_membrane0.91346280
81MP0004742_abnormal_vestibular_system0.91302775
82MP0002971_abnormal_brown_adipose0.89751647
83MP0010030_abnormal_orbit_morphology0.88641945
84MP0002896_abnormal_bone_mineralization0.86494434
85MP0000762_abnormal_tongue_morphology0.85997205
86MP0004782_abnormal_surfactant_physiolog0.83954988
87MP0003718_maternal_effect0.83558126
88MP0001765_abnormal_ion_homeostasis0.81362471
89MP0003690_abnormal_glial_cell0.79995573
90MP0003941_abnormal_skin_development0.78665605
91MP0002796_impaired_skin_barrier0.77060880
92MP0005535_abnormal_body_temperature0.76160893
93MP0003950_abnormal_plasma_membrane0.74927763
94MP0005584_abnormal_enzyme/coenzyme_acti0.74292564
95MP0005248_abnormal_Harderian_gland0.73510667
96MP0001486_abnormal_startle_reflex0.72837117
97MP0002098_abnormal_vibrissa_morphology0.72809285
98MP0002249_abnormal_larynx_morphology0.71486819
99MP0002060_abnormal_skin_morphology0.69425394
100MP0002089_abnormal_postnatal_growth/wei0.68778307
101* MP0009642_abnormal_blood_homeostasis0.67793951
102MP0000609_abnormal_liver_physiology0.67107202
103MP0005174_abnormal_tail_pigmentation0.66554160
104MP0001845_abnormal_inflammatory_respons0.65948915
105MP0004484_altered_response_of0.64080390
106MP0005310_abnormal_salivary_gland0.64058268
107MP0003953_abnormal_hormone_level0.63638832
108MP0005319_abnormal_enzyme/_coenzyme0.63510448
109MP0009250_abnormal_appendicular_skeleto0.62096426
110MP0001299_abnormal_eye_distance/0.59471489
111MP0002069_abnormal_eating/drinking_beha0.58573990
112MP0003937_abnormal_limbs/digits/tail_de0.58258466
113MP0005636_abnormal_mineral_homeostasis0.57551354
114MP0003724_increased_susceptibility_to0.57127492
115MP0008872_abnormal_physiological_respon0.56225848
116MP0000516_abnormal_urinary_system0.55790401
117MP0005367_renal/urinary_system_phenotyp0.55790401
118MP0001243_abnormal_dermal_layer0.52137749
119MP0005025_abnormal_response_to0.51187367
120MP0006276_abnormal_autonomic_nervous0.51187352
121MP0003638_abnormal_response/metabolism_0.50189358
122MP0009840_abnormal_foam_cell0.50056035
123MP0008789_abnormal_olfactory_epithelium0.49817985
124MP0005666_abnormal_adipose_tissue0.49689176
125MP0003453_abnormal_keratinocyte_physiol0.48505600
126MP0000647_abnormal_sebaceous_gland0.48326592
127MP0002233_abnormal_nose_morphology0.48074646
128MP0008469_abnormal_protein_level0.46987902
129MP0009785_altered_susceptibility_to0.46961956
130MP0001216_abnormal_epidermal_layer0.46438932
131MP0002876_abnormal_thyroid_physiology0.44995206
132MP0000377_abnormal_hair_follicle0.44353461
133MP0009643_abnormal_urine_homeostasis0.43965491
134MP0005501_abnormal_skin_physiology0.43681350
135MP0003115_abnormal_respiratory_system0.43017067
136MP0005451_abnormal_body_composition0.42463051
137MP0002734_abnormal_mechanical_nocicepti0.42154642
138MP0005334_abnormal_fat_pad0.40364019
139MP0000249_abnormal_blood_vessel0.40305027
140MP0002909_abnormal_adrenal_gland0.39611706
141MP0001881_abnormal_mammary_gland0.38617236
142MP0009115_abnormal_fat_cell0.38267324
143MP0002078_abnormal_glucose_homeostasis0.37781580
144MP0002132_abnormal_respiratory_system0.36770961

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)6.94201049
2Decreased circulating renin level (HP:0003351)6.35237249
3Right ventricular cardiomyopathy (HP:0011663)5.63189315
4Short 4th metacarpal (HP:0010044)5.23369294
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.23369294
6Abnormality of the distal phalanx of the thumb (HP:0009617)5.04196668
7Alkalosis (HP:0001948)4.61957590
8Congenital sensorineural hearing impairment (HP:0008527)4.36725233
9Short phalanx of the thumb (HP:0009660)4.26393119
10Glycosuria (HP:0003076)4.24245206
11Abnormality of urine glucose concentration (HP:0011016)4.24245206
12Chronic diarrhea (HP:0002028)4.16617959
13Down-sloping shoulders (HP:0200021)4.04450462
14Milia (HP:0001056)4.01627992
15Mildly elevated creatine phosphokinase (HP:0008180)3.89953612
16Neoplasm of the heart (HP:0100544)3.84873162
17Metabolic alkalosis (HP:0200114)3.82901190
18Abnormality of the 4th metacarpal (HP:0010012)3.79194570
19Abdominal distention (HP:0003270)3.76721269
20Malnutrition (HP:0004395)3.74255643
21Flat acetabular roof (HP:0003180)3.74021256
22Conjugated hyperbilirubinemia (HP:0002908)3.73081657
23Abnormal hand bone ossification (HP:0010660)3.71125080
24Systemic lupus erythematosus (HP:0002725)3.69408291
25Abnormal ossification of hand bones (HP:0005921)3.64701037
26Hyperactive renin-angiotensin system (HP:0000841)3.64222856
27Confusion (HP:0001289)3.56568542
28Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.39797683
29Abnormality of vitamin metabolism (HP:0100508)3.39642851
30Abnormality of the nasal septum (HP:0000419)3.39166750
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.33639402
32Hyperaldosteronism (HP:0000859)3.32523957
33Hyperuricemia (HP:0002149)3.28103563
34Increased purine levels (HP:0004368)3.28103563
35Cupped ribs (HP:0000887)3.25282735
36Hyperphosphaturia (HP:0003109)3.23799107
37Pigmentary retinal degeneration (HP:0001146)3.07031127
38Abnormal tarsal ossification (HP:0008369)3.04649842
39Progressive sensorineural hearing impairment (HP:0000408)3.01974612
40Proximal tubulopathy (HP:0000114)2.98382462
41Hyperglycinuria (HP:0003108)2.95440118
42Abnormal urine phosphate concentration (HP:0012599)2.94484603
43Nausea (HP:0002018)2.92683664
44Partial duplication of thumb phalanx (HP:0009944)2.82471500
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.79300953
46Gastrointestinal dysmotility (HP:0002579)2.75092557
47Xanthomatosis (HP:0000991)2.73955262
48Abnormal foot bone ossification (HP:0010675)2.71451257
49Potter facies (HP:0002009)2.66889904
50Facial shape deformation (HP:0011334)2.66889904
51Abnormality of the 1st metacarpal (HP:0010009)2.62175424
52Acanthocytosis (HP:0001927)2.62125427
53Abnormality of carpal bone ossification (HP:0006257)2.59493209
54Late onset (HP:0003584)2.58802859
55Micronodular cirrhosis (HP:0001413)2.57539099
56Hyperparathyroidism (HP:0000843)2.56698203
57Nephrolithiasis (HP:0000787)2.55628081
58Hyponatremia (HP:0002902)2.52752621
59Abnormality of glycine metabolism (HP:0010895)2.51826919
60Abnormality of serine family amino acid metabolism (HP:0010894)2.51826919
61Megaloblastic anemia (HP:0001889)2.49386640
62Renal tubular dysfunction (HP:0000124)2.48967147
63Abnormality of purine metabolism (HP:0004352)2.48437073
64Hydroureter (HP:0000072)2.48068868
65Neonatal short-limb short stature (HP:0008921)2.45359317
66Partial duplication of the phalanx of hand (HP:0009999)2.44915733
67Hemorrhage of the eye (HP:0011885)2.44709130
68Hypobetalipoproteinemia (HP:0003563)2.41440975
69Gout (HP:0001997)2.38865416
70Atrophic scars (HP:0001075)2.38479142
71Abnormal biliary tract morphology (HP:0012440)2.38323604
72Urethral obstruction (HP:0000796)2.36504141
73Fat malabsorption (HP:0002630)2.35060901
74Abnormality of proline metabolism (HP:0010907)2.34127527
75Hydroxyprolinuria (HP:0003080)2.34127527
76Abnormality of the parietal bone (HP:0002696)2.33097518
77Abnormality of chloride homeostasis (HP:0011422)2.31023407
78Hyperammonemia (HP:0001987)2.30810599
79Focal segmental glomerulosclerosis (HP:0000097)2.28844180
80Renal tubular acidosis (HP:0001947)2.26794977
81Abnormality of potassium homeostasis (HP:0011042)2.24687113
82Abnormality of magnesium homeostasis (HP:0004921)2.20691779
83Abnormality of small intestinal villus morphology (HP:0011472)2.20453384
84Villous atrophy (HP:0011473)2.20453384
85Intrahepatic cholestasis (HP:0001406)2.19139544
86Supernumerary ribs (HP:0005815)2.19100231
87Aortic aneurysm (HP:0004942)2.17203472
88Hypotension (HP:0002615)2.15331237
89Metabolic acidosis (HP:0001942)2.13901270
90Increased hepatocellular lipid droplets (HP:0006565)2.12921325
91Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.12605462
92Abnormality of nucleobase metabolism (HP:0010932)2.12597052
93Syncope (HP:0001279)2.12073307
94Abnormality of renin-angiotensin system (HP:0000847)2.10429216
95Rectal prolapse (HP:0002035)2.09569634
96Abnormality of the vitamin B12 metabolism (HP:0004341)2.08555752
97Lipid accumulation in hepatocytes (HP:0006561)2.05306173
98Macrocytic anemia (HP:0001972)2.05293796
99Cerebral palsy (HP:0100021)2.04945709
100Abnormality of the gastric mucosa (HP:0004295)2.04886401
101Progressive hearing impairment (HP:0001730)2.04573135
102Aortic dissection (HP:0002647)2.03524317
103Pili torti (HP:0003777)2.02838045
104Pancreatitis (HP:0001733)2.00785032
105Woolly hair (HP:0002224)2.00714979
106Large earlobe (HP:0009748)2.00322009
107Hypophosphatemia (HP:0002148)1.99951266
108Mesangial abnormality (HP:0001966)1.99649164
109Delayed CNS myelination (HP:0002188)1.98597572
110Symptomatic seizures (HP:0011145)1.97049637
111Dehydration (HP:0001944)1.95619342
112Gastrointestinal carcinoma (HP:0002672)1.92123934
113Malignant gastrointestinal tract tumors (HP:0006749)1.92123934
114Abnormality of the diencephalon (HP:0010662)1.90927454
115Biliary tract neoplasm (HP:0100574)1.90630640
116Uterine neoplasm (HP:0010784)1.89378942
117Supernumerary bones of the axial skeleton (HP:0009144)1.88884124
118Flattened epiphyses (HP:0003071)1.88667703
119Ureteral obstruction (HP:0006000)1.88091995
120Abnormality of vitamin B metabolism (HP:0004340)1.86907449
121Thin bony cortex (HP:0002753)1.86173762
122Dicarboxylic aciduria (HP:0003215)1.85752637
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85752637
124Steatorrhea (HP:0002570)1.83745675
125Abnormality of sodium homeostasis (HP:0010931)1.83694229
126Abnormal glucose tolerance (HP:0001952)1.83676227
127Midline defect of the nose (HP:0004122)1.83351570
128Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83106401
129Short 1st metacarpal (HP:0010034)1.83106401
130Widely patent fontanelles and sutures (HP:0004492)1.82231149
131Bone cyst (HP:0012062)1.80498851
132Eczematoid dermatitis (HP:0000976)1.78541715
133Medulloblastoma (HP:0002885)1.77989508
134Irritability (HP:0000737)1.77061649
135Abnormality of the phalanges of the hallux (HP:0010057)1.76098106
136Glomerulonephritis (HP:0000099)1.75437554
137Palpitations (HP:0001962)1.75407494
138Adrenal overactivity (HP:0002717)1.75334255
139Abnormal auditory evoked potentials (HP:0006958)1.75060685
140Arterial tortuosity (HP:0005116)1.74853232
141Symphalangism affecting the phalanges of the hand (HP:0009773)1.74402939
142Abnormal cartilage morphology (HP:0002763)1.73574547
143Chin dimple (HP:0010751)1.71805166
144Ventricular fibrillation (HP:0001663)1.71415469
145Fragile skin (HP:0001030)1.70959753
146Limb-girdle muscle atrophy (HP:0003797)1.70877891
147Hyperphosphatemia (HP:0002905)1.70483898
148Abnormal hair laboratory examination (HP:0003328)1.69782976
149Bundle branch block (HP:0011710)1.69759712
150Germ cell neoplasia (HP:0100728)1.68095856
151Increased muscle lipid content (HP:0009058)1.67965479
152Wide cranial sutures (HP:0010537)1.67627532
153Autoimmune thrombocytopenia (HP:0001973)1.66970692
154Stomach cancer (HP:0012126)1.66883171
155Hypolipoproteinemia (HP:0010981)1.66668915
156Short ribs (HP:0000773)1.65739922
157Ovarian neoplasm (HP:0100615)1.65659016
158Myopathic facies (HP:0002058)1.65536666
159Renal Fanconi syndrome (HP:0001994)1.65165706
160Hypokalemia (HP:0002900)1.65068765
161Skin pits (HP:0100276)1.64226794
162Hoarse voice (HP:0001609)1.61747150
163Hamartoma (HP:0010566)1.60430806
164Curly hair (HP:0002212)1.60231494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.07101549
2ACVR1B6.16172158
3LMTK24.02302137
4EPHB23.14497279
5MST43.12132198
6EPHA33.04836993
7MST1R2.92502426
8STK392.82965738
9CASK2.51408104
10STK242.47145471
11PTK62.44678757
12PIK3CA2.38410116
13MAP3K22.17546909
14MAP2K22.14760699
15RIPK12.10898920
16TESK22.04109471
17DDR21.96286932
18PRKG21.92842921
19MYLK1.92824220
20EEF2K1.84357360
21NUAK11.82841043
22LIMK11.80817259
23PRKCI1.74440334
24MET1.70006551
25TESK11.69444846
26NME11.67778353
27ERBB21.67127387
28PBK1.55844565
29LATS11.53481530
30WNK41.52108773
31GRK61.49916943
32WNK31.45676850
33FGFR41.37031684
34MAP3K121.32186164
35ICK1.24859967
36CAMK1D1.23171425
37PRPF4B1.21665914
38MAP3K101.20881343
39EPHA21.18806281
40PDGFRA1.10159778
41EPHB11.07571996
42FGFR21.05471006
43TNIK1.03710464
44PDK20.96440435
45PAK40.92260107
46PDGFRB0.87732312
47FER0.87233698
48PTK2B0.83552291
49RPS6KB20.81585230
50PRKCZ0.78494426
51KSR20.77185350
52CSK0.75964298
53MAP2K10.75623078
54TTK0.74146159
55ROCK20.73519072
56ADRBK20.72903244
57PRKAA20.72021294
58STK100.70810601
59PAK20.70189406
60TYK20.69184194
61RPS6KA40.68675616
62PAK30.67394742
63PTK20.65257925
64PRKACG0.64414066
65DYRK30.64334889
66TYRO30.63406044
67ROCK10.62981113
68BMX0.62702770
69KSR10.62481945
70CAMK1G0.62254604
71CDC42BPA0.60951328
72OXSR10.60888799
73MAP4K10.60645766
74AKT30.59537764
75CSNK1A1L0.58975883
76DYRK1B0.58395671
77DMPK0.58330275
78MAP3K80.58255461
79TLK10.56933959
80PDK10.55375051
81STK30.55155109
82PIM20.55134016
83EPHA40.55028146
84YES10.54959614
85GRK10.54908691
86LRRK20.54172106
87AURKB0.53616723
88MAPK110.52833684
89PDPK10.52694833
90RET0.50869910
91PRKAA10.50687975
92TXK0.49761595
93CDK60.49760157
94CAMK2D0.49674108
95CAMK2B0.47819892
96MINK10.47464964
97CSNK1G30.47387810
98MAP3K90.47382402
99TTN0.45127740
100UHMK10.44383581
101ZAK0.43898552
102MATK0.43601777
103NLK0.43370695
104PAK10.42512421
105TRPM70.42346421
106FYN0.42276400
107CAMK2G0.39737263
108ILK0.38963210
109CSNK1G10.36974787
110LYN0.34339858
111SIK10.33984746
112MAP2K40.33785564
113FGR0.33685731
114ALK0.33602735
115SRC0.33596229
116ERN10.32803123
117SGK4940.31310246
118SGK2230.31310246
119ARAF0.30126211
120IKBKE0.29992600
121PRKACA0.29282224
122INSR0.29084951
123CSNK1E0.28721760
124MAP3K70.28580858
125MAP2K60.28446630
126PRKCA0.27746456
127PRKCQ0.27477381
128MAP3K40.27346101
129STK160.27043891
130MAP3K110.25241230
131PKN20.24912039
132RPS6KA20.24647189
133CSNK1G20.24556371
134FGFR30.24030817
135RAF10.23688280
136FLT30.23238231
137PRKCD0.23228661
138CSNK1A10.23154638
139PRKCB0.22582302
140MAPK40.22083180
141MAP3K10.21839827
142MAP2K70.21746245
143DAPK30.21562864
144PRKG10.21069598
145NEK60.20982883
146MAPKAPK20.20879669
147DAPK20.19828756

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049784.82156911
2Sulfur metabolism_Homo sapiens_hsa009204.50693680
3Fat digestion and absorption_Homo sapiens_hsa049753.60887631
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.31163086
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.04831254
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.84464374
7Renin-angiotensin system_Homo sapiens_hsa046142.73967288
8Histidine metabolism_Homo sapiens_hsa003402.44833558
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30454010
10Protein digestion and absorption_Homo sapiens_hsa049742.27328257
11Bile secretion_Homo sapiens_hsa049762.22297687
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.15263528
13Arginine biosynthesis_Homo sapiens_hsa002202.02958852
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02936780
15Vitamin digestion and absorption_Homo sapiens_hsa049771.91002911
16Galactose metabolism_Homo sapiens_hsa000521.87359022
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.77725310
18Starch and sucrose metabolism_Homo sapiens_hsa005001.77657590
19Tight junction_Homo sapiens_hsa045301.60047065
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59544935
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59366887
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.56210061
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.49083101
24Basal cell carcinoma_Homo sapiens_hsa052171.46159263
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36075381
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28772317
27Glutathione metabolism_Homo sapiens_hsa004801.21124224
28Tryptophan metabolism_Homo sapiens_hsa003801.15749438
29Asthma_Homo sapiens_hsa053101.15342590
30Fatty acid degradation_Homo sapiens_hsa000711.13703262
31Fructose and mannose metabolism_Homo sapiens_hsa000511.10847878
32Caffeine metabolism_Homo sapiens_hsa002321.09519978
33Phenylalanine metabolism_Homo sapiens_hsa003601.06515773
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05797940
35Thyroid hormone synthesis_Homo sapiens_hsa049181.00282739
36Pancreatic secretion_Homo sapiens_hsa049720.99778545
37ABC transporters_Homo sapiens_hsa020100.97875387
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.96366848
39Adherens junction_Homo sapiens_hsa045200.92812206
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92197448
41Arginine and proline metabolism_Homo sapiens_hsa003300.92076968
42Amoebiasis_Homo sapiens_hsa051460.90898275
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90488498
44Sphingolipid metabolism_Homo sapiens_hsa006000.88487465
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87609492
46PPAR signaling pathway_Homo sapiens_hsa033200.86940959
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86860785
48Hedgehog signaling pathway_Homo sapiens_hsa043400.86723957
49African trypanosomiasis_Homo sapiens_hsa051430.83371291
50Glycerolipid metabolism_Homo sapiens_hsa005610.83347688
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81340784
52beta-Alanine metabolism_Homo sapiens_hsa004100.81036638
53Thyroid cancer_Homo sapiens_hsa052160.78104785
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77905658
55Vibrio cholerae infection_Homo sapiens_hsa051100.77343606
56Systemic lupus erythematosus_Homo sapiens_hsa053220.77027623
57Salmonella infection_Homo sapiens_hsa051320.74198974
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73664190
59Renin secretion_Homo sapiens_hsa049240.73164227
60Allograft rejection_Homo sapiens_hsa053300.70869857
61Axon guidance_Homo sapiens_hsa043600.70324204
62Gastric acid secretion_Homo sapiens_hsa049710.66971647
63Staphylococcus aureus infection_Homo sapiens_hsa051500.66912888
64Cocaine addiction_Homo sapiens_hsa050300.66781242
65Autoimmune thyroid disease_Homo sapiens_hsa053200.66503488
66Folate biosynthesis_Homo sapiens_hsa007900.66054132
67ECM-receptor interaction_Homo sapiens_hsa045120.65741354
68Butanoate metabolism_Homo sapiens_hsa006500.65081875
69Oxidative phosphorylation_Homo sapiens_hsa001900.64778735
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64587496
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64393997
72Graft-versus-host disease_Homo sapiens_hsa053320.64286000
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62970980
74N-Glycan biosynthesis_Homo sapiens_hsa005100.61182132
75Salivary secretion_Homo sapiens_hsa049700.58492541
76Chemical carcinogenesis_Homo sapiens_hsa052040.58383649
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57940579
78Peroxisome_Homo sapiens_hsa041460.57284502
79Hepatitis C_Homo sapiens_hsa051600.57085245
80Gap junction_Homo sapiens_hsa045400.54402774
81Fatty acid biosynthesis_Homo sapiens_hsa000610.53618352
82Retinol metabolism_Homo sapiens_hsa008300.51901985
83Endometrial cancer_Homo sapiens_hsa052130.50214093
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49519833
85Bladder cancer_Homo sapiens_hsa052190.48672312
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.48067244
87Propanoate metabolism_Homo sapiens_hsa006400.45738660
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.44392955
89Arachidonic acid metabolism_Homo sapiens_hsa005900.43608737
90Parkinsons disease_Homo sapiens_hsa050120.43276255
91Type I diabetes mellitus_Homo sapiens_hsa049400.42579282
92Cardiac muscle contraction_Homo sapiens_hsa042600.40817477
93Alcoholism_Homo sapiens_hsa050340.40354875
94GnRH signaling pathway_Homo sapiens_hsa049120.39277480
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.38830245
96Sulfur relay system_Homo sapiens_hsa041220.37405172
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.37317228
98Lysine degradation_Homo sapiens_hsa003100.36934896
99Alzheimers disease_Homo sapiens_hsa050100.36847460
100Fatty acid metabolism_Homo sapiens_hsa012120.34904388
101Focal adhesion_Homo sapiens_hsa045100.34743642
102Type II diabetes mellitus_Homo sapiens_hsa049300.32002053
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31730527
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31588803
105Selenocompound metabolism_Homo sapiens_hsa004500.31485156
106Hippo signaling pathway_Homo sapiens_hsa043900.30878804
107Proteoglycans in cancer_Homo sapiens_hsa052050.30528772
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28442547
109Serotonergic synapse_Homo sapiens_hsa047260.28201775
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28187732
111Ether lipid metabolism_Homo sapiens_hsa005650.28118527
112Metabolic pathways_Homo sapiens_hsa011000.27716148
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27611797
114Huntingtons disease_Homo sapiens_hsa050160.26790195
115Linoleic acid metabolism_Homo sapiens_hsa005910.26459184
116Amphetamine addiction_Homo sapiens_hsa050310.26142637
117MicroRNAs in cancer_Homo sapiens_hsa052060.25825736
118Nitrogen metabolism_Homo sapiens_hsa009100.25657210
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25136982
120Antigen processing and presentation_Homo sapiens_hsa046120.24455129
121Insulin secretion_Homo sapiens_hsa049110.23949332
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23682389
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23187044
124Small cell lung cancer_Homo sapiens_hsa052220.22999328
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20773293
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20596341
127Pertussis_Homo sapiens_hsa051330.20166585
128Tyrosine metabolism_Homo sapiens_hsa003500.19790671
129Leishmaniasis_Homo sapiens_hsa051400.19635473
130Pyruvate metabolism_Homo sapiens_hsa006200.19026319
131Cholinergic synapse_Homo sapiens_hsa047250.17155021
132Other glycan degradation_Homo sapiens_hsa005110.16603348
133Choline metabolism in cancer_Homo sapiens_hsa052310.16535274
134Glucagon signaling pathway_Homo sapiens_hsa049220.16365358
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.16165006
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.12755278
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08719071
138Insulin resistance_Homo sapiens_hsa049310.07701515

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