ATOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)6.31416627
2chaperone-mediated protein transport (GO:0072321)6.00716823
3protein complex biogenesis (GO:0070271)5.73832304
4ribosomal small subunit biogenesis (GO:0042274)5.34100622
5mitochondrial respiratory chain complex assembly (GO:0033108)5.31144817
6mitochondrial respiratory chain complex I assembly (GO:0032981)5.09618520
7NADH dehydrogenase complex assembly (GO:0010257)5.09618520
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.09618520
9viral transcription (GO:0019083)5.06821764
10neutrophil activation involved in immune response (GO:0002283)4.95019822
11hydrogen ion transmembrane transport (GO:1902600)4.81829652
12translational termination (GO:0006415)4.79580846
13ribosomal small subunit assembly (GO:0000028)4.72431593
14ATP biosynthetic process (GO:0006754)4.42405189
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.35812186
16cotranslational protein targeting to membrane (GO:0006613)4.33437252
17protein targeting to ER (GO:0045047)4.30408974
18regulation of mitochondrial translation (GO:0070129)4.30053831
19proton transport (GO:0015992)4.22129313
20transcription elongation from RNA polymerase III promoter (GO:0006385)4.19542735
21termination of RNA polymerase III transcription (GO:0006386)4.19542735
22purine nucleoside triphosphate biosynthetic process (GO:0009145)4.17403034
23hydrogen transport (GO:0006818)4.15160268
24purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.11954119
25protein localization to endoplasmic reticulum (GO:0070972)4.09752917
26cytochrome complex assembly (GO:0017004)4.06647890
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06133306
28aldehyde catabolic process (GO:0046185)4.05134014
29inner mitochondrial membrane organization (GO:0007007)3.94072418
30respiratory chain complex IV assembly (GO:0008535)3.91478934
31positive regulation of monocyte chemotaxis (GO:0090026)3.86950279
32viral life cycle (GO:0019058)3.86104458
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85236791
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83116579
35ATP synthesis coupled proton transport (GO:0015986)3.83116579
36translational elongation (GO:0006414)3.82886236
37platelet dense granule organization (GO:0060155)3.79193683
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73055668
39cellular protein complex disassembly (GO:0043624)3.63327403
40protein neddylation (GO:0045116)3.61039355
41protein targeting to mitochondrion (GO:0006626)3.58256072
42ribonucleoside triphosphate biosynthetic process (GO:0009201)3.58241016
43establishment of protein localization to mitochondrion (GO:0072655)3.56496164
44water-soluble vitamin biosynthetic process (GO:0042364)3.55854098
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.47944312
46superoxide anion generation (GO:0042554)3.47153887
47protein localization to mitochondrion (GO:0070585)3.46507995
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45820239
49monocyte chemotaxis (GO:0002548)3.45405042
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41076099
51negative regulation of ligase activity (GO:0051352)3.41076099
52hydrogen peroxide biosynthetic process (GO:0050665)3.38053563
53respiratory burst (GO:0045730)3.37903027
54granulocyte activation (GO:0036230)3.33872459
55response to peptidoglycan (GO:0032494)3.33748790
56rRNA modification (GO:0000154)3.32335297
57sequestering of actin monomers (GO:0042989)3.28990142
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28742020
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.28117932
60intracellular protein transmembrane import (GO:0044743)3.27373748
61cellular component biogenesis (GO:0044085)3.26831864
62eosinophil chemotaxis (GO:0048245)3.25627103
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24273958
64nucleoside triphosphate biosynthetic process (GO:0009142)3.23658722
65neutrophil activation (GO:0042119)3.21648244
66mitochondrial transport (GO:0006839)3.21017411
67maturation of SSU-rRNA (GO:0030490)3.19864969
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.18538027
69respiratory electron transport chain (GO:0022904)3.16719859
70response to interferon-beta (GO:0035456)3.11640224
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11012843
72nuclear-transcribed mRNA catabolic process (GO:0000956)3.10386324
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10352734
74ATP hydrolysis coupled proton transport (GO:0015991)3.10352734
75translational initiation (GO:0006413)3.09996981
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08324573
77cullin deneddylation (GO:0010388)3.07804687
78electron transport chain (GO:0022900)3.07782076
79reactive oxygen species biosynthetic process (GO:1903409)3.07485452
80protein-cofactor linkage (GO:0018065)3.06891333
81ribosomal large subunit biogenesis (GO:0042273)3.06639522
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.04579492
83proteasome assembly (GO:0043248)2.99565575
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96732329
85mRNA catabolic process (GO:0006402)2.94590346
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92323312
87establishment of protein localization to membrane (GO:0090150)2.91699356
88eosinophil migration (GO:0072677)2.91639015
89cellular response to zinc ion (GO:0071294)2.91587126
90protein targeting to membrane (GO:0006612)2.90807072
91regulation of oxidative phosphorylation (GO:0002082)2.90739734
92protein targeting (GO:0006605)2.88643581
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.88205266
94purine nucleoside monophosphate biosynthetic process (GO:0009127)2.88205266
95regulation of activation of Janus kinase activity (GO:0010533)2.87636610
967-methylguanosine mRNA capping (GO:0006370)2.87467180
97mannosylation (GO:0097502)2.84202538
98protein deneddylation (GO:0000338)2.82669015
99protein complex disassembly (GO:0043241)2.82258177
100positive regulation of ligase activity (GO:0051351)2.80518125
101oxidative phosphorylation (GO:0006119)2.80228297
102RNA capping (GO:0036260)2.78822068
1037-methylguanosine RNA capping (GO:0009452)2.78822068
104negative regulation of myeloid cell apoptotic process (GO:0033033)2.78277430
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77324280
106lipoxygenase pathway (GO:0019372)2.76900664
107cellular response to interferon-beta (GO:0035458)2.75398103
108translation (GO:0006412)2.75256147
109removal of superoxide radicals (GO:0019430)2.71597314
110cellular response to superoxide (GO:0071451)2.71597314
111cellular response to oxygen radical (GO:0071450)2.71597314
112regulation of monocyte chemotaxis (GO:0090025)2.71330861
113positive regulation of antigen processing and presentation (GO:0002579)2.69149200
114positive regulation of lymphocyte migration (GO:2000403)2.66642680
115antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.65260379
116amyloid precursor protein catabolic process (GO:0042987)2.63098530
117macromolecular complex disassembly (GO:0032984)2.62528012
118regulation of antigen processing and presentation (GO:0002577)2.57833309
119regulation of metalloenzyme activity (GO:0048552)2.56380474
120GTP biosynthetic process (GO:0006183)2.55636550
121positive regulation of T cell migration (GO:2000406)2.55469086
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55066737
123immunoglobulin mediated immune response (GO:0016064)2.53698213
124regulation of cellular amino acid metabolic process (GO:0006521)2.53315011
125DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53148517
126regulation of T-helper 1 cell differentiation (GO:0045625)2.52928080
127regulation of hypersensitivity (GO:0002883)2.52779313
128hydrogen peroxide metabolic process (GO:0042743)2.52230693
129response to muramyl dipeptide (GO:0032495)2.51856323
130regulation of T cell migration (GO:2000404)2.51829924
131positive regulation of interferon-alpha production (GO:0032727)2.48926835
132natural killer cell mediated cytotoxicity (GO:0042267)2.48907830
133natural killer cell mediated immunity (GO:0002228)2.48907830
134fatty acid elongation (GO:0030497)2.48184294
135positive regulation of type 2 immune response (GO:0002830)2.47001226
136myeloid cell homeostasis (GO:0002262)2.44176058
137prostaglandin biosynthetic process (GO:0001516)2.44006405
138prostanoid biosynthetic process (GO:0046457)2.44006405
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43911186
140signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.43743020
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.43743020
142L-ascorbic acid metabolic process (GO:0019852)2.43684253
143negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42963717
144regulation of immunoglobulin secretion (GO:0051023)2.42482591
145signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.41825963
146signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.41825963
147signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.41825963
148regulation of mononuclear cell migration (GO:0071675)2.38473162
149phagosome maturation (GO:0090382)2.34854780
150microglial cell activation (GO:0001774)2.33037032
151regulation of interferon-alpha production (GO:0032647)2.32825468
152positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29024236
153regulation of lymphocyte migration (GO:2000401)2.28429151
154signal transduction involved in DNA integrity checkpoint (GO:0072401)2.26285886
155signal transduction involved in DNA damage checkpoint (GO:0072422)2.26285886
156regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.25437806
157modulation by symbiont of host immune response (GO:0052553)2.25024161
158modulation by symbiont of host defense response (GO:0052031)2.25024161
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25024161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.28776797
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.09144102
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.95792949
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.47621356
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.07537182
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20556241
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09590085
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.93671079
9* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80920268
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80681410
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60945096
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.58676842
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53933577
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43094494
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33615485
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30885690
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22560969
18FOXP3_21729870_ChIP-Seq_TREG_Human2.13925096
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12941988
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.09984092
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04749720
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02168010
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97690058
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93711261
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93530047
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90390856
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89501658
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.89070453
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86636428
30GABP_19822575_ChIP-Seq_HepG2_Human1.80803341
31ELK1_19687146_ChIP-ChIP_HELA_Human1.80026208
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79314140
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78753981
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.78298952
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77668432
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76891157
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75422203
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75422203
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75422203
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74054662
41* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73561244
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.73266463
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72659145
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.70687250
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.69305069
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69055030
47MYC_18940864_ChIP-ChIP_HL60_Human1.65451607
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65272658
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65090710
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56340865
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.53346323
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52069514
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51487683
54CTCF_18555785_ChIP-Seq_MESCs_Mouse1.44655843
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43663941
56SPI1_23547873_ChIP-Seq_NB4_Human1.43507532
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42885808
58DCP1A_22483619_ChIP-Seq_HELA_Human1.39395548
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.38137102
60* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36410124
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36313566
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34479528
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34403943
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34349984
65* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32343637
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30714213
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30339452
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28949504
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27432091
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25557691
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23954191
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23624741
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22954823
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22632724
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20907153
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20030247
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18915704
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18565624
79VDR_23849224_ChIP-Seq_CD4+_Human1.18525218
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18338484
81* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17929801
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15845050
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13879284
84SOX2_20726797_ChIP-Seq_SW620_Human1.12511412
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12335282
86* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12333236
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10188903
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10061509
89STAT1_20625510_ChIP-Seq_HELA_Human1.05498551
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04817953
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03223940
92* RXR_22158963_ChIP-Seq_LIVER_Mouse1.02689513
93XRN2_22483619_ChIP-Seq_HELA_Human1.02394636
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02169077
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99970498
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99858666
97NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99851796
98* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98235658
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97788093
100ERG_20517297_ChIP-Seq_VCAP_Human0.97725236
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97686573
102MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97626737
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97565109
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96789988
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96079559
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96055137
107TFEB_21752829_ChIP-Seq_HELA_Human0.96012513
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95826677
109* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95419433
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95104543
111TTF2_22483619_ChIP-Seq_HELA_Human0.94171890
112NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92205934
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92205934
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91876251
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91390088
116HTT_18923047_ChIP-ChIP_STHdh_Human0.90905256
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90250016
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90076353
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90067392
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90045823
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89858598
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89790332
123ELF5_23300383_ChIP-Seq_T47D_Human0.89568863
124VDR_22108803_ChIP-Seq_LS180_Human0.89529492
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89238751
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88654335
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88110093
128IRF1_19129219_ChIP-ChIP_H3396_Human0.87840140
129E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87825358
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85980098
131* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85390196
132ZNF274_21170338_ChIP-Seq_K562_Hela0.85242183
133EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84931762
134EGR1_19032775_ChIP-ChIP_M12_Human0.84417877
135TP53_22573176_ChIP-Seq_HFKS_Human0.83914969
136FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83120796
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80829097
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.79802410
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79457105
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77577722
141* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75629648
142* FOXA1_25329375_ChIP-Seq_VCAP_Human0.75629648
143* SOX17_20123909_ChIP-Seq_XEN_Mouse0.74665492
144AR_20517297_ChIP-Seq_VCAP_Human0.74628112
145KDM5A_27292631_Chip-Seq_BREAST_Human0.73917202
146MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73380177
147* FOXP1_21924763_ChIP-Seq_HESCs_Human0.73251774
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.68166478
149MYC_19829295_ChIP-Seq_ESCs_Human0.67147175
150NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64866410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.00406211
2MP0001835_abnormal_antigen_presentation3.85887105
3MP0009379_abnormal_foot_pigmentation3.83889957
4MP0002148_abnormal_hypersensitivity_rea3.72642881
5MP0003186_abnormal_redox_activity3.39840933
6MP0009785_altered_susceptibility_to3.28064634
7MP0003436_decreased_susceptibility_to3.14796488
8MP0003724_increased_susceptibility_to3.09556975
9MP0002938_white_spotting2.88111154
10MP0006082_CNS_inflammation2.70774048
11MP0003806_abnormal_nucleotide_metabolis2.46599407
12MP0005025_abnormal_response_to2.43428595
13MP0005000_abnormal_immune_tolerance2.43425413
14MP0002419_abnormal_innate_immunity2.37555450
15MP0010030_abnormal_orbit_morphology2.26827929
16MP0001853_heart_inflammation2.20840227
17MP0004381_abnormal_hair_follicle2.15657082
18MP0003136_yellow_coat_color2.13810326
19MP0002254_reproductive_system_inflammat2.11086168
20MP0005671_abnormal_response_to2.04832385
21MP0006036_abnormal_mitochondrial_physio2.03634024
22MP0002277_abnormal_respiratory_mucosa1.98516620
23MP0006072_abnormal_retinal_apoptosis1.97270866
24MP0000685_abnormal_immune_system1.96129315
25MP0001790_abnormal_immune_system1.93220987
26MP0005387_immune_system_phenotype1.93220987
27MP0009764_decreased_sensitivity_to1.90723280
28MP0002452_abnormal_antigen_presenting1.76759004
29MP0002723_abnormal_immune_serum1.73528967
30MP0001346_abnormal_lacrimal_gland1.72565274
31MP0004142_abnormal_muscle_tone1.71195605
32MP0002796_impaired_skin_barrier1.67964044
33MP0003011_delayed_dark_adaptation1.67368832
34MP0004782_abnormal_surfactant_physiolog1.59501927
35MP0002405_respiratory_system_inflammati1.58443401
36MP0002138_abnormal_hepatobiliary_system1.57320052
37MP0000372_irregular_coat_pigmentation1.56788195
38MP0001533_abnormal_skeleton_physiology1.56148802
39MP0003941_abnormal_skin_development1.55811457
40MP0001800_abnormal_humoral_immune1.52573487
41MP0002132_abnormal_respiratory_system1.49224115
42MP0001819_abnormal_immune_cell1.47756902
43MP0005451_abnormal_body_composition1.47286649
44MP0003195_calcinosis1.44254581
45MP0008469_abnormal_protein_level1.44226407
46MP0009840_abnormal_foam_cell1.44060422
47MP0002420_abnormal_adaptive_immunity1.43844173
48MP0009333_abnormal_splenocyte_physiolog1.43527158
49MP0002095_abnormal_skin_pigmentation1.43201850
50MP0003315_abnormal_perineum_morphology1.43095839
51MP0001542_abnormal_bone_strength1.42649234
52MP0005164_abnormal_response_to1.40392666
53MP0000343_altered_response_to1.39239669
54MP0001845_abnormal_inflammatory_respons1.38557043
55MP0006035_abnormal_mitochondrial_morpho1.36901529
56MP0008875_abnormal_xenobiotic_pharmacok1.35739589
57MP0004019_abnormal_vitamin_homeostasis1.33332628
58MP0009046_muscle_twitch1.31386955
59MP0005332_abnormal_amino_acid1.28612414
60MP0005365_abnormal_bile_salt1.28204548
61MP0006292_abnormal_olfactory_placode1.24443085
62MP0002163_abnormal_gland_morphology1.23439799
63MP0002090_abnormal_vision1.23274143
64MP0001529_abnormal_vocalization1.21435516
65MP0002006_tumorigenesis1.21157644
66MP0002653_abnormal_ependyma_morphology1.20164549
67MP0003453_abnormal_keratinocyte_physiol1.20006692
68MP0005084_abnormal_gallbladder_morpholo1.19932190
69MP0002736_abnormal_nociception_after1.18869627
70MP0002638_abnormal_pupillary_reflex1.17485072
71MP0005058_abnormal_lysosome_morphology1.17212634
72MP0002098_abnormal_vibrissa_morphology1.16160578
73MP0004742_abnormal_vestibular_system1.15941433
74MP0002102_abnormal_ear_morphology1.15386280
75MP0005464_abnormal_platelet_physiology1.15273993
76MP0003448_altered_tumor_morphology1.13587893
77MP0004947_skin_inflammation1.12989013
78MP0003191_abnormal_cellular_cholesterol1.12235748
79MP0005253_abnormal_eye_physiology1.11500849
80MP0005075_abnormal_melanosome_morpholog1.11098571
81MP0000858_altered_metastatic_potential1.10046816
82MP0001851_eye_inflammation1.09673866
83* MP0005408_hypopigmentation1.06950114
84MP0003880_abnormal_central_pattern1.06303811
85MP0003786_premature_aging1.03197202
86MP0010155_abnormal_intestine_physiology1.02876222
87MP0004883_abnormal_blood_vessel1.01884703
88MP0001984_abnormal_olfaction1.00933159
89MP0005171_absent_coat_pigmentation1.00901402
90MP0000358_abnormal_cell_content/1.00599390
91MP0000371_diluted_coat_color0.98649085
92MP0005174_abnormal_tail_pigmentation0.96209737
93MP0005085_abnormal_gallbladder_physiolo0.95489909
94MP0005501_abnormal_skin_physiology0.95198640
95MP0009763_increased_sensitivity_to0.93733464
96MP0001324_abnormal_eye_pigmentation0.92426122
97MP0001905_abnormal_dopamine_level0.90468735
98MP0005310_abnormal_salivary_gland0.90416107
99MP0001216_abnormal_epidermal_layer0.88386253
100MP0000920_abnormal_myelination0.88345018
101MP0000716_abnormal_immune_system0.87675354
102* MP0002295_abnormal_pulmonary_circulatio0.86391424
103MP0005165_increased_susceptibility_to0.86008811
104MP0005083_abnormal_biliary_tract0.85872895
105MP0009745_abnormal_behavioral_response0.84186435
106MP0005390_skeleton_phenotype0.82194183
107MP0008058_abnormal_DNA_repair0.81702271
108MP0002136_abnormal_kidney_physiology0.81359229
109MP0009643_abnormal_urine_homeostasis0.80762814
110MP0002998_abnormal_bone_remodeling0.80753558
111MP0003075_altered_response_to0.79897604
112MP0002876_abnormal_thyroid_physiology0.79894735
113MP0002282_abnormal_trachea_morphology0.79656854
114MP0001764_abnormal_homeostasis0.79649003
115MP0002139_abnormal_hepatobiliary_system0.79243589
116MP0005551_abnormal_eye_electrophysiolog0.78544115
117MP0004510_myositis0.78199698
118MP0003123_paternal_imprinting0.78193337
119MP0008789_abnormal_olfactory_epithelium0.77164382
120MP0005410_abnormal_fertilization0.76516186
121MP0008260_abnormal_autophagy0.76256076
122MP0001879_abnormal_lymphatic_vessel0.76133487
123MP0001756_abnormal_urination0.76018246
124MP0002272_abnormal_nervous_system0.75596024
125MP0005360_urolithiasis0.74980080
126MP0002166_altered_tumor_susceptibility0.74612025
127MP0003303_peritoneal_inflammation0.74167656
128MP0005379_endocrine/exocrine_gland_phen0.73254317
129MP0003638_abnormal_response/metabolism_0.72710642
130MP0005195_abnormal_posterior_eye0.72029747
131MP0010386_abnormal_urinary_bladder0.70685112
132MP0004133_heterotaxia0.70513716
133MP0009697_abnormal_copulation0.69821297
134MP0000249_abnormal_blood_vessel0.69724982
135MP0000647_abnormal_sebaceous_gland0.69355629
136MP0000026_abnormal_inner_ear0.69283050
137MP0008995_early_reproductive_senescence0.68913041
138MP0005167_abnormal_blood-brain_barrier0.68600814
139MP0002429_abnormal_blood_cell0.68568046
140MP0005409_darkened_coat_color0.68258789
141MP0003690_abnormal_glial_cell0.68038180
142MP0001919_abnormal_reproductive_system0.67924689
143MP0005275_abnormal_skin_tensile0.67796634
144MP0005376_homeostasis/metabolism_phenot0.67554772
145MP0006276_abnormal_autonomic_nervous0.66992192
146* MP0002064_seizures0.66402330
147MP0001485_abnormal_pinna_reflex0.63227754
148* MP0003718_maternal_effect0.62135901
149MP0005367_renal/urinary_system_phenotyp0.61651443
150MP0000516_abnormal_urinary_system0.61651443
151MP0005266_abnormal_metabolism0.60851457
152MP0001968_abnormal_touch/_nociception0.60383837
153MP0005646_abnormal_pituitary_gland0.60186818
154MP0005319_abnormal_enzyme/_coenzyme0.60106220
155MP0002693_abnormal_pancreas_physiology0.58981237
156MP0001727_abnormal_embryo_implantation0.58211141
157MP0001663_abnormal_digestive_system0.58075353
158MP0003938_abnormal_ear_development0.57838036

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.35595867
2Parakeratosis (HP:0001036)4.28626680
3Abnormality of cells of the erythroid lineage (HP:0012130)4.12721046
4Eczematoid dermatitis (HP:0000976)4.09045797
5Recurrent bacterial skin infections (HP:0005406)4.08512619
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.98616212
7Renal Fanconi syndrome (HP:0001994)3.70721696
8Increased hepatocellular lipid droplets (HP:0006565)3.65010665
9Reticulocytopenia (HP:0001896)3.58737396
10Exertional dyspnea (HP:0002875)3.56117165
11Abnormality of macrophages (HP:0004311)3.52887648
12Recurrent gram-negative bacterial infections (HP:0005420)3.52670039
13Abnormal number of erythroid precursors (HP:0012131)3.50337225
14Vacuolated lymphocytes (HP:0001922)3.49704564
15Acute necrotizing encephalopathy (HP:0006965)3.40893007
16Congenital ichthyosiform erythroderma (HP:0007431)3.38373393
17Lactic acidosis (HP:0003128)3.34837720
18Mitochondrial inheritance (HP:0001427)3.29174736
19Lipid accumulation in hepatocytes (HP:0006561)3.26096858
20Abnormal hemoglobin (HP:0011902)3.22859625
21Generalized aminoaciduria (HP:0002909)3.19742307
22Optic disc pallor (HP:0000543)3.10655502
23Systemic lupus erythematosus (HP:0002725)3.09426952
24Macrocytic anemia (HP:0001972)3.07550065
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98201180
26Axonal loss (HP:0003447)2.95331490
27Elevated erythrocyte sedimentation rate (HP:0003565)2.93314869
28Acute encephalopathy (HP:0006846)2.84984816
29Abnormal mitochondria in muscle tissue (HP:0008316)2.83376805
303-Methylglutaconic aciduria (HP:0003535)2.74995028
31Mediastinal lymphadenopathy (HP:0100721)2.72911959
32Increased IgM level (HP:0003496)2.72683827
33Lethargy (HP:0001254)2.71351706
34Progressive macrocephaly (HP:0004481)2.68339059
35Abnormality of renal resorption (HP:0011038)2.67284788
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.67211862
37Abnormality of liposaccharide metabolism (HP:0010968)2.67002447
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.67002447
39Abnormality of glycolipid metabolism (HP:0010969)2.67002447
40Stenosis of the external auditory canal (HP:0000402)2.59922145
41Increased CSF lactate (HP:0002490)2.59826984
42Methylmalonic aciduria (HP:0012120)2.56979946
43Recurrent skin infections (HP:0001581)2.56924291
44Pallor (HP:0000980)2.56407380
45Abnormality of the axillary hair (HP:0100134)2.53619081
46Abnormality of secondary sexual hair (HP:0009888)2.53619081
47Hepatosplenomegaly (HP:0001433)2.51532395
48CNS demyelination (HP:0007305)2.49888625
49Prolonged neonatal jaundice (HP:0006579)2.47863174
50Hepatocellular necrosis (HP:0001404)2.47163735
51Type I transferrin isoform profile (HP:0003642)2.46524762
52Increased intramyocellular lipid droplets (HP:0012240)2.46449491
53Hepatic necrosis (HP:0002605)2.43825225
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40431095
55Obstructive lung disease (HP:0006536)2.39958852
56Chronic obstructive pulmonary disease (HP:0006510)2.39958852
57Methylmalonic acidemia (HP:0002912)2.36341659
58Degeneration of anterior horn cells (HP:0002398)2.35998490
59Abnormality of the anterior horn cell (HP:0006802)2.35998490
60X-linked dominant inheritance (HP:0001423)2.31083568
61Glycosuria (HP:0003076)2.28166230
62Abnormality of urine glucose concentration (HP:0011016)2.28166230
63Cerebral edema (HP:0002181)2.25907226
64Limb dystonia (HP:0002451)2.25855708
65Oral leukoplakia (HP:0002745)2.24778364
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24229440
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24229440
68Emotional lability (HP:0000712)2.22684003
69Congenital, generalized hypertrichosis (HP:0004540)2.20315345
70Stomatitis (HP:0010280)2.20261549
71Erythroderma (HP:0001019)2.19058871
72Poor head control (HP:0002421)2.18489329
73Abnormality of midbrain morphology (HP:0002418)2.13987565
74Molar tooth sign on MRI (HP:0002419)2.13987565
75Increased muscle lipid content (HP:0009058)2.10945614
76Pancreatic cysts (HP:0001737)2.10213648
77Respiratory difficulties (HP:0002880)2.10085816
78Nausea (HP:0002018)2.09923051
79Petechiae (HP:0000967)2.09049533
80Abnormality of methionine metabolism (HP:0010901)2.08381892
81Prolonged partial thromboplastin time (HP:0003645)2.07770080
82Thick nail (HP:0001805)2.07613791
83Amniotic constriction ring (HP:0009775)2.03267625
84Abnormality of placental membranes (HP:0011409)2.03267625
85Vasculitis (HP:0002633)2.01811534
86Purpura (HP:0000979)2.01156083
87Urticaria (HP:0001025)2.00993293
88Gingivitis (HP:0000230)2.00827509
89Blindness (HP:0000618)2.00410107
90Hyperphosphaturia (HP:0003109)1.99759688
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98903157
92Dicarboxylic aciduria (HP:0003215)1.98903157
93Renal tubular dysfunction (HP:0000124)1.98828599
94Pancreatic fibrosis (HP:0100732)1.98811421
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94808056
96Respiratory failure (HP:0002878)1.94781530
97Abnormal pupillary function (HP:0007686)1.94453199
98Orchitis (HP:0100796)1.93716293
99Paralysis (HP:0003470)1.90397733
100Abnormal protein glycosylation (HP:0012346)1.89030237
101Abnormal glycosylation (HP:0012345)1.89030237
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89030237
103Abnormal protein N-linked glycosylation (HP:0012347)1.89030237
104Basal ganglia calcification (HP:0002135)1.88822096
105Glomerulonephritis (HP:0000099)1.88664792
106Aplastic anemia (HP:0001915)1.87021517
107Vomiting (HP:0002013)1.84342270
108Polyphagia (HP:0002591)1.83532423
109Recurrent pneumonia (HP:0006532)1.83396559
110Exercise intolerance (HP:0003546)1.82168676
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.81454129
112Concave nail (HP:0001598)1.81419074
113True hermaphroditism (HP:0010459)1.81352855
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81253731
115Sparse eyelashes (HP:0000653)1.79966066
116Myositis (HP:0100614)1.79896927
117Reduced antithrombin III activity (HP:0001976)1.78377272
118Amyloidosis (HP:0011034)1.78013501
119Optic neuritis (HP:0100653)1.77611469
120Retrobulbar optic neuritis (HP:0100654)1.77611469
121Steatorrhea (HP:0002570)1.77608281
122Hypokinesia (HP:0002375)1.77256809
123Joint hemorrhage (HP:0005261)1.77200805
124Hypergammaglobulinemia (HP:0010702)1.76729954
125Opisthotonus (HP:0002179)1.75919292
126Prostate neoplasm (HP:0100787)1.74715248
127Conical tooth (HP:0000698)1.74566830
128Myokymia (HP:0002411)1.74378622
129Pruritus (HP:0000989)1.73341705
130Leukodystrophy (HP:0002415)1.72622138
131Abnormal urine phosphate concentration (HP:0012599)1.72512742
132Increased serum pyruvate (HP:0003542)1.71391839
133Nephronophthisis (HP:0000090)1.70511469
134Hypothermia (HP:0002045)1.70393795
135Gliosis (HP:0002171)1.70224334
136Pustule (HP:0200039)1.68849608
137Anhidrosis (HP:0000970)1.68131509
138Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67842454
139Increased serum lactate (HP:0002151)1.67661154
140Segmental peripheral demyelination/remyelination (HP:0003481)1.67346257
141Patchy hypopigmentation of hair (HP:0011365)1.66971026
142Tetraparesis (HP:0002273)1.66891123
143Gangrene (HP:0100758)1.66678261
144Medial flaring of the eyebrow (HP:0010747)1.65328074
145Sclerocornea (HP:0000647)1.57367075
146Rough bone trabeculation (HP:0100670)1.56099120
147Delayed CNS myelination (HP:0002188)1.55222450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.34503607
2PBK4.84782816
3NME23.85656171
4MST43.49543086
5PIM23.46209448
6MAP3K143.10304467
7BLK2.82727838
8IRAK42.37505838
9IRAK32.34370433
10IKBKB2.19331569
11TBK12.16895913
12TAF11.97407565
13BMPR21.92482920
14KDR1.85834828
15RIPK41.85069918
16ABL21.84825025
17ARAF1.81678868
18TYK21.78839973
19TESK11.63808598
20IKBKE1.63046031
21MAP3K31.57057391
22BMPR1B1.53825261
23WNK31.51416875
24STK391.47905647
25MST1R1.40631198
26LIMK11.38491151
27BCR1.35121300
28TESK21.33824535
29MAP3K121.31126567
30VRK11.25780260
31TLK11.25241928
32GRK71.21622651
33MAP3K111.20763194
34STK161.20735730
35NEK11.19418558
36GRK11.15534486
37EPHA21.11341441
38ADRBK21.11309493
39MAP2K71.10796372
40MYLK1.07829571
41MAP4K21.04134215
42PDK21.03392812
43MAP2K21.01964756
44CSNK1G31.01219087
45PIM10.98541914
46TRIM280.95866944
47EPHB10.92014253
48ZAK0.91477369
49EIF2AK30.90991240
50LRRK20.90848915
51TIE10.89780116
52TXK0.89627619
53EIF2AK20.89554201
54BUB10.89312076
55TRPM70.88518379
56IRAK20.87789334
57NME10.87143623
58CSNK1G20.86262214
59TEC0.85930349
60CDK190.85901128
61IRAK10.85519935
62JAK30.84132922
63PLK30.82369040
64CDK80.81417122
65OXSR10.80919232
66DYRK20.80607790
67DYRK30.79699490
68EIF2AK10.79473482
69CHUK0.78881138
70PHKG20.78515247
71PHKG10.78515247
72NEK90.77826734
73EPHB20.77501823
74GRK50.76535257
75CSNK1G10.73876345
76MET0.72358509
77SRPK10.72219273
78LYN0.72046787
79FGR0.71740072
80KIT0.70614734
81CDC70.69490714
82TGFBR10.69273006
83AURKA0.68734696
84RPS6KA50.67953993
85RPS6KA40.66926620
86DAPK10.66553720
87DAPK30.65884677
88SYK0.65824061
89MAPK150.65717085
90YES10.65152975
91NLK0.65101321
92CCNB10.64472712
93PRKCD0.63816721
94CASK0.63096068
95STK40.62827362
96MARK30.62676790
97MAPKAPK50.62138719
98PRKCG0.61960840
99TAOK30.60801314
100PLK40.60635044
101INSRR0.60072130
102PAK40.58811133
103CSNK2A20.58790242
104PKN10.58754405
105WNK40.58051123
106MATK0.56961462
107PIK3CG0.56793852
108PRKCI0.56706865
109BTK0.56468455
110CSNK1A1L0.55396988
111DDR20.55280610
112TNIK0.55168855
113ADRBK10.54415596
114MAP2K30.53745967
115MAPKAPK20.53518390
116MAP4K10.52765544
117NUAK10.52712119
118ACVR1B0.52110554
119ILK0.51190493
120CSK0.51185881
121ERBB30.50016088
122MAP3K40.49362931
123MUSK0.49257786
124PAK30.48805101
125BRAF0.48782361
126RPS6KB20.47810340
127ERN10.47363230
128CLK10.46600009
129TGFBR20.46376047
130LCK0.46154081
131PRKCE0.44734277
132PNCK0.44437181
133ERBB40.44066565
134WEE10.44051155
135TAOK20.43334705
136MAP2K60.43257942
137AURKB0.43005022
138PAK10.42665440
139PINK10.41966877
140ABL10.41892101
141MAP3K50.41715098
142PLK10.41546497
143CSNK2A10.41417537
144PRKG20.40887936
145CAMK2G0.40812711
146ZAP700.40137523
147MAPKAPK30.40049570
148PRKCQ0.39484034
149CDK140.38814479
150CAMK2D0.38567047
151NEK60.38550513
152PLK20.38448601
153MOS0.38346531
154BCKDK0.38203842
155CDK11A0.36638248
156TAOK10.36012584
157CDK180.35647402
158CDK150.35092308

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.61979465
2Oxidative phosphorylation_Homo sapiens_hsa001903.60099098
3Proteasome_Homo sapiens_hsa030503.52936727
4Parkinsons disease_Homo sapiens_hsa050122.72197323
5Graft-versus-host disease_Homo sapiens_hsa053322.56816652
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51131317
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.21013732
8Allograft rejection_Homo sapiens_hsa053302.02770841
9Protein export_Homo sapiens_hsa030602.02731331
10Alzheimers disease_Homo sapiens_hsa050101.97944810
11Rheumatoid arthritis_Homo sapiens_hsa053231.94873442
12Huntingtons disease_Homo sapiens_hsa050161.92449180
13RNA polymerase_Homo sapiens_hsa030201.86714239
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84185639
15Steroid biosynthesis_Homo sapiens_hsa001001.73360154
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72577774
17Staphylococcus aureus infection_Homo sapiens_hsa051501.72353901
18Fatty acid elongation_Homo sapiens_hsa000621.61379384
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58535543
20Glutathione metabolism_Homo sapiens_hsa004801.52773893
21Chemical carcinogenesis_Homo sapiens_hsa052041.52672980
22Asthma_Homo sapiens_hsa053101.46672158
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43602378
24Histidine metabolism_Homo sapiens_hsa003401.43229636
25Leishmaniasis_Homo sapiens_hsa051401.40006657
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39679383
27Pertussis_Homo sapiens_hsa051331.37273578
28Mismatch repair_Homo sapiens_hsa034301.35618567
29Phenylalanine metabolism_Homo sapiens_hsa003601.31167448
30Legionellosis_Homo sapiens_hsa051341.30442709
31Autoimmune thyroid disease_Homo sapiens_hsa053201.30325918
32Collecting duct acid secretion_Homo sapiens_hsa049661.28072133
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21168745
34Arachidonic acid metabolism_Homo sapiens_hsa005901.21139002
35Phagosome_Homo sapiens_hsa041451.20976599
36Malaria_Homo sapiens_hsa051441.20072100
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.19902305
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.19302908
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17706603
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17385905
41Nucleotide excision repair_Homo sapiens_hsa034201.11746152
42DNA replication_Homo sapiens_hsa030301.10497474
43Retinol metabolism_Homo sapiens_hsa008301.10153870
44Tyrosine metabolism_Homo sapiens_hsa003501.09086544
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08669703
46Sulfur metabolism_Homo sapiens_hsa009201.06344194
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05405164
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04479304
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01330155
50Pyrimidine metabolism_Homo sapiens_hsa002401.00320548
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.99665211
52Folate biosynthesis_Homo sapiens_hsa007900.99651541
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96708627
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96675835
55Complement and coagulation cascades_Homo sapiens_hsa046100.95923915
56Peroxisome_Homo sapiens_hsa041460.95807313
57African trypanosomiasis_Homo sapiens_hsa051430.91339993
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90493877
59Basal transcription factors_Homo sapiens_hsa030220.88982344
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88805216
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88752371
62Other glycan degradation_Homo sapiens_hsa005110.88406116
63Salmonella infection_Homo sapiens_hsa051320.85734910
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85644285
65Lysosome_Homo sapiens_hsa041420.85255247
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.82439818
67Purine metabolism_Homo sapiens_hsa002300.82024681
68Spliceosome_Homo sapiens_hsa030400.80554008
69Tuberculosis_Homo sapiens_hsa051520.80471030
70Type I diabetes mellitus_Homo sapiens_hsa049400.79856164
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77241374
72Base excision repair_Homo sapiens_hsa034100.76493135
73Linoleic acid metabolism_Homo sapiens_hsa005910.74927624
74Caffeine metabolism_Homo sapiens_hsa002320.73662458
75Arginine and proline metabolism_Homo sapiens_hsa003300.73470750
76Butanoate metabolism_Homo sapiens_hsa006500.73417215
77Ether lipid metabolism_Homo sapiens_hsa005650.73223789
78Hematopoietic cell lineage_Homo sapiens_hsa046400.72156870
79Sphingolipid metabolism_Homo sapiens_hsa006000.71756809
80Vibrio cholerae infection_Homo sapiens_hsa051100.68987817
81RNA degradation_Homo sapiens_hsa030180.67524128
82beta-Alanine metabolism_Homo sapiens_hsa004100.66403566
83TNF signaling pathway_Homo sapiens_hsa046680.66223357
84Measles_Homo sapiens_hsa051620.65023223
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64716321
86Sulfur relay system_Homo sapiens_hsa041220.62736150
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.62542417
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59326829
89* Mineral absorption_Homo sapiens_hsa049780.59055143
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57978851
91Apoptosis_Homo sapiens_hsa042100.57847165
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57212895
93Metabolic pathways_Homo sapiens_hsa011000.55169541
94Influenza A_Homo sapiens_hsa051640.53416927
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.52839257
96Synaptic vesicle cycle_Homo sapiens_hsa047210.52591909
97Pyruvate metabolism_Homo sapiens_hsa006200.51660728
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.51119847
99Fanconi anemia pathway_Homo sapiens_hsa034600.50852785
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50040145
101Herpes simplex infection_Homo sapiens_hsa051680.49974025
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49970237
103Osteoclast differentiation_Homo sapiens_hsa043800.49700164
104Shigellosis_Homo sapiens_hsa051310.48594711
105Vitamin digestion and absorption_Homo sapiens_hsa049770.48117173
106Propanoate metabolism_Homo sapiens_hsa006400.48063988
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47319307
108Cardiac muscle contraction_Homo sapiens_hsa042600.45187769
109Fructose and mannose metabolism_Homo sapiens_hsa000510.43606781
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41330344
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41077367
112Epstein-Barr virus infection_Homo sapiens_hsa051690.40822585
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39888470
114N-Glycan biosynthesis_Homo sapiens_hsa005100.39556611
115Homologous recombination_Homo sapiens_hsa034400.37175825
116Toxoplasmosis_Homo sapiens_hsa051450.37045709
117Regulation of autophagy_Homo sapiens_hsa041400.37027912
118Chemokine signaling pathway_Homo sapiens_hsa040620.35902316
119Tryptophan metabolism_Homo sapiens_hsa003800.35579779
120Hepatitis C_Homo sapiens_hsa051600.34222909
121Prion diseases_Homo sapiens_hsa050200.33398049
122Pentose phosphate pathway_Homo sapiens_hsa000300.33267840
123Antigen processing and presentation_Homo sapiens_hsa046120.33212920
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32223048
125Phototransduction_Homo sapiens_hsa047440.31543358
126Selenocompound metabolism_Homo sapiens_hsa004500.31326526
127RNA transport_Homo sapiens_hsa030130.31119448
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30967411
129Galactose metabolism_Homo sapiens_hsa000520.30078518
130Systemic lupus erythematosus_Homo sapiens_hsa053220.28962641
131One carbon pool by folate_Homo sapiens_hsa006700.28055550
132Fatty acid degradation_Homo sapiens_hsa000710.27213609
133Carbon metabolism_Homo sapiens_hsa012000.25255189
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21664373
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20333085

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