ATP10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome, also known as 'happy puppet syndrome'. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.99004380
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.99004380
3positive regulation of gamma-delta T cell activation (GO:0046645)4.94565329
4antigen processing and presentation of endogenous antigen (GO:0019883)4.16290740
5regulation of gamma-delta T cell differentiation (GO:0045586)4.08316590
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.97648881
7regulation of gamma-delta T cell activation (GO:0046643)3.79986043
8negative T cell selection (GO:0043383)3.76900273
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.76441014
10positive regulation of natural killer cell differentiation (GO:0032825)3.69988428
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68385070
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58919659
13tyrosine phosphorylation of STAT protein (GO:0007260)3.58396137
14response to interleukin-15 (GO:0070672)3.51544724
15interferon-gamma production (GO:0032609)3.50865396
16negative thymic T cell selection (GO:0045060)3.50468459
17nuclear pore complex assembly (GO:0051292)3.49208678
18positive regulation of isotype switching (GO:0045830)3.36198289
19regulation of T-helper 1 cell differentiation (GO:0045625)3.17859678
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15607970
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.15607970
22modulation by symbiont of host immune response (GO:0052553)3.15607970
23positive regulation by symbiont of host defense response (GO:0052509)3.15607970
24modulation by symbiont of host defense response (GO:0052031)3.15607970
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15607970
26tolerance induction (GO:0002507)3.14642214
27natural killer cell differentiation (GO:0001779)3.14069777
28myeloid dendritic cell differentiation (GO:0043011)3.13414136
29myeloid dendritic cell activation (GO:0001773)3.07999946
30T cell selection (GO:0045058)3.06663364
31regulation of T cell tolerance induction (GO:0002664)3.06501400
32thymic T cell selection (GO:0045061)3.00867379
33stress fiber assembly (GO:0043149)3.00797075
34positive regulation of immunoglobulin mediated immune response (GO:0002891)2.96867494
35positive regulation of B cell mediated immunity (GO:0002714)2.96867494
36nuclear pore organization (GO:0006999)2.96246409
37negative regulation of cell killing (GO:0031342)2.96103151
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96103151
39negative regulation of T cell mediated immunity (GO:0002710)2.93716453
40macrophage activation involved in immune response (GO:0002281)2.93497199
41positive thymic T cell selection (GO:0045059)2.92851248
42regulation of interleukin-2 biosynthetic process (GO:0045076)2.90801055
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90555824
44regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89146426
45leukocyte aggregation (GO:0070486)2.86078612
46adhesion of symbiont to host cell (GO:0044650)2.85649021
47virion attachment to host cell (GO:0019062)2.85649021
48response to peptidoglycan (GO:0032494)2.85363168
49JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84358886
50antigen processing and presentation via MHC class Ib (GO:0002475)2.84122608
51regulation of vitamin D biosynthetic process (GO:0060556)2.83990770
52positive regulation of tolerance induction (GO:0002645)2.81956129
53regulation of T-helper 2 cell differentiation (GO:0045628)2.80805818
54T cell migration (GO:0072678)2.80054580
55cellular response to interleukin-15 (GO:0071350)2.78914787
56regulation of tolerance induction (GO:0002643)2.77702007
57regulation of type 2 immune response (GO:0002828)2.76034578
58positive regulation of interleukin-2 production (GO:0032743)2.75305520
59response to interferon-alpha (GO:0035455)2.72989847
60natural killer cell activation (GO:0030101)2.72942181
61collagen fibril organization (GO:0030199)2.72870259
62response to laminar fluid shear stress (GO:0034616)2.72497488
63fibril organization (GO:0097435)2.72129934
64negative regulation of type 2 immune response (GO:0002829)2.72117675
65pore complex assembly (GO:0046931)2.71426005
66response to type I interferon (GO:0034340)2.70589482
67positive T cell selection (GO:0043368)2.70575037
68protein heterotrimerization (GO:0070208)2.70564273
69definitive hemopoiesis (GO:0060216)2.69612414
70positive regulation of DNA recombination (GO:0045911)2.69027017
71mitotic sister chromatid cohesion (GO:0007064)2.68684725
72regulation of interferon-beta biosynthetic process (GO:0045357)2.68653803
73negative regulation of nitric oxide biosynthetic process (GO:0045019)2.68584943
74detection of molecule of bacterial origin (GO:0032490)2.68499984
75protein localization to endosome (GO:0036010)2.67629258
76response to muramyl dipeptide (GO:0032495)2.67051416
77negative regulation of cytokine production involved in immune response (GO:0002719)2.66371509
78skin morphogenesis (GO:0043589)2.66261329
79cellular response to type I interferon (GO:0071357)2.65929668
80type I interferon signaling pathway (GO:0060337)2.65929668
81T cell costimulation (GO:0031295)2.64720501
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.64664773
83regulation of extracellular matrix disassembly (GO:0010715)2.64604547
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.64559975
85T cell homeostasis (GO:0043029)2.63876088
86cellular response to interferon-alpha (GO:0035457)2.62414544
87regulation of natural killer cell differentiation (GO:0032823)2.61413954
88regulation of B cell receptor signaling pathway (GO:0050855)2.57970648
89lymphocyte costimulation (GO:0031294)2.57842332
90positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57277090
91regulation of isotype switching to IgG isotypes (GO:0048302)2.57194545
92endothelial tube morphogenesis (GO:0061154)2.56654279
93morphogenesis of an endothelium (GO:0003159)2.56654279
94regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56580589
95regulation of T cell mediated cytotoxicity (GO:0001914)2.56431722
96alpha-beta T cell activation (GO:0046631)2.56312082
97regulation of interferon-alpha production (GO:0032647)2.56198796
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.55035611
99regulation of natural killer cell mediated immunity (GO:0002715)2.55035611
100barbed-end actin filament capping (GO:0051016)2.53773094
101regulation of alpha-beta T cell proliferation (GO:0046640)2.52568681
102positive regulation of natural killer cell mediated immunity (GO:0002717)2.52411598
103positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.52411598
104positive regulation of type 2 immune response (GO:0002830)2.51761312
105positive regulation of B cell differentiation (GO:0045579)2.51721728
106T cell receptor signaling pathway (GO:0050852)2.50039906
107regulation of regulatory T cell differentiation (GO:0045589)2.49986866
108positive regulation of histone deacetylation (GO:0031065)2.47545982
109positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46435655
110lymphocyte chemotaxis (GO:0048247)2.46414503
111NIK/NF-kappaB signaling (GO:0038061)2.46115555
112negative regulation of interleukin-12 production (GO:0032695)2.46040967
113positive regulation of macrophage differentiation (GO:0045651)2.45768192
114negative regulation of erythrocyte differentiation (GO:0045647)2.44347767
115pinocytosis (GO:0006907)2.44249786
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.44129363
117negative regulation of leukocyte mediated immunity (GO:0002704)2.43633699
118positive regulation of interferon-alpha production (GO:0032727)2.43054704
119positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.42876163
120T cell apoptotic process (GO:0070231)2.42713721
121activated T cell proliferation (GO:0050798)2.42354533
122adhesion of symbiont to host (GO:0044406)2.42220298
123regulation of B cell differentiation (GO:0045577)2.41676404
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41660369
125mast cell activation (GO:0045576)2.41296023
126T cell proliferation (GO:0042098)2.41106571
127germ cell migration (GO:0008354)2.40232438
128alpha-beta T cell differentiation (GO:0046632)2.40205137
129detection of other organism (GO:0098543)2.39994753
130cell migration involved in heart development (GO:0060973)2.39938099
131leukocyte cell-cell adhesion (GO:0007159)2.39677959
132positive regulation of alpha-beta T cell proliferation (GO:0046641)2.39280525
133response to protozoan (GO:0001562)2.38210255
134germinal center formation (GO:0002467)2.38144332
135regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.36975300
136regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.36871101
137positive regulation of humoral immune response (GO:0002922)2.36859641
138DNA unwinding involved in DNA replication (GO:0006268)2.36646957
139positive regulation of interleukin-17 production (GO:0032740)2.36465717
140negative regulation of viral genome replication (GO:0045071)2.35866939
141substrate-dependent cell migration (GO:0006929)2.35810381
142extracellular matrix assembly (GO:0085029)2.35190222
143negative regulation of interleukin-6 production (GO:0032715)2.34834960
144cellular extravasation (GO:0045123)2.34499745
145detection of external biotic stimulus (GO:0098581)2.34445652
146regulation of leukocyte mediated cytotoxicity (GO:0001910)2.34303767
147regulation of interleukin-2 production (GO:0032663)2.34268042
148regulation of podosome assembly (GO:0071801)2.34063950
149cellular response to virus (GO:0098586)2.34032232
150interferon-gamma-mediated signaling pathway (GO:0060333)2.33912394
151defense response to protozoan (GO:0042832)2.33721335
152positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.33616251
153embryonic process involved in female pregnancy (GO:0060136)2.33139301
154positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.33134345
155positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.32715640
156regulation of isotype switching (GO:0045191)2.32635124
157lymphocyte homeostasis (GO:0002260)2.32561200
158T cell differentiation (GO:0030217)2.31481745
159regulation of response to interferon-gamma (GO:0060330)2.31041165
160lymph node development (GO:0048535)2.30831741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60105275
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.76980001
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.50227658
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.23502843
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.78261093
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43131048
7MYC_22102868_ChIP-Seq_BL_Human3.16749164
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14153557
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11574601
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.81679169
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79962633
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71212207
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.71068227
14* MYB_26560356_Chip-Seq_TH2_Human2.66123795
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.64298499
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61356055
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57721071
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.55435616
19RUNX_20019798_ChIP-Seq_JUKART_Human2.53611960
20SCL_19346495_ChIP-Seq_HPC-7_Human2.45448360
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.34904144
22* MYB_26560356_Chip-Seq_TH1_Human2.34324418
23MAF_26560356_Chip-Seq_TH1_Human2.31155765
24VDR_21846776_ChIP-Seq_THP-1_Human2.23957067
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22987466
26TCF7_22412390_ChIP-Seq_EML_Mouse2.21433568
27IRF8_27001747_Chip-Seq_BMDM_Mouse2.16282040
28UTX_26944678_Chip-Seq_JUKART_Human2.09431210
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07184885
30TRIM28_21343339_ChIP-Seq_HEK293_Human2.04703095
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04678788
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03838545
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00208972
34* VDR_24763502_ChIP-Seq_THP-1_Human1.94341682
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89104946
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.87549098
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85859812
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85198548
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78395325
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76991196
41* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74403778
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73641660
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72997732
44SPI1_23547873_ChIP-Seq_NB4_Human1.68609112
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.66035128
46KDM2B_26808549_Chip-Seq_DND41_Human1.62330647
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.59548408
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56744761
49GATA3_27048872_Chip-Seq_THYMUS_Human1.55904758
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.53291560
51* LXR_22292898_ChIP-Seq_THP-1_Human1.51835650
52* MAF_26560356_Chip-Seq_TH2_Human1.47228109
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41107894
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38814992
55SPI1_23127762_ChIP-Seq_K562_Human1.35873008
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35050895
57PU_27001747_Chip-Seq_BMDM_Mouse1.29203356
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27658957
59SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25483092
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23202244
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22987004
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.22235038
63BRD4_25478319_ChIP-Seq_HGPS_Human1.21780629
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19627161
65* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18036238
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17467488
67KDM2B_26808549_Chip-Seq_K562_Human1.17102460
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16995765
69* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15114667
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14806814
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.13840667
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11732733
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10838720
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10582849
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10145936
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09202975
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09041246
78GATA1_19941826_ChIP-Seq_K562_Human1.08789754
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08780179
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07278783
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06782100
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05297842
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03182768
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03169554
85* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03149261
86CJUN_26792858_Chip-Seq_BT549_Human1.02116601
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.02112938
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02045441
89NCOR1_26117541_ChIP-Seq_K562_Human1.01555166
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.00677159
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.00677159
92* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00491674
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99769442
94RACK7_27058665_Chip-Seq_MCF-7_Human0.98303485
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98265214
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98265214
97* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97175536
98GATA3_26560356_Chip-Seq_TH2_Human0.97173396
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96379052
100* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95700940
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94909405
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94310182
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94001045
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92882294
105AR_21909140_ChIP-Seq_LNCAP_Human0.91660187
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90613884
107* VDR_24787735_ChIP-Seq_THP-1_Human0.90593808
108* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90394374
109* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90168412
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89582333
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89228097
112MYC_18555785_ChIP-Seq_MESCs_Mouse0.88297321
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87190208
114TP53_22127205_ChIP-Seq_IMR90_Human0.86936153
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86731441
116GATA2_21666600_ChIP-Seq_HMVEC_Human0.86551176
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86245447
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85939529
119CLOCK_20551151_ChIP-Seq_293T_Human0.85139968
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84574962
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.83258935
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82755759
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82207792
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.81911828
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.81221754
126* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78174411
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78041576
128* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77596437
129ATF3_27146783_Chip-Seq_COLON_Human0.76690944
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76372678
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.74784372
132ELK1_19687146_ChIP-ChIP_HELA_Human0.73835128
133MYC_19079543_ChIP-ChIP_MESCs_Mouse0.73389247
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.72234242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.00387822
2MP0001835_abnormal_antigen_presentation2.87543691
3MP0000685_abnormal_immune_system2.81706389
4MP0005671_abnormal_response_to2.76162559
5MP0003763_abnormal_thymus_physiology2.64311324
6MP0003436_decreased_susceptibility_to2.63106874
7MP0009278_abnormal_bone_marrow2.46045160
8MP0002396_abnormal_hematopoietic_system2.44385013
9MP0001790_abnormal_immune_system2.40510480
10MP0005387_immune_system_phenotype2.40510480
11MP0009785_altered_susceptibility_to2.38334944
12MP0002166_altered_tumor_susceptibility2.38289070
13MP0004808_abnormal_hematopoietic_stem2.36152956
14MP0001800_abnormal_humoral_immune2.25725170
15MP0005257_abnormal_intraocular_pressure2.25519311
16MP0005275_abnormal_skin_tensile2.24773991
17MP0005000_abnormal_immune_tolerance2.23829027
18MP0001545_abnormal_hematopoietic_system2.12781674
19MP0005397_hematopoietic_system_phenotyp2.12781674
20MP0002452_abnormal_antigen_presenting2.12734131
21MP0003303_peritoneal_inflammation2.12451507
22MP0005503_abnormal_tendon_morphology2.12054044
23MP0002405_respiratory_system_inflammati2.11882621
24MP0002006_tumorigenesis2.11411265
25MP0002723_abnormal_immune_serum2.08204023
26MP0002420_abnormal_adaptive_immunity2.05578677
27MP0002398_abnormal_bone_marrow2.05210418
28MP0001542_abnormal_bone_strength2.05163183
29MP0001819_abnormal_immune_cell2.04421417
30MP0010352_gastrointestinal_tract_polyps2.03093364
31MP0005171_absent_coat_pigmentation1.97212817
32MP0005025_abnormal_response_to1.94101440
33MP0003724_increased_susceptibility_to1.93119077
34MP0002933_joint_inflammation1.90624185
35MP0004947_skin_inflammation1.89449652
36MP0009333_abnormal_splenocyte_physiolog1.86836946
37MP0001873_stomach_inflammation1.85529955
38MP0005076_abnormal_cell_differentiation1.83459821
39MP0010155_abnormal_intestine_physiology1.82607128
40MP0002148_abnormal_hypersensitivity_rea1.81027123
41MP0002419_abnormal_innate_immunity1.78715563
42MP0000703_abnormal_thymus_morphology1.77264565
43MP0000716_abnormal_immune_system1.73636760
44MP0003448_altered_tumor_morphology1.73494303
45MP0002722_abnormal_immune_system1.69268100
46MP0004510_myositis1.66500917
47MP0000689_abnormal_spleen_morphology1.65827519
48MP0005058_abnormal_lysosome_morphology1.59715460
49MP0000465_gastrointestinal_hemorrhage1.52975283
50MP0003172_abnormal_lysosome_physiology1.52778258
51MP0001853_heart_inflammation1.52484030
52MP0003191_abnormal_cellular_cholesterol1.51463529
53MP0009384_cardiac_valve_regurgitation1.51243679
54MP0002877_abnormal_melanocyte_morpholog1.50891174
55MP0005464_abnormal_platelet_physiology1.49778100
56MP0006082_CNS_inflammation1.48733053
57MP0002429_abnormal_blood_cell1.48120796
58MP0003705_abnormal_hypodermis_morpholog1.46126881
59MP0001533_abnormal_skeleton_physiology1.46056158
60MP0003566_abnormal_cell_adhesion1.44077859
61MP0000858_altered_metastatic_potential1.39525515
62MP0005164_abnormal_response_to1.37692322
63MP0010307_abnormal_tumor_latency1.36060148
64MP0001845_abnormal_inflammatory_respons1.35376423
65MP0003091_abnormal_cell_migration1.35247480
66MP0010094_abnormal_chromosome_stability1.32385426
67MP0003279_aneurysm1.31691781
68MP0000490_abnormal_crypts_of1.31622217
69MP0002254_reproductive_system_inflammat1.31515752
70MP0008438_abnormal_cutaneous_collagen1.30495063
71MP0005023_abnormal_wound_healing1.30435273
72MP0004883_abnormal_blood_vessel1.27849124
73MP0003866_abnormal_defecation1.27399458
74MP0002998_abnormal_bone_remodeling1.23598389
75MP0001958_emphysema1.23072944
76MP0009840_abnormal_foam_cell1.21802375
77MP0001348_abnormal_lacrimal_gland1.17151379
78MP0000371_diluted_coat_color1.11504793
79MP0006054_spinal_hemorrhage1.10858128
80MP0004272_abnormal_basement_membrane1.10018112
81MP0008057_abnormal_DNA_replication1.09923165
82MP0008007_abnormal_cellular_replicative1.09706965
83MP0002060_abnormal_skin_morphology1.07454150
84MP0002019_abnormal_tumor_incidence1.04149555
85MP0005174_abnormal_tail_pigmentation1.02141184
86MP0003075_altered_response_to1.01885180
87MP0002295_abnormal_pulmonary_circulatio1.00499624
88MP0003077_abnormal_cell_cycle1.00038693
89MP0005451_abnormal_body_composition0.99394011
90MP0001851_eye_inflammation0.98458690
91MP0001879_abnormal_lymphatic_vessel0.97870185
92MP0008004_abnormal_stomach_pH0.97069059
93MP0008260_abnormal_autophagy0.96471907
94MP0003950_abnormal_plasma_membrane0.95866548
95MP0004381_abnormal_hair_follicle0.95658394
96MP0009764_decreased_sensitivity_to0.91768071
97MP0000733_abnormal_muscle_development0.91446731
98MP0005508_abnormal_skeleton_morphology0.91116944
99MP0005623_abnormal_meninges_morphology0.90620145
100MP0003045_fibrosis0.89464578
101MP0005390_skeleton_phenotype0.88287525
102MP0005410_abnormal_fertilization0.87604615
103MP0005595_abnormal_vascular_smooth0.86059487
104MP0008469_abnormal_protein_level0.83569459
105MP0003795_abnormal_bone_structure0.82583238
106MP0001915_intracranial_hemorrhage0.82494634
107MP0003111_abnormal_nucleus_morphology0.82262955
108MP0002009_preneoplasia0.81145319
109MP0000015_abnormal_ear_pigmentation0.80542351
110MP0005075_abnormal_melanosome_morpholog0.79338570
111MP0000372_irregular_coat_pigmentation0.79323964
112MP0000604_amyloidosis0.78122795
113MP0003943_abnormal_hepatobiliary_system0.77976466
114MP0000569_abnormal_digit_pigmentation0.77887612
115MP0001849_ear_inflammation0.77684062
116MP0000343_altered_response_to0.77336982
117MP0000249_abnormal_blood_vessel0.76504530
118MP0000350_abnormal_cell_proliferation0.75509280
119MP0005165_increased_susceptibility_to0.72944392
120MP0005409_darkened_coat_color0.72740449
121MP0005166_decreased_susceptibility_to0.72591071
122MP0002086_abnormal_extraembryonic_tissu0.72040500
123MP0002132_abnormal_respiratory_system0.71478386
124MP0003693_abnormal_embryo_hatching0.71400632
125MP0003453_abnormal_keratinocyte_physiol0.71058769
126MP0004197_abnormal_fetal_growth/weight/0.70286547
127MP0000767_abnormal_smooth_muscle0.67326415
128MP0004957_abnormal_blastocyst_morpholog0.65850715
129MP0002925_abnormal_cardiovascular_devel0.63864916
130MP0002282_abnormal_trachea_morphology0.63402924
131MP0001243_abnormal_dermal_layer0.63183856
132MP0003828_pulmonary_edema0.62400654
133MP0010368_abnormal_lymphatic_system0.62319067
134MP0002113_abnormal_skeleton_development0.61648986

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.49842961
2T lymphocytopenia (HP:0005403)4.10598929
3Abnormality of T cell number (HP:0011839)4.01645618
4Peritonitis (HP:0002586)3.74662006
5Nasal polyposis (HP:0100582)3.60726805
6Recurrent viral infections (HP:0004429)3.53285018
7Elevated erythrocyte sedimentation rate (HP:0003565)3.49758284
8Recurrent fungal infections (HP:0002841)3.34521488
9Increased density of long bones (HP:0006392)3.33335530
10Abnormality of the nasal mucosa (HP:0000433)3.31425967
11Absent frontal sinuses (HP:0002688)3.30579643
12Genu recurvatum (HP:0002816)3.30539412
13Myositis (HP:0100614)3.25124532
14Recurrent bronchitis (HP:0002837)3.18889672
15Abnormality of T cells (HP:0002843)3.08132790
16Chronic otitis media (HP:0000389)3.05131099
17Vascular tortuosity (HP:0004948)2.99763031
18Eczematoid dermatitis (HP:0000976)2.98354486
19Panhypogammaglobulinemia (HP:0003139)2.83994838
20Soft skin (HP:0000977)2.74219967
21Thrombocytosis (HP:0001894)2.73872248
22Abnormality of the fingertips (HP:0001211)2.70825008
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.66380959
24Persistence of primary teeth (HP:0006335)2.65374422
25Aortic regurgitation (HP:0001659)2.64068794
26Recurrent abscess formation (HP:0002722)2.63588829
27Blue sclerae (HP:0000592)2.59844889
28Stomatitis (HP:0010280)2.59707223
29Joint stiffness (HP:0001387)2.59673348
30Orchitis (HP:0100796)2.58251913
31IgM deficiency (HP:0002850)2.57766480
32B lymphocytopenia (HP:0010976)2.57486252
33Abnormality of B cell number (HP:0010975)2.57486252
34Retrobulbar optic neuritis (HP:0100654)2.55803685
35Optic neuritis (HP:0100653)2.55803685
36Arterial tortuosity (HP:0005116)2.55077108
37Follicular hyperkeratosis (HP:0007502)2.52021283
38Bladder diverticulum (HP:0000015)2.51301763
39Mitral regurgitation (HP:0001653)2.50381512
40Wormian bones (HP:0002645)2.49999282
41Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.49881454
42Vertebral compression fractures (HP:0002953)2.49638552
43Abnormality of macrophages (HP:0004311)2.44012353
44Recurrent cutaneous fungal infections (HP:0011370)2.41553880
45Chronic mucocutaneous candidiasis (HP:0002728)2.41553880
46Abnormal platelet volume (HP:0011876)2.41472152
47Slender build (HP:0001533)2.40439801
48Dysostosis multiplex (HP:0000943)2.37690075
49Epiphyseal dysplasia (HP:0002656)2.37615776
50Spinal cord lesions (HP:0100561)2.36745515
51Syringomyelia (HP:0003396)2.36745515
52Type 1 muscle fiber predominance (HP:0003803)2.32451162
53Fragile skin (HP:0001030)2.31885764
54Acute myeloid leukemia (HP:0004808)2.31869189
55Spontaneous hematomas (HP:0007420)2.31361647
56Ocular albinism (HP:0001107)2.30365789
57Osteolytic defects of the hand bones (HP:0009699)2.29997217
58Osteolytic defects of the phalanges of the hand (HP:0009771)2.29997217
59Gastrointestinal infarctions (HP:0005244)2.28814777
60Broad metatarsal (HP:0001783)2.27989526
61Shallow orbits (HP:0000586)2.27873943
62Atrophic scars (HP:0001075)2.27336095
63Abnormality of liposaccharide metabolism (HP:0010968)2.26785691
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.26785691
65Abnormality of glycolipid metabolism (HP:0010969)2.26785691
66Arterial thrombosis (HP:0004420)2.25688795
67Mediastinal lymphadenopathy (HP:0100721)2.25028111
68Eosinophilia (HP:0001880)2.23769813
69Severe combined immunodeficiency (HP:0004430)2.22137211
70Aneurysm (HP:0002617)2.21729382
71IgA deficiency (HP:0002720)2.21314940
72Thin bony cortex (HP:0002753)2.20294519
73Abnormality of T cell physiology (HP:0011840)2.19958869
74Increased variability in muscle fiber diameter (HP:0003557)2.19728964
75Spinal rigidity (HP:0003306)2.18537937
76Autoimmune thrombocytopenia (HP:0001973)2.17540050
77Increased mean platelet volume (HP:0011877)2.16752108
78Cervical subluxation (HP:0003308)2.15620195
79Entropion (HP:0000621)2.15388249
80Emphysema (HP:0002097)2.14532935
81Cellulitis (HP:0100658)2.14140027
82Biconcave vertebral bodies (HP:0004586)2.13061521
83Interstitial pulmonary disease (HP:0006530)2.12636112
84Gastrointestinal inflammation (HP:0004386)2.12617052
85Cerebral aneurysm (HP:0004944)2.11770068
86Leukocytosis (HP:0001974)2.11204236
87Joint laxity (HP:0001388)2.11179471
88Cutaneous melanoma (HP:0012056)2.09131092
89Inflammation of the large intestine (HP:0002037)2.08193189
90Combined immunodeficiency (HP:0005387)2.07618731
91Thyroiditis (HP:0100646)2.07413720
92Aortic aneurysm (HP:0004942)2.06938795
93Aortic valve stenosis (HP:0001650)2.05978961
94Bronchitis (HP:0012387)2.05296862
95Vasculitis (HP:0002633)2.02573930
96Recurrent bacterial skin infections (HP:0005406)2.02076885
97Bicuspid aortic valve (HP:0001647)2.01232754
98Radial bowing (HP:0002986)2.00038925
99Protrusio acetabuli (HP:0003179)1.97489160
100Neonatal short-limb short stature (HP:0008921)1.97224244
101Petechiae (HP:0000967)1.96965335
102Ovoid vertebral bodies (HP:0003300)1.96935717
103Abnormality of dentin (HP:0010299)1.95246962
104Hypoplasia of the iris (HP:0007676)1.95009745
105Keratoconjunctivitis (HP:0001096)1.94605620
106Urinary glycosaminoglycan excretion (HP:0003541)1.94350312
107Mucopolysacchariduria (HP:0008155)1.94350312
108Abnormality of eosinophils (HP:0001879)1.94211530
109Abnormality of skeletal muscle fiber size (HP:0012084)1.94163969
110Hypergammaglobulinemia (HP:0010702)1.94097272
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93996011
112Abnormality of polysaccharide metabolism (HP:0011012)1.93996011
113Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93996011
114Meningitis (HP:0001287)1.93952275
115IgG deficiency (HP:0004315)1.92882384
116Abnormality of the frontal sinuses (HP:0002687)1.91387424
117Pulmonary infiltrates (HP:0002113)1.91029190
118Increased connective tissue (HP:0009025)1.90561165
119Delayed closure of the anterior fontanelle (HP:0001476)1.88685641
120Dilatation of the ascending aorta (HP:0005111)1.88498737
121Hemoptysis (HP:0002105)1.87869721
122Papilledema (HP:0001085)1.86991147
123Hyperextensible skin (HP:0000974)1.86978968
124Bowel diverticulosis (HP:0005222)1.86279419
125Gingivitis (HP:0000230)1.85820030
126Increased IgM level (HP:0003496)1.85688360
127Spondylolisthesis (HP:0003302)1.85161957
128Dislocated radial head (HP:0003083)1.85123893
129Abnormality of the peritoneum (HP:0002585)1.85026738
130Overgrowth (HP:0001548)1.83179478
131Mitral stenosis (HP:0001718)1.80498317
132Hematochezia (HP:0002573)1.80404819
133Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79387797
134Mitral valve prolapse (HP:0001634)1.79291095
135Granulocytopenia (HP:0001913)1.79072902
136Prolonged bleeding time (HP:0003010)1.78863638
137Keratoconjunctivitis sicca (HP:0001097)1.78374887
138Poikiloderma (HP:0001029)1.76850336
139Aortic dissection (HP:0002647)1.76402843
140Abnormal foot bone ossification (HP:0010675)1.75573687
141Flat acetabular roof (HP:0003180)1.74939723
142Periodontitis (HP:0000704)1.74764449
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.73778233
144Increased IgE level (HP:0003212)1.72637424
145Recurrent skin infections (HP:0001581)1.72595108
146High pitched voice (HP:0001620)1.72585423
147Autoimmune hemolytic anemia (HP:0001890)1.72437024
148Lymphoma (HP:0002665)1.70591654
149Mesomelia (HP:0003027)1.70167064
150Basal cell carcinoma (HP:0002671)1.69542283
151Abnormality of the radial head (HP:0003995)1.68885616
152Limited elbow extension (HP:0001377)1.68503996
153Chronic sinusitis (HP:0011109)1.68058923
154Ankle contracture (HP:0006466)1.67979381
155Ulnar bowing (HP:0003031)1.67698704

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.30157109
2EEF2K3.54225992
3PRPF4B3.37226430
4TXK3.26090776
5JAK33.13826334
6STK102.54927409
7TRIB32.16092778
8ERN12.09335049
9ZAP702.08538074
10TYK22.07893637
11MAP3K142.06836809
12PKN22.05692359
13MAP3K102.00454557
14ITK1.95402567
15CDK121.87337981
16TBK11.85945582
17TTN1.79518928
18TEC1.77508187
19KIT1.73650155
20NME21.71013024
21RIPK41.70438547
22LRRK21.68885491
23GRK71.65719753
24FGFR41.63701824
25NLK1.61477750
26IKBKE1.58055976
27CDC42BPA1.57202356
28JAK11.51915402
29MAP3K131.51564166
30FGFR31.48878819
31MYLK1.44166797
32RPS6KA41.42886161
33BTK1.40611760
34TGFBR21.39418371
35PIM11.35118470
36MOS1.32866840
37HCK1.31954827
38EPHB11.30093862
39TAOK21.29850402
40PIM21.29633542
41PRKD21.27085501
42CSK1.26865154
43CDC71.25709865
44NEK21.24236824
45TGFBR11.23184997
46IKBKB1.21771776
47LCK1.18297732
48CDK61.17821770
49MAP2K31.16503256
50SIK11.15250264
51CDK41.12908316
52TRPM71.09781624
53ALK1.05087635
54STK381.02350859
55TESK21.01481150
56CDK91.00238551
57MARK20.98556760
58MST40.98415664
59CHUK0.97661760
60PIK3CG0.94715684
61SYK0.94698232
62PAK20.94104165
63RIPK10.92221506
64TSSK60.91874480
65MAPK70.91114972
66KDR0.90522989
67PTK60.89343817
68BMX0.89063272
69BLK0.88997537
70CLK10.88957903
71MAP3K30.86133931
72RPS6KB20.85958049
73TAOK30.82234841
74TAOK10.80687435
75GRK60.80405648
76PDGFRB0.80051952
77CAMK1D0.77957341
78NEK90.76788864
79EPHA30.75876420
80CSF1R0.75685457
81HIPK20.75069108
82MAP3K110.74249170
83BMPR20.74083498
84TESK10.73620965
85MAP3K80.73438227
86MAP3K10.73195381
87STK30.68476449
88IRAK40.67718861
89TYRO30.67222639
90PAK40.67055474
91SIK30.66564175
92JAK20.66080520
93MAP3K60.65080542
94ATR0.63990135
95MAPK120.63482504
96PRKCH0.62695390
97MATK0.62500091
98AKT30.59731193
99FLT30.58939859
100PASK0.58900481
101MAPK110.58847148
102PRKD30.58662516
103MTOR0.57956587
104SCYL20.56343968
105RPS6KA20.54943768
106PDPK10.53892698
107DMPK0.53681022
108FES0.50666548
109LYN0.49920534
110LIMK10.49572207
111TNK20.49526109
112PDGFRA0.49276458
113PRKCQ0.48764689
114IRAK10.48093488
115SIK20.47726032
116CAMK1G0.46941376
117PDK10.46623315
118CAMKK10.44331421
119KSR20.44125413
120PTK20.43127758
121FGR0.42995837
122EGFR0.42834328
123PRKG20.42373579
124ICK0.41845425
125IRAK30.41698571
126SGK30.41153289
127PRKD10.40821474
128DDR20.40571683
129MAP3K70.40024080
130ABL10.39669327
131MELK0.39613706
132AURKB0.38210556
133MARK30.38176574
134FGFR10.36845215
135MAPKAPK20.36538860
136RPS6KA60.35601841
137CHEK10.35231113
138INSR0.33628553
139PTK2B0.32917279

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.55086809
2Primary immunodeficiency_Homo sapiens_hsa053402.54975882
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.18396675
4Measles_Homo sapiens_hsa051622.11092243
5Allograft rejection_Homo sapiens_hsa053302.04745421
6T cell receptor signaling pathway_Homo sapiens_hsa046602.02314862
7Leishmaniasis_Homo sapiens_hsa051401.98328859
8Antigen processing and presentation_Homo sapiens_hsa046121.89586041
9Osteoclast differentiation_Homo sapiens_hsa043801.86863664
10Graft-versus-host disease_Homo sapiens_hsa053321.81476456
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.71191759
12Jak-STAT signaling pathway_Homo sapiens_hsa046301.68380981
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67208916
14Other glycan degradation_Homo sapiens_hsa005111.64877248
15Hematopoietic cell lineage_Homo sapiens_hsa046401.63012820
16B cell receptor signaling pathway_Homo sapiens_hsa046621.61577839
17TNF signaling pathway_Homo sapiens_hsa046681.54173868
18Acute myeloid leukemia_Homo sapiens_hsa052211.52279747
19Toxoplasmosis_Homo sapiens_hsa051451.51767078
20Herpes simplex infection_Homo sapiens_hsa051681.49262173
21Chronic myeloid leukemia_Homo sapiens_hsa052201.46302966
22Legionellosis_Homo sapiens_hsa051341.40262619
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40214763
24Hepatitis B_Homo sapiens_hsa051611.39833439
25Malaria_Homo sapiens_hsa051441.38636271
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.38636023
27DNA replication_Homo sapiens_hsa030301.38376909
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37067792
29Viral myocarditis_Homo sapiens_hsa054161.35154989
30Influenza A_Homo sapiens_hsa051641.32506524
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30502724
32Shigellosis_Homo sapiens_hsa051311.29923019
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29849975
34Asthma_Homo sapiens_hsa053101.29204509
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.26678863
36Autoimmune thyroid disease_Homo sapiens_hsa053201.26013413
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24918735
38Type I diabetes mellitus_Homo sapiens_hsa049401.23694072
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23582997
40Apoptosis_Homo sapiens_hsa042101.23480705
41Small cell lung cancer_Homo sapiens_hsa052221.22795858
42HTLV-I infection_Homo sapiens_hsa051661.22165603
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20148416
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17392901
45Salmonella infection_Homo sapiens_hsa051321.14188151
46Viral carcinogenesis_Homo sapiens_hsa052031.14113160
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11550244
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10076066
49Platelet activation_Homo sapiens_hsa046111.08388202
50Lysosome_Homo sapiens_hsa041421.08286401
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08037559
52Chemokine signaling pathway_Homo sapiens_hsa040621.07149801
53Pancreatic cancer_Homo sapiens_hsa052121.01122128
54Pertussis_Homo sapiens_hsa051331.00510598
55Tuberculosis_Homo sapiens_hsa051521.00467601
56MicroRNAs in cancer_Homo sapiens_hsa052060.97023658
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.93820465
58Epstein-Barr virus infection_Homo sapiens_hsa051690.91756674
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90755909
60Colorectal cancer_Homo sapiens_hsa052100.90313672
61Phagosome_Homo sapiens_hsa041450.89424616
62Focal adhesion_Homo sapiens_hsa045100.87943270
63Cell cycle_Homo sapiens_hsa041100.87642613
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87189467
65p53 signaling pathway_Homo sapiens_hsa041150.87095734
66Thyroid cancer_Homo sapiens_hsa052160.86858019
67Adherens junction_Homo sapiens_hsa045200.85716984
68Endocytosis_Homo sapiens_hsa041440.85540756
69HIF-1 signaling pathway_Homo sapiens_hsa040660.85159604
70Base excision repair_Homo sapiens_hsa034100.84969042
71Proteoglycans in cancer_Homo sapiens_hsa052050.84690112
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82499120
73ECM-receptor interaction_Homo sapiens_hsa045120.80823890
74Bladder cancer_Homo sapiens_hsa052190.78278888
75Prolactin signaling pathway_Homo sapiens_hsa049170.75889021
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.75429264
77VEGF signaling pathway_Homo sapiens_hsa043700.74699573
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73994319
79Hepatitis C_Homo sapiens_hsa051600.72961631
80Prion diseases_Homo sapiens_hsa050200.72947505
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72239071
82Prostate cancer_Homo sapiens_hsa052150.71345394
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70660479
84MAPK signaling pathway_Homo sapiens_hsa040100.70115051
85Rheumatoid arthritis_Homo sapiens_hsa053230.69938556
86Mismatch repair_Homo sapiens_hsa034300.69667888
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.67842489
88Notch signaling pathway_Homo sapiens_hsa043300.67744520
89RNA transport_Homo sapiens_hsa030130.66200571
90Spliceosome_Homo sapiens_hsa030400.66017702
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64642692
92Non-homologous end-joining_Homo sapiens_hsa034500.64470608
93Amoebiasis_Homo sapiens_hsa051460.64191192
94Insulin resistance_Homo sapiens_hsa049310.62872144
95Non-small cell lung cancer_Homo sapiens_hsa052230.62674775
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.61921657
97Glioma_Homo sapiens_hsa052140.61458814
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61294177
99Endometrial cancer_Homo sapiens_hsa052130.60940399
100GnRH signaling pathway_Homo sapiens_hsa049120.58707108
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58293567
102Pathways in cancer_Homo sapiens_hsa052000.57581131
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.56808051
104Dorso-ventral axis formation_Homo sapiens_hsa043200.55694664
105RNA degradation_Homo sapiens_hsa030180.55164427
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54529996
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54528848
108FoxO signaling pathway_Homo sapiens_hsa040680.54499050
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54046500
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54039124
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53824225
112One carbon pool by folate_Homo sapiens_hsa006700.53727683
113Renal cell carcinoma_Homo sapiens_hsa052110.52295420
114TGF-beta signaling pathway_Homo sapiens_hsa043500.52183586
115Choline metabolism in cancer_Homo sapiens_hsa052310.51314180
116Protein digestion and absorption_Homo sapiens_hsa049740.49922244
117Fanconi anemia pathway_Homo sapiens_hsa034600.48716986
118Ras signaling pathway_Homo sapiens_hsa040140.48415109
119Ribosome_Homo sapiens_hsa030100.47660783
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47659005
121African trypanosomiasis_Homo sapiens_hsa051430.46895582
122Staphylococcus aureus infection_Homo sapiens_hsa051500.46816258
123Rap1 signaling pathway_Homo sapiens_hsa040150.45087202
124mTOR signaling pathway_Homo sapiens_hsa041500.43934686

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