ATP10D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.28223489
2positive regulation of gamma-delta T cell activation (GO:0046645)6.05594899
3cell adhesion mediated by integrin (GO:0033627)4.60252212
4regulation of gamma-delta T cell differentiation (GO:0045586)4.58218926
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55131237
6regulation of gamma-delta T cell activation (GO:0046643)4.48766703
7positive thymic T cell selection (GO:0045059)4.29320296
8negative T cell selection (GO:0043383)4.23721857
9negative thymic T cell selection (GO:0045060)4.20119775
10antigen processing and presentation of endogenous antigen (GO:0019883)3.92383727
11skin morphogenesis (GO:0043589)3.88357139
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82557838
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.82557838
14regulation of interleukin-12 biosynthetic process (GO:0045075)3.82116360
15interferon-gamma production (GO:0032609)3.81870838
16endodermal cell differentiation (GO:0035987)3.80388604
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.75600407
18positive T cell selection (GO:0043368)3.73778843
19thymic T cell selection (GO:0045061)3.73515843
20negative regulation of cell killing (GO:0031342)3.71623940
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.71623940
22sequestering of extracellular ligand from receptor (GO:0035581)3.67353668
23regulation of fibroblast apoptotic process (GO:2000269)3.63345239
24desmosome organization (GO:0002934)3.57939939
25regulation of B cell receptor signaling pathway (GO:0050855)3.53708318
26regulation of transforming growth factor beta2 production (GO:0032909)3.49479455
27T cell selection (GO:0045058)3.49051035
28membrane raft organization (GO:0031579)3.45335790
29regulation of B cell differentiation (GO:0045577)3.42787714
30response to interleukin-15 (GO:0070672)3.42132944
31collagen fibril organization (GO:0030199)3.41318476
32regulation of alpha-beta T cell proliferation (GO:0046640)3.37554530
33wound healing, spreading of epidermal cells (GO:0035313)3.29501788
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28186798
35cell-substrate junction assembly (GO:0007044)3.26497331
36protein localization to endosome (GO:0036010)3.26026512
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23416663
38cellular response to interleukin-15 (GO:0071350)3.20506690
39negative regulation of fibroblast apoptotic process (GO:2000270)3.19482428
40hypotonic response (GO:0006971)3.19175053
41negative regulation of osteoblast proliferation (GO:0033689)3.18061153
42pericardium development (GO:0060039)3.17908919
43mesenchymal-epithelial cell signaling (GO:0060638)3.14351005
44smooth muscle tissue development (GO:0048745)3.14261410
45definitive hemopoiesis (GO:0060216)3.11905390
46response to type I interferon (GO:0034340)3.05023037
47negative regulation of phagocytosis (GO:0050765)3.03218511
48leukocyte aggregation (GO:0070486)3.02867094
49regulation of isotype switching to IgG isotypes (GO:0048302)3.02246746
50T cell migration (GO:0072678)3.02126176
51cellular response to zinc ion (GO:0071294)3.01874869
52type I interferon signaling pathway (GO:0060337)3.01459847
53cellular response to type I interferon (GO:0071357)3.01459847
54platelet-derived growth factor receptor signaling pathway (GO:0048008)3.00450801
55response to muramyl dipeptide (GO:0032495)2.99401053
56cellular response to exogenous dsRNA (GO:0071360)2.99173209
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.98130231
58myeloid dendritic cell activation (GO:0001773)2.97150035
59NIK/NF-kappaB signaling (GO:0038061)2.96671205
60glomerular basement membrane development (GO:0032836)2.96619318
61negative regulation of granulocyte differentiation (GO:0030853)2.95103741
62keratan sulfate catabolic process (GO:0042340)2.95004662
63interleukin-6-mediated signaling pathway (GO:0070102)2.94068686
64positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93977236
65regulation of MHC class I biosynthetic process (GO:0045343)2.87648078
66positive regulation of B cell differentiation (GO:0045579)2.87022266
67B cell receptor signaling pathway (GO:0050853)2.84085011
68regulation of T cell tolerance induction (GO:0002664)2.83501482
69negative regulation of T cell mediated immunity (GO:0002710)2.83199522
70positive regulation of isotype switching (GO:0045830)2.82891051
71regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82199744
72cellular response to vitamin D (GO:0071305)2.81112202
73positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78410011
74regulation of transforming growth factor beta1 production (GO:0032908)2.77781942
75nuclear pore complex assembly (GO:0051292)2.75474099
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73184486
77substrate-dependent cell migration (GO:0006929)2.72300236
78interferon-gamma-mediated signaling pathway (GO:0060333)2.71259106
79cellular response to vitamin (GO:0071295)2.71120061
80COPII vesicle coating (GO:0048208)2.69943413
81regulation of response to interferon-gamma (GO:0060330)2.69605470
82regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.69183399
83mesodermal cell differentiation (GO:0048333)2.65843202
84T-helper cell differentiation (GO:0042093)2.65445138
85CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.65445138
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63961962
87antigen receptor-mediated signaling pathway (GO:0050851)2.63512355
88wound healing, spreading of cells (GO:0044319)2.62211175
89positive regulation of DNA recombination (GO:0045911)2.62036413
90negative regulation of complement activation (GO:0045916)2.61998381
91positive regulation of interleukin-2 production (GO:0032743)2.61753663
92T cell receptor signaling pathway (GO:0050852)2.60413699
93megakaryocyte development (GO:0035855)2.60160853
94collagen metabolic process (GO:0032963)2.59754976
95positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59544948
96positive regulation of humoral immune response (GO:0002922)2.59267838
97immunoglobulin mediated immune response (GO:0016064)2.57652907
98regulation of interleukin-2 biosynthetic process (GO:0045076)2.57557915
99T cell differentiation (GO:0030217)2.57553174
100detection of molecule of bacterial origin (GO:0032490)2.57495547
101negative regulation of anoikis (GO:2000811)2.56314180
102regulation of T cell receptor signaling pathway (GO:0050856)2.55778752
103embryonic process involved in female pregnancy (GO:0060136)2.55254393
104positive regulation of tolerance induction (GO:0002645)2.54063875
105negative regulation of interleukin-12 production (GO:0032695)2.53496438
106keratinocyte proliferation (GO:0043616)2.53115409
107negative regulation of keratinocyte proliferation (GO:0010839)2.51753503
108extracellular matrix disassembly (GO:0022617)2.50515395
109retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49438079
110T cell costimulation (GO:0031295)2.48933914
111T cell homeostasis (GO:0043029)2.48619664
112regulation of isotype switching (GO:0045191)2.48552839
113collagen catabolic process (GO:0030574)2.48354976
114response to interferon-beta (GO:0035456)2.47816110
115response to protozoan (GO:0001562)2.47756797
116lymph node development (GO:0048535)2.47754413
117leukocyte cell-cell adhesion (GO:0007159)2.47353029
118negative regulation of chondrocyte differentiation (GO:0032331)2.47132556
119positive regulation of protein import into nucleus, translocation (GO:0033160)2.46871484
120myeloid dendritic cell differentiation (GO:0043011)2.45788675
121cellular response to interferon-beta (GO:0035458)2.45598171
122chondrocyte development (GO:0002063)2.45483569
123lymphocyte costimulation (GO:0031294)2.45227336
124B cell proliferation (GO:0042100)2.44681793
125pathway-restricted SMAD protein phosphorylation (GO:0060389)2.44471710
126establishment of skin barrier (GO:0061436)2.44470650
127regulation of macrophage cytokine production (GO:0010935)2.43646382
128peptide cross-linking (GO:0018149)2.42863496
129defense response to protozoan (GO:0042832)2.42861930
130gland morphogenesis (GO:0022612)2.42445189
131regulation of tolerance induction (GO:0002643)2.41963972
132alpha-beta T cell activation (GO:0046631)2.41853633
133T cell activation involved in immune response (GO:0002286)2.41556595
134ribosomal small subunit assembly (GO:0000028)2.41181404
135cellular response to ethanol (GO:0071361)2.40925739
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.40409432
137extracellular negative regulation of signal transduction (GO:1900116)2.40283677
138extracellular regulation of signal transduction (GO:1900115)2.40283677
139regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.39544047
140alpha-beta T cell differentiation involved in immune response (GO:0002293)2.39374693
141alpha-beta T cell activation involved in immune response (GO:0002287)2.39374693
142T cell differentiation involved in immune response (GO:0002292)2.39374693
143mature B cell differentiation (GO:0002335)2.39340343
144chondroitin sulfate biosynthetic process (GO:0030206)2.39316722
145blood vessel maturation (GO:0001955)2.39054160
146positive regulation of B cell activation (GO:0050871)2.39013169
147natural killer cell activation (GO:0030101)2.38855345
148type B pancreatic cell proliferation (GO:0044342)2.38122668
149cell migration involved in heart development (GO:0060973)2.36554252
150multicellular organismal macromolecule metabolic process (GO:0044259)2.36182931
151regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.35939288
152embryonic hemopoiesis (GO:0035162)2.35338917
153estrogen biosynthetic process (GO:0006703)2.34832510
154regulation of T cell mediated cytotoxicity (GO:0001914)2.34411643
155positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.34384319
156positive regulation of B cell mediated immunity (GO:0002714)2.33783769
157positive regulation of immunoglobulin mediated immune response (GO:0002891)2.33783769
158regulation of osteoblast proliferation (GO:0033688)2.33193550
159sprouting angiogenesis (GO:0002040)2.31516784
160chondrocyte proliferation (GO:0035988)2.31334286
161wound healing (GO:0042060)2.31286667
162regulation of water loss via skin (GO:0033561)2.29790767
163regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29687588
164regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.28262299
165bundle of His cell to Purkinje myocyte communication (GO:0086069)2.27606061
166multicellular organismal metabolic process (GO:0044236)2.27584893
167sphingosine metabolic process (GO:0006670)2.26505901
168multicellular organismal catabolic process (GO:0044243)2.26489262
169regulation of chemokine-mediated signaling pathway (GO:0070099)2.26345850
170negative regulation of fatty acid transport (GO:2000192)2.24605817
171negative regulation of protein activation cascade (GO:2000258)2.24243053
172renal filtration (GO:0097205)2.22490940
173integrin-mediated signaling pathway (GO:0007229)2.21940662
174glomerular visceral epithelial cell development (GO:0072015)2.21918194
175regulation of extracellular matrix disassembly (GO:0010715)2.20043298
176regulation of metalloenzyme activity (GO:0048552)2.18780907
177sphingoid metabolic process (GO:0046519)2.18681284
178surfactant homeostasis (GO:0043129)2.16672330
179vascular endothelial growth factor signaling pathway (GO:0038084)2.16419940
180positive regulation of blood vessel endothelial cell migration (GO:0043536)2.15428047
181cellular extravasation (GO:0045123)2.14228017
182positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.13751447
183barbed-end actin filament capping (GO:0051016)2.11862367
184activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.11329488
185heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.09997250
186regulation of integrin-mediated signaling pathway (GO:2001044)2.09626001
187keratinocyte differentiation (GO:0030216)2.09455941
188venous blood vessel morphogenesis (GO:0048845)2.09420660
189keratinization (GO:0031424)2.09345165
190protein localization to cell surface (GO:0034394)2.09290602
191fibril organization (GO:0097435)2.08695163
192regulation of interleukin-8 secretion (GO:2000482)2.08194168
193extracellular matrix assembly (GO:0085029)2.08085571
194regulation of keratinocyte proliferation (GO:0010837)2.06765329
195apoptotic cell clearance (GO:0043277)2.06014324
196regulation of transforming growth factor beta production (GO:0071634)2.05637136
197regulation of phospholipase A2 activity (GO:0032429)2.05430418
198regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.04813507
199positive regulation of leukocyte degranulation (GO:0043302)2.04573784

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.90185327
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.75429039
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.62689313
4E2F7_22180533_ChIP-Seq_HELA_Human4.56345971
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.03322678
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91136426
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.43282747
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.29626496
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.17694050
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.15105942
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.09662340
12SCL_19346495_ChIP-Seq_HPC-7_Human3.04018543
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.99747876
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.91768859
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.87029504
16RUNX_20019798_ChIP-Seq_JUKART_Human2.84653580
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75717534
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.65760134
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58081983
20MYC_22102868_ChIP-Seq_BL_Human2.56916234
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.40259893
22MYB_26560356_Chip-Seq_TH2_Human2.39412570
23CJUN_26792858_Chip-Seq_BT549_Human2.37129179
24MYB_26560356_Chip-Seq_TH1_Human2.33150365
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33089290
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28697860
27BRD4_25478319_ChIP-Seq_HGPS_Human2.25273868
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19976986
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.18146548
30MAF_26560356_Chip-Seq_TH1_Human2.14976424
31* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12021206
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06503603
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04180768
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02281719
35ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01067972
36GATA1_22025678_ChIP-Seq_K562_Human1.98258425
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.95714593
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95614597
39TP53_18474530_ChIP-ChIP_U2OS_Human1.95303334
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89993162
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88442481
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.88206432
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88195909
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.86847269
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.86847269
46SPI1_23547873_ChIP-Seq_NB4_Human1.84574967
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74339959
48UTX_26944678_Chip-Seq_JUKART_Human1.74049915
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.73395070
50TP53_16413492_ChIP-PET_HCT116_Human1.69624228
51TCF7_22412390_ChIP-Seq_EML_Mouse1.66394100
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64935884
53TP63_23658742_ChIP-Seq_EP156T_Human1.64153747
54AHR_22903824_ChIP-Seq_MCF-7_Human1.59939288
55VDR_21846776_ChIP-Seq_THP-1_Human1.58747463
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58547673
57* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57661901
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56587901
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56031762
60* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55814074
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53739675
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.51981981
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50866278
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.50058942
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48669887
66GATA3_27048872_Chip-Seq_THYMUS_Human1.48251425
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.46872027
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45525325
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42562181
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39466526
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39404865
72VDR_24763502_ChIP-Seq_THP-1_Human1.37165732
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.36898414
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.34285478
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31934554
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31543817
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31431670
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30979643
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.30645838
80MAF_26560356_Chip-Seq_TH2_Human1.29847422
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29760715
82PU_27001747_Chip-Seq_BMDM_Mouse1.29327651
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.28687867
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.28643893
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28631734
86SOX2_20726797_ChIP-Seq_SW620_Human1.28180027
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26755979
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25723801
89GBX2_23144817_ChIP-Seq_PC3_Human1.25430125
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21543373
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21263209
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20472844
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19488311
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.18227520
95SMAD4_21799915_ChIP-Seq_A2780_Human1.18122726
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18035800
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.17406372
98CIITA_25753668_ChIP-Seq_RAJI_Human1.17224796
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16834448
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16505148
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14571924
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14186989
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13620569
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12491007
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.10114083
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09400003
107* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09382579
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08705197
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08705197
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08705197
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08261065
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07945603
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07695392
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07275237
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07240015
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07067701
117SPI1_23127762_ChIP-Seq_K562_Human1.06841294
118P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05169274
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.05141075
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.04312930
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02815605
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02336807
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01519513
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99912944
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99650995
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99493642
127GATA3_26560356_Chip-Seq_TH2_Human0.99298772
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98757130
129CDX2_22108803_ChIP-Seq_LS180_Human0.98742812
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.98362051
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.98328644
132* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97900416
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97809112
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97491156
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97115516
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96927258
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.96879005
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95742343
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95710640
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95483365
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95308578
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94763595
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93838649
144FOXP3_21729870_ChIP-Seq_TREG_Human0.93454745
145ELK1_19687146_ChIP-ChIP_HELA_Human0.92824562
146RXR_22108803_ChIP-Seq_LS180_Human0.92777300
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92154779
148* STAT3_23295773_ChIP-Seq_U87_Human0.92092942
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91071515
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90614342
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90422615
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88920266
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88739499
154TBX20_22328084_ChIP-Seq_HEART_Mouse0.87806408
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.87806408
156TAF15_26573619_Chip-Seq_HEK293_Human0.87719145
157ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87518492
158* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87470083
159UBF1/2_26484160_Chip-Seq_HMECs_Human0.87368812
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86518941
161RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86313629
162NCOR1_26117541_ChIP-Seq_K562_Human0.84774303
163ELK3_25401928_ChIP-Seq_HUVEC_Human0.84717821
164KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83710724
165SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82773555
166SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82773555
167TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82530448
168VDR_24787735_ChIP-Seq_THP-1_Human0.82270953
169CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82219499
170VDR_23849224_ChIP-Seq_CD4+_Human0.80087784
171HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77169953
172KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75059577
173MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.72182221
174KDM2B_26808549_Chip-Seq_DND41_Human0.71096272
175STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70483838
176KDM2B_26808549_Chip-Seq_SUP-B15_Human0.69730483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.83052436
2MP0005275_abnormal_skin_tensile4.78150082
3MP0001835_abnormal_antigen_presentation3.56462053
4MP0003950_abnormal_plasma_membrane3.42562609
5MP0004272_abnormal_basement_membrane3.29173181
6MP0003763_abnormal_thymus_physiology3.17101796
7MP0003705_abnormal_hypodermis_morpholog2.93512669
8MP0005671_abnormal_response_to2.87007181
9MP0005503_abnormal_tendon_morphology2.75530429
10MP0001958_emphysema2.73711811
11MP0001790_abnormal_immune_system2.58864958
12MP0005387_immune_system_phenotype2.58864958
13MP0001800_abnormal_humoral_immune2.58416854
14MP0002166_altered_tumor_susceptibility2.53475085
15MP0005257_abnormal_intraocular_pressure2.47014194
16MP0000569_abnormal_digit_pigmentation2.44926147
17MP0002396_abnormal_hematopoietic_system2.42489535
18MP0000685_abnormal_immune_system2.41806680
19MP0009785_altered_susceptibility_to2.33929160
20MP0003191_abnormal_cellular_cholesterol2.32340979
21MP0006054_spinal_hemorrhage2.29040858
22MP0008057_abnormal_DNA_replication2.23868465
23MP0002006_tumorigenesis2.23467299
24MP0002452_abnormal_antigen_presenting2.21735683
25MP0005000_abnormal_immune_tolerance2.18520432
26MP0002009_preneoplasia2.16958255
27MP0004808_abnormal_hematopoietic_stem2.12856339
28MP0002420_abnormal_adaptive_immunity2.11393195
29MP0003724_increased_susceptibility_to2.10160013
30MP0001819_abnormal_immune_cell2.07561607
31MP0002723_abnormal_immune_serum2.07302830
32MP0001853_heart_inflammation2.04224265
33MP0002398_abnormal_bone_marrow2.01640674
34MP0005025_abnormal_response_to1.95465428
35MP0002405_respiratory_system_inflammati1.92100744
36MP0003436_decreased_susceptibility_to1.81671145
37MP0003828_pulmonary_edema1.80924611
38MP0005397_hematopoietic_system_phenotyp1.78959040
39MP0001545_abnormal_hematopoietic_system1.78959040
40MP0000716_abnormal_immune_system1.78000999
41MP0002419_abnormal_innate_immunity1.76403374
42MP0000689_abnormal_spleen_morphology1.74946102
43MP0000013_abnormal_adipose_tissue1.71724386
44MP0009780_abnormal_chondrocyte_physiolo1.71285379
45MP0009278_abnormal_bone_marrow1.71125135
46MP0002254_reproductive_system_inflammat1.69933095
47MP0002148_abnormal_hypersensitivity_rea1.68208038
48MP0002722_abnormal_immune_system1.65449107
49MP0010386_abnormal_urinary_bladder1.62369430
50MP0010234_abnormal_vibrissa_follicle1.55399225
51MP0000703_abnormal_thymus_morphology1.54592557
52MP0001873_stomach_inflammation1.53827194
53MP0010155_abnormal_intestine_physiology1.53363504
54MP0002138_abnormal_hepatobiliary_system1.53001582
55MP0002429_abnormal_blood_cell1.48539950
56MP0000579_abnormal_nail_morphology1.48114291
57MP0003300_gastrointestinal_ulcer1.46964030
58MP0010678_abnormal_skin_adnexa1.45885507
59MP0009333_abnormal_splenocyte_physiolog1.44394614
60MP0002295_abnormal_pulmonary_circulatio1.42854070
61MP0010368_abnormal_lymphatic_system1.42057968
62MP0005623_abnormal_meninges_morphology1.41767393
63MP0005075_abnormal_melanosome_morpholog1.41463194
64MP0004947_skin_inflammation1.40111921
65MP0006082_CNS_inflammation1.39796746
66MP0005164_abnormal_response_to1.37273949
67MP0002132_abnormal_respiratory_system1.33198829
68MP0003448_altered_tumor_morphology1.32286178
69MP0005670_abnormal_white_adipose1.31330174
70MP0002896_abnormal_bone_mineralization1.28124320
71MP0001845_abnormal_inflammatory_respons1.27371267
72MP0005464_abnormal_platelet_physiology1.26856486
73MP0010352_gastrointestinal_tract_polyps1.24940354
74MP0000762_abnormal_tongue_morphology1.23208405
75MP0001542_abnormal_bone_strength1.22326911
76MP0001879_abnormal_lymphatic_vessel1.22248658
77MP0003941_abnormal_skin_development1.20786248
78MP0003566_abnormal_cell_adhesion1.20069538
79MP0003252_abnormal_bile_duct1.20002390
80MP0002877_abnormal_melanocyte_morpholog1.17685914
81MP0002168_other_aberrant_phenotype1.17100315
82MP0001216_abnormal_epidermal_layer1.17094582
83MP0000566_synostosis1.15472285
84MP0008058_abnormal_DNA_repair1.15077092
85MP0000858_altered_metastatic_potential1.14682805
86MP0002796_impaired_skin_barrier1.13870864
87MP0000465_gastrointestinal_hemorrhage1.13432677
88MP0004883_abnormal_blood_vessel1.12796080
89MP0002933_joint_inflammation1.12245444
90MP0005508_abnormal_skeleton_morphology1.10672761
91MP0003786_premature_aging1.10022825
92MP0009840_abnormal_foam_cell1.06795472
93MP0008007_abnormal_cellular_replicative1.04474649
94MP0000490_abnormal_crypts_of1.04151370
95MP0005174_abnormal_tail_pigmentation1.04100913
96MP0004510_myositis1.02778404
97MP0005595_abnormal_vascular_smooth1.02139951
98MP0003303_peritoneal_inflammation0.98537713
99MP0000467_abnormal_esophagus_morphology0.98385374
100MP0000427_abnormal_hair_cycle0.98193489
101MP0003077_abnormal_cell_cycle0.97327533
102MP0005390_skeleton_phenotype0.96960479
103MP0005165_increased_susceptibility_to0.95945598
104MP0003943_abnormal_hepatobiliary_system0.94696913
105MP0004134_abnormal_chest_morphology0.93525579
106MP0001243_abnormal_dermal_layer0.93410388
107MP0002019_abnormal_tumor_incidence0.92746294
108MP0010094_abnormal_chromosome_stability0.92322304
109MP0004381_abnormal_hair_follicle0.91721819
110MP0008004_abnormal_stomach_pH0.91651572
111MP0005023_abnormal_wound_healing0.91612250
112MP0005388_respiratory_system_phenotype0.90419240
113MP0002133_abnormal_respiratory_system0.90419240
114MP0003279_aneurysm0.89164460
115MP0000733_abnormal_muscle_development0.87978392
116MP0010771_integument_phenotype0.87490829
117MP0004084_abnormal_cardiac_muscle0.86229756
118MP0000003_abnormal_adipose_tissue0.86091320
119MP0008469_abnormal_protein_level0.85064172
120MP0000767_abnormal_smooth_muscle0.84470022
121MP0009384_cardiac_valve_regurgitation0.81816758
122MP0000371_diluted_coat_color0.81580327
123MP0005171_absent_coat_pigmentation0.81354752
124MP0005058_abnormal_lysosome_morphology0.80757891
125MP0003795_abnormal_bone_structure0.76531686
126MP0004782_abnormal_surfactant_physiolog0.75871672
127MP0003091_abnormal_cell_migration0.74765906
128MP0001756_abnormal_urination0.74217629
129MP0003045_fibrosis0.74115485
130MP0005076_abnormal_cell_differentiation0.73775661
131MP0003866_abnormal_defecation0.72364608
132MP0001533_abnormal_skeleton_physiology0.72292105
133MP0002909_abnormal_adrenal_gland0.71974859
134MP0005197_abnormal_uvea_morphology0.71963681
135MP0003453_abnormal_keratinocyte_physiol0.71571033
136MP0010307_abnormal_tumor_latency0.71402077
137MP0002277_abnormal_respiratory_mucosa0.70753881
138MP0002108_abnormal_muscle_morphology0.70662931
139MP0005501_abnormal_skin_physiology0.69927168
140MP0003075_altered_response_to0.69920013
141MP0000343_altered_response_to0.68982988
142MP0001191_abnormal_skin_condition0.67903234
143MP0000015_abnormal_ear_pigmentation0.67179993
144MP0002998_abnormal_bone_remodeling0.67058155
145MP0005193_abnormal_anterior_eye0.66655745
146MP0000538_abnormal_urinary_bladder0.66253371
147MP0009053_abnormal_anal_canal0.65233451
148MP0010630_abnormal_cardiac_muscle0.63411989
149MP0001915_intracranial_hemorrhage0.63311988
150MP0000249_abnormal_blood_vessel0.63228770
151MP0002925_abnormal_cardiovascular_devel0.62831749
152MP0009250_abnormal_appendicular_skeleto0.62695677
153MP0000383_abnormal_hair_follicle0.60478504
154MP0002095_abnormal_skin_pigmentation0.59899794
155MP0000372_irregular_coat_pigmentation0.58258020
156MP0002060_abnormal_skin_morphology0.58030133
157MP0003183_abnormal_peptide_metabolism0.57776180
158MP0009697_abnormal_copulation0.56600080
159MP0001851_eye_inflammation0.56228631

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.19272990
2Atrophic scars (HP:0001075)5.11360433
3Aortic dissection (HP:0002647)4.81104343
4Protrusio acetabuli (HP:0003179)4.28734928
5Arterial tortuosity (HP:0005116)3.99073047
6Vascular tortuosity (HP:0004948)3.97086585
7Aortic aneurysm (HP:0004942)3.96852506
8Spondylolisthesis (HP:0003302)3.85266434
9Follicular hyperkeratosis (HP:0007502)3.82669068
10Onycholysis (HP:0001806)3.74486296
11Alopecia of scalp (HP:0002293)3.56557704
12Milia (HP:0001056)3.52792531
13Plantar hyperkeratosis (HP:0007556)3.51433217
14Mitral stenosis (HP:0001718)3.41817633
15Thrombocytosis (HP:0001894)3.40609956
16Recurrent bronchitis (HP:0002837)3.40264207
17Myositis (HP:0100614)3.38798315
18Agammaglobulinemia (HP:0004432)3.36893252
19Abnormality of the fingertips (HP:0001211)3.36489259
20T lymphocytopenia (HP:0005403)3.31008868
21Fragile skin (HP:0001030)3.30209346
22IgM deficiency (HP:0002850)3.29798937
23Elevated erythrocyte sedimentation rate (HP:0003565)3.28627338
24Osteolytic defects of the hand bones (HP:0009699)3.19190349
25Osteolytic defects of the phalanges of the hand (HP:0009771)3.19190349
26Peritonitis (HP:0002586)3.18594107
27Abnormality of T cell number (HP:0011839)3.16565102
28Recurrent viral infections (HP:0004429)3.12519981
29Thick nail (HP:0001805)3.09104191
30Retrobulbar optic neuritis (HP:0100654)3.06522771
31Optic neuritis (HP:0100653)3.06522771
32Recurrent abscess formation (HP:0002722)3.03882087
33Prostate neoplasm (HP:0100787)3.03458431
34Colitis (HP:0002583)3.02265997
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.01599000
36Palmoplantar hyperkeratosis (HP:0000972)3.00386813
37Syringomyelia (HP:0003396)2.95012819
38Spinal cord lesions (HP:0100561)2.95012819
39Soft skin (HP:0000977)2.93395487
40Recurrent fungal infections (HP:0002841)2.91186015
41Palmar hyperkeratosis (HP:0010765)2.88168691
42Prolonged bleeding time (HP:0003010)2.85996537
43Stomach cancer (HP:0012126)2.85672107
44Orchitis (HP:0100796)2.85245916
45Chronic otitis media (HP:0000389)2.83819932
46Spontaneous hematomas (HP:0007420)2.82724042
47Wormian bones (HP:0002645)2.81202871
48Pustule (HP:0200039)2.80185008
49Cervical subluxation (HP:0003308)2.79578778
50Inflammation of the large intestine (HP:0002037)2.79168213
51Chronic mucocutaneous candidiasis (HP:0002728)2.78377575
52Recurrent cutaneous fungal infections (HP:0011370)2.78377575
53Abnormality of the prostate (HP:0008775)2.76945657
54Lip pit (HP:0100267)2.76601509
55Abnormality of nail color (HP:0100643)2.74188278
56Abnormality of T cells (HP:0002843)2.74003853
57Keratoconjunctivitis sicca (HP:0001097)2.72452886
58Vasculitis (HP:0002633)2.70703032
59Dilatation of the ascending aorta (HP:0005111)2.69996067
60Panhypogammaglobulinemia (HP:0003139)2.67391085
61Gastrointestinal inflammation (HP:0004386)2.66410931
62Mediastinal lymphadenopathy (HP:0100721)2.62999180
63Eczematoid dermatitis (HP:0000976)2.55502379
64Meningitis (HP:0001287)2.53637693
65Abnormality of liposaccharide metabolism (HP:0010968)2.50776737
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.50776737
67Abnormality of glycolipid metabolism (HP:0010969)2.50776737
68Arterial thrombosis (HP:0004420)2.50672777
69Chromsome breakage (HP:0040012)2.48456879
70Abnormality of dentin (HP:0010299)2.46404262
71Acute myeloid leukemia (HP:0004808)2.46338843
72Recurrent sinusitis (HP:0011108)2.45131939
73Fragile nails (HP:0001808)2.43089667
74Abnormal platelet volume (HP:0011876)2.42311881
75Abnormality of the nasal mucosa (HP:0000433)2.39714622
76Bladder diverticulum (HP:0000015)2.39358548
77Cardiovascular calcification (HP:0011915)2.39003704
78Amaurosis fugax (HP:0100576)2.38808018
79Bronchitis (HP:0012387)2.38685353
80Keratoconjunctivitis (HP:0001096)2.37670132
81IgG deficiency (HP:0004315)2.36920981
82Natal tooth (HP:0000695)2.35989907
83Encephalitis (HP:0002383)2.32892991
84Nasal polyposis (HP:0100582)2.31261305
85Recurrent bacterial skin infections (HP:0005406)2.30744208
86Lymphopenia (HP:0001888)2.29433215
87Genu recurvatum (HP:0002816)2.29097875
88Hypoplasia of the iris (HP:0007676)2.27015476
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24926700
90Mucopolysacchariduria (HP:0008155)2.23171147
91Urinary glycosaminoglycan excretion (HP:0003541)2.23171147
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.22113338
93Pulmonary infiltrates (HP:0002113)2.20664308
94Right ventricular cardiomyopathy (HP:0011663)2.20181238
95Dysostosis multiplex (HP:0000943)2.16100945
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.14541407
97Blue sclerae (HP:0000592)2.14011310
98Neonatal short-limb short stature (HP:0008921)2.12252171
99Ovoid vertebral bodies (HP:0003300)2.12093329
100Overgrowth (HP:0001548)2.11854420
101IgA deficiency (HP:0002720)2.11555494
102Mitral valve prolapse (HP:0001634)2.10603698
103Recurrent pneumonia (HP:0006532)2.10116442
104Aortic regurgitation (HP:0001659)2.09838702
105Abnormality of polysaccharide metabolism (HP:0011012)2.08771136
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08771136
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08771136
108Abnormality of T cell physiology (HP:0011840)2.07700138
109Nail dystrophy (HP:0008404)2.07036224
110Vertebral compression fractures (HP:0002953)2.06114442
111Abnormality of the renal collecting system (HP:0004742)2.05890131
112Short nail (HP:0001799)2.05800578
113Lymphoma (HP:0002665)2.05659699
114Abnormality of skull ossification (HP:0002703)2.05623462
115Combined immunodeficiency (HP:0005387)2.05578040
116Epistaxis (HP:0000421)2.05134270
117Hematochezia (HP:0002573)2.03962214
118Renal cortical cysts (HP:0000803)2.02814166
119Glomerulopathy (HP:0100820)2.01884266
120Elbow flexion contracture (HP:0002987)2.01692407
121Increased mean platelet volume (HP:0011877)2.01225017
122Recurrent lower respiratory tract infections (HP:0002783)1.99253294
123Chronic diarrhea (HP:0002028)1.98530193
124Hemoptysis (HP:0002105)1.96982004
125Gingival bleeding (HP:0000225)1.96824731
126Severe combined immunodeficiency (HP:0004430)1.96351943
127Myelodysplasia (HP:0002863)1.95441755
128Striae distensae (HP:0001065)1.94140537
129Broad ribs (HP:0000885)1.93751668
130Recurrent skin infections (HP:0001581)1.93462033
131Corneal erosion (HP:0200020)1.92657678
132Corneal dystrophy (HP:0001131)1.92322227
133Thyroiditis (HP:0100646)1.91546329
134Ankle contracture (HP:0006466)1.91266710
135Absent frontal sinuses (HP:0002688)1.90687278
136Joint laxity (HP:0001388)1.90524689
137Aneurysm (HP:0002617)1.90354547
138Periodontitis (HP:0000704)1.89363600
139Cellulitis (HP:0100658)1.88110137
140Leukocytosis (HP:0001974)1.87937111
141Autoimmune thrombocytopenia (HP:0001973)1.86318949
142Widely spaced teeth (HP:0000687)1.85907270
143Petechiae (HP:0000967)1.85235867
144Portal hypertension (HP:0001409)1.84480906
145Asymmetric septal hypertrophy (HP:0001670)1.84140127
146Gastrointestinal stroma tumor (HP:0100723)1.84049480
147Long eyelashes (HP:0000527)1.82676038
148Recurrent otitis media (HP:0000403)1.82591220
149Chest pain (HP:0100749)1.80956811
150Aortic valve stenosis (HP:0001650)1.80943446
151Stomatitis (HP:0010280)1.80848659
15211 pairs of ribs (HP:0000878)1.79447435
153Leukopenia (HP:0001882)1.79399903
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79375060
155Abnormality of the hepatic vasculature (HP:0006707)1.78063996
156Tetraparesis (HP:0002273)1.77873155
157Cerebral aneurysm (HP:0004944)1.77575968
158Vacuolated lymphocytes (HP:0001922)1.77428471
159Decreased skull ossification (HP:0004331)1.76663589
160Ridged nail (HP:0001807)1.76650384
161Knee flexion contracture (HP:0006380)1.75866147
162Gastrointestinal infarctions (HP:0005244)1.75416844
163Joint stiffness (HP:0001387)1.75006413
164Abnormality of the frontal sinuses (HP:0002687)1.74700406
165Osteomyelitis (HP:0002754)1.74655054
166Skin ulcer (HP:0200042)1.73038795
167Abnormality of secondary sexual hair (HP:0009888)1.72587835
168Abnormality of the axillary hair (HP:0100134)1.72587835
169Optic nerve coloboma (HP:0000588)1.70494708
170Bilateral sensorineural hearing impairment (HP:0008619)1.70164311
171Metaphyseal dysplasia (HP:0100255)1.68344036
172Femoral bowing (HP:0002980)1.68092705
173Radial bowing (HP:0002986)1.67979806
174Erythema (HP:0010783)1.67673907
175Abnormality of the pleura (HP:0002103)1.67392661
176Hyperextensible skin (HP:0000974)1.67136850
177Xerostomia (HP:0000217)1.66337590
178Keratitis (HP:0000491)1.66169511
179Gingivitis (HP:0000230)1.64723639
180Abnormality of eosinophils (HP:0001879)1.64120055
181Delayed closure of the anterior fontanelle (HP:0001476)1.64107901
182Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.63821686
183Glucose intolerance (HP:0000833)1.63503713
184Clubbing of toes (HP:0100760)1.63462143
185Fair hair (HP:0002286)1.63227886
186Thoracolumbar scoliosis (HP:0002944)1.62969923
187Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62957520
188Intestinal fistula (HP:0100819)1.61306040
189Ectropion (HP:0000656)1.60156115
190Spinal rigidity (HP:0003306)1.59842255
191Vascular calcification (HP:0004934)1.59818030
192Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.58446418
193Delayed gross motor development (HP:0002194)1.58088665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.86115391
2TXK3.34297645
3MYLK3.26842750
4JAK32.99291616
5TYK22.82152519
6MAP3K142.80503990
7IRAK32.76773503
8PDGFRA2.55330382
9FRK2.52322809
10PIK3CG2.36901335
11IRAK42.36074935
12CDK122.32272842
13IKBKE2.23055914
14IKBKB2.13438017
15MAP2K32.06876681
16STK101.99013498
17ZAP701.95661704
18KIT1.85997412
19TEC1.84126002
20TGFBR21.83276524
21BMPR21.82290309
22DDR21.79194941
23CHUK1.78662555
24MET1.78435514
25FER1.75650014
26JAK11.74761529
27ITK1.72321091
28FGFR31.70277443
29PTK21.68517222
30MST1R1.68074074
31LMTK21.67944506
32BTK1.67570500
33EPHB21.57100552
34TBK11.52919328
35ERN11.49499582
36LATS11.49019504
37PAK21.48470532
38FGFR41.48135114
39NLK1.47757503
40STK38L1.46763628
41ZAK1.43972021
42CSF1R1.41085956
43AKT31.40507682
44BRD41.35647681
45PIM11.35382094
46LCK1.30139636
47MAP3K61.27459540
48GRK71.26891439
49ERBB31.23880399
50CAMK1D1.23159921
51NEK91.21911908
52TIE11.21585813
53PRKD21.20190918
54CSK1.19611451
55SYK1.18601346
56PTK2B1.15805816
57MAP3K31.13019965
58FLT31.11946625
59MOS1.11352296
60MAP3K121.09897096
61CLK11.09757105
62GRK61.09197161
63CDC42BPA1.08157157
64STK41.07576857
65STK381.06850869
66PRKCE1.01202707
67ACVR1B1.00274726
68HCK0.99822271
69MAP3K20.99818203
70WNK10.99561329
71MAP3K130.98398267
72RIPK10.97398044
73ADRBK10.95343965
74BLK0.91882386
75EPHB10.90386605
76PRKG20.90335856
77RPS6KA40.88676255
78ERBB40.88642322
79NUAK10.87399993
80NME20.87296130
81MARK30.84213535
82NTRK10.83805826
83ROCK20.83695152
84EEF2K0.83110057
85ROCK10.82371055
86MST40.82052849
87ABL10.81994856
88SCYL20.81910149
89GRK10.81567390
90STK240.81127443
91TGFBR10.80851569
92TRPM70.80675593
93RPS6KA60.79686154
94EIF2AK30.79482604
95TTN0.75828768
96SIK30.75820065
97NEK20.75606203
98CDK60.75495304
99KDR0.75153730
100YES10.74156619
101MAP2K60.73562865
102EIF2AK20.71302584
103LYN0.70078988
104INSR0.69928311
105LRRK20.69183390
106RPS6KC10.68288307
107RPS6KL10.68288307
108TNK20.66978617
109RPS6KB20.66449317
110SIK20.65878322
111ATR0.65272471
112MKNK20.65114878
113FGFR20.64842262
114JAK20.63408594
115PAK30.62555149
116MAP3K100.60446036
117SIK10.59896063
118PINK10.59362192
119GSK3A0.58825230
120MELK0.57397680
121TAOK30.57192144
122RET0.54980982
123MAPK70.52228725
124CDK40.52206443
125PRKCQ0.51014510
126MAP3K50.50872663
127SGK30.50719451
128PAK40.49836994
129MAPK30.48604864
130MAPKAPK20.48038515
131EGFR0.47798475
132IGF1R0.46411434
133STK30.46042355
134MATK0.45704781
135RPS6KA20.45359951
136IRAK10.44257603
137TAOK20.43208444
138PIK3CA0.42821083
139FES0.42770942
140VRK10.42750942
141ABL20.41160610
142CDK70.41029779
143MAP3K70.39143784
144PRKD10.38739307
145EPHA20.38142314
146CDK90.37889969
147SRC0.37293117
148PASK0.37254850
149PRKAA20.37000670
150RPS6KA50.35417916
151SGK20.34832201
152ATM0.34796018
153PLK40.34687801
154PDGFRB0.33320454
155MAPK10.33069430
156ADRBK20.32368691

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.68758056
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.95554411
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.61053485
4Measles_Homo sapiens_hsa051622.47742956
5Leishmaniasis_Homo sapiens_hsa051402.42663297
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35200420
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.34159232
8B cell receptor signaling pathway_Homo sapiens_hsa046622.18563204
9Hematopoietic cell lineage_Homo sapiens_hsa046402.14647245
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.09976349
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01970674
12Herpes simplex infection_Homo sapiens_hsa051682.00942174
13T cell receptor signaling pathway_Homo sapiens_hsa046601.99720492
14Graft-versus-host disease_Homo sapiens_hsa053321.90683963
15Antigen processing and presentation_Homo sapiens_hsa046121.85687718
16Osteoclast differentiation_Homo sapiens_hsa043801.84595462
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84351364
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80507185
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.78811805
20Amoebiasis_Homo sapiens_hsa051461.74285240
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74229816
22Toxoplasmosis_Homo sapiens_hsa051451.71787417
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69553432
24Dorso-ventral axis formation_Homo sapiens_hsa043201.62491863
25Influenza A_Homo sapiens_hsa051641.50126143
26Base excision repair_Homo sapiens_hsa034101.50111465
27Allograft rejection_Homo sapiens_hsa053301.49674630
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.49114770
29Mismatch repair_Homo sapiens_hsa034301.44573711
30Lysosome_Homo sapiens_hsa041421.43251877
31Homologous recombination_Homo sapiens_hsa034401.42347213
32Legionellosis_Homo sapiens_hsa051341.41310751
33Viral myocarditis_Homo sapiens_hsa054161.38939942
34Sphingolipid metabolism_Homo sapiens_hsa006001.38794127
35TNF signaling pathway_Homo sapiens_hsa046681.36068608
36Fanconi anemia pathway_Homo sapiens_hsa034601.33098935
37Malaria_Homo sapiens_hsa051441.33083575
38Protein digestion and absorption_Homo sapiens_hsa049741.32511786
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28589293
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.27817541
41Apoptosis_Homo sapiens_hsa042101.27125031
42DNA replication_Homo sapiens_hsa030301.26646278
43Acute myeloid leukemia_Homo sapiens_hsa052211.25473336
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25390026
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21450531
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21354052
47Hepatitis B_Homo sapiens_hsa051611.20399004
48HTLV-I infection_Homo sapiens_hsa051661.19905472
49Phagosome_Homo sapiens_hsa041451.18794582
50Pertussis_Homo sapiens_hsa051331.18455528
51RNA degradation_Homo sapiens_hsa030181.13950851
52p53 signaling pathway_Homo sapiens_hsa041151.13854677
53Small cell lung cancer_Homo sapiens_hsa052221.13767183
54Renal cell carcinoma_Homo sapiens_hsa052111.11061226
55Autoimmune thyroid disease_Homo sapiens_hsa053201.10875458
56Staphylococcus aureus infection_Homo sapiens_hsa051501.08129774
57Ovarian steroidogenesis_Homo sapiens_hsa049131.05189417
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04338627
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03109064
60Epstein-Barr virus infection_Homo sapiens_hsa051690.97590591
61Shigellosis_Homo sapiens_hsa051310.96730042
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96387709
63Chemokine signaling pathway_Homo sapiens_hsa040620.96181470
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96171509
65Non-homologous end-joining_Homo sapiens_hsa034500.95461496
66Dilated cardiomyopathy_Homo sapiens_hsa054140.95007265
67Hepatitis C_Homo sapiens_hsa051600.93121208
68Tuberculosis_Homo sapiens_hsa051520.91877671
69Complement and coagulation cascades_Homo sapiens_hsa046100.91139543
70Chronic myeloid leukemia_Homo sapiens_hsa052200.89668061
71Spliceosome_Homo sapiens_hsa030400.88116767
72Platelet activation_Homo sapiens_hsa046110.87236815
73Viral carcinogenesis_Homo sapiens_hsa052030.85907697
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84355004
75Type I diabetes mellitus_Homo sapiens_hsa049400.84341253
76TGF-beta signaling pathway_Homo sapiens_hsa043500.82794268
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82479697
78Melanoma_Homo sapiens_hsa052180.81949520
79Prolactin signaling pathway_Homo sapiens_hsa049170.81735884
80Ribosome_Homo sapiens_hsa030100.80787688
81Inositol phosphate metabolism_Homo sapiens_hsa005620.79004296
82Salmonella infection_Homo sapiens_hsa051320.76430444
83Nucleotide excision repair_Homo sapiens_hsa034200.76282660
84Notch signaling pathway_Homo sapiens_hsa043300.75820639
85Adherens junction_Homo sapiens_hsa045200.73080910
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.72294555
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70797621
88Renin-angiotensin system_Homo sapiens_hsa046140.70728015
89Lysine degradation_Homo sapiens_hsa003100.69619733
90Cell cycle_Homo sapiens_hsa041100.68914473
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68241466
92Renin secretion_Homo sapiens_hsa049240.67590312
93Circadian rhythm_Homo sapiens_hsa047100.66015318
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.65289642
95Prostate cancer_Homo sapiens_hsa052150.64956418
96African trypanosomiasis_Homo sapiens_hsa051430.64796887
97FoxO signaling pathway_Homo sapiens_hsa040680.64140204
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64079409
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62985508
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.60154695
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60098357
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59977775
103Glioma_Homo sapiens_hsa052140.59547085
104MicroRNAs in cancer_Homo sapiens_hsa052060.59503228
105Pathways in cancer_Homo sapiens_hsa052000.59487849
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59036183
107N-Glycan biosynthesis_Homo sapiens_hsa005100.58574778
108Pancreatic cancer_Homo sapiens_hsa052120.58179021
109Rap1 signaling pathway_Homo sapiens_hsa040150.57646545
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57367373
111Bladder cancer_Homo sapiens_hsa052190.57057225
112GnRH signaling pathway_Homo sapiens_hsa049120.55571014
113Endocytosis_Homo sapiens_hsa041440.53855481
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.52915329
115Systemic lupus erythematosus_Homo sapiens_hsa053220.51958509
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51883267
117Basal transcription factors_Homo sapiens_hsa030220.50671422
118Ras signaling pathway_Homo sapiens_hsa040140.49079886
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48217696
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47177645
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47072367
122Asthma_Homo sapiens_hsa053100.46720695
123Insulin resistance_Homo sapiens_hsa049310.46286341
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46196407
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45837805
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.44261297
127Thyroid cancer_Homo sapiens_hsa052160.42724463
128Focal adhesion_Homo sapiens_hsa045100.42481821
129Colorectal cancer_Homo sapiens_hsa052100.40685303
130One carbon pool by folate_Homo sapiens_hsa006700.40106159
131ABC transporters_Homo sapiens_hsa020100.39371838
132Other glycan degradation_Homo sapiens_hsa005110.39212312
133RNA transport_Homo sapiens_hsa030130.39135163
134Proteoglycans in cancer_Homo sapiens_hsa052050.37504639
135Rheumatoid arthritis_Homo sapiens_hsa053230.37268771
136ECM-receptor interaction_Homo sapiens_hsa045120.37188569
137Pyrimidine metabolism_Homo sapiens_hsa002400.36277933
138mRNA surveillance pathway_Homo sapiens_hsa030150.35862764
139Non-small cell lung cancer_Homo sapiens_hsa052230.35262562

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