ATP11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integral membrane ATPase. The encoded protein is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium across membranes. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)5.18009035
2phosphate ion transport (GO:0006817)4.98512803
3drug transmembrane transport (GO:0006855)4.81612869
4urate metabolic process (GO:0046415)4.59744228
5phosphate ion transmembrane transport (GO:0035435)4.49935040
6chemical homeostasis within a tissue (GO:0048875)4.01870231
7lysine catabolic process (GO:0006554)3.90004481
8lysine metabolic process (GO:0006553)3.90004481
9aminoglycoside antibiotic metabolic process (GO:0030647)3.88822409
10organic cation transport (GO:0015695)3.81427321
11drug transport (GO:0015893)3.78674136
12quaternary ammonium group transport (GO:0015697)3.63442528
13sodium ion export (GO:0071436)3.35954113
14metanephric nephron tubule development (GO:0072234)3.34393440
15metanephric tubule development (GO:0072170)3.34393440
16sodium-independent organic anion transport (GO:0043252)3.30238571
17response to mercury ion (GO:0046689)3.28896415
18excretion (GO:0007588)3.27125382
19cysteine metabolic process (GO:0006534)3.26295086
20metanephric nephron epithelium development (GO:0072243)3.23564291
21cellular extravasation (GO:0045123)3.21994699
22negative regulation of complement activation (GO:0045916)3.21982928
23detection of molecule of bacterial origin (GO:0032490)3.19248067
24cellular potassium ion homeostasis (GO:0030007)3.18223532
25growth hormone receptor signaling pathway (GO:0060396)3.17328667
26positive regulation by symbiont of host defense response (GO:0052509)3.16462005
27modulation by symbiont of host defense response (GO:0052031)3.16462005
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16462005
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16462005
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.16462005
31modulation by symbiont of host immune response (GO:0052553)3.16462005
32negative regulation of erythrocyte differentiation (GO:0045647)3.16140580
33negative regulation of protein activation cascade (GO:2000258)3.13006512
34trivalent inorganic anion homeostasis (GO:0072506)3.10380681
35phosphate ion homeostasis (GO:0055062)3.10380681
36protein localization to endosome (GO:0036010)3.06155116
37nonribosomal peptide biosynthetic process (GO:0019184)3.04710898
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.00071125
39pinocytosis (GO:0006907)2.99514680
40embryonic process involved in female pregnancy (GO:0060136)2.97518934
41response to laminar fluid shear stress (GO:0034616)2.95469805
42carnitine transport (GO:0015879)2.94910517
43amino-acid betaine transport (GO:0015838)2.94910517
44tricarboxylic acid metabolic process (GO:0072350)2.94055266
45exogenous drug catabolic process (GO:0042738)2.93836472
46aspartate family amino acid catabolic process (GO:0009068)2.93805192
47histone H3-K36 demethylation (GO:0070544)2.90826318
48metanephric epithelium development (GO:0072207)2.88961978
49glutathione biosynthetic process (GO:0006750)2.87110186
50positive regulation of gamma-delta T cell activation (GO:0046645)2.84984643
51response to peptidoglycan (GO:0032494)2.82570881
52drug catabolic process (GO:0042737)2.82349592
53positive regulation of receptor recycling (GO:0001921)2.81320017
54cellular response to growth hormone stimulus (GO:0071378)2.80819674
55peptide catabolic process (GO:0043171)2.79697592
56negative regulation of humoral immune response (GO:0002921)2.79078105
57focal adhesion assembly (GO:0048041)2.78695241
58cell-substrate adherens junction assembly (GO:0007045)2.78695241
59nephron tubule development (GO:0072080)2.78049098
60renal absorption (GO:0070293)2.77886262
61hemidesmosome assembly (GO:0031581)2.75526833
62regulation of complement activation (GO:0030449)2.75300264
63mannose metabolic process (GO:0006013)2.75241802
64negative regulation of interleukin-8 production (GO:0032717)2.71852983
65detection of other organism (GO:0098543)2.71019540
66vitamin D metabolic process (GO:0042359)2.70573594
67basement membrane organization (GO:0071711)2.69787336
68negative regulation of myotube differentiation (GO:0010832)2.67943869
69short-chain fatty acid metabolic process (GO:0046459)2.67838870
70macrophage activation involved in immune response (GO:0002281)2.67759086
71detection of external biotic stimulus (GO:0098581)2.65667985
72regulation of protein activation cascade (GO:2000257)2.64449169
73response to muramyl dipeptide (GO:0032495)2.63899993
74toxin transport (GO:1901998)2.63789473
75adherens junction assembly (GO:0034333)2.63761976
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.62104414
77pattern specification involved in kidney development (GO:0061004)2.58038769
78hypotonic response (GO:0006971)2.57244514
79potassium ion import (GO:0010107)2.56805514
80cellular hyperosmotic response (GO:0071474)2.55705674
81positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.54389200
82regulation of apoptotic cell clearance (GO:2000425)2.53917640
83angiogenesis involved in wound healing (GO:0060055)2.53810630
84glyoxylate metabolic process (GO:0046487)2.50769468
85cellular sodium ion homeostasis (GO:0006883)2.49531106
86adhesion of symbiont to host cell (GO:0044650)2.49007215
87virion attachment to host cell (GO:0019062)2.49007215
88renal tubule development (GO:0061326)2.47425843
89positive regulation of osteoblast proliferation (GO:0033690)2.47151972
90cellular response to vitamin (GO:0071295)2.46903638
91potassium ion homeostasis (GO:0055075)2.45957231
92response to growth hormone (GO:0060416)2.45016659
93epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44610685
94creatine metabolic process (GO:0006600)2.44547986
95regulation of necroptotic process (GO:0060544)2.44494768
96sodium ion homeostasis (GO:0055078)2.43492804
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42431601
98detection of bacterium (GO:0016045)2.42386864
99regulation of gamma-delta T cell activation (GO:0046643)2.42214574
100membrane repolarization during action potential (GO:0086011)2.42189102
101cellular response to vitamin D (GO:0071305)2.41260808
102positive regulation of Rap GTPase activity (GO:0032854)2.41243214
103membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.40221347
104atrioventricular valve morphogenesis (GO:0003181)2.39678122
105detection of biotic stimulus (GO:0009595)2.39509285
106valine metabolic process (GO:0006573)2.39341077
107neutrophil activation involved in immune response (GO:0002283)2.39077781
108renal filtration (GO:0097205)2.38534388
109production of molecular mediator involved in inflammatory response (GO:0002532)2.34694193
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.33548539
111cell adhesion mediated by integrin (GO:0033627)2.33506865
112fatty acid beta-oxidation (GO:0006635)2.33041491
113regulation of leukocyte degranulation (GO:0043300)2.32913417
114positive regulation of phagocytosis (GO:0050766)2.32628120
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.32519327
116fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.32495492
117histone H3-K9 demethylation (GO:0033169)2.30027387
118myelin maintenance (GO:0043217)2.29738404
119positive regulation of cellular amide metabolic process (GO:0034250)2.29345410
120regulation of cholesterol homeostasis (GO:2000188)2.28647959
121branched-chain amino acid metabolic process (GO:0009081)2.28391449
1222-oxoglutarate metabolic process (GO:0006103)2.26541659
123nephron epithelium development (GO:0072009)2.25458207
124peptide biosynthetic process (GO:0043043)2.25448675
125negative regulation of cell killing (GO:0031342)2.25099878
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.25099878
127branching involved in salivary gland morphogenesis (GO:0060445)2.24755797
128iron ion import (GO:0097286)2.23768255
129receptor catabolic process (GO:0032801)2.23199023
130collecting duct development (GO:0072044)2.21947604
131membrane repolarization (GO:0086009)2.21417894
132regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21188889
133response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.20388176
134response to host (GO:0075136)2.20388176
135response to host defenses (GO:0052200)2.20388176
136epithelial cell-cell adhesion (GO:0090136)2.20357933
137paraxial mesoderm development (GO:0048339)2.20190976
138fibroblast migration (GO:0010761)2.20102174
139regulation of hippo signaling (GO:0035330)2.19774059
140macrophage activation (GO:0042116)2.19769910
141cell communication by electrical coupling (GO:0010644)2.19480283
142response to parathyroid hormone (GO:0071107)2.19172671
143histone lysine demethylation (GO:0070076)2.18980418
144plasma lipoprotein particle assembly (GO:0034377)2.18558036
145plasma membrane repair (GO:0001778)2.18104967
146regulation of gamma-delta T cell differentiation (GO:0045586)2.17913231
147cell-cell junction maintenance (GO:0045217)2.17248594
148germinal center formation (GO:0002467)2.17168613
149bundle of His cell to Purkinje myocyte communication (GO:0086069)2.16047463
150negative regulation of fatty acid transport (GO:2000192)2.15959876
151negative regulation of toll-like receptor signaling pathway (GO:0034122)2.15759131
152apoptotic cell clearance (GO:0043277)2.15383479
153negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.14964620
154cell communication involved in cardiac conduction (GO:0086065)2.14096714
155regulation of B cell receptor signaling pathway (GO:0050855)2.13147493
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13127568
157response to phenylpropanoid (GO:0080184)2.12115463
158cell-substrate junction assembly (GO:0007044)2.11172067
159fatty acid oxidation (GO:0019395)2.10619800
160cellular modified amino acid catabolic process (GO:0042219)2.10580446
161regulation of interferon-beta biosynthetic process (GO:0045357)2.10234928
162cellular response to reactive nitrogen species (GO:1902170)2.09627122
163regulation of ARF protein signal transduction (GO:0032012)2.09519764
164camera-type eye morphogenesis (GO:0048593)2.09456019
165relaxation of cardiac muscle (GO:0055119)2.09312934
166sodium ion transport (GO:0006814)2.09151352
167neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.08994442
168response to host immune response (GO:0052572)2.08171685
169response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.08171685
170glomerular filtration (GO:0003094)2.08044364
171nephron tubule formation (GO:0072079)2.07661763
172regulation of Cdc42 GTPase activity (GO:0043088)2.07568736
173hormone catabolic process (GO:0042447)2.07453479
174acetyl-CoA metabolic process (GO:0006084)2.07407535
175cytoplasmic mRNA processing body assembly (GO:0033962)2.07293971
176lipid oxidation (GO:0034440)2.07207668
177phospholipid scrambling (GO:0017121)2.07150401
178negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.07094852
179regulation of clathrin-mediated endocytosis (GO:2000369)2.06953058
180protein-lipid complex assembly (GO:0065005)2.05609959
181lung lobe morphogenesis (GO:0060463)2.05608614
182stress fiber assembly (GO:0043149)2.05370760
183beta-amyloid metabolic process (GO:0050435)2.05339995
184regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.05156947
185insulin-like growth factor receptor signaling pathway (GO:0048009)2.05154414
186leukocyte migration involved in inflammatory response (GO:0002523)2.05142412
187semaphorin-plexin signaling pathway (GO:0071526)2.04765549
188cellular response to thyroid hormone stimulus (GO:0097067)2.04013605
189antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.03943531
190histone demethylation (GO:0016577)2.03423245
191regulation of mast cell degranulation (GO:0043304)2.02942303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human2.90357507
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.89501954
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.57522462
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.35403456
5TCF7_22412390_ChIP-Seq_EML_Mouse2.13148946
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.11756753
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08612837
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07217330
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97632300
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97015651
11EP300_21415370_ChIP-Seq_HL-1_Mouse1.96921504
12* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96818008
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91566785
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91059474
15MYC_22102868_ChIP-Seq_BL_Human1.90940290
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.90886527
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87509278
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.86209053
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83771820
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82778285
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82500933
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.80443296
23CLOCK_20551151_ChIP-Seq_293T_Human1.79539425
24SPI1_23127762_ChIP-Seq_K562_Human1.75842941
25KDM2B_26808549_Chip-Seq_DND41_Human1.75440697
26VDR_21846776_ChIP-Seq_THP-1_Human1.74921570
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72465170
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.71757872
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69530815
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69304897
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68975668
32AHR_22903824_ChIP-Seq_MCF-7_Human1.68890680
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.65725037
34VDR_24763502_ChIP-Seq_THP-1_Human1.61815402
35GATA1_19941827_ChIP-Seq_MEL_Mouse1.59908132
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.59018286
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57200219
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.57061830
39* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54961615
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54470629
41SCL_19346495_ChIP-Seq_HPC-7_Human1.53691339
42* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52456086
43DROSHA_22980978_ChIP-Seq_HELA_Human1.49197411
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48991893
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47458904
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46431232
47* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45527280
48* LXR_22292898_ChIP-Seq_THP-1_Human1.44825548
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44077068
50* ARNT_22903824_ChIP-Seq_MCF-7_Human1.41893456
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41256525
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40850363
53* TBX20_22080862_ChIP-Seq_HEART_Mouse1.40824576
54* TBX20_22328084_ChIP-Seq_HEART_Mouse1.40824576
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.39244068
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38911302
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38819096
58CJUN_26792858_Chip-Seq_BT549_Human1.38395769
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.37762591
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.37740603
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37714541
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.36735211
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35980351
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35148421
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35122506
66* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35045614
67* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35045614
68* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34818760
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32856382
70GATA1_22025678_ChIP-Seq_K562_Human1.31968860
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30935955
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30902699
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.29903867
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29224285
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.28928749
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28191866
77* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27924094
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26820495
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.26315310
80* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26037704
81GATA1_19941826_ChIP-Seq_K562_Human1.25880302
82* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25779577
83RUNX_20019798_ChIP-Seq_JUKART_Human1.25762051
84* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23467223
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23430877
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23430877
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23412240
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20827560
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20524279
90SOX2_20726797_ChIP-Seq_SW620_Human1.19959700
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.19181547
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18555235
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18111315
94* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17311234
95KDM2B_26808549_Chip-Seq_K562_Human1.15709465
96MAF_26560356_Chip-Seq_TH1_Human1.13817337
97IRF8_21731497_ChIP-ChIP_J774_Mouse1.13332385
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12288644
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11678924
100JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11391837
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10925227
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10872244
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.09254719
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08821323
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08571171
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.07592569
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07347667
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.05504172
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05356724
110GATA2_19941826_ChIP-Seq_K562_Human1.05059580
111* RACK7_27058665_Chip-Seq_MCF-7_Human1.04330419
112ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04233256
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03841703
114AR_21572438_ChIP-Seq_LNCaP_Human1.03724279
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02829946
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.02552204
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.01769831
118TP63_23658742_ChIP-Seq_EP156T_Human1.00878225
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00565869
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.00134981
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00046568
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99719356
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99380839
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98503391
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.98280974
126RXR_22108803_ChIP-Seq_LS180_Human0.97154565
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96979751
128PU_27001747_Chip-Seq_BMDM_Mouse0.96529593
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95750171
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95259386
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95259386
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94812687
133* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94562177
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94071669
135* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93461976
136GATA4_25053715_ChIP-Seq_YYC3_Human0.93185218
137KLF5_25053715_ChIP-Seq_YYC3_Human0.93055596
138ZNF263_19887448_ChIP-Seq_K562_Human0.92992611
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92797131
140RNF2_27304074_Chip-Seq_ESCs_Mouse0.92789175
141TP53_18474530_ChIP-ChIP_U2OS_Human0.91183947
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90831673
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90595929
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90332337
145GBX2_23144817_ChIP-Seq_PC3_Human0.88416355
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87703946
147VDR_24787735_ChIP-Seq_THP-1_Human0.86961764
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86466087
149TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86296209
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85999479
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85657184
152STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83440623
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83329884
154TCF4_18268006_ChIP-ChIP_LS174T_Human0.83121222
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.82994650
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82614862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001958_emphysema4.43303922
2MP0004043_abnormal_pH_regulation3.80519114
3MP0002138_abnormal_hepatobiliary_system2.99214064
4MP0005360_urolithiasis2.94038605
5MP0005451_abnormal_body_composition2.83714933
6MP0005076_abnormal_cell_differentiation2.65857724
7MP0001765_abnormal_ion_homeostasis2.43614153
8MP0003303_peritoneal_inflammation2.42601010
9MP0008438_abnormal_cutaneous_collagen2.41327253
10MP0004782_abnormal_surfactant_physiolog2.35458196
11MP0005377_hearing/vestibular/ear_phenot2.34928498
12MP0003878_abnormal_ear_physiology2.34928498
13MP0004019_abnormal_vitamin_homeostasis2.33504147
14MP0005409_darkened_coat_color2.23268755
15MP0003724_increased_susceptibility_to2.18810381
16MP0003828_pulmonary_edema2.17635780
17MP0010234_abnormal_vibrissa_follicle2.16707296
18MP0004272_abnormal_basement_membrane2.16595350
19MP0005332_abnormal_amino_acid2.15823615
20MP0009643_abnormal_urine_homeostasis2.11989435
21MP0005058_abnormal_lysosome_morphology2.11506443
22MP0008260_abnormal_autophagy2.08292717
23MP0003436_decreased_susceptibility_to2.07051436
24MP0003705_abnormal_hypodermis_morpholog2.03881001
25MP0003300_gastrointestinal_ulcer2.00962472
26MP0004885_abnormal_endolymph1.95397730
27MP0005275_abnormal_skin_tensile1.86437406
28MP0001756_abnormal_urination1.81143359
29MP0003183_abnormal_peptide_metabolism1.79836535
30MP0005623_abnormal_meninges_morphology1.73660744
31MP0004084_abnormal_cardiac_muscle1.67350356
32MP0002419_abnormal_innate_immunity1.65780720
33MP0001851_eye_inflammation1.64225201
34MP0002136_abnormal_kidney_physiology1.63594526
35MP0003045_fibrosis1.62037669
36MP0009278_abnormal_bone_marrow1.61084282
37MP0002877_abnormal_melanocyte_morpholog1.60523632
38MP0002998_abnormal_bone_remodeling1.56690406
39MP0003566_abnormal_cell_adhesion1.56329287
40MP0001177_atelectasis1.55196161
41MP0010352_gastrointestinal_tract_polyps1.54473239
42MP0002168_other_aberrant_phenotype1.54374313
43MP0002295_abnormal_pulmonary_circulatio1.51996085
44MP0003195_calcinosis1.49091070
45MP0004858_abnormal_nervous_system1.49082226
46MP0003453_abnormal_keratinocyte_physiol1.47714384
47MP0002396_abnormal_hematopoietic_system1.46367300
48MP0001915_intracranial_hemorrhage1.43548239
49MP0009780_abnormal_chondrocyte_physiolo1.42583076
50MP0010630_abnormal_cardiac_muscle1.41938975
51MP0003950_abnormal_plasma_membrane1.39214733
52MP0008961_abnormal_basal_metabolism1.39099983
53MP0000534_abnormal_ureter_morphology1.38043760
54MP0003252_abnormal_bile_duct1.37916619
55MP0004947_skin_inflammation1.37853478
56MP0000537_abnormal_urethra_morphology1.36914393
57MP0004036_abnormal_muscle_relaxation1.36903615
58MP0005464_abnormal_platelet_physiology1.36108016
59MP0010678_abnormal_skin_adnexa1.33993898
60MP0002896_abnormal_bone_mineralization1.31931736
61MP0005636_abnormal_mineral_homeostasis1.30882055
62MP0005023_abnormal_wound_healing1.28859120
63MP0003329_amyloid_beta_deposits1.26559727
64MP0000751_myopathy1.25818805
65MP0002139_abnormal_hepatobiliary_system1.25695972
66MP0009384_cardiac_valve_regurgitation1.23322220
67MP0005388_respiratory_system_phenotype1.22064096
68MP0002133_abnormal_respiratory_system1.22064096
69MP0010368_abnormal_lymphatic_system1.20551866
70MP0000767_abnormal_smooth_muscle1.16447386
71MP0008775_abnormal_heart_ventricle1.14733752
72MP0005025_abnormal_response_to1.14447477
73MP0005164_abnormal_response_to1.11739928
74MP0002925_abnormal_cardiovascular_devel1.11451538
75MP0002405_respiratory_system_inflammati1.11300450
76MP0008004_abnormal_stomach_pH1.10810865
77MP0000920_abnormal_myelination1.10610023
78MP0002796_impaired_skin_barrier1.09858409
79MP0005666_abnormal_adipose_tissue1.08986403
80MP0004883_abnormal_blood_vessel1.07127391
81MP0000858_altered_metastatic_potential1.07112124
82MP0001299_abnormal_eye_distance/1.07077726
83MP0003191_abnormal_cellular_cholesterol1.04053428
84MP0000685_abnormal_immune_system1.03813241
85MP0001533_abnormal_skeleton_physiology1.02427515
86MP0003091_abnormal_cell_migration1.02419490
87MP0005551_abnormal_eye_electrophysiolog1.01520078
88MP0001790_abnormal_immune_system1.00921398
89MP0005387_immune_system_phenotype1.00921398
90MP0008875_abnormal_xenobiotic_pharmacok1.00356813
91MP0003279_aneurysm1.00286637
92MP0001346_abnormal_lacrimal_gland1.00121612
93MP0002086_abnormal_extraembryonic_tissu0.98968955
94MP0000747_muscle_weakness0.98183148
95MP0009840_abnormal_foam_cell0.97795427
96MP0004808_abnormal_hematopoietic_stem0.97509895
97MP0004264_abnormal_extraembryonic_tissu0.97315883
98MP0004233_abnormal_muscle_weight0.97141686
99MP0001545_abnormal_hematopoietic_system0.96720243
100MP0005397_hematopoietic_system_phenotyp0.96720243
101MP0005167_abnormal_blood-brain_barrier0.95781754
102MP0003283_abnormal_digestive_organ0.95054686
103MP0001849_ear_inflammation0.94981063
104MP0001614_abnormal_blood_vessel0.94499396
105MP0004510_myositis0.94449940
106MP0002166_altered_tumor_susceptibility0.91807542
107MP0001175_abnormal_lung_morphology0.91747898
108MP0000538_abnormal_urinary_bladder0.91242273
109MP0002972_abnormal_cardiac_muscle0.90641087
110MP0005375_adipose_tissue_phenotype0.90492082
111MP0003943_abnormal_hepatobiliary_system0.89851502
112MP0004185_abnormal_adipocyte_glucose0.88773007
113MP0005621_abnormal_cell_physiology0.88324534
114MP0005620_abnormal_muscle_contractility0.87601179
115MP0002089_abnormal_postnatal_growth/wei0.87357359
116MP0002090_abnormal_vision0.87071508
117MP0005083_abnormal_biliary_tract0.87031371
118MP0000249_abnormal_blood_vessel0.86431402
119MP0003656_abnormal_erythrocyte_physiolo0.86358477
120MP0002128_abnormal_blood_circulation0.85139778
121MP0003984_embryonic_growth_retardation0.84374862
122MP0000383_abnormal_hair_follicle0.84136163
123MP0002837_dystrophic_cardiac_calcinosis0.83971104
124MP0006138_congestive_heart_failure0.83573589
125MP0001835_abnormal_antigen_presentation0.83500116
126MP0000733_abnormal_muscle_development0.83203352
127MP0003172_abnormal_lysosome_physiology0.83098012
128MP0002452_abnormal_antigen_presenting0.82571876
129MP0004087_abnormal_muscle_fiber0.82292042
130MP0003075_altered_response_to0.82195748
131MP0002108_abnormal_muscle_morphology0.81962108
132MP0010155_abnormal_intestine_physiology0.81649669
133MP0000678_abnormal_parathyroid_gland0.81599716
134MP0006082_CNS_inflammation0.80220985
135MP0005310_abnormal_salivary_gland0.79941902
136MP0002088_abnormal_embryonic_growth/wei0.79563551
137MP0000566_synostosis0.79359343
138MP0000230_abnormal_systemic_arterial0.79095132
139MP0005330_cardiomyopathy0.78999288
140MP0002254_reproductive_system_inflammat0.78961261
141MP0001485_abnormal_pinna_reflex0.77923931
142MP0005408_hypopigmentation0.77820963
143MP0002928_abnormal_bile_duct0.77076848
144MP0002009_preneoplasia0.77004886
145MP0004215_abnormal_myocardial_fiber0.76409410
146MP0005503_abnormal_tendon_morphology0.75874842
147MP0002420_abnormal_adaptive_immunity0.75559297
148MP0001819_abnormal_immune_cell0.75068136
149MP0000762_abnormal_tongue_morphology0.74732344
150MP0003634_abnormal_glial_cell0.74173716
151MP0002723_abnormal_immune_serum0.74054238
152MP0001800_abnormal_humoral_immune0.73953296
153MP0002006_tumorigenesis0.73940420
154MP0004130_abnormal_muscle_cell0.73137018
155MP0001879_abnormal_lymphatic_vessel0.73059796
156MP0003690_abnormal_glial_cell0.72319610
157MP0003115_abnormal_respiratory_system0.70850072
158MP0004484_altered_response_of0.69775362
159MP0000003_abnormal_adipose_tissue0.68802868
160MP0000604_amyloidosis0.67838452
161MP0000579_abnormal_nail_morphology0.67193038
162MP0002135_abnormal_kidney_morphology0.66799183

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.70611999
2Increased circulating renin level (HP:0000848)5.33322779
3Hypokalemic alkalosis (HP:0001949)5.25546685
4Gout (HP:0001997)5.20560367
5Abnormality of chloride homeostasis (HP:0011422)4.92834092
6Metabolic alkalosis (HP:0200114)4.85380971
7Hypomagnesemia (HP:0002917)4.53546148
8Renal salt wasting (HP:0000127)4.25735875
9Abnormality of renal excretion (HP:0011036)4.15462362
10Polyuria (HP:0000103)4.03789292
11Abnormality of the fingertips (HP:0001211)3.96773280
12Abnormal urine output (HP:0012590)3.95248836
13Hyperaldosteronism (HP:0000859)3.87449654
14Abnormality of renin-angiotensin system (HP:0000847)3.79644065
15Abnormality of magnesium homeostasis (HP:0004921)3.55415689
16Interstitial pulmonary disease (HP:0006530)3.49989963
17Increased purine levels (HP:0004368)3.47931649
18Hyperuricemia (HP:0002149)3.47931649
19Eczematoid dermatitis (HP:0000976)3.45339603
20Abnormal drinking behavior (HP:0030082)3.42299435
21Polydipsia (HP:0001959)3.42299435
22Tetany (HP:0001281)3.38064628
23Deep venous thrombosis (HP:0002625)3.18925031
24Proximal tubulopathy (HP:0000114)3.11278518
25Recurrent gram-negative bacterial infections (HP:0005420)3.05556776
26Abnormality of purine metabolism (HP:0004352)2.93881876
27Tubulointerstitial fibrosis (HP:0005576)2.90806333
28Hypercalciuria (HP:0002150)2.84409474
29Broad metatarsal (HP:0001783)2.75738778
30Hypokalemia (HP:0002900)2.74820762
31Abnormality of potassium homeostasis (HP:0011042)2.71006102
32Alkalosis (HP:0001948)2.69877657
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60396190
34Cardiovascular calcification (HP:0011915)2.51947332
35Potter facies (HP:0002009)2.50802263
36Facial shape deformation (HP:0011334)2.50802263
37Muscle fiber splitting (HP:0003555)2.50017166
38Hyperkalemia (HP:0002153)2.48129242
39Vascular calcification (HP:0004934)2.47331273
40Orchitis (HP:0100796)2.45565935
41Abnormality of macrophages (HP:0004311)2.44208057
42Ketoacidosis (HP:0001993)2.42929898
43Esophageal varix (HP:0002040)2.40172288
44Recurrent abscess formation (HP:0002722)2.38710221
45Flat acetabular roof (HP:0003180)2.37434647
46Hypoplasia of the iris (HP:0007676)2.33603859
47Subacute progressive viral hepatitis (HP:0006572)2.33270580
48Tachypnea (HP:0002789)2.31964771
49Optic neuritis (HP:0100653)2.31568356
50Retrobulbar optic neuritis (HP:0100654)2.31568356
51Thin bony cortex (HP:0002753)2.27301135
52Hyporeflexia of lower limbs (HP:0002600)2.22954254
53Lymphangioma (HP:0100764)2.22272738
54Myositis (HP:0100614)2.20867947
55Hydroxyprolinuria (HP:0003080)2.19915892
56Abnormality of proline metabolism (HP:0010907)2.19915892
57Atrophic scars (HP:0001075)2.19418673
58Glomerulosclerosis (HP:0000096)2.17851688
59Hemorrhage of the eye (HP:0011885)2.15851825
60Adrenal overactivity (HP:0002717)2.15592154
61Gingivitis (HP:0000230)2.14900797
62Prolonged bleeding time (HP:0003010)2.14804733
63Abnormality of the common coagulation pathway (HP:0010990)2.14748403
64Renal tubular acidosis (HP:0001947)2.14731508
65Recurrent bacterial skin infections (HP:0005406)2.14480154
66Spontaneous hematomas (HP:0007420)2.14222984
67Broad face (HP:0000283)2.13794821
68Shallow orbits (HP:0000586)2.13373925
69Visceral angiomatosis (HP:0100761)2.12144903
70Hyperglycinuria (HP:0003108)2.12077230
71Complement deficiency (HP:0004431)2.11996592
72Premature rupture of membranes (HP:0001788)2.10792641
73Menorrhagia (HP:0000132)2.08967729
74Abnormality of complement system (HP:0005339)2.08638146
75Cerebral aneurysm (HP:0004944)2.06109341
76Gingival bleeding (HP:0000225)2.05978284
77Right ventricular cardiomyopathy (HP:0011663)2.03462716
78Obstructive sleep apnea (HP:0002870)2.02832733
79Myocardial infarction (HP:0001658)2.02695278
80Tubular atrophy (HP:0000092)2.02122426
81Increased cerebral lipofuscin (HP:0011813)2.02050275
82Systemic lupus erythematosus (HP:0002725)1.97501395
83Persistence of primary teeth (HP:0006335)1.95609229
84Hemangiomatosis (HP:0007461)1.95202396
85Macroorchidism (HP:0000053)1.94974427
86Dislocated radial head (HP:0003083)1.94839474
87Neurofibrillary tangles (HP:0002185)1.94682684
88Joint hemorrhage (HP:0005261)1.94001939
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93707960
90Dysmetric saccades (HP:0000641)1.93477058
91Aortic aneurysm (HP:0004942)1.93398156
92Distal upper limb amyotrophy (HP:0007149)1.93224187
93Upper limb amyotrophy (HP:0009129)1.93224187
94Glomerulonephritis (HP:0000099)1.93211788
95Nephrolithiasis (HP:0000787)1.89908647
96Nephrocalcinosis (HP:0000121)1.89112885
97Ulnar bowing (HP:0003031)1.87017818
98Aortic dissection (HP:0002647)1.85501911
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84433721
100Increased connective tissue (HP:0009025)1.83969287
101Bilateral sensorineural hearing impairment (HP:0008619)1.83056234
102Arterial tortuosity (HP:0005116)1.82955828
103Long eyelashes (HP:0000527)1.82924840
104Turricephaly (HP:0000262)1.82719557
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.82274426
106Broad palm (HP:0001169)1.81687172
107Vascular tortuosity (HP:0004948)1.81577732
108Focal segmental glomerulosclerosis (HP:0000097)1.81395368
109Epistaxis (HP:0000421)1.80231535
110Long toe (HP:0010511)1.79913436
111Amyloidosis (HP:0011034)1.79131384
112Abnormality of glycine metabolism (HP:0010895)1.78791336
113Abnormality of serine family amino acid metabolism (HP:0010894)1.78791336
114Cervical subluxation (HP:0003308)1.78457049
115Dehydration (HP:0001944)1.78007114
116Polycythemia (HP:0001901)1.77916505
117Gastrointestinal infarctions (HP:0005244)1.77333560
118Purpura (HP:0000979)1.76801124
119Abnormality of the thoracic spine (HP:0100711)1.76548936
120Scapular winging (HP:0003691)1.76459306
121Hyperacusis (HP:0010780)1.76433426
122Hand muscle atrophy (HP:0009130)1.75964032
123Germ cell neoplasia (HP:0100728)1.75577123
124Arterial thrombosis (HP:0004420)1.75114573
125Congenital stationary night blindness (HP:0007642)1.74562325
126Metaphyseal cupping (HP:0003021)1.74048282
127Tubulointerstitial abnormality (HP:0001969)1.73981410
128Disproportionate tall stature (HP:0001519)1.73632984
129Ketosis (HP:0001946)1.73214855
130Aplasia of the phalanges of the hand (HP:0009802)1.73156438
131Aplasia involving bones of the extremities (HP:0009825)1.73156438
132Aplasia involving bones of the upper limbs (HP:0009823)1.73156438
133Submucous cleft hard palate (HP:0000176)1.72916866
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.72868321
135Mitral valve prolapse (HP:0001634)1.72719451
136Abnormality of the radial head (HP:0003995)1.72688463
137Asymmetry of the thorax (HP:0001555)1.72350402
138Cerebral inclusion bodies (HP:0100314)1.71702245
139Segmental peripheral demyelination/remyelination (HP:0003481)1.71568497
140Decreased circulating renin level (HP:0003351)1.71164508
141Keratoconjunctivitis sicca (HP:0001097)1.70969240
142Abnormality of the lumbar spine (HP:0100712)1.68592619
143Stridor (HP:0010307)1.68464849
144Vertebral arch anomaly (HP:0008438)1.67274891
145Distal lower limb amyotrophy (HP:0008944)1.67137435
146Abnormality of sodium homeostasis (HP:0010931)1.65948935
147Axonal loss (HP:0003447)1.64281862
148Generalized aminoaciduria (HP:0002909)1.63822554
149Cellulitis (HP:0100658)1.63769940
150Bronchomalacia (HP:0002780)1.61344473
151Increased neuronal autofluorescent lipopigment (HP:0002074)1.61272729
152Loss of speech (HP:0002371)1.61191841
153Advanced eruption of teeth (HP:0006288)1.60904554
154Aneurysm (HP:0002617)1.60253515
155Knee flexion contracture (HP:0006380)1.59799161
156Pathologic fracture (HP:0002756)1.58501262
157Mitral stenosis (HP:0001718)1.58321566
158Buphthalmos (HP:0000557)1.58197859
159Osteolytic defects of the hand bones (HP:0009699)1.57625037
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.57625037
161Ventricular tachycardia (HP:0004756)1.57563438
162Rickets (HP:0002748)1.57256163
163Skull defect (HP:0001362)1.57234052
164Onion bulb formation (HP:0003383)1.57075520
165Chondrocalcinosis (HP:0000934)1.56944972
166Ankyloglossia (HP:0010296)1.56837862
167Abnormality of the peritoneum (HP:0002585)1.56646705
168Thoracic kyphosis (HP:0002942)1.56432784
169Craniofacial hyperostosis (HP:0004493)1.56331219
170Keratoconjunctivitis (HP:0001096)1.56275831
171Central scotoma (HP:0000603)1.55738046
172Abnormality of incisor morphology (HP:0011063)1.55509915
173Hypotension (HP:0002615)1.54735736
174Viral hepatitis (HP:0006562)1.53971559
175Abnormality of the nasal septum (HP:0000419)1.53462215
176Pulmonary embolism (HP:0002204)1.53009571
177Colitis (HP:0002583)1.52706935
178Recurrent skin infections (HP:0001581)1.52400265
179Increased IgE level (HP:0003212)1.51710463
180Narrow palate (HP:0000189)1.51405409
181Acne (HP:0001061)1.51064527
182Mucopolysacchariduria (HP:0008155)1.50998111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.26107265
2STK393.99934230
3OXSR13.92383520
4CDK123.47761488
5WNK33.18494404
6EPHB13.13478096
7PRPF4B2.65901327
8RIPK42.26198581
9LATS12.20812403
10TRIB32.13052868
11WNK12.11959862
12RIPK12.05309291
13EEF2K2.03190120
14TTN2.02090458
15FGFR22.00580215
16DDR21.80879613
17BLK1.78730700
18LMTK21.75898602
19MAP3K131.75386576
20MAP2K31.75069391
21FER1.69655052
22SMG11.59403506
23STK38L1.48284669
24MST1R1.47288013
25CSK1.46999394
26PTK61.44095524
27EPHA31.42536200
28ZAP701.40392667
29LRRK21.39090669
30STK381.38824743
31MET1.37771525
32PDGFRA1.36619293
33TYK21.36014852
34PTK21.34136563
35SIK11.31150251
36CAMK1G1.27116680
37FGFR41.26414799
38SGK2231.25505560
39SGK4941.25505560
40PAK31.20594777
41FGR1.19140514
42MAP3K61.16342575
43MAP3K21.16202715
44NTRK11.13586724
45MAP3K141.12860058
46BMX1.12828182
47DMPK1.11872792
48YES11.10965215
49MAP3K11.09376092
50BRD41.08436061
51FES1.08147608
52PKN21.07132467
53MAP3K71.03396650
54TIE11.01989183
55PDGFRB0.99916536
56PDK30.97887964
57PDK40.97887964
58CAMK1D0.96665691
59MAP4K10.95886073
60MAP3K100.95118497
61TGFBR20.94751445
62PDK20.89973827
63PAK40.89267310
64SGK30.87588598
65RET0.87567468
66CSF1R0.87332250
67EPHA20.87170369
68EPHB20.86295416
69MYLK0.85309539
70RPS6KA20.85256475
71ERN10.85060059
72GSK3A0.84469273
73AKT30.83761443
74PAK60.82322733
75NLK0.82138200
76PHKG10.81797238
77PHKG20.81797238
78BCKDK0.81567733
79IRAK40.81161933
80MST40.80927550
81IRAK10.80718775
82PRKD10.79713900
83PRKD30.76456715
84ROCK20.75809589
85TRPM70.75333631
86PDK10.74016337
87KSR20.72890449
88MELK0.72693610
89FGFR10.71440801
90ROCK10.71329326
91PTK2B0.69687290
92MAPK70.69238513
93MAPK120.68795608
94LATS20.67129233
95HCK0.66886003
96PDPK10.66714705
97JAK20.65021683
98FGFR30.63928764
99PRKCH0.62580325
100SIK20.61983555
101TYRO30.60565625
102RPS6KC10.60146451
103RPS6KL10.60146451
104JAK30.59114629
105MTOR0.59069236
106STK30.58997199
107INSRR0.58456267
108MAPK110.58302139
109CDK60.57186063
110CDC42BPA0.56826841
111ERBB20.56336091
112NEK10.55964923
113STK100.55284215
114BTK0.54349394
115CAMK40.54180373
116IRAK30.53471720
117FRK0.52560276
118SGK10.52352275
119PAK20.51633504
120SGK20.51321322
121PRKD20.51035397
122JAK10.51015468
123ICK0.50389686
124MARK20.49824640
125PRKAA20.49815650
126MATK0.49497672
127MAP3K90.48971432
128PINK10.48720946
129PIK3CA0.47394172
130PRKAA10.46425537
131DYRK1B0.45552202
132HIPK20.43909041
133DAPK20.43499557
134RPS6KA60.42592585
135PKN10.41395602
136PRKCE0.37972157
137STK240.36986641
138SRC0.36068742
139NEK90.35158928
140MAP3K30.34361453
141INSR0.34147963
142CAMK2D0.33139821
143LIMK10.32651379
144FYN0.32076981
145ILK0.31047958

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.89883596
2Butanoate metabolism_Homo sapiens_hsa006502.18227417
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16069671
4Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.11418064
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87494404
6Propanoate metabolism_Homo sapiens_hsa006401.85750218
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82934802
8Cyanoamino acid metabolism_Homo sapiens_hsa004601.81742556
9Complement and coagulation cascades_Homo sapiens_hsa046101.79129333
10Staphylococcus aureus infection_Homo sapiens_hsa051501.73296064
11Mineral absorption_Homo sapiens_hsa049781.70554227
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67220965
13Osteoclast differentiation_Homo sapiens_hsa043801.62669176
14Acute myeloid leukemia_Homo sapiens_hsa052211.59724475
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59699048
16ECM-receptor interaction_Homo sapiens_hsa045121.59145386
17Notch signaling pathway_Homo sapiens_hsa043301.57188939
18Chronic myeloid leukemia_Homo sapiens_hsa052201.55312982
19Fatty acid degradation_Homo sapiens_hsa000711.53549194
20Non-small cell lung cancer_Homo sapiens_hsa052231.51158939
21Collecting duct acid secretion_Homo sapiens_hsa049661.50835038
22B cell receptor signaling pathway_Homo sapiens_hsa046621.49877618
23Bile secretion_Homo sapiens_hsa049761.49625409
24Protein digestion and absorption_Homo sapiens_hsa049741.47635946
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43279940
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43211013
27Nitrogen metabolism_Homo sapiens_hsa009101.41553685
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38855794
29Fatty acid metabolism_Homo sapiens_hsa012121.34846472
30Leishmaniasis_Homo sapiens_hsa051401.33365367
31Pyruvate metabolism_Homo sapiens_hsa006201.26969043
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24980955
33Platelet activation_Homo sapiens_hsa046111.24510756
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23552155
35VEGF signaling pathway_Homo sapiens_hsa043701.22996469
36Lysosome_Homo sapiens_hsa041421.22591005
37Gastric acid secretion_Homo sapiens_hsa049711.20949973
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20868821
39Thyroid cancer_Homo sapiens_hsa052161.20627934
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18129606
41Focal adhesion_Homo sapiens_hsa045101.17304772
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16401719
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15297362
44Peroxisome_Homo sapiens_hsa041461.14311794
45Toxoplasmosis_Homo sapiens_hsa051451.13914723
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13610947
47Lysine degradation_Homo sapiens_hsa003101.13579506
48Dilated cardiomyopathy_Homo sapiens_hsa054141.12448553
49Tryptophan metabolism_Homo sapiens_hsa003801.09511625
50Vitamin digestion and absorption_Homo sapiens_hsa049771.09199433
51mTOR signaling pathway_Homo sapiens_hsa041501.08747491
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07836303
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06514223
54GnRH signaling pathway_Homo sapiens_hsa049121.02624012
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.01863436
56Tight junction_Homo sapiens_hsa045301.00848676
57PPAR signaling pathway_Homo sapiens_hsa033201.00214321
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99806239
59Insulin signaling pathway_Homo sapiens_hsa049100.99507875
60Prostate cancer_Homo sapiens_hsa052150.98483907
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98381050
62Sulfur metabolism_Homo sapiens_hsa009200.98308051
63Hepatitis C_Homo sapiens_hsa051600.95910085
64Adherens junction_Homo sapiens_hsa045200.94705956
65ErbB signaling pathway_Homo sapiens_hsa040120.94650714
66Pertussis_Homo sapiens_hsa051330.94576376
67Malaria_Homo sapiens_hsa051440.94551816
68Tuberculosis_Homo sapiens_hsa051520.94045218
69Thyroid hormone synthesis_Homo sapiens_hsa049180.93570522
70Prolactin signaling pathway_Homo sapiens_hsa049170.91937499
71TNF signaling pathway_Homo sapiens_hsa046680.91400207
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91126259
73beta-Alanine metabolism_Homo sapiens_hsa004100.90417401
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.88063464
75FoxO signaling pathway_Homo sapiens_hsa040680.87797881
76T cell receptor signaling pathway_Homo sapiens_hsa046600.86549080
77Chemokine signaling pathway_Homo sapiens_hsa040620.85214509
78Influenza A_Homo sapiens_hsa051640.84646369
79MicroRNAs in cancer_Homo sapiens_hsa052060.84343827
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83835956
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83298588
82Colorectal cancer_Homo sapiens_hsa052100.82871465
83Hepatitis B_Homo sapiens_hsa051610.80955807
84Amoebiasis_Homo sapiens_hsa051460.80652927
85HIF-1 signaling pathway_Homo sapiens_hsa040660.80275464
86Prion diseases_Homo sapiens_hsa050200.79591690
87Proteoglycans in cancer_Homo sapiens_hsa052050.79220412
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78854944
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78222777
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.77995813
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77922441
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76712680
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.76590045
94Estrogen signaling pathway_Homo sapiens_hsa049150.74985680
95Dorso-ventral axis formation_Homo sapiens_hsa043200.74742681
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73372704
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.71800094
98Type II diabetes mellitus_Homo sapiens_hsa049300.71026816
99Arginine and proline metabolism_Homo sapiens_hsa003300.70600145
100Salivary secretion_Homo sapiens_hsa049700.70267807
101Phototransduction_Homo sapiens_hsa047440.70242997
102Hippo signaling pathway_Homo sapiens_hsa043900.70017987
103Measles_Homo sapiens_hsa051620.68436989
104Insulin resistance_Homo sapiens_hsa049310.67497211
105Apoptosis_Homo sapiens_hsa042100.67385124
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67356142
107Synaptic vesicle cycle_Homo sapiens_hsa047210.66435314
108Histidine metabolism_Homo sapiens_hsa003400.66270191
109Pathways in cancer_Homo sapiens_hsa052000.66263024
110Carbon metabolism_Homo sapiens_hsa012000.65526247
111Glycerolipid metabolism_Homo sapiens_hsa005610.65224323
112Glutathione metabolism_Homo sapiens_hsa004800.64702394
113Other glycan degradation_Homo sapiens_hsa005110.64694315
114Vibrio cholerae infection_Homo sapiens_hsa051100.63433435
115Fatty acid elongation_Homo sapiens_hsa000620.63123220
116Arginine biosynthesis_Homo sapiens_hsa002200.63022460
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.62397293
118Renal cell carcinoma_Homo sapiens_hsa052110.62071203
119Long-term potentiation_Homo sapiens_hsa047200.61581073
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.61518197
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.61355001
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60599405
123Renin secretion_Homo sapiens_hsa049240.60037932
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59664749
125Small cell lung cancer_Homo sapiens_hsa052220.57577681
126Choline metabolism in cancer_Homo sapiens_hsa052310.57191603
127Starch and sucrose metabolism_Homo sapiens_hsa005000.56996801
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56663766
129Phagosome_Homo sapiens_hsa041450.56204247
130MAPK signaling pathway_Homo sapiens_hsa040100.55781902
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55561243
132Bladder cancer_Homo sapiens_hsa052190.53798040
133Axon guidance_Homo sapiens_hsa043600.53769284
134Inositol phosphate metabolism_Homo sapiens_hsa005620.53519405
135Hematopoietic cell lineage_Homo sapiens_hsa046400.53265075
136African trypanosomiasis_Homo sapiens_hsa051430.52681452
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52558509
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52378377
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52356992
140Rap1 signaling pathway_Homo sapiens_hsa040150.51679766
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50970319
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50344691
143Legionellosis_Homo sapiens_hsa051340.49575760
144ABC transporters_Homo sapiens_hsa020100.49405750
145AMPK signaling pathway_Homo sapiens_hsa041520.49334285
146Endocytosis_Homo sapiens_hsa041440.48338844
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47088668
148Sphingolipid metabolism_Homo sapiens_hsa006000.46897943
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46791894
150Endometrial cancer_Homo sapiens_hsa052130.46538036
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44582656
152Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42523058
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.41625230
154Pancreatic cancer_Homo sapiens_hsa052120.41498923
155Renin-angiotensin system_Homo sapiens_hsa046140.40844672
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40220067
157Glioma_Homo sapiens_hsa052140.40139965
158Ovarian steroidogenesis_Homo sapiens_hsa049130.40139365
159Pancreatic secretion_Homo sapiens_hsa049720.39847810
160Vascular smooth muscle contraction_Homo sapiens_hsa042700.39474176

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