ATP11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.38411381
2negative regulation of cell killing (GO:0031342)6.38411381
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.48395002
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.48395002
5positive regulation of gamma-delta T cell activation (GO:0046645)4.88968091
6antigen processing and presentation of endogenous antigen (GO:0019883)4.61769794
7negative T cell selection (GO:0043383)4.24054137
8negative thymic T cell selection (GO:0045060)4.19356598
9response to interleukin-15 (GO:0070672)3.96108130
10mitotic sister chromatid cohesion (GO:0007064)3.94920212
11regulation of gamma-delta T cell differentiation (GO:0045586)3.90745641
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79622470
13histone H3-K4 trimethylation (GO:0080182)3.69061494
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67080765
15interferon-gamma production (GO:0032609)3.65974319
16nuclear pore complex assembly (GO:0051292)3.62411531
17detection of other organism (GO:0098543)3.61388519
18regulation of RNA export from nucleus (GO:0046831)3.60779872
19positive thymic T cell selection (GO:0045059)3.59057716
20detection of molecule of bacterial origin (GO:0032490)3.57636936
21cellular extravasation (GO:0045123)3.56562556
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55811202
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.55811202
24modulation by symbiont of host immune response (GO:0052553)3.55811202
25positive regulation by symbiont of host defense response (GO:0052509)3.55811202
26modulation by symbiont of host defense response (GO:0052031)3.55811202
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55811202
28negative regulation of erythrocyte differentiation (GO:0045647)3.50457166
29regulation of gamma-delta T cell activation (GO:0046643)3.48372974
30cellular response to interleukin-15 (GO:0071350)3.46193938
31positive T cell selection (GO:0043368)3.45302356
32regulation of nucleobase-containing compound transport (GO:0032239)3.38649429
33phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.36458121
34negative regulation of T cell mediated immunity (GO:0002710)3.35365670
35T cell homeostasis (GO:0043029)3.33859967
36thymic T cell selection (GO:0045061)3.32981886
37T cell selection (GO:0045058)3.31497575
38detection of external biotic stimulus (GO:0098581)3.30843789
39hypotonic response (GO:0006971)3.30632170
40regulation of DNA endoreduplication (GO:0032875)3.28841378
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27806358
42detection of bacterium (GO:0016045)3.26925106
43embryonic process involved in female pregnancy (GO:0060136)3.24553962
44cytoplasmic mRNA processing body assembly (GO:0033962)3.20514529
45regulation of B cell receptor signaling pathway (GO:0050855)3.17123007
46response to peptidoglycan (GO:0032494)3.16854856
47positive regulation of histone deacetylation (GO:0031065)3.16813845
48nuclear pore organization (GO:0006999)3.10908609
49antigen processing and presentation via MHC class Ib (GO:0002475)3.10631840
50macrophage activation involved in immune response (GO:0002281)3.08138414
51definitive hemopoiesis (GO:0060216)3.07861598
52leukocyte aggregation (GO:0070486)3.07319674
53mast cell activation (GO:0045576)3.05939627
54mast cell activation involved in immune response (GO:0002279)3.05380084
55mast cell degranulation (GO:0043303)3.05380084
56regulation of necroptotic process (GO:0060544)3.04332420
57positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03909645
58megakaryocyte development (GO:0035855)3.02490167
59neutrophil activation involved in immune response (GO:0002283)2.99944269
60negative regulation of phagocytosis (GO:0050765)2.97679130
61iron ion import (GO:0097286)2.93264958
62B cell receptor signaling pathway (GO:0050853)2.92779885
63response to muramyl dipeptide (GO:0032495)2.92536395
64activated T cell proliferation (GO:0050798)2.90648303
65retrograde transport, vesicle recycling within Golgi (GO:0000301)2.90180330
66T cell migration (GO:0072678)2.89489021
67cellular response to ethanol (GO:0071361)2.89336874
68positive regulation of mRNA catabolic process (GO:0061014)2.88852885
69response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88087526
70response to host (GO:0075136)2.88087526
71response to host defenses (GO:0052200)2.88087526
72peptidyl-lysine trimethylation (GO:0018023)2.86908140
73negative regulation of T-helper cell differentiation (GO:0045623)2.85048068
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85048068
75detection of biotic stimulus (GO:0009595)2.83848571
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.81816233
77response to host immune response (GO:0052572)2.81816233
78mRNA splice site selection (GO:0006376)2.79860790
79protein targeting to Golgi (GO:0000042)2.79805868
80germinal center formation (GO:0002467)2.79287442
81histone H3-K36 demethylation (GO:0070544)2.78644920
82germ cell migration (GO:0008354)2.78267385
83tolerance induction (GO:0002507)2.77707328
84positive regulation of B cell differentiation (GO:0045579)2.76874399
85regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76067787
86positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76067787
87regulation of interleukin-12 biosynthetic process (GO:0045075)2.75724501
88glucocorticoid receptor signaling pathway (GO:0042921)2.75283417
89lymphocyte homeostasis (GO:0002260)2.75187455
90histone H3-K4 methylation (GO:0051568)2.73813717
91T cell receptor signaling pathway (GO:0050852)2.71973758
92regulation of mRNA catabolic process (GO:0061013)2.71896474
93regulation of interferon-beta biosynthetic process (GO:0045357)2.71539417
94negative regulation of histone methylation (GO:0031061)2.71384094
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71348368
96histone H3-K9 demethylation (GO:0033169)2.69485725
97alpha-beta T cell activation (GO:0046631)2.68179962
98T cell costimulation (GO:0031295)2.68123164
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.66301747
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65906770
101regulation of natural killer cell mediated immunity (GO:0002715)2.65745885
102regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65745885
103alternative mRNA splicing, via spliceosome (GO:0000380)2.64385906
104negative regulation of interleukin-12 production (GO:0032695)2.63698678
105necroptotic process (GO:0070266)2.62911932
106hepatocyte apoptotic process (GO:0097284)2.61151655
107lymphocyte costimulation (GO:0031294)2.61029156
108DNA unwinding involved in DNA replication (GO:0006268)2.60482569
109regulation of alpha-beta T cell proliferation (GO:0046640)2.60023693
110antigen receptor-mediated signaling pathway (GO:0050851)2.59296805
111NIK/NF-kappaB signaling (GO:0038061)2.58478393
112positive regulation of granulocyte differentiation (GO:0030854)2.58455094
113establishment of protein localization to Golgi (GO:0072600)2.56168544
114B cell homeostasis (GO:0001782)2.52999354
115regulation of isotype switching to IgG isotypes (GO:0048302)2.52202154
116histone mRNA catabolic process (GO:0071044)2.51624445
117regulation of histone H3-K27 methylation (GO:0061085)2.51514442
118natural killer cell differentiation (GO:0001779)2.50577812
119T cell differentiation (GO:0030217)2.50174930
120regulation of T cell receptor signaling pathway (GO:0050856)2.49904450
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.49889222
122regulation of clathrin-mediated endocytosis (GO:2000369)2.49124624
123pre-miRNA processing (GO:0031054)2.49061247
124pore complex assembly (GO:0046931)2.48847737
125regulation of B cell differentiation (GO:0045577)2.48695088
126alpha-beta T cell differentiation (GO:0046632)2.48625543
127corticosteroid receptor signaling pathway (GO:0031958)2.48372560
128regulation of histone H3-K9 methylation (GO:0051570)2.47942682
129embryonic hemopoiesis (GO:0035162)2.47917176
130cellular potassium ion homeostasis (GO:0030007)2.47248636
131* phospholipid translocation (GO:0045332)2.46886082
132* lipid translocation (GO:0034204)2.46886082
133JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46483384
134peptidyl-threonine phosphorylation (GO:0018107)2.46386048
135regulation of histone H3-K4 methylation (GO:0051569)2.46128572
136CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.45270151
137T-helper cell differentiation (GO:0042093)2.45270151
138response to laminar fluid shear stress (GO:0034616)2.44522873
139T cell proliferation (GO:0042098)2.42812805
140necrotic cell death (GO:0070265)2.42745232
141natural killer cell activation (GO:0030101)2.42398094
142regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41920123
143lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41528664
144regulation of granulocyte differentiation (GO:0030852)2.41159573
145dosage compensation (GO:0007549)2.39767451
146histone lysine demethylation (GO:0070076)2.38196883
147programmed necrotic cell death (GO:0097300)2.38023336
148macrophage activation (GO:0042116)2.35854196
149positive regulation of alpha-beta T cell proliferation (GO:0046641)2.35262539
150myeloid cell activation involved in immune response (GO:0002275)2.33039438
151negative regulation of leukocyte mediated immunity (GO:0002704)2.31406059
152histone demethylation (GO:0016577)2.31033886
153regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.30484300
154monoubiquitinated protein deubiquitination (GO:0035520)2.30044627
155negative regulation of DNA repair (GO:0045738)2.28992962
156negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.27648953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.18647032
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.69563442
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.18106655
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.57541531
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.22981680
6RUNX_20019798_ChIP-Seq_JUKART_Human3.14527379
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.07046664
8MYC_22102868_ChIP-Seq_BL_Human3.02959833
9SCL_19346495_ChIP-Seq_HPC-7_Human3.00741890
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.95147384
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73603223
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.72344413
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71797217
14GATA1_22025678_ChIP-Seq_K562_Human2.68846361
15MYB_26560356_Chip-Seq_TH2_Human2.67510206
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.64626784
17* TCF7_22412390_ChIP-Seq_EML_Mouse2.41909023
18MYB_26560356_Chip-Seq_TH1_Human2.40126960
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.31763765
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29327573
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27658784
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23848687
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13467284
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08533576
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08130168
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.02369932
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00382354
28* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00228127
29MAF_26560356_Chip-Seq_TH1_Human1.96828840
30* UTX_26944678_Chip-Seq_JUKART_Human1.93895727
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.92306753
32VDR_21846776_ChIP-Seq_THP-1_Human1.86979238
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.85620473
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80438582
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76014164
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.73084297
37* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.72428817
38KDM2B_26808549_Chip-Seq_DND41_Human1.68880408
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67976079
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.67941091
41SPI1_23127762_ChIP-Seq_K562_Human1.67072533
42GATA3_27048872_Chip-Seq_THYMUS_Human1.64416186
43VDR_24763502_ChIP-Seq_THP-1_Human1.64133996
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59154486
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.54874225
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51250804
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.50634313
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47505565
49SPI1_23547873_ChIP-Seq_NB4_Human1.46722865
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45184654
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45013692
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45013692
53TP53_16413492_ChIP-PET_HCT116_Human1.44888148
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44870835
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40795354
56* KDM2B_26808549_Chip-Seq_JURKAT_Human1.39300158
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37625894
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36698548
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36458708
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34483733
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34474749
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33654398
63PU_27001747_Chip-Seq_BMDM_Mouse1.31030286
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.26395563
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24261969
66* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23428299
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20744874
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16944336
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16523590
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15918119
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15820734
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14240101
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13453374
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.13386092
75CIITA_25753668_ChIP-Seq_RAJI_Human1.12934497
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.12897428
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12607021
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11366305
79* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11300689
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10414306
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09440038
82* MAF_26560356_Chip-Seq_TH2_Human1.08767305
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08279248
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.06928260
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05844593
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05701488
87GATA3_26560356_Chip-Seq_TH2_Human1.04921097
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.02664817
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01019738
90DROSHA_22980978_ChIP-Seq_HELA_Human1.00914931
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97082206
92* GATA2_19941826_ChIP-Seq_K562_Human0.95758228
93RARB_27405468_Chip-Seq_BRAIN_Mouse0.94412242
94ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91910471
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91287803
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91237368
97CLOCK_20551151_ChIP-Seq_293T_Human0.90746942
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89651567
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.89329802
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89223024
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88911748
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88261327
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88130891
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87853030
105BRD4_25478319_ChIP-Seq_HGPS_Human0.87464631
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85189978
107STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84893668
108NCOR1_26117541_ChIP-Seq_K562_Human0.84748923
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84601873
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83371422
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82524707
112GATA1_19941826_ChIP-Seq_K562_Human0.82368740
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81942286
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81256744
115TP63_23658742_ChIP-Seq_EP156T_Human0.81249615
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80865091
117AR_21572438_ChIP-Seq_LNCaP_Human0.80631478
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80367065
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80306800
120* CHD1_26751641_Chip-Seq_LNCaP_Human0.78539502
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77084507
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76789353
123VDR_24787735_ChIP-Seq_THP-1_Human0.76477787
124* SMRT_27268052_Chip-Seq_Bcells_Human0.74077976
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.73814050
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.73513048
127GATA3_26560356_Chip-Seq_TH1_Human0.73299897
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70816199
129TAF15_26573619_Chip-Seq_HEK293_Human0.70583550
130* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.69959096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.44125415
2MP0002396_abnormal_hematopoietic_system3.29765337
3MP0003300_gastrointestinal_ulcer3.22391409
4MP0003303_peritoneal_inflammation3.00031657
5MP0005671_abnormal_response_to2.97653348
6MP0003763_abnormal_thymus_physiology2.82396927
7MP0010234_abnormal_vibrissa_follicle2.63570194
8MP0003724_increased_susceptibility_to2.52182497
9MP0002166_altered_tumor_susceptibility2.45368011
10MP0001835_abnormal_antigen_presentation2.25797778
11MP0005174_abnormal_tail_pigmentation2.21298780
12MP0001800_abnormal_humoral_immune2.18695841
13MP0002398_abnormal_bone_marrow2.16428394
14MP0010352_gastrointestinal_tract_polyps2.15691640
15MP0004808_abnormal_hematopoietic_stem2.13557823
16MP0000685_abnormal_immune_system2.13534925
17MP0003787_abnormal_imprinting2.10142069
18MP0000465_gastrointestinal_hemorrhage2.09651313
19MP0003866_abnormal_defecation2.07522804
20MP0002877_abnormal_melanocyte_morpholog2.06340027
21MP0002006_tumorigenesis2.03638999
22MP0001873_stomach_inflammation2.00552480
23MP0002420_abnormal_adaptive_immunity1.99608101
24MP0005451_abnormal_body_composition1.98609611
25MP0001819_abnormal_immune_cell1.97459443
26MP0003191_abnormal_cellular_cholesterol1.92447117
27MP0000703_abnormal_thymus_morphology1.87611198
28MP0010155_abnormal_intestine_physiology1.84636566
29MP0002723_abnormal_immune_serum1.82629280
30MP0004859_abnormal_synaptic_plasticity1.82519914
31MP0003183_abnormal_peptide_metabolism1.82023466
32MP0002452_abnormal_antigen_presenting1.81521101
33MP0001790_abnormal_immune_system1.79509834
34MP0005387_immune_system_phenotype1.79509834
35MP0008961_abnormal_basal_metabolism1.78751380
36MP0003705_abnormal_hypodermis_morpholog1.76353241
37MP0005464_abnormal_platelet_physiology1.76002410
38MP0008057_abnormal_DNA_replication1.75275247
39MP0005275_abnormal_skin_tensile1.74973552
40MP0003436_decreased_susceptibility_to1.74870084
41MP0005000_abnormal_immune_tolerance1.73479022
42MP0000716_abnormal_immune_system1.73356593
43MP0003828_pulmonary_edema1.71814206
44MP0003656_abnormal_erythrocyte_physiolo1.70772321
45MP0001545_abnormal_hematopoietic_system1.68696727
46MP0005397_hematopoietic_system_phenotyp1.68696727
47MP0010307_abnormal_tumor_latency1.67858526
48MP0005025_abnormal_response_to1.64930004
49MP0002722_abnormal_immune_system1.62066412
50MP0004381_abnormal_hair_follicle1.61788467
51MP0003566_abnormal_cell_adhesion1.59489414
52MP0009785_altered_susceptibility_to1.57191959
53MP0003091_abnormal_cell_migration1.56484341
54MP0002796_impaired_skin_barrier1.53104067
55MP0003453_abnormal_keratinocyte_physiol1.51191166
56MP0000689_abnormal_spleen_morphology1.50270615
57MP0008260_abnormal_autophagy1.50047986
58MP0002419_abnormal_innate_immunity1.49977892
59MP0009278_abnormal_bone_marrow1.47039537
60MP0005076_abnormal_cell_differentiation1.46245757
61MP0005310_abnormal_salivary_gland1.41565626
62MP0002429_abnormal_blood_cell1.40829602
63MP0005423_abnormal_somatic_nervous1.39343785
64MP0008438_abnormal_cutaneous_collagen1.38227110
65MP0000490_abnormal_crypts_of1.36655609
66MP0005409_darkened_coat_color1.33029958
67MP0004947_skin_inflammation1.32366594
68MP0009780_abnormal_chondrocyte_physiolo1.26793374
69MP0004185_abnormal_adipocyte_glucose1.26518807
70MP0002405_respiratory_system_inflammati1.22838338
71MP0004883_abnormal_blood_vessel1.22148509
72MP0002095_abnormal_skin_pigmentation1.20766471
73MP0008877_abnormal_DNA_methylation1.14456074
74MP0005164_abnormal_response_to1.14121573
75MP0002138_abnormal_hepatobiliary_system1.14086562
76MP0002009_preneoplasia1.13745733
77MP0010094_abnormal_chromosome_stability1.13346438
78MP0002060_abnormal_skin_morphology1.11595779
79MP0005551_abnormal_eye_electrophysiolog1.10924847
80MP0001845_abnormal_inflammatory_respons1.10849402
81MP0002998_abnormal_bone_remodeling1.09764516
82MP0003635_abnormal_synaptic_transmissio1.08214905
83MP0001663_abnormal_digestive_system1.05878686
84MP0005075_abnormal_melanosome_morpholog1.05422648
85MP0004510_myositis1.05370967
86MP0001216_abnormal_epidermal_layer1.04896593
87MP0001986_abnormal_taste_sensitivity1.03093169
88MP0003221_abnormal_cardiomyocyte_apopto1.01433341
89MP0008569_lethality_at_weaning0.99007257
90MP0005023_abnormal_wound_healing0.97315707
91MP0001853_heart_inflammation0.96580899
92MP0003868_abnormal_feces_composition0.96011811
93MP0003172_abnormal_lysosome_physiology0.95590030
94MP0002148_abnormal_hypersensitivity_rea0.94111867
95MP0002928_abnormal_bile_duct0.93859793
96MP0005666_abnormal_adipose_tissue0.93111537
97MP0001851_eye_inflammation0.90656466
98MP0004264_abnormal_extraembryonic_tissu0.89936445
99MP0002019_abnormal_tumor_incidence0.88162570
100MP0005621_abnormal_cell_physiology0.86747379
101MP0008004_abnormal_stomach_pH0.86449646
102MP0002132_abnormal_respiratory_system0.85207085
103MP0003111_abnormal_nucleus_morphology0.84867962
104MP0009745_abnormal_behavioral_response0.84530553
105MP0000015_abnormal_ear_pigmentation0.83830209
106MP0006072_abnormal_retinal_apoptosis0.82973418
107MP0005501_abnormal_skin_physiology0.81652985
108MP0003448_altered_tumor_morphology0.81292048
109MP0001501_abnormal_sleep_pattern0.80724970
110MP0000858_altered_metastatic_potential0.78713739
111MP0001188_hyperpigmentation0.78635783
112MP0008469_abnormal_protein_level0.78419328
113MP0004885_abnormal_endolymph0.77525980
114MP0001191_abnormal_skin_condition0.77190230
115MP0001958_emphysema0.76225998
116MP0002063_abnormal_learning/memory/cond0.74659323
117MP0003045_fibrosis0.73986202
118MP0009931_abnormal_skin_appearance0.73901928
119MP0009333_abnormal_splenocyte_physiolog0.73880770
120MP0009115_abnormal_fat_cell0.71905719
121MP0004147_increased_porphyrin_level0.71543993
122MP0000383_abnormal_hair_follicle0.71282008
123MP0000249_abnormal_blood_vessel0.71279147
124MP0006082_CNS_inflammation0.70996402
125MP0002086_abnormal_extraembryonic_tissu0.68821265
126MP0010678_abnormal_skin_adnexa0.67610418
127MP0002064_seizures0.66323455
128MP0009765_abnormal_xenobiotic_induced0.65913470
129MP0001915_intracranial_hemorrhage0.64466385
130MP0003077_abnormal_cell_cycle0.64170690
131MP0004270_analgesia0.62543142
132MP0001533_abnormal_skeleton_physiology0.62279736
133MP0000477_abnormal_intestine_morphology0.62060273
134MP0000604_amyloidosis0.62024336
135MP0003943_abnormal_hepatobiliary_system0.60332045
136MP0005253_abnormal_eye_physiology0.60051368
137MP0006054_spinal_hemorrhage0.59025461

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.44795226
2Papilledema (HP:0001085)4.19394649
3Chronic otitis media (HP:0000389)4.00256563
4T lymphocytopenia (HP:0005403)3.76054619
5Recurrent viral infections (HP:0004429)3.55822718
6IgM deficiency (HP:0002850)3.55387360
7Abnormality of T cell number (HP:0011839)3.51640175
8Abnormality of the fingertips (HP:0001211)3.48698148
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.39554686
10Recurrent fungal infections (HP:0002841)3.33765303
11Subacute progressive viral hepatitis (HP:0006572)3.14860069
12Macroorchidism (HP:0000053)2.99417553
13Gastrointestinal infarctions (HP:0005244)2.86064434
14Abnormality of T cells (HP:0002843)2.85122339
15Autoimmune hemolytic anemia (HP:0001890)2.83495280
16Recurrent bronchitis (HP:0002837)2.80182217
17Prominent nose (HP:0000448)2.73344240
18Chest pain (HP:0100749)2.63122659
19Acute myeloid leukemia (HP:0004808)2.60885174
20Prolonged bleeding time (HP:0003010)2.60322527
21Gingivitis (HP:0000230)2.60064084
22Abnormality of macrophages (HP:0004311)2.57522201
23Thyroiditis (HP:0100646)2.57275589
24Colitis (HP:0002583)2.53242906
25Nasal polyposis (HP:0100582)2.52961651
26Recurrent cutaneous fungal infections (HP:0011370)2.50954513
27Chronic mucocutaneous candidiasis (HP:0002728)2.50954513
28Heterotopia (HP:0002282)2.48778381
29Eczematoid dermatitis (HP:0000976)2.46124588
30Osteolytic defects of the hand bones (HP:0009699)2.44073628
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.44073628
32Abnormality of binocular vision (HP:0011514)2.43508530
33Diplopia (HP:0000651)2.43508530
34Thick nail (HP:0001805)2.43269990
35Panhypogammaglobulinemia (HP:0003139)2.39459549
36Viral hepatitis (HP:0006562)2.37800315
37Congenital stationary night blindness (HP:0007642)2.37293820
38Orchitis (HP:0100796)2.36733129
39Absent frontal sinuses (HP:0002688)2.34189274
40Thrombocytosis (HP:0001894)2.33651383
41Recurrent abscess formation (HP:0002722)2.33340525
42Lymphopenia (HP:0001888)2.29382740
43Meningitis (HP:0001287)2.29221568
44Abnormality of oral frenula (HP:0000190)2.28307140
45Inappropriate behavior (HP:0000719)2.27613861
46Pustule (HP:0200039)2.27370278
47Keratoconjunctivitis sicca (HP:0001097)2.26810328
48Optic neuritis (HP:0100653)2.25557000
49Retrobulbar optic neuritis (HP:0100654)2.25557000
50Mediastinal lymphadenopathy (HP:0100721)2.24242215
51Osteomyelitis (HP:0002754)2.21605142
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.20350542
53IgG deficiency (HP:0004315)2.20043224
54Inflammation of the large intestine (HP:0002037)2.18686713
55Granulocytopenia (HP:0001913)2.18390330
56Peritonitis (HP:0002586)2.17682531
57IgA deficiency (HP:0002720)2.17497561
58Gastrointestinal inflammation (HP:0004386)2.17438225
59Hypoplasia of the thymus (HP:0000778)2.17223503
60Papillary thyroid carcinoma (HP:0002895)2.17126041
61Abnormality of nail color (HP:0100643)2.16514271
62Hemiplegia (HP:0002301)2.16276571
63Spinal cord lesions (HP:0100561)2.14999737
64Syringomyelia (HP:0003396)2.14999737
65Protruding tongue (HP:0010808)2.14198005
66Abnormality of B cell number (HP:0010975)2.13775954
67B lymphocytopenia (HP:0010976)2.13775954
68Bony spicule pigmentary retinopathy (HP:0007737)2.11302316
69Curly hair (HP:0002212)2.10318780
70Flat acetabular roof (HP:0003180)2.09664931
71Elevated erythrocyte sedimentation rate (HP:0003565)2.09312219
72Myositis (HP:0100614)2.08901610
73Impaired smooth pursuit (HP:0007772)2.07438660
74Aortic aneurysm (HP:0004942)2.06624346
75Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06066556
76Cellulitis (HP:0100658)2.06049754
77Dilatation of the ascending aorta (HP:0005111)2.05423906
78Recurrent gram-negative bacterial infections (HP:0005420)2.05026819
79Periodontitis (HP:0000704)2.04955380
80Abnormality of T cell physiology (HP:0011840)2.04798592
81Stomatitis (HP:0010280)2.04064846
82Ankyloglossia (HP:0010296)2.03610570
83Chronic diarrhea (HP:0002028)2.03401155
84Eosinophilia (HP:0001880)2.02376738
85Abnormality of the astrocytes (HP:0100707)2.02310558
86Astrocytoma (HP:0009592)2.02310558
87Chronic sinusitis (HP:0011109)2.01791700
88Increased IgE level (HP:0003212)2.01458480
89Interstitial pulmonary disease (HP:0006530)2.00864700
90Spondylolisthesis (HP:0003302)1.99704614
91Obstructive lung disease (HP:0006536)1.99645205
92Chronic obstructive pulmonary disease (HP:0006510)1.99645205
93Visual hallucinations (HP:0002367)1.98873305
94Urticaria (HP:0001025)1.98791968
95Arterial thrombosis (HP:0004420)1.98536344
96Coarse hair (HP:0002208)1.98066871
97Slow saccadic eye movements (HP:0000514)1.97893751
98Basal cell carcinoma (HP:0002671)1.97329874
99Keratoconjunctivitis (HP:0001096)1.96814551
100Abnormality of ocular smooth pursuit (HP:0000617)1.96667747
101Abnormal platelet volume (HP:0011876)1.96359025
102Epistaxis (HP:0000421)1.95759193
103Leukocytosis (HP:0001974)1.95524367
104Verrucae (HP:0200043)1.94630852
105Papilloma (HP:0012740)1.94630852
106Arterial tortuosity (HP:0005116)1.93347869
107Encephalitis (HP:0002383)1.92070122
108Hepatitis (HP:0012115)1.91959847
109Lymphoma (HP:0002665)1.91666088
110Abnormality of eosinophils (HP:0001879)1.90518290
111Fatigue (HP:0012378)1.89896257
112Generalized hypopigmentation of hair (HP:0011358)1.89332824
113Obsessive-compulsive behavior (HP:0000722)1.87465421
114High pitched voice (HP:0001620)1.87460885
115Abnormality of the nasal mucosa (HP:0000433)1.86719189
116Recurrent bacterial skin infections (HP:0005406)1.85500649
117Tented upper lip vermilion (HP:0010804)1.84416351
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82354334
119Truncal obesity (HP:0001956)1.82349831
120Hyperacusis (HP:0010780)1.82127268
121Gingival bleeding (HP:0000225)1.82046688
122Severe combined immunodeficiency (HP:0004430)1.81975201
123Amaurosis fugax (HP:0100576)1.81429975
124Skin ulcer (HP:0200042)1.81322706
125Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.79362719
126Abnormality of the peritoneum (HP:0002585)1.79186494
127Deep philtrum (HP:0002002)1.79084367
128Abnormal rod and cone electroretinograms (HP:0008323)1.78964199
129Neoplasm of the small intestine (HP:0100833)1.78886004
130Milia (HP:0001056)1.78006695
131Spontaneous hematomas (HP:0007420)1.77739864
132Cutis marmorata (HP:0000965)1.77564647
133Autoimmune thrombocytopenia (HP:0001973)1.77309154
134Abnormality of the thoracic spine (HP:0100711)1.76884896
135Aortic dissection (HP:0002647)1.75594309
136Fair hair (HP:0002286)1.74796356
137Vasculitis (HP:0002633)1.74446422
138Tapered finger (HP:0001182)1.74321126
139Dysmetric saccades (HP:0000641)1.73321490
140Pulmonary infiltrates (HP:0002113)1.73188932
141Biliary tract neoplasm (HP:0100574)1.73152258
142Recurrent skin infections (HP:0001581)1.72874171
143Truncal ataxia (HP:0002078)1.72519279
144Alopecia of scalp (HP:0002293)1.72011690
145Vascular tortuosity (HP:0004948)1.69004005
146Thickened calvaria (HP:0002684)1.68861400
147Right ventricular cardiomyopathy (HP:0011663)1.67989394
148Neonatal hypoglycemia (HP:0001998)1.67106808
149Erythema (HP:0010783)1.66954943
150Broad face (HP:0000283)1.66785509
151Polycythemia (HP:0001901)1.65741842
152Relative macrocephaly (HP:0004482)1.64982685
153Hemoptysis (HP:0002105)1.64778563
154Onycholysis (HP:0001806)1.63970865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.32751399
2MAP4K13.15609582
3EEF2K2.69737270
4PKN22.42536996
5TXK2.39168219
6GRK62.38659754
7ITK2.31361346
8CDK122.06813265
9FGFR32.05498697
10BLK2.03046765
11RIPK42.01024146
12JAK31.96839559
13MAP2K31.91730309
14STK101.91512192
15TAOK31.90374747
16SIK21.86754806
17STK31.84549689
18MAP3K101.81282397
19TRIB31.77385838
20ERN11.76846486
21CDC71.76492068
22MAP3K131.69439725
23MAP3K141.69000596
24BMPR21.62524709
25TYK21.62167213
26BRD41.61412065
27KIT1.60344058
28PIK3CG1.60335664
29JAK11.60309025
30ALK1.59607359
31BTK1.56210012
32FES1.55756094
33AKT31.52433998
34KSR21.51171611
35PTK61.51054352
36SCYL21.50202531
37TEC1.47353913
38MAP3K91.45849049
39NEK91.39379876
40NLK1.37566077
41STK241.36733152
42TRPM71.33611831
43FGFR41.28007154
44MAP3K71.25481059
45HCK1.21103861
46CAMK1G1.18051823
47MAP3K31.15959693
48FGFR21.14762737
49YES11.13374832
50LCK1.12676841
51MAP3K41.12234323
52TNK21.11404608
53IRAK41.10527148
54RET1.10216719
55IRAK11.09998693
56MAP3K11.09185705
57SYK1.09018915
58CDK61.08361144
59FRK1.08171413
60PNCK1.06448282
61NTRK31.06384794
62CSK1.05657706
63FLT31.04503656
64TNIK0.98549652
65NEK20.98313142
66MELK0.95501969
67SGK30.93770524
68CDK40.93110576
69SGK20.89523886
70IKBKE0.89375052
71PDGFRA0.88491633
72CAMKK20.88029696
73JAK20.86616038
74PRKCH0.86263482
75TGFBR20.86231089
76SIK30.85729173
77MAP3K120.85433719
78CDK90.85382316
79RIPK10.85284406
80EPHB10.83703109
81KSR10.83586051
82SMG10.82501301
83ZAP700.82136795
84PIM10.81474492
85PDK10.81019470
86PRKCQ0.80851733
87TBK10.80213789
88LATS10.78831211
89ICK0.76895628
90IRAK20.75682356
91MARK30.74930030
92CSF1R0.74599469
93FGFR10.74044125
94HIPK20.72872599
95MATK0.71606275
96TTN0.70947360
97WNK10.69158985
98FGR0.69072334
99CAMK1D0.67053079
100ATR0.66946012
101MST40.66833601
102IKBKB0.65999833
103LRRK20.65356586
104CSNK1A1L0.64676903
105CSNK1G20.63361995
106STK110.62456903
107IRAK30.60927259
108MAP3K60.60778893
109MAP2K40.59885775
110CLK10.59306014
111MAPK110.58837822
112PDGFRB0.58537382
113NTRK20.55535265
114RAF10.55333668
115NEK60.55316125
116NUAK10.54268198
117SIK10.53229466
118EIF2AK30.53109034
119TYRO30.52841369
120MAPK70.52379848
121ATM0.52306692
122MTOR0.52146087
123PDPK10.51759450
124PASK0.51131259
125CHEK10.50867320
126MAP3K20.50168885
127FYN0.49957147
128DAPK10.49934013
129CSNK1D0.49917031
130RPS6KB20.47195668
131MAP2K70.46774077
132LYN0.46285453
133MARK20.45901104
134CAMKK10.45411471
135RPS6KB10.45167018
136CDK50.43569347
137TAOK10.43252797
138STK40.41139358
139MAPK140.40800106
140SGK10.40615163

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.21212376
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.07619948
3T cell receptor signaling pathway_Homo sapiens_hsa046602.01735217
4Phototransduction_Homo sapiens_hsa047441.86585465
5B cell receptor signaling pathway_Homo sapiens_hsa046621.81944128
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59651081
7Dorso-ventral axis formation_Homo sapiens_hsa043201.55540910
8Long-term potentiation_Homo sapiens_hsa047201.53007250
9Acute myeloid leukemia_Homo sapiens_hsa052211.52230901
10Osteoclast differentiation_Homo sapiens_hsa043801.48931640
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47733253
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45776227
13Measles_Homo sapiens_hsa051621.44990214
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.43107241
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40672689
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38551824
17Non-small cell lung cancer_Homo sapiens_hsa052231.38512883
18Leishmaniasis_Homo sapiens_hsa051401.37785576
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37150754
20Antigen processing and presentation_Homo sapiens_hsa046121.35174527
21Chemokine signaling pathway_Homo sapiens_hsa040621.34643293
22Chronic myeloid leukemia_Homo sapiens_hsa052201.30732745
23Thyroid cancer_Homo sapiens_hsa052161.25070203
24Endometrial cancer_Homo sapiens_hsa052131.22299096
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.20152619
26Malaria_Homo sapiens_hsa051441.18976768
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18295475
28Toxoplasmosis_Homo sapiens_hsa051451.18149066
29Colorectal cancer_Homo sapiens_hsa052101.17280412
30Inositol phosphate metabolism_Homo sapiens_hsa005621.17087927
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.16742308
32Platelet activation_Homo sapiens_hsa046111.13834113
33Type II diabetes mellitus_Homo sapiens_hsa049301.13698873
34Hepatitis B_Homo sapiens_hsa051611.12888206
35Pancreatic cancer_Homo sapiens_hsa052121.11799063
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.11140529
37Staphylococcus aureus infection_Homo sapiens_hsa051501.10118897
38Hematopoietic cell lineage_Homo sapiens_hsa046401.08815921
39Glioma_Homo sapiens_hsa052141.05681530
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05455846
41Herpes simplex infection_Homo sapiens_hsa051681.04930413
42Nicotine addiction_Homo sapiens_hsa050331.03005062
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02988962
44Legionellosis_Homo sapiens_hsa051341.00134601
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.98892614
46Autoimmune thyroid disease_Homo sapiens_hsa053200.98827604
47Prolactin signaling pathway_Homo sapiens_hsa049170.98772870
48VEGF signaling pathway_Homo sapiens_hsa043700.98626519
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98177212
50TNF signaling pathway_Homo sapiens_hsa046680.97651988
51Choline metabolism in cancer_Homo sapiens_hsa052310.96973808
52Morphine addiction_Homo sapiens_hsa050320.96905018
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96787826
54mTOR signaling pathway_Homo sapiens_hsa041500.95938742
55Amoebiasis_Homo sapiens_hsa051460.95526443
56Glutamatergic synapse_Homo sapiens_hsa047240.95034036
57ErbB signaling pathway_Homo sapiens_hsa040120.93153696
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92593631
59Circadian entrainment_Homo sapiens_hsa047130.92429003
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92291258
61Salivary secretion_Homo sapiens_hsa049700.90789979
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90775065
63MicroRNAs in cancer_Homo sapiens_hsa052060.90445333
64Focal adhesion_Homo sapiens_hsa045100.89382414
65Influenza A_Homo sapiens_hsa051640.88515120
66Proteoglycans in cancer_Homo sapiens_hsa052050.88195362
67Gastric acid secretion_Homo sapiens_hsa049710.87710691
68Estrogen signaling pathway_Homo sapiens_hsa049150.87501088
69Olfactory transduction_Homo sapiens_hsa047400.86311357
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84666610
71Hepatitis C_Homo sapiens_hsa051600.83859361
72Insulin resistance_Homo sapiens_hsa049310.83062128
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82825997
74Graft-versus-host disease_Homo sapiens_hsa053320.81766437
75Type I diabetes mellitus_Homo sapiens_hsa049400.81188208
76Tuberculosis_Homo sapiens_hsa051520.80299862
77Renin secretion_Homo sapiens_hsa049240.78587920
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78349347
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78017530
80HIF-1 signaling pathway_Homo sapiens_hsa040660.77981868
81MAPK signaling pathway_Homo sapiens_hsa040100.77438220
82Lysine degradation_Homo sapiens_hsa003100.76102928
83Other glycan degradation_Homo sapiens_hsa005110.75909861
84HTLV-I infection_Homo sapiens_hsa051660.75441041
85Cholinergic synapse_Homo sapiens_hsa047250.74930240
86Adherens junction_Homo sapiens_hsa045200.73876935
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73732197
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73415271
89Dopaminergic synapse_Homo sapiens_hsa047280.73270453
90Allograft rejection_Homo sapiens_hsa053300.73151001
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.73023139
92ABC transporters_Homo sapiens_hsa020100.72669857
93Long-term depression_Homo sapiens_hsa047300.71740836
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.71688546
95Notch signaling pathway_Homo sapiens_hsa043300.71246617
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71227395
97Viral carcinogenesis_Homo sapiens_hsa052030.70160150
98Bladder cancer_Homo sapiens_hsa052190.69933418
99FoxO signaling pathway_Homo sapiens_hsa040680.69786462
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69396121
101Small cell lung cancer_Homo sapiens_hsa052220.69107558
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.68973476
103Renal cell carcinoma_Homo sapiens_hsa052110.68818272
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68366924
105Viral myocarditis_Homo sapiens_hsa054160.67805441
106Insulin signaling pathway_Homo sapiens_hsa049100.67653774
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67275270
108GnRH signaling pathway_Homo sapiens_hsa049120.65861759
109mRNA surveillance pathway_Homo sapiens_hsa030150.65812110
110Amphetamine addiction_Homo sapiens_hsa050310.64732703
111Apoptosis_Homo sapiens_hsa042100.64497097
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64402732
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.63736725
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63313050
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62967182
116Oxytocin signaling pathway_Homo sapiens_hsa049210.62839337
117Shigellosis_Homo sapiens_hsa051310.61570989
118GABAergic synapse_Homo sapiens_hsa047270.61230930
119Insulin secretion_Homo sapiens_hsa049110.61165973
120African trypanosomiasis_Homo sapiens_hsa051430.61157649
121cAMP signaling pathway_Homo sapiens_hsa040240.60769398
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60648889
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60594116
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60404085
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60288811
126Prostate cancer_Homo sapiens_hsa052150.59645047
127Pancreatic secretion_Homo sapiens_hsa049720.59573119
128Pertussis_Homo sapiens_hsa051330.54131069
129Salmonella infection_Homo sapiens_hsa051320.53904604
130Epstein-Barr virus infection_Homo sapiens_hsa051690.51827201
131Pathways in cancer_Homo sapiens_hsa052000.51365639

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