ATP11C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.46495011
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.46495011
3L-phenylalanine metabolic process (GO:0006558)7.09040203
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.09040203
5aromatic amino acid family catabolic process (GO:0009074)6.95935224
6nuclear pore complex assembly (GO:0051292)6.71594729
7tryptophan catabolic process (GO:0006569)6.49732483
8indole-containing compound catabolic process (GO:0042436)6.49732483
9indolalkylamine catabolic process (GO:0046218)6.49732483
10nuclear pore organization (GO:0006999)6.29686029
11kynurenine metabolic process (GO:0070189)6.29259939
12bile acid biosynthetic process (GO:0006699)6.19261798
13tryptophan metabolic process (GO:0006568)6.10827154
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.09212845
15urea cycle (GO:0000050)5.92647198
16urea metabolic process (GO:0019627)5.92647198
17complement activation, alternative pathway (GO:0006957)5.85396749
18glyoxylate metabolic process (GO:0046487)5.80705878
19alpha-linolenic acid metabolic process (GO:0036109)5.75497847
20regulation of protein activation cascade (GO:2000257)5.75003555
21negative regulation of fibrinolysis (GO:0051918)5.68240502
22regulation of fibrinolysis (GO:0051917)5.48939950
23cysteine metabolic process (GO:0006534)5.47333114
24protein carboxylation (GO:0018214)5.42412792
25peptidyl-glutamic acid carboxylation (GO:0017187)5.42412792
26nitrogen cycle metabolic process (GO:0071941)5.41448873
27regulation of complement activation (GO:0030449)5.41316554
28sulfur amino acid catabolic process (GO:0000098)5.29799312
29mitotic sister chromatid cohesion (GO:0007064)5.29420025
30high-density lipoprotein particle remodeling (GO:0034375)5.28841569
31bile acid metabolic process (GO:0008206)5.20351294
32serine family amino acid catabolic process (GO:0009071)5.17299496
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.09682645
34homocysteine metabolic process (GO:0050667)5.02393598
35aromatic amino acid family metabolic process (GO:0009072)5.01912090
36tyrosine metabolic process (GO:0006570)4.82036518
37regulation of triglyceride catabolic process (GO:0010896)4.72411549
38pore complex assembly (GO:0046931)4.69183864
39alpha-amino acid catabolic process (GO:1901606)4.66741610
40reverse cholesterol transport (GO:0043691)4.62750029
41glycine metabolic process (GO:0006544)4.60775360
42lysine catabolic process (GO:0006554)4.60646433
43lysine metabolic process (GO:0006553)4.60646433
44amino-acid betaine metabolic process (GO:0006577)4.60318320
45protein-lipid complex remodeling (GO:0034368)4.60284359
46macromolecular complex remodeling (GO:0034367)4.60284359
47plasma lipoprotein particle remodeling (GO:0034369)4.60284359
48bile acid and bile salt transport (GO:0015721)4.56680688
49indolalkylamine metabolic process (GO:0006586)4.55046761
50acylglycerol homeostasis (GO:0055090)4.54974551
51triglyceride homeostasis (GO:0070328)4.54974551
52imidazole-containing compound metabolic process (GO:0052803)4.53044058
53regulation of cholesterol esterification (GO:0010872)4.49141331
54mitotic metaphase plate congression (GO:0007080)4.47204874
55negative regulation of sterol transport (GO:0032372)4.45635379
56negative regulation of cholesterol transport (GO:0032375)4.45635379
57phospholipid efflux (GO:0033700)4.40275475
58cellular biogenic amine catabolic process (GO:0042402)4.39195343
59amine catabolic process (GO:0009310)4.39195343
60pre-miRNA processing (GO:0031054)4.35280926
61coenzyme catabolic process (GO:0009109)4.34919408
62chromatin remodeling at centromere (GO:0031055)4.34699336
63cellular glucuronidation (GO:0052695)4.33161401
64DNA unwinding involved in DNA replication (GO:0006268)4.29344399
65serine family amino acid metabolic process (GO:0009069)4.28663223
66plasma lipoprotein particle clearance (GO:0034381)4.28033763
67cellular amino acid catabolic process (GO:0009063)4.25146340
68CENP-A containing nucleosome assembly (GO:0034080)4.24917488
69protein localization to kinetochore (GO:0034501)4.22597863
70glutamate metabolic process (GO:0006536)4.19857657
71ethanol oxidation (GO:0006069)4.17232694
72benzene-containing compound metabolic process (GO:0042537)4.17100165
73dicarboxylic acid biosynthetic process (GO:0043650)4.14367509
74serine family amino acid biosynthetic process (GO:0009070)4.13070010
75cellular ketone body metabolic process (GO:0046950)4.12781298
76cholesterol efflux (GO:0033344)4.11267251
77complement activation, classical pathway (GO:0006958)4.06312581
78fibrinolysis (GO:0042730)4.04172252
79complement activation (GO:0006956)4.02233893
80protein localization to chromosome, centromeric region (GO:0071459)4.00787854
81cellular modified amino acid catabolic process (GO:0042219)3.99919079
82arginine metabolic process (GO:0006525)3.99807477
83metaphase plate congression (GO:0051310)3.99688989
84low-density lipoprotein particle remodeling (GO:0034374)3.99557583
85cytolysis (GO:0019835)3.98514239
86regulation of centriole replication (GO:0046599)3.98172345
87plasma lipoprotein particle assembly (GO:0034377)3.96830004
88DNA replication checkpoint (GO:0000076)3.96202423
89blood coagulation, intrinsic pathway (GO:0007597)3.95640908
90protein activation cascade (GO:0072376)3.93336238
91establishment of integrated proviral latency (GO:0075713)3.92385144
92histone exchange (GO:0043486)3.88801854
93phospholipid homeostasis (GO:0055091)3.88283777
94double-strand break repair via nonhomologous end joining (GO:0006303)3.86885557
95non-recombinational repair (GO:0000726)3.86885557
96aldehyde catabolic process (GO:0046185)3.84644516
97regulation of meiosis I (GO:0060631)3.79697192
98very-low-density lipoprotein particle assembly (GO:0034379)3.77907737
99uronic acid metabolic process (GO:0006063)3.77445316
100glucuronate metabolic process (GO:0019585)3.77445316
101synapsis (GO:0007129)3.77283908
102sister chromatid segregation (GO:0000819)3.75829940
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.75709691
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.75709691
105negative regulation of mitotic sister chromatid segregation (GO:0033048)3.75709691
106negative regulation of mitotic sister chromatid separation (GO:2000816)3.75709691
107negative regulation of sister chromatid segregation (GO:0033046)3.75709691
108regulation of bile acid biosynthetic process (GO:0070857)3.74192888
109cofactor catabolic process (GO:0051187)3.74017400
110negative regulation of chromosome segregation (GO:0051985)3.73966017
111positive regulation of lipid catabolic process (GO:0050996)3.72152352
112sister chromatid cohesion (GO:0007062)3.70430965
113cholesterol homeostasis (GO:0042632)3.69862862
114acetyl-CoA metabolic process (GO:0006084)3.69732049
115drug catabolic process (GO:0042737)3.68055049
116regulation of DNA endoreduplication (GO:0032875)3.67598697
117organic acid catabolic process (GO:0016054)3.67496006
118carboxylic acid catabolic process (GO:0046395)3.67496006
119mitotic spindle checkpoint (GO:0071174)3.66541786
120negative regulation of DNA repair (GO:0045738)3.64813330
121sterol homeostasis (GO:0055092)3.63876287
122pyridine nucleotide biosynthetic process (GO:0019363)3.63247952
123nicotinamide nucleotide biosynthetic process (GO:0019359)3.63247952
124NAD biosynthetic process (GO:0009435)3.63031767
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.62751572
126regulation of mitotic metaphase/anaphase transition (GO:0030071)3.62751572
127DNA replication initiation (GO:0006270)3.62353283
128mitotic spindle assembly checkpoint (GO:0007094)3.60380498
129regulation of cholesterol homeostasis (GO:2000188)3.60030773
130spindle checkpoint (GO:0031577)3.59552098
131DNA replication-independent nucleosome organization (GO:0034724)3.57353409
132DNA replication-independent nucleosome assembly (GO:0006336)3.57353409
133ketone body metabolic process (GO:1902224)3.56878322
134opsonization (GO:0008228)3.54672437
135regulation of mitotic sister chromatid separation (GO:0010965)3.54494632
136regulation of mitotic sister chromatid segregation (GO:0033047)3.54494632
137regulation of sister chromatid segregation (GO:0033045)3.54494632
138positive regulation of triglyceride lipase activity (GO:0061365)3.54072765
139positive regulation of lipoprotein lipase activity (GO:0051006)3.54072765
140spindle assembly checkpoint (GO:0071173)3.54003764
141plasma lipoprotein particle organization (GO:0071827)3.53990485
142protein-lipid complex assembly (GO:0065005)3.53653525
143mitotic sister chromatid segregation (GO:0000070)3.52941622
144mitotic nuclear envelope disassembly (GO:0007077)3.51096159
145mitotic chromosome condensation (GO:0007076)3.49312137
146negative regulation of DNA-dependent DNA replication (GO:2000104)3.48911887
147ribosome assembly (GO:0042255)3.47804515
148regulation of chromosome segregation (GO:0051983)3.43692163
149regulation of helicase activity (GO:0051095)3.43128977
150heterochromatin organization (GO:0070828)3.40046662
151mitotic G2/M transition checkpoint (GO:0044818)3.38913744
152DNA synthesis involved in DNA repair (GO:0000731)3.38471244
153DNA strand elongation involved in DNA replication (GO:0006271)3.37916085
154positive regulation of SMAD protein import into nucleus (GO:0060391)3.35301723
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34172373
156DNA ligation (GO:0006266)3.32007375
157membrane disassembly (GO:0030397)3.31351787
158nuclear envelope disassembly (GO:0051081)3.31351787
159DNA topological change (GO:0006265)3.30515105
160DNA duplex unwinding (GO:0032508)3.28461128
161establishment of chromosome localization (GO:0051303)3.28301950
162DNA strand elongation (GO:0022616)3.27403439
163kinetochore organization (GO:0051383)3.26387573
164regulation of histone H3-K9 methylation (GO:0051570)3.25910462
165DNA geometric change (GO:0032392)3.23570997
166somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22962861
167somatic hypermutation of immunoglobulin genes (GO:0016446)3.22962861
168ATP-dependent chromatin remodeling (GO:0043044)3.21969395
169regulation of centrosome cycle (GO:0046605)3.19100192
170DNA replication-dependent nucleosome organization (GO:0034723)3.11494158
171DNA replication-dependent nucleosome assembly (GO:0006335)3.11494158
172anterior/posterior axis specification, embryo (GO:0008595)3.07986341
173regulation of centrosome duplication (GO:0010824)3.07159164
174regulation of mitotic spindle checkpoint (GO:1903504)3.06368386
175regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06368386
176telomere maintenance via semi-conservative replication (GO:0032201)3.04610503
177IMP biosynthetic process (GO:0006188)3.03982364
178regulation of sister chromatid cohesion (GO:0007063)3.01280113
179mitotic recombination (GO:0006312)3.01269363
180positive regulation of chromosome segregation (GO:0051984)3.00337042
181paraxial mesoderm development (GO:0048339)2.99658448
182response to X-ray (GO:0010165)2.98748918
183purine nucleobase biosynthetic process (GO:0009113)2.89275218
184negative regulation of mitosis (GO:0045839)2.88839676
185formation of translation preinitiation complex (GO:0001731)2.86521949
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.85497391
187attachment of spindle microtubules to kinetochore (GO:0008608)2.85308228
188DNA double-strand break processing (GO:0000729)2.84939281
189negative regulation of fibroblast apoptotic process (GO:2000270)2.84606437
190telomere maintenance via recombination (GO:0000722)2.84479348
191regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.83456794
192resolution of meiotic recombination intermediates (GO:0000712)2.82562394
193meiotic chromosome segregation (GO:0045132)2.80787785
194IMP metabolic process (GO:0046040)2.78892369
195regulation of RNA export from nucleus (GO:0046831)2.78028595
196chromatin assembly or disassembly (GO:0006333)2.77643323
197DNA conformation change (GO:0071103)2.74055154
198protein localization to chromosome (GO:0034502)2.73291268
199negative regulation of DNA recombination (GO:0045910)2.72696229
200positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.70629565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37726341
2RXR_22158963_ChIP-Seq_LIVER_Mouse8.35458003
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.37809852
4PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16761242
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.52764186
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18470200
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10039198
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.50832672
9SALL1_21062744_ChIP-ChIP_HESCs_Human4.37635621
10E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19063775
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.10295360
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00643547
13RBPJ_22232070_ChIP-Seq_NCS_Mouse3.77817305
14FOXM1_23109430_ChIP-Seq_U2OS_Human3.56174639
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.33935377
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.57573559
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45065918
18EWS_26573619_Chip-Seq_HEK293_Human2.32558404
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.29186265
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24963188
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17741435
22ELK1_19687146_ChIP-ChIP_HELA_Human2.09892203
23FUS_26573619_Chip-Seq_HEK293_Human2.06772613
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06089207
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04474594
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02485141
27GATA1_22025678_ChIP-Seq_K562_Human2.01289484
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8611045
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93022505
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91947824
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.91564603
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86669538
33* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.79241011
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78093368
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76729667
36IGF1R_20145208_ChIP-Seq_DFB_Human1.76710793
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74481043
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.73914939
39CLOCK_20551151_ChIP-Seq_293T_Human1.72739883
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71738497
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71738497
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71738497
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70834091
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.68438976
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66301027
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65825683
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.65632919
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65356621
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64736985
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.64555986
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.64044810
52IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61173107
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61019619
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60214572
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.57360350
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.56925508
57HTT_18923047_ChIP-ChIP_STHdh_Human1.55105014
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52905344
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51952505
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49416267
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42867304
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42836734
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.41762699
64* NANOG_16153702_ChIP-ChIP_HESCs_Human1.41154077
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.40181697
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35627859
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33959778
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30740136
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28604645
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25916369
71CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25727457
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.21078417
73P300_19829295_ChIP-Seq_ESCs_Human1.20155496
74MYC_18940864_ChIP-ChIP_HL60_Human1.17975829
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11694234
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10075182
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.09579384
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08399541
79DCP1A_22483619_ChIP-Seq_HELA_Human1.07977552
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07927300
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07757162
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07356209
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06285398
84VDR_23849224_ChIP-Seq_CD4+_Human1.05636729
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.04943339
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04199494
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03079123
88FOXP3_21729870_ChIP-Seq_TREG_Human1.03032550
89TTF2_22483619_ChIP-Seq_HELA_Human1.02932426
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02605616
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02177800
92BRD4_25478319_ChIP-Seq_HGPS_Human1.01148424
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00887134
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00725170
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99582685
96ZNF274_21170338_ChIP-Seq_K562_Hela0.98628620
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.96609634
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95423101
99TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94623066
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94543274
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94448579
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93936516
103TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93448409
104GBX2_23144817_ChIP-Seq_PC3_Human0.93013647
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92303800
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92158432
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90438230
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90368139
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90149109
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90002926
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89988843
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89775348
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88747292
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88540983
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88303464
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88294326
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85993714
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85623719
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85112088
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84952428
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84682707
122GATA4_25053715_ChIP-Seq_YYC3_Human0.84106366
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.83969815
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81862476
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81848921
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81168821
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80682010
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80364334
129TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80258843
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80180627
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77895072
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76057387
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70660073
134SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67744209
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67715450
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.66778425
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.66573673
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65983507
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.65401601
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65231205
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64714681
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.63761481
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.60724085
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.60571458
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.60067659
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.59985804
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.59985804
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.59945052
149ZNF263_19887448_ChIP-Seq_K562_Human0.59329377
150* FOXA1_25552417_ChIP-Seq_VCAP_Human0.59302610
151CEBPB_22108803_ChIP-Seq_LS180_Human0.58200866
152SCL_19346495_ChIP-Seq_HPC-7_Human0.58075740
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57657238
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.54684908
155PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54649909
156RARB_24833708_ChIP-Seq_LIVER_Mouse0.53399296
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.52726780
158FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50259577
159GATA2_19941826_ChIP-Seq_K562_Human0.49506591
160RARG_19884340_ChIP-ChIP_MEFs_Mouse0.49119127
161GATA1_19941826_ChIP-Seq_K562_Human0.48535994
162GATA6_25053715_ChIP-Seq_YYC3_Human0.47881650
163ESR2_21235772_ChIP-Seq_MCF-7_Human0.47297888
164TAF15_26573619_Chip-Seq_HEK293_Human0.45887901
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.45850272
166AR_20517297_ChIP-Seq_VCAP_Human0.45837881
167CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45829658
168STAT1_17558387_ChIP-Seq_HELA_Human0.45723380
169ESR1_21235772_ChIP-Seq_MCF-7_Human0.45707718
170PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45199463
171EGR1_19032775_ChIP-ChIP_M12_Human0.44899048
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.43427382
173CBP_21632823_ChIP-Seq_H3396_Human0.42347969
174GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.42154470
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.42106144
176BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.41689601
177MYB_21317192_ChIP-Seq_ERMYB_Mouse0.39521166
178ESR1_20079471_ChIP-ChIP_T-47D_Human0.37832965
179MYC_19915707_ChIP-ChIP_AK7_Human0.37504740
180AR_21909140_ChIP-Seq_LNCAP_Human0.37113376
181GATA2_22383799_ChIP-Seq_G1ME_Mouse0.36881636
182PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.36850371
183CDX2_22108803_ChIP-Seq_LS180_Human0.36656683
184BCAT_22108803_ChIP-Seq_LS180_Human0.36571771
185SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36406896
186NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.35555828
187GATA3_26560356_Chip-Seq_TH1_Human0.34368005
188IRF8_21731497_ChIP-ChIP_J774_Mouse0.33616521
189GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.33601898
190P53_21459846_ChIP-Seq_SAOS-2_Human0.33546477
191AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.33069675
192CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.31399372
193RAD21_21589869_ChIP-Seq_MESCs_Mouse0.31083194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.23748532
2MP0005360_urolithiasis7.50100625
3MP0005085_abnormal_gallbladder_physiolo6.43791653
4MP0005365_abnormal_bile_salt6.17154511
5MP0008875_abnormal_xenobiotic_pharmacok4.94019314
6MP0008057_abnormal_DNA_replication4.85293039
7MP0003806_abnormal_nucleotide_metabolis4.04526109
8MP0003252_abnormal_bile_duct4.03198154
9MP0010094_abnormal_chromosome_stability3.82291575
10MP0010329_abnormal_lipoprotein_level3.49068058
11MP0003890_abnormal_embryonic-extraembry3.35001027
12MP0004957_abnormal_blastocyst_morpholog3.23597373
13MP0003693_abnormal_embryo_hatching3.11823755
14MP0008058_abnormal_DNA_repair3.08465603
15MP0003941_abnormal_skin_development2.92277450
16MP0005083_abnormal_biliary_tract2.91443542
17MP0003111_abnormal_nucleus_morphology2.88562040
18MP0009840_abnormal_foam_cell2.87500511
19MP0005332_abnormal_amino_acid2.58904116
20MP0003077_abnormal_cell_cycle2.54021309
21MP0010352_gastrointestinal_tract_polyps2.52859753
22MP0001666_abnormal_nutrient_absorption2.52686268
23MP0003195_calcinosis2.45983920
24MP0008877_abnormal_DNA_methylation2.39682361
25MP0003567_abnormal_fetal_cardiomyocyte2.37369954
26MP0008932_abnormal_embryonic_tissue2.28192631
27MP0003191_abnormal_cellular_cholesterol2.25334826
28MP0000609_abnormal_liver_physiology2.22121034
29MP0003937_abnormal_limbs/digits/tail_de2.17294728
30MP0002138_abnormal_hepatobiliary_system2.13522661
31MP0008007_abnormal_cellular_replicative2.08029405
32MP0001293_anophthalmia2.01722762
33MP0003868_abnormal_feces_composition2.00545539
34MP0002118_abnormal_lipid_homeostasis1.99856556
35MP0004019_abnormal_vitamin_homeostasis1.99203841
36MP0001730_embryonic_growth_arrest1.97314692
37MP0002084_abnormal_developmental_patter1.94090055
38MP0004272_abnormal_basement_membrane1.85472253
39MP0009697_abnormal_copulation1.83884110
40MP0005319_abnormal_enzyme/_coenzyme1.83345334
41MP0001672_abnormal_embryogenesis/_devel1.79462501
42MP0005380_embryogenesis_phenotype1.79462501
43MP0010030_abnormal_orbit_morphology1.79159830
44MP0000428_abnormal_craniofacial_morphol1.73259778
45MP0001188_hyperpigmentation1.71452642
46MP0002009_preneoplasia1.70693904
47MP0010307_abnormal_tumor_latency1.69745200
48MP0002697_abnormal_eye_size1.64457821
49MP0000350_abnormal_cell_proliferation1.63621486
50MP0003984_embryonic_growth_retardation1.61974530
51MP0001764_abnormal_homeostasis1.61319713
52MP0002877_abnormal_melanocyte_morpholog1.61129570
53MP0002085_abnormal_embryonic_tissue1.60916632
54MP0002088_abnormal_embryonic_growth/wei1.60831816
55MP0001697_abnormal_embryo_size1.60438168
56MP0000537_abnormal_urethra_morphology1.55552867
57MP0005584_abnormal_enzyme/coenzyme_acti1.49600033
58MP0006292_abnormal_olfactory_placode1.49497824
59MP0008438_abnormal_cutaneous_collagen1.46278790
60MP0002233_abnormal_nose_morphology1.45540246
61MP0002086_abnormal_extraembryonic_tissu1.40665083
62MP0000569_abnormal_digit_pigmentation1.37898163
63MP0002396_abnormal_hematopoietic_system1.36061374
64MP0009703_decreased_birth_body1.35285863
65MP0001299_abnormal_eye_distance/1.34696509
66MP0003385_abnormal_body_wall1.33880829
67MP0004197_abnormal_fetal_growth/weight/1.32237925
68MP0003935_abnormal_craniofacial_develop1.31634572
69MP0005451_abnormal_body_composition1.30592707
70MP0001286_abnormal_eye_development1.30190684
71MP0003656_abnormal_erythrocyte_physiolo1.30022087
72MP0001879_abnormal_lymphatic_vessel1.29886743
73MP0000598_abnormal_liver_morphology1.29680477
74MP0005647_abnormal_sex_gland1.29583726
75MP0003705_abnormal_hypodermis_morpholog1.28292548
76MP0000049_abnormal_middle_ear1.27864095
77MP0002080_prenatal_lethality1.27539683
78MP0002092_abnormal_eye_morphology1.26442336
79MP0003186_abnormal_redox_activity1.25367157
80MP0000432_abnormal_head_morphology1.18738807
81MP0001177_atelectasis1.17625396
82MP0003011_delayed_dark_adaptation1.16217530
83MP0009764_decreased_sensitivity_to1.15948283
84MP0009643_abnormal_urine_homeostasis1.15620184
85MP0009763_increased_sensitivity_to1.12820295
86MP0003119_abnormal_digestive_system1.12596151
87MP0010368_abnormal_lymphatic_system1.08420798
88MP0002102_abnormal_ear_morphology1.07891855
89MP0003755_abnormal_palate_morphology1.06420348
90MP0002111_abnormal_tail_morphology1.04866569
91MP0009250_abnormal_appendicular_skeleto1.04789267
92MP0002210_abnormal_sex_determination1.04704230
93MP0005187_abnormal_penis_morphology1.02553550
94MP0008469_abnormal_protein_level1.01628863
95MP0002254_reproductive_system_inflammat0.98639804
96MP0003786_premature_aging0.94241354
97MP0000313_abnormal_cell_death0.92752448
98MP0005408_hypopigmentation0.92660340
99MP0005623_abnormal_meninges_morphology0.92492991
100MP0006054_spinal_hemorrhage0.91951145
101MP0004808_abnormal_hematopoietic_stem0.89383206
102MP0003861_abnormal_nervous_system0.88266343
103MP0001929_abnormal_gametogenesis0.87897006
104MP0002751_abnormal_autonomic_nervous0.87694928
105MP0001145_abnormal_male_reproductive0.86814704
106MP0003315_abnormal_perineum_morphology0.85504384
107MP0000604_amyloidosis0.84991778
108MP0003115_abnormal_respiratory_system0.84638631
109MP0009642_abnormal_blood_homeostasis0.84550880
110MP0000653_abnormal_sex_gland0.84273110
111MP0009765_abnormal_xenobiotic_induced0.84112959
112MP0003221_abnormal_cardiomyocyte_apopto0.83285051
113MP0001119_abnormal_female_reproductive0.83076924
114MP0005275_abnormal_skin_tensile0.81599796
115MP0005084_abnormal_gallbladder_morpholo0.80967871
116MP0003436_decreased_susceptibility_to0.80855275
117MP0002925_abnormal_cardiovascular_devel0.80506710
118MP0005636_abnormal_mineral_homeostasis0.80098092
119MP0005464_abnormal_platelet_physiology0.79548188
120MP0005220_abnormal_exocrine_pancreas0.79360873
121MP0002114_abnormal_axial_skeleton0.78597536
122MP0005076_abnormal_cell_differentiation0.76425699
123MP0005670_abnormal_white_adipose0.73836155
124MP0000647_abnormal_sebaceous_gland0.73797933
125MP0000762_abnormal_tongue_morphology0.73442408
126MP0005376_homeostasis/metabolism_phenot0.73290940
127MP0002109_abnormal_limb_morphology0.72895289
128MP0005334_abnormal_fat_pad0.72492936
129MP0003942_abnormal_urinary_system0.72425355
130MP0004134_abnormal_chest_morphology0.71979373
131MP0005391_vision/eye_phenotype0.71202503
132MP0009053_abnormal_anal_canal0.70045512
133MP0003724_increased_susceptibility_to0.69930864
134MP0002938_white_spotting0.69333338
135MP0004130_abnormal_muscle_cell0.68898940
136MP0002081_perinatal_lethality0.68873325
137MP0002971_abnormal_brown_adipose0.67758598
138MP0002928_abnormal_bile_duct0.65102313
139MP0002078_abnormal_glucose_homeostasis0.65093396
140MP0000358_abnormal_cell_content/0.64182408
141MP0002160_abnormal_reproductive_system0.64147412
142MP0003566_abnormal_cell_adhesion0.63709812
143MP0002116_abnormal_craniofacial_bone0.63698056
144MP0006036_abnormal_mitochondrial_physio0.61746259
145MP0001661_extended_life_span0.58384921
146MP0005266_abnormal_metabolism0.57418291
147MP0003690_abnormal_glial_cell0.56050905
148MP0001853_heart_inflammation0.55154642
149MP0002876_abnormal_thyroid_physiology0.54993385
150MP0005535_abnormal_body_temperature0.54358937
151MP0000639_abnormal_adrenal_gland0.50271286
152MP0008873_increased_physiological_sensi0.49235930
153MP0002136_abnormal_kidney_physiology0.48227063
154MP0004381_abnormal_hair_follicle0.47736673
155MP0004782_abnormal_surfactant_physiolog0.47571551
156MP0005248_abnormal_Harderian_gland0.47231182
157MP0001756_abnormal_urination0.47043940
158MP0005448_abnormal_energy_balance0.45924309
159MP0006035_abnormal_mitochondrial_morpho0.45884147
160MP0005395_other_phenotype0.45856819
161MP0005166_decreased_susceptibility_to0.45124853
162MP0001845_abnormal_inflammatory_respons0.43638535
163MP0009115_abnormal_fat_cell0.42248541
164MP0003638_abnormal_response/metabolism_0.41803648
165MP0003300_gastrointestinal_ulcer0.41543553
166MP0009672_abnormal_birth_weight0.41512567
167MP0006082_CNS_inflammation0.41125390
168MP0003718_maternal_effect0.39714651
169MP0005666_abnormal_adipose_tissue0.38231326
170MP0009384_cardiac_valve_regurgitation0.37441851
171MP0001835_abnormal_antigen_presentation0.37334627
172MP0000249_abnormal_blood_vessel0.36568682
173MP0002970_abnormal_white_adipose0.34992153
174MP0002419_abnormal_innate_immunity0.34571049
175MP0008874_decreased_physiological_sensi0.34520816
176MP0002132_abnormal_respiratory_system0.34268988
177MP0010234_abnormal_vibrissa_follicle0.34057513
178MP0001881_abnormal_mammary_gland0.32900963
179MP0005025_abnormal_response_to0.32750260
180MP0009785_altered_susceptibility_to0.32008967
181MP0001915_intracranial_hemorrhage0.31816903
182MP0003075_altered_response_to0.31312289
183MP0003943_abnormal_hepatobiliary_system0.30935381
184MP0002168_other_aberrant_phenotype0.30604533
185MP0000427_abnormal_hair_cycle0.30441138
186MP0002135_abnormal_kidney_morphology0.29520605
187MP0001243_abnormal_dermal_layer0.29335031
188MP0003453_abnormal_keratinocyte_physiol0.28995663
189MP0003953_abnormal_hormone_level0.28525111

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.52778802
2Deep venous thrombosis (HP:0002625)7.52384084
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.08594740
4Prolonged partial thromboplastin time (HP:0003645)6.67490990
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65996885
6Hypobetalipoproteinemia (HP:0003563)6.49639031
7Xanthomatosis (HP:0000991)6.16497054
8Complement deficiency (HP:0004431)5.94643573
9Hyperlipoproteinemia (HP:0010980)5.34937939
10Joint hemorrhage (HP:0005261)5.00149604
11Epidermoid cyst (HP:0200040)4.81720409
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.76499335
13Hypolipoproteinemia (HP:0010981)4.74097771
14Abnormality of the common coagulation pathway (HP:0010990)4.67172119
15Chromsome breakage (HP:0040012)4.58825880
16Hyperammonemia (HP:0001987)4.43363012
17Abnormality of methionine metabolism (HP:0010901)4.39428276
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.37691924
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.36892711
20Abnormality of complement system (HP:0005339)4.34267798
21Fat malabsorption (HP:0002630)4.29533625
22Hyperglycinemia (HP:0002154)4.22401305
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20367272
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07472159
25Hypoalphalipoproteinemia (HP:0003233)4.00913016
26Ketosis (HP:0001946)3.95604871
27Abnormality of pyrimidine metabolism (HP:0004353)3.92134051
28Abnormality of chromosome stability (HP:0003220)3.92053749
29Abnormality of the intrinsic pathway (HP:0010989)3.90889726
30Hypochromic microcytic anemia (HP:0004840)3.89638795
31Conjugated hyperbilirubinemia (HP:0002908)3.76322245
32Hypercholesterolemia (HP:0003124)3.72542778
33Hyperglycinuria (HP:0003108)3.71126621
34Abnormality of serine family amino acid metabolism (HP:0010894)3.68007657
35Abnormality of glycine metabolism (HP:0010895)3.68007657
36Hypoglycemic coma (HP:0001325)3.65123170
37Myocardial infarction (HP:0001658)3.35367214
38Aplasia/Hypoplasia of the uvula (HP:0010293)3.34288584
39Hyperbilirubinemia (HP:0002904)3.27874390
40Volvulus (HP:0002580)3.25058087
41Steatorrhea (HP:0002570)3.23343874
42Abnormality of fatty-acid metabolism (HP:0004359)3.17501110
43Spontaneous abortion (HP:0005268)3.17237193
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16695285
45Meckel diverticulum (HP:0002245)3.16257157
46Hepatocellular carcinoma (HP:0001402)3.16199506
47Recurrent gram-negative bacterial infections (HP:0005420)3.13292220
48Nephroblastoma (Wilms tumor) (HP:0002667)3.13098907
49Embryonal renal neoplasm (HP:0011794)3.13057225
50Rhabdomyosarcoma (HP:0002859)3.10875644
51Abnormality of nucleobase metabolism (HP:0010932)3.03631312
52Systemic lupus erythematosus (HP:0002725)3.03048161
53Abnormality of serum amino acid levels (HP:0003112)3.00792607
54Abnormality of the ileum (HP:0001549)2.97793630
55Delayed CNS myelination (HP:0002188)2.90227899
56Acanthocytosis (HP:0001927)2.89751842
57Abnormal lung lobation (HP:0002101)2.88220239
58Abnormality of the preputium (HP:0100587)2.82058308
59Skin nodule (HP:0200036)2.80707806
60Medulloblastoma (HP:0002885)2.78000780
61Duodenal stenosis (HP:0100867)2.77892499
62Small intestinal stenosis (HP:0012848)2.77892499
63Spastic diplegia (HP:0001264)2.70906494
64Gonadotropin excess (HP:0000837)2.70219048
65Ketoacidosis (HP:0001993)2.63235140
66Colon cancer (HP:0003003)2.60230885
67Abnormality of purine metabolism (HP:0004352)2.59379942
68Glomerulonephritis (HP:0000099)2.58547781
69Abnormality of the duodenum (HP:0002246)2.56651714
70Ectopic kidney (HP:0000086)2.55368569
71Mitral stenosis (HP:0001718)2.54968959
72Gingival bleeding (HP:0000225)2.54917339
73Metabolic acidosis (HP:0001942)2.46931177
74Esophageal varix (HP:0002040)2.45111710
75Increased nuchal translucency (HP:0010880)2.44876650
76Vascular calcification (HP:0004934)2.44406869
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36880595
78Dicarboxylic aciduria (HP:0003215)2.36880595
79Cortical dysplasia (HP:0002539)2.36025361
80Short middle phalanx of the 5th finger (HP:0004220)2.33784989
81Glioma (HP:0009733)2.30389029
82Thrombophlebitis (HP:0004418)2.30165704
83Lethargy (HP:0001254)2.29572445
84Abnormal gallbladder morphology (HP:0012437)2.28211846
85Papillary thyroid carcinoma (HP:0002895)2.26826018
86Poikilocytosis (HP:0004447)2.25910318
87Cholelithiasis (HP:0001081)2.25225812
88Abnormality of the labia minora (HP:0012880)2.25148424
89Absent radius (HP:0003974)2.25057853
90Menorrhagia (HP:0000132)2.24298181
91Neonatal onset (HP:0003623)2.22047004
92Capillary hemangiomas (HP:0005306)2.20586848
93Bifid tongue (HP:0010297)2.20040912
94Hypoglycemic seizures (HP:0002173)2.19246256
95Proximal placement of thumb (HP:0009623)2.18119169
96Hepatoblastoma (HP:0002884)2.17580120
97Cardiovascular calcification (HP:0011915)2.17223457
98Hemorrhage of the eye (HP:0011885)2.16232300
99Deviation of the thumb (HP:0009603)2.15490936
100Single umbilical artery (HP:0001195)2.14674511
101Abnormality of the fetal cardiovascular system (HP:0010948)2.14674511
102Abnormal umbilical cord blood vessels (HP:0011403)2.14674511
103Gout (HP:0001997)2.14314963
104Irritability (HP:0000737)2.13967436
105Myelodysplasia (HP:0002863)2.13184852
106Clubbing of toes (HP:0100760)2.12319232
107Enlarged kidneys (HP:0000105)2.11645180
108Mesomelia (HP:0003027)2.11457828
109Astrocytoma (HP:0009592)2.10913025
110Abnormality of the astrocytes (HP:0100707)2.10913025
111Abnormality of the carotid arteries (HP:0005344)2.09187737
112Birth length less than 3rd percentile (HP:0003561)2.09157709
113Sensorimotor neuropathy (HP:0007141)2.08616187
114Acute myeloid leukemia (HP:0004808)2.07813997
115Aplasia involving forearm bones (HP:0009822)2.07655070
116Absent forearm bone (HP:0003953)2.07655070
117Gastrointestinal carcinoma (HP:0002672)2.07059188
118Malignant gastrointestinal tract tumors (HP:0006749)2.07059188
119Arteriovenous malformation (HP:0100026)2.07011085
120Cerebral edema (HP:0002181)2.06634964
121Sloping forehead (HP:0000340)2.06524313
122Aplasia/Hypoplasia of the sternum (HP:0006714)2.06330291
123Ependymoma (HP:0002888)2.04052810
124Pancreatitis (HP:0001733)2.03934102
125Amyloidosis (HP:0011034)2.01913470
126Deep philtrum (HP:0002002)2.01104919
127Malnutrition (HP:0004395)1.99920591
128Renal cortical cysts (HP:0000803)1.99608078
129Embryonal neoplasm (HP:0002898)1.97102779
130Cholecystitis (HP:0001082)1.95219868
131Abnormal gallbladder physiology (HP:0012438)1.95219868
132Generalized aminoaciduria (HP:0002909)1.93696228
133High anterior hairline (HP:0009890)1.93172126
134Triphalangeal thumb (HP:0001199)1.92828520
135Abnormality of iron homeostasis (HP:0011031)1.92172128
136Carpal bone hypoplasia (HP:0001498)1.91114045
137Neoplasm of striated muscle (HP:0009728)1.90635477
138Neoplasm of the colon (HP:0100273)1.90381879
139Diastasis recti (HP:0001540)1.88783543
140Abnormality of the gallbladder (HP:0005264)1.88523389
141Biliary tract neoplasm (HP:0100574)1.87589471
142Opisthotonus (HP:0002179)1.87039483
143Abnormal cartilage morphology (HP:0002763)1.86799766
144Nephritis (HP:0000123)1.86135863
145Abnormality of transition element cation homeostasis (HP:0011030)1.85785166
146Abnormality of chromosome segregation (HP:0002916)1.85689589
147Abnormal enzyme/coenzyme activity (HP:0012379)1.84479692
148Abnormality of the lower motor neuron (HP:0002366)1.84077166
149Elevated hepatic transaminases (HP:0002910)1.83925208
150Aqueductal stenosis (HP:0002410)1.83839442
151Pulmonary embolism (HP:0002204)1.83293459
152Rickets (HP:0002748)1.83072199
153Vomiting (HP:0002013)1.82548512
154Skull defect (HP:0001362)1.82377860
155Brushfield spots (HP:0001088)1.80683290
156Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79737316
157Missing ribs (HP:0000921)1.79173071
158Choanal atresia (HP:0000453)1.79128700
159Neoplasm of the small intestine (HP:0100833)1.78018054
160Cafe-au-lait spot (HP:0000957)1.77759285
161Late onset (HP:0003584)1.77026323
162Stenosis of the external auditory canal (HP:0000402)1.76840934
163Increased mean platelet volume (HP:0011877)1.75843519
164Transitional cell carcinoma of the bladder (HP:0006740)1.75434611
165Facial cleft (HP:0002006)1.74177136
166Upper motor neuron abnormality (HP:0002127)1.73997462
167Acute hepatic failure (HP:0006554)1.72861515
168Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71447875
169Long clavicles (HP:0000890)1.71248614
170Abnormality of proline metabolism (HP:0010907)1.69099864
171Hydroxyprolinuria (HP:0003080)1.69099864
172Selective tooth agenesis (HP:0001592)1.68415191
173Reticulocytosis (HP:0001923)1.68056846
174Neoplasm of the oral cavity (HP:0100649)1.67868591
175Absent eyebrow (HP:0002223)1.67706848
176Elevated alkaline phosphatase (HP:0003155)1.67329825
177Acute lymphatic leukemia (HP:0006721)1.65890320
178Breast carcinoma (HP:0003002)1.65185130
179Relative macrocephaly (HP:0004482)1.63426740
180Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.62822581
181Short humerus (HP:0005792)1.62784174
182Spinal cord lesions (HP:0100561)1.60739865
183Syringomyelia (HP:0003396)1.60739865
184Preaxial foot polydactyly (HP:0001841)1.59196325
185Uterine leiomyosarcoma (HP:0002891)1.59111013
186Leiomyosarcoma (HP:0100243)1.59111013
187Bladder neoplasm (HP:0009725)1.59108375
188Bladder carcinoma (HP:0002862)1.59108375
189Duplication of thumb phalanx (HP:0009942)1.58217086
190Abnormality of the antihelix (HP:0009738)1.57598038
191Shoulder girdle muscle weakness (HP:0003547)1.57428847
192Reduced antithrombin III activity (HP:0001976)1.56931482
193Hypoplastic labia majora (HP:0000059)1.56311417
194Small hand (HP:0200055)1.54542048
195Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54348609
196Short 4th metacarpal (HP:0010044)1.54348609
197Uterine neoplasm (HP:0010784)1.53514316
198Microglossia (HP:0000171)1.52957693
199Thyroid carcinoma (HP:0002890)1.52637263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.56313479
2FGFR44.38096785
3SIK14.13472190
4ERN13.78014680
5CDC73.45405982
6TTK3.31639760
7TAOK33.25093739
8ERBB43.02473919
9PNCK2.88087372
10TSSK62.85137156
11MKNK12.82006431
12MKNK22.81878933
13PBK2.80483768
14BUB12.73389556
15SRPK12.70735781
16TAF12.64325518
17PLK42.55666968
18PKN22.26554128
19INSRR2.20346676
20TYK22.20195470
21WEE12.10847895
22LATS12.09999445
23TNIK2.09055674
24PLK32.06211268
25BCR2.03245373
26BRSK22.00353611
27MAPK111.96231683
28FLT31.91834110
29MAP2K41.86957467
30ZAK1.81932899
31MST1R1.77538720
32NEK91.69832710
33EIF2AK31.63624304
34MAP3K101.58771278
35MAP3K141.58262134
36FRK1.55115477
37PTK61.54538404
38ABL21.52557145
39BRD41.50944104
40PLK11.50576904
41CDK61.46706877
42CHEK21.43545652
43FGFR21.42592963
44JAK21.42325573
45TRIB31.42017549
46PIK3CG1.41816801
47MAP2K31.39148121
48CSF1R1.37197601
49TRIM281.36828961
50KDR1.33664945
51FGFR31.32776485
52JAK11.30455991
53ATR1.27975023
54CDK191.25210395
55CAMK1D1.24935174
56NEK11.23417644
57ERBB21.22904374
58WNK31.22277701
59TGFBR21.18226742
60BMPR1B1.16918818
61TBK11.15153474
62PRKAA21.13360098
63GRK61.12461819
64CASK1.12182860
65CHEK11.11887256
66AKT31.11591496
67ATM1.09888774
68IKBKE1.07508231
69CLK11.07313123
70MAP3K71.06138080
71FGFR11.03046680
72MAPK41.02803520
73CDK71.00832411
74TAOK21.00695936
75SGK30.96322125
76AURKB0.95657972
77YES10.95420282
78NEK20.93891479
79TIE10.93047579
80ERBB30.91394609
81EIF2AK20.91154165
82MAP4K10.90859169
83EPHA30.90709685
84NUAK10.89332862
85NLK0.89222304
86VRK10.88975319
87CDK40.88558009
88MST40.86338073
89MELK0.85750654
90CSK0.83756357
91RPS6KB20.83298300
92DYRK30.82648032
93PDK20.82511504
94CDK30.81131721
95KIT0.80685806
96RPS6KA40.80278054
97SGK20.80064942
98RIPK10.79825232
99SCYL20.78730922
100STK160.76032779
101PASK0.76014762
102DAPK20.75009830
103JAK30.74434984
104IRAK30.73820916
105STK38L0.73115803
106MAP3K30.72254943
107PRKCZ0.70558401
108MAP3K60.68543553
109LATS20.67954129
110MAP2K60.66999945
111GSK3A0.66638756
112PRKAA10.66334880
113ALK0.66035466
114STK390.65888373
115MAP3K50.64823724
116STK30.64532205
117MAPK120.62411037
118DYRK1B0.62178735
119CAMK1G0.61519931
120CDK10.60948339
121CDK20.59744725
122PRKACG0.58782607
123PRKDC0.57430754
124IGF1R0.55151311
125EGFR0.54952541
126PRKCQ0.53574807
127CSNK1E0.53450141
128IKBKB0.51962681
129BTK0.51543855
130CHUK0.51384325
131STK240.50930356
132CDK90.50797907
133MAP3K40.50254747
134ITK0.49990964
135EPHB10.49830456
136EEF2K0.49767239
137ACVR1B0.49318124
138MAPK70.48588596
139PLK20.48176035
140BRSK10.46765054
141BRAF0.46242268
142PINK10.44854174
143CDK120.44816982
144CSNK1G10.44250603
145MTOR0.44099605
146KSR10.43356643
147PAK20.43261257
148ABL10.42103144
149STK40.41573386
150MET0.40824018
151EIF2AK10.37910837
152RET0.37899227
153WNK10.37622773
154TGFBR10.36527872
155CSNK2A20.34397566
156PIM10.34317034
157ZAP700.33870405
158STK100.31868165
159TEC0.31656828
160PTK20.31561175
161RPS6KB10.31503317
162CAMK40.31082693
163PDGFRA0.31001342
164MAPK30.28975308
165PDGFRB0.28823073
166MAP3K130.28663221
167GRK10.28643631
168OXSR10.28449464
169MAP3K80.27169346
170LYN0.27095969
171CSNK2A10.25204908
172MAPK100.25060911

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.78258927
2Non-homologous end-joining_Homo sapiens_hsa034504.60793388
3DNA replication_Homo sapiens_hsa030303.78958136
4Nitrogen metabolism_Homo sapiens_hsa009103.75664359
5Mismatch repair_Homo sapiens_hsa034303.54108706
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39234018
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38284207
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19250736
9Arginine biosynthesis_Homo sapiens_hsa002203.07951627
10RNA transport_Homo sapiens_hsa030133.04096292
11Cell cycle_Homo sapiens_hsa041103.01771414
12Complement and coagulation cascades_Homo sapiens_hsa046102.99519445
13Fanconi anemia pathway_Homo sapiens_hsa034602.79058948
14Homologous recombination_Homo sapiens_hsa034402.73365483
15Tryptophan metabolism_Homo sapiens_hsa003802.73115386
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62477542
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54794135
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53764024
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53542448
20Fatty acid degradation_Homo sapiens_hsa000712.46962297
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31696309
22Base excision repair_Homo sapiens_hsa034102.30105965
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24809696
24Spliceosome_Homo sapiens_hsa030402.13347911
25mRNA surveillance pathway_Homo sapiens_hsa030152.11580419
26Nucleotide excision repair_Homo sapiens_hsa034202.09793447
27Peroxisome_Homo sapiens_hsa041462.06835621
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04105329
29Basal transcription factors_Homo sapiens_hsa030222.02987320
30Butanoate metabolism_Homo sapiens_hsa006502.02435795
31Staphylococcus aureus infection_Homo sapiens_hsa051501.98661827
32Caffeine metabolism_Homo sapiens_hsa002321.95561219
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.92836536
34RNA degradation_Homo sapiens_hsa030181.89792563
35Histidine metabolism_Homo sapiens_hsa003401.89414613
36Chemical carcinogenesis_Homo sapiens_hsa052041.87365541
37PPAR signaling pathway_Homo sapiens_hsa033201.87314990
38Propanoate metabolism_Homo sapiens_hsa006401.84529679
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.83316849
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83254584
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73880921
42Fatty acid metabolism_Homo sapiens_hsa012121.73166092
43Selenocompound metabolism_Homo sapiens_hsa004501.71824063
44beta-Alanine metabolism_Homo sapiens_hsa004101.71231314
45Retinol metabolism_Homo sapiens_hsa008301.70870112
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69081179
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59626248
48Phenylalanine metabolism_Homo sapiens_hsa003601.52171428
49TGF-beta signaling pathway_Homo sapiens_hsa043501.50736416
50Bile secretion_Homo sapiens_hsa049761.47364174
51p53 signaling pathway_Homo sapiens_hsa041151.46672178
52Tyrosine metabolism_Homo sapiens_hsa003501.41739920
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38591313
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38319752
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.35207258
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32205889
57ABC transporters_Homo sapiens_hsa020101.31596176
58Adherens junction_Homo sapiens_hsa045201.30908934
59Starch and sucrose metabolism_Homo sapiens_hsa005001.27995397
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26717460
61Pyruvate metabolism_Homo sapiens_hsa006201.19920258
62Folate biosynthesis_Homo sapiens_hsa007901.19757345
63Biosynthesis of amino acids_Homo sapiens_hsa012301.15391567
64Basal cell carcinoma_Homo sapiens_hsa052171.14834109
65MicroRNAs in cancer_Homo sapiens_hsa052061.14714063
66Thyroid cancer_Homo sapiens_hsa052161.14600466
67Fatty acid elongation_Homo sapiens_hsa000621.13267609
68Sulfur metabolism_Homo sapiens_hsa009201.11672395
69Steroid biosynthesis_Homo sapiens_hsa001001.10594699
70RNA polymerase_Homo sapiens_hsa030201.09929318
71Fat digestion and absorption_Homo sapiens_hsa049751.08830657
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07942010
73Hedgehog signaling pathway_Homo sapiens_hsa043401.05787285
74Hippo signaling pathway_Homo sapiens_hsa043901.03543735
75Colorectal cancer_Homo sapiens_hsa052101.03262944
76Carbon metabolism_Homo sapiens_hsa012001.02248189
77Pyrimidine metabolism_Homo sapiens_hsa002401.02099754
78Small cell lung cancer_Homo sapiens_hsa052221.01383502
79Oocyte meiosis_Homo sapiens_hsa041141.01269208
80Lysine degradation_Homo sapiens_hsa003100.99797575
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98857685
82Proteasome_Homo sapiens_hsa030500.97836334
83Wnt signaling pathway_Homo sapiens_hsa043100.96913492
84One carbon pool by folate_Homo sapiens_hsa006700.96533407
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94786821
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91838779
87Vitamin B6 metabolism_Homo sapiens_hsa007500.90915929
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90467506
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.89672624
90Sulfur relay system_Homo sapiens_hsa041220.86168457
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.86109114
92Vitamin digestion and absorption_Homo sapiens_hsa049770.85624041
93Prostate cancer_Homo sapiens_hsa052150.84891736
94Protein export_Homo sapiens_hsa030600.84017906
95Arginine and proline metabolism_Homo sapiens_hsa003300.83151148
96Melanoma_Homo sapiens_hsa052180.79246941
97Chronic myeloid leukemia_Homo sapiens_hsa052200.76221521
98Purine metabolism_Homo sapiens_hsa002300.71950319
99N-Glycan biosynthesis_Homo sapiens_hsa005100.71464594
100Proteoglycans in cancer_Homo sapiens_hsa052050.69861437
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69595676
102ECM-receptor interaction_Homo sapiens_hsa045120.65151320
103Viral carcinogenesis_Homo sapiens_hsa052030.61863371
104Pathways in cancer_Homo sapiens_hsa052000.61149284
105Glycerolipid metabolism_Homo sapiens_hsa005610.61047058
106Tight junction_Homo sapiens_hsa045300.57408599
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57189381
108Glutathione metabolism_Homo sapiens_hsa004800.56789777
109Pentose phosphate pathway_Homo sapiens_hsa000300.54481964
110Pancreatic cancer_Homo sapiens_hsa052120.53381942
111Fatty acid biosynthesis_Homo sapiens_hsa000610.51927407
112HTLV-I infection_Homo sapiens_hsa051660.45060501
113Alcoholism_Homo sapiens_hsa050340.44271996
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42164446
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41438561
116Prion diseases_Homo sapiens_hsa050200.38870650
117Focal adhesion_Homo sapiens_hsa045100.38194142
118Metabolic pathways_Homo sapiens_hsa011000.37839054
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37009171
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34723819
121Endometrial cancer_Homo sapiens_hsa052130.33374661
122Insulin resistance_Homo sapiens_hsa049310.31128369
123Dorso-ventral axis formation_Homo sapiens_hsa043200.27465131
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.26277114
125Axon guidance_Homo sapiens_hsa043600.25387179
126Bladder cancer_Homo sapiens_hsa052190.25248137
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24741371
128Epstein-Barr virus infection_Homo sapiens_hsa051690.24036857
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22941920
130Ribosome_Homo sapiens_hsa030100.20725035
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18145323
132Galactose metabolism_Homo sapiens_hsa000520.17579063
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15580006
134Glioma_Homo sapiens_hsa052140.14508627
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14439478
136Hepatitis B_Homo sapiens_hsa051610.13196688
137Herpes simplex infection_Homo sapiens_hsa051680.13025209
138Systemic lupus erythematosus_Homo sapiens_hsa053220.11825341
139Linoleic acid metabolism_Homo sapiens_hsa005910.11695472
140Fructose and mannose metabolism_Homo sapiens_hsa000510.11097728
141Glucagon signaling pathway_Homo sapiens_hsa049220.06751519
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.05533321
143AMPK signaling pathway_Homo sapiens_hsa041520.03849631
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.00822686
145Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2249336
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2238335
147Regulation of autophagy_Homo sapiens_hsa04140-0.2078288
148Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1978907
149Legionellosis_Homo sapiens_hsa05134-0.1819849
150Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1816547
151Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1812889
152Malaria_Homo sapiens_hsa05144-0.1714169
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1700795
154Amoebiasis_Homo sapiens_hsa05146-0.1695083
155Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1637279
156Renin-angiotensin system_Homo sapiens_hsa04614-0.1626803
157NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1533717
158Pertussis_Homo sapiens_hsa05133-0.1365790
159Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1324263
160African trypanosomiasis_Homo sapiens_hsa05143-0.1035221
161Insulin signaling pathway_Homo sapiens_hsa04910-0.1010517
162Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0950950
163Hepatitis C_Homo sapiens_hsa05160-0.0681043
164Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0030749

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