ATP12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H+/K+ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for potassium absorption in various tissues. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.32627372
2diterpenoid biosynthetic process (GO:0016102)9.25420261
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060529.10006374
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.95981314
5fucose catabolic process (GO:0019317)8.73851261
6L-fucose metabolic process (GO:0042354)8.73851261
7L-fucose catabolic process (GO:0042355)8.73851261
8primary alcohol catabolic process (GO:0034310)7.18819949
9axoneme assembly (GO:0035082)6.96303749
10multicellular organismal water homeostasis (GO:0050891)6.88358049
11prostate gland epithelium morphogenesis (GO:0060740)6.83396200
12terpenoid biosynthetic process (GO:0016114)6.54106312
13left/right pattern formation (GO:0060972)6.45591396
14mannose metabolic process (GO:0006013)6.43696653
15intestinal epithelial cell development (GO:0060576)6.39460062
16artery development (GO:0060840)6.23252107
17hemidesmosome assembly (GO:0031581)6.19371352
18regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.11598893
19COPI coating of Golgi vesicle (GO:0048205)6.07372110
20Golgi transport vesicle coating (GO:0048200)6.07372110
21fucose metabolic process (GO:0006004)6.03309559
22galactose catabolic process (GO:0019388)5.86218324
23UDP-N-acetylglucosamine metabolic process (GO:0006047)5.82722900
24N-glycan processing (GO:0006491)5.76919135
25ethanol metabolic process (GO:0006067)5.73646946
26water homeostasis (GO:0030104)5.73623524
27retinoic acid metabolic process (GO:0042573)5.66444537
28one-carbon compound transport (GO:0019755)5.59349906
29keratinocyte differentiation (GO:0030216)5.57733520
30establishment of planar polarity (GO:0001736)5.04744367
31establishment of tissue polarity (GO:0007164)5.04744367
32mitotic cell cycle arrest (GO:0071850)5.01545429
33response to testosterone (GO:0033574)4.96712919
34retinol metabolic process (GO:0042572)4.91373615
35regulation of receptor binding (GO:1900120)4.89050355
36vitamin transmembrane transport (GO:0035461)4.86269340
37epithelial cell differentiation involved in prostate gland development (GO:0060742)4.85004762
38epithelial cell maturation (GO:0002070)4.83782115
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.80218862
40pyrimidine-containing compound transmembrane transport (GO:0072531)4.78992188
41left/right axis specification (GO:0070986)4.77262032
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75802845
43desmosome organization (GO:0002934)4.70972894
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.69164148
45lung secretory cell differentiation (GO:0061140)4.69120995
46microtubule bundle formation (GO:0001578)4.57912809
47regulation of cilium movement (GO:0003352)4.55153362
48keratinocyte proliferation (GO:0043616)4.54906387
49sulfur amino acid catabolic process (GO:0000098)4.49907597
50protein autoprocessing (GO:0016540)4.48426080
51ventricular system development (GO:0021591)4.48311435
52ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.48241604
53positive regulation of nuclease activity (GO:0032075)4.47241984
54establishment of apical/basal cell polarity (GO:0035089)4.47003074
55epidermal cell differentiation (GO:0009913)4.46056323
56glomerular epithelial cell development (GO:0072310)4.44733721
57epidermis development (GO:0008544)4.44115766
58lung epithelium development (GO:0060428)4.41809931
59positive regulation of steroid hormone secretion (GO:2000833)4.38568277
60hormone catabolic process (GO:0042447)4.30069403
61lipoxygenase pathway (GO:0019372)4.29442699
62fucosylation (GO:0036065)4.28199766
63peptide cross-linking (GO:0018149)4.24296264
64long-chain fatty acid biosynthetic process (GO:0042759)4.20136399
65ethanol oxidation (GO:0006069)4.19573966
66nucleotide-sugar biosynthetic process (GO:0009226)4.12447419
67primary alcohol metabolic process (GO:0034308)4.09647121
68gap junction assembly (GO:0016264)4.09376225
69valine metabolic process (GO:0006573)4.07264526
70regulation of nuclease activity (GO:0032069)4.03333748
71hexose catabolic process (GO:0019320)3.99473677
72GDP-mannose metabolic process (GO:0019673)3.96662090
73endoplasmic reticulum unfolded protein response (GO:0030968)3.89017424
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.81371998
75protein retention in ER lumen (GO:0006621)3.78275565
76response to xenobiotic stimulus (GO:0009410)3.76664465
77positive regulation of growth hormone secretion (GO:0060124)3.75780338
78intraciliary transport (GO:0042073)3.75017754
79cellular response to unfolded protein (GO:0034620)3.74392699
80centriole assembly (GO:0098534)3.72521544
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72254615
82cilium organization (GO:0044782)3.72028398
83O-glycan processing (GO:0016266)3.71265344
84surfactant homeostasis (GO:0043129)3.70366241
85establishment of monopolar cell polarity (GO:0061162)3.69307169
86establishment or maintenance of monopolar cell polarity (GO:0061339)3.69307169
87activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.68014242
88galactose metabolic process (GO:0006012)3.64325505
89positive regulation of catenin import into nucleus (GO:0035413)3.64241058
90regulation of water loss via skin (GO:0033561)3.61519422
91molting cycle (GO:0042303)3.61440216
92hair cycle (GO:0042633)3.61440216
93cilium assembly (GO:0042384)3.61278902
94positive regulation of natural killer cell differentiation (GO:0032825)3.59292327
95ER-nucleus signaling pathway (GO:0006984)3.59001958
96nucleotide-sugar metabolic process (GO:0009225)3.56980156
97transcytosis (GO:0045056)3.56652038
98glandular epithelial cell differentiation (GO:0002067)3.55770860
99tolerance induction (GO:0002507)3.55436368
100calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.55334980
101response to endoplasmic reticulum stress (GO:0034976)3.54748441
102negative regulation of T cell differentiation in thymus (GO:0033085)3.54433038
103lateral sprouting from an epithelium (GO:0060601)3.53119713
104apoptotic cell clearance (GO:0043277)3.52626670
105intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.51511230
106pharyngeal system development (GO:0060037)3.49580828
107phosphatidylserine acyl-chain remodeling (GO:0036150)3.45215855
108cellular response to topologically incorrect protein (GO:0035967)3.43932479
109sperm capacitation (GO:0048240)3.39449368
110protein N-linked glycosylation via asparagine (GO:0018279)3.36634037
111peptidyl-asparagine modification (GO:0018196)3.36190194
112creatine metabolic process (GO:0006600)3.33631653
113anterior/posterior axis specification, embryo (GO:0008595)3.31327421
114COPII vesicle coating (GO:0048208)3.29599989
115interferon-gamma secretion (GO:0072643)3.29336235
116chemical homeostasis within a tissue (GO:0048875)3.28478961
117regulation of interleukin-5 production (GO:0032674)3.25490956
118establishment of skin barrier (GO:0061436)3.23250147
119progesterone metabolic process (GO:0042448)3.19731139
120monosaccharide catabolic process (GO:0046365)3.18311418
121oligosaccharide biosynthetic process (GO:0009312)3.15081413
122retinal metabolic process (GO:0042574)3.14015671
123negative regulation of cholesterol transport (GO:0032375)3.11921619
124negative regulation of sterol transport (GO:0032372)3.11921619
125hypotonic response (GO:0006971)3.09569481
126protein N-linked glycosylation (GO:0006487)3.06545289
127positive regulation of tolerance induction (GO:0002645)3.04414595
128intermediate filament organization (GO:0045109)3.03623651
129epithelial cell-cell adhesion (GO:0090136)3.00716101
130regulation of growth hormone secretion (GO:0060123)2.98128082
131maintenance of gastrointestinal epithelium (GO:0030277)2.96559958
132response to unfolded protein (GO:0006986)2.95518247
133microtubule-based movement (GO:0007018)2.95214255
134embryonic camera-type eye development (GO:0031076)2.95177417
135apical protein localization (GO:0045176)2.93248822
136sequestering of metal ion (GO:0051238)2.92021165
137negative regulation of humoral immune response (GO:0002921)2.91666972
138regulation of interleukin-13 production (GO:0032656)2.91525008
139positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.91373666
140regulation of steroid hormone secretion (GO:2000831)2.90728559
141keratinization (GO:0031424)2.90093300
142cell projection assembly (GO:0030031)2.87534884
143excretion (GO:0007588)2.87529572
144cytoplasmic microtubule organization (GO:0031122)2.87376606
145L-serine transport (GO:0015825)2.86133908
146zinc ion transport (GO:0006829)2.85800146
147regulation of viral entry into host cell (GO:0046596)2.85164961
148regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.85058020
149vesicle coating (GO:0006901)2.84504812
150regulation of natural killer cell differentiation (GO:0032823)2.84485084
151negative regulation of erythrocyte differentiation (GO:0045647)2.82864573
152cellular modified amino acid catabolic process (GO:0042219)2.82822745
153cGMP-mediated signaling (GO:0019934)2.82815985
154regulation of axon regeneration (GO:0048679)2.82661642
155regulation of neuron projection regeneration (GO:0070570)2.82661642
156dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82099029
157cellular component assembly involved in morphogenesis (GO:0010927)2.80500948
158polyol transport (GO:0015791)2.80127337
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.79568389
160ectodermal placode formation (GO:0060788)2.78673107
161negative regulation of interferon-gamma production (GO:0032689)2.78515533
162negative regulation of B cell mediated immunity (GO:0002713)2.76615416
163negative regulation of immunoglobulin mediated immune response (GO:0002890)2.76615416
1642-oxoglutarate metabolic process (GO:0006103)2.75030726
165linoleic acid metabolic process (GO:0043651)2.74621441
166positive regulation of actin filament depolymerization (GO:0030836)2.74242575
167response to topologically incorrect protein (GO:0035966)2.74101838
168protein targeting to Golgi (GO:0000042)2.73143545
169phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.73040034
170lung cell differentiation (GO:0060479)2.71784549
171phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.70751450
172protein localization to cilium (GO:0061512)2.67309619
173exogenous drug catabolic process (GO:0042738)2.66809463
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.65517386
175ear development (GO:0043583)2.63216740
176renal absorption (GO:0070293)2.61591341
177regulation of transforming growth factor beta1 production (GO:0032908)2.59252178
178regulation of germinal center formation (GO:0002634)2.58401152
179carnitine metabolic process (GO:0009437)2.58052290
180phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.55010074
181establishment or maintenance of apical/basal cell polarity (GO:0035088)2.54499217
182axonemal dynein complex assembly (GO:0070286)15.9405823
183cilium or flagellum-dependent cell motility (GO:0001539)12.3301193
184branching involved in prostate gland morphogenesis (GO:0060442)11.2475829
185cilium movement (GO:0003341)10.8701399
186motile cilium assembly (GO:0044458)10.8649391

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.96387464
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.88875994
3ZNF263_19887448_ChIP-Seq_K562_Human3.54804184
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.43278049
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.11376096
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.05631964
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.99616316
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.73195167
9SOX2_20726797_ChIP-Seq_SW620_Human2.71509552
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69369895
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69369895
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69369895
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.67033755
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.58962877
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56678673
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48815424
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.44631395
18GATA6_25053715_ChIP-Seq_YYC3_Human2.40434378
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.38985721
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.35587930
21GATA4_25053715_ChIP-Seq_YYC3_Human2.29127336
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24050232
23CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20121406
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.16813105
25AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.16779325
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.09943408
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.09943408
28ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06565702
29TP63_23658742_ChIP-Seq_EP156T_Human2.02760957
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.00706012
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.99448463
32CLOCK_20551151_ChIP-Seq_293T_Human1.87836948
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.86549758
34RACK7_27058665_Chip-Seq_MCF-7_Human1.82052816
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81762244
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78446368
37* SMAD3_21741376_ChIP-Seq_HESCs_Human1.75535260
38ATF3_27146783_Chip-Seq_COLON_Human1.73802847
39ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.66655605
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65425996
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64580007
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61665732
43KLF5_25053715_ChIP-Seq_YYC3_Human1.58551598
44AHR_22903824_ChIP-Seq_MCF-7_Human1.57440443
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.57040726
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53368119
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.49543323
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.46717188
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46012321
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44438748
51CHD1_26751641_Chip-Seq_LNCaP_Human1.42471104
52CREB1_26743006_Chip-Seq_LNCaP_Human1.41089909
53AR_21909140_ChIP-Seq_LNCAP_Human1.40610336
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38781406
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37556951
56FOXA1_25552417_ChIP-Seq_VCAP_Human1.34182335
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33897651
58SMC4_20622854_ChIP-Seq_HELA_Human1.32781391
59* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32753547
60* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32169201
61TP53_18474530_ChIP-ChIP_U2OS_Human1.28953760
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26044319
63DROSHA_22980978_ChIP-Seq_HELA_Human1.24797257
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.23496522
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23260980
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.22466898
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16711412
68FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14889848
69FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13895826
70CTCF_27219007_Chip-Seq_Bcells_Human1.11911905
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10560195
72ELF5_23300383_ChIP-Seq_T47D_Human1.08435090
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08406442
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08000162
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06888796
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.06481451
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06107949
78GATA1_19941826_ChIP-Seq_K562_Human1.05978224
79* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04979198
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04254700
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03858053
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.02722122
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.01243721
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00590678
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00590678
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99896933
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98561521
88* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98149528
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97306324
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97214046
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97203438
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.96133190
93CJUN_26792858_Chip-Seq_BT549_Human0.95690051
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94255329
95CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94092804
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93313453
97TP53_22127205_ChIP-Seq_IMR90_Human0.92788252
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92691502
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92363154
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92011985
101RBPJ_21746931_ChIP-Seq_IB4_Human0.89576201
102HNFA_21074721_ChIP-Seq_CACO-2_Human0.88675239
103* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88523142
104CTCF_20526341_ChIP-Seq_ESCs_Human0.88207624
105* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87875048
106PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87400685
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87087677
108ETV1_20927104_ChIP-Seq_GIST48_Human0.86865025
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84860466
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.84292435
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83525334
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82630683
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82264276
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.82076565
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80651215
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80216645
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80059860
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78812568
119CEBPB_22108803_ChIP-Seq_LS180_Human0.78601923
120PHF8_20622853_ChIP-Seq_HELA_Human0.78342447
121GATA2_19941826_ChIP-Seq_K562_Human0.77684972
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76873605
123RXR_22108803_ChIP-Seq_LS180_Human0.76717594
124LXR_22292898_ChIP-Seq_THP-1_Human0.76715193
125STAT1_20625510_ChIP-Seq_HELA_Human0.76697143
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76192404
127CBX2_22325352_ChIP-Seq_293T-Rex_Human0.75714642
128CDX2_22108803_ChIP-Seq_LS180_Human0.75327393
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75199932
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.75188364
131TP63_22573176_ChIP-Seq_HFKS_Human0.74877396
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74822695
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74731432
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.74307933
135ELF1_20517297_ChIP-Seq_JURKAT_Human0.73926965
136TCF4_18268006_ChIP-ChIP_LS174T_Human0.72688641
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70862543
138PHF8_20622854_ChIP-Seq_HELA_Human0.70384417
139* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.70307265
140P68_20966046_ChIP-Seq_HELA_Human0.70236175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.91107408
2MP0005310_abnormal_salivary_gland4.09585907
3MP0002166_altered_tumor_susceptibility3.71225773
4MP0000537_abnormal_urethra_morphology3.64872510
5MP0003300_gastrointestinal_ulcer3.52090749
6MP0004264_abnormal_extraembryonic_tissu3.40713589
7MP0003705_abnormal_hypodermis_morpholog3.20614159
8MP0003878_abnormal_ear_physiology3.12299624
9MP0005377_hearing/vestibular/ear_phenot3.12299624
10MP0005647_abnormal_sex_gland2.93864039
11MP0004043_abnormal_pH_regulation2.89701743
12MP0002006_tumorigenesis2.85509300
13MP0004133_heterotaxia2.77884655
14MP0002796_impaired_skin_barrier2.73153246
15MP0003866_abnormal_defecation2.59713228
16MP0000613_abnormal_salivary_gland2.55452905
17MP0001873_stomach_inflammation2.53983975
18MP0005275_abnormal_skin_tensile2.46161041
19MP0010352_gastrointestinal_tract_polyps2.44932704
20MP0010678_abnormal_skin_adnexa2.31498932
21MP0003283_abnormal_digestive_organ2.30215023
22MP0002653_abnormal_ependyma_morphology2.27821750
23MP0001756_abnormal_urination2.01322391
24* MP0001765_abnormal_ion_homeostasis2.01083518
25MP0010030_abnormal_orbit_morphology2.00665172
26MP0000579_abnormal_nail_morphology2.00328804
27MP0001984_abnormal_olfaction1.98987840
28MP0005394_taste/olfaction_phenotype1.98609644
29MP0005499_abnormal_olfactory_system1.98609644
30MP0008789_abnormal_olfactory_epithelium1.95096875
31MP0004885_abnormal_endolymph1.85770400
32MP0002098_abnormal_vibrissa_morphology1.76739151
33MP0006054_spinal_hemorrhage1.75784854
34MP0000538_abnormal_urinary_bladder1.72996550
35MP0010386_abnormal_urinary_bladder1.72603789
36MP0000462_abnormal_digestive_system1.70731770
37MP0002277_abnormal_respiratory_mucosa1.70108080
38MP0002060_abnormal_skin_morphology1.67286516
39MP0005501_abnormal_skin_physiology1.66398122
40MP0002876_abnormal_thyroid_physiology1.65484696
41MP0010155_abnormal_intestine_physiology1.64323598
42MP0005623_abnormal_meninges_morphology1.56143044
43MP0005083_abnormal_biliary_tract1.55437258
44MP0001216_abnormal_epidermal_layer1.55389738
45MP0004381_abnormal_hair_follicle1.55370560
46MP0005409_darkened_coat_color1.52938458
47MP0002132_abnormal_respiratory_system1.51484073
48MP0005367_renal/urinary_system_phenotyp1.50685331
49MP0000516_abnormal_urinary_system1.50685331
50MP0003315_abnormal_perineum_morphology1.49859228
51MP0003890_abnormal_embryonic-extraembry1.45685955
52MP0003191_abnormal_cellular_cholesterol1.45442054
53MP0009379_abnormal_foot_pigmentation1.44353145
54MP0003566_abnormal_cell_adhesion1.43286472
55MP0009764_decreased_sensitivity_to1.39130032
56MP0000465_gastrointestinal_hemorrhage1.38262841
57MP0003453_abnormal_keratinocyte_physiol1.37790493
58MP0002009_preneoplasia1.37312436
59MP0000377_abnormal_hair_follicle1.36987240
60MP0001188_hyperpigmentation1.36676400
61MP0005187_abnormal_penis_morphology1.36588744
62MP0005381_digestive/alimentary_phenotyp1.35997506
63MP0004947_skin_inflammation1.33387222
64MP0004019_abnormal_vitamin_homeostasis1.32152506
65MP0008004_abnormal_stomach_pH1.30808383
66MP0005248_abnormal_Harderian_gland1.30714778
67MP0009643_abnormal_urine_homeostasis1.30339874
68MP0001663_abnormal_digestive_system1.29978061
69MP0000762_abnormal_tongue_morphology1.27833160
70MP0005023_abnormal_wound_healing1.27383244
71MP0000477_abnormal_intestine_morphology1.26733275
72MP0000467_abnormal_esophagus_morphology1.21456041
73MP0000383_abnormal_hair_follicle1.20646660
74MP0005166_decreased_susceptibility_to1.19856265
75MP0002233_abnormal_nose_morphology1.16979787
76MP0000490_abnormal_crypts_of1.16931482
77MP0001849_ear_inflammation1.16043796
78* MP0005636_abnormal_mineral_homeostasis1.15051278
79MP0005058_abnormal_lysosome_morphology1.12173177
80MP0001666_abnormal_nutrient_absorption1.11200327
81MP0000678_abnormal_parathyroid_gland1.09922921
82MP0002295_abnormal_pulmonary_circulatio1.09089838
83MP0001664_abnormal_digestion1.08639589
84MP0010771_integument_phenotype1.08097697
85MP0008438_abnormal_cutaneous_collagen1.08070488
86MP0000647_abnormal_sebaceous_gland1.07156712
87MP0000627_abnormal_mammary_gland1.03727634
88MP0003656_abnormal_erythrocyte_physiolo1.02889228
89MP0009384_cardiac_valve_regurgitation1.02110199
90MP0005076_abnormal_cell_differentiation0.99072416
91MP0005257_abnormal_intraocular_pressure0.97791912
92MP0003183_abnormal_peptide_metabolism0.96803038
93MP0002909_abnormal_adrenal_gland0.96147940
94MP0001346_abnormal_lacrimal_gland0.96091108
95MP0003045_fibrosis0.94743832
96MP0000427_abnormal_hair_cycle0.94446071
97MP0000534_abnormal_ureter_morphology0.94236003
98MP0000470_abnormal_stomach_morphology0.92796157
99MP0009765_abnormal_xenobiotic_induced0.92196126
100MP0003136_yellow_coat_color0.92027817
101MP0002282_abnormal_trachea_morphology0.91831306
102MP0004782_abnormal_surfactant_physiolog0.91326282
103* MP0002136_abnormal_kidney_physiology0.90869521
104MP0002896_abnormal_bone_mineralization0.90555144
105MP0009053_abnormal_anal_canal0.84720178
106MP0003941_abnormal_skin_development0.82812800
107MP0005220_abnormal_exocrine_pancreas0.81426462
108MP0004858_abnormal_nervous_system0.80875728
109MP0005332_abnormal_amino_acid0.80471071
110MP0002139_abnormal_hepatobiliary_system0.79792896
111MP0000858_altered_metastatic_potential0.79740147
112MP0009780_abnormal_chondrocyte_physiolo0.76436466
113MP0002254_reproductive_system_inflammat0.76408860
114MP0003936_abnormal_reproductive_system0.74529171
115MP0001485_abnormal_pinna_reflex0.74208856
116MP0005319_abnormal_enzyme/_coenzyme0.73199899
117MP0002111_abnormal_tail_morphology0.71420477
118MP0003868_abnormal_feces_composition0.71078125
119MP0005165_increased_susceptibility_to0.70912250
120MP0004272_abnormal_basement_membrane0.70908135
121MP0001881_abnormal_mammary_gland0.70529137
122MP0002168_other_aberrant_phenotype0.70271715
123MP0003119_abnormal_digestive_system0.69852909
124MP0009931_abnormal_skin_appearance0.69695211
125MP0004185_abnormal_adipocyte_glucose0.67244256
126MP0002084_abnormal_developmental_patter0.61184605
127MP0003937_abnormal_limbs/digits/tail_de0.60011935
128MP0003075_altered_response_to0.59208272
129MP0000681_abnormal_thyroid_gland0.58709373
130MP0000566_synostosis0.58375577
131MP0003638_abnormal_response/metabolism_0.58058202
132MP0005164_abnormal_response_to0.57705976
133MP0001299_abnormal_eye_distance/0.57500730
134MP0002160_abnormal_reproductive_system0.57181603
135MP0000343_altered_response_to0.57063392
136MP0000428_abnormal_craniofacial_morphol0.56114143
137MP0000367_abnormal_coat/_hair0.55368097
138MP0008875_abnormal_xenobiotic_pharmacok0.55141345
139MP0002249_abnormal_larynx_morphology0.55032142
140MP0001191_abnormal_skin_condition0.54623801
141MP0003950_abnormal_plasma_membrane0.51339874
142MP0001784_abnormal_fluid_regulation0.47526466
143MP0001851_eye_inflammation0.46992856
144MP0002133_abnormal_respiratory_system0.46540717
145MP0005388_respiratory_system_phenotype0.46540717
146MP0008260_abnormal_autophagy0.45815311
147MP0005395_other_phenotype0.42870372
148MP0003828_pulmonary_edema0.42314995
149MP0001243_abnormal_dermal_layer0.34372543

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.22278124
2Abnormal respiratory epithelium morphology (HP:0012253)9.22278124
3Abnormal respiratory motile cilium physiology (HP:0012261)9.19843700
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.88431897
5Absent/shortened dynein arms (HP:0200106)8.88431897
6Rhinitis (HP:0012384)8.83570003
7Abnormal ciliary motility (HP:0012262)8.73635436
8Chronic bronchitis (HP:0004469)7.81750339
9Bronchiectasis (HP:0002110)6.39426945
10Right ventricular cardiomyopathy (HP:0011663)5.91358762
11Nasal polyposis (HP:0100582)5.71407798
12Onycholysis (HP:0001806)5.61405039
13Abnormality of cochlea (HP:0000375)5.25793073
14Milia (HP:0001056)4.91081349
15Abnormality of the nasal mucosa (HP:0000433)4.66036477
16Atrophic scars (HP:0001075)4.49228272
17Fragile nails (HP:0001808)4.41714059
18Pili torti (HP:0003777)4.08597794
19Aortic aneurysm (HP:0004942)3.93999047
20Bronchitis (HP:0012387)3.85331423
21Woolly hair (HP:0002224)3.77278161
22Vacuolated lymphocytes (HP:0001922)3.77112209
23Plantar hyperkeratosis (HP:0007556)3.64129179
24Infertility (HP:0000789)3.57300776
25Hyperactive renin-angiotensin system (HP:0000841)3.48027750
26Morphological abnormality of the inner ear (HP:0011390)3.46801481
27Recurrent sinusitis (HP:0011108)3.45964078
28Recurrent otitis media (HP:0000403)3.40982296
29Myopathic facies (HP:0002058)3.38656076
30Erythroderma (HP:0001019)3.25270285
31Congenital ichthyosiform erythroderma (HP:0007431)3.20176376
32Oral leukoplakia (HP:0002745)3.14879568
33Abnormal tarsal ossification (HP:0008369)3.12806751
34Shawl scrotum (HP:0000049)3.11182908
35Increased IgE level (HP:0003212)3.10774186
36Chronic sinusitis (HP:0011109)3.06157113
37Abnormal foot bone ossification (HP:0010675)3.05733918
38Aortic dissection (HP:0002647)2.98614490
39Ureteral stenosis (HP:0000071)2.96930864
40Ileus (HP:0002595)2.91700995
41Nail dystrophy (HP:0008404)2.89671034
42Abdominal distention (HP:0003270)2.87123755
43Abnormality of the 2nd finger (HP:0004100)2.84495312
44Rectal prolapse (HP:0002035)2.77648179
45Corneal erosion (HP:0200020)2.77008420
46Erythema (HP:0010783)2.76223300
47Abnormal hair laboratory examination (HP:0003328)2.75601122
48Ureteral obstruction (HP:0006000)2.75088157
49Abnormality of the intrinsic pathway (HP:0010989)2.74690506
50Curly hair (HP:0002212)2.70923512
51Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.70734891
52Mildly elevated creatine phosphokinase (HP:0008180)2.69388265
53Occipital encephalocele (HP:0002085)2.69293672
54Biliary tract neoplasm (HP:0100574)2.57114911
55Abnormality of the 1st metacarpal (HP:0010009)2.55440231
56Abnormality of the axillary hair (HP:0100134)2.54856758
57Abnormality of secondary sexual hair (HP:0009888)2.54856758
58Lip pit (HP:0100267)2.53821076
59Abnormality of chloride homeostasis (HP:0011422)2.52243008
60Furrowed tongue (HP:0000221)2.51704393
61Absent eyelashes (HP:0000561)2.51148406
62Hypoplasia of the pons (HP:0012110)2.49651143
63Chronic otitis media (HP:0000389)2.49540228
64Malnutrition (HP:0004395)2.46241666
65Potter facies (HP:0002009)2.44080818
66Facial shape deformation (HP:0011334)2.44080818
67Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.42608223
68Short 1st metacarpal (HP:0010034)2.42608223
69Hypoplastic nipples (HP:0002557)2.41766754
70Atelectasis (HP:0100750)2.39516730
71Micronodular cirrhosis (HP:0001413)2.33361514
72Renal salt wasting (HP:0000127)2.31040311
73Short hallux (HP:0010109)2.29459518
74Hyperkalemia (HP:0002153)2.25872116
75Aplastic anemia (HP:0001915)2.21894106
76Subcapsular cataract (HP:0000523)2.21845652
77Facial diplegia (HP:0001349)2.21633590
78Abnormality of the pons (HP:0007361)2.20691898
79Widely patent fontanelles and sutures (HP:0004492)2.19332229
80Aplasia/Hypoplasia of the hallux (HP:0008362)2.18472182
81Achilles tendon contracture (HP:0001771)2.18201787
82Popliteal pterygium (HP:0009756)2.16517606
83Hand muscle atrophy (HP:0009130)2.16342396
84Pustule (HP:0200039)2.16100870
85Septate vagina (HP:0001153)2.14719213
86Abnormality of the distal phalanges of the toes (HP:0010182)2.14046896
87Parakeratosis (HP:0001036)2.12732304
88True hermaphroditism (HP:0010459)2.10841613
89Hypomagnesemia (HP:0002917)2.09179101
90Symphalangism affecting the phalanges of the hand (HP:0009773)2.08992960
91Sparse eyelashes (HP:0000653)2.07581614
92Hyporeflexia of lower limbs (HP:0002600)2.07184835
93Absent hair (HP:0002298)2.07168459
94Blepharitis (HP:0000498)2.05782909
95Sparse lateral eyebrow (HP:0005338)2.05473751
96Pancreatic fibrosis (HP:0100732)2.05230128
97Flat acetabular roof (HP:0003180)2.04218317
98Hypoplasia of the uterus (HP:0000013)2.04143632
99Palmoplantar hyperkeratosis (HP:0000972)2.03791430
100Abnormality of the dental root (HP:0006486)2.03729309
101Taurodontia (HP:0000679)2.03729309
102Abnormality of permanent molar morphology (HP:0011071)2.03729309
103Dysostosis multiplex (HP:0000943)2.03275227
104Decreased circulating renin level (HP:0003351)2.01653230
105Metabolic alkalosis (HP:0200114)2.00710018
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8098311
107Alopecia of scalp (HP:0002293)1.99652764
108Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.98861196
109Dehydration (HP:0001944)1.97398793
110Abnormality of the Achilles tendon (HP:0005109)1.97068194
111Hypoplasia of dental enamel (HP:0006297)1.96668342
112Abnormality of nail color (HP:0100643)1.95676617
113Gastrointestinal dysmotility (HP:0002579)1.95451207
114Aplasia of the musculature (HP:0100854)1.95449657
115Aplasia involving bones of the extremities (HP:0009825)1.95167726
116Aplasia involving bones of the upper limbs (HP:0009823)1.95167726
117Aplasia of the phalanges of the hand (HP:0009802)1.95167726
118Thick nail (HP:0001805)1.93971427
119Upper limb amyotrophy (HP:0009129)1.93747755
120Distal upper limb amyotrophy (HP:0007149)1.93747755
121Hypotrichosis (HP:0001006)1.93221166
122Abnormality of magnesium homeostasis (HP:0004921)1.91640705
123Fragile skin (HP:0001030)1.91346830
124Hyperaldosteronism (HP:0000859)1.90582682
125Aneurysm (HP:0002617)1.89510689
126Thrombocytosis (HP:0001894)1.88058130
127Back pain (HP:0003418)1.87282509
128Abnormality of the dental pulp (HP:0006479)1.86685273
129Abnormality of molar morphology (HP:0011070)1.86361121
130Abnormality of molar (HP:0011077)1.86361121
131Recurrent corneal erosions (HP:0000495)1.85414458
132Abnormality of the musculature of the hand (HP:0001421)1.85336512
133Hypoplastic labia majora (HP:0000059)1.85057844
134Breast hypoplasia (HP:0003187)1.84283555
135Palmar hyperkeratosis (HP:0010765)1.83584108
136Amelogenesis imperfecta (HP:0000705)1.83363940
137Hyperglycinuria (HP:0003108)1.83338938
138Abnormality of the salivary glands (HP:0010286)1.82750906
139Hydroxyprolinuria (HP:0003080)1.82443583
140Abnormality of proline metabolism (HP:0010907)1.82443583
141Hypohidrosis (HP:0000966)1.82249955
142Cone-rod dystrophy (HP:0000548)1.79753637
143Long toe (HP:0010511)1.78439257
144Male infertility (HP:0003251)1.77560619
145Absent phalangeal crease (HP:0006109)1.77202010
146Bell-shaped thorax (HP:0001591)1.75236627
147Short clavicles (HP:0000894)1.75186019
148Short humerus (HP:0005792)1.75155925
149Palmoplantar keratoderma (HP:0000982)1.74408828
150Congenital, generalized hypertrichosis (HP:0004540)1.74268721
151Abnormality of the labia majora (HP:0012881)1.74137918
152Ulnar deviation of finger (HP:0009465)1.73932828
153Cystic liver disease (HP:0006706)1.72794176
154Abnormal blistering of the skin (HP:0008066)1.71386969
155Abnormality of renin-angiotensin system (HP:0000847)1.69450271
156Conjunctival hamartoma (HP:0100780)1.65359450
157Chronic hepatic failure (HP:0100626)1.65106826
158Tubulointerstitial nephritis (HP:0001970)1.61680638
159Brittle hair (HP:0002299)1.60420891
160Asplenia (HP:0001746)1.58383142
161Pancreatic cysts (HP:0001737)1.57382106
162Aplasia/Hypoplasia of the spleen (HP:0010451)1.51647617
163Labial hypoplasia (HP:0000066)1.51366372
164Gangrene (HP:0100758)1.51039125
165Abnormality of monocarboxylic acid metabolism (HP:0010996)1.50954332
166Molar tooth sign on MRI (HP:0002419)1.49854767
167Abnormality of midbrain morphology (HP:0002418)1.49854767
168Hyponatremia (HP:0002902)1.48596822
169Postaxial foot polydactyly (HP:0001830)1.47341591
170Abnormality of the middle phalanges of the toes (HP:0010183)1.46510097
171Nephronophthisis (HP:0000090)1.46003784
172Ectropion (HP:0000656)1.43054589
173Bifid scrotum (HP:0000048)1.40777844
174Absent frontal sinuses (HP:0002688)1.40715069
175Hypoplastic female external genitalia (HP:0012815)1.38095070
176Abnormality of sodium homeostasis (HP:0010931)1.36982053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.93024840
2AKT36.46561100
3MST44.92019604
4FRK4.66246549
5ERN13.71676809
6TAOK33.57510138
7EEF2K3.37498659
8EPHA23.28493400
9MST1R3.08407898
10LATS12.96827626
11STK242.69247758
12SMG12.57032762
13MYLK2.48459254
14PBK2.30617253
15MAP3K22.19022816
16MAPKAPK32.11552749
17MAP3K122.06249608
18SCYL22.00962049
19BCKDK1.93731789
20SIK11.75111040
21PDK21.71226799
22LMTK21.68655244
23MAP2K21.62812005
24PTK61.61472033
25RPS6KB21.59884964
26TESK11.59089534
27MET1.57801515
28PIK3CA1.55125820
29BCR1.43028782
30CSK1.40025330
31LRRK21.38449739
32FER1.37805668
33ERBB31.35019838
34MAP3K61.33765874
35TTN1.29654943
36NME11.28057916
37TRIB31.27926878
38TTK1.21975111
39PIK3CG1.09816512
40STK101.07741862
41MAP3K31.02586883
42DMPK0.99680166
43PRKCI0.95127678
44TESK20.95052075
45NUAK10.94963054
46MARK20.93841717
47GRK60.93569358
48KSR20.93358046
49PKN20.93023950
50PDGFRA0.86448991
51TGFBR10.86096506
52EPHB20.85720562
53FGFR30.84329551
54RIPK10.82480307
55TAOK10.82374205
56PAK20.80085408
57DDR20.76254209
58STK390.75086313
59PTK20.73565219
60CDK120.73308691
61TRPM70.70006376
62ARAF0.69994964
63JAK30.69290335
64STK30.67509056
65EPHB10.66026967
66EPHA30.65416492
67MAP2K10.65253014
68TBK10.63036510
69LATS20.59281783
70TNK20.57919192
71LIMK10.57721724
72ROCK20.55390728
73MAP3K80.54901067
74TYK20.53800041
75PRKCD0.53028921
76ICK0.52497866
77BMX0.52235913
78MAP3K70.50496444
79JAK20.49272239
80ROCK10.45071723
81PDK40.44931168
82PDK30.44931168
83RPS6KA20.44082330
84ILK0.43755500
85PDPK10.41995203
86PRKAA20.39973177
87STK380.39106287
88CDK90.38557305
89EPHA40.38281956
90CSF1R0.37926806
91STK160.37673141
92FGFR10.37536397
93IRAK10.37213896
94JAK10.35900780
95BMPR20.35830696
96BRSK20.35763588
97PNCK0.34744447
98PDK10.32352582
99DYRK1B0.30698661
100NEK60.30073418
101PAK30.30001622
102CDK60.29654023
103PAK10.28903152
104MAP2K30.27869765
105PHKG20.27819358
106PHKG10.27819358
107SGK10.27750745
108NTRK10.27719598
109CHUK0.27603998
110RET0.27192639
111MELK0.27023573
112MTOR0.26882732
113ERBB20.26831997
114BRD40.26781395
115DAPK30.26295998
116MAP3K130.26009364
117FYN0.25247829
118AKT20.25113568
119PAK40.25086013
120CDC42BPA0.25061347
121FGFR20.24951845
122MAPKAPK50.24445460
123SGK2230.22312798
124SGK4940.22312798
125FGFR40.21889441
126PRKG20.21459531
127PDGFRB0.21113715
128MATK0.20942270
129WNK40.20429449
130OXSR10.19761322
131RPS6KB10.19759564
132PRKAA10.19530243
133MAP3K90.19249374
134RPS6KA10.18956324
135CAMK2G0.18854129
136PTK2B0.18691853
137STK38L0.18284168
138PIM20.17092374
139ERBB40.16526110
140CAMK2D0.15809620
141ADRBK10.15689293
142NLK0.15268676
143MAP3K10.14696330
144EGFR0.14396492
145PRKD10.12946658
146AURKB0.12887999
147SRC0.12525098
148MAP2K60.12229359
149MAPKAPK20.11321991

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.70182269
2Phenylalanine metabolism_Homo sapiens_hsa003604.50283536
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.45755493
4Sulfur metabolism_Homo sapiens_hsa009204.41834888
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.33117135
6Chemical carcinogenesis_Homo sapiens_hsa052043.33715416
7Tyrosine metabolism_Homo sapiens_hsa003503.29061181
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.28731066
9Linoleic acid metabolism_Homo sapiens_hsa005913.24710667
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.24091306
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.94824595
12Retinol metabolism_Homo sapiens_hsa008302.70320773
13N-Glycan biosynthesis_Homo sapiens_hsa005102.37140837
14Arachidonic acid metabolism_Homo sapiens_hsa005902.07777188
15Protein export_Homo sapiens_hsa030602.05683781
16Glutathione metabolism_Homo sapiens_hsa004802.01658219
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.86021731
18Tight junction_Homo sapiens_hsa045301.77835971
19Vibrio cholerae infection_Homo sapiens_hsa051101.73250805
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.68305800
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65368770
22Other glycan degradation_Homo sapiens_hsa005111.62284392
23Fructose and mannose metabolism_Homo sapiens_hsa000511.60003072
24Bladder cancer_Homo sapiens_hsa052191.52529779
25Thyroid hormone synthesis_Homo sapiens_hsa049181.48194415
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.44099228
27Adherens junction_Homo sapiens_hsa045201.40389463
28Ether lipid metabolism_Homo sapiens_hsa005651.39891121
29Amoebiasis_Homo sapiens_hsa051461.39484946
30Mineral absorption_Homo sapiens_hsa049781.31505962
31Endometrial cancer_Homo sapiens_hsa052131.31479955
32ECM-receptor interaction_Homo sapiens_hsa045121.29250009
33Prostate cancer_Homo sapiens_hsa052151.28848858
34Huntingtons disease_Homo sapiens_hsa050161.25569655
35Renin-angiotensin system_Homo sapiens_hsa046141.22672266
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21624558
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.21393300
38Small cell lung cancer_Homo sapiens_hsa052221.19490046
39Arginine biosynthesis_Homo sapiens_hsa002201.19398588
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.19146920
41Focal adhesion_Homo sapiens_hsa045101.15891371
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14577374
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09981405
44Circadian rhythm_Homo sapiens_hsa047101.09953627
45Hepatitis C_Homo sapiens_hsa051601.07579521
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90835552
47Hippo signaling pathway_Homo sapiens_hsa043900.83342466
48Inositol phosphate metabolism_Homo sapiens_hsa005620.82610124
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80336775
50Basal cell carcinoma_Homo sapiens_hsa052170.80135490
51Protein digestion and absorption_Homo sapiens_hsa049740.78995681
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77965349
53ErbB signaling pathway_Homo sapiens_hsa040120.76932782
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76402803
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.75824968
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74932078
57p53 signaling pathway_Homo sapiens_hsa041150.74359090
58Peroxisome_Homo sapiens_hsa041460.72701220
59Propanoate metabolism_Homo sapiens_hsa006400.72595628
60Pancreatic secretion_Homo sapiens_hsa049720.71872435
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71740865
62Arginine and proline metabolism_Homo sapiens_hsa003300.69793389
63mTOR signaling pathway_Homo sapiens_hsa041500.68445786
64Lysosome_Homo sapiens_hsa041420.68378020
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67516696
66Toxoplasmosis_Homo sapiens_hsa051450.66269846
67Proteoglycans in cancer_Homo sapiens_hsa052050.64459624
68Ovarian steroidogenesis_Homo sapiens_hsa049130.64340102
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61741468
70Hedgehog signaling pathway_Homo sapiens_hsa043400.61734082
71Insulin resistance_Homo sapiens_hsa049310.61448889
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60692439
73Non-small cell lung cancer_Homo sapiens_hsa052230.60627254
74Thyroid cancer_Homo sapiens_hsa052160.60596344
75Starch and sucrose metabolism_Homo sapiens_hsa005000.60145054
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59196039
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58575446
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57513769
79Choline metabolism in cancer_Homo sapiens_hsa052310.56877370
80Pancreatic cancer_Homo sapiens_hsa052120.56192670
81TGF-beta signaling pathway_Homo sapiens_hsa043500.55552478
82Salivary secretion_Homo sapiens_hsa049700.55067838
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54403897
84Glioma_Homo sapiens_hsa052140.52055772
85Chronic myeloid leukemia_Homo sapiens_hsa052200.51692497
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51261000
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50560499
88Collecting duct acid secretion_Homo sapiens_hsa049660.50552976
89Melanoma_Homo sapiens_hsa052180.49344767
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48940486
91Estrogen signaling pathway_Homo sapiens_hsa049150.48624996
92Gastric acid secretion_Homo sapiens_hsa049710.48473190
93Acute myeloid leukemia_Homo sapiens_hsa052210.47150151
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46489603
95Pathways in cancer_Homo sapiens_hsa052000.45444805
96PPAR signaling pathway_Homo sapiens_hsa033200.44826791
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44272181
98Steroid biosynthesis_Homo sapiens_hsa001000.44097569
99HIF-1 signaling pathway_Homo sapiens_hsa040660.43873932
100Fatty acid degradation_Homo sapiens_hsa000710.43615740
101AMPK signaling pathway_Homo sapiens_hsa041520.43437906
102Influenza A_Homo sapiens_hsa051640.42709910
103Gap junction_Homo sapiens_hsa045400.42554944
104Bile secretion_Homo sapiens_hsa049760.42390191
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42344548
106Prolactin signaling pathway_Homo sapiens_hsa049170.42313458
107Salmonella infection_Homo sapiens_hsa051320.42195102
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.41652210
109Endocytosis_Homo sapiens_hsa041440.41047864
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40401895
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.40069694
112Notch signaling pathway_Homo sapiens_hsa043300.39946636
113Sulfur relay system_Homo sapiens_hsa041220.39802302
114Caffeine metabolism_Homo sapiens_hsa002320.39486062
115VEGF signaling pathway_Homo sapiens_hsa043700.38832743
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.38191102
117GnRH signaling pathway_Homo sapiens_hsa049120.36931277
118Sphingolipid metabolism_Homo sapiens_hsa006000.36741312
119Serotonergic synapse_Homo sapiens_hsa047260.36427684
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35545303
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34261260
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33835042
123Histidine metabolism_Homo sapiens_hsa003400.33123271
124Phototransduction_Homo sapiens_hsa047440.32804183
125Folate biosynthesis_Homo sapiens_hsa007900.32502851
126ABC transporters_Homo sapiens_hsa020100.32412839
127Nitrogen metabolism_Homo sapiens_hsa009100.31742859
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.31718325
129Vitamin digestion and absorption_Homo sapiens_hsa049770.30939400
130Fatty acid elongation_Homo sapiens_hsa000620.30754707
131Wnt signaling pathway_Homo sapiens_hsa043100.30643141
132Platelet activation_Homo sapiens_hsa046110.30513325
133Metabolic pathways_Homo sapiens_hsa011000.30501975
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30334693
135Galactose metabolism_Homo sapiens_hsa000520.30041987
136beta-Alanine metabolism_Homo sapiens_hsa004100.29997508
137Tryptophan metabolism_Homo sapiens_hsa003800.29747224
138Ras signaling pathway_Homo sapiens_hsa040140.29231590
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28327709
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27677239
141Axon guidance_Homo sapiens_hsa043600.26496741
142Melanogenesis_Homo sapiens_hsa049160.24069425
143Fatty acid biosynthesis_Homo sapiens_hsa000610.20294877
144Apoptosis_Homo sapiens_hsa042100.18159468
145Complement and coagulation cascades_Homo sapiens_hsa046100.17448588
146Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.17167988
147Glycerolipid metabolism_Homo sapiens_hsa005610.14877174
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.14249480
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11039499

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